Go to
current issue
-
Phosphodiesterases in heart and vessels- From Physiology to Diseases Physiol. Rev. (IF 33.6) Pub Date : 2023-11-16 Qin Fu, Ying Wang, Chen Yan, Yang K. Xiang
Physiological Reviews, Ahead of Print.
-
Editorial on Davis et al. Physiol. Rev. (IF 33.6) Pub Date : 2023-11-09 Brooke R. Shepley, Anthony R. Bain
Physiological Reviews, Ahead of Print.
-
Cannabinoid treatments in epilepsy and seizure disorders Physiol. Rev. (IF 33.6) Pub Date : 2023-10-26 Orrin Devinsky, Nicholas A. Jones, Mark O. Cunningham, B. Ashan P. Jayaskera, Sasha Devore, Benjamin J. Whalley
Physiological Reviews, Ahead of Print.
-
CD36 as a gatekeeper of myocardial lipid metabolism and therapeutic target for metabolic disease Physiol. Rev. (IF 33.6) Pub Date : 2023-10-26 Jan F.C. Glatz, Lisa C. Heather, Joost J.F.P. Luiken
Physiological Reviews, Ahead of Print.
-
Netosis creates a link between diabetes and Long COVID Physiol. Rev. (IF 33.6) Pub Date : 2023-10-19 Alain R. THIERRY
Physiological Reviews, Ahead of Print.
-
Oxidative damage in neurodegeneration: roles in the pathogenesis and progression of Alzheimer disease Physiol. Rev. (IF 33.6) Pub Date : 2023-10-16 Marzia Perluigi, Fabio Di Domenico, D. Allan Butterfield
Physiological Reviews, Volume 104, Issue 1, Page 103-197, January 2024.
-
Multiscale Structure and Function of the Aortic Valve Apparatus Physiol. Rev. (IF 33.6) Pub Date : 2023-09-21 Hussam El-Nashar, Malak Sabry, Yuan-Tsan Tseng, Nadine Francis, Najma Latif, Kim H. Parker, James E. Moore, Magdi H. Yacoub
Physiological Reviews, Ahead of Print.
-
Glucocorticoids, Their Uses, Sexual Dimorphisms, and Diseases: New Concepts, Mechanisms, and Discoveries Physiol. Rev. (IF 33.6) Pub Date : 2023-09-21 Genesee J Martinez, Malik Appleton, Zachary A. Kipp, Analia S. Loria, Booki Min, Terry D Hinds
Physiological Reviews, Ahead of Print.
-
Tissue Transglutaminase: A Multifunctional and Multisite Regulator in Health and Disease Physiol. Rev. (IF 33.6) Pub Date : 2023-09-15 Zhouzhou Yao, Yuhua Fan, Lizhen Lin, Rodney E. Kellems, Yang Xia
Physiological Reviews, Ahead of Print.
-
SIRT7: the seventh key to unlocking the mystery of aging Physiol. Rev. (IF 33.6) Pub Date : 2023-09-07 Umar Raza, Xiaolong Tang, Zuojun Liu, Baohua Liu
Physiological Reviews, Ahead of Print.
-
New insights into the physiology and pathophysiology of the atypical sodium leak channel NALCN Physiol. Rev. (IF 33.6) Pub Date : 2023-08-24 Arnaud Monteil, Adriano Senatore, Antonio Gil-Nagel, Paloma Parra-Diaz, Philippe Lory, Nathalie C. Guérineau
Physiological Reviews, Ahead of Print.
-
Community-Acquired Bacterial Co-infections and COVID-19 Physiol. Rev. (IF 33.6) Pub Date : 2023-08-17 Michael John Patton, Amit Gaggar, Matthew Might, Nathaniel Erdmann, Carlos J. Orihuela, Kevin S. Harrod
Physiological Reviews, Ahead of Print.
-
Mesenchymal stromal cells for improvement of cardiac function following acute myocardial infarction: a matter of timing Physiol. Rev. (IF 33.6) Pub Date : 2023-08-17 Stéphanie Barrère-Lemaire, Anne Vincent, Christian Jorgensen, Christophe Piot, Joël Nargeot, Farida Djouad
Physiological Reviews, Ahead of Print.
