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Erratum: Schiapparelli et al., "Activity-Induced Cortical Glutamatergic Neuron Nascent Proteins". J. Neurosci. (IF 6.709) Pub Date : 2023-05-30
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Postsynaptic protein Shank3a deficiency synergizes with Alzheimer's disease neuropathology to impair cognitive performance in the 3xTg-AD murine model. J. Neurosci. (IF 6.709) Pub Date : 2023-05-30 Olivier Landry,Arnaud François,Méryl-Farelle Oye Mintsa Mi-Mba,Marie-Therese Traversy,Cyntia Tremblay,Vincent Emond,David A Bennett,Karen H Gylys,Joseph D Buxbaum,Frederic Calon
Synaptic loss is intrinsically linked to Alzheimer's disease (AD) neuropathology and symptoms, but its direct impact on clinical symptoms remains elusive. The postsynaptic protein Shank3 (SH3 and multiple ankyrin repeat domains) is of particular interest, as the loss of a single allele of the SHANK3 gene is sufficient to cause profound cognitive symptoms in children. We thus sought to determine whether
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Neuronally-derived soluble Abeta evokes cell-wide astrocytic calcium dysregulation in absence of amyloid plaques in vivo. J. Neurosci. (IF 6.709) Pub Date : 2023-05-26 P Kelly,M V Sanchez-Mico,S S Hou,S Whiteman,A Russ,E Hudry,M Arbel-Ornath,S M Greenberg,B J Bacskai
The key pathological entities driving the destruction of synaptic function and integrity during the evolution of Alzheimer's disease (AD) remains elusive. Astrocytes are structurally and functionally integrated within synaptic and vascular circuitry and use calcium-based physiology to modulate basal synaptic transmission, vascular dynamics and neurovascular coupling, which are central to AD pathogenesis
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Diminished Neuronal ESCRT-0 Function Exacerbates AMPA Receptor Derangement and Accelerates Prion-Induced Neurodegeneration J. Neurosci. (IF 6.709) Pub Date : 2023-05-24 Jessica A. Lawrence, Patricia Aguilar-Calvo, Daniel Ojeda-Juárez, Helen Khuu, Katrin Soldau, Donald P. Pizzo, Jin Wang, Adela Malik, Timothy F. Shay, Erin E. Sullivan, Brent Aulston, Seung Min Song, Julia A. Callender, Henry Sanchez, Michael D. Geschwind, Subhojit Roy, Robert A. Rissman, JoAnn Trejo, Nobuyuki Tanaka, Chengbiao Wu, Xu Chen, Gentry N. Patrick, Christina J. Sigurdson
Endolysosomal defects in neurons are central to the pathogenesis of prion and other neurodegenerative disorders. In prion disease, prion oligomers traffic through the multivesicular body (MVB) and are routed for degradation in lysosomes or for release in exosomes, yet how prions impact proteostatic pathways is unclear. We found that prion-affected human and mouse brain showed a marked reduction in
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CSMD3 Deficiency Leads to Motor Impairments and Autism-Like Behaviors via Dysfunction of Cerebellar Purkinje Cells in Mice J. Neurosci. (IF 6.709) Pub Date : 2023-05-24 Ke Xi, Si-Qing Cai, Hui-Fang Yan, Yue Tian, Jie Cai, Xiao-Mei Yang, Jing-Min Wang, Guo-Gang Xing
Autism spectrum disorder (ASD) is a neurodevelopmental disorder with highly heritable heterogeneity. Mutations of CUB and sushi multiple domains 3 (CSMD3) gene have been reported in individuals with ASD. However, the underlying mechanisms of CSMD3 for the onset of ASD remain unexplored. Here, using male CSMD3 knock-out (CSMD3–/–) mice, we found that genetic deletion of CSMD3 produced core autistic-like
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NMDA Receptors at Primary Afferent-Excitatory Neuron Synapses Differentially Sustain Chemotherapy- and Nerve Trauma-Induced Chronic Pain J. Neurosci. (IF 6.709) Pub Date : 2023-05-24 Yuying Huang, Hong Chen, Daozhong Jin, Shao-Rui Chen, Hui-Lin Pan
The spinal dorsal horn contains vesicular glutamate transporter-2 (VGluT2)-expressing excitatory neurons and vesicular GABA transporter (VGAT)-expressing inhibitory neurons, which normally have different roles in nociceptive transmission. Spinal glutamate NMDAR hyperactivity is a crucial mechanism of chronic neuropathic pain. However, it is unclear how NMDARs regulate primary afferent input to spinal
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Anticipation of Appetitive Operant Action Induces Sustained Dopamine Release in the Nucleus Accumbens J. Neurosci. (IF 6.709) Pub Date : 2023-05-24 Jessica Goedhoop, Tara Arbab, Ingo Willuhn
The mesolimbic dopamine system is implicated in signaling reward-related information as well as in actions that generate rewarding outcomes. These implications are commonly investigated in either pavlovian or operant reinforcement paradigms, where only the latter requires instrumental action. To parse contributions of reward- and action-related information to dopamine signals, we directly compared
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Phase Alignment of Low-Frequency Neural Activity to the Amplitude Envelope of Speech Reflects Evoked Responses to Acoustic Edges, Not Oscillatory Entrainment J. Neurosci. (IF 6.709) Pub Date : 2023-05-24 Yulia Oganian, Katsuaki Kojima, Assaf Breska, Chang Cai, Anne Findlay, Edward Chang, Srikantan S. Nagarajan
