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Personalized medicine for cancer cachexia via the ghrelin receptor Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2025-02-14 Meng Zhang, Yaxu Wang, M. Madan Babu
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An in vivo platform to screen for regulators of Huntington’s disease Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2025-02-13 Dimitris Typas
Repeat-expansion diseases, such as Huntington’s disease, often cause detrimental neurodegenerative phenotypes and can be intractable. The onset of Huntington’s disease is dictated by the inherited CAG repeat length and the disease is driven by further somatic repeat expansion in the brain. Although cellular and genome-wide association studies (GWAS) have identified mismatch repair (MMR) genes, and
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FakET: Simulating cryo-electron tomograms with neural style transfer Structure (IF 4.4) Pub Date : 2025-02-12 Pavol Harar, Lukas Herrmann, Philipp Grohs, David Haselbach
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Dynamic integration of feature- and template-based methods improves the prediction of conformational B cell epitopes Structure (IF 4.4) Pub Date : 2025-02-11 Yueyue Shen, Zheng Jiang, Rong Liu
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Unique mechanisms to increase structural stability and enhance antigen binding in nanobodies Structure (IF 4.4) Pub Date : 2025-02-11 Natalia E. Ketaren, Peter C. Fridy, Vladimir Malashkevich, Tanmoy Sanyal, Marc Brillantes, Mary K. Thompson, Deena A. Oren, Jeffrey B. Bonanno, Andrej Šali, Steven C. Almo, Brian T. Chait, Michael P. Rout
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Promoter-proximal RNA polymerase II termination regulates transcription during human cell type transition Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2025-02-11 Kseniia Lysakovskaia, Arjun Devadas, Björn Schwalb, Michael Lidschreiber, Patrick Cramer
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Dynamical Instability is a Major Cause of Cardiac Action Potential Variability. Biophys. J. (IF 3.2) Pub Date : 2025-02-11 Daisuke Sato,Bence Hegyi,Crystal M Ripplinger,Donald M Bers
Increased beat-to-beat QT interval variability (QTV) in the electrocardiogram (ECG) is strongly associated with ventricular arrhythmias and sudden cardiac death, yet its origins remain poorly understood. While heart rate variability (HRV) decreases with deteriorating cardiac health, QTV increases, suggesting distinct underlying mechanisms. The stochastic nature of ion channel gating is a potential
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Selective deuteration of an RNA:RNA complex for structural analysis using small-angle scattering Structure (IF 4.4) Pub Date : 2025-02-10 Aldrex Munsayac, Wellington C. Leite, Jesse B. Hopkins, Ian Hall, Hugh M. O’Neill, Sarah C. Keane
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Uncovering protein glycosylation dynamics and heterogeneity using deep quantitative glycoprofiling (DQGlyco) Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2025-02-10 Clément M. Potel, Mira Lea Burtscher, Martin Garrido-Rodriguez, Amber Brauer-Nikonow, Isabelle Becher, Cecile Le Sueur, Athanasios Typas, Michael Zimmermann, Mikhail M. Savitski
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Initiation of ERAD by the bifunctional complex of Mnl1/Htm1 mannosidase and protein disulfide isomerase Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2025-02-10 Dan Zhao, Xudong Wu, Tom A. Rapoport
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Stochastic Analysis of Human Ovarian Aging and Menopause Timing. Biophys. J. (IF 3.2) Pub Date : 2025-02-10 Anupam Mondal,Evelina Tcherniak,Anatoly B Kolomeisky
Menopause marks a critically important biological event that ends a woman's fertility. It is a result of ovarian aging and depletion of ovarian reserve. While many aspects of these processes are now well understood, the overall dynamic picture remains unclear. Here, we present a novel theoretical framework to analyze human ovarian aging dynamics and menopause timing. Our method is based on stochastic
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Live-Cell Imaging of Single Integrin Tensions with Minimal Background Fluorescence Noise. Biophys. J. (IF 3.2) Pub Date : 2025-02-10 Vivek Pandey,Subhankar Kundu,Arghajit Pyne,Xuefeng Wang
