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Neural stem cell quiescence and activation dynamics are regulated by feedback input from their progeny under homeostatic and regenerative conditions Cell Stem Cell (IF 19.8) Pub Date : 2025-02-06 Alina Marymonchyk, Raquel Rodriguez-Aller, Ashleigh Willis, Frédéric Beaupré, Sareen Warsi, Marina Snapyan, Valérie Clavet-Fournier, Flavie Lavoie-Cardinal, David R. Kaplan, Freda D. Miller, Armen Saghatelyan
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Cognitive impairment in epilepsy progression: Adult neurogenesis loss at critical window Cell Stem Cell (IF 19.8) Pub Date : 2025-02-06 Yi Wang, Zhong Chen
The mechanisms underlying cognitive impairment in epilepsy remain poorly understood. Ammothumkandy et al.1 reveal that the loss of adult immature neurons correlates with auditory verbal learning deficits in human mesial temporal lobe epilepsy during a critical disease period, underscoring the pivotal role of adult neurogenesis in specific cognitive domain.
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Pre-birth stem cell education: A gift from mother’s bugs Cell Stem Cell (IF 19.8) Pub Date : 2025-02-06 Chenyan Huang, Ai Ing Lim
The maternal gut microbiota undergoes significant changes during pregnancy and plays a pivotal role in offspring development. In this issue, Dang et al. demonstrate that modifying the maternal gut microbiome during pregnancy shapes offspring neural and intestinal stem cells via the mTOR pathway, with long-lasting effects on their functions.
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Human iPSCs offer an alternative for modeling vascular malformation Cell Stem Cell (IF 19.8) Pub Date : 2025-02-06 Stefanie DeFronzo, Guohao Dai
In this issue of Cell Stem Cell, Pan et al. generated human induced pluripotent stem cell (iPSC)-derived venous endothelial cells (iVECs) by manipulating cell-cycle dynamics and Notch signaling and demonstrated that TIE2-mutant iVECs recapitulate the pathogenesis of venous malformations.1 Their study provides a model for further mechanistic studies and drug discovery.
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Two is better than one: Advancing gene therapy protocols for enhanced safety and efficacy Cell Stem Cell (IF 19.8) Pub Date : 2025-02-06 Giulia Hardouin, Annarita Miccio
In this issue of Cell Stem Cell, two complementary studies from Zeng et al.1 and Demirci et al.2 improve the efficacy of gene therapy for β-hemoglobinopathies using multiplex CRISPR-Cas9 editing. The authors also optimize editing and conditioning protocols to reduce risks associated with current gene therapy procedures.
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Molecular signature of primate astrocytes reveals pathways and regulatory changes contributing to human brain evolution Cell Stem Cell (IF 19.8) Pub Date : 2025-02-04 Katarzyna Ciuba, Aleksandra Piotrowska, Debadeep Chaudhury, Bondita Dehingia, Eryk Duński, Rüdiger Behr, Karolina Soroczyńska, Małgorzata Czystowska-Kuźmicz, Misbah Abbas, Edyta Bulanda, Sylwia Gawlik-Zawiślak, Sylwia Pietrzak, Izabela Figiel, Jakub Włodarczyk, Alexei Verkhratsky, Marcin Niedbała, Wojciech Kaspera, Tomasz Wypych, Bartosz Wilczyński, Aleksandra Pękowska
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Adult bi-paternal offspring generated through direct modification of imprinted genes in mammals Cell Stem Cell (IF 19.8) Pub Date : 2025-01-28 Zhi-kun Li, Li-bin Wang, Le-yun Wang, Xue-han Sun, Ze-hui Ren, Si-nan Ma, Yu-long Zhao, Chao Liu, Gui-hai Feng, Tao Liu, Tian-shi Pan, Qing-tong Shan, Kai Xu, Guan-zheng Luo, Qi Zhou, Wei Li
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Genome-wide CRISPR activation screening in senescent cells reveals SOX5 as a driver and therapeutic target of rejuvenation Cell Stem Cell (IF 19.8) Pub Date : 2025-01-28 Yaobin Jing, Xiaoyu Jiang, Qianzhao Ji, Zeming Wu, Wei Wang, Zunpeng Liu, Pedro Guillen-Garcia, Concepcion Rodriguez Esteban, Pradeep Reddy, Steve Horvath, Jingyi Li, Lingling Geng, Qinchao Hu, Si Wang, Juan Carlos Izpisua Belmonte, Jie Ren, Weiqi Zhang, Jing Qu, Guang-Hui Liu
