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Structural basis of λCII-dependent transcription activation Structure (IF 5.871) Pub Date : 2023-06-02 Minxing Zhao, Bo Gao, Aijia Wen, Yu Feng, Yuan-Qiang Lu
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Discovery and characterization of cyclic peptides selective for the C-terminal bromodomains of BET family proteins Structure (IF 5.871) Pub Date : 2023-06-02 Charlotte Franck, Karishma Patel, Louise J. Walport, Mary Christie, Alexander Norman, Toby Passioura, Hiroaki Suga, Richard J. Payne, Joel P. Mackay
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Phosphorylation at Ser65 modulates ubiquitin conformational dynamics Structure (IF 5.871) Pub Date : 2023-06-01 Remy A. Yovanno, Alvin Yu, Tyler J. Wied, Albert Y. Lau
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α-carboxysomes present a multi-layered structural challenge Structure (IF 5.871) Pub Date : 2023-06-01 Matthew S. Kimber
α-carboxysomes are large, heterogeneous bodies that fix CO2 in cyanobacteria. In this issue of Structure, Evans et al. (2023) report a cryo-electron microscopy study of the α-carboxysome from Cyanobium sp. PCC 7001 along with modeling of its icosahedral shell and the packing of RuBisCO within its interior.
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Mind the gap Structure (IF 5.871) Pub Date : 2023-06-01 Sven Larsen-Ledet, Amelie Stein
Amino acid deletions are high-risk, high-reward mutations, yet structural consequences are poorly understood. In this issue of Structure, Woods et al. (2023) individually deleted 65 residues from a small α-helical protein, structurally assayed the 17 soluble variants, and developed a computational model of deletion solubility combining Rosetta and AlphaFold2.
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Residue-level error detection in cryoelectron microscopy models Structure (IF 5.871) Pub Date : 2023-05-29 Gabriella Reggiano, Wolfgang Lugmayr, Daniel Farrell, Thomas C. Marlovits, Frank DiMaio
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Crystal structure of Escherichia coli thiamine pyrophosphate-sensing riboswitch in the apo state Structure (IF 5.871) Pub Date : 2023-05-29 Hyun Kyung Lee, Yun-Tzai Lee, Lixin Fan, Haley M. Wilt, Chelsie E. Conrad, Ping Yu, Jinwei Zhang, Genbin Shi, Xinhua Ji, Yun-Xing Wang, Jason R. Stagno
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Dual mechanisms of cholesterol-GPCR interactions that depend on membrane phospholipid composition Structure (IF 5.871) Pub Date : 2023-05-25 Arka Prabha Ray, Naveen Thakur, Niloofar Gopal Pour, Matthew T. Eddy
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Redox switching mechanism of the adenosine 5′-phosphosulfate kinase domain (APSK2) of human PAPS synthase 2 Structure (IF 5.871) Pub Date : 2023-05-18 Lin Zhang, Wenyan Song, Tingting Li, Yajuan Mu, Pan Zhang, Jingyan Hu, Houwen Lin, Jian Zhang, Hai Gao, Liang Zhang
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Structural basis for different membrane-binding properties of E. coli anaerobic and human mitochondrial β-oxidation trifunctional enzymes Structure (IF 5.871) Pub Date : 2023-05-15 Shiv K. Sah-Teli, Matyas Pinkas, Mikko J. Hynönen, Sarah J. Butcher, Rik K. Wierenga, Jiri Novacek, Rajaram Venkatesan
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Allosteric modulation of ryanodine receptor RyR1 by nucleotide derivatives Structure (IF 5.871) Pub Date : 2023-05-15 Spencer Cholak, James W. Saville, Xing Zhu, Alison M. Berezuk, Katharine S. Tuttle, Omid Haji-Ghassemi, Francisco J. Alvarado, Filip Van Petegem, Sriram Subramaniam
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Molecular basis of SARS-CoV-2 Omicron variant evasion from shared neutralizing antibody response Structure (IF 5.871) Pub Date : 2023-05-11 Anamika Patel, Sanjeev Kumar, Lilin Lai, Chennareddy Chakravarthy, Rajesh Valanparambil, Elluri Seetharami Reddy, Kamalvishnu Gottimukkala, Prashant Bajpai, Dinesh Ravindra Raju, Venkata Viswanadh Edara, Meredith E. Davis-Gardner, Susanne Linderman, Kritika Dixit, Pragati Sharma, Grace Mantus, Narayanaiah Cheedarla, Hans P. Verkerke, Filipp Frank, Andrew S. Neish, John D. Roback, Eric A. Ortlund
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Structural insights into DarT toxin neutralization by cognate DarG antitoxin: ssDNA mimicry by DarG C-terminal domain keeps the DarT toxin inhibited Structure (IF 5.871) Pub Date : 2023-05-10 Amar Deep, Latika Singh, Japleen Kaur, Maheshwaran Velusamy, Pushpanjali Bhardwaj, Ramandeep Singh, Krishan Gopal Thakur
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Structure-based prediction of Ras-effector binding affinities and design of “branchegetic” interface mutations Structure (IF 5.871) Pub Date : 2023-05-10 Philipp Junk, Christina Kiel
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Tails don’t tell the whole story Structure (IF 5.871) Pub Date : 2023-05-04 Mikel Garcia-Marcos
Before engaging G protein-coupled receptors (GPCRs) to transduce extracellular signals, heterotrimeric G proteins (Gαβγ) must fold properly with the help of chaperones. In this issue of Structure, Papasergi-Scott et al. (2023) unveil the molecular basis for how mammalian Ric-8 chaperones achieve selectivity for their respective Gα subunit clients.
