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Lasker Award for AlphaFold Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-09-26 Paulina Strzyz
Congratulations to John Jumper and Demis Hassabis for winning the 2023 Albert Lasker Basic Medical Research Award.
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Author Correction: The molecular basis of nutrient sensing and signalling by mTORC1 in metabolism regulation and disease Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-09-26 Claire Goul, Roberta Peruzzo, Roberto Zoncu
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A quick guide to (transmembrane) planar cell polarity mouse strains Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-09-25 Sarah V. Paramore
In this Tools of the Trade article, Sarah Paramore (from the Devenport and Nelson labs) discusses the use of mouse strains carrying genomic alterations in PCP genes and how they can increase our understanding of mammalian planar cell polarity.
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Understanding mechanisms of antioxidant action in health and disease Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-09-15 Barry Halliwell
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FOXO transcription factors as mediators of stress adaptation Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-09-14 Maria J. Rodriguez-Colman, Tobias B. Dansen, Boudewijn. M. T. Burgering
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Alternative to lysosomal degradation: mitochondrial removal via EVs Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-09-11 Paulina Strzyz
Liang et al. show that mitochondria can be expelled from cells via extracellular vesicles as a route of quality control that is an alternative to lysosomal degradation.
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The discovery of simple repeats that cause complex disorders Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-09-11 Jeannine Gerhardt
Two papers published in 1991 established a new class of human genetic disorders, caused by expansion of simple DNA repeats.
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Smelling your way to longevity Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-09-11 Patricija van Oosten-Hawle
The first study to show, in C. elegans, that sensory neurons have a role in lifespan regulation.
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Transcription factors crossing the cell membrane Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-09-11 Jin Woo Kim
Antennapedia proteins were among the first proteins found to be exchanged intercellularly. This discovery by Alain Prochiantz and colleagues has inspired researchers of various backgrounds.
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Mechanisms and pathology of protein misfolding and aggregation Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-09-08 Nikolaos Louros, Joost Schymkowitz, Frederic Rousseau
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The double-edged sword of bivalency Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-09-05 Aydan Bulut-Karslıoğlu
Bulut-Karslıoğlu remembers the publication of two seminal papers that described bivalent chromatin and how this discovery continues to affect research to this day.
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STINGing through the membrane to channel protons Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-08-29 Lisa Heinke
To activate noncanonical LC3B lipidation and NLRP3 inflammasome formation, stimulator of interferon genes (STING) forms a proton channel in Golgi membranes.
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The neuronal epigenome is special Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-08-29 Anne E. West
Anne West recounts the study that showed postnatal accumulation of non-CpG DNA methylation in neurons coinciding with postnatal synapse maturation, suggesting that it contributes to brain function.
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The translation m(o)TOR that propels regeneration Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-08-29 Eytan Zlotorynski
In the amphibian axolotl, the kinase mTOR is hyper-sensitive and activates a protein synthesis response that is crucial for wound healing and tissue regeneration.
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Control of stem cell renewal and fate by YAP and TAZ Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-08-25 Jordan H. Driskill, Duojia Pan
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Genetic wrinkles in time Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-08-24 Ronald Cutler, Jan Vijg
Cutler and Vijg remind us of the publication that laid the foundation for genetic mutation theories of ageing.
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The molecular basis of nutrient sensing and signalling by mTORC1 in metabolism regulation and disease Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-08-23 Claire Goul, Roberta Peruzzo, Roberto Zoncu
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Publisher Correction: Reading, writing and erasing mRNA methylation Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-08-21 Sara Zaccara, Ryan J. Ries, Samie R. Jaffrey
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Unbiased mapping of protein trafficking with TransitID Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-08-21 Joleen S. Cheah
In this Tools of the Trade article, Joleen Cheah (from the Ting lab) discusses the development of TransitID, which allows researchers to capture protein trafficking pathways in vivo without a priori knowledge of specific proteins of interest.
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Context-dependent TGFβ family signalling in cell fate regulation Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-08-18 Louise Richardson, Scott G. Wilcockson, Luca Guglielmi, Caroline S. Hill
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RNF26 and vimentin orchestrate ER stress recovery Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-08-17 Paulina Strzyz
Cremer et al. show that the ubiquitin ligase RNF26 and vimentin-based intermediate filaments cooperate to control perinuclear ER membrane organization and thus facilitate recovery from ER stress.