(Cell Stem Cell 30, 1452–1471.e1–e10; November 2, 2023)
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Pluripotent stem-cell-derived therapies in clinical trial: A 2025 update Cell Stem Cell (IF 19.8) Pub Date : 2025-01-25 Agnete Kirkeby, Heather Main, Melissa Carpenter
(Cell Stem Cell 32, 10–37; January 2, 2025)
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Mouse totipotent blastomere-like cells model embryogenesis from zygotic genome activation to post implantation Cell Stem Cell (IF 19.8) Pub Date : 2025-01-17 Bing Peng, Qingyi Wang, Feixiang Zhang, Hui Shen, Peng Du
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Maturation and persistence of CAR T cells derived from human pluripotent stem cells via chemical inhibition of G9a/GLP Cell Stem Cell (IF 19.8) Pub Date : 2025-01-15 Ran Jing, Marcelo Falchetti, Tianxiao Han, Mohamad Najia, Luca T. Hensch, Eleanor Meader, Edroaldo Lummertz da Rocha, Martin Kononov, Stephanie Wang, Trevor Bingham, Zhiheng Li, Yunliang Zhao, Katie Frenis, Caroline Kubaczka, Song Yang, Deepak Jha, Gabriela F. Rodrigues-Luiz, R. Grant Rowe, Thorsten M. Schlaeger, Marcela V. Maus, Trista E. North, Leonard I. Zon, George Q. Daley
(Cell Stem Cell 32, 71–85.e1–e5; January 2, 2025)
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Longitudinal single-cell profiles of lung regeneration after viral infection reveal persistent injury-associated cell states Cell Stem Cell (IF 19.8) Pub Date : 2025-01-15 Terren K. Niethamer, Joseph D. Planer, Michael P. Morley, Apoorva Babu, Gan Zhao, Maria C. Basil, Edward Cantu, David B. Frank, Joshua M. Diamond, Ana N. Nottingham, Shanru Li, Arnav Sharma, Hannah Hallquist, Lillian I. Levin, Su Zhou, Andrew E. Vaughan, Edward E. Morrisey
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Modeling early gastrulation in human blastoids with DNA methylation patterns of natural blastocysts Cell Stem Cell (IF 19.8) Pub Date : 2025-01-14 Han Xie, Chenrui An, Bing Bai, Jiajia Luo, Nianqin Sun, Baiquan Ci, Long Jin, Peiting Mo, Yawen Lu, Ke Zhong, Yang Yu, Tao Tan, Rong Li, Yong Fan
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Ectopic expression of DNMT3L in human trophoblast stem cells restores features of the placental methylome Cell Stem Cell (IF 19.8) Pub Date : 2025-01-08 Georgia Lea, Paula Doria-Borrell, Ana Ferrero-Micó, Anakha Varma, Claire Simon, Holly Anderson, Laura Biggins, Katrien De Clercq, Simon Andrews, Kathy K. Niakan, Lenka Gahurova, Naomi McGovern, Vicente Pérez-García, Courtney W. Hanna
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Engineered hiPSC-derived vascular graft brings hope for thrombosis-free vascular therapy Cell Stem Cell (IF 19.8) Pub Date : 2025-01-02 Soniya Tamhankar, Eric V. Shusta, Sean P. Palecek
Tissue-engineered vascular conduits (TEVCs) are a promising blood vessel replacement. In a recent publication in Cell Stem Cell,1 Park et al. developed TEVCs comprised of decellularized human umbilical arteries lined with shear-trained, human induced pluripotent stem cell (hiPSC)-derived endothelial cells (ECs) that resisted thrombosis and exhibited patency upon grafting into the rat inferior vena
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All-in-one gene therapy alternative for DBAS Cell Stem Cell (IF 19.8) Pub Date : 2025-01-02 Susana Navarro, Paula Río
Diamond-Blackfan anemia syndrome is a ribosomopathy classified among the bone marrow failure syndromes. This disease exhibits significant heterogeneity, with up to 24 genetic variants identified to date. Voit et al.1 present compelling preclinical evidence supporting a universal lentiviral gene therapy strategy to treat patients, regardless of the specific gene involved.