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O-methyltransferases selectively modify anthraquinone natural products Structure (IF 5.871) Pub Date : 2023-05-04 Zhiyang Feng
In this issue of Structure, Huber et al. identify five O-methyltransferases, and three of them catalyze the sequential methylation of the Gram-negative bacterium-derived aromatic polyketide anthraquinone AQ-256. They present co-crystal structures with bound AQ-256 and its methylated derivatives, which explains the specificities of these O-methyltransferases.
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Shining light on the chloroplast protein import machinery of plants Structure (IF 5.871) Pub Date : 2023-05-04 Venkatasalam Shanmugabalaji, Felix Kessler
Sunny days for chloroplast protein import: Srinivasan et al. (2023) report on the isolation and provide the first structural information on the pea TOC complex that mediates protein translocation across the outer chloroplast membrane. While two cryoEM structures for algal import complexes have been published, this is the gateway to long-sought-after structures from land plants.
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Molecular insights into peptide agonist engagement with the PTH receptor Structure (IF 5.871) Pub Date : 2023-05-05 Brian P. Cary, Elliot J. Gerrard, Matthew J. Belousoff, Madeleine M. Fletcher, Yan Jiang, Isabella C. Russell, Sarah J. Piper, Denise Wootten, Patrick M. Sexton
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Structural characterization of human tryptophan hydroxylase 2 reveals that L-Phe is superior to L-Trp as the regulatory domain ligand Structure (IF 5.871) Pub Date : 2023-04-28 Ida M. Vedel, Andreas Prestel, Zhenwei Zhang, Natalia T. Skawinska, Holger Stark, Pernille Harris, Birthe B. Kragelund, Günther H.J. Peters
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Computational modeling and prediction of deletion mutants Structure (IF 5.871) Pub Date : 2023-04-28 Hope Woods, Dominic L. Schiano, Jonathan I. Aguirre, Kaitlyn V. Ledwitch, Eli F. McDonald, Markus Voehler, Jens Meiler, Clara T. Schoeder
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Multi-site-specific isotopic labeling accelerates high-resolution structural investigations of pathogenic huntingtin exon-1 Structure (IF 5.871) Pub Date : 2023-04-28 Carlos A. Elena-Real, Annika Urbanek, Xamuel L. Lund, Anna Morató, Amin Sagar, Aurélie Fournet, Alejandro Estaña, Tracy Bellande, Frédéric Allemand, Juan Cortés, Nathalie Sibille, Ronald Melki, Pau Bernadó
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Transmembrane dimers of type 1 receptors sample alternate configurations: MD simulations using coarse grain Martini 3 versus AlphaFold2 Multimer Structure (IF 5.871) Pub Date : 2023-04-18 Amita R. Sahoo, Paulo C.T. Souza, Zhiyuan Meng, Matthias Buck
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Desensitization dynamics of the AMPA receptor Structure (IF 5.871) Pub Date : 2023-04-13 Jussi Aittoniemi, Morten Ø. Jensen, Albert C. Pan, David E. Shaw
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Architecture of a PKS-NRPS hybrid megaenzyme involved in the biosynthesis of the genotoxin colibactin Structure (IF 5.871) Pub Date : 2023-04-13 Sarah Bonhomme, Carlos Contreras-Martel, Andréa Dessen, Pauline Macheboeuf
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Structure of the human UBR5 E3 ubiquitin ligase Structure (IF 5.871) Pub Date : 2023-04-10 Feng Wang, Qing He, Wenhu Zhan, Ziqi Yu, Efrat Finkin-Groner, Xiaojing Ma, Gang Lin, Huilin Li
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Structure of Anabaena flos-aquae gas vesicles revealed by cryo-ET Structure (IF 5.871) Pub Date : 2023-04-10 Przemysław Dutka, Lauren Ann Metskas, Robert C. Hurt, Hossein Salahshoor, Ting-Yu Wang, Dina Malounda, George J. Lu, Tsui-Fen Chou, Mikhail G. Shapiro, Grant J. Jensen
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We con-dense if we want to; We can’t leave AZUL outside Structure (IF 5.871) Pub Date : 2023-04-06 Thuy P. Dao, Carlos A. Castañeda
In this issue of Structure, Buel et al. (2023) combined NMR data with AlphaFold2 to map out the interaction between the AZUL domain of ubiquitin ligase E6AP and UBQLN1/2 UBA. The authors demonstrated that this interaction enhances the self-association of the helix neighboring UBA and enables E6AP to localize to UBQLN2 droplets.
