当前期刊: Nature Go to current issue    加入关注   
显示样式:        排序: IF: - GO 导出
我的关注
我的收藏
您暂时未登录!
登录
  • Structures of fungal and plant acetohydroxyacid synthases
    Nature (IF 42.778) Pub Date : 2020-07-08
    Thierry Lonhienne; Yu Shang Low; Mario D. Garcia; Tristan Croll; Yan Gao; Quan Wang; Lou Brillault; Craig M. Williams; James A. Fraser; Ross P. McGeary; Nicholas P. West; Michael J. Landsberg; Zihe Rao; Gerhard Schenk; Luke W. Guddat

    Acetohydroxyacid synthase (AHAS), also known as acetolactate synthase, is a FAD and ThDP-Mg2+-dependent enzyme that catalyses the first step in the biosynthesis of the branched chain amino acids (BCAAs)1. It is the target for over 50 commercial herbicides2. AHAS requires both catalytic and regulatory subunits for maximal activity and functionality. Herein, our structures of the hexadecameric Saccharomyces

    更新日期:2020-07-08
  • OpenSAFELY: factors associated with COVID-19 death in 17 million patients
    Nature (IF 42.778) Pub Date : 2020-07-08
    Elizabeth J. Williamson; Alex J. Walker; Krishnan Bhaskaran; Seb Bacon; Chris Bates; Caroline E. Morton; Helen J. Curtis; Amir Mehrkar; David Evans; Peter Inglesby; Jonathan Cockburn; Helen I. McDonald; Brian MacKenna; Laurie Tomlinson; Ian J. Douglas; Christopher T. Rentsch; Rohini Mathur; Angel Y. S. Wong; Richard Grieve; David Harrison; Harriet Forbes; Anna Schultze; Richard Croker; John Parry;

    COVID-19 has rapidly affected mortality worldwide1. There is unprecedented urgency to understand who is most at risk of severe outcomes, requiring new approaches for timely analysis of large datasets. Working on behalf of NHS England, here we created OpenSAFELY: a secure health analytics platform covering 40% of all patients in England, holding patient data within the existing data centre of a major

    更新日期:2020-07-08
  • Massive haplotypes underlie ecotypic differentiation in sunflowers
    Nature (IF 42.778) Pub Date : 2020-07-08
    Marco Todesco; Gregory L. Owens; Natalia Bercovich; Jean-Sébastien Légaré; Shaghayegh Soudi; Dylan O. Burge; Kaichi Huang; Katherine L. Ostevik; Emily B. M. Drummond; Ivana Imerovski; Kathryn Lande; Mariana A. Pascual-Robles; Mihir Nanavati; Mojtaba Jahani; Winnie Cheung; S. Evan Staton; Stéphane Muños; Rasmus Nielsen; Lisa A. Donovan; John M. Burke; Sam Yeaman; Loren H. Rieseberg

    Species often include multiple ecotypes that are adapted to different environments1. However, it is unclear how ecotypes arise and how their distinctive combinations of adaptive alleles are maintained despite hybridization with non-adapted populations2,3,4. Here, by resequencing 1,506 wild sunflowers from 3 species (Helianthus annuus, Helianthus petiolaris and Helianthus argophyllus), we identify 37 large

    更新日期:2020-07-08
  • Extracellular proteostasis prevents aggregation during pathogenic attack
    Nature (IF 42.778) Pub Date : 2020-07-08
    Ivan Gallotta; Aneet Sandhu; Maximilian Peters; Martin Haslbeck; Raimund Jung; Sinem Agilkaya; Jane L. Blersch; Christian Rödelsperger; Waltraud Röseler; Chaolie Huang; Ralf J. Sommer; Della C. David

    In metazoans, the secreted proteome participates in intercellular signalling and innate immunity, and builds the extracellular matrix scaffold around cells. Compared with the relatively constant intracellular environment, conditions for proteins in the extracellular space are harsher, and low concentrations of ATP prevent the activity of intracellular components of the protein quality-control machinery

    更新日期:2020-07-08
  • Tunable spin-polarized correlated states in twisted double bilayer graphene
    Nature (IF 42.778) Pub Date : 2020-07-08
    Xiaomeng Liu; Zeyu Hao; Eslam Khalaf; Jong Yeon Lee; Yuval Ronen; Hyobin Yoo; Danial Haei Najafabadi; Kenji Watanabe; Takashi Taniguchi; Ashvin Vishwanath; Philip Kim

    Reducing the energy bandwidth of electrons in a lattice below the long-range Coulomb interaction energy promotes correlation effects. Moiré superlattices—which are created by stacking van der Waals heterostructures with a controlled twist angle1,2,3—enable the engineering of electron band structure. Exotic quantum phases can emerge in an engineered moiré flat band. The recent discovery of correlated

    更新日期:2020-07-08
  • Coherent control of a surface structural phase transition
    Nature (IF 42.778) Pub Date : 2020-07-08
    Jan Gerrit Horstmann; Hannes Böckmann; Bareld Wit; Felix Kurtz; Gero Storeck; Claus Ropers

    Active optical control over matter is desirable in many scientific disciplines, with prominent examples in all-optical magnetic switching1,2, light-induced metastable or exotic phases of solids3,4,5,6,7,8 and the coherent control of chemical reactions9,10. Typically, these approaches dynamically steer a system towards states or reaction products far from equilibrium. In solids, metal-to-insulator transitions

    更新日期:2020-07-08
  • A bacterial cytidine deaminase toxin enables CRISPR-free mitochondrial base editing
    Nature (IF 42.778) Pub Date : 2020-07-08
    Beverly Y. Mok; Marcos H. de Moraes; Jun Zeng; Dustin E. Bosch; Anna V. Kotrys; Aditya Raguram; FoSheng Hsu; Matthew C. Radey; S. Brook Peterson; Vamsi K. Mootha; Joseph D. Mougous; David R. Liu

    Bacterial toxins represent a vast reservoir of biochemical diversity that can be repurposed for biomedical applications. Such proteins include a group of predicted interbacterial toxins of the deaminase superfamily, members of which have found application in gene-editing techniques1,2. Because previously described cytidine deaminases operate on single-stranded nucleic acids3, their use in base editing

    更新日期:2020-07-08
  • Sodium regulates clock time and output via an excitatory GABAergic pathway
    Nature (IF 42.778) Pub Date : 2020-07-08
    Claire Gizowski; Charles W. Bourque

    The suprachiasmatic nucleus (SCN) serves as the body’s master circadian clock that adaptively coordinates changes in physiology and behaviour in anticipation of changing requirements throughout the 24-h day–night cycle1,2,3,4. For example, the SCN opposes overnight adipsia by driving water intake before sleep5,6, and by driving the secretion of anti-diuretic hormone7,8 and lowering body temperature9

