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A postsynaptic GPR158-PLCXD2 complex controls spine apparatus abundance and dendritic spine maturation Dev. Cell (IF 10.7) Pub Date : 2025-05-19 Ben Verpoort, Luísa Amado, Jeroen Vandensteen, Elke Leysen, Dan Dascenco, Joris Vandenbempt, Irma Lemmens, Joris Wauman, Kristel Vennekens, Abril Escamilla-Ayala, Ana Cristina Nogueira Freitas, Thomas Voets, Sebastian Munck, Jan Tavernier, Keimpe Wierda, Joris de Wit
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A kinase cascade drives fast calcium-induced osmotic stress response in plants Dev. Cell (IF 10.7) Pub Date : 2025-05-19 Dietmar Geiger, Rainer Hedrich
The phytohormone abscisic acid (ABA) triggers the activation of Snf1-related protein kinase 2s (SnRK2s) for adaptation to abiotic stress conditions. However, osmotic stress-induced ABA accumulation is slow while Ca2+ signals occur immediately. In this issue of Developmental Cell, Li et al. show that a subset of calcium-dependent kinases decode Ca2+ signals to directly control SnRK2 activation and thus
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Setting up cAMP in plants Dev. Cell (IF 10.7) Pub Date : 2025-05-19 Jason W. Reed
The hormone auxin regulates many aspects of plant growth and development. In a recent issue of Nature, Chen et al. report that an adenylate cyclase activity of auxin receptors promotes auxin-induced transcription activation. This suggests that the second messenger cAMP functions differently in plants than in other organisms.
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Wheat tandem kinase-NLR immune modules: Novel insights and engineering opportunities Dev. Cell (IF 10.7) Pub Date : 2025-05-19 Furong Liu, Brian J. Staskawicz
In a recent issue of Science, Chen et al. and Lu et al. define a wheat immune module comprising tandem kinase (TK)-NLR protein pairs that recognize fungal effectors and activate defense responses. These findings reveal previously unknown immune signaling mechanisms and provide a foundation for engineering disease resistance through molecular breeding.
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Mechanisms of auxin action in plant growth and development Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2025-05-19 Steffen Vanneste, Yuanrong Pei, Jiří Friml
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Neurodevelopmental hijacking of oligodendrocyte lineage programs drives glioblastoma infiltration Dev. Cell (IF 10.7) Pub Date : 2025-05-16 Yiyan Wu, Benson Z. Wu, Yosef Ellenbogen, Joan B.Y. Kant, Pengcheng Yu, Xuyao Li, Loïc Caloren, Valentin Sotov, Christine Tran, Michelle Restrepo, Michelle Kushida, Shamini Ayyadhury, Pathum Kossinna, Ruth Lau, Parnian Habibi, Sheila Mansouri, Johanna Regala, Tanja Durbic, Farzaneh Aboualizadeh, Julissa Tsao, Federico Gaiti
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Acetylated cellulose suppresses body mass gain through gut commensals consuming host-accessible carbohydrates Cell Metab. (IF 27.7) Pub Date : 2025-05-16 Tadashi Takeuchi, Eiji Miyauchi, Yumiko Nakanishi, Yusuke Ito, Tamotsu Kato, Katsuki Yaguchi, Masami Kawasumi, Naoko Tachibana, Ayumi Ito, Shu Shimamoto, Akinobu Matsuyama, Nobuo Sasaki, Ikuo Kimura, Hiroshi Ohno
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Three-way regulation of transcription Nat. Cell Biol. (IF 17.3) Pub Date : 2025-05-15 Sabrya Carim
