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Proteomic and interactomic insights into the molecular basis of cell functional diversity Nat. Rev. Mol. Cell Biol. (IF 43.351) Pub Date : 2020-03-31 Isabell Bludau; Ruedi Aebersold
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Reactive oxygen species (ROS) as pleiotropic physiological signalling agents Nat. Rev. Mol. Cell Biol. (IF 43.351) Pub Date : 2020-03-30 Helmut Sies; Dean P. Jones
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DNA 6mA in times of mitochondrial stress Nat. Rev. Mol. Cell Biol. (IF 43.351) Pub Date : 2020-03-26 Joseph Willson
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The functions of short ORFs and their microproteins Nat. Rev. Mol. Cell Biol. (IF 43.351) Pub Date : 2020-03-24 Eytan Zlotorynski
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Foundations of ER-phagy regulation Nat. Rev. Mol. Cell Biol. (IF 43.351) Pub Date : 2020-03-17 Paulina Strzyz
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Lipids as the key to understanding α-synuclein behaviour in Parkinson disease Nat. Rev. Mol. Cell Biol. (IF 43.351) Pub Date : 2020-03-16 Roni Stok; Avraham Ashkenazi
Parkinson disease is a devastating neurodegenerative condition that is characterized by intraneuronal toxic assemblies of the α-synuclein protein. In this Comment, we discuss the emerging role of lipids in understanding biology as well as in the identification of new therapeutic targets in this disease. Avraham Ashkenazi draws attention to the role of lipids in the pathology of Parkinson disease.
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Cellular adaptation to hypoxia through hypoxia inducible factors and beyond Nat. Rev. Mol. Cell Biol. (IF 43.351) Pub Date : 2020-03-06 Pearl Lee; Navdeep S. Chandel; M. Celeste Simon
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The tubulin code and its role in controlling microtubule properties and functions. Nat. Rev. Mol. Cell Biol. (IF 43.351) Pub Date : 2020-02-27 Carsten Janke,Maria M Magiera
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The antitumorigenic roles of BRCA1–BARD1 in DNA repair and replication Nat. Rev. Mol. Cell Biol. (IF 43.351) Pub Date : 2020-02-24 Madalena Tarsounas; Patrick Sung
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Towards attaining a quantitative and mechanistic model of a cell. Nat. Rev. Mol. Cell Biol. (IF 43.351) Pub Date : 2020-02-21 Guillaume Diss
Mutations cause phenotypic changes by perturbing the organization of molecular networks and the functions that emerge from these networks. A model of a cell based on molecular interactions will be required in order to understand the molecular mechanisms underlying complex traits. Mutations perturb molecular networks; thus, a model of molecular interactions will be required to fully understand complex
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Defective mitochondria ignite the SASP. Nat. Rev. Mol. Cell Biol. (IF 43.351) Pub Date : 2020-02-19 Eytan Zlotorynski
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The cell biology of mitochondrial membrane dynamics. Nat. Rev. Mol. Cell Biol. (IF 43.351) Pub Date : 2020-02-18 Marta Giacomello,Aswin Pyakurel,Christina Glytsou,Luca Scorrano
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Looking deeper into tissue elongation. Nat. Rev. Mol. Cell Biol. (IF 43.351) Pub Date : 2020-02-18 Audrey M Williams,Sally Horne-Badovinac
In this Journal Club, Audrey Williams and Sally Horne-Badovinac highlight the importance of studying the basal cell surface and its dynamics to understand epithelial cell behaviours and tissue rearrangements.
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Target gene-independent functions of MYC oncoproteins. Nat. Rev. Mol. Cell Biol. (IF 43.351) Pub Date : 2020-02-18 Apoorva Baluapuri,Elmar Wolf,Martin Eilers
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Stress fibres fuel glycolysis. Nat. Rev. Mol. Cell Biol. (IF 43.351) Pub Date : 2020-02-14 Joseph Willson
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Conserved assembly of polarity complexes. Nat. Rev. Mol. Cell Biol. (IF 43.351) Pub Date : 2020-02-10 Kim Baumann
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Membrane and organelle dynamics during cell division. Nat. Rev. Mol. Cell Biol. (IF 43.351) Pub Date : 2020-02-07 Jeremy G Carlton,Hannah Jones,Ulrike S Eggert
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The ageing epigenome and its rejuvenation. Nat. Rev. Mol. Cell Biol. (IF 43.351) Pub Date : 2020-02-04 Weiqi Zhang,Jing Qu,Guang-Hui Liu,Juan Carlos Izpisua Belmonte
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Regulation of long non-coding RNAs and genome dynamics by the RNA surveillance machinery. Nat. Rev. Mol. Cell Biol. (IF 43.351) Pub Date : 2020-02-04 Lekha Nair,Hachung Chung,Uttiya Basu
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Publisher Correction: Locus-specific chromatin isolation. Nat. Rev. Mol. Cell Biol. (IF 43.351) Pub Date : 2020-02-03 Michiel Vermeulen,Jérôme Déjardin
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Author Correction: mTOR at the nexus of nutrition, growth, ageing and disease. Nat. Rev. Mol. Cell Biol. (IF 43.351) Pub Date : 2020-01-31 Grace Y Liu,David M Sabatini
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Regulatory R-loops as facilitators of gene expression and genome stability. Nat. Rev. Mol. Cell Biol. (IF 43.351) Pub Date : 2020-01-31 Christof Niehrs,Brian Luke
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The mitochondrial tRNA conundrum. Nat. Rev. Mol. Cell Biol. (IF 43.351) Pub Date : 2020-01-30 Lluís Ribas de Pouplana
Lluís Ribas de Pouplana outlines the unanswered questions of mitochondrial transcription.
