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Reply to Chen et al.: Soil organic carbon stocks and persistence of surface 30 cm of Mollisols Proc. Natl. Acad. Sci. U.S.A. (IF 11.205) Pub Date : 2022-06-23 Yichao RuiRandall D. JacksonM. Francesca CotrufoGregg R. SanfordBrian J. SpiesmanLeonardo DeissSteven W. CulmanChao LiangMatthew D. RuarkaDepartment of Soil Science, University of Wisconsin–Madison, Madison, WI 53706bResearch Department, Rodale Institute, Kutztown, PA 19530cDepartment of Agronomy, University of Wisconsin–Madison, Madison, WI 53706dDepartment of Soil and Crop Sciences, Colorado State
Proceedings of the National Academy of Sciences, Volume 119, Issue 28, July 2022.
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Depth-dependent responses of soil organic carbon stock under annual and perennial cropping systems Proc. Natl. Acad. Sci. U.S.A. (IF 11.205) Pub Date : 2022-06-23 Ji ChenYiqi LuoThomas KättererJørgen Eivind OlesenaDepartment of Agroecology, Aarhus University, 8830 Tjele, DenmarkbAarhus University Centre for Circular Bioeconomy, Aarhus University, 8830 Tjele, DenmarkciCLIMATE Interdisciplinary Centre for Climate Change, Aarhus University, 4000 Roskilde, DenmarkdCenter for Ecosystem Science and Society and Department of Biological Sciences, Northern Arizona University
Proceedings of the National Academy of Sciences, Volume 119, Issue 28, July 2022.
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Bronchial epithelia from adults and children: SARS-CoV-2 spread via syncytia formation and type III interferon infectivity restriction Proc. Natl. Acad. Sci. U.S.A. (IF 11.205) Pub Date : 2022-06-24 Guillaume BeucherMarie-Lise BlondotAlexis CelleNoémie PiedPatricia Recordon-PinsonPauline EstevesMuriel FaureMathieu MétifiotSabrina LacommeDenis DacheuxDerrick R. RobinsonGernot LängstFabien BeaufilsMarie-Edith LafonPatrick BergerMarc LandryDenis MalvyThomas TrianMarie-Line AndreolaHarald WodrichaUMR 5234, Microbiologie Fondamentale et Pathogénicité, CNRS, Université de Bordeaux, 33076 Bordeaux, FrancebU1045
Proceedings of the National Academy of Sciences, Volume 119, Issue 28, July 2022.
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Posttranslational modifications optimize the ability of SARS-CoV-2 spike for effective interaction with host cell receptors Proc. Natl. Acad. Sci. U.S.A. (IF 11.205) Pub Date : 2022-06-23 Karan KapoorTianle ChenEmad TajkhorshidaTheoretical and Computational Biophysics Group, NIH Center for Macromolecular Modeling and Bioinformatics, Beckman Institute for Advanced Science and Technology, Department of Biochemistry, University of Illinois at Urbana–Champaign, Urbana, IL 61801bCenter for Biophysics and Quantitative Biology, University of Illinois at Urbana Champaign, Urbana, IL 61801
Proceedings of the National Academy of Sciences, Volume 119, Issue 28, July 2022.
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Reply to Zhen and Yu: Cognitive control as questionable proxy for deliberation in honest behaviors Proc. Natl. Acad. Sci. U.S.A. (IF 11.205) Pub Date : 2022-06-21 Gabriele BellucciChongxiang WangLiyang SaiFrank KruegeraDepartment of Computational Neuroscience, Max Planck Institute for Biological Cybernetics, Tubingen 72076, GermanybDepartment of Psychology, Hangzhou Normal University, Hangzhou 311121, ChinacSchool of Systems Biology, George Mason University, Fairfax, VA 22032
Proceedings of the National Academy of Sciences, Volume 119, Issue 27, July 2022.
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Reply to Roy and Pucadyil: A gain of function by a GTPase-impaired Drp1 Proc. Natl. Acad. Sci. U.S.A. (IF 11.205) Pub Date : 2022-06-21 Isabel Pérez-JoverPooja Madan MohanRajesh RamachandranAnna V. ShnyrovaaInstituto Biofisika, University of the Basque Country, 48940 Leioa, SpainbDepartment of Biochemistry and Molecular Biology, University of the Basque Country, 48940 Leioa, SpaincDepartment of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH 44106dCleveland Center for Membrane and Structural Biology, Case
Proceedings of the National Academy of Sciences, Volume 119, Issue 27, July 2022.
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Spontaneous dishonesty does not specifically engage the perigenual anterior cingulate cortex Proc. Natl. Acad. Sci. U.S.A. (IF 11.205) Pub Date : 2022-06-21 Shanshan ZhenRongjun YuaDepartment of Management, Hong Kong Baptist University, Hong Kong, 999077, China
Proceedings of the National Academy of Sciences, Volume 119, Issue 27, July 2022.
