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  • SHARE-seq reveals chromatin potential
    Nat. Rev. Genet. (IF 33.133) Pub Date : 2020-11-17
    Dorothy Clyde

    SHARE-seq, a new high-throughput, high-resolution multi-omics method described in Cell, measures chromatin accessibility and gene expression in the same cell and enables future potential gene expression (and therefore lineage choices) to be inferred from chromatin profiles.

    更新日期:2020-11-17
  • The epitranscriptome beyond m 6 A
    Nat. Rev. Genet. (IF 33.133) Pub Date : 2020-11-13
    David Wiener; Schraga Schwartz

    Following its transcription, RNA can be modified by >170 chemically distinct types of modifications — the epitranscriptome. In recent years, there have been substantial efforts to uncover and characterize the modifications present on mRNA, motivated by the potential of such modifications to regulate mRNA fate and by discoveries and advances in our understanding of N6-methyladenosine (m6A). Here, we

    更新日期:2020-11-13
  • Deciphering cell–cell interactions and communication from gene expression
    Nat. Rev. Genet. (IF 33.133) Pub Date : 2020-11-09
    Erick Armingol; Adam Officer; Olivier Harismendy; Nathan E. Lewis

    Cell–cell interactions orchestrate organismal development, homeostasis and single-cell functions. When cells do not properly interact or improperly decode molecular messages, disease ensues. Thus, the identification and quantification of intercellular signalling pathways has become a common analysis performed across diverse disciplines. The expansion of protein–protein interaction databases and recent

    更新日期:2020-11-09
  • Nucleic-acid sequencing of proteomes
    Nat. Rev. Genet. (IF 33.133) Pub Date : 2020-10-23
    Linda Koch

    A recent study re-casts proteomic analyses as a DNA sequencing problem; by fusing in vivo-expressed proteins to their encoding mRNA, molecular interactions can be identified and quantified through high-throughput nucleic-acid sequencing.

    更新日期:2020-10-28
  • The importance of genomic variation for biodiversity, ecosystems and people
    Nat. Rev. Genet. (IF 33.133) Pub Date : 2020-10-16
    Madlen Stange; Rowan D. H. Barrett; Andrew P. Hendry

    The 2019 United Nations Global assessment report on biodiversity and ecosystem services estimated that approximately 1 million species are at risk of extinction. This primarily human-driven loss of biodiversity has unprecedented negative consequences for ecosystems and people. Classic and emerging approaches in genetics and genomics have the potential to dramatically improve these outcomes. In particular

    更新日期:2020-10-17
  • Reaching completion for GTEx
    Nat. Rev. Genet. (IF 33.133) Pub Date : 2020-10-15
    Darren J. Burgess

    The GTEx consortium reports results from its third and final phase in several new papers. They provide unprecedented detail of human gene expression regulation across tissues.

    更新日期:2020-10-16
  • Abuzz with bumblebee genomes
    Nat. Rev. Genet. (IF 33.133) Pub Date : 2020-10-09
    Dorothy Clyde

    A study in Molecular Biology and Evolution reports de novo genome sequences for 17 bumblebee species spanning all 15 subgenera. This valuable resource should provide a deeper biological understanding of these commercially and ecologically important pollinators.

    更新日期:2020-10-11
  • Active turnover of DNA methylation during cell fate decisions
    Nat. Rev. Genet. (IF 33.133) Pub Date : 2020-10-06
    Aled Parry; Steffen Rulands; Wolf Reik

    DNA methylation is a key layer of epigenetic regulation. The deposition of methylation marks relies on the catalytic activity of DNA methyltransferases (DNMTs), and their active removal relies on the activity of ten–eleven translocation (TET) enzymes. Paradoxically, in important biological contexts these antagonistic factors are co-expressed and target overlapping genomic regions. The ensuing cyclic

    更新日期:2020-10-07
  • African cattle adaptations
    Nat. Rev. Genet. (IF 33.133) Pub Date : 2020-10-05
    Linda Koch

    A study in Nature Genetics reports the analysis of 172 whole-genome sequences of indigenous African cattle and identifies loci associated with environmental adaptations among crossbred animals.