The amplitude envelope of speech is crucial for accurate comprehension. Considered a key stage in speech processing, the phase of neural activity in the theta-delta bands (1-10 Hz) tracks the phase of the speech amplitude envelope during listening. However, the mechanisms underlying this envelope representation have been heavily debated. A dominant model posits that envelope tracking reflects entrainment
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From Prediction to Action: Dissociable Roles of Ventral Tegmental Area and Substantia Nigra Dopamine Neurons in Instrumental Reinforcement J. Neurosci. (IF 6.709) Pub Date : 2023-05-24 Kurt M. Fraser, Heather J. Pribut, Patricia H. Janak, Ronald Keiflin
Reward seeking requires the coordination of motor programs to achieve goals. Midbrain dopamine neurons are critical for reinforcement, and their activation is sufficient for learning about cues, actions, and outcomes. Here we examine in detail the mechanisms underlying the ability of ventral tegmental area (VTA) and substantia nigra (SNc) dopamine neurons to support instrumental learning. By exploiting
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Human-Like Modulation Sensitivity Emerging through Optimization to Natural Sound Recognition J. Neurosci. (IF 6.709) Pub Date : 2023-05-24 Takuya Koumura, Hiroki Terashima, Shigeto Furukawa
Natural sounds contain rich patterns of amplitude modulation (AM), which is one of the essential sound dimensions for auditory perception. The sensitivity of human hearing to AM measured by psychophysics takes diverse forms depending on the experimental conditions. Here, we address with a single framework the questions of why such patterns of AM sensitivity have emerged in the human auditory system
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Perceptual History Biases Are Predicted by Early Visual-Evoked Activity J. Neurosci. (IF 6.709) Pub Date : 2023-05-24 Michele Fornaciai, Irene Togoli, Domenica Bueti
What we see in the present is affected by what we saw in the recent past. Serial dependence, a bias making a current stimulus appear more similar to a previous one, has been indeed shown to be ubiquitous in vision. At the neural level, serial dependence is accompanied by a signature of stimulus history (i.e., past stimulus information) emerging from early visual-evoked activity. However, whether this
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Neither Enhanced Nor Lost: The Unique Role of Attention in Children's Neural Representations J. Neurosci. (IF 6.709) Pub Date : 2023-05-24 Yaelan Jung, Tess Allegra Forest, Dirk B. Walther, Amy S. Finn
A defining feature of children's cognition is the especially slow development of their attention. Despite a rich behavioral literature characterizing the development of attention, little is known about how developing attentional abilities modulate neural representations in children. This information is critical to understanding how attentional development shapes the way children process information
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Rule Abstraction Is Facilitated by Auditory Cuing in REM Sleep J. Neurosci. (IF 6.709) Pub Date : 2023-05-24 Sofia Isabel Ribeiro Pereira, Lorena Santamaria, Ralph Andrews, Elena Schmidt, Mark C.W. Van Rossum, Penelope Lewis
Sleep facilitates abstraction, but the exact mechanisms underpinning this are unknown. Here, we aimed to determine whether triggering reactivation in sleep could facilitate this process. We paired abstraction problems with sounds, then replayed these during either slow-wave sleep (SWS) or rapid eye movement (REM) sleep to trigger memory reactivation in 27 human participants (19 female). This revealed
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Development of BOLD Response to Motion in Human Infants J. Neurosci. (IF 6.709) Pub Date : 2023-05-24 Laura Biagi, Michela Tosetti, Sofia Allegra Crespi, Maria Concetta Morrone
Behavioral studies suggest that motion perception is rudimentary at birth and matures steadily over the first few years. We demonstrated previously that the major cortical associative areas serving motion processing, like middle temporal complex (MT+), visual cortex area 6 (V6), and PIVC in adults, show selective responses to coherent flow in 8-week-old infants. Here, we study the BOLD response to
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The SphK1/S1P Axis Regulates Synaptic Vesicle Endocytosis via TRPC5 Channels J. Neurosci. (IF 6.709) Pub Date : 2023-05-24 Zhong-Jiao Jiang, Liang-Wei Gong
Sphingosine-1-phosphate (S1P), a bioactive sphingolipid concentrated in the brain, is essential for normal brain functions, such as learning and memory and feeding behaviors. Sphingosine kinase 1 (SphK1), the primary kinase responsible for S1P production in the brain, is abundant within presynaptic terminals, indicating a potential role of the SphK1/S1P axis in presynaptic physiology. Altered S1P levels
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Multiple Subthreshold GPCR Signals Combined by the G-Proteins G{alpha}q and G{alpha}s Activate the Caenorhabditis elegans Egg-Laying Muscles J. Neurosci. (IF 6.709) Pub Date : 2023-05-24 Andrew C. Olson, Allison M. Butt, Nakeirah T.M. Christie, Ashish Shelar, Michael R. Koelle