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Perceiving the brain like never before Cell Stem Cell (IF 19.8) Pub Date : 2025-01-02 Sarah Stanley
Editors’ note: The Ogawa-Yamanaka Stem Cell Prize recognizes groundbreaking work in translational regenerative medicine using reprogrammed cells. The prize is supported by Gladstone Institutes, in partnership with Cell Press. Winner of the 2024 Ogawa-Yamanaka Stem Cell Prize Rusty Gage made landmark discoveries that fundamentally shifted the field of neuroscience.
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Pluripotent stem-cell-derived therapies in clinical trial: A 2025 update Cell Stem Cell (IF 19.8) Pub Date : 2025-01-02 Agnete Kirkeby, Heather Main, Melissa Carpenter
Since the first derivation of human pluripotent stem cells (hPSCs) 27 years ago, technologies to control their differentiation and manufacturing have advanced immensely, enabling increasing numbers of clinical trials with hPSC-derived products. Here, we review the landscape of interventional hPSC trials worldwide, highlighting available data on clinical safety and efficacy. As of December 2024, we
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Spatiotemporal single-cell roadmap of human skin wound healing Cell Stem Cell (IF 19.8) Pub Date : 2024-12-26 Zhuang Liu, Xiaowei Bian, Lihua Luo, Åsa K. Björklund, Li Li, Letian Zhang, Yongjian Chen, Lei Guo, Juan Gao, Chunyan Cao, Jiating Wang, Wenjun He, Yunting Xiao, Liping Zhu, Karl Annusver, Nusayhah Hudaa Gopee, Daniela Basurto-Lozada, David Horsfall, Clare L. Bennett, Maria Kasper, Ning Xu Landén
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Different effects of fatty acid oxidation on hematopoietic stem cells based on age and diet Cell Stem Cell (IF 19.8) Pub Date : 2024-12-20 Salma Merchant, Animesh Paul, Amanda Reyes, Daniel Cassidy, Ashley Leach, Dohun Kim, Sarah Muh, Gerik Grabowski, Gerta Hoxhaj, Zhiyu Zhao, Sean J. Morrison
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Gene editing without ex vivo culture evades genotoxicity in human hematopoietic stem cells Cell Stem Cell (IF 19.8) Pub Date : 2024-12-12 Jing Zeng, My Anh Nguyen, Pengpeng Liu, Lucas Ferreira da Silva, Sébastien Levesque, Linda Y. Lin, David G. Justus, Karl Petri, Kendell Clement, Shaina N. Porter, Archana Verma, Nola R. Neri, Tolulope Rosanwo, Marioara-Felicia Ciuculescu, Daniela Abriss, Esther Mintzer, Stacy A. Maitland, Selami Demirci, Hye Ji Cha, Stuart H. Orkin, John F. Tisdale, David A. Williams, Lihua Julie Zhu, Shondra M. Pruett-Miller
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Maternal gut microbiota influence stem cell function in offspring Cell Stem Cell (IF 19.8) Pub Date : 2024-12-11 Haiyue Dang, Panpan Feng, Shuning Zhang, Lihua Peng, Shuli Xing, Yuchen Li, Xiang Wen, Liqiang Zhou, Shyamal Goswami, Mingbing Xiao, Nick Barker, Philippe Sansonetti, Parag Kundu
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Generation of self-organized neuromusculoskeletal tri-tissue organoids from human pluripotent stem cells Cell Stem Cell (IF 19.8) Pub Date : 2024-12-09 Yao Yin, Wei Zhou, Jinkui Zhu, Ziling Chen, Linlin Jiang, Xuran Zhuang, Jia Chen, Jianfeng Wei, Xiaoxiang Lu, Yantong Liu, Wei Pang, Qinzhi Zhang, Yajing Cao, Zhuoya Li, Yuyan Zhu, Yangfei Xiang
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Patient-derived glioblastoma organoids as real-time avatars for assessing responses to clinical CAR-T cell therapy Cell Stem Cell (IF 19.8) Pub Date : 2024-12-09 Meghan Logun, Xin Wang, Yusha Sun, Stephen J. Bagley, Nannan Li, Arati Desai, Daniel Y. Zhang, MacLean P. Nasrallah, Emily Ling-Lin Pai, Bike Su Oner, Gabriela Plesa, Donald Siegel, Zev A. Binder, Guo-li Ming, Hongjun Song, Donald M. O’Rourke
