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PRMT1 orchestrates with SAMTOR to govern mTORC1 methionine sensing via Arg-methylation of NPRL2 Cell Metab. (IF 29.0) Pub Date : 2023-11-24 Cong Jiang, Jing Liu, Shaohui He, Wei Xu, Runzhi Huang, Weijuan Pan, Xiaolong Li, Xiaoming Dai, Jianping Guo, Tao Zhang, Hiroyuki Inuzuka, Ping Wang, John M. Asara, Jianru Xiao, Wenyi Wei
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Adipo-glial signaling mediates metabolic adaptation in peripheral nerve regeneration Cell Metab. (IF 29.0) Pub Date : 2023-11-20 Venkat Krishnan Sundaram, Vlad Schütza, Nele H. Schröter, Aline Backhaus, Annika Bilsing, Lisa Joneck, Anna Seelbach, Clara Mutschler, Jose A. Gomez-Sanchez, Erik Schäffner, Eva Ernst Sánchez, Dagmar Akkermann, Christina Paul, Nancy Schwagarus, Silvana Müller, Angela Odle, Gwen Childs, David Ewers, Theresa Kungl, Maren Sitte, Robert Fledrich
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The tRNA-GCN2-FBXO22-axis-mediated mTOR ubiquitination senses amino acid insufficiency Cell Metab. (IF 29.0) Pub Date : 2023-11-17 Meng-Kai Ge, Cheng Zhang, Na Zhang, Ping He, Hai-Yan Cai, Song Li, Shuai Wu, Xi-Li Chu, Yu-Xue Zhang, Hong-Ming Ma, Li Xia, Shuo Yang, Jian-Xiu Yu, Shi-Ying Yao, Xiao-Long Zhou, Bing Su, Guo-Qiang Chen, Shao-Ming Shen
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The bidirectional immune crosstalk in metabolic dysfunction-associated steatotic liver disease Cell Metab. (IF 29.0) Pub Date : 2023-11-07 Keisuke Sawada, Hak Chung, Samir Softic, Maria E. Moreno-Fernandez, Senad Divanovic
Metabolic dysfunction-associated steatotic liver disease (MASLD) is an unabated risk factor for end-stage liver diseases with no available therapies. Dysregulated immune responses are critical culprits of MASLD pathogenesis. Independent contributions from either the innate or adaptive arms of the immune system or their unidirectional interplay are commonly studied in MASLD. However, the bidirectional
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Impact of biological sex and sex hormones on molecular signatures of skeletal muscle at rest and in response to distinct exercise training modes Cell Metab. (IF 29.0) Pub Date : 2023-11-07 Mark W. Pataky, Surendra Dasari, Kelly L. Michie, Kyle J. Sevits, A. Aneesh Kumar, Katherine A. Klaus, Carrie J. Heppelmann, Matthew M. Robinson, Rickey E. Carter, Ian R. Lanza, K. Sreekumaran Nair
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The circadian clock time tunes axonal regeneration Cell Metab. (IF 29.0) Pub Date : 2023-11-10 Francesco De Virgiliis, Franziska Mueller, Ilaria Palmisano, Jessica Sarah Chadwick, Lucia Luengo-Gutierrez, Angela Giarrizzo, Yuyang Yan, Matt Christopher Danzi, Carmen Picon-Muñoz, Luming Zhou, Guiping Kong, Elisabeth Serger, Thomas Haynes Hutson, Ines Maldonado-Lasuncion, Yayue Song, Christoph Scheiermann, Marco Brancaccio, Simone Di Giovanni
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Stress-induced β cell early senescence confers protection against type 1 diabetes Cell Metab. (IF 29.0) Pub Date : 2023-11-09 Hugo Lee, Gulcan Semra Sahin, Chien-Wen Chen, Shreyash Sonthalia, Sandra Marín Cañas, Hulya Zeynep Oktay, Alexander T. Duckworth, Gabriel Brawerman, Peter J. Thompson, Maria Hatzoglou, Decio L. Eizirik, Feyza Engin
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Bone marrow immune cells stop weight regain Cell Metab. (IF 29.0) Pub Date : 2023-11-07 Jing Yan, Cheng Hu
Weight regain is a major challenge in the long-term management of obesity; however, the underlying mechanisms remain unclear. Zhou et al. found that bone-marrow-derived CD7+ monocytes respond to fluctuating nutritional stress and suppress weight regain by promoting beige fat thermogenesis.