-
The Role of Quality Metrics in the Evolution of AI in Healthcare and Implications for Generative AI Physiol. Rev. (IF 33.6) Pub Date : 2023-08-10 Ryan C. Godwin, Ryan L. Melvin
Physiological Reviews, Ahead of Print.
-
Recent Insights into Channelopathies Physiol. Rev. (IF 33.6) Pub Date : 2023-08-10 Osama F. Harraz, Eric Delpire
Physiological Reviews, Ahead of Print.
-
Ca2+ dynamics in interstitial cells: foundational mechanisms for the motor patterns in the gastrointestinal tract Physiol. Rev. (IF 33.6) Pub Date : 2023-08-10 Kenton M. Sanders, Bernard T. Drumm, Caroline A. Cobine, Salah A. Baker
Physiological Reviews, Ahead of Print.
-
Lung Endothelium, Tau, and Amyloids in Health and Disease Physiol. Rev. (IF 33.6) Pub Date : 2023-08-10 Ron Balczon, Mike T. Lin, Sarah Voth, Amy R. Nelson, Jonas C. Schupp, Brant M. Wagener, Jean-Francois Pittet, Troy Stevens
Physiological Reviews, Ahead of Print.
-
Sex Differences in Blood Pressure Regulation and Hypertension: Renal, Hemodynamic, and Hormonal Mechanisms Physiol. Rev. (IF 33.6) Pub Date : 2023-07-21 Erika R. Drury, Jing Wu, Joseph C. Gigliotti, Thu H. Le
Physiological Reviews, Ahead of Print.
-
Obstructive nephropathy and molecular pathophysiology of renal interstitial fibrosis Physiol. Rev. (IF 33.6) Pub Date : 2023-07-13 Rikke Nørregaard, Henricus A.M. Mutsaers, Jorgen Frøkiær, Tae-Hwan Kwon
Physiological Reviews, Ahead of Print.
-
Sympathetic circuits regulating hepatic glucose metabolism, where we stand Physiol. Rev. (IF 33.6) Pub Date : 2023-07-13 Andrea Zsombok, Lucie D Desmoulins, Andrei V Derbenev
Physiological Reviews, Ahead of Print.
-
The Conducted Vasomotor Response and the Principles of Electrical Communication in Resistance Arteries Physiol. Rev. (IF 33.6) Pub Date : 2023-07-06 Galina Yu. Mironova, Paulina M. Kowalewska, Mohammed El-Lakany, Cam Ha T. Tran, Maria Sancho, Anil Zechariah, William F. Jackson, Donald G. Welsh
Physiological Reviews, Ahead of Print.
-
Mechanisms of mechanical overload-induced skeletal muscle hypertrophy: current understanding and future directions Physiol. Rev. (IF 33.6) Pub Date : 2023-06-29 Michael D. Roberts, John J. McCarthy, Troy A. Hornberger, Stuart M. Phillips, Abigail L. Mackey, Gustavo A. Nader, Marni D. Boppart, Andreas N. Kavazis, Paul T. Reidy, Riki Ogasawara, Cleiton A. Libardi, Carlos Ugrinowitsch, Frank W. Booth, Karyn A. Esser
Physiological Reviews, Ahead of Print.
-
Mechanisms of SARS-CoV-2 Associated Anosmia Physiol. Rev. (IF 33.6) Pub Date : 2023-06-21 Tatsuya Tsukahara, David H. Brann, Sandeep Robert Datta
Physiological Reviews, Ahead of Print.
-
Climate Change Impacts on Respiratory Health: Exposure, Vulnerability, and Risk Physiol. Rev. (IF 33.6) Pub Date : 2023-06-16 Hannah H. Covert, Firoz Abdoel Wahid, Sally E. Wenzel, Maureen Y. Lichtveld
Physiological Reviews, Ahead of Print.
