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Ozone therapy for the treatment of COVID-19 pneumonia: A scoping review Int. Immunopharmacol. (IF 3.943) Pub Date : 2020-12-21 Morteza Izadi; Luca Cegolon; Mohammad Javanbakht; Ali Sarafzadeh; Hassan Abolghasemi; Gholamhossein Alishiri; Shi Zhao; Behzad Einollahi; Mandana Kashaki; Nematollah Jonaidi-Jafari; Mosa Asadi; Ramezan Jafari; Saeid Fathi; Hassan Nikoueinejad; Mehrdad Ebrahimi; Sina Imanizadeh; Amir Hosein Ghazale
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Transcatheter Edge-to-Edge Repair for Treatment of Tricuspid Regurgitation J. Am. Coll. Cardiol. (IF 20.589) Pub Date : 2021-01-18 Philipp Lurz; Ralph Stephan von Bardeleben; Marcel Weber; Marta Sitges; Paul Sorajja; Jörg Hausleiter; Paolo Denti; Jean-Noël Trochu; Michael Nabauer; Gilbert H.L. Tang; Patric Biaggi; Shih-Wa Ying; Phillip M. Trusty; Abdellaziz Dahou; Rebecca T. Hahn; Georg Nickenig
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Are We Right to Believe in the Value of Transcatheter Treatment of Secondary Tricuspid Regurgitation?∗ J. Am. Coll. Cardiol. (IF 20.589) Pub Date : 2021-01-18 Erwan Donal; Guillaume Leurent; Bernard Iung
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Randomized Trial of Empagliflozin in Nondiabetic Patients With Heart Failure and Reduced Ejection Fraction J. Am. Coll. Cardiol. (IF 20.589) Pub Date : 2020-11-13 Carlos G. Santos-Gallego; Ariana P. Vargas-Delgado; Juan Antonio Requena-Ibanez; Alvaro Garcia-Ropero; Donna Mancini; Sean Pinney; Frank Macaluso; Samantha Sartori; Merce Roque; Fernando Sabatel-Perez; Anderly Rodriguez-Cordero; M. Urooj Zafar; Icilma Fergus; Farah Atallah-Lajam; Johanna P. Contreras; Cathleen Varley; Pedro R. Moreno; Vivian M. Abascal; Juan J. Badimon
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The Pleiotropic Effects of SGLT2 Inhibitors J. Am. Coll. Cardiol. (IF 20.589) Pub Date : 2021-01-18 Lee R. Goldberg
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Effect of Evolocumab on Complex Coronary Disease Requiring Revascularization J. Am. Coll. Cardiol. (IF 20.589) Pub Date : 2020-11-13 Kazuma Oyama; Remo H.M. Furtado; Antonio Fagundes; Thomas A. Zelniker; Minao Tang; Julia Kuder; Sabina A. Murphy; Andrew Hamer; Huei Wang; Anthony C. Keech; Robert P. Giugliano; Marc S. Sabatine; Brian A. Bergmark
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Cholesterol Lowering and Coronary Revascularization J. Am. Coll. Cardiol. (IF 20.589) Pub Date : 2021-01-18 E. Magnus Ohman; Michael G. Nanna
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Short-Term Exposure to Ambient Air Pollution and Mortality From Myocardial Infarction J. Am. Coll. Cardiol. (IF 20.589) Pub Date : 2021-01-18 Yuewei Liu; Jingju Pan; Chuangang Fan; Ruijun Xu; Yaqi Wang; Chang Xu; Shuguang Xie; Hai Zhang; Xiuqing Cui; Zhe Peng; Chunxiang Shi; Yunquan Zhang; Hong Sun; Yun Zhou; Lan Zhang
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Guilt by Emissions∗ J. Am. Coll. Cardiol. (IF 20.589) Pub Date : 2021-01-18 Sanjay Rajagopalan; Jagat Narula
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Compression Garment Reduces Orthostatic Tachycardia and Symptoms in Patients With Postural Orthostatic Tachycardia Syndrome J. Am. Coll. Cardiol. (IF 20.589) Pub Date : 2021-01-18 Kate M. Bourne; Robert S. Sheldon; Juliette Hall; Matthew Lloyd; Karolina Kogut; Nasia Sheikh; Juliana Jorge; Jessica Ng; Derek V. Exner; John V. Tyberg; Satish R. Raj