Phosphorylation regulates the transition between phases of the RNA polymerase II (RNAPII) transcription cycle. The elongation factor SPT5 is phosphorylated by the CDK9 kinase on a flexible linker and in C-terminal repeat 1 (CTR1) to regulate promoter-proximal pausing and termination. In this study, Sun and Fisher report that the C-terminal repeat 2 (CTR2) region in SPT5 is also phosphorylated by CDK9
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Stem cells against Parkinson’s Nat. Cell Biol. (IF 17.3) Pub Date : 2025-05-15 Stylianos Lefkopoulos
Previous studies have developed an approach to derive midbrain dopaminergic neurons from human embryonic stem (hES) cells. Tabar et al. now use these cells in an open, phase 1 clinical trial aiming to treat Parkinson’s disease (PD). The authors primarily assessed the safety and tolerability of bilateral grafts of cryopreserved dopaminergic neuron progenitor cells into the putamen of individuals with
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Stem cells in the clinic Nat. Cell Biol. (IF 17.3) Pub Date : 2025-05-15 Stylianos Lefkopoulos
Treatments that aim to alleviate the symptoms of Parkinson’s disease (PD) are only effective at the early stages and eventually lead to complications. Sawamoto et al. conduct an open-label, phase 1/2 clinical trial to test induced pluripotent stem (iPS) cell-derived dopaminergic cells as a therapeutic approach for PD. The researchers bilaterally transplanted allogeneic iPS cell-derived dopaminergic
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Molecular arms in microbial defense: Argonautes and Cas4 nucleases team up Mol. Cell (IF 14.5) Pub Date : 2025-05-15 Sucharita Sarkar, Ian J. MacRae
In this issue of Molecular Cell, Bobadilla Ugarte et al.1 show that ACE1, a Cas4-family nuclease, partners with prokaryotic Argonautes to generate guide DNAs, revealing a dedicated siDNA biogenesis pathway in cyanobacterial immune systems.
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Global translational regulation by Prkra: Is PKR no longer needed? Mol. Cell (IF 14.5) Pub Date : 2025-05-15 Mihye Lee, Jaemin Jeon, Yoosik Kim
In this issue of Molecular Cell, Lu et al.1 report conserved global translation suppression by Prkra, also known as PACT in humans, in response to double-stranded RNA stimulation. Prkra directly binds to RNA and sequesters eIF2 complexes in a PKR-independent manner.
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Quality control of ribosome assembly: Kinetic discrimination at work Mol. Cell (IF 14.5) Pub Date : 2025-05-15 Yunyang Zhang, Ning Gao
Ribosome biogenesis is a complex and error-prone process, necessitating quality control mechanisms to degrade defective pre-ribosomal intermediates. In this issue of Molecular Cell, Akers et al.1 report the identification of a previously uncharacterized quality control pathway named ribosome assembly surveillance pathway (RASP), which functions to eliminate aberrant "dead-end" pre-60S assembly intermediates
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Proteasome: An antibiotic arsenal in anti-bacterial innate immunity Mol. Cell (IF 14.5) Pub Date : 2025-05-15 Yi Zheng, Chengjiang Gao
The function of the proteasome besides degrading protein remains enigmatic. Goldberg et al. demonstrate that proteasomes can process proteins into antimicrobial peptides (AMPs) to ward off bacterial infection,1 revealing a new function of proteasomes in innate immunity.