-
Physiology of intracellular calcium buffering Physiol. Rev. (IF 33.6) Pub Date : 2023-06-16 David Eisner, Erwin Neher, Holger Taschenberger, Godfrey Smith
Physiological Reviews, Ahead of Print.
-
The Physiology of Sedentary Behavior Physiol. Rev. (IF 33.6) Pub Date : 2023-06-16 Ana J. Pinto, Audrey Bergouignan, Paddy C. Dempsey, Hamilton Roschel, Neville Owen, Bruno Gualano, David W. Dunstan
Physiological Reviews, Ahead of Print.
-
Synaptic memory and CaMKII: a review Physiol. Rev. (IF 33.6) Pub Date : 2023-06-08 Roger A. Nicoll, Howard Schulman
Physiological Reviews, Ahead of Print.
-
Making a good egg: human oocyte health, aging and in vitro development Physiol. Rev. (IF 33.6) Pub Date : 2023-05-12 Evelyn Elizabeth Telfer, Johanne Grosbois, Yvonne L. Odey, Roseanne Rosario, Richard A. Anderson
Physiological Reviews, Ahead of Print.
-
The placenta: Epigenetic insights into trophoblast developmental models of a generation-bridging organ with long-lasting impact on lifelong health Physiol. Rev. (IF 33.6) Pub Date : 2023-05-12 Myriam Hemberger, Wendy Dean
Physiological Reviews, Ahead of Print.
-
Leveraging Physiology and Artificial Intelligence to Deliver Advancements in Healthcare Physiol. Rev. (IF 33.6) Pub Date : 2023-04-27 Angela Zhang, Zhenquin Wu, Eric Wu, Matthew Wu, Michael P. Snyder, James Zou, Joseph C. Wu
Physiological Reviews, Ahead of Print.
-
Mitochondria in Health, Disease, and Ageing Physiol. Rev. (IF 33.6) Pub Date : 2023-04-06 John S. Harrington, Stefan W. Ryter, Maria Plataki, David R. Price, Augustine M.K. Choi
Physiological Reviews, Ahead of Print.
-
Bioenergetics: The Evolutionary Basis of Progressive Kidney Disease Physiol. Rev. (IF 33.6) Pub Date : 2023-03-30 Robert L. Chevalier
Physiological Reviews, Ahead of Print.
-
The human periconceptional maternal-embryonic space in health and disease Physiol. Rev. (IF 33.6) Pub Date : 2023-02-16 Inmaculada Moreno, Antonio Capalbo, Aymara Mas, Tamara Garrido-Gomez, Beatriz Roson, Maurizio Poli, Eva Dimitriadis, Xavier Santamaria, Felipe Vilella, Carlos Simon
Physiological Reviews, Ahead of Print.
-
Membrane Adhesion Junctions Regulate Airway Smooth Muscle Function and Phenotype Physiol. Rev. (IF 33.6) Pub Date : 2023-02-16 Wenwu Zhang, Yidi Wu, Susan Gunst
Physiological Reviews, Ahead of Print.
-
The long-term variability of human health related solar ultraviolet-B radiation doses for the 1980s to the end of 21st century Physiol. Rev. (IF 33.6) Pub Date : 2023-02-14 Christos Zerefos, Ilias Fountoulakis, Kostas Eleftheratos, Andreas Kazantzidis
Physiological Reviews, Ahead of Print.
-
The multiple roles of salt-inducible kinases in regulating physiology Physiol. Rev. (IF 33.6) Pub Date : 2023-02-02 Aarti Jagannath, Lewis Taylor, Yining Ru, Zeinab Wakaf, Kayomavua Akpobaro, Sridhar Vasudevan, Russell G. Foster
Physiological Reviews, Ahead of Print.
-
The intercalated disc: a unique organelle for electromechanical synchrony in cardiomyocytes Physiol. Rev. (IF 33.6) Pub Date : 2023-02-02 Morten S. Nielsen, Chantal J.M. van Opbergen, Toon A.B. van Veen, Mario Delmar
Physiological Reviews, Ahead of Print.
