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Residence time distribution in continuous virus filtration Biotechnol. Bioeng. (IF 3.8) Pub Date : 2024-03-17 Yu-Cheng Chen, Gabriele Recanati, Fernando De Mathia, Dong-Qiang Lin, Alois Jungbauer
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A retrotransposon for site-specific gene transfer Nat. Biotechnol. (IF 46.9) Pub Date : 2024-03-18 Fred Dyda, Alison B. Hickman
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World’s first TIL therapy approved Nat. Biotechnol. (IF 46.9) Pub Date : 2024-03-15
Iovance Biotherapeutics has received a long-awaited go-ahead from the US Food and Drug Administration for its tumor-infiltrating lymphocyte (TIL) cancer therapy. The approval for Amtagvi (lifileucel) for treating patients with unresectable or metastatic melanoma is a milestone: it marks the first immune cell therapy approved for solid tumors, and it is also the first made from TILs. Amtagvi is a living
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Towards on-skin analysis of sweat for managing disorders of substance abuse Nat. Biomed. Eng. (IF 28.1) Pub Date : 2024-03-18 Noe Brasier, Juliane R. Sempionatto, Steven Bourke, George Havenith, Dietmar Schaffarczyk, Jörg Goldhahn, Christian Lüscher, Wei Gao
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Miniaturized implantable temperature sensors for the long-term monitoring of chronic intestinal inflammation Nat. Biomed. Eng. (IF 28.1) Pub Date : 2024-03-18 Surabhi R. Madhvapathy, Matthew I. Bury, Larry W. Wang, Joanna L. Ciatti, Raudel Avila, Yonggang Huang, Arun K. Sharma, John A. Rogers
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Bacteria-mediated resistance of neutrophil extracellular traps to enzymatic degradation drives the formation of dental calculi Nat. Biomed. Eng. (IF 28.1) Pub Date : 2024-03-15 Mei-chen Wan, Kai Jiao, Yi-na Zhu, Qian-qian Wan, Yi-peng Zhang, Long-zhang Niu, Chen Lei, Jing-han Song, Wei-cheng Lu, Hua-jie Liu, Zhao-yang Ren, Franklin Tay, Li-na Niu
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Supercharging T cell therapy with cancer mutations Nat. Biotechnol. (IF 46.9) Pub Date : 2024-03-15 Iris Marchal
T cell therapies are still hindered by poor T cell persistence and function, making them largely ineffective against solid tumors. Human cancerous T cells acquire mutations that increase their fitness and evade immune challenges in similar situations to those faced by therapeutic T cells. Writing in Nature, Garcia and colleagues exploit the fitness-enhancing abilities of these cancer mutations by incorporating
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US bill targets Chinese biotechs Nat. Biotechnol. (IF 46.9) Pub Date : 2024-03-15
The United States is seeking to prevent four Chinese biotech companies from doing business in the country, citing them as “companies of concern” that threaten national security. The Biosecure Act, introduced in both the Senate (S.3558) in December and House of Representatives (H.R.7085) in January, would prohibit the federal government from contracting with certain biotech providers connected to foreign
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Wearable technology and devices Nat. Biotechnol. (IF 46.9) Pub Date : 2024-03-15
Recent patents relating to wearable technology and devices for patient monitoring and treatment of health conditions.