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Uracil-induced replication stress drives mutations, genome instability, anti-cancer treatment efficacy, and resistance Mol. Cell (IF 14.5) Pub Date : 2025-05-15 Oliver Mortusewicz, James Haslam, Helge Gad, Thomas Helleday
Uracil incorporation into DNA, as a result of nucleotide pool imbalances or cytosine deamination (e.g., through APOBEC3A/3B), can result in replication stress and is the most common source of mutations in cancer and aging. Despite the critical role of uracil in genome instability, cancer development, and cancer therapy, only now is there emerging data on its impact on fundamental processes such as
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Regulation of RNA polymerase II transcription through re-initiation and bursting Mol. Cell (IF 14.5) Pub Date : 2025-05-15 Michael Nagel, Dylan J. Taatjes
The regulation of RNA polymerase II (RNAPII) activity requires orchestrated responses among genomic regulatory sequences and an expansive set of proteins and protein complexes. Despite intense study over five decades, mechanistic insights continue to emerge. Within the past 10 years, live-cell imaging and single-cell transcriptomics experiments have yielded new information about enhancer-promoter communication
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U1 snRNP regulates alternative promoter activity by inhibiting premature polyadenylation Mol. Cell (IF 14.5) Pub Date : 2025-05-15 GyeungYun Kim, Christine L. Carroll, Zachary Peters Wakefield, Mustafa Tuncay, Ana Fiszbein
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Ribosomes modulate transcriptome abundance via generalized frameshift and out-of-frame mRNA decay Mol. Cell (IF 14.5) Pub Date : 2025-05-15 Yujie Zhang, Lilit Nersisyan, Eliska Fürst, Ioannis Alexopoulos, Carlos Santolaria, Susanne Huch, Claudio Bassot, Elena Garre, Per Sunnerhagen, Ilaria Piazza, Vicent Pelechano
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Hydrogen peroxide in midbrain sleep neurons regulates sleep homeostasis Cell Metab. (IF 27.7) Pub Date : 2025-05-15 Yujing Tian, Luwei Kang, Ngoc T. Ha, Juan Deng, Danqian Liu
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Genetic modeling of ELP1-associated Sonic hedgehog medulloblastoma identifies MDM2 as a selective therapeutic target Cancer Cell (IF 48.8) Pub Date : 2025-05-15 Shiekh Tanveer Ahmad, Yiran Li, Jesus Garcia-Lopez, Brian L. Gudenas, Jennifer Hadley, Leena Paul, Stephanie C. Wu, Alaa Refaat, Marija Kojic, Melissa Batts, Taha Soliman, Aaron Pitre, Frederik Arnskötter, Frederique Zindy, Alun Jones, Nathaniel R. Twarog, Anand Mayasundari, Brandon Bianski, Christopher Tinkle, Abbas Shirinifard, Paul A. Northcott
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Isocitrate dehydrogenase 1 primes group-3 medulloblastomas for cuproptosis Cancer Cell (IF 48.8) Pub Date : 2025-05-15 Derek Dang, Akash Deogharkar, John McKolay, Kyle S. Smith, Pooja Panwalkar, Simon Hoffman, Wentao Tian, Sunjong Ji, Ana P. Azambuja, Siva Kumar Natarajan, Joanna Lum, Jill Bayliss, Katie Manzeck, Stefan R. Sweha, Erin Hamanishi, Matthew Pun, Diya Patel, Sagar Rau, Olamide Animasahun, Abhinav Achreja, Sriram Venneti
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Molecular machineries shaping the mitochondrial inner membrane Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2025-05-14 Oliver Daumke, Martin van der Laan
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Cockayne syndrome mice reflect human kidney disease and are defective in de novo NAD biosynthesis Cell Death Differ. (IF 13.7) Pub Date : 2025-05-15 Komal Pekhale, Vinod Tiwari, Mansoor Hussain, Christy C. Bridges, Deborah L. Croteau, Moshe Levi, Avi Z. Rosenberg, Briana Santo, Xiaoping Yang, Tomasz Kulikowicz, Xiaoxin X. Wang, Jong-Hyuk Lee, Vilhelm A. Bohr
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ARID1A loss enhances sensitivity to c-MET inhibition by dual targeting of GPX4 and iron homeostasis, inducing ferroptosis Cell Death Differ. (IF 13.7) Pub Date : 2025-05-14 Xu Zhang, Zihuan Wang, Yilin He, Kejin Wang, Cheng Xiang, Yongfeng Liu, Yijiang Song, Aimin Li, Zhen Wang, Yingnan Yu, Wenxuan Peng, Side Liu, Joong Sup Shim, Changjie Wu
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Fatty acid synthesis promotes mtDNA release via ETS1-mediated oligomerization of VDAC1 facilitating endothelial dysfunction in sepsis-induced lung injury Cell Death Differ. (IF 13.7) Pub Date : 2025-05-14 Shiyuan He, Tingting Pan, Rui Tian, Qian He, Decui Cheng, Hongping Qu, Ranran Li, Ruoming Tan
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Good things come in threes: Distinct C. elegans basement membranes utilize novel collagen IV trimers. J. Cell Biol. (IF 7.4) Pub Date : 2025-05-15 K Elkie Peebles,Andrea Page-McCaw
The highly conserved basement membrane protein collagen IV is stereotypically composed of two α1 subunits and one α2 subunit. In this issue, Srinivasan et al. (https://doi.org/10.1083/jcb.202412118) show that specific C. elegans basement membranes include collagen IV trimers with other compositions, suggesting a new diversity.