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Colonic macrophages eat and feed Cell Metab. (IF 29.0) Pub Date : 2023-11-07 Jan Van den Bossche
Macrophages not only secure host defense via phagocytosis but also play a key role in tissue homeostasis. A comprehensive study by Fritsch et al. reveals a novel mechanism by which macrophages in the colon deliver polyamines to epithelial cells to support self-renewal of the epithelium during periods of high proliferation.
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Regenerating the heart by metabolically reprogramming the cardiomyocyte epigenome Cell Metab. (IF 29.0) Pub Date : 2023-11-07 Xiaoqiang Tang
In mammal adolescence, cardiomyocytes rapidly exit the cell cycle, and heart regeneration in adults is limited after cardiac injury. Recent work by Li et al. in Nature revealed that inhibition of fatty acid oxidation can rewire cell metabolism and lead to epigenetic reprogramming of cardiomyocytes to an immature state that facilitates cardiomyocyte cell-cycle reentry and heart regeneration in adult
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Mitohormesis Cell Metab. (IF 29.0) Pub Date : 2023-11-07 Yu-Wei Cheng, Jie Liu, Toren Finkel
Perturbation of mitochondrial function can trigger a host of cellular responses that seek to restore cellular metabolism, cytosolic proteostasis, and redox homeostasis. In some cases, these responses persist even after the stress is relieved, leaving the cell or tissue in a less vulnerable state. This process—termed mitohormesis—is increasingly viewed as an important aspect of normal physiology and
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Dietary restriction of isoleucine increases healthspan and lifespan of genetically heterogeneous mice Cell Metab. (IF 29.0) Pub Date : 2023-11-07 Cara L. Green, Michaela E. Trautman, Krittisak Chaiyakul, Raghav Jain, Yasmine H. Alam, Reji Babygirija, Heidi H. Pak, Michelle M. Sonsalla, Mariah F. Calubag, Chung-Yang Yeh, Anneliese Bleicher, Grace Novak, Teresa T. Liu, Sarah Newman, Will A. Ricke, Kristina A. Matkowskyj, Irene M. Ong, Cholsoon Jang, Judith Simcox, Dudley W. Lamming
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Skeletal muscle-derived extracellular vesicles transport glycolytic enzymes to mediate muscle-to-bone crosstalk Cell Metab. (IF 29.0) Pub Date : 2023-11-07 Shixing Ma, Xiaotao Xing, Haisen Huang, Xin Gao, Xun Xu, Jian Yang, Chengcheng Liao, Xuanhao Zhang, Jinglun Liu, Weidong Tian, Li Liao
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Hyperinsulinemia acts via acinar insulin receptors to initiate pancreatic cancer by increasing digestive enzyme production and inflammation Cell Metab. (IF 29.0) Pub Date : 2023-10-31 Anni M.Y. Zhang, Yi Han Xia, Jeffrey S.H. Lin, Ken H. Chu, Wei Chuan K. Wang, Titine J.J. Ruiter, Jenny C.C. Yang, Nan Chen, Justin Chhuor, Shilpa Patil, Haoning Howard Cen, Elizabeth J. Rideout, Vincent R. Richard, David F. Schaeffer, Rene P. Zahedi, Christoph H. Borchers, James D. Johnson, Janel L. Kopp
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The PNPLA3 I148M variant increases ketogenesis and decreases hepatic de novo lipogenesis and mitochondrial function in humans Cell Metab. (IF 29.0) Pub Date : 2023-10-30 Panu K. Luukkonen, Kimmo Porthan, Noora Ahlholm, Fredrik Rosqvist, Sylvie Dufour, Xian-Man Zhang, Tiina E. Lehtimäki, Wenla Seppänen, Marju Orho-Melander, Leanne Hodson, Kitt Falk Petersen, Gerald I. Shulman, Hannele Yki-Järvinen