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Has translation in the nucleus found its purpose? Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-08-17 Robin Fåhraeus
Translation in the nucleus is a long-standing controversial issue with unclear physiological importance. Recent studies show that antigenic peptides for immune tolerance are derived from translation initiated at non-AUG codons of precursor mRNAs in the nucleus. It is therefore time to take a fresh look at nuclear translation and its interesting implications. Recent studies show that antigenic peptides
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Roles of RIPK1 as a stress sentinel coordinating cell survival and immunogenic cell death Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-08-11 Jarama Clucas, Pascal Meier
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Mechanisms of substrate processing during ER-associated protein degradation Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-08-01 John C. Christianson, Ernst Jarosch, Thomas Sommer
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Structural and functional complexity of HSP90 in cellular homeostasis and disease Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-07-31 Gabriela Chiosis, Chander S. Digwal, Jane B. Trepel, Len Neckers
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Harnessing fluorescent probes to unveil dynamic membrane mechanics Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-07-26 Chloé Roffay, Vincent Mercier
In this Tools of the Trade article, Roffay and Mercier (from the Roux lab) describe the development of fluorescent Flipper probes that allow measurement of membrane mechanics in vivo.
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Biology and therapeutic targeting of vascular endothelial growth factor A Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-07-25 Lorena Pérez-Gutiérrez, Napoleone Ferrara
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May the force be with microtubules Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-07-20 Lisa Heinke
Cycles of stretch and compression, such as during cell migration through tissues, lead to stabilization of microtubules owing to redistribution of the plus-end-binding protein CLASP2 along microtubule lengths.
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RNA binding — a useful third wheel in transcription Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-07-20 Eytan Zlotorynski
Transcription factors bind RNA through an Arg-rich motif; these interactions potentially promote transcription and development, and their dissociation can contribute to disease.
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Cellular functions of eukaryotic RNA helicases and their links to human diseases Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-07-20 Katherine E. Bohnsack, Soon Yi, Sarah Venus, Eckhard Jankowsky, Markus T. Bohnsack
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Myosin VI assists in fork protection Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-07-12 Paulina Strzyz
Shi et al. show the role of myosin VI in the protection of stalled replication forks during replication stress.
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Mechanisms of BCL-2 family proteins in mitochondrial apoptosis Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-07-12 Peter E. Czabotar, Ana J. Garcia-Saez
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How embryos sort themselves out Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-07-10 Diana Pinheiro
Diana Pinheiro recounts two seminal papers describing how cell surface tension dictates how cells sort into different tissues during development.
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Internal-m7G-modified mRNAs quake under stress Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-07-04 Eytan Zlotorynski
During cellular stresses, the mRNA internal 7-methylguanosine (m7G) modification is bound by QKI-7, which regulates the stability and/or translation of the mRNAs by sequestering them in stress granules.
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Integrated biophysical imaging of cell interactions with 3D extracellular matrices Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-07-04 William Leineweber
In this Tools of the Trade article, William Leineweber (from the Fraley lab) describes the set-up of an integrated biophysical imaging platform that allows researchers to assess the interactions between cells and the surrounding extracellular matrix.
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Tightening the epithelium to control signalling Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-07-03 Lisa Heinke
The tight junction protein TJP1 is essential for controlling BMP signalling during patterning of human gastrulation models.
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Regulation and functions of non-m6A mRNA modifications Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-06-27 Hanxiao Sun, Kai Li, Cong Liu, Chengqi Yi
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Publisher Correction: The multiple links between actin and mitochondria. Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-06-28 Tak Shun Fung,Rajarshi Chakrabarti,Henry N Higgs
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Transfection reflections: fit-for-purpose delivery of nucleic acids Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-06-21 Chris Wells-Holland, Alistair Elfick
Transfection is a foundational technology in biosciences, biotechnology, and the development of biotherapeutic agents. Given its transcendence, it is problematic that transfection remains a poorly understood and insufficiently characterized endeavour. Here we state the case for the urgent reworking of transfection as a fit-for-purpose technological foundation for the ambitions of scientists and engineers
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Deciphering ADP-ribosylation signalling Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-06-21 Edoardo José Longarini, Helen Dauben
In this Tools of the Trade article, Edoardo José Longarini and Helen Dauben (from the Matić lab) describe the development and applications of mono-ADP-ribosylation antibodies and peptides.
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Hypoxia prevents premature ageing in mice Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-06-08 Paulina Strzyz
Rogers et al. provide evidence that hypoxia is beneficial in mammalian ageing, extending the lifespan of prematurely ageing mice.
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The technological landscape and applications of single-cell multi-omics Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-06-06 Alev Baysoy, Zhiliang Bai, Rahul Satija, Rong Fan
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SWI/SNF chromatin remodellers persist through mitosis Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-06-05 Eytan Zlotorynski
Subunits of the SWI/SNF chromatin remodelling complexes ‘bookmark’ cell-type specifying genes during mitosis to allow their timely reactivation upon mitosis exit.