One powerful method for studying cell mechanobiology is to monitor receptor-mediated forces at the single-molecule level in live cells. Hairpin DNA labeled with a quencher-dye pair has been used as a tension probe (TP) to image cellular forces in real time. The TP emits fluorescence when cellular forces unfold the DNA hairpin and de-quench the dye, thereby converting the force signal into fluorescence
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Hyperactive deoxy-PIEZO1 shapes the circulatory lifecycle of irreversibly sickled cells. Biophys. J. (IF 3.2) Pub Date : 2025-02-08 Virgilio L Lew,Simon D Rogers
Sickle cell disease (SCD), affecting millions worldwide, is caused by the homozygous inheritance of the abnormal haemoglobin, HbS. Deoxygenation of HbS in the venous circulation permeabilizes sickle cells to calcium via PIEZO1 channels triggering a dehydration cascade driven by the outward electrochemical potassium gradient. This mechanism operates with particular intensity in a subpopulation of sickle
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Multiple Structural States in an Intrinsically Disordered Protein, SNAP-25, Using Circular Dichroism. Biophys. J. (IF 3.2) Pub Date : 2025-02-08 Jarom S Sumsion,Samuel W Shumway,Tanner M Blocker,Thomas D Weed,Tasha M Chambers,Ryan J Poland,Dixon J Woodbury
SNAP-25, together with other SNARE proteins, drives fusion of synaptic vesicles with the nerve cell membrane leading to neurotransmitter release. It is unique in contributing two α-helices to the four-helix bundle known as the SNARE complex. Complex formation drives fusion as these proteins transform from a disordered-to-ordered (coiled-coil) state. SNAP-25 has two isoforms, -25A and -25B, but little
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The role of peptide conformation presented by MHC in the induction of TCR triggering. Biophys. J. (IF 3.2) Pub Date : 2025-02-07 Andrey V Golovin,Sergey Panteleev,Alexander S Zlobin,Nadia Anikeeva,Ivan Smirnov,Alexander Gabibov,Yuri Sykulev
High resolution crystal structure of stimulatory peptide-MHC (pMHC) ligands bound to TCR revealed different conformation of the two peptides at positions P6 and V7 compared to the conformation of the same peptides presented by unliganded MHC. Supercomputer simulation and well-tempered metadynamics approach revealed several meta-stable non-canonical TCR-pMHC interactions that depend on the conformation
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CryoVIA: An image analysis toolkit for the quantification of membrane structures from cryo-EM micrographs Structure (IF 4.4) Pub Date : 2025-02-06 Philipp Schönnenbeck, Benedikt Junglas, Carsten Sachse
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The mechanosensitive channel YbiO has a conductance equivalent to the largest gated-pore Structure (IF 4.4) Pub Date : 2025-02-06 Benjamin J. Lane, Mariangela Dionysopoulou, Nana Yan, Jonathan D. Lippiat, Stephen P. Muench, Christos Pliotas
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The Anti-TB Structural Center at ShanghaiTech University Structure (IF 4.4) Pub Date : 2025-02-06 Haitao Yang, Lu Zhang, Quan Wang, Jun Li, Xiuna Yang, Yan Gao, Bing Zhang
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Transcription termination—Some like it hot Structure (IF 4.4) Pub Date : 2025-02-06 Kristine Bourke Arnvig, Finn Werner
In this issue of Structure, Dikunova et al.1 report the structure of the trimeric torpedo complex, the key factor responsible for transcription termination by RNA polymerase II R(NAPII) at the end of protein-encoding genes. The comparison between meso- and thermophilic torpedoes provides intriguing insights into thermal adaptions and mechanisms of termination.
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Epithelial sodium channels assemble in an orderly manner: Biology does not play dice Structure (IF 4.4) Pub Date : 2025-02-06 Sarah Pellizzari, Erhu Cao
In this issue of Structure, Houser et al.1 report cryoelectron microscopy (cryo-EM) structures of two atypical forms of the heterotrimeric epithelial sodium channel (ENaC) in which either a δ or a β subunit assembles with one β and one γ subunit. These structures shed light on the molecular principles that govern the assembly of distinct ENaC trimers.
