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Microbial P450 repertoire (P450ome) and its application feasibility in pharmaceutical industry, chemical industry, and environmental protection Biotechnol. Bioeng. (IF 3.8) Pub Date : 2023-09-28 Yongfa Wang, Hao Pan, Fuhao Wang, Chen Shen
Cytochrome P450s (CYPs) are heme-thiolated enzymes that catalyze the oxidation of C-H bonds in a regio- and stereo-selective manner. CYPs are widely present in the biological world. With the completion of more biological genome sequencing, the number and types of P450 enzymes have increased rapidly. P450 in microorganisms is easy to clone and express, rich in catalytic types, and strong in substrate
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Accelerated and intensified manufacturing of an adenovirus-vectored vaccine to enable rapid outbreak response Biotechnol. Bioeng. (IF 3.8) Pub Date : 2023-09-25 Carina C. D. Joe, Rameswara R. Segireddy, Cathy Oliveira, Adam Berg, Yuanyuan Li, Dimitrios Doultsinos, Steffi Scholze, Asma Ahmad, Piergiuseppe Nestola, Julia Niemann, Alexander D. Douglas
The Coalition for Epidemic Preparedness Innovations' “100-day moonshot” aspires to launch a new vaccine within 100 days of pathogen identification, followed by large-scale vaccine availability within the “second hundred days.” Here, we describe work to optimize adenoviral vector manufacturing for rapid response, by minimizing time to clinical trial and first large-scale supply, and maximizing output
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From air to your plate: tech startups making food from atmospheric CO2 Nat. Biotechnol. (IF 46.9) Pub Date : 2023-09-26
Food tech companies are taking bacteria that capture CO2 from air to make edible and nutritious food and drink.
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Vector BioPharma: resurrecting adenoviral gene delivery Nat. Biotechnol. (IF 46.9) Pub Date : 2023-09-26
Two veteran protein engineers team up to create a new gene-delivery vehicle.
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Single-cell lineage capture across genomic modalities with CellTag-multi reveals fate-specific gene regulatory changes Nat. Biotechnol. (IF 46.9) Pub Date : 2023-09-25 Kunal Jindal, Mohd Tayyab Adil, Naoto Yamaguchi, Xue Yang, Helen C. Wang, Kenji Kamimoto, Guillermo C. Rivera-Gonzalez, Samantha A. Morris
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Dissecting key regulators of transcriptome kinetics through scalable single-cell RNA profiling of pooled CRISPR screens Nat. Biotechnol. (IF 46.9) Pub Date : 2023-09-25 Zihan Xu, Andras Sziraki, Jasper Lee, Wei Zhou, Junyue Cao
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Standardizing cassette-based deep mutagenesis by Golden Gate assembly Biotechnol. Bioeng. (IF 3.8) Pub Date : 2023-09-26 Nicolas Daffern, Irene M. Francino-Urdaniz, Zachary T. Baumer, Timothy A. Whitehead
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Construction of prophage-free and highly-transformable Limosilactobacillus reuteri strains and their use for production of 1,3-propanediol Biotechnol. Bioeng. (IF 3.8) Pub Date : 2023-09-25 Kalpana Singh, Sunghoon Park
The lactic acid bacterium Limosilactobacillus reuteri (formerly Lactobacillus reuteri) is a desirable host for the production of 1,3-propanediol (1,3-PDO) from glycerol when 1,3-PDO is used in the food or cosmetic industry. However, the production is hindered by strain instability, causing cell lysis, and difficult gene manipulation. This study reveals that the stability of L. reuteri DSM 20016 and
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Multi-lipase gene knockdown in Chinese hamster ovary cells using artificial microRNAs to reduce host cell protein mediated polysorbate degradation Biotechnol. Bioeng. (IF 3.8) Pub Date : 2023-09-25 Linus Weiß, Valerie Schmieder-Todtenhaupt, Frank Haemmerling, Daniel Lakatos, Patrick Schulz, Simon Fischer
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Identification of optimal flow rate for culture media, cell density, and oxygen toward maximization of virus production in a fed-batch baculovirus-insect cell system Biotechnol. Bioeng. (IF 3.8) Pub Date : 2023-09-25 Surbhi Sharma, Jagadeesh Mahadevan, Lopamudra Giri, Kishalay Mitra
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Enhancing the production of recombinant adeno-associated virus in synthetic cell lines through systematic characterization Biotechnol. Bioeng. (IF 3.8) Pub Date : 2023-09-25 Min Lu, Zion Lee, Yu-Chieh Lin, Ibrahim Irfanullah, Wen Cai, Wei-Shou Hu
