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Homeostasis control in health and disease by the unfolded protein response Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-11-05 Diego Acosta-Alvear, Jonathan M. Harnoss, Peter Walter, Avi Ashkenazi
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Epigenetic discovery by enzyme activity profiling Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-10-25 Manini S. Penikalapati, Jordan L. Meier
C. David Allis’s discovery of the first histone acetyltransferase from Tetrahymena exemplifies an approach that continues to evolve and now has a crucial role in drug development.
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When senescence generates pluripotent stem cells Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-10-24 Miria Ricchetti
Senescent cells in the amputated head of the cnidarian Hydractinia symbiolongicarpus drive the reprogramming of somatic cells into pluripotent stem cells, which are required for full body regeneration.
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The double-edged sword of eliminating senescent cells Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-10-24 Eric Gilson
Removal of different types of senescent cells can be either beneficial or detrimental to health, with potential consequences to senotherapies.
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A nuclear morphology-based machine learning algorithm for senescence detection Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-10-23 Imanol Duran
In this Tools of the Trade article, Duran (Gil lab) describes the development of novel machine learning algorithms that enable the detection of senescent cells in vitro and in diverse tissues based solely on nuclear morphologeny analysis.
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The prompt to discover senolytics Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-10-23 James L. Kirkland
James Kirkland discusses how work by Norman Sharpless and colleagues, published in 2004, paved the way for the development of senolytics, which are now in early phase clinical trials for the treatment of multiple disorders.
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All the sites we cannot see: Sources and mitigation of false negatives in RNA modification studies Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-10-21 Shalini Oberdoeffer, Wendy V. Gilbert
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Molecular mechanisms of mitochondrial dynamics Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-10-17 Luis-Carlos Tábara, Mayuko Segawa, Julien Prudent
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Goodbye, senescent cells: CAR-T cells unleashed to fight ageing Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-10-16 Raffaella Di Micco
Raffaella Di Micco discusses the importance of a 2020 study in which CAR-T cells were engineered to eliminate senescent cells.
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IL-11 as a master regulator of ageing Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-10-16 Ana O’Loghlen
Ana O’Loghlen highlights a recent study that indicates that inhibiting the pro-inflammatory cytokine IL-11 has anti-ageing effects, and how such findings could have implications for the treatment of ageing-associated diseases.
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Molecular tools for analysing in vivo senescence Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-10-14 Allison B. Herman, Myriam Gorospe
Enrichment of senescent cells from organs holds great promise for studying cell senescence and ageing, and for identifying therapeutic vulnerabilities.
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Mechanism and regulation of kinesin motors Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-10-11 Ahmet Yildiz
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The discovery of oncogene-induced senescence Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-10-09 Akiko Takahashi
Akiko Takahashi discusses the seminal 1997 paper by Serrano et al. who found that oncogene activation results in a similar phenotype to replicative senescence, establishing the connection between senescence and cancer.
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Sorting membrane proteins by size in the Golgi Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-10-04 Pauline Kasper, Lisa Heinke
De Caestecker and Macara find that the sorting of membrane proteins in the Golgi relies on a size filter that enables correct localization of proteins with a short cytosolic domain to the apical membrane.
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Following the electric current Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-10-04 Elias H. Barriga
Elias Barriga discusses a seminal 2006 paper from Zhao et al., which was the first study to integrate electrotaxis signals into the established molecular framework enabling directed cell migration.
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Roles of chromatin and genome instability in cellular senescence and their relevance to ageing and related diseases Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-10-03 Zeming Wu, Jing Qu, Guang-Hui Liu
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Mechanisms and regulation of substrate degradation by the 26S proteasome Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-10-03 Connor Arkinson, Ken C. Dong, Christine L. Gee, Andreas Martin
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Rise and SINE: roles of transcription factors and retrotransposons in zygotic genome activation Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-10-02 Pavel Kravchenko, Kikuë Tachibana
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Proteoforms: a tale of two (initiation) sites Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-10-01 Eytan Zlotorynski
mRNAs with alternative in-frame translation initiation sites can yield proteoforms with distinct localization and functions.
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The role and regulation of integrins in cell migration and invasion Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-09-30 Megan R. Chastney, Jasmin Kaivola, Veli-Matti Leppänen, Johanna Ivaska
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Author Correction: The role of the haematopoietic stem cell niche in development and ageing Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-09-26 Terri L. Cain, Marta Derecka, Shannon McKinney-Freeman
Correction to: Nature Reviews Molecular Cell Biology https://doi.org/10.1038/s41580-024-00770-8, published online 10 September 2024.
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Author Correction: Structural biology and molecular pharmacology of voltage-gated ion channels Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-09-24 Jian Huang, Xiaojing Pan, Nieng Yan
Correction to: Nature Reviews Molecular Cell Biology https://doi.org/10.1038/s41580-024-00763-7, published online 5 August 2024.