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Illuminating cholesterol-mTORC1 signaling: LYCHOS in focus Structure (IF 4.4) Pub Date : 2025-02-06 Hijai R. Shin, Roberto Zoncu
In a recent issue of Nature, Bayly-Jones et al.1 report the first cryoelectron microscopy (cryo-EM) structure of the lysosomal transmembrane protein LYCHOS, which mediates cholesterol sensing by mTORC1. LYCHOS forms a homodimer, with cholesterol engagement at the transporter-GPCR domain interface, coupled to auxin binding at the transporter-like domain, suggesting multi-domain coordination as critical
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Multiple allosteric mechanisms suppress PRC2 activity at active genes Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2025-02-06 Evan J. Worden
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Enhancing Fluorescence Correlation Spectroscopy with machine learning to infer anomalous molecular motion. Biophys. J. (IF 3.2) Pub Date : 2025-02-06 Nathan Quiblier,Jan-Michael Rye,Pierre Leclerc,Henri Truong,Abdelkrim Hannou,Laurent Heliot,Hugues Berry
The random motion of molecules in living cells has consistently been reported to deviate from standard Brownian motion, a behavior coined as "anomalous diffusion". To study this phenomenon in living cells, Fluorescence Correlation Spectroscopy (FCS) and Single-Particle Tracking (SPT) are the two main methods of reference. In opposition to SPT, FCS with its classical analysis methodology cannot consider
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Structures of a T1-like siphophage reveal capsid stabilization mechanisms and high structural similarities with a myophage Structure (IF 4.4) Pub Date : 2025-02-05 Can Cai, Yueting Wang, Yunshu Liu, Qianqian Shao, Aohan Wang, Lin Li, Yaqi Zheng, Tianyi Zhang, Ziwen Luo, Chongguang Yang, Qianglin Fang
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The structure of a NEMO construct engineered for screening reveals novel determinants of inhibition Structure (IF 4.4) Pub Date : 2025-02-04 Amy E. Kennedy, Adam H. Barczewski, Christina R. Arnoldy, J. Pepper Pennington, Kelly A. Tiernan, M. Beatriz Hidalgo, Caroline C. Reilly, Tanyawan Wongsri, Michael J. Ragusa, Gevorg Grigoryan, Dale F. Mierke, Maria Pellegrini
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Direct effect of membrane environment on the activation of mGluR2 revealed by single-molecule FRET Structure (IF 4.4) Pub Date : 2025-02-04 Chiranjib Banerjee, Brandon Wey-Hung Liauw, Reza Vafabakhsh
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Architecture of an embracing lipase-foldase complex of the type II secretion system of Acinetobacter baumannii Structure (IF 4.4) Pub Date : 2025-02-03 Yuri Rafael de Oliveira Silva, Carlos Contreras-Martel, Ricardo Rodrigues de Melo, Letícia Maria Zanphorlin, Daniel Maragno Trindade, Andréa Dessen
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Structural basis for substrate binding, catalysis and inhibition of cancer target mitochondrial creatine kinase by a covalent inhibitor Structure (IF 4.4) Pub Date : 2025-02-03 Merve Demir, Laura Koepping, Ya Li, Lynn Fujimoto, Andrey Bobkov, Jianhua Zhao, Taro Hitosugi, Eduard Sergienko
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Temperature dependence of membrane viscosity of ternary lipid GUV with Lo domains. Biophys. J. (IF 3.2) Pub Date : 2025-02-03 Julia Tanaka,Kenya Haga,Naohito Urakami,Masayuki Imai,Yuka Sakuma
In the cell membrane, it is considered that saturated lipids and cholesterol organize liquid-ordered (Lo) domains in a sea of liquid-disordered (Ld) phases and proteins relevant to cellular functions are localized in the Lo domains. Since the diffusion of transmembrane proteins is regulated by the membrane viscosity, we investigate the temperature dependence of the membrane viscosity of the ternary
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TomoCPT: a generalizable model for 3D particle detection and localization in cryo-electron tomograms. Acta Cryst. D (IF 2.6) Pub Date : 2025-02-01 Pranav N M Shah,Ruben Sanchez-Garcia,David I Stuart
Cryo-electron tomography is a rapidly developing field for studying macromolecular complexes in their native environments and has the potential to revolutionize our understanding of protein function. However, fast and accurate identification of particles in cryo-tomograms is challenging and represents a significant bottleneck in downstream processes such as subtomogram averaging. Here, we present tomoCPT
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Water occupancy in the Acinetobacter baumannii F-ATP synthase c-ring and its implications as a novel inhibitor target Structure (IF 4.4) Pub Date : 2025-01-31 Alexander Krah, Vandana Grover, Tuck Choy Fong, Peter J. Bond, Gerhard Grüber