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Improved Acute Orthostatic Tolerance in POTS by Lower Body Compression J. Am. Coll. Cardiol. (IF 20.589) Pub Date : 2021-01-18 David G. Benditt; Richard Sutton
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Machine Learning and the Future of Cardiovascular Care J. Am. Coll. Cardiol. (IF 20.589) Pub Date : 2021-01-18 Giorgio Quer; Ramy Arnaout; Michael Henne; Rima Arnaout
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Pathological Evidence for SARS-CoV-2 as a Cause of Myocarditis J. Am. Coll. Cardiol. (IF 20.589) Pub Date : 2021-01-18 Rika Kawakami; Atsushi Sakamoto; Kenji Kawai; Andrea Gianatti; Dario Pellegrini; Ahmed Nasr; Bob Kutys; Liang Guo; Anne Cornelissen; Masayuki Mori; Yu Sato; Irene Pescetelli; Matteo Brivio; Maria Romero; Giulio Guagliumi; Renu Virmani; Aloke V. Finn
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Neural stemness contributes to cell tumorigenicity Cell Biosci. (IF 5.026) Pub Date : 2021-01-19 Liyang Xu; Min Zhang; Lihua Shi; Xiaoli Yang; Lu Chen; Ning Cao; Anhua Lei; Ying Cao
Previous studies demonstrated the dependence of cancer on nerve. Recently, a growing number of studies reveal that cancer cells share the property and regulatory network with neural stem/progenitor cells. However, relationship between the property of neural stemness and cell tumorigenicity is unknown. We show that neural stem/progenitor cells, but not non-neural embryonic or somatic stem/progenitor
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Single-cell Immune Landscape of Human Recurrent Miscarriage Genom. Proteom. Bioinform. (IF 7.051) Pub Date : 2021-01-19 Feiyang Wang; Wentong Jia; Mengjie Fan; Xuan Shao; Zhilang Li; Yongjie Liu; Yeling Ma; Yu-Xia Li; Rong Li; Qiang Tu; Yan-Ling Wang
Successful pregnancy in placental mammals substantially depends on the establishment of maternal immune tolerance to the semi-allogenic fetus. Disorders in this process are tightly associated with adverse pregnancy outcomes including recurrent miscarriage (RM). However, an in-depth understanding of the systematic and decidual immune environment in RM remains largely lacking. In this study, we utilized
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Ectopic expression of microRNA-874 represses epithelial mesenchymal transition through the NF-κB pathway via CCNE1 in cholangiocarcinoma Cell. Signal. (IF 3.968) Pub Date : 2021-01-19 Xin Pan; Gang Wang; Baoming Wang
Cholangiocarcinoma (CC) is a devastating disease associated with poor survival rate. microRNAs (miRNAs) have recently been reported to assume a great role in CC development. This research aims to explore the functions of miR-874 in regulating epithelial mesenchymal transition (EMT) in CC. In obtained CC tissues and cells, miR-784 expression was assessed by RT-qPCR, and CCNE1 expression by RT-qPCR or
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Myriocin modulates the altered lipid metabolism and storage in cystic fibrosis Cell. Signal. (IF 3.968) Pub Date : 2021-01-19 Paola Signorelli; Francesca Pivari; Matteo Barcella; Ivan Merelli; Aida Zulueta; Michele Dei Cas; Riccardo Ghidoni; Anna Caretti; Rita Paroni; Alessandra Mingione
Cystic fibrosis (CF) is a hereditary disease mostly related to ΔF508 CFTR mutation causing a proteinopathy that is characterized by multiple organ dysfunction, primarily lungs chronic inflammation, and infection. Defective autophagy and accumulation of the inflammatory lipid ceramide have been proposed as therapeutic targets. Accumulation of lipids and cholesterol was reported in the airways of CF