    更新日期:2020-10-05
  • Extreme heterogeneity of human mitochondrial DNA from organelles to populations
    Nat. Rev. Genet. (IF 33.133) Pub Date : 2020-09-28
    James B. Stewart; Patrick F. Chinnery

    Contrary to the long-held view that most humans harbour only identical mitochondrial genomes, deep resequencing has uncovered unanticipated extreme genetic variation within mitochondrial DNA (mtDNA). Most, if not all, humans contain multiple mtDNA genotypes (heteroplasmy); specific patterns of variants accumulate in different tissues, including cancers, over time; and some variants are preferentially

    更新日期:2020-09-28
  • Author Correction: The evolving metabolic landscape of chromatin biology and epigenetics.
    Nat. Rev. Genet. (IF 33.133) Pub Date : 2020-09-25
    Ziwei Dai,Vijyendra Ramesh,Jason W Locasale

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

    更新日期:2020-09-25
  • Enhancing regeneration.
    Nat. Rev. Genet. (IF 33.133) Pub Date : 2020-09-22
    Katharine H Wrighton

    A study in Science suggests that regeneration-responsive enhancers drive a regeneration response programme (RRP) in killifish and zebrafish and that changes in RRPs might have facilitated the loss of regenerative capacity in vertebrates.

    更新日期:2020-09-22
  • COMPASS and SWI/SNF complexes in development and disease.
    Nat. Rev. Genet. (IF 33.133) Pub Date : 2020-09-21
    Bercin K Cenik,Ali Shilatifard

    The Trithorax group (TrxG) of proteins is a large family of epigenetic regulators that form multiprotein complexes to counteract repressive developmental gene expression programmes established by the Polycomb group of proteins and to promote and maintain an active state of gene expression. Recent studies are providing new insights into how two crucial families of the TrxG — the COMPASS family of histone

    更新日期:2020-09-21
  • Exploring the genetic basis of blood cell traits.
    Nat. Rev. Genet. (IF 33.133) Pub Date : 2020-09-17
    Dorothy Clyde

    Two papers in Cell report large-scale genome-wide association studies that provide new insights into the genetic architecture of haematopoietic phenotypes and emphasize the importance of large, diverse data sets.

    更新日期:2020-09-18
  • African ancient DNA research requires robust ethics and permission protocols.
    Nat. Rev. Genet. (IF 33.133) Pub Date : 2020-09-16
    Victoria E Gibbon

    In Africa, there is a disparity in ethics and permission requirements for molecular research on samples from living people versus ancient DNA. At the precipice of the archaeogenomics revolution, heritage agencies require updated policies and procedures for genetic and genomic research on African ancient DNA.

    更新日期:2020-09-16
  • Marking a milestone.
    Nat. Rev. Genet. (IF 33.133) Pub Date : 2020-09-14

    As Nature Reviews Genetics turns 20 years, the editors embrace the opportunity to pause and reflect on the past, take stock of the present and look to the future. Please join us in celebrating our Anniversary issue.

    更新日期:2020-09-14
  • The evolving metabolic landscape of chromatin biology and epigenetics.
    Nat. Rev. Genet. (IF 33.133) Pub Date : 2020-09-09
    Ziwei Dai,Vijyendra Ramesh,Jason W Locasale

    Molecular inputs to chromatin via cellular metabolism are modifiers of the epigenome. These inputs — which include both nutrient availability as a result of diet and growth factor signalling — are implicated in linking the environment to the maintenance of cellular homeostasis and cell identity. Recent studies have demonstrated that these inputs are much broader than had previously been known, encompassing

    更新日期:2020-09-10
  • Tracing chromatin architecture.
    Nat. Rev. Genet. (IF 33.133) Pub Date : 2020-09-02
    Linda Koch

    A study in Cell presents a new approach that increases resolution and throughput compared with existing imaging methods and provides insights into the relationship between transcription and the 3D genome.