-
Mesenchymal Condensation in Tooth Development and Regeneration: a Focus on Translational Aspects of Organogenesis Physiol. Rev. (IF 33.6) Pub Date : 2023-01-19 Bing-Dong Sui, Chen-Xi Zheng, Wan-Min Zhao, Kun Xuan, Bei Li, Yan Jin
The teeth are vertebrate-specific and highly specialized organs performing fundamental functions of mastication and speech, the maintenance of which is crucial for orofacial homeostasis and is further linked to systemic health and human psychosocial well-being. However, with limited ability of self-repair, the teeth can often be impaired by traumatic, inflammatory and progressive insults, leading to
-
Genome-wide association studies of cardiovascular disease Physiol. Rev. (IF 33.6) Pub Date : 2023-01-12 Roddy Walsh, Sean J. Jurgens, Jeanette Erdmann, Connie R. Bezzina
Genome-wide association studies (GWAS) aim to identify common genetic variants that are associated with traits and diseases. Since 2005, more than 5,000 GWAS have been published for almost as many traits. These studies have offered insights into the loci and genes underlying phenotypic traits, highlighted genetic correlations across traits and diseases and are beginning to demonstrate clinical utility
-
Examining the shared etiology of psychopathology with genome-wide association studies Physiol. Rev. (IF 33.6) Pub Date : 2023-01-12 Travis T. Mallard, Andrew D. Grotzinger, Jordan W. Smoller
Genome-wide association studies (GWASs) have ushered in a new era of reproducible discovery in psychiatric genetics. The field has now identified hundreds of common genetic variants that are associated with mental disorders - many of which influence more than one disorder. By advancing understanding of causal biology underlying psychopathology, GWAS results are poised to inform the development of novel
-
Vascular Mechanotransduction Physiol. Rev. (IF 33.6) Pub Date : 2023-01-05 Michael J. Davis, Scott Earley, Yi-Shuan Li, Shu Chien
This review aims to survey the current state of mechanotransduction in vascular smooth muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical stimuli and transduction of mechanical signals that result in the acute functional modulation and longer-term transcriptomic and epigenetic regulation of blood vessels. The mechanosensors discussed include ion channels, plasma
-
Comparative Physiological Anthropogeny: Exploring Molecular Underpinnings of Distinctly Human Phenotypes Physiol. Rev. (IF 33.6) Pub Date : 2023-01-05 Michael Vaill, Kunio Kawanishi, Nissi Varki, Pascal Gagneux, Ajit Varki
Anthropogeny is a classic term encompassing transdisciplinary investigations of the origins of the human species. Comparative Anthropogeny is a systematic comparison of humans and other living non-human hominids (so-called "Great Apes"), aiming to identify distinctly human features in health and disease, with the overall goal of explaining human origins. We begin with a historical perspective, briefly
-
The molecular athlete: exercise physiology from mechanisms to medals Physiol. Rev. (IF 33.6) Pub Date : 2023-01-05 Regula Furrer, John A. Hawley, Christoph Handschin
Physiological Reviews, Ahead of Print.
-
The enteric nervous system Physiol. Rev. (IF 33.6) Pub Date : 2022-12-15 Keith A. Sharkey, Gary M. Mawe
Of all the organ systems in the body, the gastrointestinal tract is the most complicated in terms of numbers of the structures involved, each with different functions, and the numbers and types of signaling molecules utilized. The digestion of food and absorption of nutrients, electrolytes and waters occurs in a hostile luminal environment that contains a large and diverse microbiota. At the core of
-
CGRP physiology, pharmacology, and therapeutic targets: Migraine and beyond Physiol. Rev. (IF 33.6) Pub Date : 2022-12-01 Andrew F. Russo, Debbie L. Hay
Calcitonin gene-related peptide (CGRP) is a neuropeptide with diverse physiological functions. Its two isoforms (α and β) are widely expressed throughout the body in sensory neurons, as well as in other cell types, such as motor neurons and neuroendocrine cells. CGRP acts via at least two G protein-coupled receptors that form unusual complexes with receptor activity-modifying proteins. These are the
-
Pathophysiology and Pathogenic Mechanisms of Pulmonary Hypertension: Role of Membrane Receptors, Ion Channels and Ca2+ Signaling Physiol. Rev. (IF 33.6) Pub Date : 2022-11-24 Angela Balistrieri, Ayako Makino, Jason X.-J. Yuan
Abstract The pulmonary circulation is a low-resistance, low-pressure and high-compliance system that allows the lungs to receive entire cardiac output. Pulmonary arterial pressure is a function of cardiac output and pulmonary vascular resistance, while pulmonary vascular resistance is inversely proportional to the fourth power of the intraluminal radius of the pulmonary artery. Therefore, a very small
-
The Elusive Cephalic Phase Insulin Response: Triggers, Mechanisms, and Functions Physiol. Rev. (IF 33.6) Pub Date : 2022-11-24 Wolfgang Langhans, Alan G. Watts, Alan C. Spector
Physiological Reviews, Ahead of Print.
