当前期刊: Nature Go to current issue    加入关注   
显示样式:        排序: IF: - GO 导出
我的关注
我的收藏
您暂时未登录!
登录
  • Structural basis of CXC chemokine receptor 2 activation and signalling
    Nature (IF 42.778) Pub Date : 2020-07-01
    Kaiwen Liu; Lijie Wu; Shuguang Yuan; Meng Wu; Yueming Xu; Qianqian Sun; Shu Li; Suwen Zhao; Tian Hua; Zhi-Jie Liu

    Chemokines and their receptors mediate cell migration, which influences multiple fundamental biological processes and disease conditions, such as inflammation and cancer1. Although ample efforts have been invested into the structural investigation of the chemokine receptors and receptor–chemokine recognition2–4, less is known about endogenous chemokine-induced receptor activation and G protein coupling

    更新日期:2020-07-01
  • Observation of branched flow of light
    Nature (IF 42.778) Pub Date : 2020-07-01
    Anatoly Patsyk; Uri Sivan; Mordechai Segev; Miguel A. Bandres

    When waves propagate through a weak disordered potential with correlation length larger than the wavelength, they form channels (branches) of enhanced intensity that keep dividing as the waves propagate1. This fundamental wave phenomenon is known as branched flow. It was first observed for electrons1,2,3,4,5,6 and for microwave cavities7,8, and it is generally expected for waves with vastly different

    更新日期:2020-07-01
  • Suppression of proteolipid protein rescues Pelizaeus-Merzbacher disease
    Nature (IF 42.778) Pub Date : 2020-07-01
    Matthew S. Elitt; Lilianne Barbar; H. Elizabeth Shick; Berit E. Powers; Yuka Maeno-Hikichi; Mayur Madhavan; Kevin C. Allan; Baraa S. Nawash; Artur S. Gevorgyan; Stevephen Hung; Zachary S. Nevin; Hannah E. Olsen; Midori Hitomi; Daniela M. Schlatzer; Hien T. Zhao; Adam Swayze; David F. LePage; Weihong Jiang; Ronald A. Conlon; Frank Rigo; Paul J. Tesar

    Mutations in proteolipid protein 1 (PLP1) result in failure of myelination and neurological dysfunction in the X-linked leukodystrophy Pelizaeus-Merzbacher disease (PMD)1,2. Most PLP1 mutations, including point mutations and supernumerary copy variants, lead to severe and fatal disease. PLP1-null patients and mice, however, can display comparatively mild phenotypes, suggesting that PLP1-suppression

    更新日期:2020-07-01
  • Chemical gradients in human enamel crystallites
    Nature (IF 42.778) Pub Date : 2020-07-01
    Karen A. DeRocher; Paul J. M. Smeets; Berit H. Goodge; Michael J. Zachman; Prasanna V. Balachandran; Linus Stegbauer; Michael J. Cohen; Lyle M. Gordon; James M. Rondinelli; Lena F. Kourkoutis; Derk Joester

    Dental enamel is a principal component of teeth1, and has evolved to bear large chewing forces, resist mechanical fatigue and withstand wear over decades2. Functional impairment and loss of dental enamel, caused by developmental defects or tooth decay (caries), affect health and quality of life, with associated costs to society3. Although the past decade has seen progress in our understanding of enamel

    更新日期:2020-07-01
  • Abrupt increase in harvested forest area over Europe after 2015
    Nature (IF 42.778) Pub Date : 2020-07-01
    Guido Ceccherini; Gregory Duveiller; Giacomo Grassi; Guido Lemoine; Valerio Avitabile; Roberto Pilli; Alessandro Cescatti

    Forests provide a series of ecosystem services that are crucial to our society. In the European Union (EU), forests account for approximately 38% of the total land surface1. These forests are important carbon sinks, and their conservation efforts are vital for the EU’s vision of achieving climate neutrality by 20502. However, the increasing demand for forest services and products, driven by the bioeconomy

    更新日期:2020-07-01
  • A remnant planetary core in the hot-Neptune desert
    Nature (IF 42.778) Pub Date : 2020-07-01
    David J. Armstrong; Théo A. Lopez; Vardan Adibekyan; Richard A. Booth; Edward M. Bryant; Karen A. Collins; Magali Deleuil; Alexandre Emsenhuber; Chelsea X. Huang; George W. King; Jorge Lillo-Box; Jack J. Lissauer; Elisabeth Matthews; Olivier Mousis; Louise D. Nielsen; Hugh Osborn; Jon Otegi; Nuno C. Santos; Sérgio G. Sousa; Keivan G. Stassun; Dimitri Veras; Carl Ziegler; Jack S. Acton; Jose M. Almenara;

    The interiors of giant planets remain poorly understood. Even for the planets in the Solar System, difficulties in observation lead to large uncertainties in the properties of planetary cores. Exoplanets that have undergone rare evolutionary processes provide a route to understanding planetary interiors. Planets found in and near the typically barren hot-Neptune ‘desert’1,2 (a region in mass–radius

    更新日期:2020-07-01
  • Structural cells are key regulators of organ-specific immune responses
    Nature (IF 42.778) Pub Date : 2020-07-01
    Thomas Krausgruber; Nikolaus Fortelny; Victoria Fife-Gernedl; Martin Senekowitsch; Linda C. Schuster; Alexander Lercher; Amelie Nemc; Christian Schmidl; André F. Rendeiro; Andreas Bergthaler; Christoph Bock

    The mammalian immune system implements a remarkably effective set of mechanisms for fighting pathogens1. Its main components are haematopoietic immune cells, including myeloid cells that control innate immunity, and lymphoid cells that constitute adaptive immunity2. However, immune functions are not unique to haematopoietic cells, and many other cell types display basic mechanisms of pathogen defence3

    更新日期:2020-07-01
  • Clinical targeting of HIV capsid protein with a long-acting small molecule
    Nature (IF 42.778) Pub Date : 2020-07-01
    John O. Link; Martin S. Rhee; Winston C. Tse; Jim Zheng; John R. Somoza; William Rowe; Rebecca Begley; Anna Chiu; Andrew Mulato; Derek Hansen; Eric Singer; Luong K. Tsai; Rujuta A. Bam; Chien-Hung Chou; Eda Canales; Gediminas Brizgys; Jennifer R. Zhang; Jiayao Li; Michael Graupe; Philip Morganelli; Qi Liu; Qiaoyin Wu; Randall L. Halcomb; Roland D. Saito; Scott D. Schroeder; Scott E. Lazerwith; Steven

