Coronavirus disease 2019 (COVID-19) is an acute respiratory tract infection that emerged in late 20191,2. Initial outbreaks in China involved 13.8% cases with severe, and 6.1% with critical courses3. This severe presentation corresponds to the usage of a virus receptor that is expressed predominantly in the lung2,4. By causing an early onset of severe symptoms, this same receptor tropism is thought

A novel SARS-like coronavirus (SARS-CoV-2) recently emerged and is rapidly spreading in humans1,2. A key to tackling this epidemic is to understand the virus’s receptor recognition mechanism, which regulates its infectivity, pathogenesis and host range. SARS-CoV-2 and SARS-CoV recognize the same receptor - human ACE2 (hACE2)3,4. Here we determined the crystal structure of the SARS-CoV-2 receptor-binding

A novel and highly pathogenic coronavirus (SARS-CoV-2) has caused an outbreak in Wuhan city, Hubei province of China since December 2019, and soon spread nationwide and spilled over to other countries around the world1–3. To better understand the initial step of infection at an atomic level, we determined the crystal structure of the SARS-CoV-2 spike receptor-binding domain (RBD) bound to the cell

The ongoing outbreak of viral pneumonia in China and beyond is associated with a novel coronavirus, SARS-CoV-21. This outbreak has been tentatively associated with a seafood market in Wuhan, China, where the sale of wild animals may be the source of zoonotic infection2. Although bats are likely reservoir hosts for SARS-CoV-2, the identity of any intermediate host that might have facilitated transfer

Single-cell analysis is a valuable tool to dissect cellular heterogeneity in complex systems1. Yet, a comprehensive single-cell atlas has not been achieved for humans. We used single-cell mRNA sequencing to determine the cell-type composition of all major human organs and constructed a scheme for the human cell landscape (HCL). We revealed a single-cell hierarchy for many tissues that have not been

Frequently referred to as the ‘magic methyl effect’, installation of methyl groups, especially adjacent (α) to heteroatoms, has been shown to drastically increase the potency of bioactive molecules1–3. Current methylation methods display limited scope and have not been demonstrated in complex settings1. Here we report a regio- and chemoselective oxidative C(sp3)–H methylation method compatible with

Ultra-hot giant exoplanets receive thousands of times Earth’s insolation1,2. Their high-temperature atmospheres (greater than 2,000 kelvin) are ideal laboratories for studying extreme planetary climates and chemistry3–5. Daysides are predicted to be cloud-free, dominated by atomic species6 and substantially hotter than nightsides5,7,8. Atoms are expected to recombine into molecules over the nightside9