Individual neurons or muscle cells express many G-protein-coupled receptors (GPCRs) for neurotransmitters and neuropeptides, yet it remains unclear how cells integrate multiple GPCR signals that all must activate the same few G-proteins. We analyzed this issue in the Caenorhabditis elegans egg-laying system, where multiple GPCRs on muscle cells promote contraction and egg laying. We genetically manipulated
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Toward an Interpersonal Neuroscience in Technologically Assisted (Virtual) Interactions. J. Neurosci. (IF 6.709) Pub Date : 2023-05-24 Kelong Lu,Yafeng Pan
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On the tonotopy of the low-frequency region of the cochlea. J. Neurosci. (IF 6.709) Pub Date : 2023-05-23 Alberto Recio-Spinoso,Wei Dong,John S Oghalai
It is generally assumed that frequency selectivity varies along the cochlea. For example, at the base of the cochlea, which is a region sensitive to high-frequency sounds, the best frequency of a cochlear location increases toward the most basal end, that is, near the stapes. Response phases also vary along cochlear locations: At any given frequency, there is a decrease in phase lag toward the stapes
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Decreased Thalamic Activity Is a Correlate for Disconnectedness During Anesthesia with Propofol, Dexmedetomidine and Sevoflurane but not S-Ketamine. J. Neurosci. (IF 6.709) Pub Date : 2023-05-23 Oskari Kantonen,Lauri Laaksonen,Michael Alkire,Annalotta Scheinin,Jaakko Långsjö,Roosa E Kallionpää,Kaike Kaisti,Linda Radek,Jarkko Johansson,Timo Laitio,Anu Maksimow,Joonas Scheinin,Mikko Nyman,Mika Scheinin,Olof Solin,Tero Vahlberg,Antti Revonsuo,Katja Valli,Harry Scheinin
Establishing the neural mechanisms responsible for the altered global states of consciousness during anesthesia and dissociating these from other drug-related effects remains a challenge in consciousness research. We investigated differences in brain activity between connectedness and disconnectedness by administering various anesthetics at concentrations designed to render 50% of the subjects unresponsive
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Auricular transcutaneous vagus nerve stimulation specifically enhances working memory gate closing mechanism - a system neurophysiological study. J. Neurosci. (IF 6.709) Pub Date : 2023-05-23 Anyla Konjusha,Shijing Yu,Moritz Mückschel,Lorenza Colzato,Tjalf Ziemssen,Christian Beste
Everyday tasks and goal-directed behavior involve the maintenance and continuous updating of information in working memory (WM). WM gating reflects switches between these two core states. Neurobiological considerations suggest that the catecholaminergic and the GABAergic are likely involved in these dynamics. Both of these neurotransmitter systems likely underly the effects to auricular transcutaneous
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Effect of aging and a dual orexin receptor antagonist on sleep architecture and NREM oscillations including a REM Behavior Disorder phenotype in the PS19 mouse model of tauopathy. J. Neurosci. (IF 6.709) Pub Date : 2023-05-22 Korey Kam,Kenny Vetter,Rachel A Tejiram,Ward D Pettibone,Kaitlyn Shim,Mickael Audrain,Liping Yu,Ilse S Daehn,Michelle E Ehrlich,Andrew W Varga
The impact of tau pathology on sleep microarchitecture features, including slow oscillations, spindles, and their coupling has been understudied, in spite of the proposed importance of these electrophysiological features toward learning and memory. Dual orexin receptor antagonists (DORAs) are known to promote sleep, but whether and how they affect sleep microarchitecture in the setting of tauopathy
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Ogt deficiency induces abnormal cerebellar function and behavioral deficits of adult mice through modulating RhoA/ROCK signaling. J. Neurosci. (IF 6.709) Pub Date : 2023-05-22 Jinyu Zhang,Kaiyan Wei,Wenzheng Qu,Mengxuan Wang,Qiang Zhu,Xiaoxue Dong,Xiaoli Huang,Wen Yi,Shunliang Xu,Xuekun Li
Previous studies have shown the essential roles of O-GlcNAc transferase (Ogt) and O-GlcNAcylation in neuronal development, function and neurological diseases. However, the function of Ogt and O-GlcNAcylation in the adult cerebellum has not been well elucidated. Here, we have found that cerebellum has the highest level of O-GlcNAcylation relative to cortex and hippocampus of adult male mice. Specific
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Insula dynorphin and kappa opioid receptor systems regulate alcohol drinking in a sex-specific manner in mice. J. Neurosci. (IF 6.709) Pub Date : 2023-05-22 Melanie M Pina,Dipanwita Pati,Sofia Neira,Lisa R Taxier,Christina M Stanhope,Alexandra A Mahoney,Shannon D'Ambrosio,Thomas L Kash,Montserrat Navarro
Alcohol use disorder is complex and multi-faceted, involving the coordination of multiple signaling systems across numerous brain regions. Previous work has indicated that both the insular cortex and dynorphin (DYN)/Kappa opioid receptor (KOR) systems contribute to excessive alcohol use. More recently, we identified a microcircuit in the medial aspect of the insular cortex that signals through DYN/KOR
