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Cis-regulatory arbitrators of regeneration Cell Stem Cell (IF 23.9) Pub Date : 2023-09-14 Piotr Konieczny, Shruti Naik
Mammals favor healing with scaring over functional tissue regeneration.1 In this issue of Cell Stem Cell, Mack et al. use “super-healer” mice to identify cis-regulatory variations that direct regenerative versus fibrotic gene expression in wound fibroblasts and they uncover complement factor H as a molecular driver of skin regeneration.2
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Allele-specific expression reveals genetic drivers of tissue regeneration in mice Cell Stem Cell (IF 23.9) Pub Date : 2023-09-14 Katya L. Mack, Heather E. Talbott, Michelle F. Griffin, Jennifer B.L. Parker, Nicholas J. Guardino, Amanda F. Spielman, Michael F. Davitt, Shamik Mascharak, Mauricio Downer, Annah Morgan, Caleb Valencia, Deena Akras, Mark J. Berger, Derrick C. Wan, Hunter B. Fraser, Michael T. Longaker
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Lgr5-expressing secretory cells form a Wnt inhibitory niche in cartilage critical for chondrocyte identity Cell Stem Cell (IF 23.9) Pub Date : 2023-09-07 Angela Ruscitto, Peng Chen, Ikue Tosa, Ziyi Wang, Gan Zhou, Ingrid Safina, Ran Wei, Mallory M. Morel, Alia Koch, Michael Forman, Gwendolyn Reeve, Michael K. Lecholop, Marshall Wilson, Daniel Bonthius, Mo Chen, Mitsuaki Ono, Timothy C. Wang, Hai Yao, Mildred C. Embree
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Having a blast(oid): Modeling human embryo peri-implantation development with blastoids Cell Stem Cell (IF 23.9) Pub Date : 2023-09-07 Eva Moinard, Vincent Pasque, Laurent David
Studying human embryo development, most particularly around the time of implantation, is a challenge, yet it is necessary to improve assisted reproduction techniques. In this issue, Yu et al.1 and Karvas et al.2 improve integrated stem cell models, called blastoids, to model the peri-implantation human embryo.
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Lung repair empowered by exogenous cells taking residence Cell Stem Cell (IF 23.9) Pub Date : 2023-09-07 Le Xu, Xin Sun
Stem cell therapy uses transplantation of exogenous stem cells to repair damaged tissues. In this issue of Cell Stem Cell, Ma et al. and Herriges et al. reported durable engraftment of pluripotent stem cell (PSC)-derived airway and alveolar epithelial progenitor cells, respectively, in the mouse lung.
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3D-cultured blastoids model human embryogenesis from pre-implantation to early gastrulation stages Cell Stem Cell (IF 23.9) Pub Date : 2023-09-07 Rowan M. Karvas, Joseph E. Zemke, Syed Shahzaib Ali, Eric Upton, Eshan Sane, Laura A. Fischer, Chen Dong, Kyoung-mi Park, Fei Wang, Kibeom Park, Senyue Hao, Brian Chew, Brittany Meyer, Chao Zhou, Sabine Dietmann, Thorold W. Theunissen
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Generation of a humanized mesonephros in pigs from induced pluripotent stem cells via embryo complementation Cell Stem Cell (IF 23.9) Pub Date : 2023-09-07 Jiaowei Wang, Wenguang Xie, Nan Li, Wenjuan Li, Zhishuai Zhang, Nana Fan, Zhen Ouyang, Yu Zhao, Chengdan Lai, Hao Li, Mengqi Chen, Longquan Quan, Yunpan Li, Yu Jiang, Wenqi Jia, Lixin Fu, Md. Abdul Mazid, Yanling Zhu, Patrick H. Maxwell, Guangjin Pan, Liangxue Lai
