当前期刊: Science Advances Go to current issue    加入关注   
显示样式:        排序: IF: - GO 导出
我的关注
我的收藏
您暂时未登录!
登录
  • Reevaluating the evidence for a Hadean-Eoarchean dynamo
    Sci. Adv. (IF 12.804) Pub Date : 2020-04-08
    Cauê S. Borlina, Benjamin P. Weiss, Eduardo A. Lima, Fengzai Tang, Richard J. M. Taylor, Joshua F. Einsle, Richard J. Harrison, Roger R. Fu, Elizabeth A. Bell, Ellen W. Alexander, Heather M. Kirkpatrick, Matthew M. Wielicki, T. Mark Harrison, Jahandar Ramezani, Adam C. Maloof

    The time of origin of the geodynamo has important implications for the thermal evolution of the planetary interior and the habitability of early Earth. It has been proposed that detrital zircon grains from Jack Hills, Western Australia, provide evidence for an active geodynamo as early as 4.2 billion years (Ga) ago. However, our combined paleomagnetic, geochemical, and mineralogical studies on Jack

    更新日期:2020-04-08
  • Soft extracellular matrix enhances inflammatory activation of mesenchymal stromal cells to induce monocyte production and trafficking
    Sci. Adv. (IF 12.804) Pub Date : 2020-04-08
    Sing Wan Wong, Stephen Lenzini, Madeline H. Cooper, David J. Mooney, Jae-Won Shin

    Mesenchymal stromal cells (MSCs) modulate immune cells to ameliorate multiple inflammatory pathologies. Biophysical signals that regulate this process are poorly defined. By engineering hydrogels with tunable biophysical parameters relevant to bone marrow where MSCs naturally reside, we show that soft extracellular matrix maximizes the ability of MSCs to produce paracrine factors that have been implicated

    更新日期:2020-04-08
  • Targeting the scaffolding role of LSD1 (KDM1A) poises acute myeloid leukemia cells for retinoic acid–induced differentiation
    Sci. Adv. (IF 12.804) Pub Date : 2020-04-08
    Roberto Ravasio, Elena Ceccacci, Luciano Nicosia, Amir Hosseini, Pier Luigi Rossi, Iros Barozzi, Lorenzo Fornasari, Roberto Dal Zuffo, Sergio Valente, Rossella Fioravanti, Ciro Mercurio, Mario Varasi, Andrea Mattevi, Antonello Mai, Giulio Pavesi, Tiziana Bonaldi, Saverio Minucci

    The histone demethylase LSD1 is deregulated in several tumors, including leukemias, providing the rationale for the clinical use of LSD1 inhibitors. In acute promyelocytic leukemia (APL), pharmacological doses of retinoic acid (RA) induce differentiation of APL cells, triggering degradation of the PML-RAR oncogene. APL cells are resistant to LSD1 inhibition or knockout, but targeting LSD1 sensitizes

    更新日期:2020-04-08
  • The cohesin release factor Wapl interacts with Bub3 to govern SAC activity in female meiosis I
    Sci. Adv. (IF 12.804) Pub Date : 2020-04-08
    Changyin Zhou, Yilong Miao, Zhaokang Cui, Xiayan ShiYang, Yu Zhang, Bo Xiong

    During mitotic prophase, cohesins are removed from chromosome arms by Wapl to ensure faithful sister chromatid separation. However, during female meiosis I, the resolution of chiasmata requires the proteolytic cleavage of cohesin subunit Rec8 along chromosome arms by Separase to separate homologs, and thus the role of Wapl remained unknown. Here, we report that Wapl functions as a regulator of spindle

    更新日期:2020-04-08
  • Synaptic silencing of fast muscle is compensated by rewired innervation of slow muscle
    Sci. Adv. (IF 12.804) Pub Date : 2020-04-08
    Buntaro Zempo, Yasuhiro Yamamoto, Tory Williams, Fumihito Ono

    For decades, numerous studies have proposed that fast muscles contribute to quick movement, while slow muscles underlie locomotion requiring endurance. By generating mutant zebrafish whose fast muscles are synaptically silenced, we examined the contribution of fast muscles in both larval and adult zebrafish. In the larval stage, mutants lacked the characteristic startle response to tactile stimuli:

    更新日期:2020-04-08
  • Regeneration of pulpo-dentinal–like complex by a group of unique multipotent CD24a+ stem cells
    Sci. Adv. (IF 12.804) Pub Date : 2020-04-08
    Hong Chen, Huancheng Fu, Xue Wu, Yufeng Duan, Sicheng Zhang, Hong Hu, Yuansong Liao, Tao Wang, Yan Yang, Guoqing Chen, Zhonghan Li, Weidong Tian

    Dental pulp is critical to maintain the vitality of a tooth. Regeneration of pulpo-dentinal complex is of great interest to treat pulpitis and pulp necrosis. In this study, through three-dimensional spheroid culture, a group of unique multipotent stem cells were identified from mouse dental papilla called multipotent dental pulp regenerative stem cells (MDPSCs). MDPSCs exhibited enhanced osteogenic/odontogenic

    更新日期:2020-04-08
  • Picoscale structural insight into superconductivity of monolayer FeSe/SrTiO3
    Sci. Adv. (IF 12.804) Pub Date : 2020-04-08
    Rui Peng, Ke Zou, M. G. Han, Stephen D. Albright, Hawoong Hong, Claudia Lau, H. C. Xu, Yimei Zhu, F. J. Walker, C. H. Ahn

    Remarkable enhancement of the superconducting transition temperature (Tc) has been observed for monolayer (ML) FeSe films grown on SrTiO3 substrates. The atomic-scale structure of the FeSe/SrTiO3 interface is an important determinant of both the magnetic and interfacial electron-phonon interactions and is a key ingredient to understanding its high-Tc superconductivity. We resolve the atomic-scale structure