-
Physiology of the tongue with emphasis on taste transduction Physiol. Rev. (IF 33.6) Pub Date : 2022-11-24 Máire E. Doyle, Hasitha U. Premathilake, Qin Yao, Caio H. Mazucanti, Josephine M. Egan
The tongue is a complex multifunctional organ that interacts and senses both interoceptively and exteroceptively. Although it is easily visible to almost all of us it is relatively understudied and what is in the literature as regards taste mechanisms is often contradictory or is not comprehensively reported. The tongue is both a motor and a sensory organ: motor in that it is required for speech and
-
Windows into stress: A glimpse at emerging roles for CRHPVN neurons Physiol. Rev. (IF 33.6) Pub Date : 2022-11-17 Neilen P. Rasiah, Spencer P. Loewen, Jaideep S. Bains
The corticotropin releasing hormone cells in the paraventricular nucleus of the hypothalamus (CRHPVN) control the slow endocrine response to stress. The synapses on these cells are exquisitely sensitive to acute stress, leveraging local signals to leave a lasting imprint on this system. Additionally, recent work indicates these cells also play key roles in the control of distinct stress and survival
-
Molecular Responses to Acute Exercise and Their Relevance for Adaptations in Skeletal Muscle to Exercise Training Physiol. Rev. (IF 33.6) Pub Date : 2022-11-17 Brendan Egan, Adam P. Sharples
Repeated, episodic bouts of skeletal muscle contraction undertaken frequently as structured exercise training is a potent stimulus for physiological adaptation in many organs. Specifically in skeletal muscle, remarkable plasticity is demonstrated by the remodeling of muscle structure and function in terms of muscular size, force, endurance, and contractile velocity as a result of the functional demands
-
Chloride transporters controlling neuronal excitability Physiol. Rev. (IF 33.6) Pub Date : 2022-10-27 Jessica C. Pressey, Miranda de Saint-Rome, Vineeth A. Raveendran, Melanie A. Woodin
Synaptic inhibition plays a crucial role in regulating neuronal excitability, which is the foundation of nervous system function. This inhibition is largely mediated by the neurotransmitters GABA and glycine that activate Cl--permeable ion channels, which means that the strength of inhibition depends on the Cl- gradient across the membrane. In neurons, the Cl- gradient is primarily determined by two
-
A Multisystem Physiological Perspective of Human Frailty and Its Modulation by Physical Activity Physiol. Rev. (IF 33.6) Pub Date : 2022-10-14 Joseph A. Taylor, Paul L. Greenhaff, David B. Bartlett, Thomas A. Jackson, Niharika A. Duggal, Janet M. Lord
"Frailty" is a term used to refer to a state characterised by enhanced vulnerability to, and impaired recovery from, stressors, when compared to a non-frail state, which is increasingly viewed as a loss of resilience. With increasing life expectancy and the associated rise in years spent with physical frailty, there is a need to understand the clinical and physiological features of frailty and the
-
Corrigendum for Davis et al., volume 101, 2020, p. 319–352 Physiol. Rev. (IF 33.6) Pub Date : 2022-10-14
Physiological Reviews, Volume 103, Issue 1, Page 607-607, January 2023.