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A synthetic antibiotic overcomes antimicrobial resistance Nat. Biotechnol. (IF 46.9) Pub Date : 2024-03-15 Iris Marchal
Many small-molecule antibiotics function by disrupting bacterial ribosomes, but bacteria develop resistance by modifying ribosomes to reduce the binding affinity of these molecules. Writing in Science, Wu et al. present a solution to this challenge by engineering a synthetic antibiotic that remains locked in an optimal conformation that boosts ribosomal binding. The authors designed the molecule cresomycin
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In vivo CRISPR agent cuts HAE attacks 95% Nat. Biotechnol. (IF 46.9) Pub Date : 2024-03-15
A CRISPR–Cas9-based gene editing therapy from Intellia Therapeutics reduced monthly swelling attacks by 95% in people with hereditary angioedema (HAE). The results from a small phase 1 trial were published in the New England Journal of Medicine in February. HAE is a rare genetic disorder characterized by recurrent bouts of subcutaneous and submucosal swelling that can be life threatening. Kallikrein
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Predicting the structure of large protein complexes Nat. Biotechnol. (IF 46.9) Pub Date : 2024-03-15 Iris Marchal
Deep learning models like RoseTTAFold and AlphaFold2 allow highly accurate protein structure prediction, but large protein assemblies remain hard to predict because of their size and complex subunit interactions. In a study published in Nature Methods, Shor and Scheidman-Duhovny introduce CombFold, a combinatorial and hierarchical assembly algorithm that predicts structures of large protein complexes
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Cell-based coffee future-proofs world’s favorite brew Nat. Biotechnol. (IF 46.9) Pub Date : 2024-03-15
Lior Raviv, Pluri’s chief technical officer, says: “We hypothesized we could take the cells from the plant and put them in a bioreactor [to grow coffee].” Through their work in cell therapy and cultivated meat, the Pluri team knew that not all cells like the same growing conditions. Taking plant cell samples, they made cell lines and, instead of growing them swirling around in suspension culture, they
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Biotech news from around the world Nat. Biotechnol. (IF 46.9) Pub Date : 2024-03-15
Saudi Arabia announces a plan to become a biotech leader in the Middle East and North Africa region by 2030 and an international biotech hub by 2040. Its National Biotechnology Strategy aims to grow the country’s capabilities in vaccines, biomanufacturing, genomics and plant optimization to increase job creation and drive economic growth and diversification. The Ministry of Health and Welfare invests
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People Nat. Biotechnol. (IF 46.9) Pub Date : 2024-03-15
Recent moves of note in and around the biotech and pharma industries.
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2H23 biotech job picture Nat. Biotechnol. (IF 46.9) Pub Date : 2024-03-15 Michael Francisco
A semiannual snapshot of job expansions, reductions and availability in the biotech and pharma sectors.
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Lighting the match: how a student-led career mentorship program can blaze the way for non-academic careers Nat. Biotechnol. (IF 46.9) Pub Date : 2024-03-15 Anna Bagnell, Alana MacDonald, Peter Espenshade, Mark Schenerman
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Biologic patent challenges under the America Invents Act Nat. Biotechnol. (IF 46.9) Pub Date : 2024-03-15 Victor L. Van de Wiele, Aaron S. Kesselheim, S. Sean Tu
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Innovators want pills to treat sickle cell disease. Can they match gene therapy? Nat. Biotechnol. (IF 46.9) Pub Date : 2024-03-15
Although CRISPR-based gene therapy for sickle cell disease offers transformative outcomes, drugmakers are striving to develop treatments that are easy to manufacture and can reach much larger numbers of patients.
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Glia-enriched cortical organoids implanted in mice capture astrocyte diversity Nat. Biotechnol. (IF 46.9) Pub Date : 2024-03-14
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In vivo affinity maturation of mouse B cells reprogrammed to express human antibodies Nat. Biomed. Eng. (IF 28.1) Pub Date : 2024-03-14 Yiming Yin, Yan Guo, Yuxuan Jiang, Brian Quinlan, Haiyong Peng, Gogce Crynen, Wenhui He, Lizhou Zhang, Tianling Ou, Charles C. Bailey, Michael Farzan
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Parageobacillus thermoglucosidasius as an emerging thermophilic cell factory Metab. Eng. (IF 8.4) Pub Date : 2024-03-13 Miguel Paredes-Barrada, Panagiotis Kopsiaftis, Nico J. Claassens, Richard van Kranenburg
is a thermophilic and facultatively anaerobic microbe, which is emerging as one of the most promising thermophilic model organisms for metabolic engineering. The use of thermophilic microorganisms for industrial bioprocesses provides the advantages of increased reaction rates and reduced cooling costs for bioreactors compared to their mesophilic counterparts. Moreover, it enables starch or lignocellulose
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High-throughput evaluation of genetic variants with prime editing sensor libraries Nat. Biotechnol. (IF 46.9) Pub Date : 2024-03-12 Samuel I. Gould, Alexandra N. Wuest, Kexin Dong, Grace A. Johnson, Alvin Hsu, Varun K. Narendra, Ondine Atwa, Stuart S. Levine, David R. Liu, Francisco J. Sánchez Rivera
