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  •   Integrated multiomic characterization of congenital heart disease
    Nature (IF 49.962) Pub Date : 2022-06-22
    Matthew C. Hill, Zachary A. Kadow, Hali Long, Yuka Morikawa, Thomas J. Martin, Emma J. Birks, Kenneth S. Campbell, Jeanne Nerbonne, Kory Lavine, Lalita Wadhwa, Jun Wang, Diwakar Turaga, Iki Adachi, James F. Martin

    The heart, the first organ to develop, undergoes complex morphogenesis that when defective results in congenital heart disease (CHD). With current therapies, more than 90% of CHD patients survive into adulthood but often suffer premature death from heart failure (HF) and non-cardiac causes 1. To gain insight into poorly understood disease progression, we performed single nuclear RNA sequencing (snRNA-seq)

  •   Women are Credited Less in Science than are Men
    Nature (IF 49.962) Pub Date : 2022-06-22
    Matthew B. Ross, Britta M. Glennon, Raviv Murciano-Goroff, Enrico G. Berkes, Bruce A. Weinberg, Julia I. Lane

    There is a well-documented gap in the observed number of scientific works produced by women and men in science, with clear consequences for the retention and promotion of women in science1. The gap might be a result of productivity differences2-5, or it might be due to women’s contributions not being acknowledged6,7. This paper finds that at least part of this gap is due to the latter: women in research

