The enteric nervous system relays psychological stress to intestinal inflammation
Cell
(IF 66.85)
Pub Date : 2023-05-25
Kai Markus Schneider, Niklas Blank, Yelina Alvarez, Katharina Thum, Patrick Lundgren, Lev Litichevskiy, Madeleine Sleeman, Klaas Bahnsen, Jihee Kim, Simon Kardo, Shaan Patel, Lenka Dohnalová, Giulia T. Uhr, Hélène C. Descamps, Susanna Kircher, Alana M. McSween, Ashkan Rezazadeh Ardabili, Kelsey M. Nemec, Monica T. Jimenez, Lila G. Glotfelty, Christoph A. Thaiss
C5a-licensed phagocytes drive sterilizing immunity during systemic fungal infection
Cell
(IF 66.85)
Pub Date : 2023-05-22
Jigar V. Desai, Dhaneshwar Kumar, Tilo Freiwald, Daniel Chauss, Melissa D. Johnson, Michael S. Abers, Julie M. Steinbrink, John R. Perfect, Barbara Alexander, Vasiliki Matzaraki, Brendan D. Snarr, Marissa A. Zarakas, Vasileios Oikonomou, Lakmali M. Silva, Raju Shivarathri, Emily Beltran, Luciana Negro Demontel, Luopin Wang, Jean K. Lim, Dylan Launder, Michail S. Lionakis
Systematic identification of anticancer drug targets reveals a nucleus-to-mitochondria ROS-sensing pathway
Cell
(IF 66.85)
Pub Date : 2023-05-15
Junbing Zhang, Claire M. Simpson, Jacqueline Berner, Harrison B. Chong, Jiafeng Fang, Zehra Ordulu, Tommy Weiss-Sadan, Anthony P. Possemato, Stefan Harry, Mariko Takahashi, Tzu-yi Yang, Marianne Richter, Himani Patel, Abby E. Smith, Alexander D. Carlin, Adriaan F. Hubertus de Groot, Konstantin Wolf, Lei Shi, Ting-Yu Wei, Benedikt R. Dürr, Liron Bar-Peled
Sites of transcription initiation drive mRNA isoform selection
Cell
(IF 66.85)
Pub Date : 2023-05-12
Carlos Alfonso-Gonzalez, Ivano Legnini, Sarah Holec, Laura Arrigoni, Hasan Can Ozbulut, Fernando Mateos, David Koppstein, Agnieszka Rybak-Wolf, Ulrike Bönisch, Nikolaus Rajewsky, Valérie Hilgers
Ex utero monkey embryogenesis from blastocyst to early organogenesis
Cell
(IF 66.85)
Pub Date : 2023-05-11
Yandong Gong, Bing Bai, Nianqin Sun, Baiquan Ci, Honglian Shao, Ting Zhang, Hui Yao, Youyue Zhang, Yuyu Niu, Lizhong Liu, Hu Zhao, Hao Wu, Lei Zhang, Tianxiang Wang, Shangang Li, Yulei Wei, Yang Yu, Ana Elisa Ribeiro Orsi, Bing Liu, Weizhi Ji, Tao Tan
An in vivo neuroimmune organoid model to study human microglia phenotypes
Cell
(IF 66.85)
Pub Date : 2023-05-11
Simon T. Schafer, Abed AlFatah Mansour, Johannes C.M. Schlachetzki, Monique Pena, Saeed Ghassemzadeh, Lisa Mitchell, Amanda Mar, Daphne Quang, Sarah Stumpf, Irene Santisteban Ortiz, Addison J. Lana, Clara Baek, Raghad Zaghal, Christopher K. Glass, Axel Nimmerjahn, Fred H. Gage
Bat ASC2 suppresses inflammasomes and ameliorates inflammatory diseases
Cell
(IF 66.85)
Pub Date : 2023-05-11
Matae Ahn, Vivian Chih-Wei Chen, Pritisha Rozario, Wei Lun Ng, Pui San Kong, Wan Rong Sia, Adrian Eng Zheng Kang, Qi Su, Lan Huong Nguyen, Feng Zhu, Wharton O.Y. Chan, Chee Wah Tan, Wan Shoo Cheong, Ying Ying Hey, Randy Foo, Fusheng Guo, Yan Ting Lim, Xin Li, Wan Ni Chia, Radoslaw M. Sobota, Lin-Fa Wang
Structure of the endosomal Commander complex linked to Ritscher-Schinzel syndrome
Cell
(IF 66.85)
Pub Date : 2023-05-11