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Is Drp1 sufficient to catalyze membrane fission? Proc. Natl. Acad. Sci. U.S.A. (IF 11.205) Pub Date : 2022-06-21 Krishnendu RoyThomas J. PucadyilaDepartment of Biology, Indian Institute of Science Education and Research, Maharashtra, 411008 India
Proceedings of the National Academy of Sciences, Volume 119, Issue 27, July 2022.
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An unexpected function for an ESCRT protein Proc. Natl. Acad. Sci. U.S.A. (IF 11.205) Pub Date : 2022-06-14 Diane C. BasshamaDepartment of Genetics, Development and Cell Biology, Iowa State University, Ames, IA 50011
Proceedings of the National Academy of Sciences, Volume 119, Issue 26, June 2022.
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The sudden swing to a partisan Republican court Proc. Natl. Acad. Sci. U.S.A. (IF 11.205) Pub Date : 2022-06-14 Rogers M. SmithaDepartment of Political Science, University of Pennsylvania, Philadelphia, PA 19104
Proceedings of the National Academy of Sciences, Volume 119, Issue 26, June 2022.
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SARS-CoV-2 couples evasion of inflammatory response to activated nucleotide synthesis Proc. Natl. Acad. Sci. U.S.A. (IF 11.205) Pub Date : 2022-06-14 Chao QinYouliang RaoHao YuanTing-Yu WangJun ZhaoBianca EspinosaYongzhen LiuShu ZhangAli Can SavasQizhi LiuMehrnaz ZarinfarStephanie RiceJill HenleyLucio ComaiNicholas A. GrahamCasey ChenChao ZhangPinghui FengaSection of Infection and Immunity, Herman Ostrow School of Dentistry, Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles
Proceedings of the National Academy of Sciences, Volume 119, Issue 26, June 2022.
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Quantifying the importance and location of SARS-CoV-2 transmission events in large metropolitan areas Proc. Natl. Acad. Sci. U.S.A. (IF 11.205) Pub Date : 2022-06-13 Alberto AletaDavid Martín-CorralMichiel A. BakkerAna Pastore y PionttiMarco AjelliMaria LitvinovaMatteo ChinazziNatalie E. DeanM. Elizabeth HalloranIra M. LonginiAlex PentlandAlessandro VespignaniYamir MorenoEsteban MoroaISI Foundation, 10126 Turin, ItalybDepartamento de Matemáticas, Universidad Carlos III de Madrid, 28911 Leganés, SpaincGrupo Interdisciplinar de Sistemas Complejos, Universidad Carlos
Proceedings of the National Academy of Sciences, Volume 119, Issue 26, June 2022.
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Meeting a threat of the Anthropocene: Taste avoidance of metal ions by Drosophila. Proc. Natl. Acad. Sci. U.S.A. (IF 11.205) Pub Date : 2022-06-14 Shuke Xiao,Lisa S Baik,Xueying Shang,John R Carlson
The Anthropocene Epoch poses a critical challenge for organisms: they must cope with new threats at a rapid rate. These threats include toxic chemical compounds released into the environment by human activities. Here, we examine elevated concentrations of heavy metal ions as an example of anthropogenic stressors. We find that the fruit fly Drosophila avoids nine metal ions when present at elevated
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Fighting force and experience combine to determine contest success in a warlike mammal. Proc. Natl. Acad. Sci. U.S.A. (IF 11.205) Pub Date : 2022-06-14 P A Green,Faye J Thompson,Michael A Cant
Conflicts between social groups or "intergroup contests" are proposed to play a major role in the evolution of cooperation and social organization in humans and some nonhuman animal societies. In humans, success in warfare and other collective conflicts depends on both fighting group size and the presence and actions of key individuals, such as leaders or talismanic warriors. Understanding the determinants
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Multilevel atlas comparisons reveal divergent evolution of the primate brain. Proc. Natl. Acad. Sci. U.S.A. (IF 11.205) Pub Date : 2022-06-14 Clément M Garin,Marie Garin,Leonardo Silenzi,Rye Jaffe,Christos Constantinidis
Whether the size of the prefrontal cortex (PFC) in humans is disproportionate when compared to other species is a persistent debate in evolutionary neuroscience. This question has left the study of over/under-expansion in other structures relatively unexplored. We therefore sought to address this gap by adapting anatomical areas from the digital atlases of 18 mammalian species, to create a common interspecies
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Dystrophin missense mutations alter focal adhesion tension and mechanotransduction. Proc. Natl. Acad. Sci. U.S.A. (IF 11.205) Pub Date : 2022-06-14 Maria Paz Ramirez,Michael J M Anderson,Marcus D Kelly,Lauren J Sundby,Anthony R Hagerty,Sophia J Wenthe,David J Odde,James M Ervasti,Wendy R Gordon