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Delta-band neural responses to individual words are modulated by sentence processing. J. Neurosci. (IF 6.709) Pub Date : 2023-05-19 Sophie Slaats,Hugo Weissbart,Jan-Mathijs Schoffelen,Antje S Meyer,Andrea E Martin
To understand language, we need to recognize words and combine them into phrases and sentences. During this process, responses to the words themselves are changed. In a step towards understanding how the brain builds sentence structure, the present study concerns the neural readout of this adaptation. We ask whether low-frequency neural readouts associated with words change as a function of being in
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Cross-Platform Synaptic Network Analysis of Human Entorhinal Cortex Identifies TWF2 as a Modulator of Dendritic Spine Length J. Neurosci. (IF 6.709) Pub Date : 2023-05-17 Courtney K. Walker, Kelsey M. Greathouse, Jennifer J. Tuscher, Eric B. Dammer, Audrey J. Weber, Evan Liu, Kendall A. Curtis, Benjamin D. Boros, Cameron D. Freeman, Jung Vin Seo, Raksha Ramdas, Cheyenne Hurst, Duc M. Duong, Marla Gearing, Charles F. Murchison, Jeremy J. Day, Nicholas T. Seyfried, Jeremy H. Herskowitz
Proteomic studies using postmortem human brain tissue samples have yielded robust assessments of the aging and neurodegenerative disease(s) proteomes. While these analyses provide lists of molecular alterations in human conditions, like Alzheimer's disease (AD), identifying individual proteins that affect biological processes remains a challenge. To complicate matters, protein targets may be highly
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Axonal ER Ca2+ Release Selectively Enhances Activity-Independent Glutamate Release in a Huntington Disease Model J. Neurosci. (IF 6.709) Pub Date : 2023-05-17 James P. Mackay, Amy I. Smith-Dijak, Ellen T. Koch, Peng Zhang, Evan Fung, Wissam B. Nassrallah, Caodu Buren, Mandi Schmidt, Michael R. Hayden, Lynn A. Raymond
Action potential (AP)-independent (miniature) neurotransmission occurs at all chemical synapses but remains poorly understood, particularly in pathologic contexts. Axonal endoplasmic reticulum (ER) Ca2+ stores are thought to influence miniature neurotransmission, and aberrant ER Ca2+ handling is implicated in progression of Huntington disease (HD). Here, we report elevated mEPSC frequencies in recordings
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Conceptual Associations Generate Sensory Predictions J. Neurosci. (IF 6.709) Pub Date : 2023-05-17 Chuyao Yan, Floris P. de Lange, David Richter
A crucial ability of the human brain is to learn and exploit probabilistic associations between stimuli to facilitate perception and behavior by predicting future events. Although studies have shown how perceptual relationships are used to predict sensory inputs, relational knowledge is often between concepts rather than percepts (e.g., we learned to associate cats with dogs, rather than specific images
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Naturalistic Spoken Language Comprehension Is Supported by Alpha and Beta Oscillations J. Neurosci. (IF 6.709) Pub Date : 2023-05-17 Ioanna Zioga, Hugo Weissbart, Ashley G. Lewis, Saskia Haegens, Andrea E. Martin
Brain oscillations are prevalent in all species and are involved in numerous perceptual operations. α oscillations are thought to facilitate processing through the inhibition of task-irrelevant networks, while β oscillations are linked to the putative reactivation of content representations. Can the proposed functional role of α and β oscillations be generalized from low-level operations to higher-level
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Functional Segregation of the Human Cerebellum in Social Cognitive Tasks Revealed by TMS J. Neurosci. (IF 6.709) Pub Date : 2023-05-17 Chiara Ferrari, Andrea Ciricugno, Maria Arioli, Zaira Cattaneo
The role of the posterior cerebellum in social cognition is well established; however, it is still unclear whether different cerebellar subregions contribute to different social cognitive processes by exerting specific functions. Here, we employed transcranial magnetic stimulation (TMS) in male and female healthy humans to test the hypothesis of the existence of a medial-to-lateral gradient in the
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Intrinsic Neural Timescales in the Temporal Lobe Support an Auditory Processing Hierarchy J. Neurosci. (IF 6.709) Pub Date : 2023-05-17 Riccardo Cusinato, Sigurd L. Alnes, Ellen van Maren, Ida Boccalaro, Debora Ledergerber, Antoine Adamantidis, Lukas L. Imbach, Kaspar Schindler, Maxime O. Baud, Athina Tzovara
During rest, intrinsic neural dynamics manifest at multiple timescales, which progressively increase along visual and somatosensory hierarchies. Theoretically, intrinsic timescales are thought to facilitate processing of external stimuli at multiple stages. However, direct links between timescales at rest and sensory processing, as well as translation to the auditory system are lacking. Here, we measured
