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A foundation model for enhancing magnetic resonance images and downstream segmentation, registration and diagnostic tasks Nat. Biomed. Eng. (IF 26.8) Pub Date : 2024-12-05 Yue Sun, Limei Wang, Gang Li, Weili Lin, Li Wang
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In vivo affinity maturation of the CD4 domains of an HIV-1-entry inhibitor Nat. Biomed. Eng. (IF 26.8) Pub Date : 2024-12-05 Andi Pan, Charles C. Bailey, Tianling Ou, Jinge Xu, Tonia Aristotelous, Xin Liu, Baodan Hu, Gogce Crynen, Nickolas Skamangas, Naomi Bronkema, Mai H. Tran, Huihui Mou, Xia Zhang, Michael D. Alpert, Yiming Yin, Michael Farzan, Wenhui He
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A multimodal machine learning model for the stratification of breast cancer risk Nat. Biomed. Eng. (IF 26.8) Pub Date : 2024-12-04 Xuejun Qian, Jing Pei, Chunguang Han, Zhiying Liang, Gaosong Zhang, Na Chen, Weiwei Zheng, Fanlun Meng, Dongsheng Yu, Yixuan Chen, Yiqun Sun, Hanqi Zhang, Wei Qian, Xia Wang, Zhuoran Er, Chenglu Hu, Hui Zheng, Dinggang Shen
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Arrayed CRISPR libraries for the genome-wide activation, deletion and silencing of human protein-coding genes Nat. Biomed. Eng. (IF 26.8) Pub Date : 2024-12-04 Jiang-An Yin, Lukas Frick, Manuel C. Scheidmann, Tingting Liu, Chiara Trevisan, Ashutosh Dhingra, Anna Spinelli, Yancheng Wu, Longping Yao, Dalila Laura Vena, Britta Knapp, Jingjing Guo, Elena De Cecco, Kathi Ging, Andrea Armani, Edward J. Oakeley, Florian Nigsch, Joel Jenzer, Jasmin Haegele, Michal Pikusa, Joachim Täger, Salvador Rodriguez-Nieto, Vangelis Bouris, Rafaela Ribeiro, Federico Baroni,
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Patterned gastrointestinal monolayers with bilateral access as observable models of parasite gut infection Nat. Biomed. Eng. (IF 26.8) Pub Date : 2024-12-04 Moritz Hofer, Maria A. Duque-Correa, Matthias P. Lutolf
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A two-phase point-of-care diagnostic device for bladder cancer Nat. Biomed. Eng. (IF 26.8) Pub Date : 2024-12-02
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Concurrent intratumoural Treg cell depletion and CD8+ T cell expansion via a cleavable anti-4-1BB–interleukin-15 fusion protein Nat. Biomed. Eng. (IF 26.8) Pub Date : 2024-12-02 Yueqi Cai, Zilong Han, Jiao Shen, Zhuangzhi Zou, Jingya Guo, Yong Liang, Shijie Li, Huiping Liao, Zhenhua Ren, Hua Peng, Yang-Xin Fu
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Magnetic-susceptibility-dependent ratiometric probes for enhancing quantitative MRI Nat. Biomed. Eng. (IF 26.8) Pub Date : 2024-11-29 Cheng Zhang, Bin Nan, Juntao Xu, Tengxiang Yang, Li Xu, Chang Lu, Xiao-Bing Zhang, Jianghong Rao, Guosheng Song
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Antibiotic-driven boosting of oncolytic virotherapy Nat. Biomed. Eng. (IF 26.8) Pub Date : 2024-11-28 Himanshu Soni, E. Antonio Chiocca, Joshua D. Bernstock
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Diagnosis of early-stage bladder cancer via unprocessed urine samples at the point of care Nat. Biomed. Eng. (IF 26.8) Pub Date : 2024-11-28 Changjoon Keum, Haejin Yeom, Tae Il Noh, Seung Yong Yi, Soyeong Jin, Chaekyu Kim, Ji Sung Shim, Sung Goo Yoon, Hojun Kim, Kwan Hyi Lee, Seok Ho Kang, Youngdo Jeong
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Safer and efficient base editing and prime editing via ribonucleoproteins delivered through optimized lipid-nanoparticle formulations Nat. Biomed. Eng. (IF 26.8) Pub Date : 2024-11-28 Rafał Hołubowicz, Samuel W. Du, Jiin Felgner, Roman Smidak, Elliot H. Choi, Grazyna Palczewska, Carolline Rodrigues Menezes, Zhiqian Dong, Fangyuan Gao, Omar Medani, Alexander L. Yan, Maria W. Hołubowicz, Paul Z. Chen, Marco Bassetto, Eleonora Risaliti, David Salom, J. Noah Workman, Philip D. Kiser, Andrzej T. Foik, David C. Lyon, Gregory A. Newby, David R. Liu, Philip L. Felgner, Krzysztof Palczewski