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Circumventing Neural Damage in a C. elegans Chemosensory Circuit Using Genetically Engineered Synapses Cell Syst. (IF 8.673) Pub Date : 2021-01-19 Ithai Rabinowitch; Bishal Upadhyaya; Aaradhya Pant; Dolev Galski; Lena Kreines; Jihong Bai
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A Platform for Experimental Precision Medicine: The Extended BXD Mouse Family Cell Syst. (IF 8.673) Pub Date : 2021-01-19 David G. Ashbrook; Danny Arends; Pjotr Prins; Megan K. Mulligan; Suheeta Roy; Evan G. Williams; Cathleen M. Lutz; Alicia Valenzuela; Casey J. Bohl; Jesse F. Ingels; Melinda S. McCarty; Arthur G. Centeno; Reinmar Hager; Johan Auwerx; Lu Lu; Robert W. Williams
The challenge of precision medicine is to model complex interactions among DNA variants, phenotypes, development, environments, and treatments. We address this challenge by expanding the BXD family of mice to 140 fully isogenic strains, creating a uniquely powerful model for precision medicine. This family segregates for 6 million common DNA variants—a level that exceeds many human populations. Because
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Astrocytes and oligodendrocytes in the thalamus jointly maintain synaptic activity by supplying metabolites Cell Rep. (IF 8.109) Pub Date : 2021-01-19 Camille Philippot; Stephanie Griemsmann; Ronald Jabs; Gerald Seifert; Helmut Kettenmann; Christian Steinhäuser
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Deep neural networks identify signaling mechanisms of ErbB-family drug resistance from a continuous cell morphology space Cell Rep. (IF 8.109) Pub Date : 2021-01-19 James Longden; Xavier Robin; Mathias Engel; Jesper Ferkinghoff-Borg; Ida Kjær; Ivan D. Horak; Mikkel W. Pedersen; Rune Linding
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Loss of floor plate Netrin-1 impairs midline crossing of corticospinal axons and leads to mirror movements Cell Rep. (IF 8.109) Pub Date : 2021-01-19 Oriane Pourchet; Marie-Pierre Morel; Quentin Welniarz; Nadège Sarrazin; Fabio Marti; Nicolas Heck; Cécile Galléa; Mohamed Doulazmi; Sergi Roig Puiggros; Juan Antonio Moreno-Bravo; Marie Vidailhet; Alain Trembleau; Philippe Faure; Alain Chédotal; Emmanuel Roze; Isabelle Dusart
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Proteome-wide identification of NEDD8 modification sites reveals distinct proteomes for canonical and atypical NEDDylation Cell Rep. (IF 8.109) Pub Date : 2021-01-19 Sofia Lobato-Gil; Jan B. Heidelberger; Chantal Maghames; Aymeric Bailly; Lorene Brunello; Manuel S. Rodriguez; Petra Beli; Dimitris P. Xirodimas
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Heat activates the AAA+ HslUV protease by melting an axial autoinhibitory plug Cell Rep. (IF 8.109) Pub Date : 2021-01-19 Vladimir Baytshtok; Xue Fei; Tsai-Ting Shih; Robert A. Grant; Justin C. Santos; Tania A. Baker; Robert T. Sauer
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Prolonged mitosis causes separase deregulation and chromosome nondisjunction Cell Rep. (IF 8.109) Pub Date : 2021-01-19 Norihisa Shindo; Makoto Otsuki; Kazuhiko S.K. Uchida; Toru Hirota