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Chromatin plasticity eXISTs in differentiated cells. Nat. Rev. Mol. Cell Biol. (IF 43.351) Pub Date : 2020-01-30 Minju Ha
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Locus-specific chromatin isolation. Nat. Rev. Mol. Cell Biol. (IF 43.351) Pub Date : 2020-01-29 Michiel Vermeulen,Jérôme Déjardin
Identifying factors bound to specific genomic loci in an unbiased manner is the holy grail of chromatin research, because it would provide an ultimate description of locus function. In this Comment, we explain why purifying a single locus represents a major technical challenge and provide recommendations for achieving this goal. Michiel Vermeulen and Jérôme Déjardin recommend how best to characterize
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When cellular forces became visible. Nat. Rev. Mol. Cell Biol. (IF 43.351) Pub Date : 2020-01-23 Xavier Trepat
Xavier Trepat highlights the first approach to measurement of forces exerted by cells
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mtDNA in the crossroads of evolution and disease. Nat. Rev. Mol. Cell Biol. (IF 43.351) Pub Date : 2020-01-22 Dan Mishmar
Dan Mishmar recounts the first studies that used mitochondrial DNA (mtDNA) to trace the origin of humanity to Africa and that connected mtDNA mutations with a human disease.
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Lipid transfer at ER-isolation membrane contacts. Nat. Rev. Mol. Cell Biol. (IF 43.351) Pub Date : 2020-01-15 Hong Zhang
Hong Zhang highlights the emerging importance of lipid transfer proteins in autophagosome biogenesis.
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mTOR at the nexus of nutrition, growth, ageing and disease. Nat. Rev. Mol. Cell Biol. (IF 43.351) Pub Date : 2020-01-14 Grace Y Liu,David M Sabatini
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Collagen around the clock. Nat. Rev. Mol. Cell Biol. (IF 43.351) Pub Date : 2020-01-13 Paulina Strzyz
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Plant gene editing improved. Nat. Rev. Mol. Cell Biol. (IF 43.351) Pub Date : 2019-12-30 Kim Baumann
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The other face of PIWI. Nat. Rev. Mol. Cell Biol. (IF 43.351) Pub Date : 2019-12-23 Eytan Zlotorynski
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Viral infection linked to m6A alterations in host mRNAs. Nat. Rev. Mol. Cell Biol. (IF 43.351) Pub Date : 2019-12-18 Caroline Barranco
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Transcription boosting by nuclear speckles. Nat. Rev. Mol. Cell Biol. (IF 43.351) Pub Date : 2019-12-17 Minju Ha
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Mechanisms and regulation of cholesterol homeostasis. Nat. Rev. Mol. Cell Biol. (IF 43.351) Pub Date : 2019-12-17 Jie Luo,Hongyuan Yang,Bao-Liang Song
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Rise of the neglected repeats RNA. Nat. Rev. Mol. Cell Biol. (IF 43.351) Pub Date : 2019-12-16 Marianne Farnebo
Marianne Farnebo describes how the application of microscopy techniques has provided valuable information on repeats RNAs.
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A matter of life and death for caspase 8. Nat. Rev. Mol. Cell Biol. (IF 43.351) Pub Date : 2019-12-16 Joseph Willson
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Human cohesin extrudes interphase DNA to make loops. Nat. Rev. Mol. Cell Biol. (IF 43.351) Pub Date : 2020-01-01 Kim Baumann
Cohesin is reported to form DNA loops in interphase chromatin by a mechanism of DNA loop extrusion.