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An extracellular glucose sensor for substrate-dependent secretion and display of cellulose-degrading enzymes Biotechnol. Bioeng. (IF 3.8) Pub Date : 2023-09-25 Pamela B. Besada-Lombana, Wilfred Chen, Nancy A. Da Silva
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On-column capping of poly dT media-tethered mRNA accomplishes high capping efficiency, enhanced mRNA recovery, and improved stability against RNase Biotechnol. Bioeng. (IF 3.8) Pub Date : 2023-09-25 Shiyi Che, Xue Feng, Zhengjun Li, Zhiguo Su, Guanghui Ma, Zhikao Li, Aibing Yu, Minsu Liu, Songping Zhang
The messenger RNA (mRNA) 5′-cap structure is indispensable for mRNA translation initiation and stability. Despite its importance, large-scale production of capped mRNA through in vitro transcription (IVT) synthesis using vaccinia capping enzyme (VCE) is challenging, due to the requirement of tedious and multiple pre-and-post separation steps causing mRNA loss and degradation. Here in the present study
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Biomass directional pyrolysis based on element economy to produce high-quality fuels, chemicals, carbon materials – A review Biotechnol. Adv. (IF 16.0) Pub Date : 2023-09-25 Huiyan Zhang, Ke Yang, Yujie Tao, Qing Yang, Lujiang Xu, Chao Liu, Longlong Ma, Rui Xiao
Biomass is regarded as the only carbon-containing renewable energy source and has performed an increasingly important role in the gradual substitution of conventional fossil energy, which also contributes to the goals of carbon neutrality. In the past decade, the academic field has paid much greater attention to the development of biomass pyrolysis technologies. However, most biomass conversion technologies
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CRISPR genetic toolkits of classical food microorganisms: Current state and future prospects Biotechnol. Adv. (IF 16.0) Pub Date : 2023-09-21 Xueqin Lv, Yang Li, Xiang Xiu, Chao Liao, Yameng Xu, Yanfeng Liu, Jianghua Li, Guocheng Du, Long Liu
Production of food-related products using microorganisms in an environmentally friendly manner is a crucial solution to global food safety and environmental pollution issues. Traditional microbial modification methods rely on artificial selection or natural mutations, which require time for repeated screening and reproduction, leading to unstable results. Therefore, it is imperative to develop rapid
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A computationally designed antigen eliciting broad humoral responses against SARS-CoV-2 and related sarbecoviruses Nat. Biomed. Eng. (IF 28.1) Pub Date : 2023-09-25 Sneha Vishwanath, George William Carnell, Matteo Ferrari, Benedikt Asbach, Martina Billmeier, Charlotte George, Maria Suau Sans, Angalee Nadesalingam, Chloe Qingzhou Huang, Minna Paloniemi, Hazel Stewart, Andrew Chan, David Arthur Wells, Patrick Neckermann, David Peterhoff, Sebastian Einhauser, Diego Cantoni, Martin Mayora Neto, Ingo Jordan, Volker Sandig, Paul Tonks, Nigel Temperton, Simon Frost,
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Allometrically scaling tissue forces drive pathological foreign-body responses to implants via Rac2-activated myeloid cells Nat. Biomed. Eng. (IF 28.1) Pub Date : 2023-09-25 Jagannath Padmanabhan, Kellen Chen, Dharshan Sivaraj, Dominic Henn, Britta A. Kuehlmann, Hudson C. Kussie, Eric T. Zhao, Anum Kahn, Clark A. Bonham, Teruyuki Dohi, Thomas C. Beck, Artem A. Trotsyuk, Zachary A. Stern-Buchbinder, Peter A. Than, Hadi S. Hosseini, Janos A. Barrera, Noah J. Magbual, Melissa C. Leeolou, Katharina S. Fischer, Seth S. Tigchelaar, John Q. Lin, David P. Perrault, Mimi R. Borrelli
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Microbial production of L-methionine and its precursors using systems metabolic engineering Biotechnol. Adv. (IF 16.0) Pub Date : 2023-09-20 Mengmeng Cai, Zhifei Liu, Zhenqiang Zhao, Hongxuan Wu, Meijuan Xu, Zhiming Rao
L-methionine is an essential amino acid with versatile applications in food, feed, cosmetics and pharmaceuticals. At present, the production of L-methionine mainly relies on chemical synthesis, which conflicts with the concern over serious environmental problems and sustainable development goals. In recent years, microbial production of natural products has been amply rewarded with the emergence and
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Co-cultivation of Saccharomyces cerevisiae strains combines advantages of different metabolic engineering strategies for improved ethanol yield Metab. Eng. (IF 8.4) Pub Date : 2023-09-24 Aafke C.A. van Aalst, Igor S. van der Meulen, Mickel L.A. Jansen, Robert Mans, Jack T. Pronk
