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LPCAT1-mediated membrane phospholipid remodelling promotes ferroptosis evasion and tumour growth Nat. Cell Biol. (IF 21.3) Pub Date : 2024-04-26 Ziwen Li, Yameng Hu, Haiqing Zheng, Man Li, Yuanji Liu, Rongni Feng, Xincheng Li, Shuxia Zhang, Miaoling Tang, Meisongzhu Yang, Ruyuan Yu, Yingru Xu, Xinyi Liao, Suwen Chen, Wanying Qian, Qiliang Zhang, Daolin Tang, Bo Li, Libing Song, Jun Li
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The cGAS-Ku80 complex regulates the balance between two end joining subpathways Cell Death Differ. (IF 12.4) Pub Date : 2024-04-25 Haiping Zhang, Lijun Jiang, Xinyi Du, Zhen Qian, Guizhu Wu, Ying Jiang, Zhiyong Mao
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Photoregulatory protein kinases fine-tune plant photomorphogenesis by directing a bifunctional phospho-code on HY5 in Arabidopsis Dev. Cell (IF 11.8) Pub Date : 2024-04-26 Nan Zhang, Chuang-Qi Wei, Da-Jin Xu, Zhi-Ping Deng, Ya-Chao Zhao, Lian-Feng Ai, Ying Sun, Zhi-Yong Wang, Sheng-Wei Zhang
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New and emerging treatments for metabolic dysfunction-associated steatohepatitis Cell Metab. (IF 29.0) Pub Date : 2024-04-25 Monica A. Tincopa, Quentin M. Anstee, Rohit Loomba
No Abstract
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Exploratory physiological experiments are not clinical trials Cell Metab. (IF 29.0) Pub Date : 2024-04-25 Erik A. Richter, David E. James, John P. Kirwan, Juleen R. Zierath
No Abstract
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Epithelial UNC-23 limits mechanical stress to maintain glia-neuron architecture in C. elegans Dev. Cell (IF 11.8) Pub Date : 2024-04-25 Cecilia G. Martin, James S. Bent, Tyler Hill, Irini Topalidou, Aakanksha Singhvi
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The Drosophila Hippo pathway transcription factor Scalloped and its co-factors alter each other’s chromatin binding dynamics and transcription in vivo Dev. Cell (IF 11.8) Pub Date : 2024-04-25 Samuel A. Manning, Benjamin Kroeger, Qiji Deng, Elliot Brooks, Yoshana Fonseka, Elizabeth Hinde, Kieran F. Harvey
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The Zn2+ transporter ZIP7 enhances endoplasmic-reticulum-associated protein degradation and prevents neurodegeneration in Drosophila Dev. Cell (IF 11.8) Pub Date : 2024-04-25 Xiaoran Guo, Morgan Mutch, Alba Yurani Torres, Maddalena Nano, Nishi Rauth, Jacob Harwood, Drew McDonald, Zijing Chen, Craig Montell, Wei Dai, Denise J. Montell
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Cryo-EM structures of membrane-bound dynamin in a post-hydrolysis state primed for membrane fission Dev. Cell (IF 11.8) Pub Date : 2024-04-24 John R. Jimah, Nidhi Kundu, Abigail E. Stanton, Kem A. Sochacki, Bertram Canagarajah, Lieza Chan, Marie-Paule Strub, Huaibin Wang, Justin W. Taraska, Jenny E. Hinshaw
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Endothelial progenitor cells control remodeling of uterine spiral arteries for the establishment of utero-placental circulation Dev. Cell (IF 11.8) Pub Date : 2024-04-24 Bin Tan, Li Lin, Yu Yuan, Yao Long, Yi Kang, Biao Huang, Li-Fei Huang, Jian-Hua Li, Chao Tong, Hong-Bo Qi
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TM7SF3 controls TEAD1 splicing to prevent MASH-induced liver fibrosis Cell Metab. (IF 29.0) Pub Date : 2024-04-25 Roi Isaac, Gautam Bandyopadhyay, Theresa V. Rohm, Sion Kang, Jinyue Wang, Narayan Pokhrel, Sadatsugu Sakane, Rizaldy Zapata, Avraham M. Libster, Yaron Vinik, Asres Berhan, Tatiana Kisseleva, Zea Borok, Yehiel Zick, Francesca Telese, Nicholas J.G. Webster, Jerrold M. Olefsky
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Immunological regulation of skeletal muscle adaptation to exercise Cell Metab. (IF 29.0) Pub Date : 2024-04-25 P. Kent Langston, Diane Mathis
