-
HBO1 functions as an epigenetic barrier to hepatocyte plasticity and reprogramming during liver injury Cell Stem Cell (IF 19.8) Pub Date : 2025-05-21 Wei-Chien Yuan, Andrew S. Earl, Sai Ma, Karel Alcedo, Jacquelyn O. Russell, Fabiana M. Duarte, Yen-Ting Chu, Pei-Chi Chang, Hsin-Yi Chen, Hsin-Hui Chi, Qian Zhu, Alejo E. Rodriguez-Fraticelli, Sachin H. Patel, Yu-Ru Lee, Jason D. Buenrostro, Fernando D. Camargo
-
Establishing dorsal-ventral patterning in human neural tube organoids with synthetic organizers Cell Stem Cell (IF 19.8) Pub Date : 2025-05-14 Tao Luo, Cong Liu, Tao Cheng, Guo-Qin Zhao, Ying Huang, Jing-Yun Luan, Junyu Guo, Xiang Liu, Yi-Fan Wang, Yang Dong, Yu Xiao, Enhui He, Rui-Zhen Sun, Xiuyu Chen, Jiekai Chen, Jun Ma, Sean Megason, Junfeng Ji, Peng-Fei Xu
-
Vaccination-based immunotherapy to target profibrotic cells in liver and lung Cell Stem Cell (IF 19.8) Pub Date : 2025-05-10 Michal Sobecki, Jing Chen, Ewelina Krzywinska, Shunmugam Nagarajan, Zheng Fan, Eric Nelius, Josep M. Monné Rodriguez, Frauke Seehusen, Amro Hussein, Greta Moschini, Edries Y. Hajam, Ravi Kiran, Dagmar Gotthardt, Julien Debbache, Cécile Badoual, Tatsuyuki Sato, Takayuki Isagawa, Norihiko Takeda, Corinne Tanchot, Eric Tartour, Christian Stockmann
(Cell Stem Cell 29, 1459–1474.e1–e9; October 6, 2022)
-
3D reconstruction of a human Carnegie stage 9 embryo provides a snapshot of early body plan formation Cell Stem Cell (IF 19.8) Pub Date : 2025-05-08 Yang Yuan, Xiaoyan Wang, Xiaodi Yan, Nannan He, Xiaojian Lu, Jingyu Yang, Xinwei Xie, Huiyao Yuan, Naixin Chen, Yinbo Liu, Hongan Ren, Runzhao Zhang, Lina Cui, Pengcheng Ren, Sirui Lin, Shuhan Cheng, Xiaolong Yang, Yifei Guo, Rong Li, Tianyi Yan, Leqian Yu
-
Integrating collecting systems in human kidney organoids through fusion of distal nephron to ureteric bud Cell Stem Cell (IF 19.8) Pub Date : 2025-05-08 Min Shi, Brittney Crouse, Nambirajan Sundaram, Naomi Pode Shakked, Konrad Thorner, Nathaniel M. King, Parna Dutta, Lioba Ester, Weitao Zhang, Vinothini Govindarajah, Raphael Kopan, Cristina Cebrian, Christopher N. Mayhew, Michael A. Helmrath, Joseph V. Bonventre, Kyle W. McCracken
-
Specification of human brain regions with orthogonal gradients of WNT and SHH in organoids reveals patterning variations across cell lines Cell Stem Cell (IF 19.8) Pub Date : 2025-05-01 Soraya Scuderi, Tae-Yun Kang, Alexandre Jourdon, Alex Nelson, Liang Yang, Feinan Wu, George M. Anderson, Jessica Mariani, Livia Tomasini, Vivekananda Sarangi, Alexej Abyzov, Andre Levchenko, Flora M. Vaccarino
-
IRF6 hits the sweet spot Cell Stem Cell (IF 19.8) Pub Date : 2025-05-01 Jane Reznick, Carien M. Niessen
Glucose serves as an essential energy source for cells. In this issue, Lopez-Pajares et al.1 uncover a role for glucose uncoupled from its energetic function. During epidermal differentiation, free glucose accumulates and binds the pro-differentiation transcription factor IRF6, promoting its dimerization and DNA binding to activate genes that drive differentiation.