Glycerol is the major organic byproduct of industrial ethanol production with the yeast Saccharomyces cerevisiae. Improved ethanol yields have been achieved with engineered S. cerevisiae strains in which heterologous pathways replace glycerol formation as the predominant mechanism for anaerobic re-oxidation of surplus NADH generated in biosynthetic reactions. Functional expression of heterologous phosphoribulokinase
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Fast and accurate identification of plasmids and viruses in sequencing data using geNomad Nat. Biotechnol. (IF 46.9) Pub Date : 2023-09-21
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Supervised discovery of interpretable gene programs from single-cell data Nat. Biotechnol. (IF 46.9) Pub Date : 2023-09-21 Russell Z. Kunes, Thomas Walle, Max Land, Tal Nawy, Dana Pe’er
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A DNA nanodevice for mapping sodium at single-organelle resolution Nat. Biotechnol. (IF 46.9) Pub Date : 2023-09-21 Junyi Zou, Koushambi Mitra, Palapuravan Anees, Daphne Oettinger, Joseph R. Ramirez, Aneesh Tazhe Veetil, Priyanka Dutta Gupta, Rajini Rao, Jayson J. Smith, Paschalis Kratsios, Yamuna Krishnan
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Multiplexed discrimination of SARS-CoV-2 variants via plasmonic-enhanced fluorescence in a portable and automated device Nat. Biomed. Eng. (IF 28.1) Pub Date : 2023-09-21 Ying Liu, Yang Yang, Guanghui Wang, Dou Wang, Pan-Lin Shao, Jiahu Tang, Tingzhen He, Jintao Zheng, Ruibin Hu, Yiyi Liu, Ziyi Xu, Dan Niu, Jiahui Lv, Jingkai Yang, Hongjun Xiao, Shuai Wu, Shuang He, Zhongrong Tang, Yan Liu, Meijie Tang, Xingyu Jiang, Jing Yuan, Hongjie Dai, Bo Zhang
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Towards multifunctional robotic pills Nat. Biomed. Eng. (IF 28.1) Pub Date : 2023-09-18 Rodolfo Mundaca-Uribe, Nelly Askarinam, Ronnie H. Fang, Liangfang Zhang, Joseph Wang
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Electrical-biological hybrid system for carbon efficient isobutanol production Metab. Eng. (IF 8.4) Pub Date : 2023-09-20 Tanner R. Treece, Santanu Pattanayak, Morgan M. Matson, Mateo M. Cepeda, Louise A. Berben, Shota Atsumi
We have developed an electrical-biological hybrid system wherein an engineered microorganism consumes electrocatalytically produced formate from CO2 to supplement the bioproduction of isobutanol, a valuable fuel chemical. Biological CO2 sequestration is notoriously slow compared to electrochemical CO2 reduction, while electrochemical methods struggle to generate carbon-carbon bonds which readily form
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Research progress in the detection of common foodborne hazardous substances based on functional nucleic acids biosensors Biotechnol. Bioeng. (IF 3.8) Pub Date : 2023-09-18 Zijie Chen, Zhen Liu, Jingjing Liu, Xilin Xiao
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Decoding the building blocks of cellular processes from single-cell transcriptomics data Nat. Biotechnol. (IF 46.9) Pub Date : 2023-09-21
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Precision RNA base editing with engineered and endogenous effectors Nat. Biotechnol. (IF 46.9) Pub Date : 2023-09-21 Laura S. Pfeiffer, Thorsten Stafforst
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Identification of mobile genetic elements with geNomad Nat. Biotechnol. (IF 46.9) Pub Date : 2023-09-21 Antonio Pedro Camargo, Simon Roux, Frederik Schulz, Michal Babinski, Yan Xu, Bin Hu, Patrick S. G. Chain, Stephen Nayfach, Nikos C. Kyrpides
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Detection of transcriptome-wide microRNA–target interactions in single cells with agoTRIBE Nat. Biotechnol. (IF 46.9) Pub Date : 2023-09-21 Vaishnovi Sekar, Emilio Mármol-Sánchez, Panagiotis Kalogeropoulos, Laura Stanicek, Eduardo A. Sagredo, Albin Widmark, Evangelos Doukoumopoulos, Franziska Bonath, Inna Biryukova, Marc R. Friedländer
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Detecting organelle-specific activity of potassium channels with a DNA nanodevice Nat. Biotechnol. (IF 46.9) Pub Date : 2023-09-21 Palapuravan Anees, Anand Saminathan, Ezekiel R. Rozmus, Anke Di, Asrar B. Malik, Brian P. Delisle, Yamuna Krishnan
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Peptone: finding opportunity in disorder Nat. Biotechnol. (IF 46.9) Pub Date : 2023-09-19
Combining experimental and computational tools, this company is targeting disordered regions of proteins previously thought to be undruggable.