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Improving stability of human three dimensional skin equivalents using plasma surface treatment Biotechnol. Bioeng. (IF 3.8) Pub Date : 2024-03-12 Suphanun Phuphanitcharoenkun, Fiona Louis, Yoshihiro Sowa, Michiya Matsusaki, Tanapat Palaga
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Transport‐controlled growth decoupling for self‐induced protein expression with a glycerol‐repressible genetic circuit Biotechnol. Bioeng. (IF 3.8) Pub Date : 2024-03-12 Alvaro R. Lara, Flavio Kunert, Vincent Vandenbroucke, Hilal Taymaz‐Nikerel, Luz María Martínez, Juan‐Carlos Sigala, Frank Delvigne, Guillermo Gosset, Jochen Büchs
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Continuous multi‐column capture of monoclonal antibodies with convective diffusive membrane adsorbers Biotechnol. Bioeng. (IF 3.8) Pub Date : 2024-03-12 Fabian Schmitz, Elias Knöchelmann, Thomas Kruse, Mirjana Minceva, Markus Kampmann
Downstream processing is the bottleneck in the continuous manufacturing of monoclonal antibodies (mAbs). To overcome throughput limitations, two different continuous processes with a novel convective diffusive protein A membrane adsorber (MA) were investigated: the rapid cycling parallel multi‐column chromatography (RC‐PMCC) process and the rapid cycling simulated moving bed (RC‐BioSMB) process. First
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A small-molecule TNIK inhibitor targets fibrosis in preclinical and clinical models Nat. Biotechnol. (IF 46.9) Pub Date : 2024-03-08 Feng Ren, Alex Aliper, Jian Chen, Heng Zhao, Sujata Rao, Christoph Kuppe, Ivan V. Ozerov, Man Zhang, Klaus Witte, Chris Kruse, Vladimir Aladinskiy, Yan Ivanenkov, Daniil Polykovskiy, Yanyun Fu, Eugene Babin, Junwen Qiao, Xing Liang, Zhenzhen Mou, Hui Wang, Frank W. Pun, Pedro Torres Ayuso, Alexander Veviorskiy, Dandan Song, Sang Liu, Bei Zhang, Vladimir Naumov, Xiaoqiang Ding, Andrey Kukharenko, Evgeny
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Corrigendum to “Cyclo-diphenylalanine Production in Aspergillus nidulans through Stepwise Metabolic Engineering” [Metab. Eng. 82 (2024) 147–156] Metab. Eng. (IF 8.4) Pub Date : 2024-03-11 Xiaolin Liu, Kang Li, Jing Yu, Chuanteng Ma, Qian Che, Tianjiao Zhu, Dehai Li, Blaine A. Pfeifer, Guojian Zhang
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Revealing the dynamics and mechanisms of bacterial interactions in cheese production with metabolic modelling Metab. Eng. (IF 8.4) Pub Date : 2024-03-08 Maxime Lecomte, Wenfan Cao, Julie Aubert, David James Sherman, Hélène Falentin, Clémence Frioux, Simon Labarthe
Cheese taste and flavour properties result from complex metabolic processes occurring in microbial communities. A deeper understanding of such mechanisms makes it possible to improve both industrial production processes and end-product quality through the design of microbial consortia. In this work, we caracterise the metabolism of a three-species community consisting of , and during a seven-week cheese
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Bringing a scalable adaptive hybrid modeling framework closer to industrial use: Application on a multiscale fungal fermentation Biotechnol. Bioeng. (IF 3.8) Pub Date : 2024-03-08 Thomas Rydal, Jesper Frandsen, Gisela Nadal‐Rey, Mads Orla Albæk, Pedram Ramin
Digitalization has paved the way for new paradigms such as digital shadows and digital twins for fermentation processes, opening the door for real‐time process monitoring, control, and optimization. With a digital shadow, real‐time model adaptation to accommodate complex metabolic phenomena such as metabolic shifts of a process can be monitored. Despite the many benefits of digitalization, the potential
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Enhancing real‐time cell culture monitoring: Automated Raman model optimization with Taguchi method Biotechnol. Bioeng. (IF 3.8) Pub Date : 2024-03-08 Xiaoxiao Dong, Xu Yan, Yuxiang Wan, Dong Gao, Jingyu Jiao, Haibin Wang, Haibin Qu
Raman spectroscopy has found widespread usage in monitoring cell culture processes both in research and practical applications. However, commonly, preprocessing methods, spectral regions, and modeling parameters have been chosen based on experience or trial‐and‐error strategies. These choices can significantly impact the performance of the models. There is an urgent need for a simple, effective, and
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Host cell protein networks as a novel co‐elution mechanism during protein A chromatography Biotechnol. Bioeng. (IF 3.8) Pub Date : 2024-03-08 Sherin Panikulam, Alexander Hanke, Frieder Kroener, Anette Karle, Oliver Anderka, Thomas K. Villiger, Nicolas Lebesgue
Host cell proteins (HCPs) are process‐related impurities of therapeutic proteins produced in for example, Chinese hamster ovary (CHO) cells. Protein A affinity chromatography is the initial capture step to purify monoclonal antibodies or Fc‐based proteins and is most effective for HCP removal. Previously proposed mechanisms that contribute to co‐purification of HCPs with the therapeutic protein are
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Growing community across the C-suite Nat. Biotechnol. (IF 46.9) Pub Date : 2024-03-07
Women in biotech CEO positions now have resources and networks.