    更新日期:2020-09-02
  • Host-parasite co-evolution and its genomic signature.
    Nat. Rev. Genet. (IF 33.133) Pub Date : 2020-08-28
    Dieter Ebert,Peter D Fields

    Studies in diverse biological systems have indicated that host–parasite co-evolution is responsible for the extraordinary genetic diversity seen in some genomic regions, such as major histocompatibility (MHC) genes in jawed vertebrates and resistance genes in plants. This diversity is believed to evolve under balancing selection on hosts by parasites. However, the mechanisms that link the genomic signatures

    更新日期:2020-08-29
  • Author Correction: Emerging mechanisms of cell competition.
    Nat. Rev. Genet. (IF 33.133) Pub Date : 2020-08-28
    Nicholas E Baker

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

    更新日期:2020-08-28
  • Genetics meets proteomics: perspectives for large population-based studies.
    Nat. Rev. Genet. (IF 33.133) Pub Date : 2020-08-28
    Karsten Suhre,Mark I McCarthy,Jochen M Schwenk

    Proteomic analysis of cells, tissues and body fluids has generated valuable insights into the complex processes influencing human biology. Proteins represent intermediate phenotypes for disease and provide insight into how genetic and non-genetic risk factors are mechanistically linked to clinical outcomes. Associations between protein levels and DNA sequence variants that colocalize with risk alleles

    更新日期:2020-08-28
  • The road ahead in genetics and genomics.
    Nat. Rev. Genet. (IF 33.133) Pub Date : 2020-08-24
    Amy L McGuire,Stacey Gabriel,Sarah A Tishkoff,Ambroise Wonkam,Aravinda Chakravarti,Eileen E M Furlong,Barbara Treutlein,Alexander Meissner,Howard Y Chang,Núria López-Bigas,Eran Segal,Jin-Soo Kim

    In celebration of the 20th anniversary of Nature Reviews Genetics, we asked 12 leading researchers to reflect on the key challenges and opportunities faced by the field of genetics and genomics. Keeping their particular research area in mind, they take stock of the current state of play and emphasize the work that remains to be done over the next few years so that, ultimately, the benefits of genetic

    更新日期:2020-08-25
  • Testing the developing epigenome.
    Nat. Rev. Genet. (IF 33.133) Pub Date : 2020-08-20
    Darren J Burgess

    A recent study combines CRISPR-based perturbation with single-cell RNA sequencing to characterize the roles of epigenome regulator proteins in controlling cell fate and identity during embryonic development.

    更新日期:2020-08-20
  • Accessible disease insights.
    Nat. Rev. Genet. (IF 33.133) Pub Date : 2020-08-18
    Darren J Burgess

    A new study in Science uses chromatin accessibility profiles to reveal gene regulatory alterations associated with genetic variants in neuropsychiatric disease.

    更新日期:2020-08-18
  • Evolutionary insights right off the bat.
    Nat. Rev. Genet. (IF 33.133) Pub Date : 2020-08-18
    Linda Koch

    Reference-quality genomes for six bat species published in Nature yield insights into the evolutionary origins of bats and the molecular basis of adaptive traits involved in immunity and sensory perception.

    更新日期:2020-08-18
  • Integrating genetic and non-genetic determinants of cancer evolution by single-cell multi-omics.
    Nat. Rev. Genet. (IF 33.133) Pub Date : 2020-08-17
    Anna S Nam,Ronan Chaligne,Dan A Landau

    Cancer represents an evolutionary process through which growing malignant populations genetically diversify, leading to tumour progression, relapse and resistance to therapy. In addition to genetic diversity, the cell-to-cell variation that fuels evolutionary selection also manifests in cellular states, epigenetic profiles, spatial distributions and interactions with the microenvironment. Therefore

    更新日期:2020-08-17
  • Killer queens and supergenes.
    Nat. Rev. Genet. (IF 33.133) Pub Date : 2020-08-14
    Dorothy Clyde

    A study in PNAS describes a maternal-effect killer supergene that regulates social behaviour in Alpine silver ants. Queens carrying the ‘killer’ haplotype fail to produce live progeny homozygous for the alternative haplotype, ensuring all colonies adopt a multiple-queen, rather than single-queen, social structure.