Michael D. Healy, Kerrie E. McNally, Rebeka Butkovič, Molly Chilton, Kohji Kato, Joanna Sacharz, Calum McConville, Edmund R.R. Moody, Shrestha Shaw, Vicente J. Planelles-Herrero, Sathish K.N. Yadav, Jennifer Ross, Ufuk Borucu, Catherine S. Palmer, Kai-En Chen, Tristan I. Croll, Ryan J. Hall, Nikeisha J. Caruana, Rajesh Ghai, Thi H.D. Nguyen, Peter J. Cullen
Plasma membrane preassociation drives β-arrestin coupling to receptors and activation
Cell
(IF 66.85)
Pub Date : 2023-05-04
Jak Grimes, Zsombor Koszegi, Yann Lanoiselée, Tamara Miljus, Shannon L. O’Brien, Tomasz M. Stepniewski, Brian Medel-Lacruz, Mithu Baidya, Maria Makarova, Ravi Mistry, Joëlle Goulding, Julia Drube, Carsten Hoffmann, Dylan M. Owen, Arun K. Shukla, Jana Selent, Stephen J. Hill, Davide Calebiro
Structure-based discovery of conformationally selective inhibitors of the serotonin transporter
Cell
(IF 66.85)
Pub Date : 2023-05-02
Isha Singh, Anubha Seth, Christian B. Billesbølle, Joao Braz, Ramona M. Rodriguiz, Kasturi Roy, Bethlehem Bekele, Veronica Craik, Xi-Ping Huang, Danila Boytsov, Vladimir M. Pogorelov, Parnian Lak, Henry O’Donnell, Walter Sandtner, John J. Irwin, Bryan L. Roth, Allan I. Basbaum, William C. Wetsel, Aashish Manglik, Brian K. Shoichet, Gary Rudnick
Clp-targeting BacPROTACs impair mycobacterial proteostasis and survival
Cell
(IF 66.85)
Pub Date : 2023-05-02
David M. Hoi, Sabryna Junker, Lukas Junk, Kristin Schwechel, Katharina Fischel, David Podlesainski, Paige M.E. Hawkins, Lasse van Geelen, Farnusch Kaschani, Julia Leodolter, Francesca Ester Morreale, Stefan Kleine, Somraj Guha, Klaus Rumpel, Volker M. Schmiedel, Harald Weinstabl, Anton Meinhart, Richard J. Payne, Markus Kaiser, Markus Hartl, Tim Clausen
Molecular mechanisms of stress-induced reactivation in mumps virus condensates
Cell
(IF 66.85)
Pub Date : 2023-04-27
Xiaojie Zhang, Sindhuja Sridharan, Ievgeniia Zagoriy, Christina Eugster Oegema, Cyan Ching, Tim Pflaesterer, Herman K.H. Fung, Isabelle Becher, Ina Poser, Christoph W. Müller, Anthony A. Hyman, Mikhail M. Savitski, Julia Mahamid
A tissue injury sensing and repair pathway distinct from host pathogen defense
Cell
(IF 66.85)
Pub Date : 2023-04-24
Siqi Liu, Yun Ha Hur, Xin Cai, Qian Cong, Yihao Yang, Chiwei Xu, Angelina M. Bilate, Kevin Andrew Uy Gonzales, S. Martina Parigi, Christopher J. Cowley, Brian Hurwitz, Ji-Dung Luo, Tiffany Tseng, Shiri Gur-Cohen, Megan Sribour, Tatiana Omelchenko, John Levorse, Hilda Amalia Pasolli, Craig B. Thompson, Daniel Mucida, Elaine Fuchs
The T-cell-directed vaccine BNT162b4 encoding conserved non-spike antigens protects animals from severe SARS-CoV-2 infection
Cell
(IF 66.85)
Pub Date : 2023-04-13
Christina M. Arieta, Yushu Joy Xie, Daniel A. Rothenberg, Huitian Diao, Dewi Harjanto, Shirisha Meda, Krisann Marquart, Byron Koenitzer, Tracey E. Sciuto, Alexander Lobo, Adam Zuiani, Stefanie A. Krumm, Carla Iris Cadima Couto, Stephanie Hein, André P. Heinen, Thomas Ziegenhals, Yunpeng Liu-Lupo, Annette B. Vogel, John R. Srouji, Stephanie Fesser, Asaf Poran
Dietary tryptophan metabolite released by intratumoral Lactobacillus reuteri facilitates immune checkpoint inhibitor treatment
Cell
(IF 66.85)
Pub Date : 2023-04-06