  •   Engineering topological states in atom-based semiconductor quantum dots
    Nature (IF 49.962) Pub Date : 2022-06-22
    M. Kiczynski, S. K. Gorman, H. Geng, M. B. Donnelly, Y. Chung, Y. He, J. G. Keizer, M. Y. Simmons
  •   Ablation of cDC2 development by triple mutations within the Zeb2 enhancer
    Nature (IF 49.962) Pub Date : 2022-06-22
    Tian-Tian Liu, Sunkyung Kim, Pritesh Desai, Do-Hyun Kim, Xiao Huang, Stephen T. Ferris, Renee Wu, Feiya Ou, Takeshi Egawa, Steven J. Van Dyken, Michael S. Diamond, Peter F. Johnson, Masato Kubo, Theresa L. Murphy, Kenneth M. Murphy
  •   Two-dimensional materials prospects for non-volatile spintronic memories
    Nature (IF 49.962) Pub Date : 2022-06-22
    Hyunsoo Yang, Sergio O. Valenzuela, Mairbek Chshiev, Sébastien Couet, Bernard Dieny, Bruno Dlubak, Albert Fert, Kevin Garello, Matthieu Jamet, Dae-Eun Jeong, Kangho Lee, Taeyoung Lee, Marie-Blandine Martin, Gouri Sankar Kar, Pierre Sénéor, Hyeon-Jin Shin, Stephan Roche
  •   Single-nucleus profiling of human dilated and hypertrophic cardiomyopathy
    Nature (IF 49.962) Pub Date : 2022-06-22
    Mark Chaffin, Irinna Papangeli, Bridget Simonson, Amer-Denis Akkad, Matthew C. Hill, Alessandro Arduini, Stephen J. Fleming, Michelle Melanson, Sikander Hayat, Maria Kost-Alimova, Ondine Atwa, Jiangchuan Ye, Kenneth C. Bedi, Matthias Nahrendorf, Virendar K. Kaushik, Christian M. Stegmann, Kenneth B. Margulies, Nathan R. Tucker, Patrick T. Ellinor
  •   Biosynthetic potential of the global ocean microbiome
    Nature (IF 49.962) Pub Date : 2022-06-22
    Lucas Paoli, Hans-Joachim Ruscheweyh, Clarissa C. Forneris, Florian Hubrich, Satria Kautsar, Agneya Bhushan, Alessandro Lotti, Quentin Clayssen, Guillem Salazar, Alessio Milanese, Charlotte I. Carlström, Chrysa Papadopoulou, Daniel Gehrig, Mikhail Karasikov, Harun Mustafa, Martin Larralde, Laura M. Carroll, Pablo Sánchez, Ahmed A. Zayed, Dylan R. Cronin, Silvia G. Acinas, Peer Bork, Chris Bowler, Tom
  •   Asymmetric pore windows in MOF membranes for natural gas valorization
    Nature (IF 49.962) Pub Date : 2022-06-22
    Sheng Zhou, Osama Shekhah, Adrian Ramírez, Pengbo Lyu, Edy Abou-Hamad, Jiangtao Jia, Jiantang Li, Prashant M. Bhatt, Zhiyuan Huang, Hao Jiang, Tian Jin, Guillaume Maurin, Jorge Gascon, Mohamed Eddaoudi
  •   Life rather than climate influences diversity at scales greater than 40 million years
    Nature (IF 49.962) Pub Date : 2022-06-22
    Andrej Spiridonov, Shaun Lovejoy
  •   Observation of a correlated free four-neutron system
    Nature (IF 49.962) Pub Date : 2022-06-22
    M. Duer, T. Aumann, R. Gernhäuser, V. Panin, S. Paschalis, D. M. Rossi, N. L. Achouri, D. Ahn, H. Baba, C. A. Bertulani, M. Böhmer, K. Boretzky, C. Caesar, N. Chiga, A. Corsi, D. Cortina-Gil, C. A. Douma, F. Dufter, Z. Elekes, J. Feng, B. Fernández-Domínguez, U. Forsberg, N. Fukuda, I. Gasparic, Z. Ge, J. M. Gheller, J. Gibelin, A. Gillibert, K. I. Hahn, Z. Halász, M. N. Harakeh, A. Hirayama, M. Holl
  •   eIF5B and eIF1A reorient initiator tRNA to allow ribosomal subunit joining
    Nature (IF 49.962) Pub Date : 2022-06-22
    Christopher P. Lapointe, Rosslyn Grosely, Masaaki Sokabe, Carlos Alvarado, Jinfan Wang, Elizabeth Montabana, Nancy Villa, Byung-Sik Shin, Thomas E. Dever, Christopher S. Fraser, Israel S. Fernández, Joseph D. Puglisi
  •   cBAF complex components and MYC cooperate early in CD8+ T cell fate
    Nature (IF 49.962) Pub Date : 2022-06-22
    Ao Guo, Hongling Huang, Zhexin Zhu, Mark J. Chen, Hao Shi, Sujing Yuan, Piyush Sharma, Jon P. Connelly, Swantje Liedmann, Yogesh Dhungana, Zhenrui Li, Dalia Haydar, Mao Yang, Helen Beere, Jason T. Yustein, Christopher DeRenzo, Shondra M. Pruett-Miller, Jeremy Chase Crawford, Giedre Krenciute, Charles W. M. Roberts, Hongbo Chi, Douglas R. Green
  •   PIEZO1 transduces mechanical itch in mice
    Nature (IF 49.962) Pub Date : 2022-06-22
    Rose Z. Hill, Meaghan C. Loud, Adrienne E. Dubin, Brooke Peet, Ardem Patapoutian
  •   Organic bipolar transistors
    Nature (IF 49.962) Pub Date : 2022-06-22
    Shu-Jen Wang, Michael Sawatzki, Ghader Darbandy, Felix Talnack, Jörn Vahland, Marc Malfois, Alexander Kloes, Stefan Mannsfeld, Hans Kleemann, Karl Leo
  •   The gut metabolite indole-3 propionate promotes nerve regeneration and repair
    Nature (IF 49.962) Pub Date : 2022-06-22
    Elisabeth Serger, Lucia Luengo-Gutierrez, Jessica S. Chadwick, Guiping Kong, Luming Zhou, Greg Crawford, Matt C. Danzi, Antonis Myridakis, Alexander Brandis, Adesola Temitope Bello, Franziska Müller, Alexandros Sanchez-Vassopoulos, Francesco De Virgiliis, Phoebe Liddell, Marc Emmanuel Dumas, Jessica Strid, Sridhar Mani, Dylan Dodd, Simone Di Giovanni
  •   Clonally expanded CD8 T cells characterize amyotrophic lateral sclerosis-4
    Nature (IF 49.962) Pub Date : 2022-06-22
    Laura Campisi, Shahab Chizari, Jessica S. Y. Ho, Anastasia Gromova, Frederic Arnold, Lorena Mosca, Xueyan Mei, Yesai Fstkchyan, Denis Torre, Cindy Beharry, Marta Garcia-Forn, Miguel Jiménez-Alcázar, Vladislav A. Korobeynikov, Jack Prazich, Zahi A. Fayad, Marcus M. Seldin, Silvia De Rubeis, Craig L. Bennett, Lyle W. Ostrow, Christian Lunetta, Massimo Squatrito, Minji Byun, Neil A. Shneider, Ning Jiang
  •   De novo design of discrete, stable 310-helix peptide assemblies
    Nature (IF 49.962) Pub Date : 2022-06-22
    Prasun Kumar, Neil G. Paterson, Jonathan Clayden, Derek N. Woolfson
  •   The metastatic spread of breast cancer accelerates during sleep
    Nature (IF 49.962) Pub Date : 2022-06-22
    Zoi Diamantopoulou, Francesc Castro-Giner, Fabienne Dominique Schwab, Christiane Foerster, Massimo Saini, Selina Budinjas, Karin Strittmatter, Ilona Krol, Bettina Seifert, Viola Heinzelmann-Schwarz, Christian Kurzeder, Christoph Rochlitz, Marcus Vetter, Walter Paul Weber, Nicola Aceto
  •   Many-body theory of positron binding to polyatomic molecules
    Nature (IF 49.962) Pub Date : 2022-06-22
    Jaroslav Hofierka, Brian Cunningham, Charlie M. Rawlins, Charles H. Patterson, Dermot G. Green
  •   Hadean isotopic fractionation of xenon retained in deep silicates
    Nature (IF 49.962) Pub Date : 2022-06-22
    Igor Rzeplinski, Chrystèle Sanloup, Eric Gilabert, Denis Horlait
  •   Cryo-EM structure of a type IV secretion system
    Nature (IF 49.962) Pub Date : 2022-06-22
    Kévin Macé, Abhinav K. Vadakkepat, Adam Redzej, Natalya Lukoyanova, Clasien Oomen, Nathalie Braun, Marta Ukleja, Fang Lu, Tiago R. D. Costa, Elena V. Orlova, David Baker, Qian Cong, Gabriel Waksman
  •   Induction of mouse totipotent stem cells by a defined chemical cocktail
    Nature (IF 49.962) Pub Date : 2022-06-21
    Yanyan Hu, Yuanyuan Yang, Pengcheng Tan, Yuxia Zhang, Mengxia Han, Jiawei Yu, Xin Zhang, Zeran Jia, Dan Wang, Yinqing Li, Tianhua Ma, Kang Liu, Sheng Ding