Exercise has long been acknowledged for its powerful disease-preventing, health-promoting effects. However, the cellular and molecular mechanisms responsible for the beneficial effects of exercise are not fully understood. Inflammation is a component of the stress response to exercise. Recent work has revealed that such inflammation is not merely a symptom of exertion; rather, it is a key regulator
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Human anti-PSCA CAR macrophages possess potent antitumor activity against pancreatic cancer Cell Stem Cell (IF 23.9) Pub Date : 2024-04-24 Zahir Shah, Lei Tian, Zhixin Li, Lewei Jin, Jianying Zhang, Zhenlong Li, Tasha Barr, Hejun Tang, Mingye Feng, Michael A. Caligiuri, Jianhua Yu
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A temporal perspective for tumor-associated macrophage identities and functions Cancer Cell (IF 50.3) Pub Date : 2024-04-25 Camille Blériot, Garett Dunsmore, Direna Alonso-Curbelo, Florent Ginhoux
Cancer is a progressive disease that can develop and evolve over decades, with inflammation playing a central role at each of its stages, from tumor initiation to metastasis. In this context, macrophages represent well-established bridges reciprocally linking inflammation and cancer via an array of diverse functions that have spurred efforts to classify them into subtypes. Here, we discuss the intertwines
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Molecular subtypes as potential biomarkers in renal cell carcinoma Cancer Cell (IF 50.3) Pub Date : 2024-04-25 Chadi Hage Chehade, Neeraj Agarwal
The increasing number of approved treatment combinations for metastatic renal cell carcinoma highlights the need for actionable biomarkers to guide treatment selection. In this issue of Cancer Cell, Saliby et al. validate the distinct clinico-genomic profiles of expression-based molecular clusters identified in the IMmotion151 trial in the JAVELIN Renal 101 dataset.
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Tumor cell-intrinsic epigenetic SETpoint of cancer-associated fibroblasts Cancer Cell (IF 50.3) Pub Date : 2024-04-25 Xiongfeng Chen, Huocong Huang
Cancer-associated fibroblasts (CAFs) exhibit spatial and functional diversity. Here, Niu et al. unveil SETD2’s function in lipid metabolism and CAF heterogeneity in pancreatic ductal adenocarcinoma. SETD2 deficiency boosts oxidative phosphorylation activity, prompting lipid-laden CAF formation through BMP2 signaling, offering promising therapeutic avenues in personalized cancer treatment.
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Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers Cancer Cell (IF 50.3) Pub Date : 2024-04-25 Sarah T. Diepstraten, Yin Yuan, John E. La Marca, Savannah Young, Catherine Chang, Lauren Whelan, Aisling M. Ross, Karla C. Fischer, Giovanna Pomilio, Rhiannon Morris, Angela Georgiou, Veronique Litalien, Fiona C. Brown, Andrew W. Roberts, Andreas Strasser, Andrew H. Wei, Gemma L. Kelly
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Regulation of mitochondrial fission by fatty acyl-coenzyme A Nat. Cell Biol. (IF 21.3) Pub Date : 2024-04-23
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Zeb1-controlled metabolic plasticity enables remodeling of chromatin accessibility in the development of neuroendocrine prostate cancer Cell Death Differ. (IF 12.4) Pub Date : 2024-04-23 Deng Wang, Genyu Du, Xinyu Chen, Jinming Wang, Kaiyuan Liu, Huifang Zhao, Chaping Cheng, Yuman He, Na Jing, Penghui Xu, Wei Bao, Xialian Xi, Yingchao Zhang, Nan Wang, Yiyun Liu, Yujiao Sun, Kai Zhang, Pengcheng Zhang, Wei-Qiang Gao, Helen He Zhu
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Principles of chromosome organization for meiotic recombination Mol. Cell (IF 16.0) Pub Date : 2024-04-23 Mathilde Biot, Attila Toth, Christine Brun, Leon Guichard, Bernard de Massy, Corinne Grey
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DDX20 is required for cell-cycle reentry of prospermatogonia and establishment of spermatogonial stem cell pool during testicular development in mice Dev. Cell (IF 11.8) Pub Date : 2024-04-23 Dingfeng Zou, Kai Li, Luying Su, Jun Liu, Yan Lu, Rong Huang, Mengzhen Li, Xinyu Mang, Qi Geng, Pengyu Li, Jielin Tang, Zhixin Yu, Zexuan Zhang, Dingyao Chen, Shiying Miao, Jia Yu, Wei Yan, Wei Song