    Oral antiretroviral agents provide life-saving treatments for millions of people living with HIV, and can prevent new infections via pre-exposure prophylaxis1,2,3,4,5. However, some people living with HIV who are heavily treatment-experienced have limited or no treatment options, owing to multidrug resistance6. In addition, suboptimal adherence to oral daily regimens can negatively affect the outcome

    更新日期:2020-07-01
  • Laser picoscopy of valence electrons in solids
    Nature (IF 42.778) Pub Date : 2020-07-01
    H. Lakhotia; H. Y. Kim; M. Zhan; S. Hu; S. Meng; E. Goulielmakis

    Valence electrons contribute a small fraction of the total electron density of materials, but they determine their essential chemical, electronic and optical properties. Strong laser fields can probe electrons in valence orbitals1,2,3 and their dynamics4,5,6 in the gas phase. Previous laser studies of solids have associated high-harmonic emission7,8,9,10,11,12 with the spatial arrangement of atoms

    更新日期:2020-07-01
  • Extensive signal integration by the phytohormone protein network
    Nature (IF 42.778) Pub Date : 2020-07-01
    Melina Altmann; Stefan Altmann; Patricia A. Rodriguez; Benjamin Weller; Lena Elorduy Vergara; Julius Palme; Nora Marín-de la Rosa; Mayra Sauer; Marion Wenig; José Antonio Villaécija-Aguilar; Jennifer Sales; Chung-Wen Lin; Ramakrishnan Pandiarajan; Veronika Young; Alexandra Strobel; Lisa Gross; Samy Carbonnel; Karl G. Kugler; Antoni Garcia-Molina; George W. Bassel; Claudia Falter; Klaus F. X. Mayer;

    Plant hormones coordinate responses to environmental cues with developmental programs1, and are fundamental for stress resilience and agronomic yield2. The core signalling pathways underlying the effects of phytohormones have been elucidated by genetic screens and hypothesis-driven approaches, and extended by interactome studies of select pathways3. However, fundamental questions remain about how information

    更新日期:2020-07-01
  • Systematic quantitative analysis of ribosome inventory during nutrient stress
    Nature (IF 42.778) Pub Date : 2020-07-01
    Heeseon An; Alban Ordureau; Maria Körner; Joao A. Paulo; J. Wade Harper

    Mammalian cells reorganize their proteomes in response to nutrient stress through translational suppression and degradative mechanisms using the proteasome and autophagy systems1,2. Ribosomes are central targets of this response, as they are responsible for translation and subject to lysosomal turnover during nutrient stress3,4,5. The abundance of ribosomal (r)-proteins (around 6% of the proteome;

    更新日期:2020-07-01
  • Physiological blood–brain transport is impaired with age by a shift in transcytosis
    Nature (IF 42.778) Pub Date : 2020-07-01
    Andrew C. Yang; Marc Y. Stevens; Michelle B. Chen; Davis P. Lee; Daniel Stähli; David Gate; Kévin Contrepois; Winnie Chen; Tal Iram; Lichao Zhang; Ryan T. Vest; Aisling Chaney; Benoit Lehallier; Niclas Olsson; Haley du Bois; Ryan Hsieh; Haley C. Cropper; Daniela Berdnik; Lulin Li; Elizabeth Y. Wang; Gavin M. Traber; Carolyn R. Bertozzi; Jian Luo; Michael P. Snyder; Joshua E. Elias; Stephen R. Quake;

    The vascular interface of the brain, known as the blood–brain barrier (BBB), is understood to maintain brain function in part via its low transcellular permeability1,2,3. Yet, recent studies have demonstrated that brain ageing is sensitive to circulatory proteins4,5. Thus, it is unclear whether permeability to individually injected exogenous tracers—as is standard in BBB studies—fully represents blood-to-brain

    更新日期:2020-07-01
  • A substrate-specific mTORC1 pathway underlies Birt–Hogg–Dubé syndrome
    Nature (IF 42.778) Pub Date : 2020-07-01
    Gennaro Napolitano; Chiara Di Malta; Alessandra Esposito; Mariana E. G. de Araujo; Salvatore Pece; Giovanni Bertalot; Maria Matarese; Valerio Benedetti; Angela Zampelli; Taras Stasyk; Diletta Siciliano; Alessandro Venuta; Marcella Cesana; Claudia Vilardo; Edoardo Nusco; Jlenia Monfregola; Alessia Calcagnì; Pier Paolo Di Fiore; Lukas A. Huber; Andrea Ballabio

    The mechanistic target of rapamycin complex 1 (mTORC1) is a key metabolic hub that controls the cellular response to environmental cues by exerting its kinase activity on multiple substrates1,2,3. However, whether mTORC1 responds to diverse stimuli by differentially phosphorylating specific substrates is poorly understood. Here we show that transcription factor EB (TFEB), a master regulator of lysosomal

    更新日期:2020-07-01
  • Structure and flexibility in cortical representations of odour space
    Nature (IF 42.778) Pub Date : 2020-07-01
    Stan L. Pashkovski; Giuliano Iurilli; David Brann; Daniel Chicharro; Kristen Drummey; Kevin Franks; Stefano Panzeri; Sandeep Robert Datta

    The cortex organizes sensory information to enable discrimination and generalization1,2,3,4. As systematic representations of chemical odour space have not yet been described in the olfactory cortex, it remains unclear how odour relationships are encoded to place chemically distinct but similar odours, such as lemon and orange, into perceptual categories, such as citrus5,6,7. Here, by combining chemoinformatics

    更新日期:2020-07-01
  • Quantum correlations between light and the kilogram-mass mirrors of LIGO
    Nature (IF 42.778) Pub Date : 2020-07-01
    Haocun Yu; L. McCuller; M. Tse; N. Kijbunchoo; L. Barsotti; N. Mavalvala

    The measurement of minuscule forces and displacements with ever greater precision is inhibited by the Heisenberg uncertainty principle, which imposes a limit to the precision with which the position of an object can be measured continuously, known as the standard quantum limit1,2,3,4. When light is used as the probe, the standard quantum limit arises from the balance between the uncertainties of the

    更新日期:2020-07-01
  • Cryo-EM of elongating ribosome with EF-Tu•GTP elucidates tRNA proofreading
    Nature (IF 42.778) Pub Date : 2020-07-01
    Anna B. Loveland; Gabriel Demo; Andrei A. Korostelev

