In a recent article in Cell, Zhou et al. investigate the origins, composition, and biological consequences of UV-induced stress granules. They find that UV-induced stress granules are triggered by the formation of RNA-protein crosslinks, uniquely contain DHX9 as a marker, form during mitosis independently of translation repression, and are enriched in intron-containing RNAs and splicing factors. Moreover, UV-induced granules contain double-stranded RNA (dsRNA) and trigger a dsRNA response. This work identifies a mechanism for resolving UV-damaged RNA and broadens the types of cytosolic "stress granules" that form.

在最近发表在《细胞》杂志上的一篇文章中，Zhou 等人。研究紫外线引起的应激颗粒的起源、组成和生物学后果。他们发现，紫外线诱导的应激颗粒是由 RNA-蛋白质交联的形成触发的，独特地含有 DHX9 作为标记，在有丝分裂期间形成，与翻译抑制无关，并且富含含有内含子的 RNA 和剪接因子。此外，紫外线诱导的颗粒含有双链 RNA (dsRNA) 并触发 dsRNA 反应。这项工作确定了一种解决紫外线损伤 RNA 的机制，并扩大了形成的胞质“应激颗粒”的类型。