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Sensing of mitochondrial DNA by ZBP1 promotes RIPK3-mediated necroptosis and ferroptosis in response to diquat poisoning Cell Death Differ. (IF 12.4) Pub Date : 2024-03-16 Kunmei Lai, Junjie Wang, Siyi Lin, Zhimin Chen, Guo Lin, Keng Ye, Ying Yuan, Yujiao Lin, Chuan-Qi Zhong, Jianfeng Wu, Huabin Ma, Yanfang Xu
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USP24-i-101 targeting of USP24 activates autophagy to inhibit drug resistance acquired during cancer therapy Cell Death Differ. (IF 12.4) Pub Date : 2024-03-15 Ming-Jer Young, Shao-An Wang, Yung-Ching Chen, Chia-Yu Liu, Kai-Cheng Hsu, Sin-Wei Tang, Yau-Lin Tseng, Yi-Ching Wang, Shih-Min Lin, Jan-Jong Hung
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Spatiotemporal control over cell–matrix interactions using dynamic micropatterns Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2024-03-13 Aleksi Isomursu
In this Tools of the Trade article, Isomursu (Ivaska lab) describes a new method for dynamic micropatterning, which enables investigation of cell adhesion and migration on substrates that mimic different extracellular matrix environments.
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The sirtuin-associated human senescence program converges on the activation of placenta-specific gene PAPPA Dev. Cell (IF 11.8) Pub Date : 2024-03-13 Shijia Bi, Xiaoyu Jiang, Qianzhao Ji, Zehua Wang, Jie Ren, Si Wang, Yang Yu, Ruoqi Wang, Zunpeng Liu, Junhang Liu, Jianli Hu, Guoqiang Sun, Zeming Wu, Zhiqing Diao, Jingyi Li, Liang Sun, Juan Carlos Izpisua Belmonte, Weiqi Zhang, Guang-Hui Liu, Jing Qu
Sirtuins are pro-longevity genes with chromatin modulation potential, but how these properties are connected is not well understood. Here, we generated a panel of isogeneic human stem cell lines with SIRT1–SIRT7 knockouts and found that any sirtuin deficiency leads to accelerated cellular senescence. Through large-scale epigenomic analyses, we show how sirtuin deficiency alters genome organization
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A SOX9 switch from regeneration to fibrosis Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2024-03-08 Kim Baumann
In mouse models of acute kidney injury, the outcome — scarless tissue repair versus fibrosis — depends on the activity of the transcription factor SOX9.
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WIPI4 loss linked to ferroptosis Nat. Cell Biol. (IF 21.3) Pub Date : 2024-03-07 Yang Liu, Hongyuan Yang
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Loss of WIPI4 in neurodegeneration causes autophagy-independent ferroptosis Nat. Cell Biol. (IF 21.3) Pub Date : 2024-03-07 Ye Zhu, Motoki Fujimaki, Louisa Snape, Ana Lopez, Angeleen Fleming, David C. Rubinsztein
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Lipid droplets and cellular lipid flux Nat. Cell Biol. (IF 21.3) Pub Date : 2024-03-07 Alyssa J. Mathiowetz, James A. Olzmann
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Age-related ciliopathy: Obesogenic shortening of melanocortin-4 receptor-bearing neuronal primary cilia Cell Metab. (IF 29.0) Pub Date : 2024-03-06 Manami Oya, Yoshiki Miyasaka, Yoshiko Nakamura, Miyako Tanaka, Takayoshi Suganami, Tomoji Mashimo, Kazuhiro Nakamura
Obesity is often associated with aging. However, the mechanism of age-related obesity is unknown. The melanocortin-4 receptor (MC4R) mediates leptin-melanocortin anti-obesity signaling in the hypothalamus. Here, we discovered that MC4R-bearing primary cilia of hypothalamic neurons progressively shorten with age in rats, correlating with age-dependent metabolic decline and increased adiposity. This
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Type I gamma phosphatidylinositol phosphate 5-kinase i5 controls cell sensitivity to interferon Dev. Cell (IF 11.8) Pub Date : 2024-03-06 Chinmoy Ghosh, Ruchi Kakar, Rosalie G. Hoyle, Zheng Liu, Chunqing Guo, Jiong Li, Xiang-Yang Wang, Yue Sun
The interferon signaling pathway is critical for host defense by serving diverse functions in both innate and adaptive immune responses. Here, we show that type I gamma phosphatidylinositol phosphate 5-kinase i5 (PIPKIγi5), an enzyme that synthesizes phosphatidylinositol-4,5-bisphosphate (PI4,5P), controls the sensitivity to interferon in both human and mouse cells. PIPKIγi5 directly binds to the interferon-gamma