Dystrophin is an essential muscle protein that contributes to cell membrane stability by mechanically linking the actin cytoskeleton to the extracellular matrix via an adhesion complex called the dystrophin-glycoprotein complex. The absence or impaired function of dystrophin causes muscular dystrophy. Focal adhesions (FAs) are also mechanosensitive adhesion complexes that connect the cytoskeleton to
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Dynamics of cross-platform attention to retracted papers. Proc. Natl. Acad. Sci. U.S.A. (IF 11.205) Pub Date : 2022-06-14 Hao Peng,Daniel M Romero,Emőke-Ágnes Horvát
Retracted papers often circulate widely on social media, digital news, and other websites before their official retraction. The spread of potentially inaccurate or misleading results from retracted papers can harm the scientific community and the public. Here, we quantify the amount and type of attention 3,851 retracted papers received over time in different online platforms. Comparing with a set of
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Geological activity shapes the microbiome in deep-subsurface aquifers by advection. Proc. Natl. Acad. Sci. U.S.A. (IF 11.205) Pub Date : 2022-06-13 Yuran Zhang,Roland N Horne,Adam J Hawkins,John Carlo Primo,Oxana Gorbatenko,Anne E Dekas
Subsurface environments host diverse microorganisms in fluid-filled fractures; however, little is known about how geological and hydrological processes shape the subterranean biosphere. Here, we sampled three flowing boreholes weekly for 10 mo in a 1478-m-deep fractured rock aquifer to study the role of fracture activity (defined as seismically or aseismically induced fracture aperture change) and
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Hot and dry conditions predict shorter nestling telomeres in an endangered songbird: Implications for population persistence. Proc. Natl. Acad. Sci. U.S.A. (IF 11.205) Pub Date : 2022-06-13 Justin R Eastwood,Tim Connallon,Kaspar Delhey,Michelle L Hall,Niki Teunissen,Sjouke A Kingma,Ariana M La Porte,Simon Verhulst,Anne Peters
Climate warming is increasingly exposing wildlife to sublethal high temperatures, which may lead to chronic impacts and reduced fitness. Telomere length (TL) may link heat exposure to fitness, particularly at early-life stages, because developing organisms are especially vulnerable to adverse conditions, adversity can shorten telomeres, and TL predicts fitness. Here, we quantify how climatic and environmental
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Raf Kinase Inhibitory Protein regulates the cAMP-dependent protein kinase signaling pathway through a positive feedback loop. Proc. Natl. Acad. Sci. U.S.A. (IF 11.205) Pub Date : 2022-06-13 Jiyoung Lee,Cristina Olivieri,Colin Ong,Larry R Masterson,Suzana Gomes,Bok-Soon Lee,Florian Schaefer,Kristina Lorenz,Gianluigi Veglia,Marsha Rich Rosner
Raf Kinase Inhibitory Protein (RKIP) maintains cellular robustness and prevents the progression of diseases such as cancer and heart disease by regulating key kinase cascades including MAP kinase and protein kinase A (PKA). Phosphorylation of RKIP at S153 by Protein Kinase C (PKC) triggers a switch from inhibition of Raf to inhibition of the G protein coupled receptor kinase 2 (GRK2), enhancing signaling
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Lithiating magneto-ionics in a rechargeable battery. Proc. Natl. Acad. Sci. U.S.A. (IF 11.205) Pub Date : 2022-06-13 Yong Hu,Weiyi Gong,Sichen Wei,Saurabh Khuje,Yulong Huang,Zheng Li,Yuguang C Li,Fei Yao,Qimin Yan,Shenqiang Ren
Magneto-ionics, real-time ionic control of magnetism in solid-state materials, promise ultralow-power memory, computing, and ultralow-field sensor technologies. The real-time ion intercalation is also the key state-of-charge feature in rechargeable batteries. Here, we report that the reversible lithiation/delithiation in molecular magneto-ionic material, the cathode in a rechargeable lithium-ion battery
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Expansion of a retrovirus lineage in the koala genome. Proc. Natl. Acad. Sci. U.S.A. (IF 11.205) Pub Date : 2022-06-13 Mette Lillie,Jason Hill,Mats E Pettersson,Patric Jern
Retroviruses have left their legacy in host genomes over millions of years as endogenous retroviruses (ERVs), and their structure, diversity, and prevalence provide insights into the historical dynamics of retrovirus-host interactions. In bioinformatic analyses of koala (Phascolarctos cinereus) whole-genome sequences, we identify a recently expanded ERV lineage (phaCin-β) that is related to the New
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Radioresistant cells initiate lymphocyte-dependent lung inflammation and IFNγ-dependent mortality in STING gain-of-function mice. Proc. Natl. Acad. Sci. U.S.A. (IF 11.205) Pub Date : 2022-06-13 Kevin MingJie Gao,Mona Motwani,Thomas Tedder,Ann Marshak-Rothstein,Katherine A Fitzgerald