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Microglial lipid droplet accumulation in tauopathy brain is regulated by neuronal AMPK Cell Metab. (IF 29.0) Pub Date : 2024-04-23 Yajuan Li, Daniel Munoz-Mayorga, Yuhang Nie, Ningxin Kang, Yuren Tao, Jessica Lagerwall, Carla Pernaci, Genevieve Curtin, Nicole G. Coufal, Jerome Mertens, Lingyan Shi, Xu Chen
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The senescence-associated secretory phenotype and its physiological and pathological implications Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2024-04-23 Boshi Wang, Jin Han, Jennifer H. Elisseeff, Marco Demaria
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Unlocking trophectoderm mysteries: In vivo and in vitro perspectives on human and mouse trophoblast fate induction Dev. Cell (IF 11.8) Pub Date : 2024-04-22 Meir Azagury, Yosef Buganim
In recent years, the pursuit of inducing the trophoblast stem cell (TSC) state has gained prominence as a compelling research objective, illuminating the establishment of the trophoblast lineage and unlocking insights into early embryogenesis. In this review, we examine how advancements in diverse technologies, including in vivo time course transcriptomics, cellular reprogramming to TSC state, chemical
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Loss of GPR75 protects against non-alcoholic fatty liver disease and body fat accumulation Cell Metab. (IF 29.0) Pub Date : 2024-04-22 Alasdair Leeson-Payne, Jean Iyinikkel, Cameron Malcolm, Brian Y.H. Lam, Nadine Sommer, Georgina K.C. Dowsett, Pablo B. Martinez de Morentin, Dawn Thompson, Alasdair Mackenzie, Raffaella Chianese, Katherine Kentistou, Eugene J. Gardner, John R.B. Perry, Felix Grassmann, John R. Speakman, Justin J. Rochford, Giles S.H. Yeo, Fiona Murray, Lora K. Heisler
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Is endocytosis by caveolae dependent on dynamin? Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2024-04-22 Robert G. Parton, Justin W. Taraska, Richard Lundmark
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Cell death as an architect of adult skin stem cell niches Cell Death Differ. (IF 12.4) Pub Date : 2024-04-22 Kim Lecomte, Annagiada Toniolo, Esther Hoste
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Human DNA polymerase θ does not harbor intrinsic nuclease activity Mol. Cell (IF 16.0) Pub Date : 2024-04-18 Denisse Carvajal-Maldonado, Karl Zahn, Ryan Jensen, Richard D. Wood, Sylvie Doublié
Abstract not available
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Meet the authors: Guy Zoltsman and Rina Rosenzweig Mol. Cell (IF 16.0) Pub Date : 2024-04-18 Guy Zoltsman, Rina Rosenzweig
We talk to first and last authors Guy Zoltsman and Rina Rosenzweig about their paper, “A unique chaperoning mechanism in Class A JDPs recognizes and stabilizes mutant p53,” how every result may be important in the right context, and the importance to Rina that her lab is an encouraging and collaborative place.
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Entangling and disentangling mitotic chromosomes Mol. Cell (IF 16.0) Pub Date : 2024-04-18 Jonathan Baxter
The DNA topological challenges generated by cellular manipulation of extremely long DNA fibers remain poorly understood. In this issue of Molecular Cell, Hildebrand et al.1 describe how mitotic chromosomes are self entangled and that disentanglement requires TOP2 activity in late mitosis.
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Free ribosomal proteins as culprits for nucleolar stress Mol. Cell (IF 16.0) Pub Date : 2024-04-18 Ina Huppertz
Nucleolar stress has been consistently linked to age-related diseases. In this issue, Sirozh et al.1 find that the common molecular signature of nucleolar stress is the accumulation of free ribosomal proteins, which leads to premature aging in mice; however, it can be reversed by mTOR inhibition.