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Large-scale production of human blastoids amenable to modeling blastocyst development and maternal-fetal cross talk Cell Stem Cell (IF 23.9) Pub Date : 2023-09-07 Leqian Yu, Deirdre Logsdon, Carlos A. Pinzon-Arteaga, Jialei Duan, Toshihiko Ezashi, Yulei Wei, Ana Elisa Ribeiro Orsi, Seiya Oura, Lizhong Liu, Lei Wang, Kun Liu, Xiaoyun Ding, Linfeng Zhan, Junfei Zhang, Asrafun Nahar, Caitlen Stobbe, Mandy Katz-Jaffe, William B. Schoolcraft, Tao Tan, Gary C. Hon, Jun Wu
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iPSC modeling of stage-specific leukemogenesis reveals BAALC as a key oncogene in severe congenital neutropenia Cell Stem Cell (IF 23.9) Pub Date : 2023-09-07 Benjamin Dannenmann, Maksim Klimiankou, Benedikt Oswald, Anna Solovyeva, Jehan Mardan, Masoud Nasri, Malte Ritter, Azadeh Zahabi, Patricia Arreba-Tutusaus, Perihan Mir, Frederic Stein, Siarhei Kandabarau, Nico Lachmann, Thomas Moritz, Tatsuya Morishima, Martina Konantz, Claudia Lengerke, Tim Ripperger, Doris Steinemann, Miriam Erlacher, Julia Skokowa
Abstract not available
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LIF signaling regulates outer radial glial to interneuron fate during human cortical development Cell Stem Cell (IF 23.9) Pub Date : 2023-09-05 Madeline G. Andrews, Clara Siebert, Li Wang, Matthew L. White, Jayden Ross, Raul Morales, Megan Donnay, Gradi Bamfonga, Tanzila Mukhtar, Arpana Arjun McKinney, Kaila Gemenes, Shaohui Wang, Qiuli Bi, Elizabeth E. Crouch, Neelroop Parikshak, Georgia Panagiotakos, Eric Huang, Aparna Bhaduri, Arnold R. Kriegstein
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Durable alveolar engraftment of PSC-derived lung epithelial cells into immunocompetent mice Cell Stem Cell (IF 23.9) Pub Date : 2023-08-24 Michael J. Herriges, Maria Yampolskaya, Bibek R. Thapa, Jonathan Lindstrom-Vautrin, Feiya Wang, Jessie Huang, Cheng-Lun Na, Liang Ma, McKenna M. Montminy, Pushpinder Bawa, Carlos Villacorta-Martin, Pankaj Mehta, Darrell N. Kotton
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Chemical reprogramming for cell fate manipulation: Methods, applications, and perspectives Cell Stem Cell (IF 23.9) Pub Date : 2023-08-24 Jinlin Wang, Shicheng Sun, Hongkui Deng
Chemical reprogramming offers an unprecedented opportunity to control somatic cell fate and generate desired cell types including pluripotent stem cells for applications in biomedicine in a precise, flexible, and controllable manner. Recent success in the chemical reprogramming of human somatic cells by activating a regeneration-like program provides an alternative way of producing stem cells for clinical
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Airway stem cell reconstitution by the transplantation of primary or pluripotent stem cell-derived basal cells Cell Stem Cell (IF 23.9) Pub Date : 2023-08-24 Liang Ma, Bibek R. Thapa, Jake A. Le Suer, Andrew Tilston-Lünel, Michael J. Herriges, Andrew Berical, Mary Lou Beermann, Feiya Wang, Pushpinder S. Bawa, Anat Kohn, Alexandra B. Ysasi, Hirofumi Kiyokawa, Taylor M. Matte, Scott H. Randell, Xaralabos Varelas, Finn J. Hawkins, Darrell N. Kotton