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A virulence protein activates SERK4 and degrades RNA polymerase IV protein to suppress rice antiviral immunity Dev. Cell (IF 10.7) Pub Date : 2025-05-14 Yuansheng Wu, Shanshan Zhao, Na Liu, Fengling Wu, Shiting Huang, Dongyuan Li, Baiyang Li, Yutong Miao, Hongxin Guan, Ming Wu, Shuai Zhang, Yi Li, Jie Zhang, Jianguo Wu
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Hepatic lipid remodeling in cold exposure uncovers direct regulation of bis(monoacylglycero)phosphate lipids by phospholipase A2 group XV Cell Metab. (IF 27.7) Pub Date : 2025-05-14 Jessica W. Davidson, Raghav Jain, Thomas Kizzar, Gisela Geoghegan, Daniel J. Nesbitt, Amy Cavanagh, Akira Abe, Kwamina Nyame, Andrea Hunger, Xiaojuan Chao, Isabella James, Helaina Walesewicz, Dominique A. Baldwin, Gina Wade, Sylwia Michorowska, Rakesh Verma, Kathryn Schueler, Vania Hinkovska-Galcheva, Evgenia Shishkova, Wen-Xing Ding, Judith A. Simcox
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Establishing dorsal-ventral patterning in human neural tube organoids with synthetic organizers Cell Stem Cell (IF 19.8) Pub Date : 2025-05-14 Tao Luo, Cong Liu, Tao Cheng, Guo-Qin Zhao, Ying Huang, Jing-Yun Luan, Junyu Guo, Xiang Liu, Yi-Fan Wang, Yang Dong, Yu Xiao, Enhui He, Rui-Zhen Sun, Xiuyu Chen, Jiekai Chen, Jun Ma, Sean Megason, Junfeng Ji, Peng-Fei Xu
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RING1 dictates GSDMD-mediated inflammatory response and host susceptibility to pathogen infection Cell Death Differ. (IF 13.7) Pub Date : 2025-05-14 Yuanyuan Li, Wenqing Gao, Yuxin Qiu, Jiasong Pan, Qingqing Guo, Xuehe Liu, Lu Geng, Yajie Shen, Yifan Deng, Zhidong Hu, Suhua Li, Shanshan Liu, Adi Idris, Jinqing Huang, Hua Yang, Baoxue Ge, Xiaoyong Fan, Xiangjun Chen, Jixi Li
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Genomic evolution reshapes cell-type diversification in the amniote brain Dev. Cell (IF 10.7) Pub Date : 2025-05-13 Duoyuan Chen, Zhenkun Zhuang, Maolin Huang, Yunqi Huang, Yuting Yan, Yanru Zhang, Youning Lin, Xiaoying Jin, Yuanmei Wang, Jinfeng Huang, Wenbo Xu, Jingfang Pan, Hong Wang, Fubaoqian Huang, Kuo Liao, Mengnan Cheng, Zhiyong Zhu, Yinqi Bai, Zhiwei Niu, Ze Zhang, Shiping Liu
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Histone H1 deamidation regulates DNA double-strand break repair Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2025-05-13 Caroline Barranco
Repair of DNA double-strand breaks requires chromatin opening; however, the mechanisms involved were unclear. This work shows that sequential histone deamidation and acetylation modifications induce chromatin decompaction by reducing positive charge at the DNA–nucleosome interface.