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Prediction of tumor-reactive T cell receptors from scRNA-seq data for personalized T cell therapy Nat. Biotechnol. (IF 46.9) Pub Date : 2024-03-07 C. L. Tan, K. Lindner, T. Boschert, Z. Meng, A. Rodriguez Ehrenfried, A. De Roia, G. Haltenhof, A. Faenza, F. Imperatore, L. Bunse, J. M. Lindner, R. P. Harbottle, M. Ratliff, R. Offringa, I. Poschke, M. Platten, E. W. Green
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Pickering emulsion biocatalysis: Bridging interfacial design with enzymatic reactions Biotechnol. Adv. (IF 16.0) Pub Date : 2024-03-07 Chengmei Yin, Xiangyao Chen, Haiyang Zhang, Yong Xue, Hao Dong, Xiangzhao Mao
Non-homogeneous enzyme-catalyzed systems are more widely used than homogeneous systems. Distinguished from the conventional biphasic approach, Pickering emulsion stabilized by ultrafine solid particles opens up an innovative platform for biocatalysis. Their vast specific surface area significantly enhances enzyme-substrate interactions, dramatically increasing catalytic efficiency. This review comprehensively
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Elucidating uptake and metabolic fate of dipeptides in CHO cell cultures using 13C labeling experiments and kinetic modeling Metab. Eng. (IF 8.4) Pub Date : 2024-03-07 Harnish Mukesh Naik, Xiangchen Cai, Pranay Ladiwala, Jayanth Venkatarama Reddy, Michael J. Betenbaugh, Maciek R. Antoniewicz
The rapidly growing market of biologics including monoclonal antibodies has stimulated the need to improve biomanufacturing processes including mammalian host systems such as Chinese Hamster Ovary (CHO) cells. Cell culture media formulations continue to be enhanced to enable intensified cell culture processes and optimize cell culture performance. Amino acids, major components of cell culture media
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ASIA: An automated stress‐inducible adaptor for enhanced stress protein expression in engineered Escherichia coli Biotechnol. Bioeng. (IF 3.8) Pub Date : 2024-03-07 Chuan‐Chieh Hsiang, I‐Son Ng
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Near-cognate tRNAs increase the efficiency and precision of pseudouridine-mediated readthrough of premature termination codons Nat. Biotechnol. (IF 46.9) Pub Date : 2024-03-06 Nan Luo, Qiang Huang, Liting Dong, Wenqing Liu, Jinghui Song, Hanxiao Sun, Hao Wu, Yuan Gao, Chengqi Yi
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After obesity drugs’ success, companies rush to preserve skeletal muscle Nat. Biotechnol. (IF 46.9) Pub Date : 2024-03-05
A growing number of companies are testing muscle-building agents to counter the side effects of dramatic weight loss and potentially to preserve lean muscle into old age.