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Shining light on DHX9: UV-induced stress granules illuminate protective mechanisms for daughter cell resilience Mol. Cell (IF 16.0) Pub Date : 2024-04-18 Dylan M. Parker, Gaia R. Bublitz, Roy Parker
In a recent article in Cell, Zhou et al. investigate the origins, composition, and biological consequences of UV-induced stress granules. They find that UV-induced stress granules are triggered by the formation of RNA-protein crosslinks, uniquely contain DHX9 as a marker, form during mitosis independently of translation repression, and are enriched in intron-containing RNAs and splicing factors. Moreover
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Sequential requirements for distinct Polθ domains during theta-mediated end joining Mol. Cell (IF 16.0) Pub Date : 2024-04-18 Carel Fijen, Lea Drogalis Beckham, Dante Terino, Yuzhen Li, Dale A. Ramsden, Richard D. Wood, Sylvie Doublié, Eli Rothenberg
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No evidence for ac4C within human mRNA upon data reassessment Mol. Cell (IF 16.0) Pub Date : 2024-04-18 Joseph Georgeson, Schraga Schwartz
Cytidine acetylation (ac4C) of RNA is a post-transcriptional modification catalyzed by Nat10. Recently, an approach termed RedaC:T was employed to map ac4C in human mRNA, relying on detection of C>T mutations in WT but not in Nat10-KO cells. RedaC:T suggested widespread ac4C presence. Here, we reanalyze RedaC:T data. We find that mismatch signatures are not reproducible, as C>T mismatches are nearly
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Detection of ac4C in human mRNA is preserved upon data reassessment Mol. Cell (IF 16.0) Pub Date : 2024-04-18 Hamid Beiki, David Sturgill, Daniel Arango, Sebastien Relier, Sarah Schiffers, Shalini Oberdoerffer
We recently reported the distribution of N4-acetylcytidine (ac4C) in HeLa mRNA at base resolution through chemical reduction and the induction of C:T mismatches in sequencing (RedaC:T-seq). Our results contradicted an earlier report from Schwartz and colleagues utilizing a similar method termed ac4C-seq. Here, we revisit both datasets and reaffirm our findings. Through RedaC:T-seq reanalysis, we establish
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Retraction Notice to: Human DNA polymerase θ harbors DNA end-trimming activity critical for DNA repair Mol. Cell (IF 16.0) Pub Date : 2024-04-18 Karl E. Zahn, Ryan B. Jensen, Richard D. Wood, Sylvie Doublie
Abstract not available
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Pten, PI3K, and PtdIns(3,4,5)P3 dynamics control pulsatile actin branching in Drosophila retina morphogenesis Dev. Cell (IF 11.8) Pub Date : 2024-04-18 Jacob Malin, Christian Rosa-Birriel, Victor Hatini
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Sustained ERK signaling promotes G2 cell cycle exit and primes cells for whole-genome duplication Dev. Cell (IF 11.8) Pub Date : 2024-04-18 Adler Guerrero Zuniga, Timothy J. Aikin, Connor McKenney, Yovel Lendner, Alain Phung, Paul W. Hook, Amy Meltzer, Winston Timp, Sergi Regot
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Antagonistic control of rice immunity against distinct pathogens by the two transcription modules via salicylic acid and jasmonic acid pathways Dev. Cell (IF 11.8) Pub Date : 2024-04-18 Xiaoying Zhu, Yudan Zhao, Cheng-Min Shi, Guojuan Xu, Nana Wang, Shimin Zuo, Yuese Ning, Houxiang Kang, Wende Liu, Ruyi Wang, Shuangyong Yan, Guo-Liang Wang, Xuli Wang