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Human intestinal tissue-resident memory T cells comprise transcriptionally and functionally distinct subsets Cell Rep. (IF 8.109) Pub Date : 2021-01-19 Michael E.B. FitzPatrick; Nicholas M. Provine; Lucy C. Garner; Kate Powell; Ali Amini; Sophie L. Irwin; Helen Ferry; Tim Ambrose; Peter Friend; Georgios Vrakas; Srikanth Reddy; Elizabeth Soilleux; Paul Klenerman; Philip J. Allan
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Critical role of Syk-dependent STAT1 activation in innate antiviral immunity Cell Rep. (IF 8.109) Pub Date : 2021-01-19 Shasha Liu; Yuan Liao; Biao Chen; Yuhai Chen; Ziding Yu; Haitao Wei; Lianfeng Zhang; Shile Huang; Paul B. Rothman; George Fu Gao; Ji-Long Chen
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The mitochondrial protein ERAL1 suppresses RNA virus infection by facilitating RIG-I-like receptor signaling Cell Rep. (IF 8.109) Pub Date : 2021-01-19 Siji Li; Ming Kuang; Luoying Chen; Yunfei Li; Shengde Liu; Hongqiang Du; Lili Cao; Fuping You
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Protective plant immune responses are elicited by bacterial outer membrane vesicles Cell Rep. (IF 8.109) Pub Date : 2021-01-19 Hannah M. McMillan; Sophia G. Zebell; Jean B. Ristaino; Xinnian Dong; Meta J. Kuehn
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Periaxonal and nodal plasticities modulate action potential conduction in the adult mouse brain Cell Rep. (IF 8.109) Pub Date : 2021-01-19 Carlie L. Cullen; Renee E. Pepper; Mackenzie T. Clutterbuck; Kimberley A. Pitman; Viola Oorschot; Loic Auderset; Alexander D. Tang; Georg Ramm; Ben Emery; Jennifer Rodger; Renaud B. Jolivet; Kaylene M. Young
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Allocentric representation in the human amygdala and ventral visual stream Cell Rep. (IF 8.109) Pub Date : 2021-01-19 Hallvard Røe Evensmoen; Lars M. Rimol; Anderson M. Winkler; Richard Betzel; Tor Ivar Hansen; Hamed Nili; Asta Håberg
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Striatal bilateral control of skilled forelimb movement Cell Rep. (IF 8.109) Pub Date : 2021-01-19 Violeta G. Lopez-Huerta; Jai A. Denton; Yoko Nakano; Omar Jaidar; Marianela Garcia-Munoz; Gordon W. Arbuthnott
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Transcriptome alterations in myotonic dystrophy frontal cortex Cell Rep. (IF 8.109) Pub Date : 2021-01-19 Brittney A. Otero; Kiril Poukalov; Ryan P. Hildebrandt; Charles A. Thornton; Kenji Jinnai; Harutoshi Fujimura; Takashi Kimura; Katharine A. Hagerman; Jacinda B. Sampson; John W. Day; Eric T. Wang
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NAD+ boosting reduces age-associated amyloidosis and restores mitochondrial homeostasis in muscle Cell Rep. (IF 8.109) Pub Date : 2021-01-19 Mario Romani; Vincenzo Sorrentino; Chang-Myung Oh; Hao Li; Tanes Imamura de Lima; Hongbo Zhang; Minho Shong; Johan Auwerx
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Trophectoderm mechanics direct epiblast shape upon embryo implantation Cell Rep. (IF 8.109) Pub Date : 2021-01-19 Antonia Weberling; Magdalena Zernicka-Goetz
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Greater epithelial ridge cells are the principal organoid-forming progenitors of the mouse cochlea Cell Rep. (IF 8.109) Pub Date : 2021-01-19 Marie Kubota; Mirko Scheibinger; Taha A. Jan; Stefan Heller
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Systematic alteration of in vitro metabolic environments reveals empirical growth relationships in cancer cell phenotypes Cell Rep. (IF 8.109) Pub Date : 2021-01-19 Karl Kochanowski; Timur Sander; Hannes Link; Jeremy Chang; Steven J. Altschuler; Lani F. Wu
