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Acquisition of quaternary trimer interaction as a key step in the lineage maturation of a broad and potent HIV-1 neutralizing antibody Structure (IF 4.4) Pub Date : 2025-05-23 Qingbo Liu, Ruth J. Parsons, Kevin Wiehe, Robert J. Edwards, Kevin O. Saunders, Peng Zhang, Huiyi Miao, Kedamawit Tilahun, Julia Jones, Yue Chen, Bhavna Hora, Wilton B. Williams, David Easterhoff, Xiao Huang, Katarzyna Janowska, Katayoun Mansouri, Barton F. Haynes, Priyamvada Acharya, Paolo Lusso
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Unprocessed BMP9 precursor is an intrinsic antagonist for its active growth factor Structure (IF 4.4) Pub Date : 2025-05-23 Weida Zhang, Yuanyuan Zhang, Weidong Mao, Tao Huang, Xinrong Yu, Xiaohong Qin, Li-Zhi Mi
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Multiple steps of dynein activation by Lis1 visualized by cryo-EM Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2025-05-23 Agnieszka A. Kendrick, Kendrick H. V. Nguyen, Wen Ma, Eva P. Karasmanis, Rommie E. Amaro, Samara L. Reck-Peterson, Andres E. Leschziner
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Structural elucidation of full-length Pfs48/45 in complex with potent monoclonal antibodies isolated from a naturally exposed individual Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2025-05-22 Iga Kucharska, Danton Ivanochko, Sophia Hailemariam, Maartje R. Inklaar, Hee Ryung Kim, Karina Teelen, Rianne Stoter, Marga van de Vegte-Bolmer, Geert-Jan van Gemert, Anthony Semesi, Brandon McLeod, Ahyoung Ki, Won-Kyu Lee, John L. Rubinstein, Matthijs M. Jore, Jean-Philippe Julien
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Chloride binding does not influence prestin motor speed at very high frequencies in the mouse outer hair cell Structure (IF 4.4) Pub Date : 2025-05-21 Jun-Ping Bai, Chenou Zhang, Iman Bahader, Nicola Strenzke, Vijay Renigunta, Dominik Oliver, Dhasakumar Navaratnam, Oliver Beckstein, Joseph Santos-Sacchi
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The molecular mechanisms of visual chromophore release from cellular retinaldehyde-binding protein Structure (IF 4.4) Pub Date : 2025-05-21 Daniel Santos, Lorenzo Foglia, Philip D. Kiser, Alvin Yu
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The yin yang of transcriptional memory Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2025-05-21 Alejandra Laguillo-Diego, Effie Apostolou
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Pairwise Encounters Boost Bacterial Motion by Transient Velocity Spikes. Biophys. J. (IF 3.2) Pub Date : 2025-05-21 Pu Feng,Chen Gui,Gancheng Wang,Lingling Wang,Jinglei Hu,Xiangjun Gong,Guangzhao Zhang
For swimming bacteria near surfaces, pairwise encounters inevitably occur and impact their social behavior. However, we know little about how the encounter events influence bacterial dynamics due to the limitations in tracking interplaying bacteria in 3D. Herein, we elucidated the motions of encountering E. coli using a combination of 3D holographic tracking experiments and hydrodynamic simulations
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Extrinsic heterogeneity: Collectivity in isotropic conformational fluctuations of chromosomes. Biophys. J. (IF 3.2) Pub Date : 2025-05-21 Takuya Nara,Haruko Takahashi,Akinori Awazu,Yutaka Kikuchi
Eukaryotic interphase chromosomes maintain a three-dimensional conformation within the nucleus and undergo fluctuations. However, the analysis of chromosome conformational fluctuations has been mainly limited to chromosome conformation capture data that record the contact frequencies between chromosomal regions. Herein, we investigated chromosome fluctuations as polymers based on experimental data
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How we peer review structural data Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2025-05-19
We explain why we ask our authors to provide structural data prior to peer review.
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Image-processing methods for electron microscopy of biological specimens. Acta Cryst. D (IF 2.6) Pub Date : 2025-06-01 Carlos Oscar S Sorzano,Albert Bartesaghi,Amit Singer
The focused issue on Image-processing methods for electron microscopy of biological specimens is introduced. The virtual issue is available at https://journals.iucr.org/special_issues/2025/imageprocessing.