    In mice, only the zygotes and blastomeres from 2-cell embryos are authentic totipotent stem cells (TotiSCs), capable of producing all the differentiated cells in both embryonic and extraembryonic tissues and forming an entire organism1. However, it remains challenging whether and how TotiSCs, representing the very beginning of a life, can be established in vitro in the absence of germline cells. Here

  •   BA.2.12.1, BA.4 and BA.5 escape antibodies elicited by Omicron infection
    Nature (IF 49.962) Pub Date : 2022-06-17
    Yunlong Cao, Ayijiang Yisimayi, Fanchong Jian, Weiliang Song, Tianhe Xiao, Lei Wang, Shuo Du, Jing Wang, Qianqian Li, Xiaosu Chen, Yuanling Yu, Peng Wang, Zhiying Zhang, Pulan Liu, Ran An, Xiaohua Hao, Yao Wang, Jing Wang, Rui Feng, Haiyan Sun, Lijuan Zhao, Wen Zhang, Dong Zhao, Jiang Zheng, Lingling Yu, Can Li, Na Zhang, Rui Wang, Xiao Niu, Sijie Yang, Xuetao Song, Yangyang Chai, Ye Hu, Yansong Shi

    SARS-CoV-2 Omicron sublineages BA.2.12.1, BA.4 and BA.5 exhibit higher transmissibility over BA.21. The new variants’ receptor binding and immune evasion capability require immediate investigation. Here, coupled with Spike structural comparisons, we show that BA.2.12.1 and BA.4/BA.5 exhibit comparable ACE2-binding affinities to BA.2. Importantly, BA.2.12.1 and BA.4/BA.5 display stronger neutralization

  •   Site-selective, stereocontrolled glycosylation of minimally protected sugars
    Nature (IF 49.962) Pub Date : 2022-06-16
    Qiuhan Li, Samuel M. Levi, Corin Wagen, Alison E. Wendlandt, Eric N. Jacobsen

    The identification of general and efficient methods for the construction of oligosaccharides stands as one of the great challenges for the field of synthetic chemistry1,2. Selective glycosylation of unprotected sugars and other polyhydroxylated nucleophiles is a particularly significant goal, requiring not only control over the stereochemistry of the forming bond but also differentiation between similarly

  •   Spatial profiling of early primate gastrulation in utero
    Nature (IF 49.962) Pub Date : 2022-06-16
    Sophie Bergmann, Christopher A. Penfold, Erin Slatery, Dylan Siriwardena, Charis Drummer, Stephen Clark, Stanley E. Strawbridge, Keiko Kishimoto, Alice Vickers, Mukul Tewary, Timo N. Kohler, Florian Hollfelder, Wolf Reik, Erika Sasaki, Rüdiger Behr, Thorsten E. Boroviak

    Gastrulation controls the emergence of cellular diversity and axis patterning in the early embryo. In mammals, this transformation is orchestrated by dynamic signalling centres at the interface of embryonic and extraembryonic tissues1–3. Elucidating the molecular framework of axis formation in vivo is fundamental for our understanding of human development4–6 and to advance stem-cell-based regenerative

  •   Evidence for unconventional superconductivity in twisted trilayer graphene
    Nature (IF 49.962) Pub Date : 2022-06-15
    Hyunjin Kim, Youngjoon Choi, Cyprian Lewandowski, Alex Thomson, Yiran Zhang, Robert Polski, Kenji Watanabe, Takashi Taniguchi, Jason Alicea, Stevan Nadj-Perge

    Magic-angle twisted trilayer graphene (MATTG) has emerged as a moiré material that exhibits strong electronic correlations and unconventional superconductivity1,2. However, local spectroscopic studies of this system are still lacking. Here we perform high-resolution scanning tunnelling microscopy and spectroscopy of MATTG that reveal extensive regions of atomic reconstruction favouring mirror-symmetric

  •   The source of the Black Death in fourteenth-century central Eurasia
    Nature (IF 49.962) Pub Date : 2022-06-15
    Maria A. Spyrou, Lyazzat Musralina, Guido A. Gnecchi Ruscone, Arthur Kocher, Pier-Giorgio Borbone, Valeri I. Khartanovich, Alexandra Buzhilova, Leyla Djansugurova, Kirsten I. Bos, Denise Kühnert, Wolfgang Haak, Philip Slavin, Johannes Krause

    The origin of the medieval Black Death pandemic (ad 1346–1353) has been a topic of continuous investigation because of the pandemic’s extensive demographic impact and long-lasting consequences1,2. Until now, the most debated archaeological evidence potentially associated with the pandemic’s initiation derives from cemeteries located near Lake Issyk-Kul of modern-day Kyrgyzstan1,3,4,5,6,7,8,9. These

  •   Superconducting-qubit readout via low-backaction electro-optic transduction
    Nature (IF 49.962) Pub Date : 2022-06-15
    R. D. Delaney, M. D. Urmey, S. Mittal, B. M. Brubaker, J. M. Kindem, P. S. Burns, C. A. Regal, K. W. Lehnert

    Entangling microwave-frequency superconducting quantum processors through optical light at ambient temperature would enable means of secure communication and distributed quantum information processing1. However, transducing quantum signals between these disparate regimes of the electro-magnetic spectrum remains an outstanding goal2,3,4,5,6,7,8,9, and interfacing superconducting qubits, which are constrained