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Author Correction: Subclonal cooperation drives metastasis by modulating local and systemic immune microenvironments Nat. Cell Biol. (IF 21.3) Pub Date : 2024-03-05 Michalina Janiszewska, Doris P. Tabassum, Zafira Castaño, Simona Cristea, Kimiyo N. Yamamoto, Natalie L. Kingston, Katherine C. Murphy, Shaokun Shu, Nicholas W. Harper, Carlos Gil Del Alcazar, Maša Alečković, Muhammad B. Ekram, Ofir Cohen, Minsuk Kwak, Yuanbo Qin, Tyler Laszewski, Adrienne Luoma, Andriy Marusyk, Kai W. Wucherpfennig, Nikhil Wagle, Rong Fan, Franziska Michor, Sandra S. McAllister, Kornelia
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Distinct pathways drive anterior hypoblast specification in the implanting human embryo Nat. Cell Biol. (IF 21.3) Pub Date : 2024-03-05 Bailey A. T. Weatherbee, Antonia Weberling, Carlos W. Gantner, Lisa K. Iwamoto-Stohl, Zoe Barnikel, Amy Barrie, Alison Campbell, Paula Cunningham, Cath Drezet, Panagiota Efstathiou, Simon Fishel, Sandra Gutiérrez Vindel, Megan Lockwood, Rebecca Oakley, Catherine Pretty, Nabiha Chowdhury, Lucy Richardson, Anastasia Mania, Lauren Weavers, Leila Christie, Kay Elder, Phillip Snell, Magdalena Zernicka-Goetz
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Hepatic malonyl-CoA synthesis restrains gluconeogenesis by suppressing fat oxidation, pyruvate carboxylation, and amino acid availability Cell Metab. (IF 29.0) Pub Date : 2024-03-05 Stanislaw Deja, Justin A. Fletcher, Chai-Wan Kim, Blanka Kucejova, Xiaorong Fu, Monika Mizerska, Morgan Villegas, Natalia Pudelko-Malik, Nicholas Browder, Melissa Inigo-Vollmer, Cameron J. Menezes, Prashant Mishra, Eric D. Berglund, Jeffrey D. Browning, John P. Thyfault, Jamey D. Young, Jay D. Horton, Shawn C. Burgess
Acetyl-CoA carboxylase (ACC) promotes prandial liver metabolism by producing malonyl-CoA, a substrate for lipogenesis and an inhibitor of CPT-1-mediated fat oxidation. We report that inhibition of ACC also produces unexpected secondary effects on metabolism. Liver-specific double ACC1/2 knockout (LDKO) or pharmacologic inhibition of ACC increased anaplerosis, tricarboxylic acid (TCA) cycle intermediates
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Supercharging cancer-fighting T cells with lithium carbonate Cell Metab. (IF 29.0) Pub Date : 2024-03-05 Yue Xu, Kaili Ma, Lianjun Zhang, Guideng Li
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Itaconate boosts malaria via induction of PD-L1 Cell Metab. (IF 29.0) Pub Date : 2024-03-05 Yukun Min, Luke A.J. O’Neill
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Carnosine facilitates lysosomal release of inhibitors of T cell surveillance Cell Metab. (IF 29.0) Pub Date : 2024-03-05 Pawel Swietach, Marja Jäättelä, Shari Pillon-Thomas, Ebbe Boedtkjer
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UCP1 and CKB are parallel players in BAT Cell Metab. (IF 29.0) Pub Date : 2024-03-05 Meng Dong, Ziyu Cheng, Wanzhu Jin
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Rim aperture of yeast autophagic membranes balances cargo inclusion with vesicle maturation Dev. Cell (IF 11.8) Pub Date : 2024-03-05 Oren Shatz, Milana Fraiberg, Damilola Isola, Shubhankar Das, Olee Gogoi, Alexandra Polyansky, Eyal Shimoni, Tali Dadosh, Nili Dezorella, Sharon G. Wolf, Zvulun Elazar
Autophagy eliminates cytoplasmic material by engulfment in membranous vesicles targeted for lysosome degradation. Nonselective autophagy coordinates sequestration of bulk cargo with the growth of the isolation membrane (IM) in a yet-unknown manner. Here, we show that in the budding yeast , IMs expand while maintaining a rim sufficiently wide for sequestration of large cargo but tight enough to mature
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ER remodelling by ER-phagy in neurogenesis Nat. Cell Biol. (IF 21.3) Pub Date : 2024-03-01 Maurizio Molinari
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Keeping a low cGAS profile in the nucleus Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2024-03-01 Eytan Zlotorynski
Harmful activity of the DNA sensor cGAS in the nucleus is suppressed by a dedicated ubiquitylation complex.