    更新日期:2020-07-08
  • Native American gene flow into Polynesia predating Easter Island settlement
    Nature (IF 42.778) Pub Date : 2020-07-08
    Alexander G. Ioannidis; Javier Blanco-Portillo; Karla Sandoval; Erika Hagelberg; Juan Francisco Miquel-Poblete; J. Víctor Moreno-Mayar; Juan Esteban Rodríguez-Rodríguez; Consuelo D. Quinto-Cortés; Kathryn Auckland; Tom Parks; Kathryn Robson; Adrian V. S. Hill; María C. Avila-Arcos; Alexandra Sockell; Julian R. Homburger; Genevieve L. Wojcik; Kathleen C. Barnes; Luisa Herrera; Soledad Berríos; Mónica

    The possibility of voyaging contact between prehistoric Polynesian and Native American populations has long intrigued researchers. Proponents have pointed to the existence of New World crops, such as the sweet potato and bottle gourd, in the Polynesian archaeological record, but nowhere else outside the pre-Columbian Americas1,2,3,4,5,6, while critics have argued that these botanical dispersals need

    更新日期:2020-07-08
  • Mitochondrial ubiquinol oxidation is necessary for tumour growth
    Nature (IF 42.778) Pub Date : 2020-07-08
    Inmaculada Martínez-Reyes; Luzivette Robles Cardona; Hyewon Kong; Karthik Vasan; Gregory S. McElroy; Marie Werner; Hermon Kihshen; Colleen R. Reczek; Samuel E. Weinberg; Peng Gao; Elizabeth M. Steinert; Raul Piseaux; G. R. Scott Budinger; Navdeep S. Chandel

    The mitochondrial electron transport chain (ETC) is necessary for tumour growth1,2,3,4,5,6 and its inhibition has demonstrated anti-tumour efficacy in combination with targeted therapies7,8,9. Furthermore, human brain and lung tumours display robust glucose oxidation by mitochondria10,11. However, it is unclear why a functional ETC is necessary for tumour growth in vivo. ETC function is coupled to

    更新日期:2020-07-08
  • Fitness trade-offs incurred by ovary-to-gut steroid signalling in Drosophila
    Nature (IF 42.778) Pub Date : 2020-07-08
    Sara Mahmoud H. Ahmed; Julieta A. Maldera; Damir Krunic; Gabriela O. Paiva-Silva; Clothilde Pénalva; Aurelio A. Teleman; Bruce A. Edgar

    Sexual dimorphism arises from genetic differences between male and female cells, and from systemic hormonal differences1,2,3. How sex hormones affect non-reproductive organs is poorly understood, yet highly relevant to health given the sex-biased incidence of many diseases4. Here we report that steroid signalling in Drosophila from the ovaries to the gut promotes growth of the intestine specifically

    更新日期:2020-07-08
  • Asymmetric mass ratios for bright double neutron-star mergers
    Nature (IF 42.778) Pub Date : 2020-07-08
    R. D. Ferdman; P. C. C. Freire; B. B. P. Perera; N. Pol; F. Camilo; S. Chatterjee; J. M. Cordes; F. Crawford; J. W. T. Hessels; V. M. Kaspi; M. A. McLaughlin; E. Parent; I. H. Stairs; J. van Leeuwen

    The discovery of a radioactively powered kilonova associated with the binary neutron-star merger GW170817 remains the only confirmed electromagnetic counterpart to a gravitational-wave event1,2. Observations of the late-time electromagnetic emission, however, do not agree with the expectations from standard neutron-star merger models. Although the large measured ejecta mass3,4 could be explained by

    更新日期:2020-07-08
  • Large-scale integration of artificial atoms in hybrid photonic circuits
    Nature (IF 42.778) Pub Date : 2020-07-08
    Noel H. Wan; Tsung-Ju Lu; Kevin C. Chen; Michael P. Walsh; Matthew E. Trusheim; Lorenzo De Santis; Eric A. Bersin; Isaac B. Harris; Sara L. Mouradian; Ian R. Christen; Edward S. Bielejec; Dirk Englund

    A central challenge in developing quantum computers and long-range quantum networks is the distribution of entanglement across many individually controllable qubits1. Colour centres in diamond have emerged as leading solid-state ‘artificial atom’ qubits2,3 because they enable on-demand remote entanglement4, coherent control of over ten ancillae qubits with minute-long coherence times5 and memory-enhanced

    更新日期:2020-07-08
  • Irritant-evoked activation and calcium modulation of the TRPA1 receptor
    Nature (IF 42.778) Pub Date : 2020-07-08
    Jianhua Zhao; John V. Lin King; Candice E. Paulsen; Yifan Cheng; David Julius

    The transient receptor potential ion channel TRPA1 is expressed by primary afferent nerve fibres, in which it functions as a low-threshold sensor for structurally diverse electrophilic irritants, including small volatile environmental toxicants and endogenous algogenic lipids1. TRPA1 is also a ‘receptor-operated’ channel whose activation downstream of metabotropic receptors elicits inflammatory pain

    更新日期:2020-07-08
  • Envelope protein ubiquitination drives entry and pathogenesis of Zika virus
    Nature (IF 42.778) Pub Date : 2020-07-08
    Maria I. Giraldo; Hongjie Xia; Leopoldo Aguilera-Aguirre; Adam Hage; Sarah van Tol; Chao Shan; Xuping Xie; Gail L. Sturdevant; Shelly J. Robertson; Kristin L. McNally; Kimberly Meade-White; Sasha R. Azar; Shannan L. Rossi; Wendy Maury; Michael Woodson; Holly Ramage; Jeffrey R. Johnson; Nevan J. Krogan; Marc C. Morais; Sonja M. Best; Pei-Yong Shi; Ricardo Rajsbaum

    Zika virus (ZIKV) belongs to the family Flaviviridae, and is related to other viruses that cause human diseases. Unlike other flaviviruses, ZIKV infection can cause congenital neurological disorders and replicates efficiently in reproductive tissues1,2,3. Here we show that the envelope protein (E) of ZIKV is polyubiquitinated by the E3 ubiquitin ligase TRIM7 through Lys63 (K63)-linked polyubiquitination

    更新日期:2020-07-08
  • A mobile robotic chemist
    Nature (IF 42.778) Pub Date : 2020-07-08
    Benjamin Burger; Phillip M. Maffettone; Vladimir V. Gusev; Catherine M. Aitchison; Yang Bai; Xiaoyan Wang; Xiaobo Li; Ben M. Alston; Buyi Li; Rob Clowes; Nicola Rankin; Brandon Harris; Reiner Sebastian Sprick; Andrew I. Cooper