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Adrenergic nerves regulate intestinal regeneration through IL-22 signaling from type 3 innate lymphoid cells Cell Stem Cell (IF 23.9) Pub Date : 2023-08-18 Putianqi Wang, Noelyn Kljavin, Thi Thu Thao Nguyen, Elaine E. Storm, Bryan Marsh, Jian Jiang, William Lin, Hari Menon, Robert Piskol, Frederic J. de Sauvage
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Single-cell multi-omics defines the cell-type-specific impact of splicing aberrations in human hematopoietic clonal outgrowths Cell Stem Cell (IF 23.9) Pub Date : 2023-08-14 Mariela Cortés-López, Paulina Chamely, Allegra G. Hawkins, Robert F. Stanley, Ariel D. Swett, Saravanan Ganesan, Tarek H. Mouhieddine, Xiaoguang Dai, Lloyd Kluegel, Celine Chen, Kiran Batta, Nili Furer, Rahul S. Vedula, John Beaulaurier, Alexander W. Drong, Scott Hickey, Neville Dusaj, Gavriel Mullokandov, Adam M. Stasiw, Jiayu Su, Dan A. Landau
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Replacing microglia to treat Alzheimer’s disease Cell Stem Cell (IF 23.9) Pub Date : 2023-08-03 Peng Jiang, Mengmeng Jin
In this issue of Cell Stem Cell, Yoo et al.1 report that replacing Trem2 knockout microglia with Trem2 wild-type microglia-like cells derived from systemically transplanted hematopoietic cells rectifies microglial dysfunction in a mouse model of amyloidosis. These findings highlight the potential of microglia replacement therapy for Alzheimer’s disease treatment.
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Pancreatic acinar heterogeneity hijacks carcinogenesis and homeostasis Cell Stem Cell (IF 23.9) Pub Date : 2023-08-03 Michael Karl Melzer, Alexander Kleger
In this issue, Jiang and colleagues employ multiple lineage-tracing approaches to elaborate on the role of Tff2+ transit-amplifying progenitor cells in the pancreatic acinar compartment of mice. This work provides insights into the steady-state homeostasis and tumor-suppressive features of certain progenitor cells and presents findings on acinar cell heterogeneity.
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Dawn of development: Exploring early human embryogenesis using stem cells Cell Stem Cell (IF 23.9) Pub Date : 2023-08-03 Timothy Theodore Ka Ki Tam, Shao Xu, Pentao Liu, Alejandro De Los Angeles
Exploring the early stages of human embryonic development poses significant difficulties owing to ethical and technical limitations. Two recent studies in Nature report the self-organization of human stem cells into 3D embryoids that model features of the early post-implantation stages of human development.1,2
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Regulation of advanced therapies in Europe: Are we on the right track? Cell Stem Cell (IF 23.9) Pub Date : 2023-08-03 Ander Izeta, Natividad Cuende
Sixteen years after regulating advanced therapy medicinal products (ATMPs) in the European Union, few ATMPs have gained marketing authorization. Additionally, market withdrawals for commercial reasons and a lack of reimbursement are de facto blocking patient access. Here, we pinpoint the major factors underlying this roadblock and how to circumvent it.
