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Lineage tracing meets single-cell omics: opportunities and challenges Nat. Rev. Genet. (IF 43.704) Pub Date : 2020-03-31 Daniel E. Wagner; Allon M. Klein
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Electronic health records and polygenic risk scores for predicting disease risk Nat. Rev. Genet. (IF 43.704) Pub Date : 2020-03-31 Ruowang Li; Yong Chen; Marylyn D. Ritchie; Jason H. Moore
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Deciphering the impact of enhancer variation Nat. Rev. Genet. (IF 43.704) Pub Date : 2020-03-20 Joseph Willson
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Transcriptional profiling of physically interacting cells Nat. Rev. Genet. (IF 43.704) Pub Date : 2020-03-18 Linda Koch
A new technology, named PIC-seq, combines cell sorting of physically interacting cells (PICs) with single-cell RNA sequencing and computational modelling to profile cellular interactions and their impact on gene expression.
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Beyond broad strokes: sociocultural insights from the study of ancient genomes. Nat. Rev. Genet. (IF 43.704) Pub Date : 2020-03-03 Fernando Racimo,Martin Sikora,Marc Vander Linden,Hannes Schroeder,Carles Lalueza-Fox
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There and back again - ancient genes reveal early migrations. Nat. Rev. Genet. (IF 43.704) Pub Date : 2020-02-25 Joseph Willson
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Improving bee health through genomics. Nat. Rev. Genet. (IF 43.704) Pub Date : 2020-02-25 Christina M Grozinger,Amro Zayed
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Transcriptomics of developmental fate. Nat. Rev. Genet. (IF 43.704) Pub Date : 2020-02-21 Darren J Burgess
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Optogenetic control of single mRNA spatiotemporal dynamics. Nat. Rev. Genet. (IF 43.704) Pub Date : 2020-02-19 Linda Koch
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A systems approach to infectious disease. Nat. Rev. Genet. (IF 43.704) Pub Date : 2020-02-14 Manon Eckhardt,Judd F Hultquist,Robyn M Kaake,Ruth Hüttenhain,Nevan J Krogan
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Conserved chromosomal functions of RNA interference. Nat. Rev. Genet. (IF 43.704) Pub Date : 2020-02-12 Michael J Gutbrod,Robert A Martienssen
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Engineering adeno-associated virus vectors for gene therapy. Nat. Rev. Genet. (IF 43.704) Pub Date : 2020-02-10 Chengwen Li,R Jude Samulski
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Pan-genomics in the human genome era. Nat. Rev. Genet. (IF 43.704) Pub Date : 2020-02-07 Rachel M Sherman,Steven L Salzberg
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A means to an end for transcription? Nat. Rev. Genet. (IF 43.704) Pub Date : 2020-01-29 Darren J Burgess
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Selling direct-to-consumer epigenetic tests: are we ready? Nat. Rev. Genet. (IF 43.704) Pub Date : 2020-01-28 Charles Dupras,Elisabeth Beauchamp,Yann Joly
Private companies have recently started to sell epigenetic tests to the public online, most of them without supervision by a physician. While the ethical and legal implications of direct-to-consumer genetic testing have received considerable attention over the past decades, other direct-to-consumer ‘omic’ tests have largely escaped scrutiny. Direct-to-consumer epigenetic tests have the potential to
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Omics and organoids - a route to improved anti-venom. Nat. Rev. Genet. (IF 43.704) Pub Date : 2020-01-28 Dorothy Clyde
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A primate view of gene expression. Nat. Rev. Genet. (IF 43.704) Pub Date : 2020-01-28 Linda Koch
A Genome Research study reports gene expression and DNA methylation profiles of multiple tissues sampled from the same individuals across humans, chimpanzees and rhesus macaques.