    Technologies such as batteries, biomaterials and heterogeneous catalysts have functions that are defined by mixtures of molecular and mesoscale components. As yet, this multi-length-scale complexity cannot be fully captured by atomistic simulations, and the design of such materials from first principles is still rare1,2,3,4,5. Likewise, experimental complexity scales exponentially with the number of

    更新日期:2020-07-08
  • Glucose metabolism links astroglial mitochondria to cannabinoid effects
    Nature (IF 42.778) Pub Date : 2020-07-08
    Daniel Jimenez-Blasco; Arnau Busquets-Garcia; Etienne Hebert-Chatelain; Roman Serrat; Carlos Vicente-Gutierrez; Christina Ioannidou; Paula Gómez-Sotres; Irene Lopez-Fabuel; Monica Resch-Beusher; Eva Resel; Dorian Arnouil; Dave Saraswat; Marjorie Varilh; Astrid Cannich; Francisca Julio-Kalajzic; Itziar Bonilla-Del Río; Angeles Almeida; Nagore Puente; Svein Achicallende; Maria-Luz Lopez-Rodriguez; Charlotte

    Astrocytes take up glucose from the bloodstream to provide energy to the brain, thereby allowing neuronal activity and behavioural responses1,2,3,4,5. By contrast, astrocytes are under neuronal control through specific neurotransmitter receptors5,6,7. However, whether the activation of astroglial receptors can directly regulate cellular glucose metabolism to eventually modulate behavioural responses

    更新日期:2020-07-08
  • Potential for large-scale CO 2 removal via enhanced rock weathering with croplands
    Nature (IF 42.778) Pub Date : 2020-07-08
    David J. Beerling; Euripides P. Kantzas; Mark R. Lomas; Peter Wade; Rafael M. Eufrasio; Phil Renforth; Binoy Sarkar; M. Grace Andrews; Rachael H. James; Christopher R. Pearce; Jean-Francois Mercure; Hector Pollitt; Philip B. Holden; Neil R. Edwards; Madhu Khanna; Lenny Koh; Shaun Quegan; Nick F. Pidgeon; Ivan A. Janssens; James Hansen; Steven A. Banwart

    Enhanced silicate rock weathering (ERW), deployable with croplands, has potential use for atmospheric carbon dioxide (CO2) removal (CDR), which is now necessary to mitigate anthropogenic climate change1. ERW also has possible co-benefits for improved food and soil security, and reduced ocean acidification2,3,4. Here we use an integrated performance modelling approach to make an initial techno-economic

    更新日期:2020-07-08
  • Microbiota modulate sympathetic neurons via a gut–brain circuit
    Nature (IF 42.778) Pub Date : 2020-07-08
    Paul A. Muller; Marc Schneeberger; Fanny Matheis; Putianqi Wang; Zachary Kerner; Anoj Ilanges; Kyle Pellegrino; Josefina del Mármol; Tiago B. R. Castro; Munehiro Furuichi; Matthew Perkins; Wenfei Han; Arka Rao; Amanda J. Picard; Justin R. Cross; Kenya Honda; Ivan de Araujo; Daniel Mucida

    Connections between the gut and brain monitor the intestinal tissue and its microbial and dietary content1, regulating both physiological intestinal functions such as nutrient absorption and motility2,3, and brain-wired feeding behaviour2. It is therefore plausible that circuits exist to detect gut microorganisms and relay this information to areas of the central nervous system that, in turn, regulate

    更新日期:2020-07-08
  • Untying the insulating and superconducting orders in magic-angle graphene
    Nature (IF 42.778) Pub Date : 2020-07-06
    Petr Stepanov; Ipsita Das; Xiaobo Lu; Ali Fahimniya; Kenji Watanabe; Takashi Taniguchi; Frank H. L. Koppens; Johannes Lischner; Leonid Levitov; Dmitri K. Efetov

    The coexistence of superconducting and correlated insulating states in magic-angle twisted bilayer graphene1,2,3,4,5,6,7,8,9,10,11 prompts fascinating questions about their relationship. Independent control of the microscopic mechanisms that govern these phases could help uncover their individual roles and shed light on their intricate interplay. Here we report on direct tuning of electronic interactions

    更新日期:2020-07-06
  • Structural basis of CXC chemokine receptor 2 activation and signalling
    Nature (IF 42.778) Pub Date : 2020-07-01
    Kaiwen Liu; Lijie Wu; Shuguang Yuan; Meng Wu; Yueming Xu; Qianqian Sun; Shu Li; Suwen Zhao; Tian Hua; Zhi-Jie Liu

    Chemokines and their receptors mediate cell migration, which influences multiple fundamental biological processes and disease conditions, such as inflammation and cancer1. Although ample efforts have been invested into the structural investigation of the chemokine receptors and receptor–chemokine recognition2–4, less is known about endogenous chemokine-induced receptor activation and G protein coupling

    更新日期:2020-07-01
  • Observation of branched flow of light
    Nature (IF 42.778) Pub Date : 2020-07-01
    Anatoly Patsyk; Uri Sivan; Mordechai Segev; Miguel A. Bandres

    When waves propagate through a weak disordered potential with correlation length larger than the wavelength, they form channels (branches) of enhanced intensity that keep dividing as the waves propagate1. This fundamental wave phenomenon is known as branched flow. It was first observed for electrons1,2,3,4,5,6 and for microwave cavities7,8, and it is generally expected for waves with vastly different

    更新日期:2020-07-01
  • Suppression of proteolipid protein rescues Pelizaeus-Merzbacher disease
    Nature (IF 42.778) Pub Date : 2020-07-01
    Matthew S. Elitt; Lilianne Barbar; H. Elizabeth Shick; Berit E. Powers; Yuka Maeno-Hikichi; Mayur Madhavan; Kevin C. Allan; Baraa S. Nawash; Artur S. Gevorgyan; Stevephen Hung; Zachary S. Nevin; Hannah E. Olsen; Midori Hitomi; Daniela M. Schlatzer; Hien T. Zhao; Adam Swayze; David F. LePage; Weihong Jiang; Ronald A. Conlon; Frank Rigo; Paul J. Tesar

    Mutations in proteolipid protein 1 (PLP1) result in failure of myelination and neurological dysfunction in the X-linked leukodystrophy Pelizaeus-Merzbacher disease (PMD)1,2. Most PLP1 mutations, including point mutations and supernumerary copy variants, lead to severe and fatal disease. PLP1-null patients and mice, however, can display comparatively mild phenotypes, suggesting that PLP1-suppression