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Thermodynamics of Arginine Interactions with Organic Phosphates. Biophys. J. (IF 3.2) Pub Date : 2025-05-20 Jiyeon Min,Madolyn Britt,Bernard R Brooks,Sergei Sukharev,Jeffery B Klauda
The thermodynamics of arginine-phosphate binding is key to cellular signaling, protein-nucleic acid interactions, and membrane protein dynamics. In biomolecules, monoester phosphates are typically employed as strong electrostatic anchors strategically placed in switch domains to mediate specific interactions. In the diester configuration, phosphate groups act as ubiquitous connectors in all nucleic
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Structure, assembly and inhibition of the Toxoplasma gondii respiratory chain supercomplex Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2025-05-19 Andrew E. MacLean, Shikha Shikha, Mariana Ferreira Silva, Max J. Gramelspacher, Aaron Nilsen, Katherine M. Liebman, Sovitj Pou, Rolf W. Winter, Amit Meir, Michael K. Riscoe, J. Stone Doggett, Lilach Sheiner, Alexander Mühleip
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The molecular mechanism of ATP synthase constrains the evolutionary landscape of chemiosmosis. Biophys. J. (IF 3.2) Pub Date : 2025-05-19 J Emyr Macdonald,Paul D Ashby
ATP synthase, the enzyme responsible for regenerating adenosine triphosphate (ATP) in the cell, comprises a proton-translocating motor in the cell membrane (labelled FO in bacteria, mitochondria and chloroplasts), coupled by a common stalk to a catalytic motor F1 that synthesises or hydrolyses ATP, depending on the direction of rotation. The detailed mechanisms of FO, F1 and their coupling in ATP synthase
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An integrated multiscale computational framework deciphers SARS-CoV-2 resistance to sotrovimab. Biophys. J. (IF 3.2) Pub Date : 2025-05-19 Akshit Sharma,Shweata Maurya,Shivank Kumar,Timir Tripathi,Rajiv K Kar,Aditya K Padhi
The emergence of resistance mutations in the SARS-CoV-2 spike (S) protein presents a challenge for monoclonal antibody treatments like sotrovimab. Understanding the structural, dynamics, and molecular features of these mutations is essential for therapeutic advancements. However, the intricate landscape of potential mutations and critical residues conferring resistance to mAbs like sotrovimab remains
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Structural study on human microbiome-derived polyketide synthases that assemble genotoxic colibactin Structure (IF 4.4) Pub Date : 2025-05-16 Minjae Kim, Jinwoo Kim, Gyu Sung Lee, Paul Dominic B. Olinares, Yougant Airan, Jasmine L. Chow, Jongseok Park, Yujin Jeong, Jiho Park, Brian T. Chait, Seth B. Herzon, Chung Sub Kim, Jin Young Kang
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Jerelle Joseph: seeing biomolecular condensates with computation Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2025-05-16 Melina Casadio
Jerelle Joseph is an assistant professor at the Department of Chemical and Biological Engineering and the Omenn–Darling Bioengineering Institute at Princeton University in New Jersey. We contacted Jerelle to learn about her research priorities, along with her thoughts about the biomolecular condensates field and how computational biology and molecular simulations can fuel discovery.
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DEK–nucleosome structure shows DEK modulates H3K27me3 and stem cell fate Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2025-05-16 Yunfan Shen, Yanhong Liu, Maochao Guo, Song Mao, Rui Chen, Mengran Wang, Zhengbo Li, Yue Li, Wan Chen, Fang Chen, Baixing Wu, Chongyuan Wang, Wei Chen, Huanhuan Cui, Kai Yuan, Hongda Huang
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The importance of physiological and disease contexts in capturing mRNA modifications Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2025-05-16 Audrey Penning, François Fuks
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GID4 Recognition of Pro/N-Degron Peptides: Conformational Selection and Induced Fit. Biophys. J. (IF 3.2) Pub Date : 2025-05-16 Yanjun Zhang,Xule Zhao,Yuxin Tian,Shun Zhang,Feng Fan,Xiafei Hao
The N-degron pathway is essential for protein quality control and cellular homeostasis. GID4, a subunit of the GID ubiquitin ligase, is the main recognition component of the Pro/N-degron pathway. It binds protein substrates through their N-terminal proline, but its binding model and recognition of non-proline residues remain unclear. In this study, we performed molecular dynamics (MD) simulations and