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Subcellular compartmentalization in the biosynthesis and engineering of plant natural products Biotechnol. Adv. (IF 16.0) Pub Date : 2023-09-16 Lu Yao, Xiuming Wu, Xun Jiang, Muhammad Shan, Zhuoxiang Zhang, Yiting Li, Aiguo Yang, Yu Li, Changqing Yang
Plant natural products (PNPs) are specialized metabolites with diverse bioactivities. They are extensively used in the pharmaceutical, cosmeceutical and food industries. PNPs are synthesized in plant cells by enzymes that are distributed in different subcellular compartments with unique microenvironments, such as ions, co-factors and substrates. Plant metabolic engineering is an emerging and promising
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Controlling circuitry dictates the growth optimization of Saccharomyces cerevisiae Metab. Eng. (IF 8.4) Pub Date : 2023-09-21 Viviana Nguyen, Pu Xue, Yifei Li, Huimin Zhao, Ting Lu
Microbial growth emerges from coordinated synthesis of various cellular components from limited resources. In Saccharomyces cerevisiae, cyclic AMP (cAMP)-mediated signaling is shown to orchestrate cellular metabolism; however, it remains unclear quantitatively how the controlling circuit drives resource partition and subsequently shapes biomass growth. Here we combined experiment with mathematical
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Deep learning for metabolic pathway design Metab. Eng. (IF 8.4) Pub Date : 2023-09-19 Gahyeon Ryu, Gi Bae Kim, Taeho Yu, Sang Yup Lee
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Metabolic engineering of commensal bacteria for gut butyrate delivery and dissection of host-microbe interaction Metab. Eng. (IF 8.4) Pub Date : 2023-09-17 Xu Gong, Hongwei Geng, Yun Yang, Shuyi Zhang, Zilong He, Yubo Fan, Fengyi Yin, Zhifa Zhang, Guo-Qiang Chen
An overwhelming number of studies have reported the correlation of decreased abundance of butyrate-producing commensals with a wide range of diseases. However, the molecular-level mechanisms whereby gut butyrate causally affects the host mucosal immunity and pathogenesis were poorly understood, hindered by the lack of efficient tools to control intestinal butyrate. Here we engineered a facultative
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Large-scale pathway reconstruction and colorimetric screening accelerate cellular metabolism engineering Metab. Eng. (IF 8.4) Pub Date : 2023-09-17 Xiangxiang Wang, Yuyu Zhao, Zhaohua Hou, Xiaoxu Chen, Shuangying Jiang, Wei Liu, Xin Hu, Junbiao Dai, Guanghou Zhao
The capability to manipulate and analyze hard-wired metabolic pathways sets the pace at which we can engineer cellular metabolism. Here, we present a framework to extensively rewrite the central metabolic pathway for malonyl-CoA biosynthesis in yeast and readily assess malonyl-CoA output based on pathway-scale DNA reconstruction in combination with colorimetric screening (Pracs). We applied Pracs to
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Electroosmotic flow across nanopores for single-molecule protein sequencing Nat. Biotechnol. (IF 46.9) Pub Date : 2023-09-18
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Translocation of linearized full-length proteins through an engineered nanopore under opposing electrophoretic force Nat. Biotechnol. (IF 46.9) Pub Date : 2023-09-18 Adina Sauciuc, Blasco Morozzo della Rocca, Matthijs Jonathan Tadema, Mauro Chinappi, Giovanni Maglia