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Dynamic scRNA-seq of live human pancreatic slices reveals functional endocrine cell neogenesis through an intermediate ducto-acinar stage Cell Metab. (IF 29.0) Pub Date : 2023-10-27 Mayur Doke, Silvia Álvarez-Cubela, Dagmar Klein, Isabella Altilio, Joseph Schulz, Luciana Mateus Gonçalves, Joana Almaça, Christopher A. Fraker, Alberto Pugliese, Camillo Ricordi, Mirza M.F. Qadir, Ricardo L. Pastori, Juan Domínguez-Bendala
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Tyrosine catabolism enhances genotoxic chemotherapy by suppressing translesion DNA synthesis in epithelial ovarian cancer Cell Metab. (IF 29.0) Pub Date : 2023-10-26 Jie Li, Cuimiao Zheng, Qiuwen Mai, Xi Huang, Wenfeng Pan, Jingyi Lu, Zhengfan Chen, Suman Zhang, Chunyu Zhang, Hua Huang, Yangyang Chen, Hongbo Guo, Zhenyin Wu, Chunnuan Deng, Yiting Jiang, Bo Li, Junxiu Liu, Shuzhong Yao, Chaoyun Pan
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Dietary fructose-mediated adipocyte metabolism drives antitumor CD8+ T cell responses Cell Metab. (IF 29.0) Pub Date : 2023-10-19 Yuerong Zhang, Xiaoyan Yu, Rujuan Bao, Haiyan Huang, Chuanjia Gu, Qianming Lv, Qiaoqiao Han, Xian Du, Xu-Yun Zhao, Youqiong Ye, Ren Zhao, Jiayuan Sun, Qiang Zou
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Functional interrogation of twenty type 2 diabetes-associated genes using isogenic human embryonic stem cell-derived β-like cells Cell Metab. (IF 29.0) Pub Date : 2023-10-18 Dongxiang Xue, Narisu Narisu, D. Leland Taylor, Meili Zhang, Caleb Grenko, Henry J. Taylor, Tingfen Yan, Xuming Tang, Neelam Sinha, Jiajun Zhu, J. Jeya Vandana, Angie Chi Nok Chong, Angela Lee, Erin C. Mansell, Amy J. Swift, Michael R. Erdos, Aaron Zhong, Lori L. Bonnycastle, Ting Zhou, Shuibing Chen, Francis S. Collins
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CD36 maintains lipid homeostasis via selective uptake of monounsaturated fatty acids during matrix detachment and tumor progression Cell Metab. (IF 29.0) Pub Date : 2023-10-17 Alexander R. Terry, Veronique Nogueira, Hyunsoo Rho, Gopalakrishnan Ramakrishnan, Jing Li, Soeun Kang, Koralege C. Pathmasiri, Sameer Ahmed Bhat, Liping Jiang, Shafi Kuchay, Stephanie M. Cologna, Nissim Hay
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Metabolic support by macrophages sustains colonic epithelial homeostasis Cell Metab. (IF 29.0) Pub Date : 2023-10-06 Stephanie Deborah Fritsch, Nyamdelger Sukhbaatar, Karine Gonzales, Alishan Sahu, Loan Tran, Andrea Vogel, Mario Mazic, Jayne Louise Wilson, Stephan Forisch, Hannah Mayr, Raimund Oberle, Jakob Weiszmann, Martin Brenner, Roeland Vanhoutte, Melanie Hofmann, Sini Pirnes-Karhu, Christoph Magnes, Torben Kühnast, Wolfram Weckwerth, Christoph Bock, Thomas Weichhart
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Comprehensive quantification of metabolic flux during acute cold stress in mice Cell Metab. (IF 29.0) Pub Date : 2023-10-05 Marc R. Bornstein, Michael D. Neinast, Xianfeng Zeng, Qingwei Chu, Jessie Axsom, Chelsea Thorsheim, Kristina Li, Megan C. Blair, Joshua D. Rabinowitz, Zoltan Arany
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Restricting mealtime ameliorates neurodegeneration Cell Metab. (IF 29.0) Pub Date : 2023-10-03 Xiao Tian, David A. Sinclair
Alzheimer’s disease is often accompanied by disruptions in circadian rhythms, which may exacerbate the disease’s progression. In this issue, Whittaker and colleagues demonstrate that the modulation of circadian rhythms by time-restricted feeding can alter the disease trajectory in Alzheimer’s mouse models.