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Sensitivity to Frequency Modulation is Limited Centrally J. Neurosci. (IF 6.709) Pub Date : 2023-05-17 Kelly L. Whiteford, Andrew J. Oxenham
Modulations in both amplitude and frequency are prevalent in natural sounds and are critical in defining their properties. Humans are exquisitely sensitive to frequency modulation (FM) at the slow modulation rates and low carrier frequencies that are common in speech and music. This enhanced sensitivity to slow-rate and low-frequency FM has been widely believed to reflect precise, stimulus-driven phase
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The Self-Concept Is Represented in the Medial Prefrontal Cortex in Terms of Self-Importance J. Neurosci. (IF 6.709) Pub Date : 2023-05-17 Marie Levorsen, Ryuta Aoki, Kenji Matsumoto, Constantine Sedikides, Keise Izuma
Knowledge about one's personality, the self-concept, shapes human experience. Social cognitive neuroscience has made strides addressing the question of where and how the self is represented in the brain. The answer, however, remains elusive. We conducted two functional magnetic resonance imaging experiments (the second preregistered) with human male and female participants employing a self-reference
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Alternative Brain Connectivity Underscores Age-Related Differences in the Processing of Interactive Biological Motion J. Neurosci. (IF 6.709) Pub Date : 2023-05-17 Jon Walbrin, Jorge Almeida, Kami Koldewyn
Rapidly recognizing and understanding others' social interactions is an important ability that relies on deciphering multiple sources of information, for example, perceiving body information and inferring others' intentions. Despite recent advances in characterizing the brain basis of this ability in adults, its developmental underpinnings are virtually unknown. Here, we used fMRI to investigate which
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The Representational Similarity between Visual Perception and Recent Perceptual History J. Neurosci. (IF 6.709) Pub Date : 2023-05-17 Junlian Luo, Thérèse Collins
From moment to moment, the visual properties of objects in the world fluctuate because of external factors like ambient lighting, occlusion and eye movements, and internal (proximal) noise. Despite this variability in the incoming information, our perception is stable. Serial dependence, the behavioral attraction of current perceptual responses toward previously seen stimuli, may reveal a mechanism
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Coordination of Locomotion by Serotonergic Neurons in the Predatory Gastropod Pleurobranchaea californica J. Neurosci. (IF 6.709) Pub Date : 2023-05-17 Colin A. Lee, Jeffrey W. Brown, Rhanor Gillette
Similar design characterizes neuronal networks for goal-directed motor control across the complex, segmented vertebrates, insects, and polychaete annelids with jointed appendages. Evidence is lacking for whether this design evolved independently in those lineages, evolved in parallel with segmentation and appendages, or could have been present in a soft-bodied common ancestor. We examined coordination
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Paraventricular Thalamus Dynamically Modulates Aversive Memory via Tuning Prefrontal Inhibitory Circuitry J. Neurosci. (IF 6.709) Pub Date : 2023-05-17 Tianyu Wang, Rongzhen Yan, Xinyang Zhang, Zongliang Wang, Haoyu Duan, Zeyi Wang, Qiang Zhou
The impact of stress on the formation and expression of memory is well studied, especially on the contributions of stress hormones. But how stress affects brain circuitry dynamically to modulate memory is far less understood. Here, we used male C57BL6/J mice in an auditory fear conditioning as a model system to examine this question and focused on the impact of stress on dorsomedial prefrontal cortex
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Transferrin Receptor Is Necessary for Proper Oligodendrocyte Iron Homeostasis and Development J. Neurosci. (IF 6.709) Pub Date : 2023-05-17 Veronica T. Cheli, Diara A. Santiago González, Rensheng Wan, Shaina L. Rosenblum, Giancarlo E. Denaroso, Christina G. Angeliu, Zachary Smith, Congying Wang, Pablo M. Paez
To test the hypothesis that the transferrin (Tf) cycle has unique importance for oligodendrocyte development and function, we disrupted the expression of the Tf receptor (Tfr) gene in oligodendrocyte progenitor cells (OPCs) on mice of either sex using the Cre/lox system. This ablation results in the elimination of iron incorporation via the Tf cycle but leaves other Tf functions intact. Mice lacking
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Connecting Connectomes to Physiology J. Neurosci. (IF 6.709) Pub Date : 2023-05-17 Alexander Borst, Christian Leibold
With the advent of volumetric EM techniques, large connectomic datasets are being created, providing neuroscience researchers with knowledge about the full connectivity of neural circuits under study. This allows for numerical simulation of detailed, biophysical models of each neuron participating in the circuit. However, these models typically include a large number of parameters, and insight into