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Publisher Correction: Generation of nanoscopic membrane curvature for membrane trafficking Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-09-23 Michael M. Kozlov, Justin W. Taraska
Correction to: Nature Reviews Molecular Cell Biology https://doi.org/10.1038/s41580-022-00511-9, published online 22 August 2022.
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The role of the haematopoietic stem cell niche in development and ageing Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-09-10 Terri L. Cain, Marta Derecka, Shannon McKinney-Freeman
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Mechanisms of mechanotransduction and physiological roles of PIEZO channels Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-09-09 Bailong Xiao
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Dynamics of DNA replication speeds in single cells Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-09-05 Jeroen van den Berg
In this Tools of the Trade article, Jeroen van den Berg (van Oudenaarden lab) presents a new method based on pulse-labelling of nascent DNA to study the dynamics of DNA replication in single cells.
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CLASPing and squeezing during cell migration Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-09-04 Lisa Heinke
This study finds that microtubules act as a mechanostat during cell migration, becoming mechanically reinforced in response to compression to protect the nucleus and coordinate contractility.
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Mechanisms of assembly and remodelling of the extracellular matrix Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-09-02 Alexandra Naba
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Epigenetic gene regulation in plants and its potential applications in crop improvement Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-08-27 Heng Zhang, Jian-Kang Zhu
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Profiling cell identity and tissue architecture with single-cell and spatial transcriptomics Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-08-21 Gunsagar S. Gulati, Jeremy Philip D’Silva, Yunhe Liu, Linghua Wang, Aaron M. Newman
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Far from the cytoplasmic crowd Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-08-19 Eytan Zlotorynski
Stresses induce de-crowding and fluidization of the cytoplasm, which promotes the formation of biomolecular condensates.
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Mechanisms of autophagy–lysosome dysfunction in neurodegenerative diseases Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-08-06 Ralph A. Nixon, David C. Rubinsztein
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Structural biology and molecular pharmacology of voltage-gated ion channels Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-08-05 Jian Huang, Xiaojing Pan, Nieng Yan
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MYB-related proteins make chloroplasts Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-08-02 Kim Baumann
MYB-related transcription factors are found to function in chloroplast biogenesis alongside GLK in the distantly related species Marchantia polymorpha and Arabidopsis thaliana.
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What does it take to build a nucleus? Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-07-24 Abigail Buchwalter
Abigail Buchwalter recounts what happened to the nuclei of cells lacking all lamin genes.
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Regulation of and challenges in targeting NAD+ metabolism Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-07-18 Marie E. Migaud, Mathias Ziegler, Joseph A. Baur
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Cellular and pathological functions of tau Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-07-16 Celeste Parra Bravo, Sarah A. Naguib, Li Gan
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The discovery of cyclin-dependent kinases Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-07-15 Paul Nurse
Paul Nurse discusses how a 1971 paper by Culotti and Hartwell inspired him to investigate the cell cycle in fission yeast, and how these genetics studies led to the discovery of cyclin-dependent kinases.
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Virus–host warfare by PROTACs Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-07-09 Kylie J. Walters
The studies that paved the way for the development of PROTACs (proteolysis-targeting chimeras) as therapeutic strategies, and the HPV vaccine.
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Long-lived proteomes in healthy ovaries Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-07-05 Eytan Zlotorynski
Many proteins in the mouse ovary are extremely stable; they enhance proteostasis and limit protein aggregation, thereby supporting the maintenance of the long-lived oocytes.
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Heterochromatin as a balancing act between transcription and gene silencing Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-07-03 Sigurd Braun
An elegant study revealed the distinct roles of different H3K9 methylation states in heterochromatin formation and function.
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Polarized endoplasmic reticulum–plasma membrane contacts in cell migration Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-07-01 Lisa Heinke
In a recent study, Bong et al. identify a polarized distribution of contact sites between the endoplasmic reticulum and plasma membrane in migrating cells, whereby higher density of contacts in the back of the cells prevents the formation of additional migration fronts.