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Death-seq and ye shall find: A novel screening strategy for dying cells Cell Metab. (IF 29.0) Pub Date : 2023-10-03 Ryan Wallis, Cleo L. Bishop
Killing senescent cells to improve health-span holds great promise. However, screening for senescence-regulating genes and molecules is challenging because these cells do not proliferate. In this issue, Colville and Liu et al. develop Death-seq, a positive selection screening tool that overcomes this hurdle to offer broad genetic and pharmacological utility.
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Neutrophils resist ferroptosis and promote breast cancer metastasis through aconitate decarboxylase 1 Cell Metab. (IF 29.0) Pub Date : 2023-10-03 Yun Zhao, Zhongshun Liu, Guoqiang Liu, Yuting Zhang, Sheng Liu, Dailin Gan, Wennan Chang, Xiaoxia Peng, Eun Suh Sung, Keegan Gilbert, Yini Zhu, Xuechun Wang, Ziyu Zeng, Hope Baldwin, Guanzhu Ren, Jessica Weaver, Anna Huron, Toni Mayberry, Qingfei Wang, Yujue Wang, Xin Lu
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Ketogenesis promotes tolerance to Pseudomonas aeruginosa pulmonary infection Cell Metab. (IF 29.0) Pub Date : 2023-10-03 Kira L. Tomlinson, Ying-Tsun Chen, Alex Junker, AndreaCarola Urso, Tania Wong Fok Lung, Danielle Ahn, Casey E. Hofstaedter, Swikrity U. Baskota, Robert K. Ernst, Alice Prince, Sebastián A. Riquelme
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High dietary fructose promotes hepatocellular carcinoma progression by enhancing O-GlcNAcylation via microbiota-derived acetate Cell Metab. (IF 29.0) Pub Date : 2023-10-04 Peng Zhou, Wen-yi Chang, De-ao Gong, Jie Xia, Wei Chen, Lu-yi Huang, Rui Liu, Yi Liu, Chang Chen, Kai Wang, Ni Tang, Ai-long Huang
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Microbial-host isozyme: A novel target in “drug the bug” strategies for diabetes Cell Metab. (IF 29.0) Pub Date : 2023-10-03 Guojun Wu, Naisi Zhao, Liping Zhao
The role of the gut microbiome in metabolic diseases, such as diabetes, has emerged as a pivotal area of medical research. Wang et al.’s recent work reported that a gut bacteria-derived microbial-host isozyme, mimicking a human enzyme responsible for blood glucose regulation, can significantly impact the efficacy of diabetes medications.
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She didn’t start the fire: Mammary duct epithelial cells suppress adipocyte thermogenesis Cell Metab. (IF 29.0) Pub Date : 2023-10-03 David Merrick
Male and female mice display highly divergent responses to cold-induced thermogenic beiging of subcutaneous adipose tissues. Recently in Nature, Patel et al. showed that mammary duct epithelial cells respond to cold-induced sympathetic activity, triggering the secretion of lipocalin 2 (LCN2) to inhibit thermogenic differentiation of adjacent mammary adipocytes.