    更新日期:2020-04-08
  • Online education platforms scale college STEM instruction with equivalent learning outcomes at lower cost
    Sci. Adv. (IF 12.804) Pub Date : 2020-04-08
    Igor Chirikov, Tatiana Semenova, Natalia Maloshonok, Eric Bettinger, René F. Kizilcec

    Meeting global demand for growing the science, technology, engineering, and mathematics (STEM) workforce requires solutions for the shortage of qualified instructors. We propose and evaluate a model for scaling up affordable access to effective STEM education through national online education platforms. These platforms allow resource-constrained higher education institutions to adopt online courses

    更新日期:2020-04-08
  • Metabolic maturation in the first 2 years of life in resource-constrained settings and its association with postnatal growths
    Sci. Adv. (IF 12.804) Pub Date : 2020-04-08
    N. Giallourou, F. Fardus-Reid, G. Panic, K. Veselkov, B. J. J. McCormick, M. P. Olortegui, T. Ahmed, E. Mduma, P. P. Yori, M. Mahfuz, E. Svensen, M. M. M. Ahmed, J. M. Colston, M. N. Kosek, J. R. Swann

    Malnutrition continues to affect the growth and development of millions of children worldwide, and chronic undernutrition has proven to be largely refractory to interventions. Improved understanding of metabolic development in infancy and how it differs in growth-constrained children may provide insights to inform more timely, targeted, and effective interventions. Here, the metabolome of healthy infants

    更新日期:2020-04-08
  • Eradication of tumor growth by delivering novel photothermal selenium-coated tellurium nanoheterojunctions
    Sci. Adv. (IF 12.804) Pub Date : 2020-04-08
    Shiyou Chen, Chenyang Xing, Dazhou Huang, Chuanhong Zhou, Bo Ding, Ziheng Guo, Zhengchun Peng, Dou Wang, Xi Zhu, Shuzhen Liu, Zhen Cai, Jieyu Wu, Jiaqi Zhao, Zongze Wu, Yuhua Zhang, Chaoying Wei, Qiaoting Yan, Hongzhong Wang, Dianyuan Fan, Liping Liu, Han Zhang, Yihai Cao

    Two-dimensional nanomaterial-based photothermal therapy (PTT) is currently under intensive investigation as a promising approach toward curative cancer treatment. However, high toxicity, moderate efficacy, and low uniformity in shape remain critical unresolved issues that hamper their clinical application. Thus, there is an urgent need for developing versatile nanomaterials to meet clinical expectations

    更新日期:2020-04-08
  • Procedural fairness and nepotism among local traditional and democratic leaders in rural Namibia
    Sci. Adv. (IF 12.804) Pub Date : 2020-04-08
    Björn Vollan, Esther Blanco, Ivo Steimanis, Fabian Petutschnig, Sebastian Prediger

    This study tests the common conception that democratically elected leaders behave in the interest of their constituents more than traditional chiefs do. Our sample includes 64 village leaders and 384 villagers in rural Namibia, where democratically elected leaders and traditional chiefs coexist. We analyze two main attributes of local political leaders: procedural fairness preferences and preferential

    更新日期:2020-04-08
  • Mechanism of actin N-terminal acetylation
    Sci. Adv. (IF 12.804) Pub Date : 2020-04-08
    Grzegorz Rebowski, Malgorzata Boczkowska, Adrian Drazic, Rasmus Ree, Marianne Goris, Thomas Arnesen, Roberto Dominguez

    About 80% of human proteins are amino-terminally acetylated (Nt-acetylated) by one of seven Nt-acetyltransferases (NATs). Actin, the most abundant protein in the cytoplasm, has its own dedicated NAT, NAA80, which acts posttranslationally and affects cytoskeleton assembly and cell motility. Here, we show that NAA80 does not associate with filamentous actin in cells, and its natural substrate is the

    更新日期:2020-04-08
  • Improving the efficiency of precise genome editing with site-specific Cas9-oligonucleotide conjugates
    Sci. Adv. (IF 12.804) Pub Date : 2020-04-08
    Xinyu Ling, Bingteng Xie, Xiaoqin Gao, Liying Chang, Wei Zheng, Heqi Chen, Yujia Huang, Linzhi Tan, Mo Li, Tao Liu

    Site-specific chemical conjugation of proteins can enhance their therapeutic and diagnostic utility but has seldom been applied to CRISPR-Cas9, which is a rapidly growing field with great therapeutic potential. The low efficiency of homology-directed repair remains a major hurdle in CRISPR-Cas9–mediated precise genome editing, which is limited by low concentration of donor DNA template at the cleavage

    更新日期:2020-04-08
  • The pharyngeal nervous system orchestrates feeding behavior in planarians
    Sci. Adv. (IF 12.804) Pub Date : 2020-04-08
    Mai Miyamoto, Miki Hattori, Kazutaka Hosoda, Mika Sawamoto, Minako Motoishi, Tetsutaro Hayashi, Takeshi Inoue, Yoshihiko Umesono

    Planarians exhibit traits of cephalization but are unique among bilaterians in that they ingest food by means of goal-directed movements of a trunk-positioned pharynx, following protrusion of the pharynx out of the body, raising the question of how planarians control such a complex set of body movements for achieving robust feeding. Here, we use the freshwater planarian Dugesia japonica to show that

    更新日期:2020-04-08
  • The Mgs1/WRNIP1 ATPase is required to prevent a recombination salvage pathway at damaged replication forks
    Sci. Adv. (IF 12.804) Pub Date : 2020-04-08
    Alberto Jiménez-Martín, Irene Saugar, Chinnu Rose Joseph, Alexandra Mayer, Carl P. Lehmann, Barnabas Szakal, Dana Branzei, José Antonio Tercero