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HDAC inhibition results in widespread alteration of the histone acetylation landscape and BRD4 targeting to gene bodies Cell Rep. (IF 8.109) Pub Date : 2021-01-19 Mariesa J. Slaughter; Erin K. Shanle; Abid Khan; Katrin F. Chua; Tao Hong; Lisa D. Boxer; C. David Allis; Steven Z. Josefowicz; Benjamin A. Garcia; Scott B. Rothbart; Brian D. Strahl; Ian J. Davis
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Snd3 controls nucleus-vacuole junctions in response to glucose signaling Cell Rep. (IF 8.109) Pub Date : 2021-01-19 Sergi Tosal-Castano; Carlotta Peselj; Verena Kohler; Lukas Habernig; Lisa Larsson Berglund; Mahsa Ebrahimi; F.-Nora Vögtle; Johanna Höög; Claes Andréasson; Sabrina Büttner
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The ER-embedded UBE2J1/RNF26 ubiquitylation complex exerts spatiotemporal control over the endolysosomal pathway Cell Rep. (IF 8.109) Pub Date : 2021-01-19 Tom Cremer; Marlieke L.M. Jongsma; Fredrik Trulsson; Alfred C.O. Vertegaal; Jacques Neefjes; Ilana Berlin
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Reduced peroxisomal import triggers peroxisomal retrograde signaling Cell Rep. (IF 8.109) Pub Date : 2021-01-19 Elisabeth Rackles; Michael Witting; Ignasi Forné; Xing Zhang; Judith Zacherl; Simon Schrott; Christian Fischer; Jonathan J. Ewbank; Christof Osman; Axel Imhof; Stéphane G. Rolland
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Acute stress drives global repression through two independent RNA polymerase II stalling events in Saccharomyces Cell Rep. (IF 8.109) Pub Date : 2021-01-19 Nitika Badjatia; Matthew J. Rossi; Alain R. Bataille; Chitvan Mittal; William K.M. Lai; B. Franklin Pugh
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Transcription levels of a noncoding RNA orchestrate opposing regulatory and cell fate outcomes in yeast Cell Rep. (IF 8.109) Pub Date : 2021-01-19 Fabien Moretto; N. Ezgi Wood; Minghao Chia; Cai Li; Nicholas M. Luscombe; Folkert J. van Werven
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VELCRO-IP RNA-seq reveals ribosome expansion segment function in translation genome-wide Cell Rep. (IF 8.109) Pub Date : 2021-01-19 Kathrin Leppek; Gun Woo Byeon; Kotaro Fujii; Maria Barna
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Impact of WIN site inhibitor on the WDR5 interactome Cell Rep. (IF 8.109) Pub Date : 2021-01-19 Alissa D. Guarnaccia; Kristie L. Rose; Jing Wang; Bin Zhao; Tessa M. Popay; Christina E. Wang; Kiana Guerrazzi; Salisha Hill; Chase M. Woodley; Tyler J. Hansen; Shelly L. Lorey; J. Grace Shaw; William G. Payne; April M. Weissmiller; Edward T. Olejniczak; Stephen W. Fesik; Qi Liu; William P. Tansey
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The Source of Glycolytic Intermediates in Mammalian Tissues Cell Metab. (IF 21.567) Pub Date : 2021-01-19 Tara TeSlaa; Caroline R. Bartman; Connor S.R. Jankowski; Zhaoyue Zhang; Xincheng Xu; Xi Xing; Lin Wang; Wenyun Lu; Sheng Hui; Joshua D. Rabinowitz
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Calcineurin: A star is reborn Cell Calcium (IF 4.874) Pub Date : 2021-01-12 Huiming Li; Patrick G. Hogan
The protein phosphatase calcineurin has long been familiar to the calcium community, but the definition of its physiological substrates has been far from complete. A new study rectifies this deficiency and sets the stage for new insights into the role of calcineurin in diverse cellular processes.