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Towards a comprehensive catalogue of validated and target-linked human enhancers. Nat. Rev. Genet. (IF 43.704) Pub Date : 2020-01-27 Molly Gasperini,Jacob M Tome,Jay Shendure
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Multi-omics shows the (default) way. Nat. Rev. Genet. (IF 43.704) Pub Date : 2020-01-10 Joseph Willson
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Mechanisms of tissue and cell-type specificity in heritable traits and diseases. Nat. Rev. Genet. (IF 43.704) Pub Date : 2020-01-08 Idan Hekselman,Esti Yeger-Lotem
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Methods for mapping 3D chromosome architecture. Nat. Rev. Genet. (IF 43.704) Pub Date : 2019-12-17 Rieke Kempfer,Ana Pombo
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Overcoming challenges and dogmas to understand the functions of pseudogenes. Nat. Rev. Genet. (IF 43.704) Pub Date : 2019-12-17 Seth W Cheetham,Geoffrey J Faulkner,Marcel E Dinger
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Expanding applications for nanopore sequencing. Nat. Rev. Genet. (IF 43.704) Pub Date : 2020-02-01 Darren J Burgess
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From a distance - gene regulation in plants. Nat. Rev. Genet. (IF 43.704) Pub Date : 2020-02-01 Dorothy Clyde
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Cell-free gene expression: an expanded repertoire of applications. Nat. Rev. Genet. (IF 43.704) Pub Date : 2019-11-28 Adam D Silverman,Ashty S Karim,Michael C Jewett
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Chromosome organization in bacteria: mechanistic insights into genome structure and function Nat. Rev. Genet. (IF 43.704) Pub Date : 2019-11-25 Remus T. Dame, Fatema-Zahra M. Rashid, David C. Grainger
Bacterial chromosomes are folded to compact DNA and facilitate cellular processes. Studying model bacteria has revealed aspects of chromosome folding that are applicable to many species. Primarily controlled by nucleoid-associated proteins, chromosome folding is hierarchical, from large-scale macrodomains to smaller-scale structures that influence DNA transactions, including replication and transcription
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DNA sensing by the cGAS-STING pathway in health and disease. Nat. Rev. Genet. (IF 43.704) Pub Date : 2019-07-29 Mona Motwani,Scott Pesiridis,Katherine A Fitzgerald
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RNA sequencing: the teenage years. Nat. Rev. Genet. (IF 43.704) Pub Date : 2019-07-24 Rory Stark,Marta Grzelak,James Hadfield
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Overvaluing individual consent ignores risks to tribal participants. Nat. Rev. Genet. (IF 43.704) Pub Date : 2019-07-15 Krystal S Tsosie,Joseph M Yracheta,Donna Dickenson
Genomic studies often rely on individual-based consent approaches for tribal members residing outside of their communities. This consent model fails to acknowledge the risks to small groups such as tribes, which can implicate the community as a whole. Genomic studies often rely on individual-based consent approaches for tribal members residing outside of their communities. Tsosie et al. argue that
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The potential of genomics for restoring ecosystems and biodiversity. Nat. Rev. Genet. (IF 43.704) Pub Date : 2019-07-12 Martin F Breed,Peter A Harrison,Colette Blyth,Margaret Byrne,Virginie Gaget,Nicholas J C Gellie,Scott V C Groom,Riley Hodgson,Jacob G Mills,Thomas A A Prowse,Dorothy A Steane,Jakki J Mohr
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Making the case for more inclusive GWAS. Nat. Rev. Genet. (IF 43.704) Pub Date : 2019-09-01 Dorothy Clyde
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Author Correction: Chromatin-associated RNAs as facilitators of functional genomic interactions Nat. Rev. Genet. (IF 43.704) Pub Date : 2019-07-04 Xiao Li, Xiang-Dong Fu
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Author Correction: Genomics of disease risk in globally diverse populations Nat. Rev. Genet. (IF 43.704) Pub Date : 2019-07-03 Deepti Gurdasani, Inês Barroso, Eleftheria Zeggini, Manjinder S. Sandhu
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Optoepigenetics for 3D genome engineering. Nat. Rev. Genet. (IF 43.704) Pub Date : 2019-09-01 Linda Koch
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Alternative cleavage and polyadenylation in health and disease. Nat. Rev. Genet. (IF 43.704) Pub Date : 2019-07-02 Andreas J Gruber,Mihaela Zavolan
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Author Correction: The role of sex in the genomics of human complex traits Nat. Rev. Genet. (IF 43.704) Pub Date : 2019-06-28 Ekaterina A. Khramtsova, Lea K. Davis, Barbara E. Stranger
In Box 4 of the originally published article, the text describing the Miami plot in part c of the figure contained some minor errors. Specifically, during pre-publication revision of the article, the authors updated the illustrative Miami plot (shown in figure part c) from that of reference 80 (Randall et al. PLoS Genet. (2013)) to a more recent study in reference 82 (Winkler et al. PLoS Genet. (2015))
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Genomics of disease risk in globally diverse populations. Nat. Rev. Genet. (IF 43.704) Pub Date : 2019-06-24 Deepti Gurdasani,Inês Barroso,Eleftheria Zeggini,Manjinder S Sandhu
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Somatic genetic rescue in Mendelian haematopoietic diseases. Nat. Rev. Genet. (IF 43.704) Pub Date : 2019-06-11 Patrick Revy,Caroline Kannengiesser,Alain Fischer
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Structural variation in the sequencing era. Nat. Rev. Genet. (IF 43.704) Pub Date : 2019-11-15 Steve S Ho,Alexander E Urban,Ryan E Mills
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Regulation of gene expression by cis-acting long non-coding RNAs. Nat. Rev. Genet. (IF 43.704) Pub Date : 2019-11-15 Noa Gil,Igor Ulitsky
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The genetics of human ageing. Nat. Rev. Genet. (IF 43.704) Pub Date : 2019-11-05 David Melzer,Luke C Pilling,Luigi Ferrucci
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A statistical framework for rare disease diagnosis Nat. Rev. Genet. (IF 43.704) Pub Date : 2019-11-01 Conor A. Bradley
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Decoding cancer immunology: Hunting hidden tumours. Nat. Rev. Genet. (IF 43.704) Pub Date : 2019-11-07
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Towards models of disease pathogenesis from diverse genetic causes. Nat. Rev. Genet. (IF 43.704) Pub Date : 2011-04-14
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Reply to 'A different perspective on alternative cleavage and polyadenylation'. Nat. Rev. Genet. (IF 43.704) Pub Date : null Andreas J Gruber,Mihaela Zavolan
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