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Mannose controls mesoderm specification and symmetry breaking in mouse gastruloids Dev. Cell (IF 11.8) Pub Date : 2024-04-17 Chaitanya Dingare, Dominica Cao, Jenny Jingni Yang, Berna Sozen, Benjamin Steventon
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Identification of signaling pathways that specify a subset of migrating enteric neural crest cells at the wavefront in mouse embryos Dev. Cell (IF 11.8) Pub Date : 2024-04-17 Bingyan Zhou, Chenzhao Feng, Song Sun, Xuyong Chen, Didi Zhuansun, Di Wang, Xiaosi Yu, Xinyao Meng, Jun Xiao, Luyao Wu, Jing Wang, Jing Wang, Ke Chen, Zejian Li, Jingyi You, Handan Mao, Shimin Yang, Jiaxin Zhang, Chunlei Jiao, Zhi Li, Jiexiong Feng
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QDPR deficiency drives immune suppression in pancreatic cancer Cell Metab. (IF 29.0) Pub Date : 2024-04-19 Ji Liu, Xiaowei He, Shuang Deng, Sihan Zhao, Shaoping Zhang, Ziming Chen, Chunling Xue, Lingxing Zeng, Hongzhe Zhao, Yifan Zhou, Ruihong Bai, Zilan Xu, Shaoqiu Liu, Quanbo Zhou, Mei Li, Jialiang Zhang, Xudong Huang, Rufu Chen, Liqin Wang, Dongxin Lin, Jian Zheng
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Identification of hypoxic macrophages in glioblastoma with therapeutic potential for vasculature normalization Cancer Cell (IF 50.3) Pub Date : 2024-04-18 Wenying Wang, Tianran Li, Yue Cheng, Fei Li, Shuhong Qi, Min Mao, Jingjing Wu, Qing Liu, Xiaoning Zhang, Xuegang Li, Lu Zhang, Haoyue Qi, Lan Yang, Kaidi Yang, Zhicheng He, Shuaishuai Ding, Zhongyi Qin, Ying Yang, Xi Yang, Chunhua Luo, Yu Shi
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Next questions in autophagy Nat. Cell Biol. (IF 21.3) Pub Date : 2024-04-19 Ana Maria Cuervo, Zvulun Elazar, Chantell Evans, Liang Ge, Malene Hansen, Marja Jäättelä, Jin Rui (Amos) Liang, Ben Loos, Noboru Mizushima, Anna Katharina Simon, Sharon Tooze, Tamotsu Yoshimori, Shuhei Nakamura
Our understanding of the basic mechanisms of autophagy is growing, but many questions remain about the types of autophagy cells use, when they use them, and how they function in different contexts. We asked emerging and established leaders in the field to discuss the questions and areas that they are most excited about to deepen our understanding of autophagy.
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Pooled multicolour tagging for visualizing subcellular protein dynamics Nat. Cell Biol. (IF 21.3) Pub Date : 2024-04-19 Andreas Reicher, Jiří Reiniš, Maria Ciobanu, Pavel Růžička, Monika Malik, Marton Siklos, Victoria Kartysh, Tatjana Tomek, Anna Koren, André F. Rendeiro, Stefan Kubicek
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Generation of human alveolar epithelial type I cells from pluripotent stem cells Cell Stem Cell (IF 23.9) Pub Date : 2024-04-19 Claire L. Burgess, Jessie Huang, Pushpinder S. Bawa, Konstantinos-Dionysios Alysandratos, Kasey Minakin, Lauren J. Ayers, Michael P. Morley, Apoorva Babu, Carlos Villacorta-Martin, Maria Yampolskaya, Anne Hinds, Bibek R. Thapa, Feiya Wang, Adeline Matschulat, Pankaj Mehta, Edward E. Morrisey, Xaralabos Varelas, Darrell N. Kotton
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Relaying gasdermin D to the membrane Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2024-04-17 Lisa Heinke
Reversible S-palmitoylation regulates gasdermin D cleavage, membrane translocation and pore formation to control pyroptosis following bacterial infection.