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Abstract value encoding in neural populations but not single neurons. J. Neurosci. (IF 6.709) Pub Date : 2023-05-17 Justin M Fine,David J-N Maisson,Seng Bum Michael Yoo,Tyler V Cash-Padgett,Maya Zhe Wang,Jan Zimmermann,Benjamin Y Hayden
An important open question in neuroeconomics is how the brain represents the value of offers in a way that is both abstract (allowing for comparison) and concrete (preserving the details of the factors that influence value). Here we examine neuronal responses to risky and safe options in five brain regions that putatively encode value in male macaques. Surprisingly, we find no detectable overlap in
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LIGHT ADAPTATION OF RETINAL ROD BIPOLAR CELLS. J. Neurosci. (IF 6.709) Pub Date : 2023-05-17 Khris G Griffis,Katherine E Fehlhaber,Fred Rieke,Alapakkam P Sampath
The sensitivity of retinal cells is altered in background light to optimize the detection of contrast. For scotopic (rod) vision, substantial adaptation occurs in the first two cells, the rods and rod bipolar cells (RBCs), through sensitivity adjustments in rods and postsynaptic modulation of the transduction cascade in RBCs. To study the mechanisms mediating these components of adaptation, we made
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Fast and Slow Rhythms of Naturalistic Reading Revealed by Combined Eye-Tracking and Electroencephalography. J. Neurosci. (IF 6.709) Pub Date : 2023-05-17 Lena Henke,Ashley G Lewis,Lars Meyer
Neural oscillations are thought to support speech and language processing. They may not only inherit acoustic rhythms, but might also impose endogenous rhythms onto processing. In support of this, we here report that human (both, male and female) eye movements during naturalistic reading exhibit rhythmic patterns that show frequency-selective coherence with the electroencephalogram (EEG)-in the absence
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Elevated galectin-3 is associated with aging, multiple sclerosis, and oxidized phosphatidylcholine induced neurodegeneration. J. Neurosci. (IF 6.709) Pub Date : 2023-05-17 Sara Xue,Brian M Lozinski,Samira Ghorbani,Khanh Ta,Charlotte D'Mello,V Wee Yong,Yifei Dong
Aging is a significant risk factor associated with the progression of central nervous system (CNS) neurodegenerative diseases including multiple sclerosis (MS). Microglia, the resident macrophages of the CNS parenchyma, are a major population of immune cells that accumulate in MS lesions. While they normally regulate tissue homeostasis and facilitate the clearance of neurotoxic molecules including
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Complex Interactions between Distinct Theta Oscillatory Patterns during Sleep Deprivation. J. Neurosci. (IF 6.709) Pub Date : 2023-05-17 Jing Jun Wong,Victor K S Chan,Melody M Y Chan
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Fast-spiking interneurons of the premotor cortex contribute to initiation and execution of spontaneous actions. J. Neurosci. (IF 6.709) Pub Date : 2023-05-16 Nadia Giordano,Claudia Alia,Lorenzo Fruzzetti,Maria Pasquini,Giulia Palla,Alberto Mazzoni,Silvestro Micera,Leonardo Fogassi,Luca Bonini,Matteo Caleo
Planning and execution of voluntary movement depend on the contribution of distinct classes of neurons in primary motor and premotor areas. However, timing and pattern of activation of GABAergic cells during specific motor behaviors remain only partly understood. Here, we directly compared the response properties of putative pyramidal neurons (PNs) and GABAergic fast-spiking neurons (FSNs) during spontaneous
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Language exposure and brain myelination in early development. J. Neurosci. (IF 6.709) Pub Date : 2023-05-15 Laia Fibla,Samuel H Forbes,Jordan McCarthy,Kate Mee,Vincent Magnotta,Sean Deoni,Donnie Cameron,John P Spencer
The language environment to which children are exposed has an impact on later language abilities as well as on brain development; however, it is unclear how early such impacts emerge. This study investigates the effects of children's early language environment and socioeconomic status (SES) on brain structure in infancy at 6 and 30 months of age (both sexes included). We used magnetic resonance imaging
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Disinhibition of mesolimbic dopamine circuit by the lateral hypothalamus regulates pain sensation. J. Neurosci. (IF 6.709) Pub Date : 2023-05-15 Yu Ma,Weinan Zhao,Dandan Chen,Dongyu Zhou,Yihong Gao,Yixin Bian,Yuqing Xu,Sun-Hui Xia,Tantan Fang,Jun-Xia Yang,Lingzhen Song,He Liu,Hai-Lei Ding,Hongxing Zhang,Jun-Li Cao
Our recent study demonstrated the critical role of the mesolimbic dopamine (DA) circuit and its brain-derived neurotropic factor (BDNF) signaling in mediating neuropathic pain. The present study aims to investigate the functional role of GABA-ergic inputs from the lateral hypothalamus to the ventral tegmental area (LHGABA→VTA) in regulating the mesolimbic DA circuit and its BDNF signaling underlying