-
Signaling switches: Metabolism regulates gastruloid self-organization Cell Stem Cell (IF 19.8) Pub Date : 2025-05-01 María J. Rodríguez Colman, Katharina F. Sonnen
Metabolic regulation of embryonic development is increasingly recognized. Villaronga-Luque et al.1 and Stapornwongkul et al.2 show that metabolic activity influences gastruloid formation from mouse embryonic stem cells, revealing that the balance between glycolysis and oxidative phosphorylation regulates cell fate decisions during gastruloid self-organization.
-
Dopaminergic neurons entering the brain under the immunological cover of darkness Cell Stem Cell (IF 19.8) Pub Date : 2025-05-01 Timothy Chai, Julie Y. Chen, Kyle M. Loh
The ability to transplant immunologically foreign cells into an animal without immune suppression would be transformative. Pavan et al. show that human pluripotent stem cell-derived dopaminergic neuron progenitors engineered to express eight immune-evasive proteins can engraft in humanized mice and a rat model of Parkinson’s disease without recourse to immune suppression.1
-
Shaping intestinal organoids: Engineering crypt curvature to guide stem cell niches Cell Stem Cell (IF 19.8) Pub Date : 2025-05-01 Riccardo Barrile, Magdalena Kasendra
Yavitt et al.1 introduce a photodegradable hydrogel platform to control crypt curvature in intestinal organoids, revealing how epithelial morphology directs Paneth cell localization. This innovative approach advances organoid engineering, providing a reproducible method to study stem cell niche interactions and model intestinal development and disease.
-
Roger A. Pedersen (1944–2025) Cell Stem Cell (IF 19.8) Pub Date : 2025-05-01 Victoria L. Mascetti
Download: Download high-res image (228KB) Download: Download full-size image Roger A. Pedersen
-
Litigation of unlicensed US stem cell products Cell Stem Cell (IF 19.8) Pub Date : 2025-05-01 Branden Lee, Noah Brookes, Adam S. Levin
Financial dispositions against unapproved stem cell interventions have grown significantly, with successful class-action lawsuits, malpractice claims, and collaborative prosecutions between government agencies. In addition to improved dispositions, federal circuit courts have given unanimous affirmation to the FDA’s regulatory authority over stem cell interventions, establishing critical precedents
-
Bioengineering innovations for neural organoids with enhanced fidelity and function Cell Stem Cell (IF 19.8) Pub Date : 2025-05-01 Yubing Sun, Yoshiho Ikeuchi, Feng Guo, Insoo Hyun, Guo-li Ming, Jianping Fu
Neural organoids have been utilized to recapitulate different aspects of the developing nervous system. While hailed as promising experimental tools for studying human neural development and neuropathology, current neural organoids do not fully recapitulate the anatomy or microcircuitry-level functionality of the developing brain, spinal cord, or peripheral nervous system. In this review, we discuss
-
Induction of Multipotential Hematopoietic Progenitors from Human Pluripotent Stem Cells via Respecification of Lineage-Restricted Precursors Cell Stem Cell (IF 19.8) Pub Date : 2025-04-29 Sergei Doulatov, Linda T. Vo, Stephanie S. Chou, Peter G. Kim, Natasha Arora, Hu Li, Brandon K. Hadland, Irwin D. Bernstein, James J. Collins, Leonard I. Zon, George Q. Daley
(Cell Stem Cell 13, 459–470; October 3, 2013)
-
Glycolytic activity instructs germ layer proportions through regulation of Nodal and Wnt signaling Cell Stem Cell (IF 19.8) Pub Date : 2025-04-16 Kristina S. Stapornwongkul, Elisa Hahn, Patryk Poliński, Laura Salamó Palau, Krisztina Arató, LiAng Yao, Kate Williamson, Nicola Gritti, Kerim Anlas, Mireia Osuna Lopez, Kiran R. Patil, Idse Heemskerk, Miki Ebisuya, Vikas Trivedi