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Advances and challenges toward developing kidney organoids for clinical applications Cell Stem Cell (IF 23.9) Pub Date : 2023-08-03 Ryuichi Nishinakamura
Kidney organoids have enabled modeling of human development and disease. While methods of generating the nephron lineage are well established, new protocols to induce another lineage, the ureteric bud/collecting duct, have been reported in the past 5 years. Many reports have described modeling of various hereditary kidney diseases, with polycystic kidney disease serving as the archetypal disease, by
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Enhanced glycolysis-mediated energy production in alveolar stem cells is required for alveolar regeneration Cell Stem Cell (IF 23.9) Pub Date : 2023-08-03 Zheng Wang, Dongdong Wei, Ennan Bin, Jiao Li, Kewu Jiang, Tingting Lv, Xiaoxu Mao, Fengchao Wang, Huaping Dai, Nan Tang
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A cell therapy approach to restore microglial Trem2 function in a mouse model of Alzheimer’s disease Cell Stem Cell (IF 23.9) Pub Date : 2023-08-03 Yongjin Yoo, Gernot Neumayer, Yohei Shibuya, Marius Marc-Daniel Mader, Marius Wernig
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20-αHydroxycholesterol, an oxysterol in human breast milk, reverses mouse neonatal white matter injury through Gli-dependent oligodendrogenesis Cell Stem Cell (IF 23.9) Pub Date : 2023-08-03 Agnes S. Chao, Pavle Matak, Kelly Pegram, James Powers, Collin Hutson, Rebecca Jo, Laura Dubois, J. Will Thompson, P. Brian Smith, Vaibhav Jain, Chunlei Liu, Noelle E. Younge, Blaire Rikard, Estefany Y. Reyes, Mari L. Shinohara, Simon G. Gregory, Ronald N. Goldberg, Eric J. Benner
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TET2-mediated mRNA demethylation regulates leukemia stem cell homing and self-renewal Cell Stem Cell (IF 23.9) Pub Date : 2023-08-03 Yangchan Li, Meilin Xue, Xiaolan Deng, Lei Dong, Le Xuan Truong Nguyen, Lili Ren, Li Han, Chenying Li, Jianhuang Xue, Zhicong Zhao, Wei Li, Ying Qing, Chao Shen, Brandon Tan, Zhenhua Chen, Keith Leung, Kitty Wang, Srividya Swaminathan, Ling Li, Mark Wunderlich, Jianjun Chen
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Tff2 defines transit-amplifying pancreatic acinar progenitors that lack regenerative potential and are protective against Kras-driven carcinogenesis Cell Stem Cell (IF 23.9) Pub Date : 2023-08-03 Zhengyu Jiang, Feijing Wu, Pasquale Laise, Tanaka Takayuki, Fu Na, Woosook Kim, Hiroki Kobayashi, Wenju Chang, Ryota Takahashi, Giovanni Valenti, Masaki Sunagawa, Ruth A. White, Marina Macchini, Bernhard W. Renz, Moritz Middelhoff, Yoku Hayakawa, Zinaida A. Dubeykovskaya, Xiangtian Tan, Timothy H. Chu, Karan Nagar, Timothy C. Wang
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Genetic reporter for live tracing fluid flow forces during cell fate segregation in mouse blastocyst development Cell Stem Cell (IF 23.9) Pub Date : 2023-08-03 Youdong Zhang, Xin Li, Shu Gao, Yuanhui Liao, Yingjie Luo, Min Liu, Yunkun Bian, Haiqing Xiong, Yanzhu Yue, Aibin He
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Regulation of developmental tempo in different vertebrate species Cell Stem Cell (IF 23.9) Pub Date : 2023-07-06 Carmen Birchmeier
In this issue, Lazaro et al.1 use iPSC-derived presomitic mesoderm cells to analyze the oscillatory expression of somitic clock genes. Comparison of a wide range of species, including mouse, rabbit, cattle, rhinoceros, human, and marmoset, demonstrates an excellent correlation between biochemical reaction speed and the tempo of the clock.
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Context matters: hPSC-derived microglia thrive in a humanized brain environment in vivo Cell Stem Cell (IF 23.9) Pub Date : 2023-07-06 Jonas Cerneckis, Yanhong Shi
It remains challenging to create a physiologically relevant human-brain-like environment that would support maturation of human pluripotent stem cell (hPSC)-derived microglia (hMGs). Schafer et al.1 (Cell, 2023) now develop an in vivo neuroimmune organoid model with mature homeostatic hMGs for the study of brain development and disease.
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Prolonged 3D culture unlocks black box of primate embryogenesis Cell Stem Cell (IF 23.9) Pub Date : 2023-07-06 Ziyi Li, Fan Zhou
By developing in vitro 3D culture systems and identifying morphological and molecular events of early organogenesis, two recent studies1,2 reported exciting research advances in non-human primate embryo development.