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Severely polarized extracellular acidity around tumour cells Nat. Biomed. Eng. (IF 28.1) Pub Date : 2024-03-04 Qiang Feng, Zachary Bennett, Anthony Grichuk, Raymundo Pantoja, Tongyi Huang, Brandon Faubert, Gang Huang, Mingyi Chen, Ralph J. DeBerardinis, Baran D. Sumer, Jinming Gao
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Leveraging a Y. lipolytica naringenin chassis for biosynthesis of apigenin and associated glucoside Metab. Eng. (IF 8.4) Pub Date : 2024-03-04 Celeste B. Marsan, Sung Gyung Lee, Ankim Nguyen, Angela R. Gordillo Sierra, Sarah M. Coleman, Sierra M. Brooks, Hal S. Alper
Flavonoids are a diverse set of natural products with promising bioactivities including anti-inflammatory, anti-cancer, and neuroprotective properties. Previously, the oleaginous host has been engineered to produce high titers of the base flavonoid naringenin. Here, we leverage this host along with a set of bioconversion strains to produce the flavone apigenin and its glycosylated derivative isovitexin
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Platform development for high‐throughput optimization of perfusion processes—Part II: Variation of perfusion rate strategies in microwell plates Biotechnol. Bioeng. (IF 3.8) Pub Date : 2024-03-04 Marie Dorn, Ciara Lucas, Kerensa Klottrup‐Rees, Ken Lee, Martina Micheletti
The biopharmaceutical industry is replacing fed‐batch with perfusion processes to take advantage of reduced capital and operational costs due to the operation at high cell densities (HCD) and improved productivities. HCDs are achieved by cell retention and continuous medium exchange, which is often based on the cell‐specific perfusion rate (CSPR). To obtain a cost‐productive process the perfusion rate
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Next generation probiotics: Engineering live biotherapeutics Biotechnol. Adv. (IF 16.0) Pub Date : 2024-03-02 Sanjeeva Kumar Murali, Thomas J. Mansell
The population dynamics of the human microbiome have been associated with inflammatory bowel disease, cancer, obesity, autoimmune diseases, and many other human disease states. An emerging paradigm in treatment is the administration of live engineered organisms, also called next-generation probiotics. However, the efficacy of these microbial therapies can be limited by the organism's overall performance
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Imbalanced single-cell data integration leads to loss of biological information Nat. Biotechnol. (IF 46.9) Pub Date : 2024-03-01
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Characterizing the impacts of dataset imbalance on single-cell data integration Nat. Biotechnol. (IF 46.9) Pub Date : 2024-03-01 Hassaan Maan, Lin Zhang, Chengxin Yu, Michael J. Geuenich, Kieran R. Campbell, Bo Wang
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Neutrophils bearing adhesive polymer micropatches as a drug-free cancer immunotherapy Nat. Biomed. Eng. (IF 28.1) Pub Date : 2024-02-29 Ninad Kumbhojkar, Supriya Prakash, Tatsuya Fukuta, Kwasi Adu-Berchie, Neha Kapate, Rocky An, Solomina Darko, Vineeth Chandran Suja, Kyung Soo Park, Alexander P. Gottlieb, Michael Griffith Bibbey, Malini Mukherji, Lily Li-Wen Wang, David J. Mooney, Samir Mitragotri
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Engineering an Escherichia coli based in vivo mRNA manufacturing platform Biotechnol. Bioeng. (IF 3.8) Pub Date : 2024-02-29 Edward Curry, George Muir, Jixin Qu, Zoltán Kis, Martyn Hulley, Adam Brown
Synthetic mRNA is currently produced in standardized in vitro transcription systems. However, this one‐size‐fits‐all approach has associated drawbacks in supply chain shortages, high reagent costs, complex product‐related impurity profiles, and limited design options for molecule‐specific optimization of product yield and quality. Herein, we describe for the first time development of an in vivo mRNA
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Correction to “Synergistic co‐utilization of biomass‐derived sugars enhances aromatic amino acid production by engineered Escherichia coli” Biotechnol. Bioeng. (IF 3.8) Pub Date : 2024-02-29
Liu, A., Machas, M., Mhatre, A., Hajinajaf, N., Sarnaik, A., Nichols, N., Frazer, S., Wang, X., Varman, A. M., Nielsen, D. R. (2024). Synergistic co-utilization of biomass-derived sugars enhances aromatic amino acid production by engineered Escherichia coli. Biotechnology and Bioengineering, 121:784–794. Throughout the “Results & Discussion” section, the text “Entner-Doudoroff pathway” and the abbreviated
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Simultaneous prediction of 16 quality attributes during protein A chromatography using machine learning based Raman spectroscopy models Biotechnol. Bioeng. (IF 3.8) Pub Date : 2024-02-29 Jiarui Wang, Jingyi Chen, Joey Studts, Gang Wang