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Septin assemblies promote the lipid organization of membranes Structure (IF 4.4) Pub Date : 2025-01-31 Fatima El Alaoui, Isabelle Al-Akiki, Sandy Ibanes, Sébastien Lyonnais, David Sanchez-Fuentes, Rudy Desgarceaux, Chantal Cazevieille, Marie-Pierre Blanchard, Andrea Parmeggiani, Adrian Carretero-Genevrier, Simonetta Piatti, Laura Picas
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Structural basis of circularly permuted group II intron self-splicing Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2025-01-31 Liu Wang, Jiahao Xie, Chong Zhang, Jian Zou, Zirui Huang, Sitong Shang, Xingyu Chen, Yang Yang, Jianquan Liu, Haohao Dong, Dingming Huang, Zhaoming Su
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Transformer graph variational autoencoder for generative molecular design Biophys. J. (IF 3.2) Pub Date : 2025-01-30 Trieu Nguyen, Aleksandra Karolak
In the field of drug discovery, the generation of new molecules with desirable properties remains a critical challenge. Traditional methods often rely on simplified molecular input line entry system representations for molecular input data, which can limit the diversity and novelty of generated molecules. To address this, we present the transformer graph variational autoencoder (TGVAE), an innovative
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Positive Feedback between RyR Phosphorylation and Ca2+ Leak Promotes Heterogeneous Ca2+ Release in Cardiac Myocytes. Biophys. J. (IF 3.2) Pub Date : 2025-01-30 Daisuke Sato,Bardia Ghayoumi,Anna Fasoli,Christopher Y Ko,Donald M Bers
Structural heterogeneity in the distribution of ryanodine receptor (RyR) clusters in cardiac myocytes has been shown to have pro-arrhythmic effects. The presence of a mixture of large and small RyR clusters can potentiate arrhythmogenic calcium (Ca2+) waves. RyRs are subject to post-translational modifications (PTMs), such as phosphorylation, which are linked to heart failure and other pathological
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Growth of nonmotile stress-responsive bacteria in three-dimensional colonies under confining pressure Biophys. J. (IF 3.2) Pub Date : 2025-01-30 Samaneh Rahbar, Farshid Mohammad-Rafiee, Ludger Santen, Reza Shaebani
We numerically study three-dimensional colonies of nonmotile stress-responsive bacteria growing under confining isotropic pressure in a nutrient-rich environment. We develop a novel simulation method to demonstrate how imposing an external pressure leads to a denser aggregate and strengthens the mechanical interactions between bacteria. Unlike rigid confinements that prevent bacterial growth, confining
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Computational design and improvement of a broad influenza virus HA stem targeting antibody Structure (IF 4.4) Pub Date : 2025-01-29 Huarui Duan, Xiaojing Chi, Xuehua Yang, Shengnan Pan, Xiuying Liu, Peixiang Gao, Fangyuan Zhang, Xinhui Zhang, Xuemeng Dong, Yi Liao, Wei Yang
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Structural insights into polyisoprenyl-binding glycosyltransferases Structure (IF 4.4) Pub Date : 2025-01-29 Allen P. Zinkle, Ryan T. Morgan, Rie Nygaard, Filippo Mancia
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Has AlphaFold3 achieved success for RNA? Acta Cryst. D (IF 2.6) Pub Date : 2025-02-01 Clément Bernard,Guillaume Postic,Sahar Ghannay,Fariza Tahi
Predicting the 3D structure of RNA is a significant challenge despite ongoing advancements in the field. Although AlphaFold has successfully addressed this problem for proteins, RNA structure prediction raises difficulties due to the fundamental differences between proteins and RNA, which hinder its direct adaptation. The latest release of AlphaFold, AlphaFold3, has broadened its scope to include multiple
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Structure of a zoonotic H5N1 hemagglutinin reveals a receptor-binding site occupied by an auto-glycan Structure (IF 4.4) Pub Date : 2025-01-29 Nicholas C. Morano, Yicheng Guo, Jordan E. Becker, Zhiteng Li, Jian Yu, David D. Ho, Lawrence Shapiro, Peter D. Kwong
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Physical effects of crowdant size and concentration on collective microtubule polymerization Biophys. J. (IF 3.2) Pub Date : 2025-01-29 Jashaswi Basu, Aman Soni, Chaitanya A. Athale
The polymerization of cytoskeletal filaments is regulated by both biochemical pathways, as well as physical factors such as crowding. The effect of crowding in vivo emerges from the density of intracellular components. Due to the complexity of the intracellular environment, most studies are based on either in vitro reconstitution or theory. Crowding agent (crowdants) size has been shown to influence