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Too little, too soon: Japan’s experiment in regenerative medicine deregulation Cell Stem Cell (IF 23.9) Pub Date : 2023-07-06 David Cyranoski, Douglas Sipp, Shreyashee Mallik, John E.J. Rasko
In 2013, Japan established a conditional approval pathway for cell and gene therapies. Our analysis of the four products approved via this pathway identifies evidence suggesting shortcomings in safety and efficacy data submitted by the sponsors and raises concerns about whether this pathway is delivering on its promise.
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Generating high-fidelity cochlear organoids from human pluripotent stem cells Cell Stem Cell (IF 23.9) Pub Date : 2023-07-06 Stephen T. Moore, Takashi Nakamura, Jing Nie, Alexander J. Solivais, Isabel Aristizábal-Ramírez, Yoshitomo Ueda, Mayakannan Manikandan, V. Shweta Reddy, Daniel R. Romano, John R. Hoffman, Benjamin J. Perrin, Rick F. Nelson, Gregory I. Frolenkov, Susana M. Chuva de Sousa Lopes, Eri Hashino
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Organ function is preserved despite reorganization of niche architecture in the hair follicle Cell Stem Cell (IF 23.9) Pub Date : 2023-07-06 Haoyang Wei, Shuangshuang Du, Jeeun Parksong, H. Amalia Pasolli, Catherine Matte-Martone, Sergi Regot, Lauren E. Gonzalez, Tianchi Xin, Valentina Greco
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Human stem cell-derived embryo models: Toward ethically appropriate regulations and policies Cell Stem Cell (IF 23.9) Pub Date : 2023-07-03 Alessandro Blasimme, Jeremy Sugarman
Human pluripotent stem cells can be used to derive in vitro models recapitulating post-implantation human embryos. While useful for research purposes, such integrated embryo models raise ethical issues that need to be addressed to facilitate ethically appropriate policies and regulations that permit scientific ingenuity and medical progress.
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Controlling genetic heterogeneity in gene-edited hematopoietic stem cells by single-cell expansion Cell Stem Cell (IF 23.9) Pub Date : 2023-06-28 Hans Jiro Becker, Reiko Ishida, Adam C. Wilkinson, Takaharu Kimura, Michelle Sue Jann Lee, Cevayir Coban, Yasunori Ota, Yosuke Tanaka, Meike Roskamp, Tsubasa Sano, Arinobu Tojo, David G. Kent, Satoshi Yamazaki
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A stem cell zoo uncovers intracellular scaling of developmental tempo across mammals Cell Stem Cell (IF 23.9) Pub Date : 2023-06-20 Jorge Lázaro, Maria Costanzo, Marina Sanaki-Matsumiya, Charles Girardot, Masafumi Hayashi, Katsuhiko Hayashi, Sebastian Diecke, Thomas B. Hildebrandt, Giovanna Lazzari, Jun Wu, Stoyan Petkov, Rüdiger Behr, Vikas Trivedi, Mitsuhiro Matsuda, Miki Ebisuya
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Advanced human iPSC-based preclinical model for Parkinson’s disease with optogenetic alpha-synuclein aggregation Cell Stem Cell (IF 23.9) Pub Date : 2023-06-19 Min Seong Kim, Eun A. Ra, Sin Ho Kweon, Bo Am Seo, Han Seok Ko, Yohan Oh, Gabsang Lee
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Organoid cultures for cancer modeling Cell Stem Cell (IF 23.9) Pub Date : 2023-06-13 Helen H.N. Yan, April S. Chan, Frank Pui-Ling Lai, Suet Yi Leung
Organoids derived from adult stem cells (ASCs) and pluripotent stem cells (PSCs) are important preclinical models for studying cancer and developing therapies. Here, we review primary tissue-derived and PSC-derived cancer organoid models and detail how they have the potential to inform personalized medical approaches in different organ contexts and contribute to the understanding of early carcinogenic
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Advanced human iPSC-based preclinical model for Parkinson's disease with optogenetic alpha-synuclein aggregation. Cell Stem Cell (IF 23.9) Pub Date : 2023-06-19 Min Seong Kim,Eun A Ra,Sin Ho Kweon,Bo Am Seo,Han Seok Ko,Yohan Oh,Gabsang Lee
Human induced pluripotent stem cells (hiPSCs) offer advantages for disease modeling and drug discovery. However, recreating innate cellular pathologies, particularly in late-onset neurodegenerative diseases with accumulated protein aggregates including Parkinson's disease (PD), has been challenging. To overcome this barrier, we developed an optogenetics-assisted α-synuclein (α-syn) aggregation induction
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Unlocking the secrets of cancer stem cells: Immune checkpoint inhibitors face their formidable foes Cell Stem Cell (IF 23.9) Pub Date : 2023-06-01 Kevin Roarty
In this issue of Cell Stem Cell, Beziaud et al.1 show that immunotherapy induces stem-like properties in models of breast cancer. Strikingly, T-cell-derived IFNγ promotes cancer stem cell (CSC) phenotypes, therapy resistance, and metastasis. Targeting BCAT1 downstream offers promise for enhancing immunotherapy outcomes.