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The role of potassium and host calcium signaling in Toxoplasma gondii egress Cell Calcium (IF 4.874) Pub Date : 2021-01-19 Stephen A. Vella; Christina A. Moore; Zhu-Hong Li; Miryam A. Hortua Triana; Evgeniy Potapenko; Silvia N.J. Moreno
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Gq-Gi-PLCβ in cells: more than the sum of its reconstituted parts Cell Calcium (IF 4.874) Pub Date : 2021-01-18 Thomas M. Wilkie; Michael A. Hale; Sarthak Reddy
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FBXL10 promotes ERRα protein stability and proliferation of breast cancer cells by enhancing the mono-ubiquitylation of ERRα Cancer Lett. (IF 7.36) Pub Date : 2021-01-12 Yangyang Yang; Shujing Li; Bowen Li; Yanan Li; Kangkai Xia; Sattout Aman; Yuxi Yang; Bashir Ahmad; Binggong Zhao; Huijian Wu
The underlying mechanism of orphan nuclear receptor estrogen-related receptor α (ERRα) in breast cancer was investigated by identifying its interaction partners using mass spectrometry. F-box and leucine-rich repeat protein 10 (FBXL10), which modulates various physiological processes, may interact with ERRα in breast cancer. Here, we investigated the interaction between FBXL10 and ERRα, and their protein
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Long non-coding RNAs at work on telomeres: Functions and implications in cancer therapy Cancer Lett. (IF 7.36) Pub Date : 2021-01-13 Kavita Gala; Ekta Khattar
Long non-coding RNAs (lncRNAs) are known to regulate various biological processes including cancer. Cancer cells possess limitless replicative potential which is attained by telomere length maintenance while normal somatic cells have a limited lifespan because their telomeres shorten with every cell division ultimately triggering replicative senescence. Two lncRNAs have been observed to play a key
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Targeting FAPα-expressing tumor-associated mesenchymal stromal cells inhibits triple-negative breast cancer pulmonary metastasis Cancer Lett. (IF 7.36) Pub Date : 2021-01-19 Xiaobo Li; Minfeng Chen; Weijin Lu; Jun Tang; Lijuan Deng; Qing Wen; Maohua Huang; Rong Deng; Geni Ye; Wencai Ye; Dongmei Zhang
Tumor metastasis is the main cause of death in patients with triple-negative breast cancer (TNBC). Bone marrow-derived mesenchymal stem cells (BM-MSCs) have tropism towards tumor tissues, and can be converted into tumor-associated mesenchymal stromal cells (TA-MSCs) to facilitate TNBC metastasis through interactions with tumor-associated macrophages (TAMs). However, the underlying molecular mechanisms
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p53-targeted lncRNA ST7-AS1 acts as a tumour suppressor by interacting with PTBP1 to suppress the Wnt/β-catenin signalling pathway in glioma Cancer Lett. (IF 7.36) Pub Date : 2021-01-19 Jie Sheng; Xin He; Wei Yu; Yingxi Chen; Yuxiang Long; Kejian Wang; Shujuan Zhu; Qian Liu
Glioma is the most prevalent intracranial tumour, with considerable morbidity. Long non-coding RNAs are important in the biological processes of various cancers. However, little is known about ST7 antisense RNA 1 (ST7-AS1) and its role in glioma progression. ST7-AS1 expression was reduced in glioma tissues and cells in comparison to normal brain tissues. p53 transcriptionally targeted the ST7-AS1 promoter
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Tumor-tagging by oncolytic viruses: A novel strategy for CAR-T therapy against solid tumors Cancer Lett. (IF 7.36) Pub Date : 2021-01-19 Xin-Ying Tang; Yu-Shi Ding; Tao Zhou; Xu Wang; Yong Yang
Chimeric antigen receptor (CAR) T cell therapy is one of the most promising immunotherapies in the past decade. It brings hope for cure to patients with previously refractory hematological malignancies. However, when translating this strategy into non-hematologic malignancies, the antitumor activity from multiple clinical studies seemed to be subtle or transient. The less satisfying efficacy in solid