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The histone methyltransferase ASH1L protects against bone loss by inhibiting osteoclastogenesis Cell Death Differ. (IF 12.4) Pub Date : 2024-03-02 Xiaoli Zhao, Shuai Lin, Hangjiang Ren, Shenghui Sun, Liyun Zheng, Lin-Feng Chen, Zhen Wang
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Targeting stromal metabolism in pancreatic ductal adenocarcinoma Nat. Cell Biol. (IF 21.3) Pub Date : 2024-03-01 Miao Yin, Qun-Ying Lei
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Ironing out the details of ferroptosis Nat. Cell Biol. (IF 21.3) Pub Date : 2024-03-01 Donna D. Zhang
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Cancer-associated fibroblast-derived acetate promotes pancreatic cancer development by altering polyamine metabolism via the ACSS2–SP1–SAT1 axis Nat. Cell Biol. (IF 21.3) Pub Date : 2024-03-01 Divya Murthy, Kuldeep S. Attri, Surendra K. Shukla, Ravi Thakur, Nina V. Chaika, Chunbo He, Dezhen Wang, Kanupriya Jha, Aneesha Dasgupta, Ryan J. King, Scott E. Mulder, Joshua Souchek, Teklab Gebregiworgis, Vikant Rai, Rohit Patel, Tuo Hu, Sandeep Rana, Sai Sundeep Kollala, Camila Pacheco, Paul M. Grandgenett, Fang Yu, Vikas Kumar, Audrey J. Lazenby, Adrian R. Black, Susanna Ulhannan, Ajay Jain, Barish
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Combinatorial selective ER-phagy remodels the ER during neurogenesis Nat. Cell Biol. (IF 21.3) Pub Date : 2024-03-01 Melissa J. Hoyer, Cristina Capitanio, Ian R. Smith, Julia C. Paoli, Anna Bieber, Yizhi Jiang, Joao A. Paulo, Miguel A. Gonzalez-Lozano, Wolfgang Baumeister, Florian Wilfling, Brenda A. Schulman, J. Wade Harper
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A guideline on the molecular ecosystem regulating ferroptosis Nat. Cell Biol. (IF 21.3) Pub Date : 2024-02-29 Enyong Dai, Xin Chen, Andreas Linkermann, Xuejun Jiang, Rui Kang, Valerian E. Kagan, Hülya Bayir, Wan Seok Yang, Ana J. Garcia-Saez, Maria S. Ioannou, Tobias Janowitz, Qitao Ran, Wei Gu, Boyi Gan, Dmitri V. Krysko, Xiaofeng Zhu, Jiayi Wang, Stefan Krautwald, Shinya Toyokuni, Yangchun Xie, Florian R. Greten, Qing Yi, Joel Schick, Jiao Liu, Dmitry I. Gabrilovich, Jinbao Liu, Herbert J. Zeh, Donna D.