    更新日期:2020-08-14
  • Emerging mechanisms of cell competition.
    Nat. Rev. Genet. (IF 33.133) Pub Date : 2020-08-10
    Nicholas E Baker

    The growth and survival of cells within tissues can be affected by ‘cell competition’ between different cell clones. This phenomenon was initially recognized between wild-type cells and cells with mutations in ribosomal protein (Rp) genes in Drosophila melanogaster. However, competition also affects D. melanogaster cells with mutations in epithelial polarity genes, and wild-type cells exposed to ‘super-competitor’

    更新日期:2020-08-10
  • The Human Genome Project changed everything.
    Nat. Rev. Genet. (IF 33.133) Pub Date : 2020-08-07
    Richard A Gibbs

    Thirty years on from the launch of the Human Genome Project, Richard Gibbs reflects on the promises that this voyage of discovery bore. Its success should be measured by how this project transformed the rules of research, the way of practising biological discovery and the ubiquitous digitization of biological science. Thirty years on from the launch of the Human Genome Project, Richard Gibbs reflects

    更新日期:2020-08-08
  • Author Correction: Polygenic adaptation: a unifying framework to understand positive selection.
    Nat. Rev. Genet. (IF 33.133) Pub Date : 2020-08-06
    Neda Barghi,Joachim Hermisson,Christian Schlötterer

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

    更新日期:2020-08-06
  • Lasting cellular memories.
    Nat. Rev. Genet. (IF 33.133) Pub Date : 2020-08-06
    Dorothy Clyde

    A study in Cell introduces memory sequencing (MemorySeq), a method for identifying genes that are highly and heritably expressed over multiple cell divisions. These expression patterns can reveal cellular subpopulations with distinct phenotypes, such as drug resistance.

    更新日期:2020-08-06
  • RNA: a double-edged sword in genome maintenance.
    Nat. Rev. Genet. (IF 33.133) Pub Date : 2020-08-06
    Dali Zong,Philipp Oberdoerffer,Pedro J Batista,André Nussenzweig

    All organisms must safeguard the integrity of their DNA to avoid deleterious consequences of genome instability, which have been linked to human diseases such as autoimmune disorders, neurodegenerative diseases and cancer. Traditionally, genome maintenance has been viewed largely in terms of DNA–protein interactions. However, emerging evidence points to RNA as a key modulator of genome stability, with

    更新日期:2020-08-06
  • A long read of the human genome.
    Nat. Rev. Genet. (IF 33.133) Pub Date : 2020-08-03
    Katharine H Wrighton

    A study in Nature describes the assembly of a human genome with greater continuity than the current reference genome, as well as the assembly of a complete human X chromosome. These assemblies were achieved by combining data generated by different long-read sequencing technologies.

    更新日期:2020-08-03
  • mRNAs, proteins and the emerging principles of gene expression control.
    Nat. Rev. Genet. (IF 33.133) Pub Date : 2020-07-24
    Christopher Buccitelli,Matthias Selbach

    Gene expression involves transcription, translation and the turnover of mRNAs and proteins. The degree to which protein abundances scale with mRNA levels and the implications in cases where this dependency breaks down remain an intensely debated topic. Here we review recent mRNA–protein correlation studies in the light of the quantitative parameters of the gene expression pathway, contextual confounders

    更新日期:2020-07-24
  • Responsible, practical genomic data sharing that accelerates research.
    Nat. Rev. Genet. (IF 33.133) Pub Date : 2020-07-21
    James Brian Byrd,Anna C Greene,Deepashree Venkatesh Prasad,Xiaoqian Jiang,Casey S Greene

    Data sharing anchors reproducible science, but expectations and best practices are often nebulous. Communities of funders, researchers and publishers continue to grapple with what should be required or encouraged. To illuminate the rationales for sharing data, the technical challenges and the social and cultural challenges, we consider the stakeholders in the scientific enterprise. In biomedical research

    更新日期:2020-07-21
  • An odyssey to Oceania.
    Nat. Rev. Genet. (IF 33.133) Pub Date : 2020-07-20
    Linda Koch

    A study in Nature analysing genome-wide variation in individuals from islands across Polynesia reports evidence of admixture with Native Americans related to Indigenous inhabitants of northern South America.