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Synaptic cleft geometry modulates NMDAR opening probability by tuning neurotransmitter residence time Biophys. J. (IF 3.2) Pub Date : 2025-01-28 María Hernández Mesa, Kimberly McCabe, Padmini Rangamani
Synaptic morphology plays a critical role in modulating the dynamics of neurotransmitter diffusion and receptor activation in interneuron communication. Central physical aspects of synaptic geometry, such as the curvature of the synaptic cleft, the distance between the presynaptic and postsynaptic membranes, and the surface-area-to-volume ratio of the cleft, crucially influence glutamate diffusion
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Competing addition processes give distinct growth regimes in the assembly of 1D filaments Biophys. J. (IF 3.2) Pub Date : 2025-01-28 Sk Ashif Akram, Tyler Brown, Stephen Whitelam, Georg Meisl, Tuomas P.J. Knowles, Jeremy D. Schmit
We present a model to describe the concentration-dependent growth of protein filaments. Our model contains two states, a low-entropy/high-affinity ordered state and a high-entropy/low-affinity disordered state. Consistent with experiments, our model shows a diffusion-limited linear growth regime at low concentration, followed by a concentration-independent plateau at intermediate concentrations, and
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β-Barrel proteins dictate the effect of core oligosaccharide composition on outer membrane mechanics Biophys. J. (IF 3.2) Pub Date : 2025-01-27 Dylan R. Fitzmaurice, Anthony Amador, Tahj Starr, Glen M. Hocky, Enrique R. Rojas
The outer membrane is the defining structure of Gram-negative bacteria. We previously demonstrated that it is a major load-bearing component of the cell envelope and is therefore critical to the mechanical robustness of the bacterial cell. Here, to determine the key molecules and moieties within the outer membrane that underlie its contribution to cell envelope mechanics, we measured cell-envelope
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NSUN6 inhibitor discovery guided by its mRNA substrate bound crystal structure Structure (IF 4.4) Pub Date : 2025-01-24 Fumei Zhong, Tian Pu, Qian Hu, Mingwei Li, Lei Wang, Suman Wang, Ke Ruan, Yunyu Shi, Beicheng Sun, Yiyang Jiang, Mengqi Lv
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Structural and functional analysis of SAM-dependent N-methyltransferases involved in ovoselenol and ovothiol biosynthesis Structure (IF 4.4) Pub Date : 2025-01-24 Kendra A. Ireland, Chase M. Kayrouz, Marissa L. Abbott, Mohammad R. Seyedsayamdost, Katherine M. Davis
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Structures and mRNP remodeling mechanism of the TREX-2 complex Structure (IF 4.4) Pub Date : 2025-01-24 Yihu Xie, Bradley P. Clarke, Dongqi Xie, Menghan Mei, Prasanna Bhat, Pate S. Hill, Alexia E. Angelos, Tolga Çağatay, Mariam Haider, Scott E. Collier, Melissa G. Chambers, Vasilisa Aksenova, Mary Dasso, Beatriz M.A. Fontoura, Yi Ren
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Cryo-EM structure of the NDH–PSI–LHCI supercomplex from Spinacia oleracea Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2025-01-24 Bianca Introini, Alexander Hahn, Werner Kühlbrandt
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A network of interacting ciliary tip proteins with opposing activities imparts slow and processive microtubule growth Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2025-01-24 Harriet A. J. Saunders, Cyntha M. van den Berg, Robin A. Hoogebeen, Donna Schweizer, Kelly E. Stecker, Ronald Roepman, Stuart C. Howes, Anna Akhmanova
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Reconsideration of the P-clusters in VFe proteins using the bond-valence method: towards their electron transfer and protonation. Acta Cryst. D (IF 2.6) Pub Date : 2025-02-01 Zhen Lang Xie,Wan Ting Jin,Zhao Hui Zhou
P-clusters have been statistically analysed using the bond-valence sum (BVS) method together with weighting schemes. The crystallographic data come from the VFe proteins deposited in the Protein Data Bank (PDB) with high resolutions of better than 1.35 Å. Calculations show that the formal oxidation state of a P1+ cluster can be assigned as 2Fe3+6Fe2+ with high electron delocalization, giving the same
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Quantitative insights into processivity of an Hsp100 protein disaggregase on folded proteins Biophys. J. (IF 3.2) Pub Date : 2025-01-24 Jaskamaljot Kaur Banwait, Aaron L. Lucius