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Microbiota-gut-brain axis drives overeating disorders Cell Metab. (IF 29.0) Pub Date : 2023-10-03 Sijia Fan, Weiwei Guo, Dan Xiao, Mengyuan Guan, Tiepeng Liao, Sufang Peng, Airong Feng, Ziyi Wang, Hao Yin, Min Li, Jue Chen, Wei Xiong
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Regulatory T cells require IL6 receptor alpha signaling to control skeletal muscle function and regeneration Cell Metab. (IF 29.0) Pub Date : 2023-09-20 Maike Becker, Sini S. Joseph, Francisco Garcia-Carrizo, Robby Z. Tom, Daria Opaleva, Isabelle Serr, Matthias H. Tschöp, Tim J. Schulz, Susanna M. Hofmann, Carolin Daniel
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Bone marrow immune cells respond to fluctuating nutritional stress to constrain weight regain Cell Metab. (IF 29.0) Pub Date : 2023-09-12 Hai-Yan Zhou, Xu Feng, Li-Wen Wang, Rui Zhou, Heng Sun, Xin Chen, Ren-Bin Lu, Yan Huang, Qi Guo, Xiang-Hang Luo
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Death-seq identifies regulators of cell death and senolytic therapies Cell Metab. (IF 29.0) Pub Date : 2023-09-11 Alex Colville, Jie-Yu Liu, Cristina Rodriguez-Mateo, Samantha Thomas, Heather D. Ishak, Ronghao Zhou, Julian D.D. Klein, David W. Morgens, Armon Goshayeshi, Jayesh S. Salvi, David Yao, Kaitlyn Spees, Scott J. Dixon, Chun Liu, June-Wha Rhee, Celine Lai, Joseph C. Wu, Michael C. Bassik, Thomas A. Rando
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Fight, flight, and freeze! Cell Metab. (IF 29.0) Pub Date : 2023-09-05 Riya Keshri, Julie Mathieu, Hannele Ruohola-Baker
Just like time and tide, embryonic development waits for no man but progresses forcefully to its completion, with just one exception. Diapause is an enigmatic, reversible, dormant halt that protects the developing embryo. Cancer cells have evolved to hijack many useful stem cell capabilities, and diapause is no exception. Recent work has revealed a diapause-like cancer cell state, prompting the quest
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Seasonal light hours modulate peripheral clocks and energy metabolism in mice Cell Metab. (IF 29.0) Pub Date : 2023-09-08 Lewin Small, Leonidas S. Lundell, Jo Iversen, Amy M. Ehrlich, Morten Dall, Astrid L. Basse, Emilie Dalbram, Ann N. Hansen, Jonas T. Treebak, Romain Barrès, Juleen R. Zierath
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Vive la resistant starch: A potential treatment for metabolic dysfunction-associated steatohepatitis Cell Metab. (IF 29.0) Pub Date : 2023-09-05 Xiang Zhang, Jun Yu, Vincent Wai-Sun Wong
Metabolic dysfunction-associated steatotic liver disease is a prevalent chronic liver disease that affects nearly a third of the global adult population. Here, we preview a randomized controlled clinical trial on the potential benefits and underlying mechanisms of using resistant starch, a prebiotic, for treating this common liver condition.
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Metabolic elasticity: A new measure of age Cell Metab. (IF 29.0) Pub Date : 2023-09-05 Samuel Bennett, Shogo Sato
Promoting healthy aging is contingent on understanding the underlying mechanisms for the age-associated decline in metabolic physiology. Through developing a novel concept of “metabolic elasticity” to evaluate metabolic adaptability in response to cyclical changes in energy balance, Zhou et al. present an impactful gauge of metabolic health that is particularly relevant to aging.