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Fully biologic endothelialized-tissue-engineered vascular conduits provide antithrombotic function and graft patency Cell Stem Cell (IF 19.8) Pub Date : 2024-12-06 Jinkyu Park, Muhammad Riaz, Lingfeng Qin, Wei Zhang, Luke Batty, Saba Fooladi, Mehmet H. Kural, Xin Li, Hangqi Luo, Zhen Xu, Juan Wang, Kimihiko Banno, Sean X. Gu, Yifan Yuan, Christopher W. Anderson, Matthew W. Ellis, Jiahui Zhou, Jiesi Luo, Xiangyu Shi, Jae Hun Shin, Yufeng Liu, Seoyeon Lee, Mervin C. Yoder, Robert W. Elder, Michael Mak, Stephanie Thorn, Albert Sinusas, Peter J. Gruber, John Hwa
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BCL11A +58/+55 enhancer-editing facilitates HSPC engraftment and HbF induction in rhesus macaques conditioned with a CD45 antibody-drug conjugate Cell Stem Cell (IF 19.8) Pub Date : 2024-12-06 Selami Demirci, Jing Zeng, Rahul Palchaudhuri, Chuanfeng Wu, Diana M. Abraham, Taha B. Hayal, Khaled Essawi, My Anh Nguyen, Ulana Stasula, Rebecca Chu, Alexis Leonard, Shaina N. Porter, Muhammad Behroz Naeem Khan, Gabriela Hinojosa, Naoya Uchida, Sogun Hong, Cicera R. Lazzarotto, Nola R. Neri, Lucas Ferreira da Silva, Danilo Pellin, Archana Verma, Leanne Lanieri, Anjali Bhat, Katelyn Hammond, Tiffany
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Straight to the heart: Protecting the patient’s heart during chemotherapy Cell Stem Cell (IF 19.8) Pub Date : 2024-12-05 Rachel Conyers, David A. Elliott
How do we protect the heart during chemotherapy with the anthracycline drug class? Tackling this question, Liu et al. combined pluripotent stem cell models, CRISPR genetic screens, and molecular modeling to identify indisulam as a potential cardioprotective drug in this issue of Cell Stem Cell.
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Preventing radiation and chemo toxicity: Insights from bone marrow-on-a-chip Cell Stem Cell (IF 19.8) Pub Date : 2024-12-05 Milica Radisic
Species-specific differences motivate the development of human hematopoiesis models. Georgescu et al.1 present a microfluidic model of the human bone marrow perivascular niche to capture innate immune cell mobilization. Automated cultivation and high-content analysis for robust insights enabled studies of radiation injury and chemotherapy dosing.
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Brain reboot: Enhancing neurogenesis and resilience Cell Stem Cell (IF 19.8) Pub Date : 2024-12-05 David F. Butler, Andrew S. Yoo
In this issue of Cell Stem Cell, Shen et al. investigate in vivo transient expression of Yamanaka factors (YFs) during embryogenesis and an adult mouse model of Alzheimer’s disease (AD)-associated amyloidosis. These studies demonstrate that transient induction of YFs may be capable of enhancing neurogenesis and offer resilience against neurodegeneration.
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From brain to blood and back again: Linking chronic stress, myelopoiesis, and depression Cell Stem Cell (IF 19.8) Pub Date : 2024-12-05 Ioanna Mosialou, Stavroula Kousteni
In this issue of Cell Stem Cell, Mou et al. identified a brain-bone marrow axis reinforcing myelopoiesis and neuroinflammation during psychological stress, culminating in depression. The identification of this pathway provides insights into hematopoietic stem cell homeostasis and regulatory neuronal function with potentially significant implications for the treatment of stress-related disorders.