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We need to talk about lung cancer’s cholesterol-hoarding problem Cell Stem Cell (IF 23.9) Pub Date : 2023-06-01 Michael B. Fessler
Proliferative cells require excess cholesterol to support rapid membrane biogenesis. Using a mutant KRAS mouse model of non-small cell lung cancer, Guilbaud et al. show that lung cancers accumulate cholesterol by locally and distally reprogramming lipid trafficking and that cholesterol-removing interventions may hold promise as a therapeutic strategy.
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iPSC-based research in ALS precision medicine Cell Stem Cell (IF 23.9) Pub Date : 2023-06-01 Letizia Mazzini, Fabiola De Marchi
Clinical trials in amyotrophic lateral sclerosis (ALS) are challenged by the lack of pre-clinical models and biomarkers of disease onset and progression. In this issue, Morimoto et al. use induced pluripotent stem cell (iPSC)-derived motor neurons from patients with ALS to study therapeutic mechanisms of ropinirole in a clinical trial and identify treatment responders.
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Getting physical: Material mechanics is an intrinsic cell cue Cell Stem Cell (IF 23.9) Pub Date : 2023-06-01 Hamza Atcha, Yu Suk Choi, Ovijit Chaudhuri, Adam J. Engler
Advances in biomaterial science have allowed for unprecedented insight into the ability of material cues to influence stem cell function. These material approaches better recapitulate the microenvironment, providing a more realistic ex vivo model of the cell niche. However, recent advances in our ability to measure and manipulate niche properties in vivo have led to novel mechanobiological studies
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Phase 1/2a clinical trial in ALS with ropinirole, a drug candidate identified by iPSC drug discovery Cell Stem Cell (IF 23.9) Pub Date : 2023-06-01 Satoru Morimoto, Shinichi Takahashi, Daisuke Ito, Yugaku Daté, Kensuke Okada, Chris Kato, Shiho Nakamura, Fumiko Ozawa, Chai Muh Chyi, Ayumi Nishiyama, Naoki Suzuki, Koki Fujimori, Tosho Kondo, Masaki Takao, Miwa Hirai, Yasuaki Kabe, Makoto Suematsu, Masahiro Jinzaki, Masashi Aoki, Yuto Fujiki, Hideyuki Okano
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Loss of TET2 in human hematopoietic stem cells alters the development and function of neutrophils Cell Stem Cell (IF 23.9) Pub Date : 2023-06-01 Hector Huerga Encabo, Iker Valle Aramburu, Manuel Garcia-Albornoz, Marion Piganeau, Henry Wood, Anna Song, Alessandra Ferrelli, Aneesh Sharma, Carlos M. Minutti, Marie-Charlotte Domart, Despoina Papazoglou, Kristian Gurashi, Miriam Llorian Sopena, Robert Goldstone, Todd Fallesen, Qian Wang, Linda Ariza-McNaughton, Daniel H. Wiseman, Kiran Batta, Rajeev Gupta, Dominique Bonnet
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Cholesterol efflux pathways hinder KRAS-driven lung tumor progenitor cell expansion Cell Stem Cell (IF 23.9) Pub Date : 2023-06-01 Emma Guilbaud, Thibault Barouillet, Marius Ilie, Coraline Borowczyk, Stoyan Ivanov, Vincent Sarrazy, Nathalie Vaillant, Marion Ayrault, Alexia Castiglione, Guylène Rignol, Patrick Brest, Venetia Bazioti, Konstantin Zaitsev, Kevin Lebrigand, Sébastien Dussaud, Virginie Magnone, Corine Bertolotto, Sandrine Marchetti, Marie Irondelle, Ira Goldberg, Laurent Yvan-Charvet