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The neurocircuitry of fasting-induced glucocorticoid release Cell Metab. (IF 29.0) Pub Date : 2023-09-05 Nikolai P. Jaschke, Andrew Wang
Activation of the hypothalamus-pituitary-adrenal gland (HPA) axis confers adaptations to homeostatic perturbations including food scarcity. A comprehensive new study by Douglass et al. disentangled how agouti-related peptide (AgRP)-expressing neurons of the arcuate nucleus (ARC) trigger rapid HPA-axis activation in response to fasting, which is mediated by repression of a tonic, inhibitory neuro circuit
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Resistant starch decreases intrahepatic triglycerides in patients with NAFLD via gut microbiome alterations Cell Metab. (IF 29.0) Pub Date : 2023-09-05 Yueqiong Ni, Lingling Qian, Sara Leal Siliceo, Xiaoxue Long, Emmanouil Nychas, Yan Liu, Marsena Jasiel Ismaiah, Howell Leung, Lei Zhang, Qiongmei Gao, Qian Wu, Ying Zhang, Xi Jia, Shuangbo Liu, Rui Yuan, Lina Zhou, Xiaolin Wang, Qi Li, Yueliang Zhao, Hani El-Nezami, Weiping Jia
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A big STEP for treatment of heart failure with preserved ejection fraction Cell Metab. (IF 29.0) Pub Date : 2023-08-28 Subodh Verma, Barry A. Borlaug, Javed Butler, Melanie J. Davies, Dalane W. Kitzman, Mark C. Petrie, Sanjiv J. Shah, Nitish K. Dhingra, Mikhail N. Kosiborod
In the STEP-HFpEF trial, 2.4 mg semaglutide produced marked improvements in heart failure-related symptoms, physical limitations, and exercise function, and reduced inflammation and body weight in individuals with obesity HFpEF phenotype. These data usher in a new paradigm of targeting obesity as a therapeutic strategy in HFpEF.
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Preserved respiratory chain capacity and physiology in mice with profoundly reduced levels of mitochondrial respirasomes Cell Metab. (IF 29.0) Pub Date : 2023-08-25 Dusanka Milenkovic, Jelena Misic, Johannes F. Hevler, Thibaut Molinié, Injae Chung, Ilian Atanassov, Xinping Li, Roberta Filograna, Andrea Mesaros, Arnaud Mourier, Albert J.R. Heck, Judy Hirst, Nils-Göran Larsson
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Deciphering the decline of metabolic elasticity in aging and obesity Cell Metab. (IF 29.0) Pub Date : 2023-08-24 Qiuzhong Zhou, Lexiang Yu, Joshua R. Cook, Li Qiang, Lei Sun
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Comprehensive isotopomer analysis of glutamate and aspartate in small tissue samples Cell Metab. (IF 29.0) Pub Date : 2023-08-22 Feng Cai, Divya Bezwada, Ling Cai, Rohit Mahar, Zheng Wu, Mario C. Chang, Panayotis Pachnis, Chendong Yang, Sherwin Kelekar, Wen Gu, Bailey Brooks, Bookyung Ko, Hieu S. Vu, Thomas P. Mathews, Lauren G. Zacharias, Misty Martin-Sandoval, Duyen Do, K. Celeste Oaxaca, Eunsook S. Jin, Vitaly Margulis, Ralph J. DeBerardinis
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Circadian modulation by time-restricted feeding rescues brain pathology and improves memory in mouse models of Alzheimer’s disease Cell Metab. (IF 29.0) Pub Date : 2023-08-21 Daniel S. Whittaker, Laila Akhmetova, Daniel Carlin, Haylie Romero, David K. Welsh, Christopher S. Colwell, Paula Desplats
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GIPR/GLP-1R dual agonist therapies for diabetes and weight loss—chemistry, physiology, and clinical applications Cell Metab. (IF 29.0) Pub Date : 2023-08-16 Jonathan E. Campbell, Timo D. Müller, Brian Finan, Richard D. DiMarchi, Matthias H. Tschöp, David A. D’Alessio