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Measuring PARP1 mobility at DNA damage sites by Segmented Fluorescence Correlation Spectroscopy (FCS). Biophys. J. (IF 3.2) Pub Date : 2025-05-16 Elisa Longo,Greta Paternò,Alberto Diaspro,Luca Lanzanò
Segmented Fluorescence Correlation Spectroscopy (FCS) improves the accuracy of FCS measurements in cells by analyzing data in short temporal segments. We have recently demonstrated the possibility of performing segmented FCS using a commercial confocal laser scanning microscope, enabling the measurement of molecular diffusion in different subcellular regions. In this study, we apply segmented FCS to
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Structural clues about bridge-mediated lipid transfer Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2025-05-15 Pietro De Camilli, Karin M. Reinisch
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Insights into the degradation mechanism of GID4-based proteolysis-targeting chimeras Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2025-05-15
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Reciprocal stabilization of CtBP and TRIM28 represses autophagy to promote metastasis Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2025-05-15 Lixin Tai, Dongliang Zhu, Ping Tang, Jiajia Li, Junyi Li, Peipei Li, Zhonghua Tao, Haipeng Lei, Kai Miao, Hong-xia Wang, Shuhai Lin, Lei Zhang, Man Dou, Yu Han, Han-Ming Shen, Chuxia Deng, Li Wang, Li-jun Di
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Bonding under tension - some cadherins are better than others. Biophys. J. (IF 3.2) Pub Date : 2025-05-15 Eoin McEvoy
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Interplay of Protein Fluctuation and Associated Water Dynamics in Osmolyte Induced Stabilization. Biophys. J. (IF 3.2) Pub Date : 2025-05-15 Kuldeep Singh Negi,Subhajit Rana,Tanmoy Khan,Dipankar Mondal,Pratik Sen
The mechanism behind osmolyte-induced protein stabilization remains elusive despite extensive research. Amongst various hypotheses, the associated water modulation hypothesis has proven to be the most effective in explaining osmolyte-induced stabilization effects. Earlier we had demonstrated that osmolytes that slow down associated water dynamics enhance protein thermal stability, whereas those that
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A comprehensive engineering strategy improves potency and manufacturability of a near pan-neutralizing antibody against HIV Structure (IF 4.4) Pub Date : 2025-05-14 Mohammad M. Sajadi, Abdolrahim Abbasi, Zahra Rikhtegaran Tehrani, Christine Siska, Rutilio Clark, Woo Chi, Michael S. Seaman, Dieter Mielke, Kshitij Wagh, Qingbo Liu, Taylor Jumpa, Randal R. Ketchem, Dung N. Nguyen, William D. Tolbert, Brian G. Pierce, Ben Atkinson, Derrick Deming, Megan Sprague, Andrew Asakawa, David Ferrer, Anthony DeVico
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Structural insights from active site variants and β-8 loop interactions in viperin-like enzymes Structure (IF 4.4) Pub Date : 2025-05-14 Jake C. Lachowicz, Steven Grudman, Jeffrey B. Bonanno, Andras Fiser, Tyler L. Grove
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STING to the lysosome’s rescue Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2025-05-13 Katarzyna A. Ciazynska
STING (stimulator of interferon genes) functions in innate immunity as an adaptor protein in a signaling cascade initiated upon detection of cytosolic DNA. STING is continuously transported to the lysosome, where it is degraded, to maintain homeostasis after activation, and STING signaling can induce lysosome biogenesis. Lysosome storage disorders (LSDs) can lead to pathogenic STING activation, where
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Visualizing RNA oligomers Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2025-05-13 Katarzyna Marcinkiewicz
The stability and function of many biological macromolecules are regulated by assembling several identical subunits into larger structures. So far, this phenomenon has been best studied in proteins. Now, in a study in Science, Wang et al. use single-particle cryo-electron microscopy (cryo-EM) to visualize several quaternary structures of RNA. The group selected four bacterial noncoding RNA families
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Decoupling chromatin hubs from gene control Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2025-05-13 Darío G. Lupiáñez
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CTCF depletion decouples enhancer-mediated gene activation from chromatin hub formation Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2025-05-13 Magdalena A. Karpinska, Yi Zhu, Zahra Fakhraei Ghazvini, Shyam Ramasamy, Mariano Barbieri, T. B. Ngoc Cao, Natalie Varahram, Abrar Aljahani, Michael Lidschreiber, Argyris Papantonis, A. Marieke Oudelaar