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ADAMTS-4 enhances oligodendrocyte differentiation and remyelination by cleaving NG2 proteoglycan and attenuating PDGFRα signaling. J. Neurosci. (IF 6.709) Pub Date : 2023-05-12 Chunxia Jiang,Wanwan Qiu,Yingying Yang,Hao Huang,Zhongmin Dai,Aifen Yang,Tao Tang,Xiaofeng Zhao,Mengsheng Qiu
Although NG2 is known to be selectively expressed in oligodendrocyte precursor cells (OPCs) for many years, its expressional regulation and functional involvement in oligodendrocyte differentiation have remained elusive. Here, we report that the surface-bound NG2 proteoglycan can physically bind to PDGF-AA and enhances PDGFRα activation of downstream signaling. During differentiation stage, NG2 protein
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Cellular Diversity in Human Subgenual Anterior Cingulate and Dorsolateral Prefrontal Cortex by Single-Nucleus RNA-Sequencing J. Neurosci. (IF 6.709) Pub Date : 2023-05-10 Billy Kim, Dowon Kim, Anton Schulmann, Yash Patel, Carolina Caban-Rivera, Paul Kim, Ananya Jambhale, Kory R. Johnson, Ningping Feng, Qing Xu, Sun Jung Kang, Ajeet Mandal, Michael Kelly, Nirmala Akula, Francis J. McMahon, Barbara Lipska, Stefano Marenco, Pavan K. Auluck
Regional cellular heterogeneity is a fundamental feature of the human neocortex; however, details of this heterogeneity are still undefined. We used single-nucleus RNA-sequencing to examine cell-specific transcriptional features in the dorsolateral PFC (DLPFC) and the subgenual anterior cingulate cortex (sgACC), regions implicated in major psychiatric disorders. Droplet-based nuclei-capture and library
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Single Systemic Administration of a Gene Therapy Leading to Disease Treatment in Metachromatic Leukodystrophy Arsa Knock-Out Mice J. Neurosci. (IF 6.709) Pub Date : 2023-05-10 Thia St. Martin, Tania A. Seabrook, Katherine Gall, Jenn Newman, Nancy Avila, April Hayes, Monicah Kivaa, Jason Lotterhand, Michael Mercaldi, Kruti Patel, Israel J. Rivas, Stephen Woodcock, Teresa L. Wright, Albert B. Seymour, Omar L. Francone, Jacinthe Gingras
Metachromatic leukodystrophy (MLD) is a rare, inherited, demyelinating lysosomal storage disorder caused by mutations in the arylsulfatase-A gene (ARSA). In patients, levels of functional ARSA enzyme are diminished and lead to deleterious accumulation of sulfatides. Herein, we demonstrate that intravenous administration of HSC15/ARSA restored the endogenous murine biodistribution of the corresponding
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Poorer White Matter Microstructure Predicts Slower and More Variable Reaction Time Performance: Evidence for a Neural Noise Hypothesis in a Large Lifespan Cohort J. Neurosci. (IF 6.709) Pub Date : 2023-05-10 Ethan M. McCormick, Cambridge Centre for Ageing and Neuroscience, Rogier A. Kievit
Most prior research has focused on characterizing averages in cognition, brain characteristics, or behavior, and attempting to predict differences in these averages among individuals. However, this overwhelming focus on mean levels may leave us with an incomplete picture of what drives individual differences in behavioral phenotypes by ignoring the variability of behavior around an individual's mean
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Two Oscillatory Correlates of Attention Control in the Alpha-Band with Distinct Consequences on Perceptual Gain and Metacognition J. Neurosci. (IF 6.709) Pub Date : 2023-05-10 Jelena Trajkovic, Francesco Di Gregorio, Alessio Avenanti, Gregor Thut, Vincenzo Romei
Behavioral consequences and neural underpinnings of visuospatial attention have long been investigated. Classical studies using the Posner paradigm have found that visual perception systematically benefits from the use of a spatially informative cue pointing to the to-be-attended spatial location, compared with a noninformative cue. Lateralized α amplitude modulation during visuospatial attention shifts
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A Learned Map for Places and Concepts in the Human Medial Temporal Lobe J. Neurosci. (IF 6.709) Pub Date : 2023-05-10 Nora A. Herweg, Lukas Kunz, Daniel Schonhaut, Armin Brandt, Paul A. Wanda, Ashwini D. Sharan, Michael R. Sperling, Andreas Schulze-Bonhage, Michael J. Kahana
Distinct lines of research in both humans and animals point to a specific role of the hippocampus in both spatial and episodic memory function. The discovery of concept cells in the hippocampus and surrounding medial temporal lobe (MTL) regions suggests that the MTL maps physical and semantic spaces with a similar neural architecture. Here, we studied the emergence of such maps using MTL microwire
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Changes in Resting State Functional Connectivity Associated with Dynamic Adaptation of Wrist Movements J. Neurosci. (IF 6.709) Pub Date : 2023-05-10 Andria J. Farrens, Shahabeddin Vahdat, Fabrizio Sergi