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Fat accumulation in middle-aged male animals Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2025-05-13 Kim Baumann
A distinct population of adipose progenitor cells contributes to the accumulation of visceral white adipose tissue in middle-aged male mice.
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FGF21 reverses MASH through coordinated actions on the CNS and liver Cell Metab. (IF 27.7) Pub Date : 2025-05-13 Jesse P. Rose, Donald A. Morgan, Andrew I. Sullivan, Xiaorong Fu, Melissa Inigo-Vollmer, Shawn C. Burgess, David K. Meyerholz, Kamal Rahmouni, Matthew J. Potthoff
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The mitophagy receptors BNIP3 and NIX mediate tight attachment and expansion of the isolation membrane to mitochondria. J. Cell Biol. (IF 7.4) Pub Date : 2025-05-13 Shun-Ichi Yamashita,Ritsuko Arai,Hiroshi Hada,Benjamin Scott Padman,Michael Lazarou,David C Chan,Tomotake Kanki,Satoshi Waguri
BNIP3 and NIX are the main receptors for mitophagy, but their mechanisms of action remain elusive. Here, we used correlative light EM (CLEM) and electron tomography to reveal the tight attachment of isolation membranes (IMs) to mitochondrial protrusions, often connected with ER via thin tubular and/or linear structures. In BNIP3/NIX-double knockout (DKO) HeLa cells, the ULK1 complex and nascent IM
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Atg9 is a conserved regulator of lysosome repair. J. Cell Biol. (IF 7.4) Pub Date : 2025-05-13 Ruoxi Wang,Eric H Baehrecke
The ATG9 transmembrane protein scrambles lipids to regulate phagophore formation during autophagy. Two recent studies from Peng et al. (https://doi.org/10.1083/jcb.202411092) and De Tito et al. (https://doi.org/10.1101/2024.07.23.604321) identify ATG9 as a conserved regulator of lysosome repair in Caenorhabditis elegans and human cells, but differences in repair mechanisms exist between these taxa
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Stromal barriers to the abscopal effect Cancer Cell (IF 48.8) Pub Date : 2025-05-12 Tian V. Tian, Silvia Affò
In this issue of Cancer Cell, Zhang et al. reveal that PAI-1-induced SFRP2high cancer-associated fibroblasts reduce the abscopal effect of radioimmunotherapy. Targeting PAI-1 or SFRP2 enhances T cell recruitment and prevents the formation of an immunosuppressive perivascular niche, improving radioimmunotherapy’s abscopal effect.
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Acquired semi-squamatization during chemotherapy suggests differentiation as a therapeutic strategy for bladder cancer Cancer Cell (IF 48.8) Pub Date : 2025-05-12 Manli Wang, Xuelan Chen, Ping Tan, Yiyun Wang, Xiangyu Pan, Tianhai Lin, Yong Jiang, Bo Wang, Huan Xu, Yuying Wang, Yucen Yang, Jian Wang, Lei Zhao, Jiapeng Zhang, Ailing Zhong, Yiman Peng, Jiajia Du, Qi Zhang, Jianan Zheng, Jingyao Chen, Chong Chen
(Cancer Cell 40, 1044–1059.e1–e8; September 12, 2022)
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Endothelial CCR2 Signaling Induced by Colon Carcinoma Cells Enables Extravasation via the JAK2-Stat5 and p38MAPK Pathway Cancer Cell (IF 48.8) Pub Date : 2025-05-12 Monika Julia Wolf, Alexandra Hoos, Judith Bauer, Steffen Boettcher, Markus Knust, Achim Weber, Nicole Simonavicius, Christoph Schneider, Matthias Lang, Michael Stürzl, Roland S. Croner, Andreas Konrad, Markus G. Manz, Holger Moch, Adriano Aguzzi, Geert van Loo, Manolis Pasparakis, Marco Prinz, Lubor Borsig, Mathias Heikenwalder
(Cancer Cell 22, 91–105; July 10, 2012)
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Uncovering the complexity of RNA–protein interactions Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2025-05-12 Maïwen Caudron-Herger
A 2012 study discovered that RNA–binding proteins are more numerous and diverse than previously thought, many having non-canonical RNA-binding domains.