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AMBRA1 promotes intestinal inflammation by antagonizing PP4R1/PP4c mediated IKK dephosphorylation in an autophagy-independent manner Cell Death Differ. (IF 12.4) Pub Date : 2024-02-29 Weimin Xu, Zhebin Hua, Yaosheng Wang, Wenbo Tang, Weijun Ou, Fangyuan Liu, Yiqing Yang, Wenjun Ding, Zhongchuan Wang, Long Cui, Wensong Ge, Yubei Gu, Xiaolei Wang, YingWei Chen, Chen-Ying Liu, Peng Du
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Cellular and molecular control of vertebrate somitogenesis Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2024-02-28 Yuchuan Miao, Olivier Pourquié
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Mesoscale condensates organize the cytoplasm Nat. Cell Biol. (IF 21.3) Pub Date : 2024-02-29 Leshani Ahangama Liyanage, Jonathon A. Ditlev
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Evidence for widespread cytoplasmic structuring into mesoscale condensates Nat. Cell Biol. (IF 21.3) Pub Date : 2024-02-29 Felix C. Keber, Thao Nguyen, Andrea Mariossi, Clifford P. Brangwynne, Martin Wühr
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CAMSAPs and nucleation-promoting factors control microtubule release from γ-TuRC Nat. Cell Biol. (IF 21.3) Pub Date : 2024-02-29 Dipti Rai, Yinlong Song, Shasha Hua, Kelly Stecker, Jooske L. Monster, Victor Yin, Riccardo Stucchi, Yixin Xu, Yaqian Zhang, Fangrui Chen, Eugene A. Katrukha, Maarten Altelaar, Albert J. R. Heck, Michal Wieczorek, Kai Jiang, Anna Akhmanova
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APE1 inhibition enhances ferroptotic cell death and contributes to hepatocellular carcinoma therapy Cell Death Differ. (IF 12.4) Pub Date : 2024-02-28 Yu Du, Yu Zhou, Xinyu Yan, Feiyan Pan, Lingfeng He, Zhigang Guo, Zhigang Hu
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Retinoic acid receptor activation reprograms senescence response and enhances anti-tumor activity of natural killer cells Cancer Cell (IF 50.3) Pub Date : 2024-02-29 Manuel Colucci, Sara Zumerle, Silvia Bressan, Federico Gianfanti, Martina Troiani, Aurora Valdata, Mariantonietta D’Ambrosio, Emiliano Pasquini, Angelica Varesi, Francesca Cogo, Simone Mosole, Cristina Dongilli, Maria Andrea Desbats, Liliana Contu, Ajinkya Revankdar, Jingjing Chen, Madhuri Kalathur, Maria Luna Perciato, Rossella Basilotta, Laczko Endre, Stefan Schauer, Alaa Othman, Ilaria Guccini,
Cellular senescence can exert dual effects in tumors, either suppressing or promoting tumor progression. The senescence-associated secretory phenotype (SASP), released by senescent cells, plays a crucial role in this dichotomy. Consequently, the clinical challenge lies in developing therapies that safely enhance senescence in cancer, favoring tumor-suppressive SASP factors over tumor-promoting ones
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Unleashing a safe and potent pro-senescence anti-tumor strategy Cancer Cell (IF 50.3) Pub Date : 2024-02-29 Shasha Chen, Beicheng Sun, Zhongjun Dong
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PDGFRα+ITGA11+ fibroblasts foster early-stage cancer lymphovascular invasion and lymphatic metastasis via ITGA11-SELE interplay Cancer Cell (IF 50.3) Pub Date : 2024-02-29 Hanhao Zheng, Mingjie An, Yuming Luo, Xiayao Diao, Wenlong Zhong, Mingrui Pang, Yan Lin, Jiancheng Chen, Yuanlong Li, Yao Kong, Yue Zhao, Yina Yin, Le Ai, Jian Huang, Changhao Chen, Tianxin Lin
Cancer-associated fibroblasts (CAFs) exhibit considerable heterogeneity in advanced cancers; however, the functional annotation and mechanism of CAFs in early-stage cancers remain elusive. Utilizing single-cell RNA sequencing and spatial transcriptomic, we identify a previously unknown PDGFRαITGA11 CAF subset in early-stage bladder cancer (BCa). Multicenter clinical analysis of a 910-case cohort confirms
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Multi-omic profiling of follicular lymphoma reveals changes in tissue architecture and enhanced stromal remodeling in high-risk patients Cancer Cell (IF 50.3) Pub Date : 2024-02-29 Andrea J. Radtke, Ekaterina Postovalova, Arina Varlamova, Alexander Bagaev, Maria Sorokina, Olga Kudryashova, Mark Meerson, Margarita Polyakova, Ilia Galkin, Viktor Svekolkin, Sergey Isaev, Daniil Wiebe, Anna Sharun, Alexander Sarachakov, Grigory Perelman, Yaroslav Lozinsky, Ziv Yaniv, Bradley C. Lowekamp, Emily Speranza, Li Yao, Stefania Pittaluga, Arthur L. Shaffer III, Danny Jonigk, James D. Phelan
Follicular lymphoma (FL) is a generally incurable malignancy that evolves from developmentally blocked germinal center (GC) B cells. To promote survival and immune escape, tumor B cells undergo significant genetic changes and extensively remodel the lymphoid microenvironment. Dynamic interactions between tumor B cells and the tumor microenvironment (TME) are hypothesized to contribute to the broad