Dynamic adaptation is an error-driven process of adjusting planned motor actions to changes in task dynamics (Shadmehr, 2017). Adapted motor plans are consolidated into memories that contribute to better performance on re-exposure. Consolidation begins within 15 min following training (Criscimagna-Hemminger and Shadmehr, 2008), and can be measured via changes in resting state functional connectivity
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Accelerating Maturation of Spatial Memory Systems by Experience: Evidence from Sleep Oscillation Signatures of Memory Processing J. Neurosci. (IF 6.709) Pub Date : 2023-05-10 María P. Contreras, Julia Fechner, Jan Born, Marion Inostroza
During early development, memory systems gradually mature over time, in parallel with the gradual accumulation of knowledge. Yet, it is unknown whether and to what extent maturation is driven by discrete experience. Sleep is thought to contribute to the formation of long-term memory and knowledge through a systems consolidation process that is driven by specific sleep oscillations (i.e., ripples, spindles
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Impact of Acute Visual Experience on Development of LGN Receptive Fields in the Ferret J. Neurosci. (IF 6.709) Pub Date : 2023-05-10 Andrea K. Stacy, Nathan A. Schneider, Noah K. Gilman, Stephen D. Van Hooser
Selectivity for direction of motion is a key feature of primary visual cortical neurons. Visual experience is required for direction selectivity in carnivore and primate visual cortex, but the circuit mechanisms of its formation remain incompletely understood. Here, we examined how developing lateral geniculate nucleus (LGN) neurons may contribute to cortical direction selectivity. Using in vivo electrophysiology
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Face-Selective Patches in Marmosets Are Involved in Dynamic and Static Facial Expression Processing J. Neurosci. (IF 6.709) Pub Date : 2023-05-10 Audrey Dureux, Alessandro Zanini, Stefan Everling
The correct identification of facial expressions is critical for understanding the intention of others during social communication in the daily life of all primates. Here we used ultra-high-field fMRI at 9.4 T to investigate the neural network activated by facial expressions in awake New World common marmosets from both male and female sex, and to determine the effect of facial motions on this network
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The 3D Structural Architecture of the Human Hand Area Is Nontopographic J. Neurosci. (IF 6.709) Pub Date : 2023-05-10 Juliane Doehler, Alicia Northall, Peng Liu, Alessio Fracasso, Anastasia Chrysidou, Oliver Speck, Gabriele Lohmann, Thomas Wolbers, Esther Kuehn
The functional topography of the human primary somatosensory cortex hand area is a widely studied model system to understand sensory organization and plasticity. It is so far unclear whether the underlying 3D structural architecture also shows a topographic organization. We used 7 Tesla (7T) magnetic resonance imaging (MRI) data to quantify layer-specific myelin, iron, and mineralization in relation
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Interleukin (IL)-1 Receptor Signaling Is Required for Complete Taste Bud Regeneration and the Recovery of Neural Taste Responses following Axotomy J. Neurosci. (IF 6.709) Pub Date : 2023-05-10 Guangkuo Dong, Schuyler Kogan, Natasha Venugopal, Eddy Chang, Lianying He, Fama Faal, Yang Shi, Lynnette Phillips McCluskey
Experimental or traumatic nerve injury causes the degeneration of associated taste buds. Unlike most sensory systems, the sectioned nerve and associated taste buds can then regenerate, restoring neural responses to tastants. It was previously unknown whether injury-induced immune factors mediate this process. The proinflammatory cytokines, interleukin (IL)-1α and IL-1β, and their requisite receptor
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Mitofusin 2 Sustains the Axonal Mitochondrial Network to Support Presynaptic Ca2+ Homeostasis and the Synaptic Vesicle Cycle in Rat Hippocampal Axons J. Neurosci. (IF 6.709) Pub Date : 2023-05-10 Jason D. Vevea, Edwin R. Chapman
Mitochondria exert powerful control over cellular physiology, contributing to ion homeostasis, energy production, and metabolite biosynthesis. The trafficking and function of these organelles are particularly important in neurons, with impaired mitochondrial function or altered morphology observed in every neurodegenerative disorder studied. While mitochondrial biosynthetic products play a crucial
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Drosophila Tachykininergic Neurons Modulate the Activity of Two Groups of Receptor-Expressing Neurons to Regulate Aggressive Tone J. Neurosci. (IF 6.709) Pub Date : 2023-05-10 Margot P. Wohl, Jett Liu, Kenta Asahina
Neuropeptides influence animal behaviors through complex molecular and cellular mechanisms, the physiological and behavioral effects of which are difficult to predict solely from synaptic connectivity. Many neuropeptides can activate multiple receptors, whose ligand affinity and downstream signaling cascades are often different from one another. Although we know that the diverse pharmacological characteristics