    更新日期:2020-07-21
  • From dog days to human years.
    Nat. Rev. Genet. (IF 33.133) Pub Date : 2020-07-17
    Dorothy Clyde

    Epigenetic clocks translate the DNA methylome into a biological age but usually work only within a species. Now, a study in Cell Systems reports a cross-species epigenetic clock that works across a number of mammals, including humans, dogs and mice.

    更新日期:2020-07-17
  • Redefining fundamental concepts of transcription initiation in bacteria.
    Nat. Rev. Genet. (IF 33.133) Pub Date : 2020-07-14
    Citlalli Mejía-Almonte,Stephen J W Busby,Joseph T Wade,Jacques van Helden,Adam P Arkin,Gary D Stormo,Karen Eilbeck,Bernhard O Palsson,James E Galagan,Julio Collado-Vides

    Despite enormous progress in understanding the fundamentals of bacterial gene regulation, our knowledge remains limited when compared with the number of bacterial genomes and regulatory systems to be discovered. Derived from a small number of initial studies, classic definitions for concepts of gene regulation have evolved as the number of characterized promoters has increased. Together with discoveries

    更新日期:2020-07-14
  • A zipcode for transcriptomes.
    Nat. Rev. Genet. (IF 33.133) Pub Date : 2020-07-13
    Darren J Burgess

    A new study in Nature Methods presents the ‘ZipSeq’ spatial transcriptomics approach, whereby patterned illumination is used to print barcodes onto chosen tissue regions.

    更新日期:2020-07-13
  • Resolving the roles of structural variants.
    Nat. Rev. Genet. (IF 33.133) Pub Date : 2020-07-07
    Joseph Willson

    Structural variants have proved difficult to characterize using traditional sequencing approaches. In two new studies in Cell, the authors demonstrate the use of pan-genome approaches to identify and explore the impact of structural variants in crop genomes and reveal variants linked to specific agronomic traits.

    更新日期:2020-07-07
  • How digital tools can advance quality and equity in genomic medicine.
    Nat. Rev. Genet. (IF 33.133) Pub Date : 2020-06-29
    Yvonne Bombard,Robin Z Hayeems

    Now more than ever, digital applications are essential to accessing genetics services and optimizing their delivery. At this watershed moment, digital solutions must be balanced with the merits of human interaction, without compromising quality or exacerbating existing genomic and technological disparities. As highlighted by the COVID-19 pandemic, digital solutions are becoming essential for the provision

    更新日期:2020-06-29
  • Polygenic adaptation: a unifying framework to understand positive selection.
    Nat. Rev. Genet. (IF 33.133) Pub Date : 2020-06-29
    Neda Barghi,Joachim Hermisson,Christian Schlötterer

    Most adaption processes have a polygenic genetic basis, but even with the recent explosive growth of genomic data we are still lacking a unified framework describing the dynamics of selected alleles. Building on recent theoretical and empirical work we introduce the concept of adaptive architecture, which extends the genetic architecture of an adaptive trait by factors influencing its adaptive potential

    更新日期:2020-06-29
  • Multitasking for base editors.
    Nat. Rev. Genet. (IF 33.133) Pub Date : 2020-06-23
    Darren J Burgess

    Three new studies in Nature Biotechnology combine the adenine and cytosine deaminase activities of single base editors to generate dual base editor systems for combinatorial editing in human cells.