The incretin system is an essential metabolic axis that regulates postprandial metabolism. The two incretin peptides that enable this effect are the glucose-dependent insulinotropic polypeptide (GIP) and the glucagon-like peptide 1 (GLP-1), which have cognate receptors (GIPR and GLP-1R) on islet β cells as well as in other tissues. Pharmacologic engagement of the GLP-1R is a proven strategy for treating
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Hyodeoxycholic acid alleviates non-alcoholic fatty liver disease through modulating the gut-liver axis Cell Metab. (IF 29.0) Pub Date : 2023-08-16 Junliang Kuang, Jieyi Wang, Yitao Li, Mengci Li, Mingliang Zhao, Kun Ge, Dan Zheng, Kenneth C.P. Cheung, Boya Liao, Shouli Wang, Tianlu Chen, Yinan Zhang, Congrong Wang, Guang Ji, Peng Chen, Hongwei Zhou, Cen Xie, Aihua Zhao, Weiping Jia, Xiaojiao Zheng, Wei Jia
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NSUN2 is a glucose sensor suppressing cGAS/STING to maintain tumorigenesis and immunotherapy resistance Cell Metab. (IF 29.0) Pub Date : 2023-08-15 Tingjin Chen, Zhi-Gang Xu, Jie Luo, Rajesh Kumar Manne, Zhengyu Wang, Che-Chia Hsu, Bo-Syong Pan, Zhen Cai, Pei-Jane Tsai, Yau-Sheng Tsai, Zhong-Zhu Chen, Hong-yu Li, Hui-Kuan Lin
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Protein-metabolite association studies identify novel proteomic determinants of metabolite levels in human plasma Cell Metab. (IF 29.0) Pub Date : 2023-08-14 Mark D. Benson, Aaron S. Eisman, Usman A. Tahir, Daniel H. Katz, Shuliang Deng, Debby Ngo, Jeremy M. Robbins, Alissa Hofmann, Xu Shi, Shuning Zheng, Michelle Keyes, Zhi Yu, Yan Gao, Laurie Farrell, Dongxiao Shen, Zsu-Zsu Chen, Daniel E. Cruz, Mario Sims, Adolfo Correa, Russell P. Tracy, Robert E. Gerszten
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Obesity-associated microglial inflammatory activation paradoxically improves glucose tolerance Cell Metab. (IF 29.0) Pub Date : 2023-08-11 John D. Douglass, Kelly M. Ness, Martin Valdearcos, Alice Wyse-Jackson, Mauricio D. Dorfman, Jeremy M. Frey, Rachael D. Fasnacht, Olivia D. Santiago, Anzela Niraula, Jineta Banerjee, Megan Robblee, Suneil K. Koliwad, Joshua P. Thaler
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Meet the author: Professor Zhijian Cai Cell Metab. (IF 29.0) Pub Date : 2023-08-08 Zhijian Cai
In this Q&A, Cell Metabolism’s Scientific Editor Rosalind Mott talks to Prof. Zhijian Cai about his paper “UBE2M-mediated neddylation of TRIM21 regulates obesity-induced inflammation and metabolic disorders” and his experience with publishing through Cell Press Community Review.
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Emerging therapies in cancer metabolism Cell Metab. (IF 29.0) Pub Date : 2023-08-08 Yi Xiao, Tian-Jian Yu, Ying Xu, Rui Ding, Yi-Ping Wang, Yi-Zhou Jiang, Zhi-Ming Shao
Metabolic reprogramming in cancer is not only a biological hallmark but also reveals treatment vulnerabilities. Numerous metabolic molecules have shown promise as treatment targets to impede tumor progression in preclinical studies, with some advancing to clinical trials. However, the intricacy and adaptability of metabolic networks hinder the effectiveness of metabolic therapies. This review summarizes
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The diapause-like colorectal cancer cells induced by SMC4 attenuation are characterized by low proliferation and chemotherapy insensitivity Cell Metab. (IF 29.0) Pub Date : 2023-08-04 Xuedan Sun, Lifang He, Hong Liu, Rick Francis Thorne, Taofei Zeng, Liu Liu, Bo Zhang, Miao He, Yabin Huang, Mingyue Li, Enyi Gao, Mengyao Ma, Cheng Cheng, Fanzheng Meng, Chuandong Lang, Hairui Li, Wanxiang Xiong, Shixiang Pan, Delong Ren, Bingyi Dang, Lianxin Liu