    DNA damage tolerance (DDT) is crucial for genome integrity maintenance. DDT is mainly carried out by template switch recombination, an error-free mode of overcoming DNA lesions, or translesion DNA synthesis, which is error-prone. Here, we investigated the role of Mgs1/WRNIP1 in modulating DDT. Using budding yeast, we found that elimination of Mgs1 in cells lacking Rad5, an essential protein for DDT

    更新日期:2020-04-08
  • Locus coeruleus norepinephrine activity mediates sensory-evoked awakenings from sleep
    Sci. Adv. (IF 12.804) Pub Date : 2020-04-08
    Hanna Hayat, Noa Regev, Noa Matosevich, Anna Sales, Elena Paredes-Rodriguez, Aaron J. Krom, Lottem Bergman, Yong Li, Marina Lavigne, Eric J. Kremer, Ofer Yizhar, Anthony E. Pickering, Yuval Nir

    A defining feature of sleep is reduced responsiveness to external stimuli, but the mechanisms mediating sensory-evoked arousal remain unclear. We hypothesized that reduced locus coeruleus (LC) norepinephrine (NE) activity during sleep mediates unresponsiveness, and its action promotes sensory-evoked awakenings. We tested this using electrophysiological, behavioral, pharmacological, and optogenetic

    更新日期:2020-04-08
  • Force production of human cytoplasmic dynein is limited by its processivity
    Sci. Adv. (IF 12.804) Pub Date : 2020-04-08
    Sibylle Brenner, Florian Berger, Lu Rao, Matthew P. Nicholas, Arne Gennerich

    Cytoplasmic dynein is a highly complex motor protein that generates forces toward the minus end of microtubules. Using optical tweezers, we demonstrate that the low processivity (ability to take multiple steps before dissociating) of human dynein limits its force generation due to premature microtubule dissociation. Using a high trap stiffness whereby the motor achieves greater force per step, we reveal

    更新日期:2020-04-08
  • Complete aggregation pathway of amyloid β (1-40) and (1-42) resolved on an atomically clean interface
    Sci. Adv. (IF 12.804) Pub Date : 2020-04-08
    Peter Niraj Nirmalraj, Jonathan List, Shayon Battacharya, Geoffrey Howe, Liang Xu, Damien Thompson, Michael Mayer

    To visualize amyloid β (Aβ) aggregates requires an uncontaminated and artifact-free interface. This paper demonstrates the interface between graphene and pure water (verified to be atomically clean using tunneling microscopy) as an ideal platform for resolving size, shape, and morphology (measured by atomic force microscopy) of Aβ-40 and Aβ-42 peptide assemblies from 0.5 to 150 hours at a 5-hour time

    更新日期:2020-04-08
  • Exosome-based delivery of super-repressor IκBα relieves sepsis-associated organ damage and mortality
    Sci. Adv. (IF 12.804) Pub Date : 2020-04-08
    Hojun Choi, Youngeun Kim, Amin Mirzaaghasi, Jaenyoung Heo, Yu Na Kim, Ju Hye Shin, Seonghun Kim, Nam Hee Kim, Eunae Sandra Cho, Jong In Yook, Tae-Hyun Yoo, Eunjoo Song, Pilhan Kim, Eui-Cheol Shin, Kyungsoo Chung, Kyungsun Choi, Chulhee Choi

    As extracellular vesicles that play an active role in intercellular communication by transferring cellular materials to recipient cells, exosomes offer great potential as a natural therapeutic drug delivery vehicle. The inflammatory responses in various disease models can be attenuated through introduction of super-repressor IκB (srIκB), which is the dominant active form of IκBα and can inhibit translocation

    更新日期:2020-04-08
  • Climate models miss most of the coarse dust in the atmosphere
    Sci. Adv. (IF 12.804) Pub Date : 2020-04-08
    Adeyemi A. Adebiyi, Jasper F. Kok

    Coarse mineral dust (diameter, ≥5 μm) is an important component of the Earth system that affects clouds, ocean ecosystems, and climate. Despite their significance, climate models consistently underestimate the amount of coarse dust in the atmosphere when compared to measurements. Here, we estimate the global load of coarse dust using a framework that leverages dozens of measurements of atmospheric

    更新日期:2020-04-08
  • Cooperativity of Kv7.4 channels confers ultrafast electromechanical sensitivity and emergent properties in cochlear outer hair cells
    Sci. Adv. (IF 12.804) Pub Date : 2020-04-08
    Maria C. Perez-Flores, Jeong H. Lee, Seojin Park, Xiao-Dong Zhang, Choong-Ryoul Sihn, Hannah A. Ledford, Wenying Wang, Hyo Jeong Kim, Valeriy Timofeyev, Vladimir Yarov-Yarovoy, Nipavan Chiamvimonvat, Richard D. Rabbitt, Ebenezer N. Yamoah

    The mammalian cochlea relies on active electromotility of outer hair cells (OHCs) to resolve sound frequencies. OHCs use ionic channels and somatic electromotility to achieve the process. It is unclear, though, how the kinetics of voltage-gated ionic channels operate to overcome extrinsic viscous drag on OHCs at high frequency. Here, we report ultrafast electromechanical gating of clustered Kv7.4 in

    更新日期:2020-04-08
  • The hypertrophic cardiomyopathy mutations R403Q and R663H increase the number of myosin heads available to interact with actin
    Sci. Adv. (IF 12.804) Pub Date : 2020-04-03
    Saswata S. Sarkar, Darshan V. Trivedi, Makenna M. Morck, Arjun S. Adhikari, Shaik N. Pasha, Kathleen M. Ruppel, James A. Spudich

    Hypertrophic cardiomyopathy (HCM) mutations in β-cardiac myosin and myosin binding protein-C (MyBP-C) lead to hypercontractility of the heart, an early hallmark of HCM. We show that hypercontractility caused by the HCM-causing mutation R663H cannot be explained by changes in fundamental myosin contractile parameters, much like the HCM-causing mutation R403Q. Using enzymatic assays with purified human