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The multiple links between actin and mitochondria Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-06-05 Tak Shun Fung, Rajarshi Chakrabarti, Henry N. Higgs
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Studying lysosomal function and dysfunction using LysoIP Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-05-26 Nouf N. Laqtom
In this Tools of the Trade article, Nouf Laqtom (at the Abu-Remaileh lab) describes the LysoIP system used to tag and isolate lysosomes for multi-omic approaches and to determine their composition under physiological and pathological states.
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New frontiers in quality control: the case of GPI-anchored proteins Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-05-25 Leticia Lemus, Ramanujan S. Hegde, Veit Goder
The biosynthesis and trafficking of glycosylphosphatidylinositol-anchored proteins (GPI-APs), many of enormous clinical importance, are complex multistep processes involving dozens of dedicated factors. Recent work indicates that the quality control of GPI-APs is similarly complex, varying substantially between different eukaryotic species and relying on several previously unknown cellular mechanisms
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Genome control by SMC complexes Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-05-25 Claire Hoencamp, Benjamin D. Rowland
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Exercise metabolism and adaptation in skeletal muscle Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-05-24 Jonathon A. B. Smith, Kevin A. Murach, Kenneth A. Dyar, Juleen R. Zierath
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oskar switches motors halfway through its journey Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-05-23 Lisa Heinke
Transport of the developmental mRNA oskar to its destination at the posterior pole of the Drosophila embryo relies on the two dsRNA-binding proteins Egalitarian and Staufen that promote switching between the motor proteins dynein and kinesin.
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Orchestration of skin stem cell layer by calcium signals Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-05-12 Paulina Strzyz
A new study collaboratively delivered by Valentina Greco’s and Smita Krishnaswamy’s labs provides new insight into patterns of calcium signalling in epithelial tissues using intravital imaging of the basal layer of the mouse epidermis.
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Genome doubling — twice the same is not the same Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-05-12 Zuzana Storchová
Zuzana Storchová recounts the discovery of the subtle yet significant consequences of polyploidy.
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CTCF works better under tension Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-05-09 Lisa Heinke
The eukaryotic genome is organized into topologically associating domains by cohesin and CTCF. Davidson et al. now reveal a role for DNA tension in the regulation of the CTCF–cohesin interaction to modulate domain boundaries.
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The contribution of databases towards understanding the universe of long non-coding RNAs Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-05-05 Lina Ma, Zhang Zhang
Numerous various databases worldwide collate information on the growing number of long non-coding RNAs (lncRNAs) that have been extensively characterized in several species. In this Comment, we overview the types and features of lncRNA databases, and discuss their contribution to facing challenges and seizing opportunities in lncRNA research. Numerous databases collate data on long non-coding RNAs
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Radical recovery from radiation Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-05-04 Betsabel Chicana, Christina Marie Termini
The discovery that peripheral organs such as the spleen support blood formation following radiation has inspired haematology research for over five decades.
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Regulation of phospholipid distribution in the lipid bilayer by flippases and scramblases Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-04-27 Takaharu Sakuragi, Shigekazu Nagata
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Identification of metabolic networks by genetic co-essentiality analysis Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-04-26 Benjamin T. Jackson
In this Tools of the Trade article, Benjamin Jackson (at the Finley lab) describes the use of genetic co-essentiality analysis to interrogate the assembly of metabolic networks, fuelling discovery of new aspects of metabolism.
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Cold-induced longevity through proteasome boosting Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-04-25 Eytan Zlotorynski
Cold temperature prolongs lifespan in nematodes by inducing ubiquitin-independent proteasome activity, which prevents protein aggregation and neuronal degeneration. The pathway is conserved in humans.
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Tuning BCR signalling at lipid rafts Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-04-24 Paulina Strzyz
Shelby et al. demonstrate the existence of discrete domains in plasma membranes of B cells that selectively partition membrane-associated proteins.
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Heterochromatin definition and function Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-04-17 Oliver Bell, Adam Burton, Caroline Dean, Susan M. Gasser, Maria-Elena Torres-Padilla
Heterochromatin is a key characteristic of eukaryotic genomes. Since its cytological description nearly 100 years ago, our understanding of heterochromatin features and functions, including transcription repression and genome stability, have continuously evolved. In this Viewpoint article, experts provide their current opinions on heterochromatin definition, types and functional mechanisms. In this
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A nascent interest amplified Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-04-13 Thoru Pederson
Thoru Pederson recalls the impact that a 1968 paper from Dan Brown’s lab had on his career.