Pediatric patients with constitutively active mutations in the cytosolic double-stranded-DNA-sensing adaptor STING develop an autoinflammatory syndrome known as STING-associated vasculopathy with onset in infancy (SAVI). SAVI patients have elevated interferon-stimulated gene expression and suffer from interstitial lung disease (ILD) with lymphocyte predominate bronchus-associated lymphoid tissue (BALT)
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Memory-like NK cells armed with a neoepitope-specific CAR exhibit potent activity against NPM1 mutated acute myeloid leukemia. Proc. Natl. Acad. Sci. U.S.A. (IF 11.205) Pub Date : 2022-06-13 Han Dong,James Dongjoo Ham,Guangan Hu,Guozhu Xie,Juliana Vergara,Yong Liang,Alaa Ali,Mubin Tarannum,Hannah Donner,Joanna Baginska,Yasmin Abdulhamid,Khanhlinh Dinh,Robert J Soiffer,Jerome Ritz,Laurie H Glimcher,Jianzhu Chen,Rizwan Romee
Acute myeloid leukemia (AML) remains a therapeutic challenge, and a paucity of tumor-specific targets has significantly hampered the development of effective immune-based therapies. Recent paradigm-changing studies have shown that natural killer (NK) cells exhibit innate memory upon brief activation with IL-12 and IL-18, leading to cytokine-induced memory-like (CIML) NK cell differentiation. CIML NK
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Hidden signatures of early fire at Evron Quarry (1.0 to 0.8 Mya). Proc. Natl. Acad. Sci. U.S.A. (IF 11.205) Pub Date : 2022-06-13 Zane Stepka,Ido Azuri,Liora Kolska Horwitz,Michael Chazan,Filipe Natalio
Pyrotechnology is a key element of hominin evolution. The identification of fire in early hominin sites relies primarily on an initial visual assessment of artifacts' physical alterations, resulting in potential underestimation of the prevalence of fire in the archaeological record. Here, we used a suite of spectroscopic techniques to counter the absence of visual signatures for fire and demonstrate
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Structural basis for ultrapotent antibody-mediated neutralization of human metapneumovirus. Proc. Natl. Acad. Sci. U.S.A. (IF 11.205) Pub Date : 2022-06-13 Avik Banerjee,Jiachen Huang,Scott A Rush,Jackelyn Murray,Aaron D Gingerich,Fredejah Royer,Ching-Lin Hsieh,Ralph A Tripp,Jason S McLellan,Jarrod J Mousa
Human metapneumovirus (hMPV) is a leading cause of morbidity and hospitalization among children worldwide, however, no vaccines or therapeutics are currently available for hMPV disease prevention and treatment. The hMPV fusion (F) protein is the sole target of neutralizing antibodies. To map the immunodominant epitopes on the hMPV F protein, we isolated a panel of human monoclonal antibodies (mAbs)
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Host protease activity classifies pneumonia etiology. Proc. Natl. Acad. Sci. U.S.A. (IF 11.205) Pub Date : 2022-06-13 Melodi Anahtar,Leslie W Chan,Henry Ko,Aditya Rao,Ava P Soleimany,Purvesh Khatri,Sangeeta N Bhatia
Community-acquired pneumonia (CAP) has been brought to the forefront of global health priorities due to the COVID-19 pandemic. However, classification of viral versus bacterial pneumonia etiology remains a significant clinical challenge. To this end, we have engineered a panel of activity-based nanosensors that detect the dysregulated activity of pulmonary host proteases implicated in the response
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Universal healthcare as pandemic preparedness: The lives and costs that could have been saved during the COVID-19 pandemic. Proc. Natl. Acad. Sci. U.S.A. (IF 11.205) Pub Date : 2022-06-13 Alison P Galvani,Alyssa S Parpia,Abhishek Pandey,Pratha Sah,Kenneth Colón,Gerald Friedman,Travis Campbell,James G Kahn,Burton H Singer,Meagan C Fitzpatrick
The fragmented and inefficient healthcare system in the United States leads to many preventable deaths and unnecessary costs every year. During a pandemic, the lives saved and economic benefits of a single-payer universal healthcare system relative to the status quo would be even greater. For Americans who are uninsured and underinsured, financial barriers to COVID-19 care delayed diagnosis and exacerbated
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Genome-wide analysis of the in vivo tRNA structurome reveals RNA structural and modification dynamics under heat stress. Proc. Natl. Acad. Sci. U.S.A. (IF 11.205) Pub Date : 2022-06-13 Ryota Yamagami,Jacob P Sieg,Sarah M Assmann,Philip C Bevilacqua
RNA structure plays roles in myriad cellular events including transcription, translation, and RNA processing. Genome-wide analyses of RNA secondary structure in vivo by chemical probing have revealed critical structural features of mRNAs and long ncRNAs. Here, we examine the in vivo secondary structure of a small RNA class, tRNAs. Study of tRNA structure is challenging because tRNAs are heavily modified