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Two heads are better than one: Cooperation of two CAPS domains in membrane binding Structure (IF 5.871) Pub Date : 2023-04-06 Gang Dong
In this issue of Structure, Zhang et al. report their structural studies on the C2 and PH domains of Ca2+-dependent activator proteins for secretion (CAPS). The two domains form a tightly packed module and generate a continuous basic patch across both domains to substantially enhance CAPS binding to PI(4,5)P2-containing membranes.
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Cryo-EM-based structural insights into supramolecular assemblies of γ-hemolysin from S. aureus reveal the pore formation mechanism Structure (IF 5.871) Pub Date : 2023-04-04 Suman Mishra, Anupam Roy, Somnath Dutta
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Single-particle cryo-EM analysis of the shell architecture and internal organization of an intact α-carboxysome Structure (IF 5.871) Pub Date : 2023-04-03 Sasha L. Evans, Monsour M.J. Al-Hazeem, Daniel Mann, Nicolas Smetacek, Andrew J. Beavil, Yaqi Sun, Taiyu Chen, Gregory F. Dykes, Lu-Ning Liu, Julien R.C. Bergeron
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Three structural solutions for bacterial adhesion pilus stability and superelasticity Structure (IF 5.871) Pub Date : 2023-03-30 Matthew H. Doran, Joseph L. Baker, Tobias Dahlberg, Magnus Andersson, Esther Bullitt
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Molecular insight into the PCNA-binding mode of FBH1 Structure (IF 5.871) Pub Date : 2023-03-28 Jiuyang Liu, Belén Chaves-Arquero, Pengcheng Wei, Adam H. Tencer, Antonio Ruiz-Albor, Gongyi Zhang, Francisco J. Blanco, Tatiana G. Kutateladze
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Structural features of the Notch ankyrin domain-Deltex WWE2 domain heterodimer determined by NMR spectroscopy and functional implications Structure (IF 5.871) Pub Date : 2023-03-27 Andrea A. Carter, Kristen M. Ramsey, Christine L. Hatem, Kathryn P. Sherry, Ananya Majumdar, Doug Barrick
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Characterization of synthetic antigen binding fragments targeting Toc75 for the isolation of TOC in A. thaliana and P. sativum Structure (IF 5.871) Pub Date : 2023-03-27 Karthik Srinivasan, Satchal K. Erramilli, Srinivas Chakravarthy, Adrian Gonzalez, Anthony Kossiakoff, Nicholas Noinaj
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Structural insights into the regulation of peptidoglycan DL-endopeptidases by inhibitory protein IseA Structure (IF 5.871) Pub Date : 2023-03-23 Sudarshan Tandukar, Eunju Kwon, Dong Young Kim
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A set of closely related methyltransferases for site-specific tailoring of anthraquinone pigments Structure (IF 5.871) Pub Date : 2023-03-23 Eva M. Huber, Lukas Kreling, Antje K. Heinrich, Maximilian Dünnebacke, Alexander Pöthig, Helge B. Bode, Michael Groll
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Characterization of the mechanism of bile salt hydrolase substrate specificity by experimental and computational analyses Structure (IF 5.871) Pub Date : 2023-03-23 Dmitry S. Karlov, Sarah L. Long, Ximin Zeng, Fuzhou Xu, Kanhaya Lal, Liu Cao, Karim Hayoun, Jun Lin, Susan A. Joyce, Irina G. Tikhonova
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Cooperative mechanics of PR65 scaffold underlies the allosteric regulation of the phosphatase PP2A Structure (IF 5.871) Pub Date : 2023-03-21 Burak T. Kaynak, Zakaria L. Dahmani, Pemra Doruker, Anupam Banerjee, Shang-Hua Yang, Reuven Gordon, Laura S. Itzhaki, Ivet Bahar