    更新日期:2020-06-23
  • Measuring and interpreting transposable element expression.
    Nat. Rev. Genet. (IF 33.133) Pub Date : 2020-06-23
    Sophie Lanciano,Gael Cristofari

    Transposable elements (TEs) are insertional mutagens that contribute greatly to the plasticity of eukaryotic genomes, influencing the evolution and adaptation of species as well as physiology or disease in individuals. Measuring TE expression helps to understand not only when and where TE mobilization can occur but also how this process alters gene expression, chromatin accessibility or cellular signalling

    更新日期:2020-06-23
  • Sequencing sperm to untangle meiotic variation.
    Nat. Rev. Genet. (IF 33.133) Pub Date : 2020-06-19
    Dorothy Clyde

    A study in Nature describes a new method for studying variation in meiosis. Sperm-seq is a single-cell sequencing approach that enables genome-wide analysis of multiple meiotic phenotypes in thousands of sperm simultaneously.

    更新日期:2020-06-19
  • Discovering and validating cancer genetic dependencies: approaches and pitfalls.
    Nat. Rev. Genet. (IF 33.133) Pub Date : 2020-06-19
    Ann Lin,Jason M Sheltzer

    Cancer ‘genetic dependencies’ — genes whose products are essential for cancer cell fitness — are promising targets for therapeutic development. However, recent evidence has cast doubt on the validity of several putative dependencies that are currently being targeted in cancer clinical trials, underscoring the challenges inherent in correctly identifying cancer-essential genes. Here we review several

    更新日期:2020-06-19
  • A decade of advances in transposon-insertion sequencing.
    Nat. Rev. Genet. (IF 33.133) Pub Date : 2020-06-12
    Amy K Cain,Lars Barquist,Andrew L Goodman,Ian T Paulsen,Julian Parkhill,Tim van Opijnen

    It has been 10 years since the introduction of modern transposon-insertion sequencing (TIS) methods, which combine genome-wide transposon mutagenesis with high-throughput sequencing to estimate the fitness contribution or essentiality of each genetic component in a bacterial genome. Four TIS variations were published in 2009: transposon sequencing (Tn-Seq), transposon-directed insertion site sequencing

    更新日期:2020-06-12
  • Maternal H3K27me3-dependent autosomal and X chromosome imprinting.
    Nat. Rev. Genet. (IF 33.133) Pub Date : 2020-06-08
    Zhiyuan Chen,Yi Zhang

    Genomic imprinting and X-chromosome inactivation (XCI) are classic epigenetic phenomena that involve transcriptional silencing of one parental allele. Germline-derived differential DNA methylation is the best-studied epigenetic mark that initiates imprinting, but evidence indicates that other mechanisms exist. Recent studies have revealed that maternal trimethylation of H3 on lysine 27 (H3K27me3) mediates

    更新日期:2020-06-08
  • Gene regulatory programmes of tissue regeneration.
    Nat. Rev. Genet. (IF 33.133) Pub Date : 2020-06-05
    Joseph A Goldman,Kenneth D Poss

    Regeneration is the process by which organisms replace lost or damaged tissue, and regenerative capacity can vary greatly among species, tissues and life stages. Tissue regeneration shares certain hallmarks of embryonic development, in that lineage-specific factors can be repurposed upon injury to initiate morphogenesis; however, many differences exist between regeneration and embryogenesis. Recent

    更新日期:2020-06-05
  • Long-read human genome sequencing and its applications.
    Nat. Rev. Genet. (IF 33.133) Pub Date : 2020-06-05
    Glennis A Logsdon,Mitchell R Vollger,Evan E Eichler

    Over the past decade, long-read, single-molecule DNA sequencing technologies have emerged as powerful players in genomics. With the ability to generate reads tens to thousands of kilobases in length with an accuracy approaching that of short-read sequencing technologies, these platforms have proven their ability to resolve some of the most challenging regions of the human genome, detect previously

    更新日期:2020-06-05
  • Clone wars: cells competing to win.
    Nat. Rev. Genet. (IF 33.133) Pub Date : 2020-06-05
    Dorothy Clyde

    During ageing, many normal human tissues become a patchwork of mutant clones. Colom et al. show that, in mutagenized mouse oesophageal epithelium, this mutational landscape arises through cell competition, with clone fitness determined by the genotype of their neighbours.