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Mechanistic insight into O=O bond formation upon model-independent visualization of the coordination geometry and ligand composition of Mn4Ca cofactor in dark-adapted photosystem II structures. Acta Cryst. D (IF 2.6) Pub Date : 2025-06-01 Jimin Wang
The Mn4Ca cofactor of photosystem II (PSII), which is found in its oxygen-evolving center (OEC), catalyzes the oxidation of water. Spectroscopic studies performed on dark-adapted PSII samples have led to two mutually incompatible hypotheses about the oxidation states of these manganese ions: Mn(III)4 or Mn(III)2Mn(IV)2. It should be possible to determine which is correct crystallographically because
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The enteric nervous system is 10 times stiffer than the brain. Biophys. J. (IF 3.2) Pub Date : 2025-05-13 Nicolas R Chevalier,Alexis Peaucelle,Thomas Guilbert,Pierre Bourdoncle,Wang Xi
Neural tissues of the central nervous system are among the softest and most fragile in the human body, protected from mechanical perturbation by the skull and the spine. In contrast, the enteric nervous system is embedded in a compliant, contractile tissue and subject to chronic, high-magnitude mechanical stress. Do neurons and glia of the enteric nervous system display specific mechanical properties
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Precision under pressure: The dawn of membrane tension clamping. Biophys. J. (IF 3.2) Pub Date : 2025-05-13 Karan H Muchhala,Arthur Beyder
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Cytoskeletal mechanics in collective cell migration. Biophys. J. (IF 3.2) Pub Date : 2025-05-13 Guang-Kui Xu
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Structural and functional interrelationships of histone H2A with its variants H2A.Z and H2A.W in Arabidopsis Structure (IF 4.4) Pub Date : 2025-05-12 Youchao Wang, Jiabing Wu, Shuoming Yang, Xiang Li, Jiachen Wang, Qinghe Lv, Xiaoyu Zhu, Guoliang Lu, Jinru Zhang, Wen-Hui Shen, Bing Liu, Jinzhong Lin, Aiwu Dong
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Flexing protein assemblies Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2025-05-12 Yang Li, Yang Zhang
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Estrogen Attenuates Stiffness-Driven Fibrotic Signaling via Transcriptional Regulation. Biophys. J. (IF 3.2) Pub Date : 2025-05-12 Hongyuan Zhu,Jin Wang,Yan Liu,Xiaohong Wang,Tian Jian Lu,Feng Xu,Min Lin
Fibrosis, marked by excessive extracellular matrix (ECM) accumulation, underlies functional decline in numerous diseases and often presents with sex-specific differences in severity. While biochemical pathways have been widely studied, the contribution of mechanical cues-particularly ECM stiffness-to these disparities remains unclear. Here, we develop an integrative mechanobiological model to investigate
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Sla2 is a core interaction hub for clathrin light chain and the Pan1/End3/Sla1 complex Structure (IF 4.4) Pub Date : 2025-05-09 George Draper-Barr, Lucas A. Defelipe, David Ruiz-Carrillo, Emil Gustavsson, Meytal Landau, Maria García-Alai
The interaction network of Sla2, a vital endocytic mid-coat adaptor protein, undergoes constant rearrangement. Sla2 serves as a scaffold linking the membrane to the actin cytoskeleton, with its role modulated by the clathrin light chain (CLC), which inhibits Sla2’s function under certain conditions. We show that Sla2 has two independent binding sites for CLC: one previously described in homologs of
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Structural insights into the human system y+L amino acid transporter complex Structure (IF 4.4) Pub Date : 2025-05-09 Lu Dai, Kangtai Xu, Ting Zhang, Xiaoting Wang, Qian Zeng, Hao Liang, Chenye Xu, Liuqing Yang, Zilong Wang, Renhong Yan
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Structural basis of human uromodulin filament networks in uropathogen capture Structure (IF 4.4) Pub Date : 2025-05-08 Andrew N. Chang, Gabriele Cerutti, Yuki Ogawa, Alia Basler, Willa Switzer, Mia Eng-Kohn, Carolyn Lee, Anthony W.P. Fitzpatrick
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Automated atomic force microscopy analysis using convolutional and recurrent neural networks Biophys. J. (IF 3.2) Pub Date : 2025-05-08 Jonathan Haydak, Evren U. Azeloglu