-
Integrated molecular-phenotypic profiling reveals metabolic control of morphological variation in a stem-cell-based embryo model Cell Stem Cell (IF 19.8) Pub Date : 2025-04-16 Alba Villaronga-Luque, Ryan G. Savill, Natalia López-Anguita, Adriano Bolondi, Sumit Garai, Seher Ipek Gassaloglu, Roua Rouatbi, Kathrin Schmeisser, Aayush Poddar, Lisa Bauer, Tiago Alves, Sofia Traikov, Jonathan Rodenfels, Triantafyllos Chavakis, Aydan Bulut-Karslioglu, Jesse V. Veenvliet
-
Harnessing human iPSC-microglia for CNS-wide delivery of disease-modifying proteins Cell Stem Cell (IF 19.8) Pub Date : 2025-04-14 Jean Paul Chadarevian, Hayk Davtyan, Alina L. Chadarevian, Jasmine Nguyen, Joia K. Capocchi, Lauren Le, Adrian Escobar, Talar Chadarevian, Kimiya Mansour, Ekaterina Deynega, Michael Mgerian, Christina Tu, Sepideh Kiani Shabestari, William Carlen-Jones, Ghazaleh Eskandari-Sedighi, Jonathan Hasselmann, Robert C. Spitale, Mathew Blurton-Jones
-
An erythroid-biased FOShi hematopoietic multipotent progenitor subpopulation contributes to adaptation to chronic hypoxia Cell Stem Cell (IF 19.8) Pub Date : 2025-04-11 Weili Liu, Xiaoru Zhang, Jinhua Liu, Lingling Pu, Lanlan Ai, Hongbao Xu, Guangrui Wang, Ding Wang, Xiaona Song, Yingnan Zhang, Ling Zhang, Jie Gao, Xiaoling Cheng, Xinxing Wang, Jingyuan Tong, Xiaowei Xie, Fang Dong, Yingchi Zhang, Ping Zhu, Zhaoli Chen, Lihong Shi
-
Activating innate immune responses repolarizes hPSC-derived CAR macrophages to improve anti-tumor activity Cell Stem Cell (IF 19.8) Pub Date : 2025-04-11 Jun Shen, Shuzhen Lyu, Yingxi Xu, Shuo Zhang, Li Li, Jinze Li, Junli Mou, Leling Xie, Kejing Tang, Wei Wen, Xuemei Peng, Ying Yang, Yu Shi, Xinjie Li, Min Wang, Xin Li, Jianxiang Wang, Tao Cheng
(Cell Stem Cell 31, 1003–1019.e1–e9; July 5, 2024)
-
A cloaked human stem-cell-derived neural graft capable of functional integration and immune evasion in rodent models Cell Stem Cell (IF 19.8) Pub Date : 2025-04-09 Chiara Pavan, Kathryn C. Davidson, Natalie Payne, Stefano Frausin, Cameron P.J. Hunt, Niamh Moriarty, Miguel Á. Berrocal Rubio, Zahra Elahi, Andrew T. Quattrocchi, Kwaku Dad Abu-Bonsrah, Le Wang, William Clow, Huijuan Yang, Marc Pellegrini, Christine A. Wells, Lachlan H. Thompson, Andras Nagy, Clare L. Parish
-
Intestinal secretory differentiation reflects niche-driven phenotypic and epigenetic plasticity of a common signal-responsive terminal cell Cell Stem Cell (IF 19.8) Pub Date : 2025-04-08 Swarnabh Bhattacharya, Guodong Tie, Pratik N.P. Singh, Ermanno Malagola, Onur Eskiocak, Ruiyang He, Judith Kraiczy, Wei Gu, Yakov Perlov, Aybuke Alici-Garipcan, Semir Beyaz, Timothy C. Wang, Qiao Zhou, Ramesh A. Shivdasani
-
The clones have STRACK: Tracing responses to leukemic mutations Cell Stem Cell (IF 19.8) Pub Date : 2025-04-03 Eirini P. Papapetrou
Rodriguez-Fraticelli and colleagues combine genetic barcoding with ex vivo expansion and sister-cell analysis of murine hematopoietic stem cells (HSCs) carrying inducible leukemia driver mutations. This approach allows them to capture the intrinsic heterogeneity of clonal cell behaviors and study how these impact cell fates upon acquisition of leukemia driver mutations.
-
A robust ingredient makes human gut stem cell niches on a dish Cell Stem Cell (IF 19.8) Pub Date : 2025-04-03 Chiyeol Choi, Tae-Hee Kim
Human intestinal organoids (HIOs) generated from induced pluripotent stem cells (iPSCs) are utilized for disease modeling but they lack a full complement of niche components. Childs et al.1 demonstrate that EPIREGULIN-driven HIOs mature into functional, neuromuscular, and vascularized niches, establishing a powerful platform for human gut physiology and disease research.