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Revealing the recent demographic history of Europe via haplotype sharing in the UK Biobank. Proc. Natl. Acad. Sci. U.S.A. (IF 11.205) Pub Date : 2022-06-13 Edmund Gilbert,Ashwini Shanmugam,Gianpiero L Cavalleri
Haplotype-based analyses have recently been leveraged to interrogate the fine-scale structure in specific geographic regions, notably in Europe, although an equivalent haplotype-based understanding across the whole of Europe with these tools is lacking. Furthermore, study of identity-by-descent (IBD) sharing in a large sample of haplotypes across Europe would allow a direct comparison between different
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Temporal relations between peripheral and central arousals in good and poor sleepers. Proc. Natl. Acad. Sci. U.S.A. (IF 11.205) Pub Date : 2022-06-13 Ana Ribeiro,Rachel Gabriel,Bernardo Garcia,Casey Cuccio,William Aqeel,Alejandro Moreno,Colby Landeen,Arlene Hurley,Neil Kavey,Donald Pfaff
Good sleepers and patients with insomnia symptoms (poor sleepers) were tracked with two measures of arousal; conventional polysomnography (PSG) for electroencephalogram (EEG) assessed cortical arousals, and a peripheral arterial tonometry device was used for the detection of peripheral nervous system (PNS) arousals associated with vasoconstrictions. The relationship between central (cortical) and peripheral
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Heterogeneous lattice strain strengthening in severely distorted crystalline solids. Proc. Natl. Acad. Sci. U.S.A. (IF 11.205) Pub Date : 2022-06-13 Jia Li,Yang Chen,Quanfeng He,Xiandong Xu,Hang Wang,Chao Jiang,Bin Liu,Qihong Fang,Yong Liu,Yong Yang,Peter K Liaw,Chain T Liu
Multi-principal element alloys (MPEAs) exhibit outstanding mechanical properties because the core effect of severe atomic lattice distortion is distinctly different from that of traditional alloys. However, at the mesoscopic scale the underlying physics for the abundant dislocation activities responsible for strength-ductility synergy has not been uncovered. While the Eshelby mean-field approaches
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Transcriptional and functional motifs defining renal function revealed by single-nucleus RNA sequencing. Proc. Natl. Acad. Sci. U.S.A. (IF 11.205) Pub Date : 2022-06-13 Jun Xu,Yifang Liu,Hongjie Li,Alexander J Tarashansky,Colin H Kalicki,Ruei-Jiun Hung,Yanhui Hu,Aram Comjean,Sai Saroja Kolluru,Bo Wang,Stephen R Quake,Liqun Luo,Andrew P McMahon,Julian A T Dow,Norbert Perrimon
Recent advances in single-cell sequencing provide a unique opportunity to gain novel insights into the diversity, lineage, and functions of cell types constituting a tissue/organ. Here, we performed a single-nucleus study of the adult Drosophila renal system, consisting of Malpighian tubules and nephrocytes, which shares similarities with the mammalian kidney. We identified 11 distinct clusters representing
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Antiactivators prevent self-sensing in Pseudomonas aeruginosa quorum sensing. Proc. Natl. Acad. Sci. U.S.A. (IF 11.205) Pub Date : 2022-06-13 Parker Smith,Martin Schuster
Quorum sensing is described as a widespread cell density-dependent signaling mechanism in bacteria. Groups of cells coordinate gene expression by secreting and responding to diffusible signal molecules. Theory, however, predicts that individual cells may short-circuit this mechanism by directly responding to the signals they produce irrespective of cell density. In this study, we characterize this
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Cooperative redox and spin activity from three redox congeners of sulfur-bridged iron nitrosyl and nickel dithiolene complexes. Proc. Natl. Acad. Sci. U.S.A. (IF 11.205) Pub Date : 2022-06-13 Manuel Quiroz,Molly M Lockart,Mohamed R Saber,Shaik Waseem Vali,Lindy C Elrod,Brad S Pierce,Michael B Hall,Marcetta Y Darensbourg
The synthesis of sulfur-bridged Fe-Ni heterobimetallics was inspired by Nature's strategies to "trick" abundant first row transition metals into enabling 2-electron processes: redox-active ligands (including pendant iron-sulfur clusters) and proximal metals. Our design to have redox-active ligands on each metal, NO on iron and dithiolene on nickel, resulted in the observation of unexpectedly intricate
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Male mastodon landscape use changed with maturation (late Pleistocene, North America). Proc. Natl. Acad. Sci. U.S.A. (IF 11.205) Pub Date : 2022-06-13 Joshua H Miller,Daniel C Fisher,Brooke E Crowley,Ross Secord,Bledar A Konomi