    更新日期:2020-04-06
  • Evaluating the fake news problem at the scale of the information ecosystem
    Sci. Adv. (IF 12.804) Pub Date : 2020-04-03
    Jennifer Allen, Baird Howland, Markus Mobius, David Rothschild, Duncan J. Watts

    “Fake news,” broadly defined as false or misleading information masquerading as legitimate news, is frequently asserted to be pervasive online with serious consequences for democracy. Using a unique multimode dataset that comprises a nationally representative sample of mobile, desktop, and television consumption, we refute this conventional wisdom on three levels. First, news consumption of any sort

    更新日期:2020-04-06
  • Quantum computation solves a half-century-old enigma: Elusive vibrational states of magnesium dimer found
    Sci. Adv. (IF 12.804) Pub Date : 2020-04-03
    Stephen H. Yuwono, Ilias Magoulas, Piotr Piecuch

    The high-lying vibrational states of the magnesium dimer (Mg2), which has been recognized as an important system in studies of ultracold and collisional phenomena, have eluded experimental characterization for half a century. Until now, only the first 14 vibrational states of Mg2 have been experimentally resolved, although it has been suggested that the ground-state potential may support five additional

    更新日期:2020-04-06
  • Direct observation of minibands in a twisted graphene/WS2 bilayer
    Sci. Adv. (IF 12.804) Pub Date : 2020-04-03
    Søren Ulstrup, Roland J. Koch, Simranjeet Singh, Kathleen M. McCreary, Berend T. Jonker, Jeremy T. Robinson, Chris Jozwiak, Eli Rotenberg, Aaron Bostwick, Jyoti Katoch, Jill A. Miwa

    Stacking two-dimensional (2D) van der Waals materials with different interlayer atomic registry in a heterobilayer causes the formation of a long-range periodic superlattice that may bestow the heterostructure with properties such as new quantum fractal states or superconductivity. Recent optical measurements of transition metal dichalcogenide (TMD) heterobilayers have revealed the presence of hybridized

    更新日期:2020-04-06
  • Layer-resolved ultrafast extreme ultraviolet measurement of hole transport in a Ni-TiO2-Si photoanode
    Sci. Adv. (IF 12.804) Pub Date : 2020-04-03
    Scott K. Cushing, Ilana J. Porter, Bethany R. de Roulet, Angela Lee, Brett M. Marsh, Szilard Szoke, Mihai E. Vaida, Stephen R. Leone

    Metal oxide semiconductor junctions are central to most electronic and optoelectronic devices, but ultrafast measurements of carrier transport have been limited to device-average measurements. Here, charge transport and recombination kinetics in each layer of a Ni-TiO2-Si junction is measured using the element specificity of broadband extreme ultraviolet (XUV) ultrafast pulses. After silicon photoexcitation

    更新日期:2020-04-06
  • Role of allosteric switches and adaptor domains in long-distance cross-talk and transient tunnel formation
    Sci. Adv. (IF 12.804) Pub Date : 2020-04-03
    Nandini Sharma, Navjeet Ahalawat, Padmani Sandhu, Erick Strauss, Jagannath Mondal, Ruchi Anand

    Transient tunnels that assemble and disassemble to facilitate passage of unstable intermediates in enzymes containing multiple reaction centers are controlled by allosteric cues. Using the 140-kDa purine biosynthetic enzyme PurL as a model system and a combination of biochemical and x-ray crystallographic studies, we show that long-distance communication between ~25-Å distal active sites is initiated

    更新日期:2020-04-06
  • Methanotrophic bacterial symbionts fuel dense populations of deep-sea feather duster worms (Sabellida, Annelida) and extend the spatial influence of methane seepage
    Sci. Adv. (IF 12.804) Pub Date : 2020-04-03
    Shana K. Goffredi, Ekin Tilic, Sean W. Mullin, Katherine S. Dawson, Abigail Keller, Raymond W. Lee, Fabai Wu, Lisa A. Levin, Greg W. Rouse, Erik E. Cordes, Victoria J. Orphan

    Deep-sea cold seeps are dynamic sources of methane release and unique habitats supporting ocean biodiversity and productivity. Here, we describe newly discovered animal-bacterial symbioses fueled by methane, between two species of annelid (a serpulid Laminatubus and sabellid Bispira) and distinct aerobic methane-oxidizing bacteria belonging to the Methylococcales, localized to the host respiratory

    更新日期:2020-04-06
  • A tripartite ssDNA mycovirus from a plant pathogenic fungus is infectious as cloned DNA and purified virions
    Sci. Adv. (IF 12.804) Pub Date : 2020-04-03
    Pengfei Li, Shuangchao Wang, Lihang Zhang, Dewen Qiu, Xueping Zhou, Lihua Guo

    Here, we describe a tripartite circular single-stranded (ss) DNA mycovirus, named Fusarium graminearum gemytripvirus 1 (FgGMTV1). The genome of FgGMTV1 comprises three circular ssDNA segments (DNA-A, DNA-B, and DNA-C). Sequence alignments and phylogenetic analyses showed that FgGMTV1 is nested within the family Genomoviridae. We also constructed the first infectious DNA clones of a DNA mycovirus. Our

    更新日期:2020-04-06
  • “Skin-like” fabric for personal moisture management
    Sci. Adv. (IF 12.804) Pub Date : 2020-04-03
    L. Lao, D. Shou, Y. S. Wu, J. T. Fan

    Personal moisture management fabrics that facilitate sweat transport away from the skin are highly desirable for wearer’s comfort and performance. Here, we demonstrate a “skin-like” directional liquid transport fabric, which enables continuous one-way liquid flow through spatially distributed channels acting like “sweating glands” yet repels external liquid contaminants. The water transmission rate

    更新日期:2020-04-06
  • Massive generation of metastable bulk nanobubbles in water by external electric fields
    Sci. Adv. (IF 12.804) Pub Date : 2020-04-03
    Mohammad Reza Ghaani, Peter G. Kusalik, Niall J. English