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Antibiotic-mediated selection of randomly mutagenized and cytokine-expressing oncolytic viruses Nat. Biomed. Eng. (IF 26.8) Pub Date : 2024-11-28 Reza Rezaei, Stephen Boulton, Mahsa Ahmadi, Julia Petryk, Miles Da Silva, Nika Kooshki Zamani, Ragunath Singaravelu, Gabriel St-Laurent, Lauren Daniel, Arezoo Sadeghipour, Adrian Pelin, Joanna Poutou, Abril Ixchel Munoz Zuniga, Clarence Choy, Victoria H. Gilchrist, Zumama Khalid, Bradley Austin, Kemal Alper Onsu, Ricardo Marius, Zahra Ameli, Fazel Mohammadi, Valeria Mancinelli, Emily Wang, Abolfazl
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Antitumour vaccination via the targeted proteolysis of antigens isolated from tumour lysates Nat. Biomed. Eng. (IF 26.8) Pub Date : 2024-11-28 Yu Zhao, Donghui Song, Zeyu Wang, Qingqing Huang, Fan Huang, Zhongfeng Ye, Douglas Wich, Mengting Chen, Jennifer Khirallah, Shuliang Gao, Yang Liu, Qiaobing Xu
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Optimization of the activity and biodegradability of ionizable lipids for mRNA delivery via directed chemical evolution Nat. Biomed. Eng. (IF 26.8) Pub Date : 2024-11-22 Xuexiang Han, Mohamad-Gabriel Alameh, Ying Xu, Rohan Palanki, Rakan El-Mayta, Garima Dwivedi, Kelsey L. Swingle, Junchao Xu, Ningqiang Gong, Lulu Xue, Qiangqiang Shi, Il-Chul Yoon, Claude C. Warzecha, James M. Wilson, Drew Weissman, Michael J. Mitchell
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Solvent-mediated analgesia via the suppression of water permeation through TRPV1 ion channels Nat. Biomed. Eng. (IF 26.8) Pub Date : 2024-11-21 Yuxia Liu, Yuanyuan He, Jiahuan Tong, Shengyang Guo, Xinyu Zhang, Zichao Luo, Linlin Sun, Chao Chang, Bilin Zhuang, Xiaogang Liu
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Clinical validation of a wearable ultrasound sensor of blood pressure Nat. Biomed. Eng. (IF 26.8) Pub Date : 2024-11-20 Sai Zhou, Geonho Park, Katherine Longardner, Muyang Lin, Baiyan Qi, Xinyi Yang, Xiaoxiang Gao, Hao Huang, Xiangjun Chen, Yizhou Bian, Hongjie Hu, Ray S. Wu, Wentong Yue, Mohan Li, Chengchangfeng Lu, Ruotao Wang, Siyu Qin, Esra Tasali, Theodore Karrison, Isac Thomas, Benjamin Smarr, Erik B. Kistler, Belal Al Khiami, Irene Litvan, Sheng Xu
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Endocytic tagging for degradation Nat. Biomed. Eng. (IF 26.8) Pub Date : 2024-11-19 Filipe V. Almeida
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Ablation of FAS confers allogeneic CD3– CAR T cells with resistance to rejection by T cells and natural killer cells Nat. Biomed. Eng. (IF 26.8) Pub Date : 2024-11-18 Silvia Menegatti, Sheila Lopez-Cobo, Aurelien Sutra Del Galy, Jaime Fuentealba, Lisseth Silva, Laetitia Perrin, Sandrine Heurtebise-Chrétien, Valentine Pottez-Jouatte, Aurelie Darbois, Nina Burgdorf, Anne-Laure Privat, Albane Simon, Marguerite Laprie-Sentenac, Michael Saitakis, Bryce Wick, Beau R. Webber, Branden S. Moriarity, Olivier Lantz, Sebastian Amigorena, Laurie Menger
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Stress impacts immunity via the gut Nat. Biomed. Eng. (IF 26.8) Pub Date : 2024-11-15 Jennifer Haskell
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Dyeing mice transparent Nat. Biomed. Eng. (IF 26.8) Pub Date : 2024-11-15 Alessandra Griffo
A water-soluble dye that absorbs blue light strongly makes it easier to turn mice transparent.