Atomic force microscope (AFM) indentation allows high-resolution spatial characterization of biomechanical properties of cells and tissues. Rapid, reproducible, and quantitative analysis of AFM force curves has been challenging due to several technical limitations, such as excessive noise and uncertainty associated with contact-point determination. Here, we propose a novel machine-learning algorithm
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The mechanism of nesprin-2 accumulation at the nucleus front during confined cell migration Biophys. J. (IF 3.2) Pub Date : 2025-05-08 Inge Bos, Sirine Amiri, Virginie Maire, Thierry Dubois, Alain Karma, Vincent Hakim, Cécile Sykes
Cell migration through constrictions is essential for many physiological processes. During this confined cell migration, the protein nesprin-2, which links the cytoskeletal network to the nucleus, can accumulate at the front of the nucleus. However, up to now, the exact mechanism of this accumulation is unknown. Here, we further investigate this accumulation mechanism. We quantify the spatial distribution
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The YEATS domain is a selective reader of histone methacrylation Structure (IF 4.4) Pub Date : 2025-05-07 Dustin C. Becht, Jiabao Song, Karthik Selvam, Kejun Yin, Weizhi Bai, Yingming Zhao, Ronghu Wu, Y. George Zheng, Tatiana G. Kutateladze
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Deprotonation of retinal Schiff base and structural dynamics in the early photoreaction of primate blue cone visual pigment Biophys. J. (IF 3.2) Pub Date : 2025-05-07 Yosuke Mizuno, Kota Katayama, Hiroo Imai, Hideki Kandori
Animal rhodopsin is a photoreceptive protein crucial for vision, with activation triggered by the cis-trans isomerization of a retinal chromophore upon light absorption. This activation involves a series of thermal intermediates, ultimately leading to G protein-mediated signal transduction. The retinal chromophore is covalently bound to the protein through a protonated Schiff base, and its deprotonation
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Slow awakening of the silent X chromosome in female primordial germ cells Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2025-05-05 Christine M. Disteche, Xinxian Deng
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Chimeric deubiquitinase engineering reveals structural basis for specific inhibition of the mitophagy regulator USP30 Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2025-05-05 Nafizul Haque Kazi, Nikolas Klink, Kai Gallant, Gian-Marvin Kipka, Malte Gersch
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Motor clustering enhances kinesin-driven vesicle transport Biophys. J. (IF 3.2) Pub Date : 2025-05-05 Rui Jiang, Qingzhou Feng, Daguan Nong, You Jung Kang, David Sept, William O. Hancock
Intracellular vesicles are typically transported by a small number of kinesin and dynein motors. However, the slow microtubule binding rate of kinesin-1 observed in in vitro biophysical studies suggests that long-range transport may require a high number of motors. To address the discrepancy in motor requirements between in vivo and in vitro studies, we reconstituted motility of 120-nm-diameter liposomes
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Separation of ionic timescales explains dynamics of cellular volume regulation Biophys. J. (IF 3.2) Pub Date : 2025-05-05 Ram M. Adar
Living cells actively regulate their volume in response to changes in the extracellular environment, such as osmolarity and chemoattractant concentration. While the basic physical mechanisms of volume regulation are understood from the classic “pump-leak” model, it does not provide an explicit expression for the volume during dynamic regulation and can benefit from further insight into the volume dynamics
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Modeling riboswitches: The impact of concentration of Mg2+ ions on the folding of the SAM-II riboswitch Biophys. J. (IF 3.2) Pub Date : 2025-05-05 Osama Alaidi
Riboswitches are regulatory elements present in bacterial messenger RNA acting as sensors of small molecules and consequently playing a vital role in bacterial gene regulation. The SAM-II riboswitch is a class of riboswitches that recognizes S-adenosyl methionine. It has been previously shown that the presence of Mg2+ ions stabilizes the preexisting minor state of the riboswitch, which is structurally
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5′-tRNAHisGUG fragment: A preferred endogenous TLR7 ligand with reverse sequence activation insights Biophys. J. (IF 3.2) Pub Date : 2025-05-05 Kiran Bharat Lokhande, Ashutosh Singh, Rajan Vyas, Shreya Joe, Shailendra Asthana, Kamlesh Pawar