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IFNγ-induced stem-like state of cancer cells as a driver of metastatic progression following immunotherapy Cell Stem Cell (IF 23.9) Pub Date : 2023-06-01 Laurent Beziaud, C. Megan Young, Angela Madurga Alonso, Maxim Norkin, Anna Rita Minafra, Joerg Huelsken
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Systematic dissection of coordinated stromal remodeling identifies Sox10+ glial cells as a therapeutic target in myelofibrosis Cell Stem Cell (IF 23.9) Pub Date : 2023-06-01 Shawn M. Sarkaria, Junsong Zhou, Suying Bao, Wenqi Zhao, Yinshan Fang, Jianwen Que, Govind Bhagat, Chaolin Zhang, Lei Ding
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Transcriptional space-time mapping identifies concerted immune and stromal cell patterns and gene programs in wound healing and cancer Cell Stem Cell (IF 23.9) Pub Date : 2023-06-01 Kenneth H. Hu, Nicholas F. Kuhn, Tristan Courau, Jessica Tsui, Bushra Samad, Patrick Ha, Johannes R. Kratz, Alexis J. Combes, Matthew F. Krummel
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Retraction Notice to: shRNA Knockdown of Bmi-1 Reveals a Critical Role for p21-Rb Pathway in NSC Self-Renewal during Development Cell Stem Cell (IF 23.9) Pub Date : 2023-06-01 Christopher A. Fasano, John T. Dimos, Natalia B. Ivanova, Natalia Lowry, Ihor R. Lemischka, Sally Temple
Abstract not available
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Retraction Notice to: Efficient Derivation of Functional Floor Plate Tissue from Human Embryonic Stem Cells Cell Stem Cell (IF 23.9) Pub Date : 2023-06-01 Christopher A. Fasano, Stuart M. Chambers, Gabsang Lee, Mark J. Tomishima, Lorenz Studer
Abstract not available
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Multimodal characterization of murine gastruloid development Cell Stem Cell (IF 23.9) Pub Date : 2023-05-19 Simon Suppinger, Marietta Zinner, Nadim Aizarani, Ilya Lukonin, Raphael Ortiz, Chiara Azzi, Michael B. Stadler, Stefano Vianello, Giovanni Palla, Hubertus Kohler, Alexandre Mayran, Matthias P. Lutolf, Prisca Liberali
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The single-cell and spatial transcriptional landscape of human gastrulation and early brain development Cell Stem Cell (IF 23.9) Pub Date : 2023-05-15 Bo Zeng, Zeyuan Liu, Yufeng Lu, Suijuan Zhong, Shenyue Qin, Luwei Huang, Yang Zeng, Zixiao Li, Hao Dong, Yingchao Shi, Jialei Yang, Yalun Dai, Qiang Ma, Le Sun, Lihong Bian, Dan Han, Youqiao Chen, Xin Qiu, Wei Wang, Oscar Marín, Xiaoqun Wang
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hPSCs-derived Schwann cells serve for disease modeling and drug discovery Cell Stem Cell (IF 23.9) Pub Date : 2023-05-04 Alek Erickson, Igor Adameyko
In this issue, Majd et al.1 derive Schwann cells from human pluripotent stem cells (hPSCs), which can be used to study Schwann cell development and physiology and model diabetic neuropathy. hPSC-derived Schwann cells possess the molecular features of primary Schwann cells and are capable of myelination in vitro and in vivo.