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Endocisternal interfaces for minimally invasive neural stimulation and recording of the brain and spinal cord Nat. Biomed. Eng. (IF 26.8) Pub Date : 2024-11-11 Joshua C. Chen, Abdeali Dhuliyawalla, Robert Garcia, Ariadna Robledo, Joshua E. Woods, Fatima Alrashdan, Sean O’Leary, Adam Husain, Anthony Price, Scott Crosby, Michelle M. Felicella, Ajay K. Wakhloo, Patrick Karas, Nicole Provenza, Wayne Goodman, Sameer A. Sheth, Sunil A. Sheth, Jacob T. Robinson, Peter Kan
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A stealthy neural recorder for the study of behaviour in primates Nat. Biomed. Eng. (IF 26.8) Pub Date : 2024-11-08 Saehyuck Oh, Janghwan Jekal, Jinyoung Won, Kyung Seob Lim, Chang-Yeop Jeon, Junghyung Park, Hyeon-Gu Yeo, Yu Gyeong Kim, Young Hee Lee, Leslie Jaesun Ha, Han Hee Jung, Junwoo Yea, Hyeokjun Lee, Jeongdae Ha, Jinmo Kim, Doyoung Lee, Soojeong Song, Jieun Son, Tae Sang Yu, Jungmin Lee, Sanghoon Lee, Jaehong Lee, Bong Hoon Kim, Ji-Woong Choi, Jong-Cheol Rah, Young Min Song, Jae-Woong Jeong, Hyung Jin Choi
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Large DNA deletions occur during DNA repair at 20-fold lower frequency for base editors and prime editors than for Cas9 nucleases Nat. Biomed. Eng. (IF 26.8) Pub Date : 2024-11-04 Gue-Ho Hwang, Seok-Hoon Lee, Minsik Oh, Segi Kim, Omer Habib, Hyeon-Ki Jang, Heon Seok Kim, Youngkuk Kim, Chan Hyuk Kim, Sun Kim, Sangsu Bae
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Spatially resolved subcellular protein–protein interactomics in drug-perturbed lung-cancer cultures and tissues Nat. Biomed. Eng. (IF 26.8) Pub Date : 2024-10-30 Shuangyi Cai, Thomas Hu, Abhijeet Venkataraman, Felix G. Rivera Moctezuma, Efe Ozturk, Nicholas Zhang, Mingshuang Wang, Tatenda Zvidzai, Sandip Das, Adithya Pillai, Frank Schneider, Suresh S. Ramalingam, You-Take Oh, Shi-Yong Sun, Ahmet F. Coskun
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Ultrabright and ultrafast afterglow imaging in vivo via nanoparticles made of trianthracene derivatives Nat. Biomed. Eng. (IF 26.8) Pub Date : 2024-10-29 Youjuan Wang, Jing Guo, Muchao Chen, Shiyi Liao, Li Xu, Qian Chen, Guosheng Song, Xiao-Bing Zhang
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Expanded toolkits for RNA circularization Nat. Biomed. Eng. (IF 26.8) Pub Date : 2024-10-28 Xiao Wang, Youkui Huang, Ling-Ling Chen
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All-optical optoacoustics for clinical diagnostics Nat. Biomed. Eng. (IF 26.8) Pub Date : 2024-10-25 X. Luís Deán-Ben
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Viscoelastic synthetic antigen-presenting cells for augmenting the potency of cancer therapies Nat. Biomed. Eng. (IF 26.8) Pub Date : 2024-10-25 Zeyang Liu, Yan-Ruide Li, Youcheng Yang, Yu Zhu, Weihao Yuan, Tyler Hoffman, Yifan Wu, Enbo Zhu, Jana Zarubova, Jun Shen, Haochen Nan, Kun-Wei Yeh, Mohammad Mahdi Hasani-Sadrabadi, Yichen Zhu, Ying Fang, Xinyang Ge, Zhizhong Li, Jennifer Soto, Tzung Hsiai, Lili Yang, Song Li
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Computational design of protein binders that boost the antitumour efficacy of CAR T cells Nat. Biomed. Eng. (IF 26.8) Pub Date : 2024-10-24
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Immunogenic amines on lipid nanoparticles Nat. Biomed. Eng. (IF 26.8) Pub Date : 2024-10-23 Preeti Sharma, Dor Breier, Dan Peer