Mackenzie J. Bender, Alex C. McPherson, Catherine M. Phelps, Surya P. Pandey, Colin R. Laughlin, Jake H. Shapira, Luzmariel Medina Sanchez, Mohit Rana, Tanner G. Richie, Tahliyah S. Mims, Angela M. Gocher-Demske, Luisa Cervantes-Barragan, Steven J. Mullett, Stacy L. Gelhaus, Tullia C. Bruno, Nikki Cannon, John A. McCulloch, Dario A.A. Vignali, Reinhard Hinterleitner, Alok V. Joglekar, Marlies Meisel
T cell immunotherapies engage neutrophils to eliminate tumor antigen escape variants
Cell
(IF 66.85)
Pub Date : 2023-03-30
Daniel Hirschhorn, Sadna Budhu, Lukas Kraehenbuehl, Mathieu Gigoux, David Schröder, Andrew Chow, Jacob M. Ricca, Billel Gasmi, Olivier De Henau, Levi Mark B. Mangarin, Yanyun Li, Linda Hamadene, Anne-Laure Flamar, Hyejin Choi, Czrina A. Cortez, Cailian Liu, Aliya Holland, Sara Schad, Isabell Schulze, Allison Betof Warner, Taha Merghoub
A neutrophil response linked to tumor control in immunotherapy
Cell
(IF 66.85)
Pub Date : 2023-03-30
Jeremy Gungabeesoon, Nicolas A. Gort-Freitas, Máté Kiss, Evangelia Bolli, Marius Messemaker, Marie Siwicki, Mehdi Hicham, Ruben Bill, Peter Koch, Chiara Cianciaruso, Florent Duval, Christina Pfirschke, Michael Mazzola, Solange Peters, Krisztian Homicsko, Christopher Garris, Ralph Weissleder, Allon M. Klein, Mikael J. Pittet
Negative allosteric modulation of the glucagon receptor by RAMP2
Cell
(IF 66.85)
Pub Date : 2023-03-30
Kaavya Krishna Kumar, Evan S. O’Brien, Chris H. Habrian, Naomi R. Latorraca, Haoqing Wang, Inga Tuneew, Elizabeth Montabana, Susan Marqusee, Daniel Hilger, Ehud Y. Isacoff, Jesper Mosolff Mathiesen, Brian K. Kobilka
Large neutral amino acid levels tune perinatal neuronal excitability and survival
Cell
(IF 66.85)
Pub Date : 2023-03-29
Lisa S. Knaus, Bernadette Basilico, Daniel Malzl, Maria Gerykova Bujalkova, Mateja Smogavec, Lena A. Schwarz, Sarah Gorkiewicz, Nicole Amberg, Florian M. Pauler, Christian Knittl-Frank, Marianna Tassinari, Nuno Maulide, Thomas Rülicke, Jörg Menche, Simon Hippenmeyer, Gaia Novarino
Human T cell generation is restored in CD3δ severe combined immunodeficiency through adenine base editing
Cell
(IF 66.85)
Pub Date : 2023-03-20
Grace E. McAuley, Gloria Yiu, Patrick C. Chang, Gregory A. Newby, Beatriz Campo-Fernandez, Sorel T. Fitz-Gibbon, Xiaomeng Wu, Sung-Hae L. Kang, Amber Garibay, Jeffrey Butler, Valentina Christian, Ryan L. Wong, Kelcee A. Everette, Anthony Azzun, Hila Gelfer, Christopher S. Seet, Aru Narendran, Luis Murguia-Favela, Zulema Romero, Nicola Wright, Donald B. Kohn
Dynamic CD8+ T cell responses to cancer immunotherapy in human regional lymph nodes are disrupted in metastatic lymph nodes
Cell
(IF 66.85)
Pub Date : 2023-03-16
Maha K. Rahim, Trine Line H. Okholm, Kyle B. Jones, Elizabeth E. McCarthy, Candace C. Liu, Jacqueline L. Yee, Stanley J. Tamaki, Diana M. Marquez, Iliana Tenvooren, Katherine Wai, Alexander Cheung, Brittany R. Davidson, Vrinda Johri, Bushra Samad, William E. O’Gorman, Matthew F. Krummel, Annemieke van Zante, Alexis J. Combes, Michael Angelo, Lawrence Fong, Matthew H. Spitzer
HIV-1 remission and possible cure in a woman after haplo-cord blood transplant