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Engineering regional diversity: A morphogen screen for patterned brain organoids Cell Stem Cell (IF 19.8) Pub Date : 2024-12-05 Georgia Panagiotakos, Nan Yang
Morphogens orchestrate cellular diversity during nervous system development, yet a systematic approach to harnessing these signals in stem cell differentiation remains elusive. Amin et al.1 present a platform integrating parallel morphogen modulator screening with single-cell sequencing of neural organoids, reinforcing brain regionalization principles and enabling detailed cellular annotation.
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Stem cell islet replacement in type 1 diabetes: From “shelf” to “self” Cell Stem Cell (IF 19.8) Pub Date : 2024-12-05 Eelco J.P. de Koning, Françoise Carlotti
Recently in Cell, Wang and colleagues1 report the functional cure of a patient with type 1 diabetes after transplantation of autologous, induced pluripotent stem cell (iPSC)-derived islets in the rectus abdominis muscle.
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Making blood from iPSCs: Reaching for the most sought-after prize Cell Stem Cell (IF 19.8) Pub Date : 2024-12-05 Anna Bigas, Gayathri M. Kartha
After many years of little progress, there is now hope for improved in vitro production of hematopoietic stem cells (HSCs). Ng et al.1 have developed defined conditions that allow the generation of HSCs from induced pluripotent stem cells (iPSCs) with unprecedented blood-repopulating capacity.
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Generating human neural diversity with a multiplexed morphogen screen in organoids Cell Stem Cell (IF 19.8) Pub Date : 2024-12-05 Neal D. Amin, Kevin W. Kelley, Konstantin Kaganovsky, Massimo Onesto, Jin Hao, Yuki Miura, James P. McQueen, Noah Reis, Genta Narazaki, Tommy Li, Shravanti Kulkarni, Sergey Pavlov, Sergiu P. Pașca
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Self-organization of the hematopoietic vascular niche and emergent innate immunity on a chip Cell Stem Cell (IF 19.8) Pub Date : 2024-12-05 Andrei Georgescu, Joseph Hai Oved, Jonathan H. Galarraga, Thomas Cantrell, Samira Mehta, Brian M. Dulmovits, Timothy S. Olson, Pouria Fattahi, Anni Wang, Pelin L. Candarlioglu, Asli Muvaffak, Michele M. Kim, Sezin Aday Aydin, Jeongyun Seo, Eric S. Diffenderfer, Anthony Lynch, G. Scott Worthen, Dan Dongeun Huh
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Human adult neurogenesis loss corresponds with cognitive decline during epilepsy progression Cell Stem Cell (IF 19.8) Pub Date : 2024-12-05 Aswathy Ammothumkandy, Luis Corona, Kristine Ravina, Victoria Wolseley, Jeremy Nelson, Nadiya Atai, Aidin Abedi, Nora Jimenez, Michelle Armacost, Lina M. D'Orazio, Virginia Zuverza-Chavarria, Alisha Cayce, Carol McCleary, George Nune, Laura Kalayjian, Darrin J. Lee, Brian Lee, Robert H. Chow, Christianne Heck, Jonathan J. Russin, Charles Y. Liu, Jason A.D. Smith, Michael A. Bonaguidi
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Generation of iPSC-derived human venous endothelial cells for the modeling of vascular malformations and drug discovery Cell Stem Cell (IF 19.8) Pub Date : 2024-11-22 Zihang Pan, Qiyang Yao, Weijing Kong, Xiaojing Ma, Liangliang Tian, Yun Zhao, Shuntian Zhu, Sheng Chen, Mengze Sun, Jiao Liu, Simin Jiang, Jianxun Ma, Qijia Liu, Xiaohong Peng, Xiaoxia Li, Zixuan Hong, Yi Hong, Xue Wang, Jiarui Liu, Jingjing Zhang, Wei Zhang, Bingbing Sun, Sara Pahlavan, Youchen Xia, Weimin Shen, Yuyong Liu, Wenjian Jiang, Zhengwei Xie, Wei Kong, Xi Wang, Kai Wang