-
Contributions of acquired immunity to the development of COPD in humans and animal models Physiol. Rev. (IF 33.6) Pub Date : 2022-10-06 Farrah Kheradmand, Yun Zhang, David B. Corry
The pathophysiology of chronic obstructive pulmonary disease (COPD) and the undisputed role of innate immune cells in this condition has dominated the field in the basic research. Recently, however, compelling data suggesting that adaptive immune cells may also contribute to the progressive nature of lung destruction associated with COPD in smokers has gained considerable attention. The histopathological
-
The choroid plexus: a missing link in our understanding of brain development and function Physiol. Rev. (IF 33.6) Pub Date : 2022-09-29 Norman R. Saunders, Katarzyna M. Dziegielewska, Ryann M. Fame, Maria K. Lehtinen, Shane A. Liddelow
Studies of the choroid plexuses lag behind those of, the more widely known, blood brain barrier in spite of a much longer history. This review has two overall aims. The first is to outline longstanding areas of research where there are unanswered questions, such as control of cerebrospinal fluid (CSF) secretion and blood flow. The second part reviews research over the past ten years where the focus
-
A Systematic Review of the Biological Mediators of Fat-Taste and Smell Physiol. Rev. (IF 33.6) Pub Date : 2022-09-15 Rosario B. Jaime-Lara, Brianna E. Brooks, Carlotta Vizioli, Mari Chiles, Nafisa Nawal, Rodrigo S.E. Ortiz-Figueroa, Alicia A. Livinski, Khushbu Agarwal, Claudia Colina-Prisco, Natalia Iannarino, Aliya Hilmi, Hugo A. Tejeda, Paule V. Joseph
Taste and smell play a key role in our ability to perceive foods. Overconsumption of highly palatable energy-dense foods can lead to increased caloric intake and obesity. Thus, there is growing interest in the study of the biological mediators of fat taste and associated olfaction as potential targets for pharmacologic and nutritional interventions in the context of obesity and health. The number of
-
Systematic Reviews for Basic Scientists: A Different Beast Physiol. Rev. (IF 33.6) Pub Date : 2022-09-01 John P.A. Ioannidis
Physiological Reviews, Ahead of Print.
-
Adaptation in auditory processing Physiol. Rev. (IF 33.6) Pub Date : 2022-09-01 Benjamin D. B. Willmore, Andrew J. King
Adaptation is an essential feature of auditory neurons, which reduces their responses to unchanging and recurring sounds and allows their response properties to be matched to the constantly changing statistics of sounds that reach the ears. As a consequence, processing in the auditory system highlights novel or unpredictable sounds and produces an efficient representation of the vast range of sounds
-
Cellular senescence and cardiovascular diseases: moving to the "heart" of the problem Physiol. Rev. (IF 33.6) Pub Date : 2022-09-01 Konstantinos Evangelou, Panagiotis VS Vasileiou, Angelos Papaspyropoulos, Orsalia Hazapis, Russell Petty, Marco Demaria, Vassilis G. Gorgoulis
Cardiovascular diseases (CVDs) constitute the prime cause of global mortality with an immense impact on patient quality of life and disability. Clinical evidence has revealed a strong connection between cellular senescence and worse cardiac outcomes in the majority of CVDs concerning both ischemic and non-ischemic cardiomyopathies. Cellular senescence is characterized by cell cycle arrest accompanied
-
Clonal Hematopoiesis, Somatic Mosaicism, and Age-Associated Disease Physiol. Rev. (IF 33.6) Pub Date : 2022-09-01 Megan A. Evans, Kenneth Walsh
Somatic mosaicism - the occurrence of multiple genetically distinct cell clones within the same tissue - is an evitable consequence of human aging. The hematopoietic system is no exception to this, where studies have revealed the presence of expanded blood cell clones carrying mutations in preleukemic driver genes and/or genetic alterations in chromosomes. This phenomenon is referred to as clonal hematopoiesis
Copyright © 2014-2023 北京衮雪科技有限公司 All Rights Reserved
京ICP备11026495-2号
京公网安备 11010802027423号
京公网安备 11010802027423号