    Ribosomes accurately decode mRNA by proofreading each aminoacyl-tRNA that is delivered by the elongation factor EF-Tu1. To understand the molecular mechanism of this proofreading step it is necessary to visualize GTP-catalysed elongation, which has remained a challenge2,3,4. Here we use time-resolved cryogenic electron microscopy to reveal 33 ribosomal states after the delivery of aminoacyl-tRNA by

    更新日期:2020-07-01
  • Wapl repression by Pax5 promotes V gene recombination by Igh loop extrusion
    Nature (IF 42.778) Pub Date : 2020-07-01
    Louisa Hill; Anja Ebert; Markus Jaritz; Gordana Wutz; Kota Nagasaka; Hiromi Tagoh; Daniela Kostanova-Poliakova; Karina Schindler; Qiong Sun; Peter Bönelt; Maria Fischer; Jan-Michael Peters; Meinrad Busslinger

    Nuclear processes, such as V(D)J recombination, are orchestrated by the three-dimensional organization of chromosomes at multiple levels, including compartments1 and topologically associated domains (TADs)2,3 consisting of chromatin loops4. TADs are formed by chromatin-loop extrusion5,6,7, which depends on the loop-extrusion function of the ring-shaped cohesin complex8,9,10,11,12. Conversely, the cohesin-release

    更新日期:2020-07-01
  • Suppression of a SARS-CoV-2 outbreak in the Italian municipality of Vo’
    Nature (IF 42.778) Pub Date : 2020-06-30
    Enrico Lavezzo; Elisa Franchin; Constanze Ciavarella; Gina Cuomo-Dannenburg; Luisa Barzon; Claudia Del Vecchio; Lucia Rossi; Riccardo Manganelli; Arianna Loregian; Nicolò Navarin; Davide Abate; Manuela Sciro; Stefano Merigliano; Ettore De Canale; Maria Cristina Vanuzzo; Valeria Besutti; Francesca Saluzzo; Francesco Onelia; Monia Pacenti; Saverio Parisi; Giovanni Carretta; Daniele Donato; Luciano Flor;

    On the 21st of February 2020 a resident of the municipality of Vo’, a small town near Padua, died of pneumonia due to SARS-CoV-2 infection1. This was the first COVID-19 death detected in Italy since the emergence of SARS-CoV-2 in the Chinese city of Wuhan, Hubei province2. In response, the regional authorities imposed the lockdown of the whole municipality for 14 days3. We collected information on

    更新日期:2020-06-30
  • Structures of metabotropic GABA B receptor
    Nature (IF 42.778) Pub Date : 2020-06-24
    Makaía M. Papasergi-Scott; Michael J. Robertson; Alpay B. Seven; Ouliana Panova; Jesper M. Mathiesen; Georgios Skiniotis

    GABA (γ-aminobutyric acid) stimulation of the metabotropic GABAB receptor results in prolonged inhibition of neurotransmission that is central to brain physiology1. GABAB belongs to the Family C of G protein-coupled receptors (GPCRs), which operate as dimers to relay synaptic neurotransmitter signals into a cellular response through the binding and activation of heterotrimeric G proteins2,3. GABAB

    更新日期:2020-06-24
  • Structure of human GABA B receptor in an inactive state
    Nature (IF 42.778) Pub Date : 2020-06-24
    Jinseo Park; Ziao Fu; Aurel Frangaj; Jonathan Liu; Lidia Mosyak; Tong Shen; Vesna N. Slavkovich; Kimberly M. Ray; Jaume Taura; Baohua Cao; Yong Geng; Hao Zuo; Yongjun Kou; Robert Grassucci; Shaoxia Chen; Zheng Liu; Xin Lin; Justin P. Williams; William J. Rice; Edward T. Eng; Rick K. Huang; Rajesh K. Soni; Brian Kloss; Zhiheng Yu; Jonathan A. Javitch; Wayne A. Hendrickson; Paul A. Slesinger; Matthias

    The human GABAB receptor—a member of the class C family of G-protein-coupled receptors (GPCRs)—mediates inhibitory neurotransmission and has been implicated in epilepsy, pain and addiction1. A unique GPCR that is known to require heterodimerization for function2,3,4,5,6, the GABAB receptor has two subunits, GABAB1 and GABAB2, that are structurally homologous but perform distinct and complementary functions

    更新日期:2020-06-24
  • Mapping the emergence of molecular vibrations mediating bond formation
    Nature (IF 42.778) Pub Date : 2020-06-24
    Jong Goo Kim; Shunsuke Nozawa; Hanui Kim; Eun Hyuk Choi; Tokushi Sato; Tae Wu Kim; Kyung Hwan Kim; Hosung Ki; Jungmin Kim; Minseo Choi; Yunbeom Lee; Jun Heo; Key Young Oang; Kouhei Ichiyanagi; Ryo Fukaya; Jae Hyuk Lee; Jaeku Park; Intae Eom; Sae Hwan Chun; Sunam Kim; Minseok Kim; Tetsuo Katayama; Tadashi Togashi; Sigeki Owada; Makina Yabashi; Sang Jin Lee; Seonggon Lee; Chi Woo Ahn; Doo-Sik Ahn; Jiwon

    Fundamental studies of chemical reactions often consider the molecular dynamics along a reaction coordinate using a calculated or suggested potential energy surface1,2,3,4,5. But fully mapping such dynamics experimentally, by following all nuclear motions in a time-resolved manner—that is, the motions of wavepackets—is challenging and has not yet been realized even for the simple stereotypical bimolecular

    更新日期:2020-06-24
  • FLT3 stop mutation increases FLT3 ligand level and risk of autoimmune thyroid disease
    Nature (IF 42.778) Pub Date : 2020-06-24
    Saedis Saevarsdottir; Thorunn A. Olafsdottir; Erna V. Ivarsdottir; Gisli H. Halldorsson; Kristbjorg Gunnarsdottir; Asgeir Sigurdsson; Ari Johannesson; Jon K. Sigurdsson; Thorhildur Juliusdottir; Sigrun H. Lund; Asgeir O. Arnthorsson; Edda L. Styrmisdottir; Julius Gudmundsson; Gerdur M. Grondal; Kristjan Steinsson; Lars Alfredsson; Johan Askling; Rafn Benediktsson; Ragnar Bjarnason; Arni J. Geirsson;

    Autoimmune thyroid disease is the most common autoimmune disease and is highly heritable1. Here, by using a genome-wide association study of 30,234 cases and 725,172 controls from Iceland and the UK Biobank, we find 99 sequence variants at 93 loci, of which 84 variants are previously unreported2,3,4,5,6,7. A low-frequency (1.36%) intronic variant in FLT3 (rs76428106-C) has the largest effect on risk