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Post-transplant G-CSF impedes engraftment of gene-edited human hematopoietic stem cells by exacerbating p53-mediated DNA damage response Cell Stem Cell (IF 19.8) Pub Date : 2024-11-12 Daisuke Araki, Vicky Chen, Neelam Redekar, Christi Salisbury-Ruf, Yan Luo, Poching Liu, Yuesheng Li, Richard H. Smith, Pradeep Dagur, Christian Combs, Andre Larochelle
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Regulated GATA1 expression as a universal gene therapy for Diamond-Blackfan anemia Cell Stem Cell (IF 19.8) Pub Date : 2024-11-11 Richard A. Voit, Xiaotian Liao, Alexis Caulier, Mateusz Antoszewski, Blake Cohen, Myriam Armant, Henry Y. Lu, Travis J. Fleming, Elena Kamal, Lara Wahlster, Aoife M. Roche, John K. Everett, Angelina Petrichenko, Mei-Mei Huang, William Clarke, Kasiani C. Myers, Craig Forester, Antonio Perez-Atayde, Frederic D. Bushman, Danilo Pellin, Akiko Shimamura, David A. Williams, Vijay G. Sankaran
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All roads lead to cholesterol: Modulating lipid biosynthesis in multiple sclerosis patient-derived models Cell Stem Cell (IF 19.8) Pub Date : 2024-11-07 Sophie Eichhorner, Larissa Traxler, Oliver Borgogno, Jerome Mertens
Studies from Ionescu et al.1 and Clayton et al.2 using multiple sclerosis (MS) patient-derived cell models underscore cholesterol metabolism’s role in inflammatory and dysfunctional cell phenotypes in the disease. Inhibiting cholesterol biosynthesis ameliorated critical cellular phenotypes, emphasizing the need to further investigate this pathway as a potential target for MS treatment.
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Nurturing protectors: Macrophages in the human pancreatic islet Cell Stem Cell (IF 19.8) Pub Date : 2024-11-07 Christopher Z.W. Lee, Francesca M. Spagnoli
Two recent publications in Cell Stem Cell, Yang et al.1 and Migliorini et al.,2 utilized pluripotent stem cell-derived co-culture systems to explore the role of macrophages within the pancreatic islet during development and disease states.
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Trained immunity in the bone marrow: Hub of autoimmunity Cell Stem Cell (IF 19.8) Pub Date : 2024-11-07 Mihai G. Netea, Leo A.B. Joosten
An inappropriate induction of trained immunity in the bone marrow progenitors of immune cells has been described to underlie chronic inflammatory processes. Mills and colleagues’ recently published paper in Cell Stem Cell shows that maladaptive trained immunity drives inflammation in autoimmune processes,1 opening a new area of research in autoimmunity.
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To BE or to PE: Prime editors provide more choices for epitope-editing-based immunotherapy Cell Stem Cell (IF 19.8) Pub Date : 2024-11-07 S.M. Yin, D.L. Li
Epitope editing is a promising strategy for protecting hematopoietic cells from eradication by immunotherapies. Recently, in Cell Stem Cell, Ji et al. applied both base editing (BE) and prime editing (PE) to alter the epitope of CD123 in hematopoietic stem cells for CAR-T therapy against acute myeloid leukemia.1
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Reconsidering the 14-day rule in human embryo research: Advice from the Dutch Health Council Cell Stem Cell (IF 19.8) Pub Date : 2024-11-07 Hafez Ismaili M’hamdi, Guido de Wert
The Dutch Health Council has advised to extend the 14-day rule to 28 days and to subsume integrated stem cell-based embryo models under the same legislative regime as natural embryos. Public discussion is necessary due to the ethical issues that may emerge from studying integrated and non-integrated embryo models.