Under harsh Pleistocene climates, migration and other forms of seasonally patterned landscape use were likely critical for reproductive success of mastodons (Mammut americanum) and other megafauna. However, little is known about how their geographic ranges and mobility fluctuated seasonally or changed with sexual maturity. We used a spatially explicit movement model that coupled strontium and oxygen
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Lung surfactant negatively affects the photodynamic inactivation of bacteria-in vitro and molecular dynamic simulation analyses. Proc. Natl. Acad. Sci. U.S.A. (IF 11.205) Pub Date : 2022-06-13 Giulia Kassab,Johan Sebastian Diaz Tovar,Lucas Miguel Pereira Souza,Rayla Kelly Magalhães Costa,Rudielson Santos Silva,André Silva Pimentel,Cristina Kurachi,Vanderlei Salvador Bagnato
In the context of the rapid increase of antibiotic-resistant infections, in particular of pneumonia, antimicrobial photodynamic therapy (aPDT), the microbiological application of photodynamic therapy (PDT), comes in as a promising treatment alternative since the induced damage and resultant death are not dependent on a specific biomolecule or cellular pathway. The applicability of aPDT using the photosensitizer
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Functional evidence supports adaptive plant chemical defense along a geographical cline. Proc. Natl. Acad. Sci. U.S.A. (IF 11.205) Pub Date : 2022-06-13 Anurag A Agrawal,Laura Espinosa Del Alba,Xosé López-Goldar,Amy P Hastings,Ronald A White,Rayko Halitschke,Susanne Dobler,Georg Petschenka,Christophe Duplais
Environmental clines in organismal defensive traits are usually attributed to stronger selection by enemies at lower latitudes or near the host's range center. Nonetheless, little functional evidence has supported this hypothesis, especially for coevolving plants and herbivores. We quantified cardenolide toxins in seeds of 24 populations of common milkweed (Asclepias syriaca) across 13 degrees of latitude
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Sialic acids on B cells are crucial for their survival and provide protection against apoptosis. Proc. Natl. Acad. Sci. U.S.A. (IF 11.205) Pub Date : 2022-06-13 Alexandra T Linder,Michael Schmidt,Julia Hitschfel,Markus Abeln,Pascal Schneider,Rita Gerardy-Schahn,Anja K Münster-Kühnel,Lars Nitschke
Sialic acids (Sias) on the B cell membrane are involved in cell migration, in the control of the complement system and, as sialic acid-binding immunoglobulin-like lectin (Siglec) ligands, in the regulation of cellular signaling. We studied the role of sialoglycans on B cells in a mouse model with B cell-specific deletion of cytidine monophosphate sialic acid synthase (CMAS), the enzyme essential for
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Whiskers as hydrodynamic prey sensors in foraging seals. Proc. Natl. Acad. Sci. U.S.A. (IF 11.205) Pub Date : 2022-06-13 Taiki Adachi,Yasuhiko Naito,Patrick W Robinson,Daniel P Costa,Luis A Hückstädt,Rachel R Holser,Wataru Iwasaki,Akinori Takahashi
The darkness of the deep ocean limits the vision of diving predators, except when prey emit bioluminescence. It is hypothesized that deep-diving seals rely on highly developed whiskers to locate their prey. However, if and how seals use their whiskers while foraging in natural conditions remains unknown. We used animal-borne tags to show that free-ranging elephant seals use their whiskers for hydrodynamic
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Indole-3-pyruvic acid regulates TAA1 activity, which plays a key role in coordinating the two steps of auxin biosynthesis. Proc. Natl. Acad. Sci. U.S.A. (IF 11.205) Pub Date : 2022-06-13 Akiko Sato,Kazuo Soeno,Rie Kikuchi,Megumi Narukawa-Nara,Chiaki Yamazaki,Yusuke Kakei,Ayako Nakamura,Yukihisa Shimada
Auxin biosynthesis involves two types of enzymes: the Trp aminotransferases (TAA/TARs) and the flavin monooxygenases (YUCCAs). This two-step pathway is highly conserved throughout the plant kingdom and is essential for almost all of the major developmental processes. Despite their importance, it is unclear how these enzymes are regulated and how their activities are coordinated. Here, we show that
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Voltage-gated proton channels explain coccolithophore sensitivity to ocean acidification Proc. Natl. Acad. Sci. U.S.A. (IF 11.205) Pub Date : 2022-06-10 Peter von DassowaDepartamento de Ecología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, 8331150 Santiago, ChilebInstituto Milenio de Oceanografía, 4070386 Concepción, ChilecDipartimento Ecologia Marina Integrata, Stazione Zoologica Anton Dohrn, 80121 Naples, Italy
Proceedings of the National Academy of Sciences, Volume 119, Issue 25, June 2022.