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Downregulating human leucocyte antigens on mesenchymal stromal cells by epigenetically repressing a β2-microglobulin super-enhancer Nat. Biomed. Eng. (IF 26.8) Pub Date : 2024-10-21 Fei Wang, Ran Li, Jing Yi Xu, Xiaoxia Bai, Ying Wang, Xu Ri Chen, Chen Pan, Shen Chen, Ke Zhou, Boon Chin Heng, Xuewei Wu, Wei Guo, Zhe Song, Shu Cheng Jin, Jing Zhou, Xiao Hui Zou, Hong Wei Ouyang, Hua Liu
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Targeting overexpressed antigens in glioblastoma via CAR T cells with computationally designed high-affinity protein binders Nat. Biomed. Eng. (IF 26.8) Pub Date : 2024-10-17 Zhen Xia, Qihan Jin, Zhilin Long, Yexuan He, Fuyi Liu, Chengfang Sun, Jinyang Liao, Chun Wang, Chentong Wang, Jian Zheng, Weixi Zhao, Tianxin Zhang, Jeremy N. Rich, Yongdeng Zhang, Longxing Cao, Qi Xie
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Systemically injected oxygen within rapidly dissolving microbubbles improves the outcomes of severe hypoxaemia in swine Nat. Biomed. Eng. (IF 26.8) Pub Date : 2024-10-17 Julia Garcia Mancebo, Kristen Sack, Jay Hartford, Saffron Dominguez, Michelle Balcarcel-Monzon, Elizabeth Chartier, Tien Nguyen, Alexis R. Cole, Francesca Sperotto, David M. Harrild, Brian D. Polizzotti, Allen D. Everett, Alan B. Packard, Jason Dearling, Arthur G. Nedder, Simon Warfield, Edward Yang, Hart G. W. Lidov, John N. Kheir, Yifeng Peng
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Interpretable discovery of patterns in tabular data via spatially semantic topographic maps Nat. Biomed. Eng. (IF 26.8) Pub Date : 2024-10-15 Rui Yan, Md Tauhidual Islam, Lei Xing
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Synthetic chest X-ray images from text prompts Nat. Biomed. Eng. (IF 26.8) Pub Date : 2024-10-07 Daniel Truhn, Jakob Nikolas Kather
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Immunometabolic cues recompose and reprogram the microenvironment around implanted biomaterials Nat. Biomed. Eng. (IF 26.8) Pub Date : 2024-10-04 Chima V. Maduka, Axel D. Schmitter-Sánchez, Ashley V. Makela, Evran Ural, Katlin B. Stivers, Hunter Pope, Maxwell M. Kuhnert, Oluwatosin M. Habeeb, Anthony Tundo, Mohammed Alhaj, Artem Kiselev, Shoue Chen, Alexis Donneys, Wade P. Winton, Jenelle Stauff, Peter J. H. Scott, Andrew J. Olive, Kurt D. Hankenson, Ramani Narayan, Sangbum Park, Jennifer H. Elisseeff, Christopher H. Contag
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Amine headgroups in ionizable lipids drive immune responses to lipid nanoparticles by binding to the receptors TLR4 and CD1d Nat. Biomed. Eng. (IF 26.8) Pub Date : 2024-10-03 Namit Chaudhary, Lisa N. Kasiewicz, Alexandra N. Newby, Mariah L. Arral, Saigopalakrishna S. Yerneni, Jilian R. Melamed, Samuel T. LoPresti, Katherine C. Fein, Daria M. Strelkova Petersen, Sushant Kumar, Rahul Purwar, Kathryn A. Whitehead
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Accurate prediction of disease-risk factors from volumetric medical scans by a deep vision model pre-trained with 2D scans Nat. Biomed. Eng. (IF 26.8) Pub Date : 2024-10-01 Oren Avram, Berkin Durmus, Nadav Rakocz, Giulia Corradetti, Ulzee An, Muneeswar G. Nittala, Prerit Terway, Akos Rudas, Zeyuan Johnson Chen, Yu Wakatsuki, Kazutaka Hirabayashi, Swetha Velaga, Liran Tiosano, Federico Corvi, Aditya Verma, Ayesha Karamat, Sophiana Lindenberg, Deniz Oncel, Louay Almidani, Victoria Hull, Sohaib Fasih-Ahmad, Houri Esmaeilkhanian, Maxime Cannesson, Charles C. Wykoff, Elior