    更新日期:2020-07-01
  • Chemical gradients in human enamel crystallites
    Nature (IF 42.778) Pub Date : 2020-07-01
    Karen A. DeRocher; Paul J. M. Smeets; Berit H. Goodge; Michael J. Zachman; Prasanna V. Balachandran; Linus Stegbauer; Michael J. Cohen; Lyle M. Gordon; James M. Rondinelli; Lena F. Kourkoutis; Derk Joester

    Dental enamel is a principal component of teeth1, and has evolved to bear large chewing forces, resist mechanical fatigue and withstand wear over decades2. Functional impairment and loss of dental enamel, caused by developmental defects or tooth decay (caries), affect health and quality of life, with associated costs to society3. Although the past decade has seen progress in our understanding of enamel

    更新日期:2020-07-01
  • Abrupt increase in harvested forest area over Europe after 2015
    Nature (IF 42.778) Pub Date : 2020-07-01
    Guido Ceccherini; Gregory Duveiller; Giacomo Grassi; Guido Lemoine; Valerio Avitabile; Roberto Pilli; Alessandro Cescatti

    Forests provide a series of ecosystem services that are crucial to our society. In the European Union (EU), forests account for approximately 38% of the total land surface1. These forests are important carbon sinks, and their conservation efforts are vital for the EU’s vision of achieving climate neutrality by 20502. However, the increasing demand for forest services and products, driven by the bioeconomy

    更新日期:2020-07-01
  • A remnant planetary core in the hot-Neptune desert
    Nature (IF 42.778) Pub Date : 2020-07-01
    David J. Armstrong; Théo A. Lopez; Vardan Adibekyan; Richard A. Booth; Edward M. Bryant; Karen A. Collins; Magali Deleuil; Alexandre Emsenhuber; Chelsea X. Huang; George W. King; Jorge Lillo-Box; Jack J. Lissauer; Elisabeth Matthews; Olivier Mousis; Louise D. Nielsen; Hugh Osborn; Jon Otegi; Nuno C. Santos; Sérgio G. Sousa; Keivan G. Stassun; Dimitri Veras; Carl Ziegler; Jack S. Acton; Jose M. Almenara;

    The interiors of giant planets remain poorly understood. Even for the planets in the Solar System, difficulties in observation lead to large uncertainties in the properties of planetary cores. Exoplanets that have undergone rare evolutionary processes provide a route to understanding planetary interiors. Planets found in and near the typically barren hot-Neptune ‘desert’1,2 (a region in mass–radius

    更新日期:2020-07-01
  • Structural cells are key regulators of organ-specific immune responses
    Nature (IF 42.778) Pub Date : 2020-07-01
    Thomas Krausgruber; Nikolaus Fortelny; Victoria Fife-Gernedl; Martin Senekowitsch; Linda C. Schuster; Alexander Lercher; Amelie Nemc; Christian Schmidl; André F. Rendeiro; Andreas Bergthaler; Christoph Bock

    The mammalian immune system implements a remarkably effective set of mechanisms for fighting pathogens1. Its main components are haematopoietic immune cells, including myeloid cells that control innate immunity, and lymphoid cells that constitute adaptive immunity2. However, immune functions are not unique to haematopoietic cells, and many other cell types display basic mechanisms of pathogen defence3

    更新日期:2020-07-01
  • Clinical targeting of HIV capsid protein with a long-acting small molecule
    Nature (IF 42.778) Pub Date : 2020-07-01
    John O. Link; Martin S. Rhee; Winston C. Tse; Jim Zheng; John R. Somoza; William Rowe; Rebecca Begley; Anna Chiu; Andrew Mulato; Derek Hansen; Eric Singer; Luong K. Tsai; Rujuta A. Bam; Chien-Hung Chou; Eda Canales; Gediminas Brizgys; Jennifer R. Zhang; Jiayao Li; Michael Graupe; Philip Morganelli; Qi Liu; Qiaoyin Wu; Randall L. Halcomb; Roland D. Saito; Scott D. Schroeder; Scott E. Lazerwith; Steven

    Oral antiretroviral agents provide life-saving treatments for millions of people living with HIV, and can prevent new infections via pre-exposure prophylaxis1,2,3,4,5. However, some people living with HIV who are heavily treatment-experienced have limited or no treatment options, owing to multidrug resistance6. In addition, suboptimal adherence to oral daily regimens can negatively affect the outcome

    更新日期:2020-07-01
  • Laser picoscopy of valence electrons in solids
    Nature (IF 42.778) Pub Date : 2020-07-01
    H. Lakhotia; H. Y. Kim; M. Zhan; S. Hu; S. Meng; E. Goulielmakis

    Valence electrons contribute a small fraction of the total electron density of materials, but they determine their essential chemical, electronic and optical properties. Strong laser fields can probe electrons in valence orbitals1,2,3 and their dynamics4,5,6 in the gas phase. Previous laser studies of solids have associated high-harmonic emission7,8,9,10,11,12 with the spatial arrangement of atoms

    更新日期:2020-07-01
  • Extensive signal integration by the phytohormone protein network
    Nature (IF 42.778) Pub Date : 2020-07-01
    Melina Altmann; Stefan Altmann; Patricia A. Rodriguez; Benjamin Weller; Lena Elorduy Vergara; Julius Palme; Nora Marín-de la Rosa; Mayra Sauer; Marion Wenig; José Antonio Villaécija-Aguilar; Jennifer Sales; Chung-Wen Lin; Ramakrishnan Pandiarajan; Veronika Young; Alexandra Strobel; Lisa Gross; Samy Carbonnel; Karl G. Kugler; Antoni Garcia-Molina; George W. Bassel; Claudia Falter; Klaus F. X. Mayer;

    Plant hormones coordinate responses to environmental cues with developmental programs1, and are fundamental for stress resilience and agronomic yield2. The core signalling pathways underlying the effects of phytohormones have been elucidated by genetic screens and hypothesis-driven approaches, and extended by interactome studies of select pathways3. However, fundamental questions remain about how information

    更新日期:2020-07-01
  • Systematic quantitative analysis of ribosome inventory during nutrient stress
    Nature (IF 42.778) Pub Date : 2020-07-01
    Heeseon An; Alban Ordureau; Maria Körner; Joao A. Paulo; J. Wade Harper

    Mammalian cells reorganize their proteomes in response to nutrient stress through translational suppression and degradative mechanisms using the proteasome and autophagy systems1,2. Ribosomes are central targets of this response, as they are responsible for translation and subject to lysosomal turnover during nutrient stress3,4,5. The abundance of ribosomal (r)-proteins (around 6% of the proteome;