  •   Androgen receptor blockade promotes response to BRAF/MEK-targeted therapy
    Nature (IF 49.962) Pub Date : 2022-06-15
    Christopher P. Vellano, Michael G. White, Miles C. Andrews, Manoj Chelvanambi, Russell G. Witt, Joseph R. Daniele, Mark Titus, Jennifer L. McQuade, Fabio Conforti, Elizabeth M. Burton, Matthew J. Lastrapes, Gabriel Ologun, Alexandria P. Cogdill, Golnaz Morad, Peter Prieto, Alexander J. Lazar, Yanshuo Chu, Guangchun Han, M. A. Wadud Khan, Beth Helmink, Michael A. Davies, Rodabe N. Amaria, Jeffrey J

    Treatment with therapy targeting BRAF and MEK (BRAF/MEK) has revolutionized care in melanoma and other cancers; however, therapeutic resistance is common and innovative treatment strategies are needed1,2. Here we studied a group of patients with melanoma who were treated with neoadjuvant BRAF/MEK-targeted therapy (NCT02231775, n = 51) and observed significantly higher rates of major pathological response

  •   Mechanism of replication origin melting nucleated by CMG helicase assembly
    Nature (IF 49.962) Pub Date : 2022-06-15
    Jacob S. Lewis, Marta H. Gross, Joana Sousa, Sarah S. Henrikus, Julia F. Greiwe, Andrea Nans, John F. X. Diffley, Alessandro Costa

    The activation of eukaryotic origins of replication occurs in temporally separated steps to ensure that chromosomes are copied only once per cell cycle. First, the MCM helicase is loaded onto duplex DNA as an inactive double hexamer. Activation occurs after the recruitment of a set of firing factors that assemble two Cdc45–MCM–GINS (CMG) holo-helicases. CMG formation leads to the underwinding of DNA

  •   A pan-cancer compendium of chromosomal instability
    Nature (IF 49.962) Pub Date : 2022-06-15
    Ruben M. Drews, Barbara Hernando, Maxime Tarabichi, Kerstin Haase, Tom Lesluyes, Philip S. Smith, Lena Morrill Gavarró, Dominique-Laurent Couturier, Lydia Liu, Michael Schneider, James D. Brenton, Peter Van Loo, Geoff Macintyre, Florian Markowetz

    Chromosomal instability (CIN) results in the accumulation of large-scale losses, gains and rearrangements of DNA1. The broad genomic complexity caused by CIN is a hallmark of cancer2; however, there is no systematic framework to measure different types of CIN and their effect on clinical phenotypes pan-cancer. Here we evaluate the extent, diversity and origin of CIN across 7,880 tumours representing

  •   Deciphering the immunopeptidome in vivo reveals new tumour antigens
    Nature (IF 49.962) Pub Date : 2022-06-15
    Alex M. Jaeger, Lauren E. Stopfer, Ryuhjin Ahn, Emma A. Sanders, Demi A. Sandel, William A. Freed-Pastor, William M. Rideout, Santiago Naranjo, Tim Fessenden, Kim B. Nguyen, Peter S. Winter, Ryan E. Kohn, Peter M. K. Westcott, Jason M. Schenkel, Sean-Luc Shanahan, Alex K. Shalek, Stefani Spranger, Forest M. White, Tyler Jacks

    Immunosurveillance of cancer requires the presentation of peptide antigens on major histocompatibility complex class I (MHC-I) molecules1,2,3,4,5. Current approaches to profiling of MHC-I-associated peptides, collectively known as the immunopeptidome, are limited to in vitro investigation or bulk tumour lysates, which limits our understanding of cancer-specific patterns of antigen presentation in vivo6

  •   Peptidoglycan maturation controls outer membrane protein assembly
    Nature (IF 49.962) Pub Date : 2022-06-15
    Gideon Mamou, Federico Corona, Ruth Cohen-Khait, Nicholas G. Housden, Vivian Yeung, Dawei Sun, Pooja Sridhar, Manuel Pazos, Timothy J. Knowles, Colin Kleanthous, Waldemar Vollmer

    Linkages between the outer membrane of Gram-negative bacteria and the peptidoglycan layer are crucial for the maintenance of cellular integrity and enable survival in challenging environments1,2,3,4,5. The function of the outer membrane is dependent on outer membrane proteins (OMPs), which are inserted into the membrane by the β-barrel assembly machine6,7 (BAM). Growing Escherichia coli cells segregate

  •   A population of ultraviolet-dim protoclusters detected in absorption
    Nature (IF 49.962) Pub Date : 2022-06-15
    Andrew B. Newman, Gwen C. Rudie, Guillermo A. Blanc, Mahdi Qezlou, Simeon Bird, Daniel D. Kelson, Victoria Pérez, Enrico Congiu, Brian C. Lemaux, Alan Dressler, John S. Mulchaey

    Galaxy protoclusters, which will eventually grow into the massive clusters we see in the local Universe, are usually traced by locating overdensities of galaxies1. Large spectroscopic surveys of distant galaxies now exist, but their sensitivity depends mainly on a galaxy’s star-formation activity and dust content rather than its mass. Tracers of massive protoclusters that do not rely on their galaxy