-
Tonsils weigh in on flu-specific immunity Cell Stem Cell (IF 19.8) Pub Date : 2025-04-03 Petter Brodin
Wagoner et al.1 use human tonsil organoids to uncover key immune mechanisms driving influenza vaccine responses. They identify Th1 cell frequencies as a critical predictor of neutralizing antibody responses to inactivated vaccines, providing new insights into vaccine effectiveness and paving the way for more targeted vaccine development in the future.
-
Engineered heart tissue patches: A milestone in cardiac regenerative medicine Cell Stem Cell (IF 19.8) Pub Date : 2025-04-03 Alain van Mil, Jasmijn Janssen, Eva van Rooij
Researchers have demonstrated that a stem cell-derived heart muscle patch can safely remuscularize failing hearts.1 Published in Nature, the study shows successful long-term cardiac integration of a patch in a primate model and a human patient with no adverse effects. This breakthrough marks a major step toward regenerative therapies for advanced heart failure.
-
A call to action for deciphering genetic variants in human pluripotent stem cells for cell therapy Cell Stem Cell (IF 19.8) Pub Date : 2025-04-03 Nissim Benvenisty, Jonathan S. Draper, Paul J. Gokhale, Lyn Healy, Zoe Hewitt, Deborah Hursh, Adam Hodgson, Tenneille E. Ludwig, Nancy Mah, Sarah E. McClelland, Milena Mennecozzi, Florian T. Merkle, Joanne C. Mountford, Martin Pera, Alessandro Prigione, Tristan A. Rodriguez, Andrea Rossi, Foad J. Rouhani, Kourosh Saeb-Parsy, Lucia Selfa Aspiroz, Nika Shakiba, Claudia Spits, Peter D. Tonge, Ivana Barbaric
Human pluripotent stem cell (hPSC)-based therapies offer promise but pose potential risks due to culture-acquired genetic variants, some of which have been linked with cancer. An international workshop addressed these concerns, highlighting the need for improved strategies to stratify variants and chart a path toward definitive guidelines in hPSC-based therapy.
-
Progress and challenges in developing allogeneic cell therapies Cell Stem Cell (IF 19.8) Pub Date : 2025-04-03 Tobias Deuse, Sonja Schrepfer
The new era of cell therapeutics has started with autologous products to avoid immune rejection. However, therapeutics derived from allogeneic cells could be scaled and made available for a much larger patient population if immune rejection could reliably be overcome. In this review, we outline gene engineering concepts aimed at generating immune-evasive cells. First, we summarize the current state
-
Bioprinted platform for parallelized screening of engineered microtissues in vivo Cell Stem Cell (IF 19.8) Pub Date : 2025-03-31 Colleen E. O’Connor, Fan Zhang, Anna Neufeld, Olivia Prado, Susana P. Simmonds, Chelsea L. Fortin, Fredrik Johansson, Jonathan Mene, Sarah H. Saxton, Irina Kopyeva, Nicole E. Gregorio, Zachary James, Cole A. DeForest, Elizabeth C. Wayne, Daniela M. Witten, Kelly R. Stevens
-
Glucose modulates IRF6 transcription factor dimerization to enable epidermal differentiation Cell Stem Cell (IF 19.8) Pub Date : 2025-03-21 Vanessa Lopez-Pajares, Aparna Bhaduri, Yang Zhao, Gayatri Gowrishankar, Laura K.H. Donohue, Margaret G. Guo, Zurab Siprashvili, Weili Miao, Duy T. Nguyen, Xue Yang, Albert M. Li, Alan Sheng-Hwa Tung, Ronald L. Shanderson, Marten C.G. Winge, Lindsey M. Meservey, Suhas Srinivasan, Robin M. Meyers, Angela Guerrero, Andrew L. Ji, Omar S. Garcia, Shiying Tao, Sanjiv S. Gambhir, Jonathan Z. Long, Jiangbin
-