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A fast all-optical 3D photoacoustic scanner for clinical vascular imaging Nat. Biomed. Eng. (IF 26.8) Pub Date : 2024-09-30 N. T. Huynh, E. Zhang, O. Francies, F. Kuklis, T. Allen, J. Zhu, O. Abeyakoon, F. Lucka, M. Betcke, J. Jaros, S. Arridge, B. Cox, A. A. Plumb, P. Beard
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Engineered allogeneic T cells decoupling T-cell-receptor and CD3 signalling enhance the antitumour activity of bispecific antibodies Nat. Biomed. Eng. (IF 26.8) Pub Date : 2024-09-25 Edo Kapetanovic, Cédric R. Weber, Marine Bruand, Daniel Pöschl, Jakub Kucharczyk, Elisabeth Hirth, Claudius Dietsche, Riyaz Khan, Bastian Wagner, Olivier Belli, Rodrigo Vazquez-Lombardi, Rocío Castellanos- Rueda, Raphael B. Di Roberto, Kevin Kalinka, Luca Raess, Kevin Ly, Shivam Rai, Petra S. Dittrich, Randall J. Platt, Elisa Oricchio, Sai T. Reddy
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Meta-analysis of the make-up and properties of in vitro models of the healthy and diseased blood–brain barrier Nat. Biomed. Eng. (IF 26.8) Pub Date : 2024-09-20 James G. Shamul, Zhiyuan Wang, Hyeyeon Gong, Wenquan Ou, Alisa M. White, Diogo P. Moniz-Garcia, Shuo Gu, Alisa Morss Clyne, Alfredo Quiñones-Hinojosa, Xiaoming He
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Non-viral targeted insertion of large payloads into T cells Nat. Biomed. Eng. (IF 26.8) Pub Date : 2024-09-16 Zsuzsanna Izsvák
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Learning what keeps nanomedicines in tumours Nat. Biomed. Eng. (IF 26.8) Pub Date : 2024-09-13 Yifan Wang, Benjamin R. Schrank, Wen Jiang, Betty Y. S. Kim
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In situ formation of biomolecular condensates as intracellular drug reservoirs for augmenting chemotherapy Nat. Biomed. Eng. (IF 26.8) Pub Date : 2024-09-13 Tingxizi Liang, Yuxiang Dong, Irina Cheng, Ping Wen, Fengqin Li, Feng Liu, Qing Wu, En Ren, Peifeng Liu, Hongjun Li, Zhen Gu
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A pan-cancer dye for solid-tumour screening, resection and wound monitoring via short-wave and near-infrared fluorescence imaging Nat. Biomed. Eng. (IF 26.8) Pub Date : 2024-09-09 Benedict Edward Mc Larney, Ali Yasin Sonay, Elana Apfelbaum, Nermin Mostafa, Sébastien Monette, Dana Goerzen, Nicole Aguirre, Rüdiger M. Exner, Christine Habjan, Elizabeth Isaac, Ngan Bao Phung, Magdalena Skubal, Mijin Kim, Anuja Ogirala, Darren Veach, Daniel A. Heller, Jan Grimm
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Virally delivered CMYA5 enhances the assembly of cardiac dyads Nat. Biomed. Eng. (IF 26.8) Pub Date : 2024-09-05 Fujian Lu, Carter Liou, Qing Ma, Zexuan Wu, Bingqing Xue, Yu Xia, Shutao Xia, Michael A. Trembley, Anna Ponek, Wenjun Xie, Kevin Shani, Raul H. Bortolin, Maksymilian Prondzynski, Paul Berkson, Xiaoran Zhang, Francisco J. Naya, Kenneth C. Bedi, Kenneth B. Margulies, Donghui Zhang, Kevin K. Parker, William T. Pu
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Engineering signalling pathways in mammalian cells Nat. Biomed. Eng. (IF 26.8) Pub Date : 2024-09-05 Anna V. Leopold, Vladislav V. Verkhusha