  •   Signatures of copy number alterations in human cancer
    Nature (IF 49.962) Pub Date : 2022-06-15
    Christopher D. Steele, Ammal Abbasi, S. M. Ashiqul Islam, Amy L. Bowes, Azhar Khandekar, Kerstin Haase, Shadi Hames-Fathi, Dolapo Ajayi, Annelien Verfaillie, Pawan Dhami, Alex McLatchie, Matt Lechner, Nicholas Light, Adam Shlien, David Malkin, Andrew Feber, Paula Proszek, Tom Lesluyes, Fredrik Mertens, Adrienne M. Flanagan, Maxime Tarabichi, Peter Van Loo, Ludmil B. Alexandrov, Nischalan Pillay

    Gains and losses of DNA are prevalent in cancer and emerge as a consequence of inter-related processes of replication stress, mitotic errors, spindle multipolarity and breakage–fusion–bridge cycles, among others, which may lead to chromosomal instability and aneuploidy1,2. These copy number alterations contribute to cancer initiation, progression and therapeutic resistance3,4,5. Here we present a conceptual

  •   Caspase-7 activates ASM to repair gasdermin and perforin pores
    Nature (IF 49.962) Pub Date : 2022-06-15
    Kengo Nozaki, Vivien I. Maltez, Manira Rayamajhi, Alan L. Tubbs, Joseph E. Mitchell, Carolyn A. Lacey, Carissa K. Harvest, Lupeng Li, William T. Nash, Heather N. Larson, Benjamin D. McGlaughon, Nathaniel J. Moorman, Michael G. Brown, Jason K. Whitmire, Edward A. Miao

    Among the caspases that cause regulated cell death, a unique function for caspase-7 has remained elusive. Caspase-3 performs apoptosis, whereas caspase-7 is typically considered an inefficient back-up. Caspase-1 activates gasdermin D pores to lyse the cell; however, caspase-1 also activates caspase-7 for unknown reasons1. Caspases can also trigger cell-type-specific death responses; for example, caspase-1

  •   Lifelong multilineage contribution by embryonic-born blood progenitors
    Nature (IF 49.962) Pub Date : 2022-06-15
    Sachin H. Patel, Constantina Christodoulou, Caleb Weinreb, Qi Yu, Edroaldo Lummertz da Rocha, Brian J. Pepe-Mooney, Sarah Bowling, Li Li, Fernando G. Osorio, George Q. Daley, Fernando D. Camargo

    Haematopoietic stem cells (HSCs) arise in the embryo from the arterial endothelium through a process known as the endothelial-to-haematopoietic transition (EHT)1,2,3,4. This process generates hundreds of blood progenitors, of which a fraction go on to become definitive HSCs. It is generally thought that most adult blood is derived from those HSCs, but to what extent other progenitors contribute to

  •   Synthesis of a monolayer fullerene network
    Nature (IF 49.962) Pub Date : 2022-06-15
    Lingxiang Hou, Xueping Cui, Bo Guan, Shaozhi Wang, Ruian Li, Yunqi Liu, Daoben Zhu, Jian Zheng

    Two-dimensional (2D) carbon materials, such as graphene, have attracted particular attention owing to the exceptional carrier transport characteristics that arise from the unique π-electron system in their conjugated carbon network structure1,2,3,4. To complement zero-bandgap graphene, material scientists have devoted considerable effort to identifying 2D carbon materials5,6,7,8. However, it is a challenge

  •   An exercise-inducible metabolite that suppresses feeding and obesity
    Nature (IF 49.962) Pub Date : 2022-06-15
    Veronica L. Li, Yang He, Kévin Contrepois, Hailan Liu, Joon T. Kim, Amanda L. Wiggenhorn, Julia T. Tanzo, Alan Sheng-Hwa Tung, Xuchao Lyu, Peter-James H. Zushin, Robert S. Jansen, Basil Michael, Kang Yong Loh, Andrew C. Yang, Christian S. Carl, Christian T. Voldstedlund, Wei Wei, Stephanie M. Terrell, Benjamin C. Moeller, Rick M. Arthur, Gareth A. Wallis, Koen van de Wetering, Andreas Stahl, Bente

    Exercise confers protection against obesity, type 2 diabetes and other cardiometabolic diseases1,2,3,4,5. However, the molecular and cellular mechanisms that mediate the metabolic benefits of physical activity remain unclear6. Here we show that exercise stimulates the production of N-lactoyl-phenylalanine (Lac-Phe), a blood-borne signalling metabolite that suppresses feeding and obesity. The biosynthesis

  •   cGAS–STING drives the IL-6-dependent survival of chromosomally instable cancers
    Nature (IF 49.962) Pub Date : 2022-06-15
    Christy Hong, Michael Schubert, Andréa E. Tijhuis, Marta Requesens, Maurits Roorda, Anouk van den Brink, Lorena Andrade Ruiz, Petra L. Bakker, Tineke van der Sluis, Wietske Pieters, Mengting Chen, René Wardenaar, Bert van der Vegt, Diana C. J. Spierings, Marco de Bruyn, Marcel A. T. M. van Vugt, Floris Foijer

    Chromosomal instability (CIN) drives cancer cell evolution, metastasis and therapy resistance, and is associated with poor prognosis1. CIN leads to micronuclei that release DNA into the cytoplasm after rupture, which triggers activation of inflammatory signalling mediated by cGAS and STING2,3. These two proteins are considered to be tumour suppressors as they promote apoptosis and immunosurveillance

  •   Measurement of the bound-electron g-factor difference in coupled ions
    Nature (IF 49.962) Pub Date : 2022-06-15
    Tim Sailer, Vincent Debierre, Zoltán Harman, Fabian Heiße, Charlotte König, Jonathan Morgner, Bingsheng Tu, Andrey V. Volotka, Christoph H. Keitel, Klaus Blaum, Sven Sturm

    Quantum electrodynamics (QED) is one of the most fundamental theories of physics and has been shown to be in excellent agreement with experimental results1,2,3,4,5. In particular, measurements of the electron’s magnetic moment (or g factor) of highly charged ions in Penning traps provide a stringent probe for QED, which allows testing of the standard model in the strongest electromagnetic fields6.