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Progress advances in the production of bio-sourced methionine and its hydroxyl analogues Biotechnol. Adv. (IF 16.0) Pub Date : 2023-09-19 Jean Marie François
The essential sulphur-containing amino acid, methionine, is becoming a mass-commodity product with an annual production that exceeded 1,500,000 tons in 2018. This amino acid is today almost exclusively produced by chemical process from fossil resources. The environmental problems caused by this industrial process, and the expected scarcity of oil resources in the coming years, have recently accelerated
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Scalable genomic data exchange and analytics with sBeacon Nat. Biotechnol. (IF 46.9) Pub Date : 2023-09-14 Anuradha Wickramarachchi, Brendan Hosking, Yatish Jain, John Grimes, Mitchell J. O’Brien, Tracey Wright, Mark A. Burgess, Victor San Kho Lin, Florian Reisinger, Oliver Hofmann, Michael Lawley, Laurence O. W. Wilson, Natalie A. Twine, Denis C. Bauer
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Mitigating transcriptional bottleneck using a constitutively active transcription factor, VP16-CREB, in mammalian cells Metab. Eng. (IF 8.4) Pub Date : 2023-09-12 Chansik Yoon, Kyoung Eun Baek, Dongil Kim, Gyun Min Lee
High-level expression of recombinant proteins in mammalian cells has long been an area of interest. Inefficient transcription machinery is often an obstacle in achieving high-level expression of recombinant proteins in mammalian cells. Synthetic promoters have been developed to improve the transcription efficiency, but have achieved limited success due to the limited availability of transcription factors
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How to curb bias in manuscript assessments Nat. Biomed. Eng. (IF 28.1) Pub Date : 2023-09-15
Leverage curiosity, open-mindedness and the deliberate seeking of feedback.
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A new chance for genome editing in Europe Nat. Biotechnol. (IF 46.9) Pub Date : 2023-09-14 Hervé Vanderschuren, Patience Chatukuta, Detlef Weigel, Devang Mehta
European universities and research institutions helped to pioneer the development of key technologies for the genetic engineering of crops1. Despite its early leading role, Europe has largely resisted the use of modern genetic technologies in agriculture. The combined implementation of an unofficial moratorium on the cultivation and import of transgenic genetically modified organisms (GMOs) (1998–2004)
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Self-organizing models of human trunk organogenesis recapitulate spinal cord and spine co-morphogenesis Nat. Biotechnol. (IF 46.9) Pub Date : 2023-09-14 Simona Gribaudo, Rémi Robert, Björn van Sambeek, Camil Mirdass, Anna Lyubimova, Kamal Bouhali, Julien Ferent, Xavier Morin, Alexander van Oudenaarden, Stéphane Nedelec
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Septerna: making another run on GPCRs Nat. Biotechnol. (IF 46.9) Pub Date : 2023-09-14
Some 700 approved therapies in the United States — roughly a third of all drugs on the market — target G-protein-coupled receptors (GPCRs). Now advances in high-throughput and structure-based screening are sparking a second golden age of GPCR-based drug discovery.