    更新日期:2020-07-01
  • Physiological blood–brain transport is impaired with age by a shift in transcytosis
    Nature (IF 42.778) Pub Date : 2020-07-01
    Andrew C. Yang; Marc Y. Stevens; Michelle B. Chen; Davis P. Lee; Daniel Stähli; David Gate; Kévin Contrepois; Winnie Chen; Tal Iram; Lichao Zhang; Ryan T. Vest; Aisling Chaney; Benoit Lehallier; Niclas Olsson; Haley du Bois; Ryan Hsieh; Haley C. Cropper; Daniela Berdnik; Lulin Li; Elizabeth Y. Wang; Gavin M. Traber; Carolyn R. Bertozzi; Jian Luo; Michael P. Snyder; Joshua E. Elias; Stephen R. Quake;

    The vascular interface of the brain, known as the blood–brain barrier (BBB), is understood to maintain brain function in part via its low transcellular permeability1,2,3. Yet, recent studies have demonstrated that brain ageing is sensitive to circulatory proteins4,5. Thus, it is unclear whether permeability to individually injected exogenous tracers—as is standard in BBB studies—fully represents blood-to-brain

    更新日期:2020-07-01
  • A substrate-specific mTORC1 pathway underlies Birt–Hogg–Dubé syndrome
    Nature (IF 42.778) Pub Date : 2020-07-01
    Gennaro Napolitano; Chiara Di Malta; Alessandra Esposito; Mariana E. G. de Araujo; Salvatore Pece; Giovanni Bertalot; Maria Matarese; Valerio Benedetti; Angela Zampelli; Taras Stasyk; Diletta Siciliano; Alessandro Venuta; Marcella Cesana; Claudia Vilardo; Edoardo Nusco; Jlenia Monfregola; Alessia Calcagnì; Pier Paolo Di Fiore; Lukas A. Huber; Andrea Ballabio

    The mechanistic target of rapamycin complex 1 (mTORC1) is a key metabolic hub that controls the cellular response to environmental cues by exerting its kinase activity on multiple substrates1,2,3. However, whether mTORC1 responds to diverse stimuli by differentially phosphorylating specific substrates is poorly understood. Here we show that transcription factor EB (TFEB), a master regulator of lysosomal

    更新日期:2020-07-01
  • Structure and flexibility in cortical representations of odour space
    Nature (IF 42.778) Pub Date : 2020-07-01
    Stan L. Pashkovski; Giuliano Iurilli; David Brann; Daniel Chicharro; Kristen Drummey; Kevin Franks; Stefano Panzeri; Sandeep Robert Datta

    The cortex organizes sensory information to enable discrimination and generalization1,2,3,4. As systematic representations of chemical odour space have not yet been described in the olfactory cortex, it remains unclear how odour relationships are encoded to place chemically distinct but similar odours, such as lemon and orange, into perceptual categories, such as citrus5,6,7. Here, by combining chemoinformatics

    更新日期:2020-07-01
  • Quantum correlations between light and the kilogram-mass mirrors of LIGO
    Nature (IF 42.778) Pub Date : 2020-07-01
    Haocun Yu; L. McCuller; M. Tse; N. Kijbunchoo; L. Barsotti; N. Mavalvala

    The measurement of minuscule forces and displacements with ever greater precision is inhibited by the Heisenberg uncertainty principle, which imposes a limit to the precision with which the position of an object can be measured continuously, known as the standard quantum limit1,2,3,4. When light is used as the probe, the standard quantum limit arises from the balance between the uncertainties of the

    更新日期:2020-07-01
  • Cryo-EM of elongating ribosome with EF-Tu•GTP elucidates tRNA proofreading
    Nature (IF 42.778) Pub Date : 2020-07-01
    Anna B. Loveland; Gabriel Demo; Andrei A. Korostelev

    Ribosomes accurately decode mRNA by proofreading each aminoacyl-tRNA that is delivered by the elongation factor EF-Tu1. To understand the molecular mechanism of this proofreading step it is necessary to visualize GTP-catalysed elongation, which has remained a challenge2,3,4. Here we use time-resolved cryogenic electron microscopy to reveal 33 ribosomal states after the delivery of aminoacyl-tRNA by

    更新日期:2020-07-01
  • Wapl repression by Pax5 promotes V gene recombination by Igh loop extrusion
    Nature (IF 42.778) Pub Date : 2020-07-01
    Louisa Hill; Anja Ebert; Markus Jaritz; Gordana Wutz; Kota Nagasaka; Hiromi Tagoh; Daniela Kostanova-Poliakova; Karina Schindler; Qiong Sun; Peter Bönelt; Maria Fischer; Jan-Michael Peters; Meinrad Busslinger

    Nuclear processes, such as V(D)J recombination, are orchestrated by the three-dimensional organization of chromosomes at multiple levels, including compartments1 and topologically associated domains (TADs)2,3 consisting of chromatin loops4. TADs are formed by chromatin-loop extrusion5,6,7, which depends on the loop-extrusion function of the ring-shaped cohesin complex8,9,10,11,12. Conversely, the cohesin-release

    更新日期:2020-07-01
  • Suppression of a SARS-CoV-2 outbreak in the Italian municipality of Vo’
    Nature (IF 42.778) Pub Date : 2020-06-30
    Enrico Lavezzo; Elisa Franchin; Constanze Ciavarella; Gina Cuomo-Dannenburg; Luisa Barzon; Claudia Del Vecchio; Lucia Rossi; Riccardo Manganelli; Arianna Loregian; Nicolò Navarin; Davide Abate; Manuela Sciro; Stefano Merigliano; Ettore De Canale; Maria Cristina Vanuzzo; Valeria Besutti; Francesca Saluzzo; Francesco Onelia; Monia Pacenti; Saverio Parisi; Giovanni Carretta; Daniele Donato; Luciano Flor;

    On the 21st of February 2020 a resident of the municipality of Vo’, a small town near Padua, died of pneumonia due to SARS-CoV-2 infection1. This was the first COVID-19 death detected in Italy since the emergence of SARS-CoV-2 in the Chinese city of Wuhan, Hubei province2. In response, the regional authorities imposed the lockdown of the whole municipality for 14 days3. We collected information on

    更新日期:2020-06-30
  • Structures of metabotropic GABA B receptor
    Nature (IF 42.778) Pub Date : 2020-06-24
    Makaía M. Papasergi-Scott; Michael J. Robertson; Alpay B. Seven; Ouliana Panova; Jesper M. Mathiesen; Georgios Skiniotis

    GABA (γ-aminobutyric acid) stimulation of the metabotropic GABAB receptor results in prolonged inhibition of neurotransmission that is central to brain physiology1. GABAB belongs to the Family C of G protein-coupled receptors (GPCRs), which operate as dimers to relay synaptic neurotransmitter signals into a cellular response through the binding and activation of heterotrimeric G proteins2,3. GABAB