    Nanobubbles (NBs) are nanoscopic gaseous domains than can exist on solid surfaces or in bulk liquids. They have attracted substantial attention due to their long-time (meta)stability and a high potential for real-world applications. Using an approach not previously investigated, we exploit surface-electrostatic NB formation and stabilization via application of external electric fields in gas-liquid

    更新日期:2020-04-06
  • A metal-free blue chromophore derived from plant pigments
    Sci. Adv. (IF 12.804) Pub Date : 2020-04-03
    B. C. Freitas-Dörr, C. O. Machado, A. C. Pinheiro, A. B. Fernandes, F. A. Dörr, E. Pinto, M. Lopes-Ferreira, M. Abdellah, J. Sá, L. C. Russo, F. L. Forti, L. C. P. Gonçalves, E. L. Bastos

    Blue natural pigments are rare, especially among plants. However, flowering species that evolved to attract Hymenoptera pollinators are colored by blue anthocyanin-metal complexes. Plants lacking anthocyanins are pigmented by betalains but are unable to produce blue hues. By extending the π-system of betalains, we designed a photostable and metal-free blue dye named BeetBlue that did not show toxicity

    更新日期:2020-04-06
  • Scattering of adiabatically aligned molecules by nonresonant optical standing waves
    Sci. Adv. (IF 12.804) Pub Date : 2020-04-03
    Lee Yeong Kim, Byung Gwun Jin, Tae Woo Kim, Ju Hyeon Lee, Bum Suk Zhao

    We study the effect of rotational state–dependent alignment in the scattering of molecules by optical fields. CS2 molecules in their lowest few rotational states are adiabatically aligned and transversely accelerated by a nonresonant optical standing wave. The width of the measured transverse velocity distribution increases to 160 m/s with the field intensity, while its central peak position moves

    更新日期:2020-04-06
  • Metal-free activation of molecular oxygen by covalent triazine frameworks for selective aerobic oxidation
    Sci. Adv. (IF 12.804) Pub Date : 2020-04-03
    Sara Abednatanzi, Parviz Gohari Derakhshandeh, Karen Leus, Henk Vrielinck, Freddy Callens, Johannes Schmidt, Aleksandr Savateev, Pascal Van Der Voort

    Oxygen activation is a critical step in ubiquitous heterogeneous oxidative processes, most prominently in catalysis, electrolysis, and pharmaceutical applications. We present here our findings on metal-free O2 activation on covalent triazine frameworks (CTFs) as an important class of N-rich materials. The O2 activation process was studied for the formation of aldehydes, ketones and imines. A detailed

    更新日期:2020-04-06
  • Lubricated friction around nanodefects
    Sci. Adv. (IF 12.804) Pub Date : 2020-04-03
    Clodomiro Cafolla, William Foster, Kislon Voïtchovsky

    The lubrication properties of nanoconfined liquids underpin countless natural and industrial processes. However, our current understanding of lubricated friction is still limited, especially for nonideal interfaces exhibiting nanoscale chemical and topographical defects. Here, we use atomic force microscopy to explore the equilibrium and dynamical behavior of a model lubricant, squalane, confined between

    更新日期:2020-04-06
  • Quantum biology revisited
    Sci. Adv. (IF 12.804) Pub Date : 2020-04-03
    Jianshu Cao, Richard J. Cogdell, David F. Coker, Hong-Guang Duan, Jürgen Hauer, Ulrich Kleinekathöfer, Thomas L. C. Jansen, Tomáš Mančal, R. J. Dwayne Miller, Jennifer P. Ogilvie, Valentyn I. Prokhorenko, Thomas Renger, Howe-Siang Tan, Roel Tempelaar, Michael Thorwart, Erling Thyrhaug, Sebastian Westenhoff, Donatas Zigmantas

    Photosynthesis is a highly optimized process from which valuable lessons can be learned about the operating principles in nature. Its primary steps involve energy transport operating near theoretical quantum limits in efficiency. Recently, extensive research was motivated by the hypothesis that nature used quantum coherences to direct energy transfer. This body of work, a cornerstone for the field

    更新日期:2020-04-06
  • Symmetry breaking in hydrodynamic forces drives meiotic spindle rotation in mammalian oocytes
    Sci. Adv. (IF 12.804) Pub Date : 2020-04-03
    HaiYang Wang, Yizeng Li, Jing Yang, Xing Duan, Petr Kalab, Sean X. Sun, Rong Li

    Patterned cell divisions require a precisely oriented spindle that segregates chromosomes and determines the cytokinetic plane. In this study, we investigated how the meiotic spindle orients through an obligatory rotation during meiotic division in mouse oocytes. We show that spindle rotation occurs at the completion of chromosome segregation, whereby the separated chromosome clusters each define a

    更新日期:2020-04-06
  • Goldilocks conditions required for earthquakes to trigger basaltic eruptions: Evidence from the 2015 Ambrym eruption
    Sci. Adv. (IF 12.804) Pub Date : 2020-04-03
    I. J. Hamling, G. Kilgour

    Observations indicate a strong correlation between the occurrence of volcanic eruptions and earthquakes. While increased volcanic activity has been observed following both local and distal earthquakes, some of the largest recorded earthquakes aren’t known to have triggered an eruption. Here we investigate whether an eruption and associated dike intrusion at Ambrym volcano was triggered by an Mw 6.4

    更新日期:2020-04-06
  • Vaporizable endoskeletal droplets via tunable interfacial melting transitions
    Sci. Adv. (IF 12.804) Pub Date : 2020-04-03
    Gazendra Shakya, Samuel E. Hoff, Shiyi Wang, Hendrik Heinz, Xiaoyun Ding, Mark A. Borden