    更新日期:2020-06-05
  • Exploring human genomic diversity with gnomAD.
    Nat. Rev. Genet. (IF 33.133) Pub Date : 2020-06-02
    Linda Koch

    A collection of seven articles from the gnomAD consortium, published in Nature, Nature Medicine and Nature Communications, showcases analyses of global human genetic variation in coding and non-coding genomic regions across this data set.

    更新日期:2020-06-02
  • From molecules to populations: appreciating and estimating recombination rate variation.
    Nat. Rev. Genet. (IF 33.133) Pub Date : 2020-05-29
    Joshua V Peñalba,Jochen B W Wolf

    Recombination is a central biological process with implications for many areas in the life sciences. Yet we are only beginning to appreciate variation in the recombination rate along the genome and among individuals, populations and species. Spurred by technological advances, we are now able to bring variation in this key biological parameter to centre stage. Here, we review the conceptual implications

    更新日期:2020-05-29
  • Haematopoietic stem cell self-renewal in vivo and ex vivo.
    Nat. Rev. Genet. (IF 33.133) Pub Date : 2020-05-28
    Adam C Wilkinson,Kyomi J Igarashi,Hiromitsu Nakauchi

    The self-renewal capacity of multipotent haematopoietic stem cells (HSCs) supports blood system homeostasis throughout life and underlies the curative capacity of clinical HSC transplantation therapies. However, despite extensive characterization of the HSC state in the adult bone marrow and embryonic fetal liver, the mechanism of HSC self-renewal has remained elusive. This Review presents our current

    更新日期:2020-05-28
  • Predicting mRNA levels from genome sequence.
    Nat. Rev. Genet. (IF 33.133) Pub Date : 2020-05-28
    Linda Koch

    A study in Cell Reports describes a machine learning model, named Xpresso, that uses genomic sequence to predict mRNA steady-state abundance.

    更新日期:2020-05-28
  • A mouse with history.
    Nat. Rev. Genet. (IF 33.133) Pub Date : 2020-05-26
    Darren J Burgess

    A new study in Cell describes the CRISPR array repair lineage tracing (CARLIN) engineered mouse line that genomically encodes all the components for CRISPR-based lineage tracking at single-cell resolution.

    更新日期:2020-05-26
  • Publisher Correction: The genomics of coloration provides insights into adaptive evolution.
    Nat. Rev. Genet. (IF 33.133) Pub Date : 2020-05-18
    Anna Orteu,Chris D Jiggins

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

    更新日期:2020-05-18
  • New tools for transcriptome-wide mapping of m6A.
    Nat. Rev. Genet. (IF 33.133) Pub Date : 2020-05-18
    Dorothy Clyde

    Two papers in Nature Chemical Biology describe new methods for transcriptome-mapping of N6-methyladenosine (m6A), a covalent modification of RNA. In m6A-SEAL, modified adenosines can be tagged with different functional groups for different applications, whereas m6A-label-seq uses metabolic labelling to achieve single-nucleotide resolution.

    更新日期:2020-05-18
  • Phylogenetic tree building in the genomic age.
    Nat. Rev. Genet. (IF 33.133) Pub Date : 2020-05-18
    Paschalia Kapli,Ziheng Yang,Maximilian J Telford

    Knowing phylogenetic relationships among species is fundamental for many studies in biology. An accurate phylogenetic tree underpins our understanding of the major transitions in evolution, such as the emergence of new body plans or metabolism, and is key to inferring the origin of new genes, detecting molecular adaptation, understanding morphological character evolution and reconstructing demographic

    更新日期:2020-05-18
  • A platform for RNA virus cloning.
    Nat. Rev. Genet. (IF 33.133) Pub Date : 2020-05-13
    Linda Koch

    A study reports on the suitability of the yeast Saccharomyces cerevisiae as a platform for the assembly and maintenance of diverse RNA virus genomes, including SARS-CoV-2.

    更新日期:2020-05-13
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