    更新日期:2020-06-24
  • Reversing a model of Parkinson’s disease with in situ converted nigral neurons
    Nature (IF 42.778) Pub Date : 2020-06-24
    Hao Qian; Xinjiang Kang; Jing Hu; Dongyang Zhang; Zhengyu Liang; Fan Meng; Xuan Zhang; Yuanchao Xue; Roy Maimon; Steven F. Dowdy; Neal K. Devaraj; Zhuan Zhou; William C. Mobley; Don W. Cleveland; Xiang-Dong Fu

    Parkinson’s disease is characterized by loss of dopamine neurons in the substantia nigra1. Similar to other major neurodegenerative disorders, there are no disease-modifying treatments for Parkinson’s disease. While most treatment strategies aim to prevent neuronal loss or protect vulnerable neuronal circuits, a potential alternative is to replace lost neurons to reconstruct disrupted circuits2. Here

    更新日期:2020-06-24
  • Whole-genome sequencing of patients with rare diseases in a national health system
    Nature (IF 42.778) Pub Date : 2020-06-24
    Ernest Turro; William J. Astle; Karyn Megy; Stefan Gräf; Daniel Greene; Olga Shamardina; Hana Lango Allen; Alba Sanchis-Juan; Mattia Frontini; Chantal Thys; Jonathan Stephens; Rutendo Mapeta; Oliver S. Burren; Kate Downes; Matthias Haimel; Salih Tuna; Sri V. V. Deevi; Timothy J. Aitman; David L. Bennett; Paul Calleja; Keren Carss; Mark J. Caulfield; Patrick F. Chinnery; Peter H. Dixon; Daniel P. Gale;

    Most patients with rare diseases do not receive a molecular diagnosis and the aetiological variants and causative genes for more than half such disorders remain to be discovered1. Here we used whole-genome sequencing (WGS) in a national health system to streamline diagnosis and to discover unknown aetiological variants in the coding and non-coding regions of the genome. We generated WGS data for 13

    更新日期:2020-06-24
  • IL-18BP is a secreted immune checkpoint and barrier to IL-18 immunotherapy
    Nature (IF 42.778) Pub Date : 2020-06-24
    Ting Zhou; William Damsky; Orr-El Weizman; Meaghan K. McGeary; K. Patricia Hartmann; Connor E. Rosen; Suzanne Fischer; Ruaidhri Jackson; Richard A. Flavell; Jun Wang; Miguel F. Sanmamed; Marcus W. Bosenberg; Aaron M. Ring

    Cytokines were the first modern immunotherapies to produce durable responses in patients with advanced cancer, but they have only modest efficacy and limited tolerability1,2. In an effort to identify alternative cytokine pathways for immunotherapy, we found that components of the interleukin-18 (IL-18) pathway are upregulated on tumour-infiltrating lymphocytes, suggesting that IL-18 therapy could enhance

    更新日期:2020-06-24
  • DNA surface exploration and operator bypassing during target search
    Nature (IF 42.778) Pub Date : 2020-06-24
    Emil Marklund; Brad van Oosten; Guanzhong Mao; Elias Amselem; Kalle Kipper; Anton Sabantsev; Andrew Emmerich; Daniel Globisch; Xuan Zheng; Laura C. Lehmann; Otto G. Berg; Magnus Johansson; Johan Elf; Sebastian Deindl

    Many proteins that bind specific DNA sequences search the genome by combining three-dimensional diffusion with one-dimensional sliding on nonspecific DNA1,2,3,4,5. Here we combine resonance energy transfer and fluorescence correlation measurements to characterize how individual lac repressor (LacI) molecules explore the DNA surface during the one-dimensional phase of target search. To track the rotation

    更新日期:2020-06-24
  • Single-molecule imaging of transcription dynamics in somatic stem cells
    Nature (IF 42.778) Pub Date : 2020-06-24
    Justin C. Wheat; Yehonatan Sella; Michael Willcockson; Arthur I. Skoultchi; Aviv Bergman; Robert H. Singer; Ulrich Steidl

    Molecular noise is a natural phenomenon that is inherent to all biological systems1,2. How stochastic processes give rise to the robust outcomes that support tissue homeostasis remains unclear. Here we use single-molecule RNA fluorescent in situ hybridization (smFISH) on mouse stem cells derived from haematopoietic tissue to measure the transcription dynamics of three key genes that encode transcription

    更新日期:2020-06-24
  • High-strength Damascus steel by additive manufacturing
    Nature (IF 42.778) Pub Date : 2020-06-24
    Philipp Kürnsteiner; Markus Benjamin Wilms; Andreas Weisheit; Baptiste Gault; Eric Aimé Jägle; Dierk Raabe

    Laser additive manufacturing is attractive for the production of complex, three-dimensional parts from metallic powder using a computer-aided design model1,2,3. The approach enables the digital control of the processing parameters and thus the resulting alloy’s microstructure, for example, by using high cooling rates and cyclic re-heating4,5,6,7,8,9,10. We recently showed that this cyclic re-heating

    更新日期:2020-06-24
  • A planet within the debris disk around the pre-main-sequence star AU Microscopii
    Nature (IF 42.778) Pub Date : 2020-06-24
    Peter Plavchan; Thomas Barclay; Jonathan Gagné; Peter Gao; Bryson Cale; William Matzko; Diana Dragomir; Sam Quinn; Dax Feliz; Keivan Stassun; Ian J. M. Crossfield; David A. Berardo; David W. Latham; Ben Tieu; Guillem Anglada-Escudé; George Ricker; Roland Vanderspek; Sara Seager; Joshua N. Winn; Jon M. Jenkins; Stephen Rinehart; Akshata Krishnamurthy; Scott Dynes; John Doty; Fred Adams; Dennis A. Afanasev;

    AU Microscopii (AU Mic) is the second closest pre-main-sequence star, at a distance of 9.79 parsecs and with an age of 22 million years1. AU Mic possesses a relatively rare2 and spatially resolved3 edge-on debris disk extending from about 35 to 210 astronomical units from the star4, and with clumps exhibiting non-Keplerian motion5,6,7. Detection of newly formed planets around such a star is challenged