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Molecular mechanisms and physiological importance of circadian rhythms. Nat. Rev. Mol. Cell Biol. (IF 43.351) Pub Date : 2019-11-25 Alina Patke,Michael W Young,Sofia Axelrod
To accommodate daily recurring environmental changes, animals show cyclic variations in behaviour and physiology, which include prominent behavioural states such as sleep-wake cycles but also a host of less conspicuous oscillations in neurological, metabolic, endocrine, cardiovascular and immune functions. Circadian rhythmicity is created endogenously by genetically encoded molecular clocks, whose
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Integrator of stress cues. Nat. Rev. Mol. Cell Biol. (IF 43.351) Pub Date : 2020-01-01 Marzia Munafò
The Integrator complex fine-tunes mRNA levels in response to stress by attenuating productive transcription elongation
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Lysosomes as dynamic regulators of cell and organismal homeostasis. Nat. Rev. Mol. Cell Biol. (IF 43.351) Pub Date : 2019-11-25 Andrea Ballabio,Juan S Bonifacino
Exciting new discoveries have transformed the view of the lysosome from a static organelle dedicated to the disposal and recycling of cellular waste to a highly dynamic structure that mediates the adaptation of cell metabolism to environmental cues. Lysosome-mediated signalling pathways and transcription programmes are able to sense the status of cellular metabolism and control the switch between anabolism
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Mitosis flips the switch on autophagy control. Nat. Rev. Mol. Cell Biol. (IF 43.351) Pub Date : 2020-01-01 Joseph Willson
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The molecular principles governing the activity and functional diversity of AAA+ proteins. Nat. Rev. Mol. Cell Biol. (IF 43.351) Pub Date : 2019-11-21 Cristina Puchades,Colby R Sandate,Gabriel C Lander
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Iron expulsion by exosomes drives ferroptosis resistance. Nat. Rev. Mol. Cell Biol. (IF 43.351) Pub Date : 2020-01-01 Paulina Strzyz
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The regulation, functions and clinical relevance of arginine methylation. Nat. Rev. Mol. Cell Biol. (IF 43.351) Pub Date : 2019-07-26 Ernesto Guccione,Stéphane Richard
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Extracellular vesicles: a new communication paradigm? Nat. Rev. Mol. Cell Biol. (IF 43.351) Pub Date : 2019-09-01 Graça Raposo,Philip D Stahl
Biological information can be shared between cells via extracellular vesicles. However, how cargo carried by extracellular vesicles elicits biological responses remains unresolved. Deciphering the molecular mechanisms that govern packaging and targeted delivery of extracellular vesicle cargo will be required to establish extracellular vesicles as important signalling entities. Stahl and Raposo discuss
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Tying lipid rafts to oncogenic signalling. Nat. Rev. Mol. Cell Biol. (IF 43.351) Pub Date : 2019-09-01 Paulina Strzyz
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Histone methylation boosts liver regeneration. Nat. Rev. Mol. Cell Biol. (IF 43.351) Pub Date : 2019-08-01 Eytan Zlotorynski
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The importance of non-histone protein methylation in cancer therapy. Nat. Rev. Mol. Cell Biol. (IF 43.351) Pub Date : 2019-10-01 Manuel Rodríguez-Paredes,Frank Lyko
Epigenetic regulatory enzymes are generally considered innovative targets for cancer therapy and several histone methyltransferase inhibitors are currently being evaluated in phase I and phase II clinical trials. In this commentary, we discuss the need for better functional understanding of histone methyltransferases and especially of their potential non-histone substrates. Rodríguez-Paredes and Lyko
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The roles of DNA, RNA and histone methylation in ageing and cancer. Nat. Rev. Mol. Cell Biol. (IF 43.351) Pub Date : 2019-07-03 Ewa M Michalak,Marian L Burr,Andrew J Bannister,Mark A Dawson
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Roles and regulation of histone methylation in animal development. Nat. Rev. Mol. Cell Biol. (IF 43.351) Pub Date : 2019-07-02 Ashwini Jambhekar,Abhinav Dhall,Yang Shi
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Author Correction: Functions and mechanisms of non-histone protein acetylation Nat. Rev. Mol. Cell Biol. (IF 43.351) Pub Date : 2019-07-02 Takeo Narita, Brian T. Weinert, Chunaram Choudhary
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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DNA double-strand break repair-pathway choice in somatic mammalian cells. Nat. Rev. Mol. Cell Biol. (IF 43.351) Pub Date : 2019-07-01 Ralph Scully,Arvind Panday,Rajula Elango,Nicholas A Willis
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The Hsp70 chaperone network. Nat. Rev. Mol. Cell Biol. (IF 43.351) Pub Date : 2019-11-01 Rina Rosenzweig,Nadinath B Nillegoda,Matthias P Mayer,Bernd Bukau
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Cellular crosstalk in the development and regeneration of the respiratory system. Nat. Rev. Mol. Cell Biol. (IF 43.351) Pub Date : 2019-06-19 Jarod A Zepp,Edward E Morrisey
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Translating the right way Nat. Rev. Mol. Cell Biol. (IF 43.351) Pub Date : 2019-06-14 Gordon Carmichael
Early in his career, Gordon Carmichael was inspired by the contradictory conclusions of three articles.
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The role of 3D genome organization in development and cell differentiation. Nat. Rev. Mol. Cell Biol. (IF 43.351) Pub Date : 2019-09-01 Hui Zheng,Wei Xie
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