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Evolving alternative neural pathways for vocal dexterity Proc. Natl. Acad. Sci. U.S.A. (IF 11.205) Pub Date : 2022-06-10 Yisi S. ZhangAsif A. GhazanfaraPrinceton Neuroscience Institute, Princeton University, Princeton, NJ 08544
Proceedings of the National Academy of Sciences, Volume 119, Issue 25, June 2022.
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Closing the loop on crowdsourced science Proc. Natl. Acad. Sci. U.S.A. (IF 11.205) Pub Date : 2022-06-10 James M. RobsonAlexander A. GreenaDepartment of Biomedical Engineering, Boston University, Boston, MA 02215bBiological Design Center, Boston University, Boston, MA 02215cMolecular Biology, Cell Biology & Biochemistry Program, Graduate School of Arts and Sciences, Boston University, Boston, MA 02215
Proceedings of the National Academy of Sciences, Volume 119, Issue 25, June 2022.
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Chemotactic self-caging in active emulsions Proc. Natl. Acad. Sci. U.S.A. (IF 11.205) Pub Date : 2022-06-09 Babak Vajdi HokmabadJaime Agudo-CanalejoSuropriya SahaRamin GolestanianCorinna C. MaassaDepartment of Complex Fluids, Max Planck Institute for Dynamics and Self-Organization, 37077 Göttingen, GermanybInstitute for the Dynamics of Complex Systems, Georg August Universität, 37077 Göttingen, GermanycDepartment of Living Matter, Max Planck Institute for Dynamics and Self-Organization, 37077 Göttingen,
Proceedings of the National Academy of Sciences, Volume 119, Issue 24, June 2022.
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Intranasal inoculation of an MVA-based vaccine induces IgA and protects the respiratory tract of hACE2 mice from SARS-CoV-2 infection Proc. Natl. Acad. Sci. U.S.A. (IF 11.205) Pub Date : 2022-06-09 Jeffrey L. AmericoCatherine A. CotterPatricia L. EarlRuikang LiuBernard MossaLaboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892
Proceedings of the National Academy of Sciences, Volume 119, Issue 24, June 2022.
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Antimicrobial second skin using copper nanomesh Proc. Natl. Acad. Sci. U.S.A. (IF 11.205) Pub Date : 2022-06-09 Jae Joon KimSiyoung HaLina KimYutaro KatoYan WangChihiro OkutaniHaoyang WangChunya WangKenjiro FukudaSunghoon LeeTomoyuki YokotaOh Seok KwonTakao SomeyaaDepartment of Electrical Engineering and Information Systems, The University of Tokyo, Bunkyo-Ku, Tokyo 113-8656, JapanbInfectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, South KoreacCenter
Proceedings of the National Academy of Sciences, Volume 119, Issue 24, June 2022.
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Programming and training rate-independent chemical reaction networks Proc. Natl. Acad. Sci. U.S.A. (IF 11.205) Pub Date : 2022-06-09 Marko VasićCameron ChalkAustin LuchsingerSarfraz KhurshidDavid SoloveichikaElectrical and Computer Engineering, The University of Texas at Austin, Austin, TX 78712
Proceedings of the National Academy of Sciences, Volume 119, Issue 24, June 2022.
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Harnessing interpretable and unsupervised machine learning to address big data from modern X-ray diffraction Proc. Natl. Acad. Sci. U.S.A. (IF 11.205) Pub Date : 2022-06-09 Jordan VenderleyKrishnanand MallayyaMichael MattyMatthew KrogstadJacob RuffGeoff PleissVarsha KishoreDavid MandrusDaniel PhelanLekhanath PoudelAndrew Gordon WilsonKilian WeinbergerPuspa UpretiMichael NormanStephan RosenkranzRaymond OsbornEun-Ah KimaDepartment of Physics, Cornell University, Ithaca, NY 14853bMaterials Science Division, Argonne National Laboratory, Lemont, IL 60439cCornell High Energy
Proceedings of the National Academy of Sciences, Volume 119, Issue 24, June 2022.
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Terminating spiral waves with a single designed stimulus: Teleportation as the mechanism for defibrillation Proc. Natl. Acad. Sci. U.S.A. (IF 11.205) Pub Date : 2022-06-09 Noah DeTalAbouzar KaboudianFlavio H. FentonaSchool of Physics, Georgia Institute of Technology, Atlanta, GA 30332
Proceedings of the National Academy of Sciences, Volume 119, Issue 24, June 2022.