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Transforming the cardiometabolic disease landscape: Multimodal AI-powered approaches in prevention and management Cell Metab. (IF 29.0) Pub Date : 2024-02-29 Evan D. Muse, Eric J. Topol
The rise of artificial intelligence (AI) has revolutionized various scientific fields, particularly in medicine, where it has enabled the modeling of complex relationships from massive datasets. Initially, AI algorithms focused on improved interpretation of diagnostic studies such as chest X-rays and electrocardiograms in addition to predicting patient outcomes and future disease onset. However, AI
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Structure of the multi-subunit chloroplast RNA polymerase Mol. Cell (IF 16.0) Pub Date : 2024-02-29 Paula F.V. do Prado, Frederik M. Ahrens, Monique Liebers, Noah Ditz, Hans-Peter Braun, Thomas Pfannschmidt, Hauke S. Hillen
Chloroplasts contain a dedicated genome that encodes subunits of the photosynthesis machinery. Transcription of photosynthesis genes is predominantly carried out by a plastid-encoded RNA polymerase (PEP), a nearly 1 MDa complex composed of core subunits with homology to eubacterial RNA polymerases (RNAPs) and at least 12 additional chloroplast-specific PEP-associated proteins (PAPs). However, the architecture
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Triaging of α-helical proteins to the mitochondrial outer membrane by distinct chaperone machinery based on substrate topology Mol. Cell (IF 16.0) Pub Date : 2024-02-29 Gayathri Muthukumar, Taylor A. Stevens, Alison J. Inglis, Theodore K. Esantsi, Reuben A. Saunders, Fabian Schulte, Rebecca M. Voorhees, Alina Guna, Jonathan S. Weissman
Mitochondrial outer membrane ⍺-helical proteins play critical roles in mitochondrial-cytoplasmic communication, but the rules governing the targeting and insertion of these biophysically diverse proteins remain unknown. Here, we first defined the complement of required mammalian biogenesis machinery through genome-wide CRISPRi screens using topologically distinct membrane proteins. Systematic analysis
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Enhancer selectivity in space and time: from enhancer–promoter interactions to promoter activation Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2024-02-27 Jin H. Yang, Anders S. Hansen
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Hypoxia-activated XBP1s recruits HDAC2-EZH2 to engage epigenetic suppression of ΔNp63α expression and promote breast cancer metastasis independent of HIF1α Cell Death Differ. (IF 12.4) Pub Date : 2024-02-27 Hu Chen, Shuhan Yu, Ruidong Ma, Liyuan Deng, Yong Yi, Mengmeng Niu, Chuan Xu, Zhi-Xiong Jim Xiao
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Multimodal detection of molecular residual disease in high-risk locally advanced squamous cell carcinoma of the head and neck Cell Death Differ. (IF 12.4) Pub Date : 2024-02-26 Enrique Sanz-Garcia, Jinfeng Zou, Lisa Avery, Anna Spreafico, John Waldron, David Goldstein, Aaron Hansen, B. C. John Cho, John de Almeida, Andrew Hope, Ali Hosni, Ezra Hahn, Bayardo Perez-Ordonez, Zhen Zhao, Christopher Smith, Yangqiao Zheng, Nitthusha Singaravelan, Scott V. Bratman, Lillian L. Siu
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METTL3 restrains autoimmunity in β-cells Nat. Cell Biol. (IF 21.3) Pub Date : 2024-02-26 Balasubramanian Krishnamurthy, Helen E. Thomas
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Redox regulation of m6A methyltransferase METTL3 in β-cells controls the innate immune response in type 1 diabetes Nat. Cell Biol. (IF 21.3) Pub Date : 2024-02-26 Dario F. De Jesus, Zijie Zhang, Natalie K. Brown, Xiaolu Li, Ling Xiao, Jiang Hu, Matthew J. Gaffrey, Garrett Fogarty, Sevim Kahraman, Jiangbo Wei, Giorgio Basile, Tariq M. Rana, Clayton Mathews, Alvin C. Powers, Audrey V. Parent, Mark A. Atkinson, Sirano Dhe-Paganon, Decio L. Eizirik, Wei-Jun Qian, Chuan He, Rohit N. Kulkarni
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Contractility drives the spatio-temporal coordination of morphogenesis and cell fate in hair follicles Nat. Cell Biol. (IF 21.3) Pub Date : 2024-02-23
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Lessons from infrastructure and research advocacy in India Nat. Cell Biol. (IF 21.3) Pub Date : 2024-02-23 Arun K. Shukla
Scientists must actively advocate for infrastructure development and funding of emerging research directions through collective efforts. In India, this has been crucial to help reverse the brain drain and enable equitable contributions to research and development at the global level.