  •   Global Tonga tsunami explained by a fast-moving atmospheric source
    Nature (IF 49.962) Pub Date : 2022-06-13
    R. Omira, R. S. Ramalho, J. Kim, P. J. González, U. Kadri, J. M. Miranda, F. Carrilho, M. A. Baptista

    Volcanoes can produce tsunamis through earthquakes, caldera and flank collapses, pyroclastic flows, or underwater explosions1,2,3,4. These mechanisms rarely displace enough water to trigger transoceanic tsunamis. Violent volcanic explosions, however, can cause global tsunamis1,5 by triggering acoustic-gravity waves6,7,8 that excite the atmosphere-ocean interface. The colossal eruption of the Hunga

  •   Axial Higgs mode detected by quantum pathway interference in RTe3
    Nature (IF 49.962) Pub Date : 2022-06-08
    Yiping Wang, Ioannis Petrides, Grant McNamara, Md Mofazzel Hosen, Shiming Lei, Yueh-Chun Wu, James L. Hart, Hongyan Lv, Jun Yan, Di Xiao, Judy J. Cha, Prineha Narang, Leslie M. Schoop, Kenneth S. Burch

    The observation of the Higgs boson solidified the standard model of particle physics. However, explanations of anomalies (for example, dark matter) rely on further symmetry breaking, calling for an undiscovered axial Higgs mode1. The Higgs mode was also seen in magnetic, superconducting and charge density wave (CDW) systems2,3. Uncovering the vector properties of a low-energy mode is challenging, and

  •   ATGL is a biosynthetic enzyme for fatty acid esters of hydroxy fatty acids
    Nature (IF 49.962) Pub Date : 2022-06-08
    Rucha Patel, Anna Santoro, Peter Hofer, Dan Tan, Monika Oberer, Andrew T. Nelson, Srihari Konduri, Dionicio Siegel, Rudolf Zechner, Alan Saghatelian, Barbara B. Kahn

    Branched fatty acid (FA) esters of hydroxy FAs (HFAs; FAHFAs) are recently discovered lipids that are conserved from yeast to mammals1,2. A subfamily, palmitic acid esters of hydroxy stearic acids (PAHSAs), are anti-inflammatory and anti-diabetic1,3. Humans and mice with insulin resistance have lower PAHSA levels in subcutaneous adipose tissue and serum1. PAHSA administration improves glucose tolerance

  •   Genome evolution and diversity of wild and cultivated potatoes
    Nature (IF 49.962) Pub Date : 2022-06-08
    Dié Tang, Yuxin Jia, Jinzhe Zhang, Hongbo Li, Lin Cheng, Pei Wang, Zhigui Bao, Zhihong Liu, Shuangshuang Feng, Xijian Zhu, Dawei Li, Guangtao Zhu, Hongru Wang, Yao Zhou, Yongfeng Zhou, Glenn J. Bryan, C. Robin Buell, Chunzhi Zhang, Sanwen Huang

    Potato (Solanum tuberosum L.) is the world’s most important non-cereal food crop, and the vast majority of commercially grown cultivars are highly heterozygous tetraploids. Advances in diploid hybrid breeding based on true seeds have the potential to revolutionize future potato breeding and production1,2,3,4. So far, relatively few studies have examined the genome evolution and diversity of wild and

  •   Graph pangenome captures missing heritability and empowers tomato breeding
    Nature (IF 49.962) Pub Date : 2022-06-08
    Yao Zhou, Zhiyang Zhang, Zhigui Bao, Hongbo Li, Yaqing Lyu, Yanjun Zan, Yaoyao Wu, Lin Cheng, Yuhan Fang, Kun Wu, Jinzhe Zhang, Hongjun Lyu, Tao Lin, Qiang Gao, Surya Saha, Lukas Mueller, Zhangjun Fei, Thomas Städler, Shizhong Xu, Zhiwu Zhang, Doug Speed, Sanwen Huang

    Missing heritability in genome-wide association studies defines a major problem in genetic analyses of complex biological traits1,2. The solution to this problem is to identify all causal genetic variants and to measure their individual contributions3,4. Here we report a graph pangenome of tomato constructed by precisely cataloguing more than 19 million variants from 838 genomes, including 32 new reference-level

  •   Potentiating adoptive cell therapy using synthetic IL-9 receptors
    Nature (IF 49.962) Pub Date : 2022-06-08
    Anusha Kalbasi, Mikko Siurala, Leon L. Su, Mito Tariveranmoshabad, Lora K. Picton, Pranali Ravikumar, Peng Li, Jian-Xin Lin, Helena Escuin-Ordinas, Tong Da, Sarah V. Kremer, Amy L. Sun, Sofia Castelli, Sangya Agarwal, John Scholler, Decheng Song, Philipp C. Rommel, Enrico Radaelli, Regina M. Young, Warren J. Leonard, Antoni Ribas, Carl H. June, K. Christopher Garcia