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Low-cost and scalable projected light-sheet microscopy for the high-resolution imaging of cleared tissue and living samples Nat. Biomed. Eng. (IF 26.8) Pub Date : 2024-08-29 Yannan Chen, Shradha Chauhan, Cheng Gong, Hannah Dayton, Cong Xu, Estanislao Daniel De La Cruz, Yu-Young Wesley Tsai, Malika S. Datta, Gorazd B. Rosoklija, Andrew J. Dwork, J. John Mann, Maura Boldrini, Kam W. Leong, Lars E. P. Dietrich, Raju Tomer
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A vision–language foundation model for the generation of realistic chest X-ray images Nat. Biomed. Eng. (IF 26.8) Pub Date : 2024-08-26 Christian Bluethgen, Pierre Chambon, Jean-Benoit Delbrouck, Rogier van der Sluijs, Małgorzata Połacin, Juan Manuel Zambrano Chaves, Tanishq Mathew Abraham, Shivanshu Purohit, Curtis P. Langlotz, Akshay S. Chaudhari
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Robust genome and cell engineering via in vitro and in situ circularized RNAs Nat. Biomed. Eng. (IF 26.8) Pub Date : 2024-08-26 Michael Tong, Nathan Palmer, Amir Dailamy, Aditya Kumar, Hammza Khaliq, Sangwoo Han, Emma Finburgh, Madeleine Wing, Camilla Hong, Yichen Xiang, Katelyn Miyasaki, Andrew Portell, Joseph Rainaldi, Amanda Suhardjo, Sami Nourreddine, Wei Leong Chew, Ester J. Kwon, Prashant Mali
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Standardizing designed and emergent quantitative features in microphysiological systems Nat. Biomed. Eng. (IF 26.8) Pub Date : 2024-08-26 Dennis M. Nahon, Renée Moerkens, Hande Aydogmus, Bas Lendemeijer, Adriana Martínez-Silgado, Jeroen M. Stein, Milica Dostanić, Jean-Philippe Frimat, Cristina Gontan, Mees N. S. de Graaf, Michel Hu, Dhanesh G. Kasi, Lena S. Koch, Kieu T. T. Le, Sangho Lim, Heleen H. T. Middelkamp, Joram Mooiweer, Paul Motreuil-Ragot, Eva Niggl, Cayetano Pleguezuelos-Manzano, Jens Puschhof, Nele Revyn, José M. Rivera-Arbelaez
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The formation and maintenance of peri-implant fibrosis requires skeletal cells expressing the leptin receptor Nat. Biomed. Eng. (IF 26.8) Pub Date : 2024-08-14
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A base editor for correcting deafness Nat. Biomed. Eng. (IF 26.8) Pub Date : 2024-08-12 Bence György
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A base editor for the long-term restoration of auditory function in mice with recessive profound deafness Nat. Biomed. Eng. (IF 26.8) Pub Date : 2024-08-12 Chong Cui, Shengyi Wang, Daqi Wang, Jingjing Zhao, Bowei Huang, Biyun Zhu, Yuxin Chen, Honghai Tang, Yu Han, Cheng Ye, Dan Mu, Chengdong Zhang, Yuan Yang, Yihan Bao, Jun Lv, Shuang Han, Geng-Lin Li, Huawei Li, Yilai Shu
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Contributions of network structure, chemoarchitecture and diagnostic categories to transitions between cognitive topographies Nat. Biomed. Eng. (IF 26.8) Pub Date : 2024-08-05 Andrea I. Luppi, S. Parker Singleton, Justine Y. Hansen, Keith W. Jamison, Danilo Bzdok, Amy Kuceyeski, Richard F. Betzel, Bratislav Misic
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PEGylated bacteria penetrate mucus and strengthen the gut mucosal barrier Nat. Biomed. Eng. (IF 26.8) Pub Date : 2024-08-01
更新日期：2024-11-08
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