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Metabolic regulation of chemoresistance and immuno-surveillance in AML by SHP-1 Nat. Cell Biol. (IF 21.3) Pub Date : 2024-02-23
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Lysosomal channels sensing forces Nat. Cell Biol. (IF 21.3) Pub Date : 2024-02-22 Erika Riederer, Dejian Ren
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Drosophila TMEM63 and mouse TMEM63A are lysosomal mechanosensory ion channels Nat. Cell Biol. (IF 21.3) Pub Date : 2024-02-22 Kai Li, Yanmeng Guo, Yayu Wang, Ruijun Zhu, Wei Chen, Tong Cheng, Xiaofan Zhang, Yinjun Jia, Ting Liu, Wei Zhang, Lily Yeh Jan, Yuh Nung Jan
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Exposure of the inner mitochondrial membrane triggers apoptotic mitophagy Cell Death Differ. (IF 12.4) Pub Date : 2024-02-23 Tahnee L. Saunders, Simon P. Windley, Gediminas Gervinskas, Katherine R. Balka, Caitlin Rowe, Rachael Lane, Maximilien Tailler, Thanh Ngoc Nguyen, Georg Ramm, Michael Lazarou, Dominic De Nardo, Benjamin T. Kile, Kate McArthur
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Cold-inducible RNA binding protein alleviates iron overload-induced neural ferroptosis under perinatal hypoxia insult Cell Death Differ. (IF 12.4) Pub Date : 2024-02-22 Xiaozheng Zhu, Ruili Guan, Yuankang Zou, Ming Li, Jingyuan Chen, Jianbin Zhang, Wenjing Luo
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CaSSiDI: novel single-cell “Cluster Similarity Scoring and Distinction Index” reveals critical functions for PirB and context-dependent Cebpb repression Cell Death Differ. (IF 12.4) Pub Date : 2024-02-21 Robert Nechanitzky, Parameswaran Ramachandran, Duygu Nechanitzky, Wanda Y. Li, Andrew C. Wakeham, Jillian Haight, Mary E. Saunders, Slava Epelman, Tak W. Mak
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DUSP4 modulates RIG-I- and STING-mediated IRF3-type I IFN response Cell Death Differ. (IF 12.4) Pub Date : 2024-02-21 Huipeng Jiao, Sharmy J. James, Chin Wen Png, Chaoyu Cui, Heng Li, Liang Li, Wan Ni Chia, Nyo Min, Weiyun Li, Carla Claser, Laurent Rénia, Hongyan Wang, Mark I-Cheng Chen, Justin Jang Hann Chu, Kevin Shyong Wei Tan, Yinyue Deng, Yongliang Zhang
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Gut microbial co-metabolite 2-methylbutyrylcarnitine exacerbates thrombosis via binding to and activating integrin α2β1 Cell Metab. (IF 29.0) Pub Date : 2024-02-23 Kan Huang, Zilun Li, Xi He, Jun Dai, Bingding Huang, Yongxia Shi, Dongxiao Fan, Zefeng Zhang, Yunchong Liu, Na Li, Zhongyu Zhang, Jiangyun Peng, Chenshu Liu, Renli Zeng, Zhipeng Cen, Tengyao Wang, Wenchao Yang, Meifeng Cen, Jingyu Li, Shuai Yuan, Lu Zhang, Dandan Hu, Shuxiang Huang, Pin Chen, Peilong Lai, Liyan Lin, Jielu Wen, Zhengde Zhao, Xiuyi Huang, Lining Yuan, Lifang Zhou, Haoliang Wu, Lihua
Thrombosis represents the leading cause of death and disability upon major adverse cardiovascular events (MACEs). Numerous pathological conditions such as COVID-19 and metabolic disorders can lead to a heightened thrombotic risk; however, the underlying mechanisms remain poorly understood. Our study illustrates that 2-methylbutyrylcarnitine (2MBC), a branched-chain acylcarnitine, is accumulated in