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CRISPRi/a screens in human iPSC-cardiomyocytes identify glycolytic activation as a druggable target for doxorubicin-induced cardiotoxicity Cell Stem Cell (IF 19.8) Pub Date : 2024-11-07 Chun Liu, Mengcheng Shen, Yanxia Liu, Amit Manhas, Shane Rui Zhao, Mao Zhang, Nadjet Belbachir, Lu Ren, Joe Z. Zhang, Arianne Caudal, Masataka Nishiga, Dilip Thomas, Angela Zhang, Huaxiao Yang, Yang Zhou, Mohamed Ameen, Nazish Sayed, June-Wha Rhee, Lei S. Qi, Joseph C. Wu
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Maturation and persistence of CAR T cells derived from human pluripotent stem cells via chemical inhibition of G9a/GLP Cell Stem Cell (IF 19.8) Pub Date : 2024-11-05 Ran Jing, Marcelo Falchetti, Tianxiao Han, Mohamad Najia, Luca T. Hensch, Eleanor Meader, Edroaldo Lummertz da Rocha, Martin Kononov, Stephanie Wang, Trevor Bingham, Zhiheng Li, Yunliang Zhao, Katie Frenis, Caroline Kubaczka, Song Yang, Deepak Jha, Gabriela F. Rodrigues-Luiz, R. Grant Rowe, Thorsten M. Schlaeger, Marcela V. Maus, Trista E. North, Leonard I. Zon, George Q. Daley
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Microglia depletion reduces human neuronal APOE4-related pathologies in a chimeric Alzheimer’s disease model Cell Stem Cell (IF 19.8) Pub Date : 2024-11-04 Antara Rao, Nuo Chen, Min Joo Kim, Jessica Blumenfeld, Oscar Yip, Zherui Liang, David Shostak, Yanxia Hao, Maxine R. Nelson, Nicole Koutsodendris, Brian Grone, Leo Ding, Seo Yeon Yoon, Patrick Arriola, Misha Zilberter, Yadong Huang
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m6A/YTHDF2-mediated mRNA decay targets TGF-β signaling to suppress the quiescence acquisition of early postnatal mouse hippocampal NSCs Cell Stem Cell (IF 19.8) Pub Date : 2024-10-29 Feng Zhang, Yao Fu, Dennisse Jimenez-Cyrus, Ting Zhao, Yachen Shen, Yusha Sun, Zhijian Zhang, Qing Wang, Riki Kawaguchi, Daniel H. Geschwind, Chuan He, Guo-li Ming, Hongjun Song
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Assembloid models of cell-cell interaction to study tissue and disease biology Cell Stem Cell (IF 19.8) Pub Date : 2024-10-24 Massimo M. Onesto, Ji-il Kim, Sergiu P. Pasca
Neurodevelopment involves the migration, projection, and integration of various cell types across different regions of the nervous system. Assembloids are self-organizing systems formed by the integration of multiple organoids or cell types. Here, we outline the generation and application of assembloids. We illustrate how assembloids recapitulate critical neurodevelopmental steps, like migration, axon
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Vasopressin drives aberrant myeloid differentiation of hematopoietic stem cells, contributing to depression in mice Cell Stem Cell (IF 19.8) Pub Date : 2024-10-22 Rong Mou, Junkai Ma, Xuan Ju, Yixin Wu, Qiuli Chen, Jinglin Li, Tongyao Shang, Siying Chen, Yue Yang, Yue Li, Kaosheng Lv, Xuequn Chen, Qi Zhang, Tingbo Liang, Ye Feng, Xinjiang Lu
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Generation of human expandable limb-bud-like progenitors via chemically induced dedifferentiation Cell Stem Cell (IF 19.8) Pub Date : 2024-10-22 Jialiang Zhu, Xinxing Zhong, Huanjing He, Jingxiao Cao, Zhengyang Zhou, Jiebin Dong, Honggang Li, Anqi Zhang, Yulin Lyu, Cheng Li, Jingyang Guan, Hongkui Deng
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Photo-tunable hydrogels reveal cellular sensing of rapid rigidity changes through the accumulation of mechanical signaling molecules Cell Stem Cell (IF 19.8) Pub Date : 2024-10-21 Jiapeng Yang, Peng Wang, Yu Zhang, Man Zhang, Qian Sun, Huiyan Chen, Liang Dong, Zhiqin Chu, Bin Xue, Wouter David Hoff, Changsheng Zhao, Wei Wang, Qiang Wei, Yi Cao