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Dynamical differential covariance recovers directional network structure in multiscale neural systems Proc. Natl. Acad. Sci. U.S.A. (IF 11.205) Pub Date : 2022-06-09 Yusi ChenBurke Q. RosenTerrence J. SejnowskiaComputational Neurobiology Laboratory, Salk Institute for Biological Sciences, La Jolla, CA 92037bSection of Neurobiology, Division of Biological Sciences, University of California San Diego, La Jolla, CA 92093cNeurosciences Graduate Program, University of California San Diego, La Jolla, CA 92093dInstitute for Neural Computation, University of California
Proceedings of the National Academy of Sciences, Volume 119, Issue 24, June 2022.
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One lesson of COVID-19: Conduct more health policy trials Proc. Natl. Acad. Sci. U.S.A. (IF 11.205) Pub Date : 2022-06-09 Luchuo Engelbert BainAstrid Berner-RodoredaShannon A. McMahonMalabika SarkerFrank TanserTill BärnighausenDaniel WiklerNir EyalaLincoln International Institute for Rural Health (LIIRH), University of Lincoln, Lincoln LN6 7TS, United KingdombHeidelberg Institute of Global Health (HIGH), Faculty of Medicine and University Hospital, Heidelberg University, 69117 Heidelberg, GermanycJohns Hopkins Bloomberg
Proceedings of the National Academy of Sciences, Volume 119, Issue 24, June 2022.
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On the optimal management of environmental stock externalities. Proc. Natl. Acad. Sci. U.S.A. (IF 11.205) Pub Date : 2022-06-10 Anastasios Xepapadeas
Following a brief review of the management of environmental externalities under strategic interactions in the traditional temporal domain, results are extended to the spatiotemporal domain. Conditions for spatial open-loop and feedback Nash equilibria, along with conditions for the benchmark cooperative solution, are presented and compared. A simplified numerical example illustrates the spatial patterns
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A genetic mammalian proportional-integral feedback control circuit for robust and precise gene regulation. Proc. Natl. Acad. Sci. U.S.A. (IF 11.205) Pub Date : 2022-06-10 Timothy Frei,Ching-Hsiang Chang,Maurice Filo,Asterios Arampatzis,Mustafa Khammash
The processes that keep a cell alive are constantly challenged by unpredictable changes in its environment. Cells manage to counteract these changes by employing sophisticated regulatory strategies that maintain a steady internal milieu. Recently, the antithetic integral feedback motif has been demonstrated to be a minimal and universal biological regulatory strategy that can guarantee robust perfect
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Screening membraneless organelle participants with machine-learning models that integrate multimodal features. Proc. Natl. Acad. Sci. U.S.A. (IF 11.205) Pub Date : 2022-06-10 Zhaoming Chen,Chao Hou,Liang Wang,Chunyu Yu,Taoyu Chen,Boyan Shen,Yaoyao Hou,Pilong Li,Tingting Li
Protein self-assembly is one of the formation mechanisms of biomolecular condensates. However, most phase-separating systems (PS) demand multiple partners in biological conditions. In this study, we divided PS proteins into two groups according to the mechanism by which they undergo PS: PS-Self proteins can self-assemble spontaneously to form droplets, while PS-Part proteins interact with partners
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QnAs with Leah H. Somerville Proc. Natl. Acad. Sci. U.S.A. (IF 11.205) Pub Date : 2022-06-07 Matthew Hardcastle
Proceedings of the National Academy of Sciences, Volume 119, Issue 24, June 2022.
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Correction for Friedman et al., Microbes vs. chemistry in the origin of the anaerobic gut lumen Proc. Natl. Acad. Sci. U.S.A. (IF 11.205) Pub Date : 2022-06-06
Proceedings of the National Academy of Sciences, Volume 119, Issue 24, June 2022.
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Correction for Xie et al., Indirect influence in social networks as an induced percolation phenomenon Proc. Natl. Acad. Sci. U.S.A. (IF 11.205) Pub Date : 2022-06-06
Proceedings of the National Academy of Sciences, Volume 119, Issue 24, June 2022.
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Correction for Luque et al., Cryo-EM structures show the mechanistic basis of pan-peptidase inhibition by human α2-macroglobulin Proc. Natl. Acad. Sci. U.S.A. (IF 11.205) Pub Date : 2022-06-07
Proceedings of the National Academy of Sciences, Volume 119, Issue 24, June 2022.
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Acute stress promotes brain network integration and reduces state transition variability Proc. Natl. Acad. Sci. U.S.A. (IF 11.205) Pub Date : 2022-06-06 Rong WangShanshan ZhenChangsong ZhouRongjun YuaCollege of Science, Xi’an University of Science and Technology, Xi’an 710054, ChinabDepartment of Physics, Centre for Nonlinear Studies, Beijing–Hong Kong–Singapore Joint Centre for Nonlinear and Complex Systems (Hong Kong), Institute of Computational and Theoretical Studies, Hong Kong Baptist University, Hong KongcDepartment of Management, Hong Kong Baptist
Proceedings of the National Academy of Sciences, Volume 119, Issue 24, June 2022.