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Zooming into finer brain structures in vitro Cell Stem Cell (IF 23.9) Pub Date : 2023-05-04 Ai Zhang, Yanling Wang
Regionalized organoids have recently been developed to resemble a particular brain region. However, generating organoids with even finer sub-regional resolution has proven challenging. In this issue of Cell Stem Cell, Kiral et al.1 report a new organoid model resembling the human ventral thalamus and thalamic reticular nucleus.
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Bioartificial liver with reprogrammed hepatocytes ready for prime time Cell Stem Cell (IF 23.9) Pub Date : 2023-05-04 Ruomeng Li, Asha Balakrishnan, Michael Ott, Amar Deep Sharma
In this issue, Wang et al.1 provide evidence of the pre-clinical as well as the clinical utility of in vitro-generated directly reprogrammed human hepatocytes in bioartificial liver. This approach will help offer patients a more curative surgical therapy for liver cancer and improve survival rates.
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Breathing-induced forces influence lung cell fate Cell Stem Cell (IF 23.9) Pub Date : 2023-05-04 Min-Chi Yang, Martha G. Rea-Moreno, Ya-Wen Chen
Respiration exerts a mechanical strain on the lungs, which has an unclear effect on epithelial cell fate. Now in Cell, Shiraishi et al.1 reveal the crucial role of mechanotransduction in maintaining lung epithelial cell fate, representing a significant milestone in understanding how mechanical factors regulate differentiation.
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Next steps in regenerative medicine Cell Stem Cell (IF 23.9) Pub Date : 2023-05-04 Jun Takahashi
Pluripotent stem cells have opened the gate to cell replacement therapy. As we inch closer to clinical application, we must improve the effectiveness of cell-based therapies. I will discuss the combination of cell transplantation with gene therapy, medication, and rehabilitation to set sight on the next frontier of regenerative medicine.
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Developments in stem cell-derived islet replacement therapy for treating type 1 diabetes Cell Stem Cell (IF 23.9) Pub Date : 2023-05-04 Nathaniel J. Hogrebe, Matthew Ishahak, Jeffrey R. Millman
The generation of islet-like endocrine clusters from human pluripotent stem cells (hPSCs) has the potential to provide an unlimited source of insulin-producing β cells for the treatment of diabetes. In order for this cell therapy to become widely adopted, highly functional and well-characterized stem cell-derived islets (SC-islets) need to be manufactured at scale. Furthermore, successful SC-islet
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Genetic engineering meets hematopoietic stem cell biology for next-generation gene therapy Cell Stem Cell (IF 23.9) Pub Date : 2023-05-04 Samuele Ferrari, Erika Valeri, Anastasia Conti, Serena Scala, Annamaria Aprile, Raffaella Di Micco, Anna Kajaste-Rudnitski, Eugenio Montini, Giuliana Ferrari, Alessandro Aiuti, Luigi Naldini
The growing clinical success of hematopoietic stem/progenitor cell (HSPC) gene therapy (GT) relies on the development of viral vectors as portable “Trojan horses” for safe and efficient gene transfer. The recent advent of novel technologies enabling site-specific gene editing is broadening the scope and means of GT, paving the way to more precise genetic engineering and expanding the spectrum of diseases
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Human pluripotent-stem-cell-derived organoids for drug discovery and evaluation Cell Stem Cell (IF 23.9) Pub Date : 2023-05-04 J. Jeya Vandana, Cassandra Manrique, Lauretta A. Lacko, Shuibing Chen
Human pluripotent stem cells (hPSCs) and three-dimensional organoids have ushered in a new era for disease modeling and drug discovery. Over the past decade, significant progress has been in deriving functional organoids from hPSCs, which have been applied to recapitulate disease phenotypes. In addition, these advancements have extended the application of hPSCs and organoids for drug screening and