    更新日期:2020-06-24
  • Intracellular pH controls WNT downstream of glycolysis in amniote embryos
    Nature (IF 42.778) Pub Date : 2020-06-24
    Masayuki Oginuma; Yukiko Harima; Oscar A. Tarazona; Margarete Diaz-Cuadros; Arthur Michaut; Tohru Ishitani; Fengzhu Xiong; Olivier Pourquié

    Formation of the body of vertebrate embryos proceeds sequentially by posterior addition of tissues from the tail bud. Cells of the tail bud and the posterior presomitic mesoderm, which control posterior elongation1, exhibit a high level of aerobic glycolysis that is reminiscent of the metabolic status of cancer cells experiencing the Warburg effect2,3. Glycolytic activity downstream of fibroblast growth

    更新日期:2020-06-24
  • Pervasive lesion segregation shapes cancer genome evolution
    Nature (IF 42.778) Pub Date : 2020-06-24
    Sarah J. Aitken; Craig J. Anderson; Frances Connor; Oriol Pich; Vasavi Sundaram; Christine Feig; Tim F. Rayner; Margus Lukk; Stuart Aitken; Juliet Luft; Elissavet Kentepozidou; Claudia Arnedo-Pac; Sjoerd V. Beentjes; Susan E. Davies; Ruben M. Drews; Ailith Ewing; Vera B. Kaiser; Ava Khamseh; Erika López-Arribillaga; Aisling M. Redmond; Javier Santoyo-Lopez; Inés Sentís; Lana Talmane; Andrew D. Yates;

    Cancers arise through the acquisition of oncogenic mutations and grow by clonal expansion1,2. Here we reveal that most mutagenic DNA lesions are not resolved into a mutated DNA base pair within a single cell cycle. Instead, DNA lesions segregate, unrepaired, into daughter cells for multiple cell generations, resulting in the chromosome-scale phasing of subsequent mutations. We characterize this process

    更新日期:2020-06-24
  • Optical Fourier surfaces
    Nature (IF 42.778) Pub Date : 2020-06-24
    Nolan Lassaline; Raphael Brechbühler; Sander J. W. Vonk; Korneel Ridderbeek; Martin Spieser; Samuel Bisig; Boris le Feber; Freddy T. Rabouw; David J. Norris

    Gratings1 and holograms2 use patterned surfaces to tailor optical signals by diffraction. Despite their long history, variants with remarkable functionalities continue to be developed3,4. Further advances could exploit Fourier optics5, which specifies the surface pattern that generates a desired diffracted output through its Fourier transform. To shape the optical wavefront, the ideal surface profile

    更新日期:2020-06-24
  • Monogenic and polygenic inheritance become instruments for clonal selection
    Nature (IF 42.778) Pub Date : 2020-06-24
    Po-Ru Loh; Giulio Genovese; Steven A. McCarroll

    Clonally expanded blood cells that contain somatic mutations (clonal haematopoiesis) are commonly acquired with age and increase the risk of blood cancer1,2,3,4,5,6,7,8,9. The blood clones identified so far contain diverse large-scale mosaic chromosomal alterations (deletions, duplications and copy-neutral loss of heterozygosity (CN-LOH)) on all chromosomes1,2,5,6,9, but the sources of selective advantage

    更新日期:2020-06-24
  • Variable water input controls evolution of the Lesser Antilles volcanic arc
    Nature (IF 42.778) Pub Date : 2020-06-24
    George F. Cooper; Colin G. Macpherson; Jon D. Blundy; Benjamin Maunder; Robert W. Allen; Saskia Goes; Jenny S Collier; Lidong Bie; Nicholas Harmon; Stephen P. Hicks; Alexander A. Iveson; Julie Prytulak; Andreas Rietbrock; Catherine A. Rychert; Jon P. Davidson

    Oceanic lithosphere carries volatiles, notably water, into the mantle through subduction at convergent plate boundaries. This subducted water exercises control on the production of magma, earthquakes, formation of continental crust and mineral resources. Identifying different potential fluid sources (sediments, crust and mantle lithosphere) and tracing fluids from their release to the surface has proved

    更新日期:2020-06-24
  • Chromosomal alterations among age-related haematopoietic clones in Japan
    Nature (IF 42.778) Pub Date : 2020-06-24
    Chikashi Terao; Akari Suzuki; Yukihide Momozawa; Masato Akiyama; Kazuyoshi Ishigaki; Kazuhiko Yamamoto; Koichi Matsuda; Yoshinori Murakami; Steven A. McCarroll; Michiaki Kubo; Po-Ru Loh; Yoichiro Kamatani

    The extent to which the biology of oncogenesis and ageing are shaped by factors that distinguish human populations is unknown. Haematopoietic clones with acquired mutations become common with advancing age and can lead to blood cancers1,2,3,4,5,6,7,8,9,10. Here we describe shared and population-specific patterns of genomic mutations and clonal selection in haematopoietic cells on the basis of 33,250 autosomal

    更新日期:2020-06-24
  • Ultralow-dielectric-constant amorphous boron nitride
    Nature (IF 42.778) Pub Date : 2020-06-24
    Seokmo Hong; Chang-Seok Lee; Min-Hyun Lee; Yeongdong Lee; Kyung Yeol Ma; Gwangwoo Kim; Seong In Yoon; Kyuwook Ihm; Ki-Jeong Kim; Tae Joo Shin; Sang Won Kim; Eun-chae Jeon; Hansol Jeon; Ju-Young Kim; Hyung-Ik Lee; Zonghoon Lee; Aleandro Antidormi; Stephan Roche; Manish Chhowalla; Hyeon-Jin Shin; Hyeon Suk Shin

    Decrease in processing speed due to increased resistance and capacitance delay is a major obstacle for the down-scaling of electronics1,2,3. Minimizing the dimensions of interconnects (metal wires that connect different electronic components on a chip) is crucial for the miniaturization of devices. Interconnects are isolated from each other by non-conducting (dielectric) layers. So far, research has

    更新日期:2020-06-24
  • Fluorescent bicolour sensor for low-background neutrinoless double β decay experiments.
    Nature (IF 42.778) Pub Date : 2020-06-22
    Iván Rivilla,Borja Aparicio,Juan M Bueno,David Casanova,Claire Tonnelé,Zoraida Freixa,Pablo Herrero,Celia Rogero,José I Miranda,Rosa M Martínez-Ojeda,Francesc Monrabal,Beñat Olave,Thomas Schäfer,Pablo Artal,David Nygren,Fernando P Cossío,Juan J Gómez-Cadenas