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Pitfalls in lipid mass spectrometry of mammalian samples — a brief guide for biologists Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-07-01 Tore Skotland, Kim Ekroos, Jeffrey McDonald, Robert Ahrends, Gerhard Liebisch, Kirsten Sandvig
This Comment discusses erroneous reporting of mass spectrometry analyses of lipids in mammalian samples, and provides recommendations for how to avoid it. Publications that report mass spectrometry analyses of lipids often include lipid species that probably do not exist in the samples. Here we provide recommendations for scientists on submitting lipid data, and for reviewers, editors and readers on
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Resolution in super-resolution microscopy — definition, trade-offs and perspectives Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-07-01 Kirti Prakash, David Baddeley, Christian Eggeling, Reto Fiolka, Rainer Heintzmann, Suliana Manley, Aleksandra Radenovic, Carlas Smith, Hari Shroff, Lothar Schermelleh
Super-resolution microscopy (SRM) is gaining popularity in biosciences; however, claims about optical resolution are contested and often misleading. In this Viewpoint, experts share their views on resolution and common trade-offs, such as labelling and post-processing, aiming to clarify them for biologists and facilitate deeper understanding and best use of SRM. In this Viewpoint, experts discuss resolution
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Author Correction: Mechanisms controlling cellular and systemic iron homeostasis Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-06-26 Bruno Galy, Marcus Conrad, Martina Muckenthaler
Correction to: Nature Reviews Molecular Cell Biology https://doi.org/10.1038/s41580-023-00648-1, published online 2 October 2023
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Harnessing the deep learning power of foundation models in single-cell omics Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-06-26 Qin Ma, Yi Jiang, Hao Cheng, Dong Xu
Foundation models hold great promise for analyzing single-cell omics data, yet various challenges remain that require further advancements. In this Comment, we discuss the progress, limitations and best practices in applying foundation models to interrogate data and improve downstream tasks in single-cell omics. This Comment discusses the progress, limitations and best practices in applying foundation
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Identification of RNA structures and their roles in RNA functions Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-06-26 Xinang Cao, Yueying Zhang, Yiliang Ding, Yue Wan
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Regulation of cellular and systemic sphingolipid homeostasis Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-06-18 Andrew Kuo, Timothy Hla
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Author Correction: Fundamentals of redox regulation in biology Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-06-17 Helmut Sies, Ryan J. Mailloux, Ursula Jakob
Correction to: Nature Reviews Molecular Cell Biology https://doi.org/10.1038/s41580-024-00730-2 Published online 30 April 2024
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Assembly and fission of tubular carriers mediating protein sorting in endosomes Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-06-17 Navin Gopaldass, Kai-En Chen, Brett Collins, Andreas Mayer
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Monitoring subcellular protein localization at scale in live cells Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-06-10 Jiří Reiniš, Andreas Reicher
In this Tools of the Trade article, Reiniš and Reicher (Kubicek Lab) describe the development of a multicolour protein-tagging strategy that allows live-cell monitoring of multiple proteins.
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The phosphoinositide PI5P inhibits the Hippo pathway effector YAP Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-06-10 Kim Baumann
This study uncovered a link between PI5P, PI5P4Ks and the Hippo pathway, whereby PI5P reinforces the inhibition of YAP, the effector of the Hippo pathway.
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A histone code controls positional identity in limb regeneration Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-06-10 Lisa Heinke
Kawaguchi et al. identify a chromatin code based on repressive histone 3 lysine 27 trimethylation (H3K27me3) that serves as a segment-specific positional marker in connective tissue cells of axolotls, enabling correct patterning during limb regeneration.
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SenNet recommendations for detecting senescent cells in different tissues Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-06-03 Vidyani Suryadevara, Adam D. Hudgins, Adarsh Rajesh, Alberto Pappalardo, Alla Karpova, Amit K. Dey, Ann Hertzel, Anthony Agudelo, Azucena Rocha, Bikem Soygur, Birgit Schilling, Chase M. Carver, Cristina Aguayo-Mazzucato, Darren J. Baker, David A. Bernlohr, Diana Jurk, Dilyana B. Mangarova, Ellen M. Quardokus, Elizabeth Ann L. Enninga, Elizabeth L. Schmidt, Feng Chen, Francesca E. Duncan, Francesco
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Splicing regulation through biomolecular condensates and membraneless organelles Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-05-21 Jimena Giudice, Hao Jiang
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Solving the Wnt nuclear puzzle Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-05-17 Esther M. Verheyen, Cara J. Gottardi
Verheyen and Gottardi revisit two seminal papers by the Basler, Peifer and Clevers labs elucidating the role of nuclear β-catenin in Wnt signal transduction through its interaction with TCF at Wnt target genes.
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Author Correction: Fibroblast and myofibroblast activation in normal tissue repair and fibrosis Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-05-13 Fereshteh Sadat Younesi, Andrew E. Miller, Thomas H. Barker, Fabio M. V. Rossi, Boris Hinz
Correction to: Nature Reviews Molecular Cell Biology https://doi.org/10.1038/s41580-024-00716-0, published online 8 April 2024
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Author Correction: CRISPR technologies for genome, epigenome and transcriptome editing Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-05-13 Lukas Villiger, Julia Joung, Luke Koblan, Jonathan Weissman, Omar O. Abudayyeh, Jonathan S. Gootenberg
Correction to: Nature Reviews Molecular Cell Biology https://doi.org/10.1038/s41580-023-00697-6, published online 2 February 2024
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Integrator and U1 snRNPs steer Pol II in the right direction Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-05-10 Eytan Zlotorynski
Cleavage of promoter-upstream antisense RNAs by the Integrator complex supports the preferential transcription of pre-mRNAs.
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Is amyloid-β a friend or foe? Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-05-02 Claire S. Durrant
Claire Durrant reminds us of the importance of studying the physiological roles of proteins and their aggregates to understand their roles in disease and inform therapies, discussing a 2008 paper on amyloid-β from the Arancio lab.