Vagal pathway activation links chronic stress to decline in intestinal stem cell function Cell Stem Cell (IF 19.8) Pub Date : 2025-03-21 Guoying Zhang, Yannan Lian, Qingguo Li, Shudi Zhou, Lili Zhang, Liting Chen, Junzhe Tang, Hailong Liu, Ni Li, Qiang Pan, Yongqiang Gu, Naiheng Lin, Hanling Wang, Xuege Wang, Jiacheng Guo, Wei Zhang, Zige Jin, Beitao Xu, Xiao Su, Moubin Lin, Qi Han, Jun Qin
-
Self-organization of mouse embryonic stem cells into reproducible pre-gastrulation embryo models via CRISPRa programming Cell Stem Cell (IF 19.8) Pub Date : 2025-03-20 Gerrald A. Lodewijk, Sayaka Kozuki, Clara J. Han, Benjamin R. Topacio, Seungho Lee, Lily Nixon, Abolfazl Zargari, Gavin Knight, Randolph Ashton, Lei S. Qi, S. Ali Shariati
-
Human skeletal development and regeneration are shaped by functional diversity of stem cells across skeletal sites Cell Stem Cell (IF 19.8) Pub Date : 2025-03-20 Thomas H. Ambrosi, Sahar Taheri, Kun Chen, Rahul Sinha, Yuting Wang, Ethan J. Hunt, L. Henry Goodnough, Matthew P. Murphy, Holly M. Steininger, Malachia Y. Hoover, Franco Felix, Kelly C. Weldon, Lauren S. Koepke, Jan Sokol, Daniel Dan Liu, Liming Zhao, Stephanie D. Conley, Wan-Jin Lu, Maurizio Morri, Norma F. Neff, Noelle L. Van Rysselberghe, Erika E. Wheeler, Yongheng Wang, J. Kent Leach, Augustine
-
m6A deficiency impairs hypothalamic neurogenesis of feeding-related neurons in mice and human organoids and leads to adult obesity in mice Cell Stem Cell (IF 19.8) Pub Date : 2025-03-19 Yachen Shen, Samuel Zheng Hao Wong, Tong Ma, Feng Zhang, Qing Wang, Riki Kawaguchi, Daniel H. Geschwind, Jeremy Wang, Chuan He, Guo-li Ming, Hongjun Song
-
Vascular network-inspired diffusible scaffolds for engineering functional midbrain organoids Cell Stem Cell (IF 19.8) Pub Date : 2025-03-17 Hongwei Cai, Chunhui Tian, Lei Chen, Yang Yang, Alfred Xuyang Sun, Kyle McCracken, Jason Tchieu, Mingxia Gu, Ken Mackie, Feng Guo
-
EZH1 repression generates mature iPSC-derived CAR T cells with enhanced antitumor activity Cell Stem Cell (IF 19.8) Pub Date : 2025-03-14 Ran Jing, Irene Scarfo, Mohamad Ali Najia, Edroaldo Lummertz da Rocha, Areum Han, Michael Sanborn, Trevor Bingham, Caroline Kubaczka, Deepak K. Jha, Marcelo Falchetti, Thorsten M. Schlaeger, Trista E. North, Marcela V. Maus, George Q. Daley
(Cell Stem Cell 29, 1181–1196.e1–e6; August 4, 2022)
-
Fetal-like reversion in the regenerating intestine is regulated by mesenchymal asporin Cell Stem Cell (IF 19.8) Pub Date : 2025-03-06 Sharif Iqbal, Simon Andersson, Ernesta Nesta, Nalle Pentinmikko, Ashish Kumar, Sawan Kumar Jha, Daniel Borshagovski, Anna Webb, Nadja Gebert, Emma W. Viitala, Alexandra Ritchie, Sandra Scharaw, Emilia Kuuluvainen, Hjalte L. Larsen, Tuure Saarinen, Anne Juuti, Ari Ristimäki, Michael Jeltsch, Alessandro Ori, Markku Varjosalo, Kirsi H. Pietiläinen, Saara Ollila, Kim B. Jensen, Menno J. Oudhoff, Pekka
-
Overcoming gene dosage barriers in mammalian development: An imprinting balancing act Cell Stem Cell (IF 19.8) Pub Date : 2025-03-06 Zhengfeng Liu, Marisa S. Bartolomei
Genomic imprinting ensures parent-of-origin gene expression and prevents uniparental development. In this issue of Cell Stem Cell, Li et al.1 extensively engineered androgenic haploid embryonic stem cells to overcome imprinting barriers, producing adult bi-paternal mice, albeit with low efficiency, and providing insights into roles of imprinted genes in development.