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ALDH4A1 functions as an active component of the MPC complex maintaining mitochondrial pyruvate import for TCA cycle entry and tumour suppression Nat. Cell Biol. (IF 17.3) Pub Date : 2025-05-12 Che-Chia Hsu, Chi-Yun Wang, Rajesh Kumar Manne, Zhen Cai, Vasudevarao Penugurti, Rajni Kant, Ling Bai, Bo-Syong Pan, Tingjin Chen, Yuan-Ru Chen, Hsin-En Wu, Yan Jin, Haiwei Gu, Chia-Yang Li, Hui-Kuan Lin
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Anillin links up with RhoA to break the symmetry of cytokinetic ring closure. J. Cell Biol. (IF 7.4) Pub Date : 2025-05-12 Guillaume D Chambaud,Vlad C Martin,Gilles R X Hickson
During animal cell cytokinesis, active RhoA assembles actomyosin-based contractile rings that tend to close asymmetrically. Through imaging C. elegans zygotes, Lebedev et al. (https://doi.org/10.1083/jcb.202405182) reveal that the scaffold protein, anillin, promotes asymmetric ring closure by locally sequestering RhoA from its canonical effectors and thereby limiting actomyosin contractility.
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KIF2A stabilizes intercellular bridge microtubules to maintain mouse embryonic stem cell cytokinesis. J. Cell Biol. (IF 7.4) Pub Date : 2025-05-12 Lieke Stockmann,Hélène Kabbech,Gert-Jan Kremers,Brent van Herk,Bas Dille,Mirjam van den Hout,Wilfred F J van IJcken,Dick H W Dekkers,Jeroen A A Demmers,Ihor Smal,Danny Huylebroeck,Sreya Basu,Niels Galjart
Cytokinesis, the final stage of cell division, serves to physically separate daughter cells. In cultured naïve mouse embryonic stem cells, cytokinesis lasts unusually long. Here, we describe a novel function for the kinesin-13 member KIF2A in this process. In genome-engineered mouse embryonic stem cells, we find that KIF2A localizes to spindle poles during metaphase and regulates spindle length in
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RIM and MUNC13 membrane-binding domains are essential for neuropeptide secretion. J. Cell Biol. (IF 7.4) Pub Date : 2025-05-12 Fiona H Murphy,Adlin Abramian,Remco V Klaassen,Frank Koopmans,Claudia M Persoon,August B Smit,Ruud F Toonen,Matthijs Verhage
Neurons release neurotransmitters from synaptic vesicles (SVs) and neuropeptides from dense-core vesicles (DCVs). The presynaptic proteins RIM and MUNC13 play key roles in both pathways. It remains unclear how DCVs are targeted to release sites and whether RIM and MUNC13 are involved in this process. Here, we show that three membrane-binding domains in RIM and MUNC13 regulate DCV exocytosis differently
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Focal Adhesion Kinase Is Required for Intestinal Regeneration and Tumorigenesis Downstream of Wnt/c-Myc Signaling Dev. Cell (IF 10.7) Pub Date : 2025-05-10 Gabrielle H. Ashton, Jennifer P. Morton, Kevin Myant, Toby J. Phesse, Rachel A. Ridgway, Victoria Marsh, Julie A. Wilkins, Dimitris Athineos, Vanesa Muncan, Richard Kemp, Kristi Neufeld, Hans Clevers, Valerie Brunton, Douglas J. Winton, Xiaoyan Wang, Rosalie C. Sears, Alan R. Clarke, Margaret C. Frame, Owen J. Sansom
(Developmental Cell 19, 259–269; August 17, 2010)
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Vaccination-based immunotherapy to target profibrotic cells in liver and lung Cell Stem Cell (IF 19.8) Pub Date : 2025-05-10 Michal Sobecki, Jing Chen, Ewelina Krzywinska, Shunmugam Nagarajan, Zheng Fan, Eric Nelius, Josep M. Monné Rodriguez, Frauke Seehusen, Amro Hussein, Greta Moschini, Edries Y. Hajam, Ravi Kiran, Dagmar Gotthardt, Julien Debbache, Cécile Badoual, Tatsuyuki Sato, Takayuki Isagawa, Norihiko Takeda, Corinne Tanchot, Eric Tartour, Christian Stockmann