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Text type attribution modulates pre-stimulus alpha power in sentence reading Brain Lang. (IF 2.339) Pub Date : 2021-01-18 Stefan Blohm; Matthias Schlesewsky; Winfried Menninghaus; Mathias Scharinger
Prior knowledge and context-specific expectations influence the perception of sensory events, e.g., speech, as well as complex higher-order cognitive operations like text reading. Here, we focused on pre-stimulus neural activity during sentence reading to examine text type-dependent attentional bias in anticipation of written stimuli, capitalizing on the functional relevance of brain oscillations in
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Systematic approach in macrophage polarization experiments: Maintaining integrity and reproducibility using flow cytometry and sample preparation J. Immunol. Methods (IF 1.901) Pub Date : 2021-01-19 Jennifer R. McCall; Kathryn Sausman
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Knockdown of TRIM5α or TRIM11 increases lentiviral vector transduction efficiency of human Muller cells Exp. Eye Res. (IF 3.011) Pub Date : 2021-01-10 Monica M. Sauter; Curtis R. Brandt
The goal of this study was to determine the expression and distribution of the host restriction factors (RFs) TRIM5α and TRIM11 in non-human primate (NHP) neural retina tissue and the human Muller cell line MIO-M1. In addition, experiments were performed to determine the effect of TRIM5α and TRIM11 knockdown on FIVGFP transduction of MIO-M1 cells with the goal of devising strategies to increase the
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Neuroprotective effect of the somatostatin receptor 5 agonist L-817,818 on retinal ganglion cells in experimental glaucoma Exp. Eye Res. (IF 3.011) Pub Date : 2021-01-16 Yi Zhang; Na Wu; Qian Li; Xin Hu; Li Wang; Jian-Guo Sun; Zhongfeng Wang; Xing-Huai Sun
Somatostatin plays important roles in modulating neuronal functions by activating the five specific G-protein coupled receptors (sst1-sst5). Previous studies have demonstrated that sst5 were expressed in retinal ganglion cells (RGCs) and sst5 agonist attenuated the α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid-induced retinal neurotoxicity. In this study, we investigated effects and underlying
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Piezo1 plays a role in optic nerve head astrocyte reactivity Exp. Eye Res. (IF 3.011) Pub Date : 2021-01-16 Jiafeng Liu; Yong Yang; Yang Liu
Piezo1 (also known as Fam38A) is a mechanosensing channel required for mechanotransduction in various cell types. In astrocytes, Piezo1 activation is associated with the pathogenesis of central nervous system neurodegeneration. Expression of Piezo1 has been detected in mouse optic nerve head astrocytes, however, the functional role of Piezo1 has not been identified. In this study, we investigated the
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Cultured cardiac fibroblasts and myofibroblasts express Sushi Containing Domain 2 and assemble a unique fibronectin rich matrix Exp. Cell Res. (IF 3.383) Pub Date : 2021-01-14 Eric G. Schmuck; Sushmita Roy; Anisa Dhillon; Sydney Walker; Keith Spinali; Sophia Colevas; Tianhua Zhou; Gagan Chhabra; Yuming Liu; Md Abdul Kader Sagar; Charlie J. Childs; John A. Kink; Kevin W. Eliceiri; Peiman Hematti; Amish N. Raval
Cardiac fibroblasts and myofibroblasts assemble and maintain extracellular matrix during normal development and following injury. Culture expansion of these cells yield a bioengineered matrix that could lead to intriguing therapeutic opportunities. For example, we reported that cultured rat cardiac fibroblasts form a matrix that can be used to delivery therapeutic stem cells. Furthermore, we reported