    Observation of the neutrinoless double β decay is the only practical way to establish that neutrinos are their own antiparticles1. Because of the small masses of neutrinos, the lifetime of neutrinoless double β decay is expected to be at least ten orders of magnitude greater than the typical lifetimes of natural radioactive chains, which can mimic the experimental signature of neutrinoless double β

    更新日期:2020-06-22
  • Convergent antibody responses to SARS-CoV-2 in convalescent individuals.
    Nature (IF 42.778) Pub Date : 2020-06-18
    Davide F Robbiani,Christian Gaebler,Frauke Muecksch,Julio C C Lorenzi,Zijun Wang,Alice Cho,Marianna Agudelo,Christopher O Barnes,Anna Gazumyan,Shlomo Finkin,Thomas Hägglöf,Thiago Y Oliveira,Charlotte Viant,Arlene Hurley,Hans-Heinrich Hoffmann,Katrina G Millard,Rhonda G Kost,Melissa Cipolla,Kristie Gordon,Filippo Bianchini,Spencer T Chen,Victor Ramos,Roshni Patel,Juan Dizon,Irina Shimeliovich,Pilar

    During the COVID-19 pandemic, SARS-CoV-2 infected millions of people and claimed hundreds of thousands of lives. Virus entry into cells depends on the receptor binding domain (RBD) of the SARS-CoV-2 spike protein (S). Although there is no vaccine, it is likely that antibodies will be essential for protection. However, little is known about the human antibody response to SARS-CoV-21–5. Here we report

    更新日期:2020-06-18
  • Integrated turnkey soliton microcombs.
    Nature (IF 42.778) Pub Date : 2020-06-17
    Boqiang Shen,Lin Chang,Junqiu Liu,Heming Wang,Qi-Fan Yang,Chao Xiang,Rui Ning Wang,Jijun He,Tianyi Liu,Weiqiang Xie,Joel Guo,David Kinghorn,Lue Wu,Qing-Xin Ji,Tobias J Kippenberg,Kerry Vahala,John E Bowers

    Optical frequency combs have a wide range of applications in science and technology1. An important development for miniature and integrated comb systems is the formation of dissipative Kerr solitons in coherently pumped high-quality-factor optical microresonators2,3,4,5,6,7,8,9. Such soliton microcombs10 have been applied to spectroscopy11,12,13, the search for exoplanets14,15, optical frequency synthesis16

    更新日期:2020-06-17
  • The first dinosaur egg was soft.
    Nature (IF 42.778) Pub Date : 2020-06-17
    Mark A Norell,Jasmina Wiemann,Matteo Fabbri,Congyu Yu,Claudia A Marsicano,Anita Moore-Nall,David J Varricchio,Diego Pol,Darla K Zelenitsky

    Calcified eggshells protect developing embryos against environmental stress and contribute to reproductive success1. As modern crocodilians and birds lay hard-shelled eggs, this eggshell type has been inferred for non-avian dinosaurs. Known dinosaur eggshells are characterized by an innermost membrane, an overlying protein matrix containing calcite, and an outermost waxy cuticle2,3,4,5,6,7. The calcitic

    更新日期:2020-06-17
  • Imaging single glycans.
    Nature (IF 42.778) Pub Date : 2020-06-17
    X Wu,M Delbianco,K Anggara,T Michnowicz,A Pardo-Vargas,P Bharate,S Sen,M Pristl,S Rauschenbach,U Schlickum,S Abb,P H Seeberger,K Kern

    Imaging of biomolecules guides our understanding of their diverse structures and functions1,2. Real-space imaging at sub-nanometre resolution using cryo-electron microscopy has provided key insights into proteins and their assemblies3,4. Direct molecular imaging of glycans—the predominant biopolymers on Earth, with a plethora of structural and biological functions5—has not been possible so far6. The

    更新日期:2020-06-17
  • A dynastic elite in monumental Neolithic society.
    Nature (IF 42.778) Pub Date : 2020-06-17
    Lara M Cassidy,Ros Ó Maoldúin,Thomas Kador,Ann Lynch,Carleton Jones,Peter C Woodman,Eileen Murphy,Greer Ramsey,Marion Dowd,Alice Noonan,Ciarán Campbell,Eppie R Jones,Valeria Mattiangeli,Daniel G Bradley

    The nature and distribution of political power in Europe during the Neolithic era remains poorly understood1. During this period, many societies began to invest heavily in building monuments, which suggests an increase in social organization. The scale and sophistication of megalithic architecture along the Atlantic seaboard, culminating in the great passage tomb complexes, is particularly impressive2

    更新日期:2020-06-17
  • Emergent constraint on Arctic Ocean acidification in the twenty-first century.
    Nature (IF 42.778) Pub Date : 2020-06-17
    Jens Terhaar,Lester Kwiatkowski,Laurent Bopp

    The ongoing uptake of anthropogenic carbon by the ocean leads to ocean acidification, a process that results in a reduction in pH and in the saturation state of biogenic calcium carbonate minerals aragonite (Ωarag) and calcite (Ωcalc)1,2. Because of its naturally low Ωarag and Ωcalc (refs. 2,3), the Arctic Ocean is considered the region most susceptible to future acidification and associated ecosystem

    更新日期:2020-06-17
  • Hidden neural states underlie canary song syntax.
    Nature (IF 42.778) Pub Date : 2020-06-17
    Yarden Cohen,Jun Shen,Dawit Semu,Daniel P Leman,William A Liberti,L Nathan Perkins,Derek C Liberti,Darrell N Kotton,Timothy J Gardner

    Coordinated skills such as speech or dance involve sequences of actions that follow syntactic rules in which transitions between elements depend on the identities and order of past actions. Canary songs consist of repeated syllables called phrases, and the ordering of these phrases follows long-range rules1 in which the choice of what to sing depends on the song structure many seconds prior. The neural

    更新日期:2020-06-17
  • Lineage dynamics of the endosymbiotic cell type in the soft coral Xenia.
    Nature (IF 42.778) Pub Date : 2020-06-17
    Minjie Hu,Xiaobin Zheng,Chen-Ming Fan,Yixian Zheng

    Many corals harbour symbiotic dinoflagellate algae. The algae live inside coral cells in a specialized membrane compartment known as the symbiosome, which shares the photosynthetically fixed carbon with coral host cells while host cells provide inorganic carbon to the algae for photosynthesis1. This endosymbiosis—which is critical for the maintenance of coral reef ecosystems—is increasingly threatened

    更新日期:2020-06-17
  • Structural basis of the activation of a metabotropic GABA receptor.
    Nature (IF 42.778) Pub Date : 2020-06-17
    Hamidreza Shaye,Andrii Ishchenko,Jordy Homing Lam,Gye Won Han,Li Xue,Philippe Rondard,Jean-Philippe Pin,Vsevolod Katritch,Cornelius Gati,Vadim Cherezov

    Metabotropic γ-aminobutyric acid receptors (GABAB) are involved in the modulation of synaptic responses in the central nervous system and have been implicated in neuropsychological conditions that range from addiction to psychosis1. GABAB belongs to class C of the G-protein-coupled receptors, and its functional entity comprises an obligate heterodimer that is composed of the GB1 and GB2 subunits2.