    Liquid emulsion droplet evaporation is of importance for various sensing and imaging applications. The liquid-to-gas phase transformation is typically triggered thermally or acoustically by low–boiling point liquids, or by inclusion of solid structures that pin the vapor/liquid contact line to facilitate heterogeneous nucleation. However, these approaches lack precise tunability in vaporization behavior

    更新日期:2020-04-06
  • Genome elimination mediated by gene expression from a selfish chromosome
    Sci. Adv. (IF 12.804) Pub Date : 2020-04-03
    Elena Dalla Benetta, Igor Antoshechkin, Ting Yang, Hoa Quang My Nguyen, Patrick M. Ferree, Omar S. Akbari

    Numerous plants and animals harbor selfish B chromosomes that “drive” or transmit themselves at super-Mendelian frequencies, despite long-term fitness costs to the organism. Currently, it is unknown how B chromosome drive is mediated, and whether B-gene expression plays a role. We used modern sequencing technologies to analyze the fine-scale sequence composition and expression of paternal sex ratio

    更新日期:2020-04-06
  • Fluctuation-induced force in homogeneous isotropic turbulence
    Sci. Adv. (IF 12.804) Pub Date : 2020-04-03
    Vamsi Spandan, Daniel Putt, Rodolfo Ostilla-Mónico, Alpha A. Lee

    Understanding force generation in nonequilibrium systems is a notable challenge in statistical physics. We uncover a fluctuation-induced force between two plates immersed in homogeneous isotropic turbulence using direct numerical simulations. The force is a nonmonotonic function of plate separation. The mechanism of force generation reveals an intriguing analogy with fluctuation-induced forces: In

    更新日期:2020-04-06
  • Inhibition of protective immunity against Staphylococcus aureus infection by MHC-restricted immunodominance is overcome by vaccination
    Sci. Adv. (IF 12.804) Pub Date : 2020-04-01
    Youhui Si, Fan Zhao, Pavani Beesetty, Daniela Weiskopf, Zhaotao Li, Qiaomu Tian, Maria-Luisa Alegre, Alessandro Sette, Anita S. Chong, Christopher P. Montgomery

    Recurrent Staphylococcus aureus infections are common, despite robust immune responses. S. aureus infection elicited protective antibody and T cell responses in mice that expressed the Major Histocompatibility Complex (MHC) of the H-2d haplotype, but not H-2b, demonstrating that host genetics drives individual variability. Vaccination with a-toxin or leukotoxin E (LukE) elicited similar antibody and

    更新日期:2020-04-01
  • Parallel PRC2/cPRC1 and vPRC1 pathways silence lineage-specific genes and maintain self-renewal in mouse embryonic stem cells
    Sci. Adv. (IF 12.804) Pub Date : 2020-04-01
    J. A. Zepeda-Martinez, C. Pribitzer, J. Wang, D. Bsteh, S. Golumbeanu, Q. Zhao, T. R. Burkard, B. Reichholf, S. K. Rhie, J. Jude, H. F. Moussa, J. Zuber, O. Bell

    The transcriptional repressors Polycomb repressive complex 1 (PRC1) and PRC2 are required to maintain cell fate during embryonic development. PRC1 and PRC2 catalyze distinct histone modifications, establishing repressive chromatin at shared targets. How PRC1, which consists of canonical PRC1 (cPRC1) and variant PRC1 (vPRC1) complexes, and PRC2 cooperate to silence genes and support mouse embryonic

    更新日期:2020-04-01
  • Virus-host coexistence in phytoplankton through the genomic lens
    Sci. Adv. (IF 12.804) Pub Date : 2020-04-01
    Sheree Yau, Marc Krasovec, L. Felipe Benites, Stephane Rombauts, Mathieu Groussin, Emmelien Vancaester, Jean-Marc Aury, Evelyne Derelle, Yves Desdevises, Marie-Line Escande, Nigel Grimsley, Julie Guy, Hervé Moreau, Sophie Sanchez-Brosseau, Yves van de Peer, Klaas Vandepoele, Sebastien Gourbiere, Gwenael Piganeau

    Virus-microbe interactions in the ocean are commonly described by “boom and bust” dynamics, whereby a numerically dominant microorganism is lysed and replaced by a virus-resistant one. Here, we isolated a microalga strain and its infective dsDNA virus whose dynamics are characterized instead by parallel growth of both the microalga and the virus. Experimental evolution of clonal lines revealed that

    更新日期:2020-04-01
  • B cell Sirt1 deacetylates histone and non-histone proteins for epigenetic modulation of AID expression and the antibody response
    Sci. Adv. (IF 12.804) Pub Date : 2020-04-01
    Huoqun Gan, Tian Shen, Daniel P. Chupp, Julia R. Taylor, Helia N. Sanchez, Xin Li, Zhenming Xu, Hong Zan, Paolo Casali

    Activation-induced cytidine deaminase (AID) mediates immunoglobulin class switch DNA recombination (CSR) and somatic hypermutation (SHM), critical processes for maturation of the antibody response. Epigenetic factors, such as histone deacetylases (HDACs), would underpin B cell differentiation stage–specific AID expression. Here, we showed that NAD+-dependent class III HDAC sirtuin 1 (Sirt1) is highly

    更新日期:2020-04-01
  • A chemically unmodified agonistic DNA with growth factor functionality for in vivo therapeutic application
    Sci. Adv. (IF 12.804) Pub Date : 2020-04-01
    Ryosuke Ueki, Satoshi Uchida, Naoto Kanda, Naoki Yamada, Ayaka Ueki, Momoko Akiyama, Kazuko Toh, Horacio Cabral, Shinsuke Sando

    Although growth factors have great therapeutic potential because of their regenerative functions, they often have intrinsic drawbacks, such as low thermal stability and high production cost. Oligonucleotides have recently emerged as promising chemical entities for designing synthetic alternatives to growth factors. However, their applications in vivo have been recognized as a challenge because of their