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Neddylation of phosphoenolpyruvate carboxykinase 1 controls glucose metabolism Cell Metab. (IF 29.0) Pub Date : 2023-08-03 María J. Gonzalez-Rellan, Uxía Fernández, Tamara Parracho, Eva Novoa, Marcos F. Fondevila, Natalia da Silva Lima, Lucía Ramos, Amaia Rodríguez, Marina Serrano-Maciá, Gonzalo Perez-Mejias, Pilar Chantada-Vazquez, Cristina Riobello, Christelle Veyrat-Durebex, Sulay Tovar, Roberto Coppari, Ashwin Woodhoo, Markus Schwaninger, Vincent Prevot, Teresa C. Delgado, Miguel Lopez, Ruben Nogueiras
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Hepatic levels of S-adenosylmethionine regulate the adaptive response to fasting Cell Metab. (IF 29.0) Pub Date : 2023-07-31 Alba Capelo-Diz, Sofía Lachiondo-Ortega, David Fernández-Ramos, Jorge Cañas-Martín, Naroa Goikoetxea-Usandizaga, Marina Serrano-Maciá, Maria J. González-Rellan, Laura Mosca, Joan Blazquez-Vicens, Alberto Tinahones-Ruano, Marcos F. Fondevila, Mason Buyan, Teresa C. Delgado, Virginia Gutierrez de Juan, Paula Ayuso-García, Alejandro Sánchez-Rueda, Sergio Velasco-Avilés, Héctor Fernández-Susavila, Cristina
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Tumor aerobic glycolysis confers immune evasion through modulating sensitivity to T cell-mediated bystander killing via TNF-α Cell Metab. (IF 29.0) Pub Date : 2023-07-27 Lijian Wu, Yiteng Jin, Xi Zhao, Kaiyang Tang, Yaoning Zhao, Linjie Tong, Xuerong Yu, Ke Xiong, Ce Luo, Jiajun Zhu, Fubing Wang, Zexian Zeng, Deng Pan
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The lncRNA HOXA11os regulates mitochondrial function in myeloid cells to maintain intestinal homeostasis Cell Metab. (IF 29.0) Pub Date : 2023-07-25 Liraz Shmuel-Galia, Fiachra Humphries, Tim Vierbuchen, Zhaozhao Jiang, Nolan Santos, John Johnson, Boris Shklyar, Leonel Joannas, Nicholas Mustone, Shany Sherman, Doyle Ward, JeanMarie Houghton, Christina E. Baer, Aisling O’Hara, Jorge Henao-Mejia, Kasper Hoebe, Katherine A. Fitzgerald
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Lactate modulates iron metabolism by binding soluble adenylyl cyclase Cell Metab. (IF 29.0) Pub Date : 2023-07-21 Wei Liu, Shuping Zhang, Quanjin Li, Yue Wu, Xuan Jia, Wenya Feng, Zhaolong Li, Yali Shi, Qingzhi Hou, Juan Ma, Yajun Liu, Pu Gao, Tomas Ganz, Sijin Liu
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The pathogenic “symphony” in type 1 diabetes: A disorder of the immune system, β cells, and exocrine pancreas Cell Metab. (IF 29.0) Pub Date : 2023-07-20 Mark A. Atkinson, Raghavendra G. Mirmira
Type 1 diabetes (T1D) is widely considered to result from the autoimmune destruction of insulin-producing β cells. This concept has been a central tenet for decades of attempts seeking to decipher the disorder’s pathogenesis and prevent/reverse the disease. Recently, this and many other disease-related notions have come under increasing question, particularly given knowledge gained from analyses of
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GDF15 increases insulin action in the liver and adipose tissue via a β-adrenergic receptor-mediated mechanism Cell Metab. (IF 29.0) Pub Date : 2023-07-19 Kim A. Sjøberg, Casper M. Sigvardsen, Abdiel Alvarado-Diaz, Nicoline Resen Andersen, Mark Larance, Randy J. Seeley, Peter Schjerling, Jakob G. Knudsen, Georgios Katzilieris-Petras, Christoffer Clemmensen, Sebastian Beck Jørgensen, Katrien De Bock, Erik A. Richter
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Liver mitochondrial cristae organizing protein MIC19 promotes energy expenditure and pedestrian locomotion by altering nucleotide metabolism Cell Metab. (IF 29.0) Pub Date : 2023-07-19 Jee Hyung Sohn, Beste Mutlu, Pedro Latorre-Muro, Jiaxin Liang, Christopher F. Bennett, Kfir Sharabi, Noa Kantorovich, Mark Jedrychowski, Steven P. Gygi, Alexander S. Banks, Pere Puigserver