    更新日期:2020-06-17
  • A neurotransmitter produced by gut bacteria modulates host sensory behaviour.
    Nature (IF 42.778) Pub Date : 2020-06-17
    Michael P O'Donnell,Bennett W Fox,Pin-Hao Chao,Frank C Schroeder,Piali Sengupta

    Animals coexist in commensal, pathogenic or mutualistic relationships with complex communities of diverse organisms, including microorganisms1. Some bacteria produce bioactive neurotransmitters that have previously been proposed to modulate nervous system activity and behaviours of their hosts2,3. However, the mechanistic basis of this microbiota–brain signalling and its physiological relevance are

    更新日期:2020-06-17
  • Resolving acceleration to very high energies along the jet of Centaurus A.
    Nature (IF 42.778) Pub Date : 2020-06-17

    The nearby radio galaxy Centaurus A belongs to a class of active galaxies that are luminous at radio wavelengths. Most show collimated relativistic outflows known as jets, which extend over hundreds of thousands of parsecs for the most powerful sources. Accretion of matter onto the central supermassive black hole is believed to fuel these jets and power their emission1. Synchrotron radiation from relativistic

    更新日期:2020-06-17
  • Senolytic CAR T cells reverse senescence-associated pathologies.
    Nature (IF 42.778) Pub Date : 2020-06-17
    Corina Amor,Judith Feucht,Josef Leibold,Yu-Jui Ho,Changyu Zhu,Direna Alonso-Curbelo,Jorge Mansilla-Soto,Jacob A Boyer,Xiang Li,Theodoros Giavridis,Amanda Kulick,Shauna Houlihan,Ellinor Peerschke,Scott L Friedman,Vladimir Ponomarev,Alessandra Piersigilli,Michel Sadelain,Scott W Lowe

    Cellular senescence is characterized by stable cell-cycle arrest and a secretory program that modulates the tissue microenvironment1,2. Physiologically, senescence serves as a tumour-suppressive mechanism that prevents the expansion of premalignant cells3,4 and has a beneficial role in wound-healing responses5,6. Pathologically, the aberrant accumulation of senescent cells generates an inflammatory

    更新日期:2020-06-17
  • The proteome landscape of the kingdoms of life.
    Nature (IF 42.778) Pub Date : 2020-06-17
    Johannes B Müller,Philipp E Geyer,Ana R Colaço,Peter V Treit,Maximilian T Strauss,Mario Oroshi,Sophia Doll,Sebastian Virreira Winter,Jakob M Bader,Niklas Köhler,Fabian Theis,Alberto Santos,Matthias Mann

    Proteins carry out the vast majority of functions in all biological domains, but for technological reasons their large-scale investigation has lagged behind the study of genomes. Since the first essentially complete eukaryotic proteome was reported1, advances in mass-spectrometry-based proteomics2 have enabled increasingly comprehensive identification and quantification of the human proteome3,4,5,6

    更新日期:2020-06-17
  • Hierarchically structured diamond composite with exceptional toughness.
    Nature (IF 42.778) Pub Date : 2020-06-17
    Yonghai Yue,Yufei Gao,Wentao Hu,Bo Xu,Jing Wang,Xuejiao Zhang,Qi Zhang,Yanbin Wang,Binghui Ge,Zhenyu Yang,Zihe Li,Pan Ying,Xiaoxiao Liu,Dongli Yu,Bin Wei,Zhongchang Wang,Xiang-Feng Zhou,Lin Guo,Yongjun Tian

    The well known trade-off between hardness and toughness (resistance to fracture) makes simultaneous improvement of both properties challenging, especially in diamond. The hardness of diamond can be increased through nanostructuring strategies1,2, among which the formation of high-density nanoscale twins — crystalline regions related by symmetry — also toughens diamond2. In materials other than diamond

    更新日期:2020-06-17
  • Periodic activity from a fast radio burst source.
    Nature (IF 42.778) Pub Date : 2020-06-17

    Fast radio bursts (FRBs) are bright, millisecond-duration radio transients originating from sources at extragalactic distances1, the origin of which is unknown. Some FRB sources emit repeat bursts, ruling out cataclysmic origins for those events2,3,4. Despite searches for periodicity in repeat burst arrival times on timescales from milliseconds to many days2,5,6,7, these bursts have hitherto been observed

    更新日期:2020-06-17
  • Dynamic RNA acetylation revealed by quantitative cross-evolutionary mapping.
    Nature (IF 42.778) Pub Date : 2020-06-17
    Aldema Sas-Chen,Justin M Thomas,Donna Matzov,Masato Taoka,Kellie D Nance,Ronit Nir,Keri M Bryson,Ran Shachar,Geraldy L S Liman,Brett W Burkhart,Supuni Thalalla Gamage,Yuko Nobe,Chloe A Briney,Michaella J Levy,Ryan T Fuchs,G Brett Robb,Jesse Hartmann,Sunny Sharma,Qishan Lin,Laurence Florens,Michael P Washburn,Toshiaki Isobe,Thomas J Santangelo,Moran Shalev-Benami,Jordan L Meier,Schraga Schwartz

    N4-acetylcytidine (ac4C) is an ancient and highly conserved RNA modification that is present on tRNA and rRNA and has recently been investigated in eukaryotic mRNA1,2,3. However, the distribution, dynamics and functions of cytidine acetylation have yet to be fully elucidated. Here we report ac4C-seq, a chemical genomic method for the transcriptome-wide quantitative mapping of ac4C at single-nucleotide

    更新日期:2020-06-17
  • Frequency combs induced by phase turbulence.
    Nature (IF 42.778) Pub Date : 2020-06-17
    Marco Piccardo,Benedikt Schwarz,Dmitry Kazakov,Maximilian Beiser,Nikola Opačak,Yongrui Wang,Shantanu Jha,Johannes Hillbrand,Michele Tamagnone,Wei Ting Chen,Alexander Y Zhu,Lorenzo L Columbo,Alexey Belyanin,Federico Capasso