    Synthetic receptor signalling has the potential to endow adoptively transferred T cells with new functions that overcome major barriers in the treatment of solid tumours, including the need for conditioning chemotherapy1,2. Here we designed chimeric receptors that have an orthogonal IL-2 receptor extracellular domain (ECD) fused with the intracellular domain (ICD) of receptors for common γ-chain (γc)

  •   Origin of structural degradation in Li-rich layered oxide cathode
    Nature (IF 49.962) Pub Date : 2022-06-08
    Tongchao Liu, Jiajie Liu, Luxi Li, Lei Yu, Jiecheng Diao, Tao Zhou, Shunning Li, Alvin Dai, Wenguang Zhao, Shenyang Xu, Yang Ren, Liguang Wang, Tianpin Wu, Rui Qi, Yinguo Xiao, Jiaxin Zheng, Wonsuk Cha, Ross Harder, Ian Robinson, Jianguo Wen, Jun Lu, Feng Pan, Khalil Amine

    Li- and Mn-rich (LMR) cathode materials that utilize both cation and anion redox can yield substantial increases in battery energy density1,2,3. However, although voltage decay issues cause continuous energy loss and impede commercialization, the prerequisite driving force for this phenomenon remains a mystery3,4,5,6 Here, with in situ nanoscale sensitive coherent X-ray diffraction imaging techniques

  •   Synonymous mutations in representative yeast genes are mostly strongly non-neutral
    Nature (IF 49.962) Pub Date : 2022-06-08
    Xukang Shen, Siliang Song, Chuan Li, Jianzhi Zhang

    Synonymous mutations in protein-coding genes do not alter protein sequences and are thus generally presumed to be neutral or nearly neutral1,2,3,4,5. Here, to experimentally verify this presumption, we constructed 8,341 yeast mutants each carrying a synonymous, nonsynonymous or nonsense mutation in one of 21 endogenous genes with diverse functions and expression levels and measured their fitness relative

  •   The renal lineage factor PAX8 controls oncogenic signalling in kidney cancer
    Nature (IF 49.962) Pub Date : 2022-06-08
    Saroor A. Patel, Shoko Hirosue, Paulo Rodrigues, Erika Vojtasova, Emma K. Richardson, Jianfeng Ge, Saiful E. Syafruddin, Alyson Speed, Evangelia K. Papachristou, David Baker, David Clarke, Stephenie Purvis, Ludovic Wesolowski, Anna Dyas, Leticia Castillon, Veronica Caraffini, Dóra Bihary, Cissy Yong, David J. Harrison, Grant D. Stewart, Mitchell J. Machiela, Mark P. Purdue, Stephen J. Chanock, Anne

    Large-scale human genetic data1,2,3 have shown that cancer mutations display strong tissue-selectivity, but how this selectivity arises remains unclear. Here, using experimental models, functional genomics and analyses of patient samples, we demonstrate that the lineage transcription factor paired box 8 (PAX8) is required for oncogenic signalling by two common genetic alterations that cause clear cell

  •   Mechanism of mitoribosomal small subunit biogenesis and preinitiation
    Nature (IF 49.962) Pub Date : 2022-06-08
    Yuzuru Itoh, Anas Khawaja, Ivan Laptev, Miriam Cipullo, Ilian Atanassov, Petr Sergiev, Joanna Rorbach, Alexey Amunts

    Mitoribosomes are essential for the synthesis and maintenance of bioenergetic proteins. Here we use cryo-electron microscopy to determine a series of the small mitoribosomal subunit (SSU) intermediates in complex with auxiliary factors, revealing a sequential assembly mechanism. The methyltransferase TFB1M binds to partially unfolded rRNA h45 that is promoted by RBFA, while the mRNA channel is blocked

  •   Pregnancy enables antibody protection against intracellular infection
    Nature (IF 49.962) Pub Date : 2022-06-08
    John J. Erickson, Stephanie Archer-Hartmann, Alexander E. Yarawsky, Jeanette L. C. Miller, Stephanie Seveau, Tzu-Yu Shao, Ashley L. Severance, Hilary Miller-Handley, Yuehong Wu, Giang Pham, Brian R. Wasik, Colin R. Parrish, Yueh-Chiang Hu, Joseph T. Y. Lau, Parastoo Azadi, Andrew B. Herr, Sing Sing Way

    Adaptive immune components are thought to exert non-overlapping roles in antimicrobial host defence, with antibodies targeting pathogens in the extracellular environment and T cells eliminating infection inside cells1,2. Reliance on antibodies for vertically transferred immunity from mothers to babies may explain neonatal susceptibility to intracellular infections3,4. Here we show that pregnancy-induced

  •   Continuous Bose–Einstein condensation
    Nature (IF 49.962) Pub Date : 2022-06-08
    Chun-Chia Chen, Rodrigo González Escudero, Jiří Minář, Benjamin Pasquiou, Shayne Bennetts, Florian Schreck

    Bose–Einstein condensates (BECs) are macroscopic coherent matter waves that have revolutionized quantum science and atomic physics. They are important to quantum simulation1 and sensing2,3, for example, underlying atom interferometers in space4 and ambitious tests of Einstein’s equivalence principle5,6. A long-standing constraint for quantum gas devices has been the need to execute cooling stages time-sequentially

