Bud Craig, an outstanding neuroscientist, died on 15 July 2023 at age 71. Bud made unique contributions to the fields of pain and interoception, challenging major dogmas and offering powerful explanations for various phenomena including central pain and the subjective awareness of feelings, with great implications for our understanding of consciousness.

As Nature Neuroscience celebrates its 25th anniversary, we are having conversations with both established leaders in the field and those earlier in their careers to discuss how neuroscience has evolved and where it is heading. This month, we are talking to Theanne Griffith, Assistant Professor in the Department of Physiology and Membrane Biology at the University of California, Davis. We spoke about

As Nature Neuroscience celebrates its 25th anniversary, we are having conversations with both established leaders in the field and those earlier in their careers to discuss how the field has evolved and where it is heading. This month we are talking to Freda Miller, Deputy Director and Professor of Developmental Neurobiology at University of British Columbia. She is known for her work on neuronal and

Bayless, Davis, Yang et al. have mapped the circuit for mating behavior in male mice. They show that neurons that express substance P (also known as tachykinin 1) in the principal nucleus of the bed nucleus of the stria terminalis (BNSTprTac1 neurons) are sufficient to signal the presence of a female mouse. These cells synapse onto tachykinin receptor 1-expressing neurons in the preoptic area (POATacr1

Tauopathies are a group of neurodegenerative diseases characterized by the presence of intracellular neurofibrillary tangles of hyperphosphorylated microtubule-associated protein tau. How soluble monomeric tau is converted into insoluble fibrillar aggregates is not fully understood. In a recent paper published in Science, Zhang et al. analysed more than 70 human tripartite motif (TRIM) proteins that

Microglia can exist in various states depending on their environment and pathological conditions. Understanding the roles of these states and their contributions to disease is a major goal of neuroimmunology research. However, modelling native microglial states in vitro is challenging, as a lack of brain-derived cues cause microglia to rapidly change their gene expression profiles. In a recent Nature

As Nature Neuroscience celebrates its 25th anniversary, we are having conversations with both established leaders in the field and those earlier in their careers to discuss how neuroscience has evolved, and where it is heading. This month, we are talking to Marguerite Matthews, Program Director at the Office of Programs to Enhance Neuroscience Workforce Diversity at the National Institute of Neurological

As Nature Neuroscience celebrates its 25th anniversary, we are having conversations with both established leaders in the field and those earlier in their careers to discuss how the field has evolved and where it is heading. This month we are talking to Richard Tsien, the Druckenmiller Professor of Neuroscience in the Department of Neuroscience and Physiology at New York University Langone Medical Center

Efforts to design anti-amyloid therapies for Alzheimer’s disease have been unsuccessful until very recently. Donanemab has joined aducunamab and lecanemab as the third anti-amyloid-β (Aβ) drug to show significant beneficial effects, as indicated by results from the TRAILBLAZER-ALZ2 randomized phase III clinical trial, published in Journal of the American Medical Association. Donanemab is a monoclonal

Chronic pain conditions are influenced by biological, psychological and social factors. Tanguay-Sabourin et al. found that in data from the UK Biobank, people with acute or chronic pain reported pain at multiple body sites, more often between proximal sites than between distal sites, and that the number of pain sites increased with pain duration. The authors therefore trained machine learning algorithms

In the external globus pallidus (GPe), a subpopulation of neurons that send projections back to the dorsal striatum is known as arkypallidal (or ‘arky’) neurons. In a study published in Nature Communications, Baker, Kang et al. investigated whether arkypallidal neurons are involved during operant reward-seeking behaviors in mice. Fiber photometric measurements of GPe neurons that project to the dorsolateral

As Nature Neuroscience celebrates its 25th anniversary, we are having conversations with both established leaders in the field and those earlier in their careers to discuss how neuroscience has evolved, and where it is heading. This month, we are talking to Andrew Huberman, Associate Professor of Neurobiology at Stanford University and host of the very popular Huberman Lab podcast. We spoke about his

As Nature Neuroscience celebrates its 25th anniversary, we are having conversations with both established leaders in the field and those earlier in their careers to discuss how neuroscience has evolved and where it is heading. This month, we are talking to Mario Penzo, Chief of the Section on the Neural Circuits of Emotion and Motivation at the US National Institute of Mental Health (NIMH). We spoke

Rodent studies suggest that post-ingestive nutrient signals to the brain alter dopamine release in the striatum independently of the orosensory response. This has potential implications for regulating eating behavior and obesity, but there are fewer studies in humans. A recent paper in Nature Metabolism by van Galen et al. studied changes in neural activity and dopamine release in lean individuals