Toll-like receptor 7 (TLR7), a key member of the TLR family, plays a pivotal role in innate immunity, making it an attractive therapeutic target. However, current synthetic TLR7 agonists are often associated with significant toxicity, highlighting the need for safer, naturally occurring alternatives. Our recent research identified 5′-fragments of tRNAHisGUG (5′-HisGUG) and tRNAValCAC/AAC (5′-ValCAC/AAC)
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Cadherin dynamics and cortical tension in remodeling cell-cell adhesion during EMT Biophys. J. (IF 3.2) Pub Date : 2025-05-05 Hongyuan Zhu, Xiaoxi Liu, Jiayu Zhang, Guoqing Zhao, Jin Wang, Huan Zhang, Yan Liu, Hui Guo, Jin Yang, Zheng Wang, Tian Jian Lu, Feng Xu, Min Lin
Epithelial-to-mesenchymal transition (EMT), a key process in cancer metastasis and fibrosis, disrupts cellular adhesion by replacing epithelial E-cadherin with mesenchymal N-cadherin. While, how the shift from E-cadherin to N-cadherin impacts molecular-scale adhesion mechanics and cluster dynamics—and how these changes weaken adhesion under varying mechanical and environmental conditions—remains poorly
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Effect of RNA on the supramolecular architecture of [formula omitted]-synuclein fibrils Biophys. J. (IF 3.2) Pub Date : 2025-05-05 Antonia Intze, Maria Eleonora Temperini, Jakob Rupert, Raffaella Polito, Alexander Veber, Ljiljana Puskar, Ulrich Schade, Michele Ortolani, Elsa Zacco, Gian Gaetano Tartaglia, Valeria Giliberti
Structural changes associated with protein aggregation are challenging to study, requiring the combination of experimental techniques providing insights at the molecular level across diverse scales, ranging from nanometers to microns. Understanding these changes is even more complex when aggregation occurs in the presence of molecular cofactors such as nucleic acids and when the resulting aggregates
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Cardiac action potential generation mechanisms via an intramembrane photoswitch. A simulation study Biophys. J. (IF 3.2) Pub Date : 2025-05-03 Ludovica Cestariolo, Chiara Florindi, Chiara Bertarelli, Antonio Zaza, Guglielmo Lanzani, Francesco Lodola, Jose F. Rodriguez Matas
Optical stimulation is emerging as a promising alternative to conventional methods for both research and therapeutic purposes due to its advantages, such as reduced energy consumption, minimal invasiveness, and exceptional spatial and temporal precision. Recently, we introduced Ziapin2, a novel light-sensitive azobenzene compound, as a tool to modulate cardiac cell excitability and contractility. The
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Asymmetric structure of podophage N4 from the Schitoviridae family reveals a type of tube-sheath short-tail architecture Structure (IF 4.4) Pub Date : 2025-05-02 Jing Zheng, Hao Pang, Hao Xiao, Junquan Zhou, Zhonghua Liu, Wenyuan Chen, Hongrong Liu
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piRNA gene density and SUMOylation organize piRNA transcriptional condensate formation Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2025-05-02 Chengming Zhu, Xiaoyue Si, Xinhao Hou, Panpan Xu, Jianing Gao, Yao Tang, Chenchun Weng, Mingjing Xu, Qi Yan, Qile Jin, Jiewei Cheng, Ke Ruan, Ying Zhou, Ge Shan, Demin Xu, Xiangyang Chen, Shengqi Xiang, Xinya Huang, Xuezhu Feng, Shouhong Guang
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F-actin dynamics regulates collective cell migration by modulating cell shape and stress correlation Biophys. J. (IF 3.2) Pub Date : 2025-05-02 Xiangdong Kong, Zheng Zhong, Chao Fang
As an essential component in generating cell contractility, F-actin plays a pivotal role in collective cell migration. However, the mechanisms by which subcellular F-actin dynamics influence the collective behaviors of cell clusters across scales remain poorly understood. In this study, we developed a mechanical model to investigate how the dynamics of stress fibers and cryptic lamellipodia, prominent
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Introducing Bonnie Murphy, Ville Kaila, Maxie Roessler, Volha Chukhutsina, Alisia Fadini, Sonya Hanson, Filipe Maia, and Kirill Kovalev Structure (IF 4.4) Pub Date : 2025-05-01 Bonnie J. Murphy, Ville R.I. Kaila, Maxie M. Roessler, Volha Chukhutsina, Alisia Fadini, Sonya M. Hanson, Filipe R.N.C. Maia, Kirill Kovalev
In this Voices article, we introduce eight impressive scientists at different career stages who spoke at the recent “8th Ringberg Workshop on Structural Biology (with FELs)” organized by Ilme Schlichting from the Max Planck Institute for Medical Research, Heidelberg. We asked the authors to tell us more about themselves and their exciting research.