(Cell Stem Cell 29, 1459–1474.e1–e9; October 6, 2022)
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Differential tissue deformability underlies fluid pressure-driven shape divergence of the avian embryonic brain and spinal cord Dev. Cell (IF 10.7) Pub Date : 2025-05-09 Susannah B.P. McLaren, Shi-Lei Xue, Siyuan Ding, Alexander K. Winkel, Oscar Baldwin, Shreya Dwarakacherla, Kristian Franze, Edouard Hannezo, Fengzhu Xiong
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Single-cell MultiOmics and spatial transcriptomics demonstrate neuroblastoma developmental plasticity Dev. Cell (IF 10.7) Pub Date : 2025-05-09 Yunyun Xu, Daohua Lou, Ping Chen, Gang Li, Dimtry Usoskin, Jian Pan, Fang Li, Shungen Huang, Caroline Hess, Ruze Tang, Xiaohan Hu, Juanjuan Yu, Maria Arceo, Ronald R. de Krijger, Arthur S. Tischler, Susanne Schlisio, Patrik Ernfors, Yizhou Hu, Jian Wang
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Regulation of RIG-I activity by phase separation reveals new therapeutic opportunities Nat. Cell Biol. (IF 17.3) Pub Date : 2025-05-09
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Import mechanism of peroxisomal proteins with an N-terminal signal sequence Nat. Cell Biol. (IF 17.3) Pub Date : 2025-05-09 Michael L. Skowyra, Tom A. Rapoport
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Ubiquitin-SUMO tag-team wrestles acute promyelocytic leukemia. J. Cell Biol. (IF 7.4) Pub Date : 2025-05-09 Alfred C O Vertegaal
In this issue, Jaffray and colleagues (https://doi.org/10.1083/jcb.202407133) detail the molecular machinery required to degrade the oncogene PML in response to arsenic treatment. Different posttranslational modifiers team up: ubiquitin, SUMO1, and -2/3, linked by the SUMO-targeted ubiquitin ligases TOPORS and RNF4.
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The foam cell-derived exosomes exacerbate ischemic white matter injury via transmitting metabolic defects to microglia Cell Metab. (IF 27.7) Pub Date : 2025-05-08 Hang Zhang, Luo-Qi Zhou, Sheng Yang, Ming-Hao Dong, Lian Chen, Yi-Lin Lu, Lu-Yang Zhang, Lan Zhang, Yun-Hui Chu, Lu-Lu Xu, Xiao-Wei Pang, Li-Fang Zhu, Ting Xu, Tu-ying Yong, Wei Wang, Dai-Shi Tian, Chuan Qin
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3D reconstruction of a human Carnegie stage 9 embryo provides a snapshot of early body plan formation Cell Stem Cell (IF 19.8) Pub Date : 2025-05-08 Yang Yuan, Xiaoyan Wang, Xiaodi Yan, Nannan He, Xiaojian Lu, Jingyu Yang, Xinwei Xie, Huiyao Yuan, Naixin Chen, Yinbo Liu, Hongan Ren, Runzhao Zhang, Lina Cui, Pengcheng Ren, Sirui Lin, Shuhan Cheng, Xiaolong Yang, Yifei Guo, Rong Li, Tianyi Yan, Leqian Yu
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Immune evolution in pre-invasive lung adenocarcinoma Cancer Cell (IF 48.8) Pub Date : 2025-05-08 Adithya Balasubramanian, Marie-Liesse Asselin-Labat
The mechanisms governing the progression of precursor lesions to invasive lung adenocarcinoma (LUAD) remain poorly understood. In this issue of Cancer Cell, Zhu et al. map the dynamic immune changes associated with this progression using high-resolution spatial mapping. Their identification of TIM-3 as a potential target may shift strategies for LUAD immunoprevention.