-
PSPC1 bridges cancer stemness and malignancy in acute myeloid leukemia Cell Stem Cell (IF 19.8) Pub Date : 2025-03-06 Hsi-Wen Yeh, Yaw-Dong Lang, Hsin-Yi Lee, Yuh-Shan Jou
In a recent publication in Cell Stem Cell, Hong et al.1 uncovered paraspeckle component 1 (PSPC1) as a determinant of leukemogenic characteristics in acute myeloid leukemia (AML). PSPC1 is not essential for normal hematopoiesis but it is upregulated to interact with PU.1 to promote AML progression and is also emerging as a therapeutic target.
-
Stripe out for brain evolution: Astrocytes go human Cell Stem Cell (IF 19.8) Pub Date : 2025-03-06 Lara López-González, Víctor Borrell
Evolution of the human brain involved neuron and glial cell changes. In this issue of Cell Stem Cell, Ciuba et al.1 identify an epigenetic mechanism central in the evolution of human astrocytes, where small enhancer modifications increased transcription factor binding, orchestrating transcriptomic changes that influence astrocyte structure and function.
-
Autologous cells, no longer lost in translation Cell Stem Cell (IF 19.8) Pub Date : 2025-03-06 Malin Parmar, Anna Falk
In 2020, a case report described autologous transplantation of iPSC-derived dopamine (DA) neurons in a Parkinson’s disease (PD) patient.1 The team now follows up with the pre-clinical safety and efficacy data of autologous iPSC-derived DA neurons, forming the basis for regulatory approval of a phase 1 clinical trial involving 8 patients.2
-
Coordinated differentiation of human intestinal organoids with functional enteric neurons and vasculature Cell Stem Cell (IF 19.8) Pub Date : 2025-03-04 Charlie J. Childs, Holly M. Poling, Kevin Chen, Yu-Hwai Tsai, Angeline Wu, Abigail Vallie, Madeline K. Eiken, Sha Huang, Caden W. Sweet, Ryan Schreiner, Zhiwei Xiao, Ryan C. Spencer, Samantha A. Paris, Ansley S. Conchola, Jonathan W. Villanueva, Meghan F. Anderman, Emily M. Holloway, Akaljot Singh, Roman J. Giger, Maxime M. Mahe, Claudia Loebel, Michael A. Helmrath, Katherine D. Walton, Shahin Rafii
-
Inhibition of PRC2 enables self-renewal of blastoid-competent naive pluripotent stem cells from chimpanzee Cell Stem Cell (IF 19.8) Pub Date : 2025-02-26 Tao Huang, Arthur Radley, Ayaka Yanagida, Zhili Ren, Francesca Carlisle, Somayyeh Tahajjodi, Dongwan Kim, Paul O’Neill, James Clarke, Madeline A. Lancaster, Zoe Heckhausen, Jingran Zhuo, João Pedro Agostinho de Sousa, Petra Hajkova, Ferdinand von Meyenn, Hiroo Imai, Hiromitsu Nakauchi, Ge Guo, Austin Smith, Hideki Masaki
-
Interferon-responsive intestinal BEST4/CA7+ cells are targets of bacterial diarrheal toxins Cell Stem Cell (IF 19.8) Pub Date : 2025-02-25 Daisong Wang, Willem Kasper Spoelstra, Lin Lin, Ninouk Akkerman, Daniel Krueger, Talya Dayton, Jeroen S. van Zon, Sander J. Tans, Johan H. van Es, Hans Clevers
-
Pre-existing stem cell heterogeneity dictates clonal responses to the acquisition of leukemic driver mutations Cell Stem Cell (IF 19.8) Pub Date : 2025-02-25 Indranil Singh, Daniel Fernandez-Perez, Pedro Sanchez Sanchez, Alejo E. Rodriguez-Fraticelli
-
Enhanced viability and functional maturity of iPSC-derived islet organoids by collagen-VI-enriched ECM scaffolds Cell Stem Cell (IF 19.8) Pub Date : 2025-02-24 Deliang Zhu, Zixin Chen, Kaimin Guo, Qingqiang Xie, Yuxiu Zou, Qizheng Mou, Zhongjun Zhou, Guoxiang Jin
-