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Cryo-EM structures of anti-malarial antibody L9 with circumsporozoite protein reveal trimeric L9 association and complete 27-residue epitope Structure (IF 5.871) Pub Date : 2023-03-16 Prabhanshu Tripathi, Michael F. Bender, Haotian Lei, Lais Da Silva Pereira, Chen-Hsiang Shen, Brian Bonilla, Marlon Dillon, Li Ou, Marie Pancera, Lawrence T. Wang, Baoshan Zhang, Facundo D. Batista, Azza H. Idris, Robert A. Seder, Peter D. Kwong
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Structures of Ric-8B in complex with Gα protein folding clients reveal isoform specificity mechanisms Structure (IF 5.871) Pub Date : 2023-03-16 Makaía M. Papasergi-Scott, Frank E. Kwarcinski, Maiya Yu, Ouliana Panova, Ann M. Ovrutsky, Georgios Skiniotis, Gregory G. Tall
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Heterocomplex structure of a polyketide synthase component involved in modular backbone halogenation Structure (IF 5.871) Pub Date : 2023-03-13 Amy E. Fraley, Maria Dell, Maximilian Schmalhofer, Roy A. Meoded, Cedric Bergande, Michael Groll, Jörn Piel
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Structure and interactions of the phloem lectin (phloem protein 2) Cus17 from Cucumis sativus Structure (IF 5.871) Pub Date : 2023-03-06 Kishore Babu Bobbili, Nukathoti Sivaji, Badma Priya, Kaza Suguna, Avadhesha Surolia
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A snapshot of the aryl hydrocarbon receptor complex Structure (IF 5.871) Pub Date : 2023-03-02 Mohinder Pal
In this issue of Structure, Wen et al. present the cryo-EM structure of the aryl hydrocarbon receptor (AhR) and show how it is recruited and stabilized by the HSP90 molecular chaperone and its co-chaperones XAP2 and p23.
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Molecular architecture and dynamics of SARS-CoV-2 envelope by integrative modeling Structure (IF 5.871) Pub Date : 2023-03-03 Weria Pezeshkian, Fabian Grünewald, Oleksandr Narykov, Senbao Lu, Valeria Arkhipova, Alexey Solodovnikov, Tsjerk A. Wassenaar, Siewert J. Marrink, Dmitry Korkin
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Cryo-EM structure of the Agrobacterium tumefaciens T4SS-associated T-pilus reveals stoichiometric protein-phospholipid assembly Structure (IF 5.871) Pub Date : 2023-03-03 Stefan Kreida, Akihiro Narita, Matthew D. Johnson, Elitza I. Tocheva, Anath Das, Debnath Ghosal, Grant J. Jensen
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Activation loop phosphorylation tunes conformational dynamics underlying Pyk2 tyrosine kinase activation Structure (IF 5.871) Pub Date : 2023-03-03 Tania M. Palhano Zanela, Alexzandrea Woudenberg, Karen G. Romero Bello, Eric S. Underbakke
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The C2 and PH domains of CAPS constitute an effective PI(4,5)P2-binding unit essential for Ca2+-regulated exocytosis Structure (IF 5.871) Pub Date : 2023-03-01 Li Zhang, Lei Li, Ziqing Wei, Hao Zhou, Haowen Liu, Shen Wang, Yijing Ren, Tiankai Dai, Jiafan Wang, Zhitao Hu, Cong Ma
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Structure and regulation of the myotonic dystrophy kinase-related Cdc42-binding kinase Structure (IF 5.871) Pub Date : 2023-02-27 Linda Truebestein, Sumire Antonioli, Elisabeth Waltenberger, Charlotte Gehin, Anne-Claude Gavin, Thomas A. Leonard
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Virus structures and molecular biology exchange glances Structure (IF 5.871) Pub Date : 2023-02-24 Polly Roy, David Veesler, Felix Rey
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TcpA from the Clostridium perfringens plasmid pCW3 is more closely related to the DNA translocase FtsK than to coupling proteins Structure (IF 5.871) Pub Date : 2023-02-24 Daouda A.K. Traore, Von Vergel L. Torres, Naureen Akhtar, Alexandra M. Gummer, Sarena F. Flanigan, Fasséli Coulibaly, Vicki Adams, James C. Whisstock, Julian I. Rood