    更新日期:2020-06-24
  • Structure of human GABA B receptor in an inactive state
    Nature (IF 42.778) Pub Date : 2020-06-24
    Jinseo Park; Ziao Fu; Aurel Frangaj; Jonathan Liu; Lidia Mosyak; Tong Shen; Vesna N. Slavkovich; Kimberly M. Ray; Jaume Taura; Baohua Cao; Yong Geng; Hao Zuo; Yongjun Kou; Robert Grassucci; Shaoxia Chen; Zheng Liu; Xin Lin; Justin P. Williams; William J. Rice; Edward T. Eng; Rick K. Huang; Rajesh K. Soni; Brian Kloss; Zhiheng Yu; Jonathan A. Javitch; Wayne A. Hendrickson; Paul A. Slesinger; Matthias

    The human GABAB receptor—a member of the class C family of G-protein-coupled receptors (GPCRs)—mediates inhibitory neurotransmission and has been implicated in epilepsy, pain and addiction1. A unique GPCR that is known to require heterodimerization for function2,3,4,5,6, the GABAB receptor has two subunits, GABAB1 and GABAB2, that are structurally homologous but perform distinct and complementary functions

    更新日期:2020-06-24
  • Mapping the emergence of molecular vibrations mediating bond formation
    Nature (IF 42.778) Pub Date : 2020-06-24
    Jong Goo Kim; Shunsuke Nozawa; Hanui Kim; Eun Hyuk Choi; Tokushi Sato; Tae Wu Kim; Kyung Hwan Kim; Hosung Ki; Jungmin Kim; Minseo Choi; Yunbeom Lee; Jun Heo; Key Young Oang; Kouhei Ichiyanagi; Ryo Fukaya; Jae Hyuk Lee; Jaeku Park; Intae Eom; Sae Hwan Chun; Sunam Kim; Minseok Kim; Tetsuo Katayama; Tadashi Togashi; Sigeki Owada; Makina Yabashi; Sang Jin Lee; Seonggon Lee; Chi Woo Ahn; Doo-Sik Ahn; Jiwon

    Fundamental studies of chemical reactions often consider the molecular dynamics along a reaction coordinate using a calculated or suggested potential energy surface1,2,3,4,5. But fully mapping such dynamics experimentally, by following all nuclear motions in a time-resolved manner—that is, the motions of wavepackets—is challenging and has not yet been realized even for the simple stereotypical bimolecular

    更新日期:2020-06-24
  • FLT3 stop mutation increases FLT3 ligand level and risk of autoimmune thyroid disease
    Nature (IF 42.778) Pub Date : 2020-06-24
    Saedis Saevarsdottir; Thorunn A. Olafsdottir; Erna V. Ivarsdottir; Gisli H. Halldorsson; Kristbjorg Gunnarsdottir; Asgeir Sigurdsson; Ari Johannesson; Jon K. Sigurdsson; Thorhildur Juliusdottir; Sigrun H. Lund; Asgeir O. Arnthorsson; Edda L. Styrmisdottir; Julius Gudmundsson; Gerdur M. Grondal; Kristjan Steinsson; Lars Alfredsson; Johan Askling; Rafn Benediktsson; Ragnar Bjarnason; Arni J. Geirsson;

    Autoimmune thyroid disease is the most common autoimmune disease and is highly heritable1. Here, by using a genome-wide association study of 30,234 cases and 725,172 controls from Iceland and the UK Biobank, we find 99 sequence variants at 93 loci, of which 84 variants are previously unreported2,3,4,5,6,7. A low-frequency (1.36%) intronic variant in FLT3 (rs76428106-C) has the largest effect on risk

    更新日期:2020-06-24
  • Reversing a model of Parkinson’s disease with in situ converted nigral neurons
    Nature (IF 42.778) Pub Date : 2020-06-24
    Hao Qian; Xinjiang Kang; Jing Hu; Dongyang Zhang; Zhengyu Liang; Fan Meng; Xuan Zhang; Yuanchao Xue; Roy Maimon; Steven F. Dowdy; Neal K. Devaraj; Zhuan Zhou; William C. Mobley; Don W. Cleveland; Xiang-Dong Fu

    Parkinson’s disease is characterized by loss of dopamine neurons in the substantia nigra1. Similar to other major neurodegenerative disorders, there are no disease-modifying treatments for Parkinson’s disease. While most treatment strategies aim to prevent neuronal loss or protect vulnerable neuronal circuits, a potential alternative is to replace lost neurons to reconstruct disrupted circuits2. Here

    更新日期:2020-06-24
  • Whole-genome sequencing of patients with rare diseases in a national health system
    Nature (IF 42.778) Pub Date : 2020-06-24
    Ernest Turro; William J. Astle; Karyn Megy; Stefan Gräf; Daniel Greene; Olga Shamardina; Hana Lango Allen; Alba Sanchis-Juan; Mattia Frontini; Chantal Thys; Jonathan Stephens; Rutendo Mapeta; Oliver S. Burren; Kate Downes; Matthias Haimel; Salih Tuna; Sri V. V. Deevi; Timothy J. Aitman; David L. Bennett; Paul Calleja; Keren Carss; Mark J. Caulfield; Patrick F. Chinnery; Peter H. Dixon; Daniel P. Gale;

    Most patients with rare diseases do not receive a molecular diagnosis and the aetiological variants and causative genes for more than half such disorders remain to be discovered1. Here we used whole-genome sequencing (WGS) in a national health system to streamline diagnosis and to discover unknown aetiological variants in the coding and non-coding regions of the genome. We generated WGS data for 13

    更新日期:2020-06-24
  • IL-18BP is a secreted immune checkpoint and barrier to IL-18 immunotherapy
    Nature (IF 42.778) Pub Date : 2020-06-24
    Ting Zhou; William Damsky; Orr-El Weizman; Meaghan K. McGeary; K. Patricia Hartmann; Connor E. Rosen; Suzanne Fischer; Ruaidhri Jackson; Richard A. Flavell; Jun Wang; Miguel F. Sanmamed; Marcus W. Bosenberg; Aaron M. Ring

    Cytokines were the first modern immunotherapies to produce durable responses in patients with advanced cancer, but they have only modest efficacy and limited tolerability1,2. In an effort to identify alternative cytokine pathways for immunotherapy, we found that components of the interleukin-18 (IL-18) pathway are upregulated on tumour-infiltrating lymphocytes, suggesting that IL-18 therapy could enhance

    更新日期:2020-06-24
  • DNA surface exploration and operator bypassing during target search
    Nature (IF 42.778) Pub Date : 2020-06-24
    Emil Marklund; Brad van Oosten; Guanzhong Mao; Elias Amselem; Kalle Kipper; Anton Sabantsev; Andrew Emmerich; Daniel Globisch; Xuan Zheng; Laura C. Lehmann; Otto G. Berg; Magnus Johansson; Johan Elf; Sebastian Deindl