    更新日期:2020-04-01
  • IL-27 signaling activates skin cells to induce innate antiviral proteins and protects against Zika virus infection
    Sci. Adv. (IF 12.804) Pub Date : 2020-04-01
    Jeffery T. Kwock, Chelsea Handfield, Jutamas Suwanpradid, Peter Hoang, Michael J. McFadden, Kevin F. Labagnara, Lauren Floyd, Jessica Shannon, Ranjitha Uppala, Mrinal K. Sarkar, Johann E. Gudjonsson, David L. Corcoran, Helen M. Lazear, Gregory Sempowski, Stacy M. Horner, Amanda S. MacLeod

    In the skin, antiviral proteins and other immune molecules serve as the first line of innate antiviral defense. Here, we identify and characterize the induction of cutaneous innate antiviral proteins in response to IL-27 and its functional role during cutaneous defense against Zika virus infection. Transcriptional and phenotypic profiling of epidermal keratinocytes treated with IL-27 demonstrated activation

    更新日期:2020-04-01
  • The unconventional biogenesis of Kv7.1-KCNE1 complexes
    Sci. Adv. (IF 12.804) Pub Date : 2020-04-01
    Anna Oliveras, Clara Serrano-Novillo, Cristina Moreno, Alicia de la Cruz, Carmen Valenzuela, Christian Soeller, Núria Comes, Antonio Felipe

    The potassium channel Kv7.1 associates with the KCNE1 regulatory subunit to trigger cardiac IKs currents. Although the Kv7.1/KCNE1 complex has received much attention, the subcellular compartment hosting the assembly is the subject of ongoing debate. Evidence suggests that the complex forms either earlier in the endoplasmic reticulum or directly at the plasma membrane. Kv7.1 and KCNE1 mutations, responsible

    更新日期:2020-04-01
  • ENL initiates multivalent phase separation of the super elongation complex (SEC) in controlling rapid transcriptional activation
    Sci. Adv. (IF 12.804) Pub Date : 2020-04-01
    Chenghao Guo, Zhuanzhuan Che, Junjie Yue, Peng Xie, Shaohua Hao, Wei Xie, Zhuojuan Luo, Chengqi Lin

    Release of paused RNA polymerase II (Pol II) requires incorporation of the positive transcription elongation factor b (P-TEFb) into the super elongation complex (SEC), thus resulting in rapid yet synchronous transcriptional activation. However, the mechanism underlying dynamic transition of P-TEFb from inactive to active state remains unclear. Here, we found that the SEC components are able to compartmentalize

    更新日期:2020-04-01
  • Force-induced gene up-regulation does not follow the weak power law but depends on H3K9 demethylation
    Sci. Adv. (IF 12.804) Pub Date : 2020-04-01
    Jian Sun, Junwei Chen, Erfan Mohagheghian, Ning Wang

    Mechanical forces play important roles in development, physiology, and diseases, but how force is transduced into gene transcription remains elusive. Here, we show that transcription of transgene DHFR or endogenous genes egr-1 and Cav1 is rapidly up-regulated in response to cyclic forces applied via integrins at low frequencies but not at 100 Hz. Gene up-regulation does not follow the weak power law

    更新日期:2020-04-01
  • There is no liberal media bias in which news stories political journalists choose to cover
    Sci. Adv. (IF 12.804) Pub Date : 2020-04-01
    Hans J. G. Hassell, John B. Holbein, Matthew R. Miles

    Is the media biased against conservatives? Although a dominant majority of journalists identify as liberals/Democrats and many Americans and public officials frequently decry supposedly high and increasing levels of media bias, little compelling evidence exists as to (i) the ideological or partisan leanings of the many journalists who fail to answer surveys and/or identify as independents and (ii)

    更新日期:2020-04-01
  • Biomechanical simulations reveal a trade-off between adaptation to glacial climate and dietary niche versatility in European cave bears
    Sci. Adv. (IF 12.804) Pub Date : 2020-04-01
    Alejandro Pérez-Ramos, Z. Jack Tseng, Aurora Grandal-D’Anglade, Gernot Rabeder, Francisco J. Pastor, Borja Figueirido

    The cave bear is one of the best known extinct large mammals that inhabited Europe during the “Ice Age,” becoming extinct ≈24,000 years ago along with other members of the Pleistocene megafauna. Long-standing hypotheses speculate that many cave bears died during their long hibernation periods, which were necessary to overcome the severe and prolonged winters of the Last Glacial. Here, we investigate

    更新日期:2020-04-01
  • Ribosome-associated vesicles: A dynamic subcompartment of the endoplasmic reticulum in secretory cells
    Sci. Adv. (IF 12.804) Pub Date : 2020-04-01
    Stephen D. Carter, Cheri M. Hampton, Robert Langlois, Roberto Melero, Zachary J. Farino, Michael J. Calderon, Wen Li, Callen T. Wallace, Ngoc Han Tran, Robert A. Grassucci, Stephanie E. Siegmund, Joshua Pemberton, Travis J. Morgenstern, Leanna Eisenman, Jenny I. Aguilar, Nili L. Greenberg, Elana S. Levy, Edward Yi, William G. Mitchell, William J. Rice, Christoph Wigge, Jyotsna Pilli, Emily W. George

    The endoplasmic reticulum (ER) is a highly dynamic network of membranes. Here, we combine live-cell microscopy with in situ cryo–electron tomography to directly visualize ER dynamics in several secretory cell types including pancreatic β-cells and neurons under near-native conditions. Using these imaging approaches, we identify a novel, mobile form of ER, ribosome-associated vesicles (RAVs), found

    更新日期:2020-04-01
  • A multifunctional surfactant catalyst inspired by hydrolases
    Sci. Adv. (IF 12.804) Pub Date : 2020-04-01
    Mitchell D. Nothling, Zeyun Xiao, Nicholas S. Hill, Mitchell T. Blyth, Ayana Bhaskaran, Marc-Antoine Sani, Andrea Espinosa-Gomez, Kevin Ngov, Jonathan White, Tim Buscher, Frances Separovic, Megan L. O’Mara, Michelle L. Coote, Luke A. Connal