    Wave instability—the process that gives rise to turbulence in hydrodynamics1—represents the mechanism by which a small disturbance in a wave grows in amplitude owing to nonlinear interactions. In photonics, wave instabilities result in modulated light waveforms that can become periodic in the presence of coherent locking mechanisms. These periodic optical waveforms are known as optical frequency combs2

    更新日期:2020-06-17
  • A giant soft-shelled egg from the Late Cretaceous of Antarctica.
    Nature (IF 42.778) Pub Date : 2020-06-17
    Lucas J Legendre,David Rubilar-Rogers,Grace M Musser,Sarah N Davis,Rodrigo A Otero,Alexander O Vargas,Julia A Clarke

    Egg size and structure reflect important constraints on the reproductive and life-history characteristics of vertebrates1. More than two-thirds of all extant amniotes lay eggs2. During the Mesozoic era (around 250 million to 65 million years ago), body sizes reached extremes; nevertheless, the largest known egg belongs to the only recently extinct elephant bird3, which was roughly 66 million years

    更新日期:2020-06-17
  • A metabolic pathway for bile acid dehydroxylation by the gut microbiome.
    Nature (IF 42.778) Pub Date : 2020-06-17
    Masanori Funabashi,Tyler L Grove,Min Wang,Yug Varma,Molly E McFadden,Laura C Brown,Chunjun Guo,Steven Higginbottom,Steven C Almo,Michael A Fischbach

    The gut microbiota synthesize hundreds of molecules, many of which influence host physiology. Among the most abundant metabolites are the secondary bile acids deoxycholic acid (DCA) and lithocholic acid (LCA), which accumulate at concentrations of around 500 μM and are known to block the growth of Clostridium difficile1, promote hepatocellular carcinoma2 and modulate host metabolism via the G-protein-coupled

    更新日期:2020-06-17
  • Molecular basis of β-arrestin coupling to formoterol-bound β1-adrenoceptor.
    Nature (IF 42.778) Pub Date : 2020-06-17
    Yang Lee,Tony Warne,Rony Nehmé,Shubhi Pandey,Hemlata Dwivedi-Agnihotri,Madhu Chaturvedi,Patricia C Edwards,Javier García-Nafría,Andrew G W Leslie,Arun K Shukla,Christopher G Tate

    The β1-adrenoceptor (β1AR) is a G-protein-coupled receptor (GPCR) that couples1 to the heterotrimeric G protein Gs. G-protein-mediated signalling is terminated by phosphorylation of the C terminus of the receptor by GPCR kinases (GRKs) and by coupling of β-arrestin 1 (βarr1, also known as arrestin 2), which displaces Gs and induces signalling through the MAP kinase pathway2. The ability of synthetic

    更新日期:2020-06-17
  • Entanglement-based secure quantum cryptography over 1,120 kilometres.
    Nature (IF 42.778) Pub Date : 2020-06-15
    Juan Yin,Yu-Huai Li,Sheng-Kai Liao,Meng Yang,Yuan Cao,Liang Zhang,Ji-Gang Ren,Wen-Qi Cai,Wei-Yue Liu,Shuang-Lin Li,Rong Shu,Yong-Mei Huang,Lei Deng,Li Li,Qiang Zhang,Nai-Le Liu,Yu-Ao Chen,Chao-Yang Lu,Xiang-Bin Wang,Feihu Xu,Jian-Yu Wang,Cheng-Zhi Peng,Artur K Ekert,Jian-Wei Pan

    Quantum key distribution (QKD)1,2,3 is a theoretically secure way of sharing secret keys between remote users. It has been demonstrated in a laboratory over a coiled optical fibre up to 404 kilometres long4,5,6,7. In the field, point-to-point QKD has been achieved from a satellite to a ground station up to 1,200 kilometres away8,9,10. However, real-world QKD-based cryptography targets physically separated

    更新日期:2020-06-15
  • Leveraging excited-state coherence for synthetic control of ultrafast dynamics.
    Nature (IF 42.778) Pub Date : 2020-06-11
    Bryan C Paulus,Sara L Adelman,Lindsey L Jamula,James K McCusker

    Design-specific control over excited-state dynamics is necessary for any application seeking to convert light into chemical potential. Such control is especially desirable in iron(ii)-based chromophores, which are an Earth-abundant option for a wide range of photo-induced electron-transfer applications including solar energy conversion1 and catalysis2. However, the sub-200-femtosecond lifetimes of

    更新日期:2020-06-11
  • The liver-brain-gut neural arc maintains the Treg cell niche in the gut.
    Nature (IF 42.778) Pub Date : 2020-06-11
    Toshiaki Teratani,Yohei Mikami,Nobuhiro Nakamoto,Takahiro Suzuki,Yosuke Harada,Koji Okabayashi,Yuya Hagihara,Nobuhito Taniki,Keita Kohno,Shinsuke Sibata,Kentaro Miyamoto,Harumichi Ishigame,Po-Sung Chu,Tomohisa Sujino,Wataru Suda,Masahira Hattori,Minoru Matsui,Takaharu Okada,Hideyuki Okano,Masayuki Inoue,Toshihiko Yada,Yuko Kitagawa,Akihiko Yoshimura,Mamoru Tanida,Makoto Tsuda,Yusaku Iwasaki,Takanori

    The gut–brain axis, a reciprocal interaction between the central nervous system (CNS) and peripheral intestinal functions, is conceptually feasible from recent clinical and experimental evidence showing mutual interactions between the CNS and gut microbiota that are closely associated with the bidirectional effects of inflammatory bowel diseases (IBDs) and CNS disorders1–4. Despite recent advances

    更新日期:2020-06-11
Contents have been reproduced by permission of the publishers.
导出
全部期刊列表>>
材料学研究精选
胸腔和胸部成像专题
自然科研论文编辑服务
ACS ES&T Engineering
ACS ES&T Water
屿渡论文,编辑服务
杨超勇
周一歌
华东师范大学
南京工业大学
清华大学
中科大
唐勇
跟Nature、Science文章学绘图
隐藏1h前已浏览文章
中洪博元
课题组网站
新版X-MOL期刊搜索和高级搜索功能介绍
ACS材料视界
x-mol收录
福州大学
南京大学
王杰
南科大
左智伟
湖南大学
清华大学
王小野
中山大学化学工程与技术学院
试剂库存
天合科研
down
wechat
bug