Mechano-oncogenic cytoskeletal remodeling drives leukemic transformation with mitochondrial vesicle-mediated STING activation Cell Stem Cell (IF 19.8) Pub Date : 2025-02-21 Zemin Song, Yali Cui, Lilan Xin, Ruijing Xiao, Jingjing Feng, Conghui Li, Zhinang Yin, Honghong Wang, Qiuzi Li, Mengxuan Wang, Baoyi Lin, Yiming Zhang, Ying Zhou, Li Huang, Yanli He, Xiaoqing Li, Xiaoyan Liu, Shangqin Liu, Fuling Zhou, Zheng Liu, Hai-Bing Zhou, Pingping Fang, Kaiwei Liang
-
Systems immunology analysis of human immune organoids identifies host-specific correlates of protection to different influenza vaccines Cell Stem Cell (IF 19.8) Pub Date : 2025-02-21 Zachary W. Wagoner, Timothy B. Yates, Jenny E. Hernandez-Davies, Suhas Sureshchandra, Erika M. Joloya, Aarti Jain, Rafael de Assis, Jenna M. Kastenschmidt, Andrew M. Sorn, Mahina Tabassum Mitul, Ian Tamburini, Gurpreet Ahuja, Qiu Zhong, Douglas Trask, Marcus Seldin, D. Huw Davies, Lisa E. Wagar
-
Sustained NF-κB activation allows mutant alveolar stem cells to co-opt a regeneration program for tumor initiation Cell Stem Cell (IF 19.8) Pub Date : 2025-02-19 Frances J. England, Ignacio Bordeu, Minn-E. Ng, JaeHak Bang, Bumsoo Kim, Jinwook Choi, Erik C. Cardoso, Bon-Kyoung Koo, Benjamin D. Simons, Joo-Hyeon Lee
-
PSPC1 exerts an oncogenic role in AML by regulating a leukemic transcription program in cooperation with PU.1 Cell Stem Cell (IF 19.8) Pub Date : 2025-02-14 Juyeong Hong, Pinpin Sui, Ying Li, Kerryn Y. Xu, Ji-Hoon Lee, Juan Wang, Shi Chen, Peng Zhang, Noah Wingate, Asra Noor, Yaxia Yuan, Robert Hromas, Hongwei Zhou, Karina Hamamoto, Rui Su, C. Cameron Yin, Fengxi Ye, Andrés E. Quesada, Jianjun Chen, Suming Huang, Daohong Zhou, M. James You, Feng-Chun Yang, Jianlong Wang, Mingjiang Xu
-
Pre-clinical safety and efficacy of human induced pluripotent stem cell-derived products for autologous cell therapy in Parkinson’s disease Cell Stem Cell (IF 19.8) Pub Date : 2025-02-13 Jeha Jeon, Young Cha, Yean Ju Hong, In-Hee Lee, Heejin Jang, Sanghyeok Ko, Serhiy Naumenko, Minseon Kim, Hannah L. Ryu, Zenith Shrestha, Nayeon Lee, Tae-Yoon Park, HoeWon Park, Seo-Hyun Kim, Ki-Jun Yoon, Bin Song, Jeffrey Schweitzer, Todd M. Herrington, Sek Won Kong, Bob Carter, Pierre Leblanc, Kwang-Soo Kim
-
Individualized patient tumor organoids faithfully preserve human brain tumor ecosystems and predict patient response to therapy Cell Stem Cell (IF 19.8) Pub Date : 2025-02-11 Tianping Peng, Xiujian Ma, Wei Hua, Changwen Wang, Youjun Chu, Meng Sun, Valentina Fermi, Stefan Hamelmann, Katharina Lindner, Chunxuan Shao, Julia Zaman, Weili Tian, Yue Zhuo, Yassin Harim, Nadja Stöffler, Linda Hammann, Qungen Xiao, Xiaoliang Jin, Rolf Warta, Catharina Lotsch, Xuran Zhuang, Yuan Feng, Minjie Fu, Xin Zhang, Jinsen Zhang, Hao Xu, Fufang Qiu, Liqian Xie, Yi Zhang, Wei Zhu, Zunguo Du
-
Cognitive impairment in epilepsy progression: Adult neurogenesis loss at critical window Cell Stem Cell (IF 19.8) Pub Date : 2025-02-06 Yi Wang, Zhong Chen
The mechanisms underlying cognitive impairment in epilepsy remain poorly understood. Ammothumkandy et al.1 reveal that the loss of adult immature neurons correlates with auditory verbal learning deficits in human mesial temporal lobe epilepsy during a critical disease period, underscoring the pivotal role of adult neurogenesis in specific cognitive domain.