    Many proteins that bind specific DNA sequences search the genome by combining three-dimensional diffusion with one-dimensional sliding on nonspecific DNA1,2,3,4,5. Here we combine resonance energy transfer and fluorescence correlation measurements to characterize how individual lac repressor (LacI) molecules explore the DNA surface during the one-dimensional phase of target search. To track the rotation

    更新日期:2020-06-24
  • Single-molecule imaging of transcription dynamics in somatic stem cells
    Nature (IF 42.778) Pub Date : 2020-06-24
    Justin C. Wheat; Yehonatan Sella; Michael Willcockson; Arthur I. Skoultchi; Aviv Bergman; Robert H. Singer; Ulrich Steidl

    Molecular noise is a natural phenomenon that is inherent to all biological systems1,2. How stochastic processes give rise to the robust outcomes that support tissue homeostasis remains unclear. Here we use single-molecule RNA fluorescent in situ hybridization (smFISH) on mouse stem cells derived from haematopoietic tissue to measure the transcription dynamics of three key genes that encode transcription

    更新日期:2020-06-24
  • High-strength Damascus steel by additive manufacturing
    Nature (IF 42.778) Pub Date : 2020-06-24
    Philipp Kürnsteiner; Markus Benjamin Wilms; Andreas Weisheit; Baptiste Gault; Eric Aimé Jägle; Dierk Raabe

    Laser additive manufacturing is attractive for the production of complex, three-dimensional parts from metallic powder using a computer-aided design model1,2,3. The approach enables the digital control of the processing parameters and thus the resulting alloy’s microstructure, for example, by using high cooling rates and cyclic re-heating4,5,6,7,8,9,10. We recently showed that this cyclic re-heating

    更新日期:2020-06-24
  • A planet within the debris disk around the pre-main-sequence star AU Microscopii
    Nature (IF 42.778) Pub Date : 2020-06-24
    Peter Plavchan; Thomas Barclay; Jonathan Gagné; Peter Gao; Bryson Cale; William Matzko; Diana Dragomir; Sam Quinn; Dax Feliz; Keivan Stassun; Ian J. M. Crossfield; David A. Berardo; David W. Latham; Ben Tieu; Guillem Anglada-Escudé; George Ricker; Roland Vanderspek; Sara Seager; Joshua N. Winn; Jon M. Jenkins; Stephen Rinehart; Akshata Krishnamurthy; Scott Dynes; John Doty; Fred Adams; Dennis A. Afanasev;

    AU Microscopii (AU Mic) is the second closest pre-main-sequence star, at a distance of 9.79 parsecs and with an age of 22 million years1. AU Mic possesses a relatively rare2 and spatially resolved3 edge-on debris disk extending from about 35 to 210 astronomical units from the star4, and with clumps exhibiting non-Keplerian motion5,6,7. Detection of newly formed planets around such a star is challenged

    更新日期:2020-06-24
  • Intracellular pH controls WNT downstream of glycolysis in amniote embryos
    Nature (IF 42.778) Pub Date : 2020-06-24
    Masayuki Oginuma; Yukiko Harima; Oscar A. Tarazona; Margarete Diaz-Cuadros; Arthur Michaut; Tohru Ishitani; Fengzhu Xiong; Olivier Pourquié

    Formation of the body of vertebrate embryos proceeds sequentially by posterior addition of tissues from the tail bud. Cells of the tail bud and the posterior presomitic mesoderm, which control posterior elongation1, exhibit a high level of aerobic glycolysis that is reminiscent of the metabolic status of cancer cells experiencing the Warburg effect2,3. Glycolytic activity downstream of fibroblast growth

    更新日期:2020-06-24
  • Pervasive lesion segregation shapes cancer genome evolution
    Nature (IF 42.778) Pub Date : 2020-06-24
    Sarah J. Aitken; Craig J. Anderson; Frances Connor; Oriol Pich; Vasavi Sundaram; Christine Feig; Tim F. Rayner; Margus Lukk; Stuart Aitken; Juliet Luft; Elissavet Kentepozidou; Claudia Arnedo-Pac; Sjoerd V. Beentjes; Susan E. Davies; Ruben M. Drews; Ailith Ewing; Vera B. Kaiser; Ava Khamseh; Erika López-Arribillaga; Aisling M. Redmond; Javier Santoyo-Lopez; Inés Sentís; Lana Talmane; Andrew D. Yates;

    Cancers arise through the acquisition of oncogenic mutations and grow by clonal expansion1,2. Here we reveal that most mutagenic DNA lesions are not resolved into a mutated DNA base pair within a single cell cycle. Instead, DNA lesions segregate, unrepaired, into daughter cells for multiple cell generations, resulting in the chromosome-scale phasing of subsequent mutations. We characterize this process

    更新日期:2020-06-24
  • Optical Fourier surfaces
    Nature (IF 42.778) Pub Date : 2020-06-24
    Nolan Lassaline; Raphael Brechbühler; Sander J. W. Vonk; Korneel Ridderbeek; Martin Spieser; Samuel Bisig; Boris le Feber; Freddy T. Rabouw; David J. Norris

    Gratings1 and holograms2 use patterned surfaces to tailor optical signals by diffraction. Despite their long history, variants with remarkable functionalities continue to be developed3,4. Further advances could exploit Fourier optics5, which specifies the surface pattern that generates a desired diffracted output through its Fourier transform. To shape the optical wavefront, the ideal surface profile

    更新日期:2020-06-24
  • Monogenic and polygenic inheritance become instruments for clonal selection
    Nature (IF 42.778) Pub Date : 2020-06-24
    Po-Ru Loh; Giulio Genovese; Steven A. McCarroll

    Clonally expanded blood cells that contain somatic mutations (clonal haematopoiesis) are commonly acquired with age and increase the risk of blood cancer1,2,3,4,5,6,7,8,9. The blood clones identified so far contain diverse large-scale mosaic chromosomal alterations (deletions, duplications and copy-neutral loss of heterozygosity (CN-LOH)) on all chromosomes1,2,5,6,9, but the sources of selective advantage

    更新日期:2020-06-24
  • Variable water input controls evolution of the Lesser Antilles volcanic arc
    Nature (IF 42.778) Pub Date : 2020-06-24
    George F. Cooper; Colin G. Macpherson; Jon D. Blundy; Benjamin Maunder; Robert W. Allen; Saskia Goes; Jenny S Collier; Lidong Bie; Nicholas Harmon; Stephen P. Hicks; Alexander A. Iveson; Julie Prytulak; Andreas Rietbrock; Catherine A. Rychert; Jon P. Davidson