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Increased cholesterol synthesis drives neurotoxicity in patient stem cell-derived model of multiple sclerosis Cell Stem Cell (IF 19.8) Pub Date : 2024-10-21 Rosana-Bristena Ionescu, Alexandra M. Nicaise, Julie A. Reisz, Eleanor C. Williams, Pranathi Prasad, Cory M. Willis, Madalena B.C. Simões-Abade, Linda Sbarro, Monika Dzieciatkowska, Daniel Stephenson, Marta Suarez Cubero, Sandra Rizzi, Liviu Pirvan, Luca Peruzzotti-Jametti, Valentina Fossati, Frank Edenhofer, Tommaso Leonardi, Christian Frezza, Irina Mohorianu, Angelo D’Alessandro, Stefano Pluchino
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Expansion of the neocortex and protection from neurodegeneration by in vivo transient reprogramming Cell Stem Cell (IF 19.8) Pub Date : 2024-10-18 Yi-Ru Shen, Sofia Zaballa, Xavier Bech, Anna Sancho-Balsells, Irene Rodríguez-Navarro, Carmen Cifuentes-Díaz, Gönül Seyit-Bremer, Seung Hee Chun, Tobias Straub, Jordi Abante, Iñaki Merino-Valverde, Laia Richart, Vipul Gupta, Hao-Yi Li, Ivan Ballasch, Noelia Alcázar, Jordi Alberch, Josep M. Canals, Maria Abad, Manuel Serrano, Rüdiger Klein, Albert Giralt, Daniel del Toro
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Mitochondrial pyruvate carriers control airway basal progenitor cell function through glycolytic-epigenetic reprogramming Cell Stem Cell (IF 19.8) Pub Date : 2024-10-18 Yawen Li, Yalin He, Qi Zheng, Jiazhu Zhang, Xinwen Pan, Xi Zhang, Huairui Yuan, Guangchuan Wang, Xin Liu, Xiaolong Zhou, Xueliang Zhu, Tao Ren, Pengfei Sui
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A distinct metabolic and epigenetic state drives trained immunity in HSC-derived macrophages from autoimmune mice Cell Stem Cell (IF 19.8) Pub Date : 2024-10-15 Taylor S. Mills, Bailee Kain, Matt A. Burchill, Etienne Danis, Erin D. Lucas, Rachel Culp-Hill, Courtney M. Cowan, Wolfgang E. Schleicher, Sweta B. Patel, Brandon T. Tran, Ruoqiong Cao, Andrew Goodspeed, Sarah Ferrara, Shaun Bevers, Beth A. Jirón Tamburini, James R. Roede, Angelo D’Alessandro, Katherine Y. King, Eric M. Pietras
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Embryonic macrophages support endocrine commitment during human pancreatic differentiation Cell Stem Cell (IF 19.8) Pub Date : 2024-10-14 Adriana Migliorini, Sabrina Ge, Michael H. Atkins, Amanda Oakie, Rangarajan Sambathkumar, Gregory Kent, Haiyang Huang, Angel Sing, Conan Chua, Adam J. Gehring, Gordon M. Keller, Faiyaz Notta, Maria Cristina Nostro
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Common and uncommon findings in marmoset and human trophoblast stem cells Cell Stem Cell (IF 19.8) Pub Date : 2024-10-03 Hiroaki Okae, Shun Shibata, Takahiro Arima
In this issue of Cell Stem Cell, Siriwardena et al. analyze peri- and post-implantation marmoset trophoblast development in detail and establish marmoset trophoblast stem cell (TSC) lines from pluripotent stem cells (PSCs). Comparative analysis of marmoset and human TSCs provides insights into species-specific implantation and placentation strategies.
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Let’s get functional: Drug sensitivity profiling to enable precision sarcoma medicine Cell Stem Cell (IF 19.8) Pub Date : 2024-10-03 Claudia R. Ball, Stefan Fröhling
Drug sensitivity profiling in patient-derived tumor models offers new hope for improving outcomes in cancers lacking effective therapies. Al Shihabi et al.1 demonstrate that short-term cultures from bone and soft tissue sarcomas enable clinically meaningful screening of multiple drugs and combinations, marking a significant advance in personalized care for these high-risk diseases.
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Charles “Chuck” K.F. Chan (1975–2024) Cell Stem Cell (IF 19.8) Pub Date : 2024-10-03 Thomas H. Ambrosi, Michael T. Longaker
Download: Download high-res image (353KB) Download: Download full-size image Charles K.F. ChanChuck Chan dedicated his life to unraveling the mysteries of bone marrow niches and was the first to define and characterize a mouse and human skeletal stem cell lineage (SSC) tree. He was a brilliant scientist whose pioneering work in stem cell research has left an indelible mark on the field. His journey