Cell
(IF 66.85)
Pub Date : 2023-03-16
Jingmei Hsu, Koen Van Besien, Marshall J. Glesby, Savita Pahwa, Anne Coletti, Meredith G. Warshaw, Larry Petz, Theodore B. Moore, Ya Hui Chen, Suresh Pallikkuth, Adit Dhummakupt, Ruth Cortado, Amanda Golner, Frederic Bone, Maria Baldo, Marcie Riches, John W. Mellors, Nicole H. Tobin, Renee Browning, Deborah Persaud, Dwight Yin
Single substitution in H3.3G34 alters DNMT3A recruitment to cause progressive neurodegeneration
Cell
(IF 66.85)
Pub Date : 2023-03-16
Sima Khazaei, Carol C.L. Chen, Augusto Faria Andrade, Nisha Kabir, Pariya Azarafshar, Shahir M. Morcos, Josiane Alves França, Mariana Lopes, Peder J. Lund, Geoffroy Danieau, Samantha Worme, Lata Adnani, Nadine Nzirorera, Xiao Chen, Gayathri Yogarajah, Caterina Russo, Michele Zeinieh, Cassandra J. Wong, Laura Bryant, Steven Hébert, Nada Jabado
Whole-genome sequencing reveals a complex African population demographic history and signatures of local adaptation
Cell
(IF 66.85)
Pub Date : 2023-03-02
Shaohua Fan, Jeffrey P. Spence, Yuanqing Feng, Matthew E.B. Hansen, Jonathan Terhorst, Marcia H. Beltrame, Alessia Ranciaro, Jibril Hirbo, William Beggs, Neil Thomas, Thomas Nyambo, Sununguko Wata Mpoloka, Gaonyadiwe George Mokone, Alfred Njamnshi, Charles Folkunang, Dawit Wolde Meskel, Gurja Belay, Yun S. Song, Sarah A. Tishkoff
Biophysical forces mediated by respiration maintain lung alveolar epithelial cell fate
Cell
(IF 66.85)
Pub Date : 2023-03-03
Kazushige Shiraishi, Parisha P. Shah, Michael P. Morley, Claudia Loebel, Garrett T. Santini, Jeremy Katzen, Maria C. Basil, Susan M. Lin, Joseph D. Planer, Edward Cantu, Dakota L. Jones, Ana N. Nottingham, Shanru Li, Fabian L. Cardenas-Diaz, Su Zhou, Jason A. Burdick, Rajan Jain, Edward E. Morrisey
Apoptotic cell fragments locally activate tingible body macrophages in the germinal center
Cell
(IF 66.85)
Pub Date : 2023-03-02
Abigail K. Grootveld, Wunna Kyaw, Veera Panova, Angelica W.Y. Lau, Emily Ashwin, Guillaume Seuzaret, Rama Dhenni, Nayan Deger Bhattacharyya, Weng Hua Khoo, Maté Biro, Tanmay Mitra, Michael Meyer-Hermann, Patrick Bertolino, Masato Tanaka, David A. Hume, Peter I. Croucher, Robert Brink, Akira Nguyen, Oliver Bannard, Tri Giang Phan
Cell lineage-specific mitochondrial resilience during mammalian organogenesis
Cell
(IF 66.85)
Pub Date : 2023-02-23
Stephen P. Burr, Florian Klimm, Angelos Glynos, Malwina Prater, Pamella Sendon, Pavel Nash, Christopher A. Powell, Marie-Lune Simard, Nina A. Bonekamp, Julia Charl, Hector Diaz, Lyuba V. Bozhilova, Yu Nie, Haixin Zhang, Michele Frison, Maria Falkenberg, Nick Jones, Michal Minczuk, James B. Stewart, Patrick F. Chinnery
Bat pluripotent stem cells reveal unusual entanglement between host and viruses
Cell
(IF 66.85)
Pub Date : 2023-02-21
Marion Déjosez, Arturo Marin, Graham M. Hughes, Ariadna E. Morales, Carlos Godoy-Parejo, Jonathan L. Gray, Yiren Qin, Arun A. Singh, Hui Xu, Javier Juste, Carlos Ibáñez, Kris M. White, Romel Rosales, Nancy J. Francoeur, Robert P. Sebra, Dominic Alcock, Thomas L. Volkert, Sébastien J. Puechmaille, Andrzej Pastusiak, Simon D.W. Frost, Thomas P. Zwaka