  •   Constraining neutron-star matter with microscopic and macroscopic collisions
    Nature (IF 49.962) Pub Date : 2022-06-08
    Sabrina Huth, Peter T. H. Pang, Ingo Tews, Tim Dietrich, Arnaud Le Fèvre, Achim Schwenk, Wolfgang Trautmann, Kshitij Agarwal, Mattia Bulla, Michael W. Coughlin, Chris Van Den Broeck

    Interpreting high-energy, astrophysical phenomena, such as supernova explosions or neutron-star collisions, requires a robust understanding of matter at supranuclear densities. However, our knowledge about dense matter explored in the cores of neutron stars remains limited. Fortunately, dense matter is not probed only in astrophysical observations, but also in terrestrial heavy-ion collision experiments

  •   Nanoscale imaging of phonon dynamics by electron microscopy
    Nature (IF 49.962) Pub Date : 2022-06-08
    Chaitanya A. Gadre, Xingxu Yan, Qichen Song, Jie Li, Lei Gu, Huaixun Huyan, Toshihiro Aoki, Sheng-Wei Lee, Gang Chen, Ruqian Wu, Xiaoqing Pan

    Spatially resolved vibrational mapping of nanostructures is indispensable to the development and understanding of thermal nanodevices1, modulation of thermal transport2 and novel nanostructured thermoelectric materials3,4,5. Through the engineering of complex structures, such as alloys, nanostructures and superlattice interfaces, one can significantly alter the propagation of phonons and suppress material

  •   A repeating fast radio burst associated with a persistent radio source
    Nature (IF 49.962) Pub Date : 2022-06-08
    C.-H. Niu, K. Aggarwal, D. Li, X. Zhang, S. Chatterjee, C.-W. Tsai, W. Yu, C. J. Law, S. Burke-Spolaor, J. M. Cordes, Y.-K. Zhang, S. K. Ocker, J.-M. Yao, P. Wan, Y. Feng, Y. Niino, C. Bochenek, M. Cruces, L. Connor, J.-A. Jiang, S. Dai, R. Luo, G.-D. Li, C.-C. Miao, J.-R. Niu, R. Anna-Thomas, J. Sydnor, D. Stern, W.-Y. Wang, M. Yuan, Y.-L. Yue, D.-J. Zhou, Z. Yan, W.-W. Zhu, B. Zhang

    The dispersive sweep of fast radio bursts (FRBs) has been used to probe the ionized baryon content of the intergalactic medium1, which is assumed to dominate the total extragalactic dispersion. Although the host-galaxy contributions to the dispersion measure appear to be small for most FRBs2, in at least one case there is evidence for an extreme magneto-ionic local environment3,4 and a compact persistent

  •   Structural basis of GABA reuptake inhibition
    Nature (IF 49.962) Pub Date : 2022-06-08
    Zenia Motiwala, Nanda Gowtham Aduri, Hamidreza Shaye, Gye Won Han, Jordy Homing Lam, Vsevolod Katritch, Vadim Cherezov, Cornelius Gati

    γ-Aminobutyric acid (GABA) transporter 1 (GAT1)1 regulates neuronal excitation of the central nervous system by clearing the synaptic cleft of the inhibitory neurotransmitter GABA upon its release from synaptic vesicles. Elevating the levels of GABA in the synaptic cleft, by inhibiting GABA reuptake transporters, is an established strategy to treat neurological disorders, such as epilepsy2. Here we

  •   Observation of Cooper pairs in a mesoscopic two-dimensional Fermi gas
    Nature (IF 49.962) Pub Date : 2022-06-08
    Marvin Holten, Luca Bayha, Keerthan Subramanian, Sandra Brandstetter, Carl Heintze, Philipp Lunt, Philipp M. Preiss, Selim Jochim

    The formation of strongly correlated fermion pairs is fundamental for the emergence of fermionic superfluidity and superconductivity1. For instance, Cooper pairs made of two electrons of opposite spin and momentum at the Fermi surface of the system are a key ingredient of Bardeen–Cooper–Schrieffer (BCS) theory—the microscopic explanation of the emergence of conventional superconductivity2. Understanding

  •   A preoptic neuronal population controls fever and appetite during sickness
    Nature (IF 49.962) Pub Date : 2022-06-08
    Jessica A. Osterhout, Vikrant Kapoor, Stephen W. Eichhorn, Eric Vaughn, Jeffrey D. Moore, Ding Liu, Dean Lee, Laura A. DeNardo, Liqun Luo, Xiaowei Zhuang, Catherine Dulac

    During infection, animals exhibit adaptive changes in physiology and behaviour aimed at increasing survival. Although many causes of infection exist, they trigger similar stereotyped symptoms such as fever, warmth-seeking, loss of appetite and fatigue1,2. Yet exactly how the nervous system alters body temperature and triggers sickness behaviours to coordinate responses to infection remains unknown

  •   Core control principles of the eukaryotic cell cycle
    Nature (IF 49.962) Pub Date : 2022-06-08
    Souradeep Basu, Jessica Greenwood, Andrew W. Jones, Paul Nurse

    Cyclin-dependent kinases (CDKs) lie at the heart of eukaryotic cell cycle control, with different cyclin–CDK complexes initiating DNA replication (S-CDKs) and mitosis (M-CDKs)1,2. However, the principles on which cyclin–CDK complexes organize the temporal order of cell cycle events are contentious3. One model proposes that S-CDKs and M-CDKs are functionally specialized, with substantially different

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