    The remarkable power of enzymes to undertake catalysis frequently stems from their grouping of multiple, complementary chemical units within close proximity around the enzyme active site. Motivated by this, we report here a bioinspired surfactant catalyst that incorporates a variety of chemical functionalities common to hydrolytic enzymes. The textbook hydrolase active site, the catalytic triad, is

    更新日期:2020-04-01
  • Designer, injectable gels to prevent transplanted Schwann cell loss during spinal cord injury therapy
    Sci. Adv. (IF 12.804) Pub Date : 2020-04-01
    Laura M. Marquardt, Vanessa M. Doulames, Alice T. Wang, Karen Dubbin, Riley A. Suhar, Michael J. Kratochvil, Zachary A. Medress, Giles W. Plant, Sarah C. Heilshorn

    Transplantation of patient-derived Schwann cells is a promising regenerative medicine therapy for spinal cord injuries; however, therapeutic efficacy is compromised by inefficient cell delivery. We present a materials-based strategy that addresses three common causes of transplanted cell death: (i) membrane damage during injection, (ii) cell leakage from the injection site, and (iii) apoptosis due

    更新日期:2020-04-01
  • MAP6 is an intraluminal protein that induces neuronal microtubules to coil
    Sci. Adv. (IF 12.804) Pub Date : 2020-04-01
    Camille Cuveillier, Julie Delaroche, Maxime Seggio, Sylvie Gory-Fauré, Christophe Bosc, Eric Denarier, Maria Bacia, Guy Schoehn, Hervé Mohrbach, Igor Kulić, Annie Andrieux, Isabelle Arnal, Christian Delphin

    Neuronal activities depend heavily on microtubules, which shape neuronal processes and transport myriad molecules within them. Although constantly remodeled through growth and shrinkage events, neuronal microtubules must be sufficiently stable to maintain nervous system wiring. This stability is somehow maintained by various microtubule-associated proteins (MAPs), but little is known about how these

    更新日期:2020-04-01
  • Australopithecus afarensis endocasts suggest ape-like brain organization and prolonged brain growth
    Sci. Adv. (IF 12.804) Pub Date : 2020-04-01
    Philipp Gunz, Simon Neubauer, Dean Falk, Paul Tafforeau, Adeline Le Cabec, Tanya M. Smith, William H. Kimbel, Fred Spoor, Zeresenay Alemseged

    Human brains are three times larger, are organized differently, and mature for a longer period of time than those of our closest living relatives, the chimpanzees. Together, these characteristics are important for human cognition and social behavior, but their evolutionary origins remain unclear. To study brain growth and organization in the hominin species Australopithecus afarensis more than 3 million

    更新日期:2020-04-01
  • Measles virus nucleo- and phosphoproteins form liquid-like phase-separated compartments that promote nucleocapsid assembly
    Sci. Adv. (IF 12.804) Pub Date : 2020-04-01
    Serafima Guseva, Sigrid Milles, Malene Ringkjøbing Jensen, Nicola Salvi, Jean-Philippe Kleman, Damien Maurin, Rob W. H. Ruigrok, Martin Blackledge

    Many viruses are known to form cellular compartments, also called viral factories. Paramyxoviruses, including measles virus, colocalize their proteomic and genomic material in puncta in infected cells. We demonstrate that purified nucleoproteins (N) and phosphoproteins (P) of measles virus form liquid-like membraneless organelles upon mixing in vitro. We identify weak interactions involving intrinsically

    更新日期:2020-04-01
  • Epitope-directed antibody selection by site-specific photocrosslinking
    Sci. Adv. (IF 12.804) Pub Date : 2020-04-01
    Longxin Chen, Chaoyang Zhu, Hui Guo, Runting Li, Limeng Zhang, Zhenzhen Xing, Yue Song, Zihan Zhang, Fuping Wang, Xiaofeng Liu, Yuhan Zhang, Runlin Z. Ma, Feng Wang

    Currently, there are no methods available offering solutions to select and identify antibodies binding to a specific conformational epitope of an antigen. Here, we developed a method to allow epitope-directed antibody selection from a phage display library by photocrosslinking bound antibodies to a site that specifically incorporates a noncanonical amino acid, p-benzoyl-l-phenylalanine (pBpa), on the

    更新日期:2020-04-01
  • Pretargeted delivery of PI3K/mTOR small-molecule inhibitor–loaded nanoparticles for treatment of non-Hodgkin’s lymphoma
    Sci. Adv. (IF 12.804) Pub Date : 2020-04-01
    Kin Man Au, Andrew Z. Wang, Steven I. Park

    Overactivation of the PI3K/mTOR signaling has been identified in non-Hodgkin’s lymphoma. BEZ235 is an effective dual PI3K/mTOR inhibitor, but it was withdrawn from early-phase clinical trials owing to poor solubility and on-target/off-tumor toxicity. Here, we developed a nanoparticle (NP)–based pretargeted system for the therapeutic delivery of BEZ235 to CD20- and HLA-DR–expressing lymphoma cells for

    更新日期:2020-04-01
Contents have been reproduced by permission of the publishers.
导出
全部期刊列表>>
宅家赢大奖
向世界展示您的会议墙报和演示文稿
全球疫情及响应:BMC Medicine专题征稿
新版X-MOL期刊搜索和高级搜索功能介绍
化学材料学全球高引用
ACS材料视界
x-mol收录
自然科研论文编辑服务
南方科技大学
南方科技大学
舒伟
中国科学院长春应化所于聪-4-8
复旦大学
课题组网站
X-MOL
香港大学化学系刘俊治
中山大学化学工程与技术学院
试剂库存
天合科研
down
wechat
bug