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The PML1-WDR5 axis regulates H3K4me3 marks and promotes stemness of estrogen receptor-positive breast cancer Cell Death Differ. (IF 12.4) Pub Date : 2024-04-16 Chun-Peng Pai, Han Wang, Darcie D. Seachrist, Neel Agarwal, Joshua A. Adams, Zhenghao Liu, Ruth A. Keri, Kaixiang Cao, William P. Schiemann, Hung-Ying Kao
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Nuclear RNA homeostasis promotes systems-level coordination of cell fate and senescence Cell Stem Cell (IF 23.9) Pub Date : 2024-04-16 Xue Han, Linqing Xing, Yantao Hong, Xuechun Zhang, Bo Hao, J. Yuyang Lu, Mengyuan Huang, Zuhui Wang, Shaoqian Ma, Ge Zhan, Tong Li, Xiaowen Hao, Yibing Tao, Guanwen Li, Shuqin Zhou, Zheng Zheng, Wen Shao, Yitian Zeng, Dacheng Ma, Wenhao Zhang, Zhen Xie, Haiteng Deng, Jiangwei Yan, Wulan Deng, Xiaohua Shen
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Osteopontin drives neuroinflammation and cell loss in MAPT-N279K frontotemporal dementia patient neurons Cell Stem Cell (IF 23.9) Pub Date : 2024-04-15 Osama Al-Dalahmah, Matti Lam, Julie J. McInvale, Wenhui Qu, Trang Nguyen, Jeong-Yeon Mun, Sam Kwon, Nkechime Ifediora, Aayushi Mahajan, Nelson Humala, Tristan Winters, Ellen Angeles, Kelly A. Jakubiak, Rebekka Kühn, Yoon A. Kim, Maria Caterina De Rosa, Claudia A. Doege, Fahad Paryani, Xena Flowers, Athanassios Dovas, Angeliki Mela, Hong Lu, Michael A. DeTure, Jean Paul Vonsattel, Zbigniew K. Wszolek
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Accumulation of APP C-terminal fragments causes endolysosomal dysfunction through the dysregulation of late endosome to lysosome-ER contact sites Dev. Cell (IF 11.8) Pub Date : 2024-04-15 Marine Bretou, Ragna Sannerud, Abril Escamilla-Ayala, Tom Leroy, Céline Vrancx, Zoë P. Van Acker, Anika Perdok, Wendy Vermeire, Inge Vorsters, Sophie Van Keymolen, Michelle Maxson, Benjamin Pavie, Keimpe Wierda, Eeva-Liisa Eskelinen, Wim Annaert
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In memoriam Judy Campisi: spreading cellular senescence Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2024-04-12 Fabrizio d’Adda di Fagagna
In the Journal Club, Fabrizio d’Adda di Fagagna remembers how the work of Judy Campisi changed our understanding of cellular senescence and its effect on physiology and ageing, shaping the future of this research field.
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Early insights into co-translational assembly of protein complexes Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2024-04-12 Ayala Shiber
The first evidence that the formation of protein complexes is linked to protein synthesis was already provided in the early 1960s.
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Accelerating data sharing and reuse in volume electron microscopy Nat. Cell Biol. (IF 21.3) Pub Date : 2024-04-12 Kirk James Czymmek, Ilya Belevich, Johanna Bischof, Aastha Mathur, Lucy Collinson, Eija Jokitalo
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The intersection of frailty and metabolism Cell Metab. (IF 29.0) Pub Date : 2024-04-12 Manish Mishra, Judy Wu, Alice E. Kane, Susan E. Howlett
On average, aging is associated with unfavorable changes in cellular metabolism, which are the processes involved in the storage and expenditure of energy. However, metabolic dysregulation may not occur to the same extent in all older individuals as people age at different rates. Those who are aging rapidly are at increased risk of adverse health outcomes and are said to be “frail.” Here, we explore
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Structure of the interleukin-5 receptor complex exemplifies the organizing principle of common beta cytokine signaling Mol. Cell (IF 16.0) Pub Date : 2024-04-12 Nathanael A. Caveney, Grayson E. Rodriguez, Christoph Pollmann, Thomas Meyer, Marta T. Borowska, Steven C. Wilson, Nan Wang, Xinyu Xiang, Karsten D. Householder, Pingdong Tao, Leon L. Su, Robert A. Saxton, Jacob Piehler, K. Christopher Garcia
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A validation strategy to assess the role of phase separation as a determinant of macromolecular localization Mol. Cell (IF 16.0) Pub Date : 2024-04-12 Marius Hedtfeld, Alicia Dammers, Carolin Koerner, Andrea Musacchio
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Mechanical state transitions in the regulation of tissue form and function Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2024-04-10 Yanlan Mao, Sara A. Wickström
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A CRISPRi/a screening platform to study cellular nutrient transport in diverse microenvironments Nat. Cell Biol. (IF 21.3) Pub Date : 2024-04-11 Christopher Chidley, Alicia M. Darnell, Benjamin L. Gaudio, Evan C. Lien, Anna M. Barbeau, Matthew G. Vander Heiden, Peter K. Sorger