The Hsp100 family of protein disaggregases play important roles in maintaining protein homeostasis in cells. E. coli ClpB is an Hsp100 protein that solubilizes protein aggregates. ClpB is proposed to couple the energy from ATP binding and hydrolysis to processively unfold and translocate protein substrates through its axial channel in the hexameric ring structure. However, many of the details of this
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Adhesion-driven vesicle translocation through membrane-covered pores Biophys. J. (IF 3.2) Pub Date : 2025-01-24 Nishant Baruah, Jiarul Midya, Gerhard Gompper, Anil Kumar Dasanna, Thorsten Auth
Translocation across barriers and through constrictions is a mechanism that is often used in vivo for transporting material between compartments. A specific example is apicomplexan parasites invading host cells through the tight junction that acts as a pore, and a similar barrier crossing is involved in drug delivery using lipid vesicles penetrating intact skin. Here, we use triangulated membranes
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Channel rectification made simple Biophys. J. (IF 3.2) Pub Date : 2025-01-24 Harley T. Kurata, Christopher N. Rowley
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How SNARE proteins generate force to fuse membranes Biophys. J. (IF 3.2) Pub Date : 2025-01-24 Ioana C. Butu, Dong An, Ben O'Shaughnessy
Membrane fusion is central to fundamental cellular processes such as exocytosis, when an intracellular machinery fuses membrane-enclosed vesicles to the plasma membrane for content release. The core machinery components are the SNARE proteins. SNARE complexation pulls the membranes together, but the fusion mechanism remains unclear. A common view is that the complexation energy drives fusion, but how
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Cryo-EM analysis of complement C3 reveals a reversible major opening of the macroglobulin ring Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2025-01-23 Trine Amalie Fogh Gadeberg, Martin Høgholm Jørgensen, Heidi Gytz Olesen, Josefine Lorentzen, Seandean Lykke Harwood, Ana Viana Almeida, Marlene Uglebjerg Fruergaard, Rasmus Kjeldsen Jensen, Philipp Kanis, Henrik Pedersen, Emil Tranchant, Steen Vang Petersen, Ida Buch Thøgersen, Birthe Brandt Kragelund, Joseph Anthony Lyons, Jan Johannes Enghild, Gregers Rom Andersen
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ELL3 regulates spindle assembly to prevent maternally inherited aneuploidy and infertility Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2025-01-22 Bernhard Magerl, Tommaso Cavazza
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The conformational landscape of human transthyretin revealed by cryo-EM Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2025-01-22 Benjamin Basanta, Karina Nugroho, Nicholas L. Yan, Gabriel M. Kline, Evan T. Powers, Felix J. Tsai, Mengyu Wu, Althea Hansel-Harris, Jason S. Chen, Stefano Forli, Jeffrey W. Kelly, Gabriel C. Lander
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Theory of photosynthetic membrane influence on B800-B850 energy transfer in the LH2 complex Biophys. J. (IF 3.2) Pub Date : 2025-01-22 Chawntell Kulkarni, Hallmann Óskar Gestsson, Lorenzo Cupellini, Benedetta Mennucci, Alexandra Olaya-Castro
Photosynthetic organisms rely on a network of light-harvesting protein-pigment complexes to efficiently absorb sunlight and transfer excitation energy to reaction center proteins where charge separation occurs. In photosynthetic purple bacteria, these complexes are embedded within the cell membrane, with lipid composition affecting complex clustering, thereby impacting inter-complex energy transfer
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Temporal and regional X-linked gene reactivation in the mouse germline reveals site-specific retention of epigenetic silencing Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2025-01-21 Clara Roidor, Laurène Syx, Emmanuelle Beyne, Peggy Raynaud, Dina Zielinski, Aurélie Teissandier, Caroline Lee, Marius Walter, Nicolas Servant, Karim Chebli, Deborah Bourc’his, M. Azim Surani, Maud Borensztein
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Botulinum neurotoxins exploit host digestive proteases to boost their oral toxicity via activating OrfXs/P47 Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2025-01-21 Linfeng Gao, Maria Barbara Nowakowska, Katja Selby, Adina Przykopanski, Baohua Chen, Maren Krüger, François Paul Douillard, Kwok-ho Lam, Peng Chen, Ting Huang, Nigel Peter Minton, Martin Bernhard Dorner, Brigitte Gertrud Dorner, Andreas Rummel, Miia Lindström, Rongsheng Jin