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Distinct negative elongation factor conformations regulate RNA polymerase II promoter-proximal pausing Mol. Cell (IF 16.0) Pub Date : 2024-02-23 Bonnie G. Su, Seychelle M. Vos
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Bidirectional substrate shuttling between the 26S proteasome and the Cdc48 ATPase promotes protein degradation Mol. Cell (IF 16.0) Pub Date : 2024-02-23 Hao Li, Zhejian Ji, Joao A. Paulo, Steven P. Gygi, Tom A. Rapoport
Most eukaryotic proteins are degraded by the 26S proteasome after modification with a polyubiquitin chain. Substrates lacking unstructured segments cannot be degraded directly and require prior unfolding by the Cdc48 ATPase (p97 or VCP in mammals) in complex with its ubiquitin-binding partner Ufd1-Npl4 (UN). Here, we use purified yeast components to reconstitute Cdc48-dependent degradation of well-folded
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Adeno-to-squamous transition drives resistance to KRAS inhibition in LKB1 mutant lung cancer Cancer Cell (IF 50.3) Pub Date : 2024-02-22 Xinyuan Tong, Ayushi S. Patel, Eejung Kim, Hongjun Li, Yueqing Chen, Shuai Li, Shengwu Liu, Julien Dilly, Kevin S. Kapner, Ningxia Zhang, Yun Xue, Laura Hover, Suman Mukhopadhyay, Fiona Sherman, Khrystyna Myndzar, Priyanka Sahu, Yijun Gao, Fei Li, Fuming Li, Zhaoyuan Fang, Yujuan Jin, Juntao Gao, Minglei Shi, Satrajit Sinha, Luonan Chen, Yang Chen, Thian Kheoh, Wenjing Yang, Itai Yanai, Andre L. Moreira
KRAS inhibitors (adagrasib and sotorasib) have shown clinical promise in targeting -mutated lung cancers; however, most patients eventually develop resistance. In lung patients with adenocarcinoma with and / co-mutations, we find an enrichment of the squamous cell carcinoma gene signature in pre-treatment biopsies correlates with a poor response to adagrasib. Studies of -deficient and lung cancer mouse
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Chronic stress increases metastasis via neutrophil-mediated changes to the microenvironment Cancer Cell (IF 50.3) Pub Date : 2024-02-22 Xue-Yan He, Yuan Gao, David Ng, Evdokia Michalopoulou, Shanu George, Jose M. Adrover, Lijuan Sun, Jean Albrengues, Juliane Daßler-Plenker, Xiao Han, Ledong Wan, Xiaoli Sky Wu, Longling S. Shui, Yu-Han Huang, Bodu Liu, Chang Su, David L. Spector, Christopher R. Vakoc, Linda Van Aelst, Mikala Egeblad
Chronic stress is associated with increased risk of metastasis and poor survival in cancer patients, yet the reasons are unclear. We show that chronic stress increases lung metastasis from disseminated cancer cells 2- to 4-fold in mice. Chronic stress significantly alters the lung microenvironment, with fibronectin accumulation, reduced T cell infiltration, and increased neutrophil infiltration. Depleting
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Revisiting TNM staging for EBV-related nasopharyngeal carcinoma Cancer Cell (IF 50.3) Pub Date : 2024-02-22 Michael Dennis, Robert Haddad
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Characterization of the generic mutant p53-rescue compounds in a broad range of assays Cancer Cell (IF 50.3) Pub Date : 2024-02-22 Shujun Xiao, Fangfang Shi, Huaxin Song, Jingyi Cui, Derun Zheng, Hesong Zhang, Kai Tan, Jiaqi Wu, Xueqin Chen, Jiale Wu, Yigang Tang, Yuting Dai, Min Lu