Genomics research has thrived under a culture of data sharing, formalized during the genome-project era. As the field’s complexity has increased to the population scale this culture risks being eroded, yet the core principles still apply. The community would benefit from more open discussion and consensus-building around biological data sharing, recognizing that the answer will shape what the practice

Spatial transcriptomics tools enable the detection and localization of hundreds to thousands of transcripts in biological tissues. However, most technologies are not designed to detect microRNAs. Existing technologies should be expanded to incorporate these key molecular regulators and enable more-comprehensive transcriptomic studies that will shape the new field of spatial miRNomics. In this Comment

Addressing ethical, legal and social implications (ELSI) in genomics requires early integration of specialized teams to enhance community engagement, address disparities and promote health equity. Lessons learnt from the human Developmental Genotype-Tissue Expression (dGTEx) project show how implementing a collaborative framework can support genomic discovery. The promise of paediatric genomics depends

Ayako Suzuki recalls two papers published in the early 2000s by the Functional Annotation of the Mammalian Genome (FANTOM) consortium and the Full-Length Long Japan (FLJ) project, which provided reference catalogues of full-length transcripts in mice and humans, respectively.

In this Journal Club, Mariana Boroni recalls a 2012 study by Gerlinger et al. that revealed the complex and branched evolution of cancer and challenged the prevailing view of linear tumour progression.

Xiu-Fang Xin recalls several papers that described one of the most influential and widely accepted examples of indirect activation of nucleotide-binding, leucine-rich repeat receptors in plants.

Challenges in the development of treatments for hereditary hearing loss include the exploration of the underlying pathological mechanisms, the comprehensive evaluation of safety and efficacy of gene therapies in clinical trials, the optimization of surgical approaches for drug delivery, and effective collaboration between industry and academia. Gene therapy for congenital deafness has made a breakthrough

Natural history collections are unparalleled resources for studying biodiversity across multiple dimensions. As multi-omic tools are being applied to museum specimens, the emerging field of museomics is undergoing a rapid and exciting transformation, with new opportunities, challenges and confrontations with past legacies. In this Comment, the authors showcase how the emerging field of museomics —

Abderrahman Khila highlights an important 2015 paper by Barson et al. that demonstrated how sexual conflict in Atlantic salmon affects genetic evolution.

Lingzhao Fang recalls how a 2002 paper by Brem et al., which investigated the genetic basis of natural variation in gene expression in budding yeast, and the GTEx atlas of genetic regulatory effects across human tissues inspired the FarmGTEx project to accelerate precision agriculture.

In this Journal Club, Julie Jung and Thomas King recount a paper by Chan et al. that identified the regulatory changes underlying recurrent phenotypic evolution in stickleback fish.

In this Journal Club, Julia Horsfield recounts two papers that demonstrated how cohesin and CTCF together organize the genome and regulate gene expression.

In this Journal Club, Pleuni Pennings recalls two papers that connected the evolutionary dynamics of HIV variants with therapeutic outcomes, illustrating how evolutionary insights can inform public health decisions.

Cloud platforms offer distinct advantages, but questions remain about how to ethically and efficiently manage human genomic data in the cloud. Data governance needs to be adapted to ensure transparency and security for research participants, as well as equitable and sustainable access for researchers. Rahimzadeh et al. discuss the ethical, legal and social implications of storing and analysing human

In this Journal Club, Berna Sozen recalls the metabolic gradient theory proposed by Charles Manning Child in the early 20th century, which posited that metabolic gradients drive cellular differentiation and tissue patterning.

In this Journal Club, Shila Ghazanfar highlights a seminal paper by Levsky et al. that paved the way for contemporary single-cell spatial transcriptomics.

In this Journal Club article, Edroaldo Lummertz da Rocha discusses two papers that provided important insights into how tumour cells communicate with distant organs to establish pre-metastatic niches.

In this Journal Club, Shengbao Suo highlights two publications that underscore the importance of genetic regulation of endogenous retrovirus expression in tumours.

Bolognini et al. report evidence of positive selection for human amylase gene duplications associated with the agricultural revolution.

The adoption of microfluidics was fundamental to the development of cost-effective, high-throughput DNA sequencing. As the field progresses towards multi-omics, we reflect on the key concepts underlying microfluidics and how resulting engineering advances at the microscale drove the evolution of genomic sequencing. The adoption of microfluidics was fundamental to the development of cost-effective,

In this Journal Club, Alejo Rodriguez-Fratelli discusses a paper by Spudich and Koshland Jr that characterized non-genetic cell individuality in bacteria, a concept with emerging relevance to cancer progression.

A study in Science investigating bacterial defence mechanisms against phages reports a novel mode of gene regulation through reverse transcription of a non-coding RNA template, leading to the formation of a toxic repetitive gene.

Yimiao Qu and Kyle Loh discuss a 2004 paper by Xie et al., who demonstrated that B cells can be reprogrammed into macrophages through the enforced expression of a single transcription factor, providing insights into cellular plasticity and lineage conversion.

The widespread use of medically assisted reproduction fosters the false impression that the underlying causes of male infertility are not important to know. However, to improve men’s reproductive and long-term health, as well as the health of their offspring, large-scale genetic studies are essential. Thus, reproductive genomics should be implemented in diagnostics as soon as possible. In this Comment

Merly C. Vogt recalls a seminal paper by Greer et al., who demonstrated the transgenerational inheritance of longevity, a complex trait, in Caenorhabditis elegans by manipulating the trimethylation of histone H3 lysine 4 (H3K4me3) in the parental generation.

Satterlee et al. employ several approaches to demonstrate that prickle evolution has a common genetic basis among several plant lineages.

Duttke et al. show that transcription factors have position-dependent effects relative to their distance from the transcription start site, which suggests that a 'spatial grammar' could be used to encode multiple gene-regulatory programmes.

Neumann, Bertozzi et al. describe a novel epigenetic editor termed CHARM and report its use to silence prion protein expression in the brain.

Two studies in Nature reveal the mechanistic and structural properties of a family of mobile genetic elements that can be reprogrammed to engineer genome modifications.