Several key technologies for advancing biopharmaceutical manufacturing depend on the successful implementation of process analytical technologies that can monitor multiple product quality attributes in a continuous in‐line setting. Raman spectroscopy is an emerging technology in the biopharma industry that promises to fit this strategic need, yet its application is not widespread due to limited success
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Morphological diversification and functional maturation of human astrocytes in glia-enriched cortical organoid transplanted in mouse brain Nat. Biotechnol. (IF 46.9) Pub Date : 2024-02-28 Meiyan Wang, Lei Zhang, Sammy Weiser Novak, Jingting Yu, Iryna S. Gallina, Lynne L. Xu, Christina K. Lim, Sarah Fernandes, Maxim N. Shokhirev, April E. Williams, Monisha D. Saxena, Shashank Coorapati, Sarah L. Parylak, Cristian Quintero, Elsa Molina, Leonardo R. Andrade, Uri Manor, Fred H. Gage
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RNA interference in the era of nucleic acid therapeutics Nat. Biotechnol. (IF 46.9) Pub Date : 2024-02-26 Vasant Jadhav, Akshay Vaishnaw, Kevin Fitzgerald, Martin A. Maier
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High titer production of gastrodin enabled by systematic refactoring of yeast genome and an antisense-transcriptional regulation toolkit Metab. Eng. (IF 8.4) Pub Date : 2024-02-28 Yang Gu, Yaru Jiang, Changfan Li, Jiang Zhu, Xueyao Lu, Jianyue Ge, Mengchen Hu, Jieying Deng, Jingbo Ma, Zhiliang Yang, Xiaoman Sun, Feng Xue, Guocheng Du, Peng Xu, He Huang
Gastrodin, a phenolic glycoside, is a prominent component of , which is renowned for its sedative, hypnotic, anticonvulsant, and neuroprotective activities. Engineering heterologous production of plant natural products in microbial host represents a safe, cost-effective, and scalable alternative to plant extraction. Here, we present the construction of an engineered yeast that achieves a high-titer
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High-level production of Rhodiola rosea characteristic component rosavin from D-glucose and L-arabinose in engineered Escherichia coli Metab. Eng. (IF 8.4) Pub Date : 2024-02-28 Lijun Li, Moshi Liu, Huiping Bi, Tao Liu
Rosavin is the characteristic component of L., an important medicinal plant used widely in the world that has been reported to possess multiple biological activities. However, the endangered status of wild Rhodiola has limited the supply of rosavin. In this work, we successfully engineered an strain to efficiently produce rosavin as an alternative production method. Firstly, cinnamate: CoA ligase from
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Genome-wide host-pathway interactions affecting cis-cis-muconic acid production in yeast Metab. Eng. (IF 8.4) Pub Date : 2024-02-28 Paul Cachera, Nikolaj Can Kurt, Andreas Røpke, Tomas Strucko, Uffe H. Mortensen, Michael K. Jensen
The success of forward metabolic engineering depends on a thorough understanding of the behaviour of a heterologous metabolic pathway within its host. We have recently described CRI-SPA, a high-throughput gene editing method enabling the delivery of a metabolic pathway to all strains of the knock-out library. CRI-SPA systematically quantifies the effect of each modified gene present in the library
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Cancer-targeting antibody–drug conjugates drive dealmaking frenzy Nat. Biotechnol. (IF 46.9) Pub Date : 2024-02-26
Improved linker technologies and broadening payload options mark a coming of age for these precision cancer therapies.
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Fresh from the biotech pipeline: record-breaking FDA approvals Nat. Biotechnol. (IF 46.9) Pub Date : 2024-02-26
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The Gompertz model and its applications in microbial growth and bioproduction kinetics: Past, present and future Biotechnol. Adv. (IF 16.0) Pub Date : 2024-02-27 Jianlong Wang, Xuan Guo
The Gompertz model, initially proposed for human mortality rates, has found various applications in growth analysis across the biotechnological field. This paper presents a comprehensive review of the Gompertz model's applications in the biotechnological field, examining its past, present, and future. The past of the Gompertz model was examined by tracing its origins to 1825, and then it underwent
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Quantitative characterization of tumor cell traction force on extracellular matrix by hydrogel microsphere stress sensor Biotechnol. Bioeng. (IF 3.8) Pub Date : 2024-02-26 Xingquan Ma, Cong Wang, Changchun Ji, Xiaoshan Cao, Yuqing Dong
Cell traction force (CTF) is a kind of active force that is a cell senses external environment and actively applies to the contact matrix which is currently a representative stress in cell–extracellular matrix (ECM) interaction. Studying the distribution and variation of CTF during cell–ECM interaction help to explain the impact of physical factors on cell behaviors from the perspective of mechanobiology
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A deep learning-based method for modeling of RNA structures from cryo-EM maps Nat. Biotechnol. (IF 46.9) Pub Date : 2024-02-23