-
Pre-birth stem cell education: A gift from mother’s bugs Cell Stem Cell (IF 19.8) Pub Date : 2025-02-06 Chenyan Huang, Ai Ing Lim
The maternal gut microbiota undergoes significant changes during pregnancy and plays a pivotal role in offspring development. In this issue, Dang et al. demonstrate that modifying the maternal gut microbiome during pregnancy shapes offspring neural and intestinal stem cells via the mTOR pathway, with long-lasting effects on their functions.
-
Human iPSCs offer an alternative for modeling vascular malformation Cell Stem Cell (IF 19.8) Pub Date : 2025-02-06 Stefanie DeFronzo, Guohao Dai
In this issue of Cell Stem Cell, Pan et al. generated human induced pluripotent stem cell (iPSC)-derived venous endothelial cells (iVECs) by manipulating cell-cycle dynamics and Notch signaling and demonstrated that TIE2-mutant iVECs recapitulate the pathogenesis of venous malformations.1 Their study provides a model for further mechanistic studies and drug discovery.
-
Two is better than one: Advancing gene therapy protocols for enhanced safety and efficacy Cell Stem Cell (IF 19.8) Pub Date : 2025-02-06 Giulia Hardouin, Annarita Miccio
In this issue of Cell Stem Cell, two complementary studies from Zeng et al.1 and Demirci et al.2 improve the efficacy of gene therapy for β-hemoglobinopathies using multiplex CRISPR-Cas9 editing. The authors also optimize editing and conditioning protocols to reduce risks associated with current gene therapy procedures.
-
Neural stem cell quiescence and activation dynamics are regulated by feedback input from their progeny under homeostatic and regenerative conditions Cell Stem Cell (IF 19.8) Pub Date : 2025-02-06 Alina Marymonchyk, Raquel Rodriguez-Aller, Ashleigh Willis, Frédéric Beaupré, Sareen Warsi, Marina Snapyan, Valérie Clavet-Fournier, Flavie Lavoie-Cardinal, David R. Kaplan, Freda D. Miller, Armen Saghatelyan
-
Molecular signature of primate astrocytes reveals pathways and regulatory changes contributing to human brain evolution Cell Stem Cell (IF 19.8) Pub Date : 2025-02-04 Katarzyna Ciuba, Aleksandra Piotrowska, Debadeep Chaudhury, Bondita Dehingia, Eryk Duński, Rüdiger Behr, Karolina Soroczyńska, Małgorzata Czystowska-Kuźmicz, Misbah Abbas, Edyta Bulanda, Sylwia Gawlik-Zawiślak, Sylwia Pietrzak, Izabela Figiel, Jakub Włodarczyk, Alexei Verkhratsky, Marcin Niedbała, Wojciech Kaspera, Tomasz Wypych, Bartosz Wilczyński, Aleksandra Pękowska
-
Genome-wide CRISPR activation screening in senescent cells reveals SOX5 as a driver and therapeutic target of rejuvenation Cell Stem Cell (IF 19.8) Pub Date : 2025-01-28 Yaobin Jing, Xiaoyu Jiang, Qianzhao Ji, Zeming Wu, Wei Wang, Zunpeng Liu, Pedro Guillen-Garcia, Concepcion Rodriguez Esteban, Pradeep Reddy, Steve Horvath, Jingyi Li, Lingling Geng, Qinchao Hu, Si Wang, Juan Carlos Izpisua Belmonte, Jie Ren, Weiqi Zhang, Jing Qu, Guang-Hui Liu
(Cell Stem Cell 30, 1452–1471.e1–e10; November 2, 2023)
-
Adult bi-paternal offspring generated through direct modification of imprinted genes in mammals Cell Stem Cell (IF 19.8) Pub Date : 2025-01-28 Zhi-kun Li, Li-bin Wang, Le-yun Wang, Xue-han Sun, Ze-hui Ren, Si-nan Ma, Yu-long Zhao, Chao Liu, Gui-hai Feng, Tao Liu, Tian-shi Pan, Qing-tong Shan, Kai Xu, Guan-zheng Luo, Qi Zhou, Wei Li
-
Pluripotent stem-cell-derived therapies in clinical trial: A 2025 update Cell Stem Cell (IF 19.8) Pub Date : 2025-01-25 Agnete Kirkeby, Heather Main, Melissa Carpenter
(Cell Stem Cell 32, 10–37; January 2, 2025)