    Oceanic lithosphere carries volatiles, notably water, into the mantle through subduction at convergent plate boundaries. This subducted water exercises control on the production of magma, earthquakes, formation of continental crust and mineral resources. Identifying different potential fluid sources (sediments, crust and mantle lithosphere) and tracing fluids from their release to the surface has proved

    更新日期:2020-06-24
  • Chromosomal alterations among age-related haematopoietic clones in Japan
    Nature (IF 42.778) Pub Date : 2020-06-24
    Chikashi Terao; Akari Suzuki; Yukihide Momozawa; Masato Akiyama; Kazuyoshi Ishigaki; Kazuhiko Yamamoto; Koichi Matsuda; Yoshinori Murakami; Steven A. McCarroll; Michiaki Kubo; Po-Ru Loh; Yoichiro Kamatani

    The extent to which the biology of oncogenesis and ageing are shaped by factors that distinguish human populations is unknown. Haematopoietic clones with acquired mutations become common with advancing age and can lead to blood cancers1,2,3,4,5,6,7,8,9,10. Here we describe shared and population-specific patterns of genomic mutations and clonal selection in haematopoietic cells on the basis of 33,250 autosomal

    更新日期:2020-06-24
  • Ultralow-dielectric-constant amorphous boron nitride
    Nature (IF 42.778) Pub Date : 2020-06-24
    Seokmo Hong; Chang-Seok Lee; Min-Hyun Lee; Yeongdong Lee; Kyung Yeol Ma; Gwangwoo Kim; Seong In Yoon; Kyuwook Ihm; Ki-Jeong Kim; Tae Joo Shin; Sang Won Kim; Eun-chae Jeon; Hansol Jeon; Ju-Young Kim; Hyung-Ik Lee; Zonghoon Lee; Aleandro Antidormi; Stephan Roche; Manish Chhowalla; Hyeon-Jin Shin; Hyeon Suk Shin

    Decrease in processing speed due to increased resistance and capacitance delay is a major obstacle for the down-scaling of electronics1,2,3. Minimizing the dimensions of interconnects (metal wires that connect different electronic components on a chip) is crucial for the miniaturization of devices. Interconnects are isolated from each other by non-conducting (dielectric) layers. So far, research has

    更新日期:2020-06-24
  • Fluorescent bicolour sensor for low-background neutrinoless double β decay experiments.
    Nature (IF 42.778) Pub Date : 2020-06-22
    Iván Rivilla,Borja Aparicio,Juan M Bueno,David Casanova,Claire Tonnelé,Zoraida Freixa,Pablo Herrero,Celia Rogero,José I Miranda,Rosa M Martínez-Ojeda,Francesc Monrabal,Beñat Olave,Thomas Schäfer,Pablo Artal,David Nygren,Fernando P Cossío,Juan J Gómez-Cadenas

    Observation of the neutrinoless double β decay is the only practical way to establish that neutrinos are their own antiparticles1. Because of the small masses of neutrinos, the lifetime of neutrinoless double β decay is expected to be at least ten orders of magnitude greater than the typical lifetimes of natural radioactive chains, which can mimic the experimental signature of neutrinoless double β

    更新日期:2020-06-22
  • Convergent antibody responses to SARS-CoV-2 in convalescent individuals.
    Nature (IF 42.778) Pub Date : 2020-06-18
    Davide F Robbiani,Christian Gaebler,Frauke Muecksch,Julio C C Lorenzi,Zijun Wang,Alice Cho,Marianna Agudelo,Christopher O Barnes,Anna Gazumyan,Shlomo Finkin,Thomas Hägglöf,Thiago Y Oliveira,Charlotte Viant,Arlene Hurley,Hans-Heinrich Hoffmann,Katrina G Millard,Rhonda G Kost,Melissa Cipolla,Kristie Gordon,Filippo Bianchini,Spencer T Chen,Victor Ramos,Roshni Patel,Juan Dizon,Irina Shimeliovich,Pilar

    During the COVID-19 pandemic, SARS-CoV-2 infected millions of people and claimed hundreds of thousands of lives. Virus entry into cells depends on the receptor binding domain (RBD) of the SARS-CoV-2 spike protein (S). Although there is no vaccine, it is likely that antibodies will be essential for protection. However, little is known about the human antibody response to SARS-CoV-21–5. Here we report

    更新日期:2020-06-18
  • Integrated turnkey soliton microcombs.
    Nature (IF 42.778) Pub Date : 2020-06-17
    Boqiang Shen,Lin Chang,Junqiu Liu,Heming Wang,Qi-Fan Yang,Chao Xiang,Rui Ning Wang,Jijun He,Tianyi Liu,Weiqiang Xie,Joel Guo,David Kinghorn,Lue Wu,Qing-Xin Ji,Tobias J Kippenberg,Kerry Vahala,John E Bowers

    Optical frequency combs have a wide range of applications in science and technology1. An important development for miniature and integrated comb systems is the formation of dissipative Kerr solitons in coherently pumped high-quality-factor optical microresonators2,3,4,5,6,7,8,9. Such soliton microcombs10 have been applied to spectroscopy11,12,13, the search for exoplanets14,15, optical frequency synthesis16

    更新日期:2020-06-17
  • The first dinosaur egg was soft.
    Nature (IF 42.778) Pub Date : 2020-06-17
    Mark A Norell,Jasmina Wiemann,Matteo Fabbri,Congyu Yu,Claudia A Marsicano,Anita Moore-Nall,David J Varricchio,Diego Pol,Darla K Zelenitsky

    Calcified eggshells protect developing embryos against environmental stress and contribute to reproductive success1. As modern crocodilians and birds lay hard-shelled eggs, this eggshell type has been inferred for non-avian dinosaurs. Known dinosaur eggshells are characterized by an innermost membrane, an overlying protein matrix containing calcite, and an outermost waxy cuticle2,3,4,5,6,7. The calcitic

    更新日期:2020-06-17
Contents have been reproduced by permission of the publishers.
导出
全部期刊列表>>
材料学研究精选
Springer Nature Live 产业与创新线上学术论坛
胸腔和胸部成像专题
自然科研论文编辑服务
ACS ES&T Engineering
ACS ES&T Water
屿渡论文,编辑服务
杨超勇
周一歌
华东师范大学
南京工业大学
清华大学
中科大
唐勇
跟Nature、Science文章学绘图
隐藏1h前已浏览文章
中洪博元
课题组网站
新版X-MOL期刊搜索和高级搜索功能介绍
ACS材料视界
x-mol收录
福州大学
南京大学
王杰
左智伟
湖南大学
清华大学
吴杰
赵延川
中山大学化学工程与技术学院
试剂库存
天合科研
down
wechat
bug