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Immunosequencing identifies signatures of T cell responses for early detection of nasopharyngeal carcinoma Cancer Cell (IF 48.8) Pub Date : 2025-05-08 Shanshan Zhang, Yan Zhou, Zhonghua Liu, Yuqian Wang, Xiang Zhou, Haiwen Chen, Xinyu Zhang, Yanhong Chen, Qisheng Feng, Xiaoping Ye, Shanghang Xie, Mu-Sheng Zeng, Weiwei Zhai, Yi-Xin Zeng, Sumei Cao, Guideng Li, Miao Xu
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Understanding and reversing mammary tumor-driven reprogramming of myelopoiesis to reduce metastatic spread Cancer Cell (IF 48.8) Pub Date : 2025-05-08 Hannah Garner, Moreno Martinovic, Ning Qing Liu, Noor A.M. Bakker, Irene Querol Velilla, Cheei-Sing Hau, Kim Vrijland, Daphne Kaldenbach, Marleen Kok, Elzo de Wit, Karin E. de Visser
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Regulating the fate of tumor-associated macrophages Cancer Cell (IF 48.8) Pub Date : 2025-05-08 Elina Timosenko, Dmitry I. Gabrilovich
Tumor-associated macrophages (TAMs) are key players in tumor progression, yet their role in this process remains only partially understood. In this issue of Cancer Cell, Sheban et al. demonstrate that zinc finger E-box-binding homeobox 2 (ZEB2) acts as a master regulator that reprograms TAMs toward a pro-tumor phenotype and that therapeutic targeting of ZEB2 exhibits anti-tumor activity.
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Brain metastasis: From etiology to ecotypes Cancer Cell (IF 48.8) Pub Date : 2025-05-08 Michael Schulz, Marco Prinz
Despite recent advances in anti-cancer therapies, metastasis, especially to the brain, represents a major clinical challenge with rising incidences. In this issue of Cancer Cell, Xing et al. present a comprehensive transcriptomic map of the metastatic brain tumor environment at single-cell resolution.
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Development and validation of a high-throughput screening pipeline of compound libraries to target EMT Cell Death Differ. (IF 13.7) Pub Date : 2025-05-08 Sven Jonckheere, Joachim Taminau, Jamie Adams, Jef Haerinck, Jordy De Coninck, Jeroen Verstappe, Kato De Clercq, Evelien Peeters, Alexander Gheldof, Eva De Smedt, Vera Goossens, Dominique Audenaert, Aurélie Candi, Matthias Versele, Dominic De Groote, Hanne Verschuere, Marc Stemmler, Thomas Brabletz, Peter Vandenabeele, Andreu Casali, Kyra Campbell, Steven Goossens, Geert Berx
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Spatial and multiomics analysis of human and mouse lung adenocarcinoma precursors reveals TIM-3 as a putative target for precancer interception Cancer Cell (IF 48.8) Pub Date : 2025-05-08 Bo Zhu, Pingjun Chen, Muhammad Aminu, Jian-Rong Li, Junya Fujimoto, Yanhua Tian, Lingzhi Hong, Hong Chen, Xin Hu, Chenyang Li, Natalie Vokes, Andre L. Moreira, Don L. Gibbons, Luisa M. Solis Soto, Edwin Roger Parra Cuentas, Ou Shi, Songhui Diao, Jie Ye, Frank R. Rojas, Eduardo Vilar, Anirban Maitra, Ken Chen, Nicolas Navin, Monique Nilsson, Beibei Huang, Simon Heeke, Jianhua Zhang, Cara L. Haymaker