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E6AP AZUL interaction with UBQLN1/2 in cells, condensates, and an AlphaFold-NMR integrated structure Structure (IF 5.871) Pub Date : 2023-02-23 Gwen R. Buel, Xiang Chen, Wazo Myint, Olumide Kayode, Varvara Folimonova, Anthony Cruz, Katarzyna A. Skorupka, Hiroshi Matsuo, Kylie J. Walters
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Structural and dynamic insights into α-synuclein dimer conformations Structure (IF 5.871) Pub Date : 2023-02-20 Joanna Zamel, Jiaxing Chen, Sofia Zaer, Paul David Harris, Paz Drori, Mario Lebendiker, Nir Kalisman, Nikolay V. Dokholyan, Eitan Lerner
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Structure and mechanism of sulfofructose transaldolase, a key enzyme in sulfoquinovose metabolism Structure (IF 5.871) Pub Date : 2023-02-17 Alexander J.D. Snow, Mahima Sharma, Palika Abayakoon, Spencer J. Williams, James N. Blaza, Gideon J. Davies
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2,5-Pyridinedicarboxylic acid is a bioactive and highly selective inhibitor of D-dopachrome tautomerase Structure (IF 5.871) Pub Date : 2023-02-17 Andrew Parkins, Pragnya Das, Varsha Prahaladan, Vanessa M. Rangel, Liang Xue, Banumathi Sankaran, Vineet Bhandari, Georgios Pantouris
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Computational pipeline provides mechanistic understanding of Omicron variant of concern neutralizing engineered ACE2 receptor traps Structure (IF 5.871) Pub Date : 2023-02-17 Soumya G. Remesh, Gregory E. Merz, Axel F. Brilot, Un Seng Chio, Alexandrea N. Rizo, Thomas H. Pospiech, Irene Lui, Mathew T. Laurie, Jeff Glasgow, Chau Q. Le, Yun Zhang, Devan Diwanji, Evelyn Hernandez, Jocelyne Lopez, Hevatib Mehmood, Komal Ishwar Pawar, Sergei Pourmal, Amber M. Smith, Fengbo Zhou, , Kliment A. Verba
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ATP-competitive and allosteric inhibitors induce differential conformational changes at the autoinhibitory interface of Akt1 Structure (IF 5.871) Pub Date : 2023-02-08 Alexandria L. Shaw, Matthew A.H. Parson, Linda Truebestein, Meredith L. Jenkins, Thomas A. Leonard, John E. Burke
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Solid-state NMR studies of amyloids Structure (IF 5.871) Pub Date : 2023-02-06 Jing Liu, Xia-lian Wu, Yu-teng Zeng, Zhi-heng Hu, Jun-xia Lu
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Structural insights into the evolutionary simplification of human ClpP activators Structure (IF 5.871) Pub Date : 2023-02-02
In this issue of Structure, Mabanglo et al. characterize five ClpP agonists termed TRs. The co-crystal structures reveal more robust shape and charge complementarities than the anti-cancer agent ONC201. These novel compounds are of potential therapeutic interest because they enhance ClpP proteolytic activity and have an inhibitory effect on tumor cell growth.
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Order and disorder bound together in SARS-CoV-2 Nsp1 suppress host translation Structure (IF 5.871) Pub Date : 2023-02-02
In this issue of Structure, Wang et al. investigate the interplay between folded and disordered regions of the SARS-CoV-2 non-structural protein 1 (Nsp1) that promotes the suppression of host protein translation. Their investigation will lead to novel avenues to therapeutically target critical viral functions necessary for host immune-response suppression.
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I shall be released: Assembly platform dynamics during type II secretion Structure (IF 5.871) Pub Date : 2023-02-02
In this issue of Structure, Dazzoni et al. solve the high-resolution homo- and hetero-dimeric structures of the Klebsiella oxytoca PulL and PulM C-terminal domains and unravel an uncharacterized dynamic interaction interface that is required for correct function of the type II secretion system.