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Site-specific crosslinking and assembly of tetrameric β-glucuronidase improve glycyrrhizin hydrolysis Biotechnol. Bioeng. (IF 3.8) Pub Date : 2023-09-14 Qibin Wang, Yingying Wang, Xing Jian, Ning Wang, Chun Li, Hu Liu
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CALU-3 lung cells three-dimensionally assembled onto CellFate® matrix present angiotensin-converting enzyme-2 activity Biotechnol. Bioeng. (IF 3.8) Pub Date : 2023-09-10 Jeniffer Farias dos Santos, Emily Marques dos Reis, Fernanda Vieira Berti, Guilherme Colla, Janice Koepp, Viviane Abreu Nunes
Currently, there is a great need for the development of three-dimensional (3D) in vitro lung models. Particularly, the production of a suitable 3D model of pulmonary epithelium for understanding the pathophysiology of diseases such as the COVID-19 must consider the tissue architecture and presence, for example, of the angiotensin-converting enzyme-2 (ACE-2) in the cells. Different polymeric membranes
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Bioactive decellularized adipose matrix prepared using a rapid, nonchemical/enzymatic method for adipogenesis Biotechnol. Bioeng. (IF 3.8) Pub Date : 2023-09-10 Jizhong Yang, Jiezhang Tang, Juanli Dang, Xiangke Rong, Kai Wang, Zhaoxiang Zhang, Mengmeng Hou, Zhou Yu, Chenggang Yi
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Recent advances in upstream process development for production of recombinant adeno-associated virus Biotechnol. Bioeng. (IF 3.8) Pub Date : 2023-09-10 Jianfa Ou, Yawen Tang, Jianlin Xu, Julian Tucci, Michael C. Borys, Anurag Khetan
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Biocatalytic role of cytochrome P450s to produce antibiotics: A review Biotechnol. Bioeng. (IF 3.8) Pub Date : 2023-09-10 Anup Adhikari, Sajan Shakya, Shreesti Shrestha, Dipa Aryal, Kavi Prasad Timalsina, Dipesh Dhakal, Yogan Khatri, Niranjan Parajuli
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Role of carbon nanotubes (CNTs) in transgenic plant development Biotechnol. Bioeng. (IF 3.8) Pub Date : 2023-09-10 Praniti Pawar, Sanjana Anumalla, Suvarna Sharma
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Integrated continuous downstream process of monoclonal antibody developed by converting the batch platform process based on the process characterization Biotechnol. Bioeng. (IF 3.8) Pub Date : 2023-09-10 Fuminori Konoike, Masatoshi Taniguchi, Shuichi Yamamoto
A continuous downstream process of monoclonal antibody was developed based on the process characterization. Periodic-counter current chromatography (PCCC) with two protein A columns was used for the capture step. For low pH virus inactivation (VI), a batch reactor was employed, which can work as a surge (buffer) tank. Flow-through chromatography (FTC) with two connected columns of different separation
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Biosensor-guided discovery and engineering of metabolic enzymes Biotechnol. Adv. (IF 16.0) Pub Date : 2023-09-09 Hyun Gyu Hwang, Dae-Yeol Ye, Gyoo Yeol Jung
A variety of chemicals have been produced through metabolic engineering approaches, and enhancing biosynthesis performance can be achieved by using enzymes with high catalytic efficiency. Accordingly, a number of efforts have been made to discover enzymes in nature for various applications. In addition, enzyme engineering approaches have been attempted to suit specific industrial purposes. However
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Metabolic engineering of Synechococcus elongatus 7942 for enhanced sucrose biosynthesis Metab. Eng. (IF 8.4) Pub Date : 2023-09-09 Bo Wang, Cristal Zuniga, Michael T. Guarnieri, Karsten Zengler, Michael Betenbaugh, Jamey D. Young
The capability of cyanobacteria to produce sucrose from CO2 and light has a remarkable societal and biotechnological impact since sucrose can serve as a carbon and energy source for a variety of heterotrophic organisms and can be converted into value-added products. However, most metabolic engineering efforts have focused on understanding local pathway alterations that drive sucrose biosynthesis and
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Engineering acetylation platform for the total biosynthesis of D-amino acids Metab. Eng. (IF 8.4) Pub Date : 2023-09-09 Yanqi Bi, Jingyu Wang, Jialong Li, Hsiang-Hui Chou, Tianhua Ren, Jinlin Li, Kechun Zhang
Optically pure D-amino acids are key chemicals with various applications. Although the production of specific D-amino acids has been achieved by chemical synthesis or with in vitro enzyme catalysts, it is challenging to convert a simple carbon source into D-amino acids with high efficiency. Here, we design an artificial metabolic pathway by engineering bacteria to heterologously express racemase and
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Targeted genome editing with a DNA-dependent DNA polymerase and exogenous DNA-containing templates Nat. Biotechnol. (IF 46.9) Pub Date : 2023-09-14 Bin Liu, Xiaolong Dong, Chunwei Zheng, David Keener, Zexiang Chen, Haoyang Cheng, Jonathan K. Watts, Wen Xue, Erik J. Sontheimer
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Parkinson’s iPSC trial Nat. Biotechnol. (IF 46.9) Pub Date : 2023-09-12
The US Food and Drug Administration has given a green light to a clinical trial designed to test patient-derived induced pluripotent stem cells (iPSCs) in patients with Parkinson’s disease.
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When are your cells no longer your own? Nat. Biotechnol. (IF 46.9) Pub Date : 2023-09-12
Cell lines from human samples have historically benefitted scientific research but continue to raise questions about consent.