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Unique structural features define the decarboxylation activity of a CYP152 fatty acid decarboxylase from Lacicoccus alkaliphilus. J. Biol. Chem. (IF 4.0) Pub Date : 2025-06-19 Suppalak Phaisan,Aisaraphon Phintha,Duangthip Trisrivirat,Narin Lawan,Jeerus Sucharitakul,Ailada Charoenpol,Pratchaya Watthaisong,Hideaki Tanaka,Genji Kurisu,Pimchai Chaiyen
Cytochrome P450 CYP152s catalyze decarboxylation of fatty acids to generate terminal alkenes, valuable compounds for various industries. Here, we identified, overexpressed, and characterized a new CYP152 enzyme from Lacicoccus alkaliphilus (OleTLA), and compared its biophysical and biochemical properties with the well-studied OleTJE from Jeotgalicoccus sp. 8456. Improved expression protocols gave the
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Silencing PIM1 inhibits ENO1-induced AKT activation and attenuates fibrillogenesis during spinal cord injury-induced skeletal muscle atrophy. J. Biol. Chem. (IF 4.0) Pub Date : 2025-06-19 Xiao Yu,Jiang Cao,Binyu Wang,Jiaju Fu,Jingcheng Liu,Tao Sui,Zi Wang,Chaoqin Wu,Jie Chang,Xiaojian Cao,Shaohua Zhang
Spinal cord injury (SCI) induces rapid and extensive skeletal muscle atrophy. During skeletal muscle atrophy, numerous extracellular matrix (ECM) and fibroblasts accumulate, impairing muscle function. The pro-viral Integration site for moloney murine leukaemia virus kinases-1(PIM1) is considered a positive regulator of inflammation. In our study, we found that PIM1 was overexpressed in the fibrotic
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Crosstalk between iron and flavins in the opportunistic fungal pathogen Candida albicans. J. Biol. Chem. (IF 4.0) Pub Date : 2025-06-19 Marika S David,Zhengkai Zhu,Maranda R McDonald,Mohsen Badiee,I Phillip Mortimer,Anthony K L Leung,Valeria C Culotta
As part of the innate immune response, the host withholds metal micronutrients such as iron (Fe) from invading pathogens. To survive such Fe-limitation, the opportunistic fungal pathogen Candida albicans has evolved elaborate responses to Fe-starvation stress. One such adaptation involves secretion of flavins, yellow isoalloxazine compounds that serve important redox roles in biology. Why the organism
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The binding sites of carbon dioxide, nitrous oxide, and xenon reveal a putative exhaust channel for bovine cytochrome c oxidase. J. Biol. Chem. (IF 4.0) Pub Date : 2025-06-19 Kazumasa Muramoto,Tomohiro Ide,Kyoko Shinzawa-Itoh
Cytochrome c oxidase (CcO) catalyzes oxygen (O2) reduction at the heme a3-CuB site in the transmembrane region of the enzyme. It has been proposed that the hydrophobic channel that connects the transmembrane surface of subunit III through subunit I to the heme a3-CuB site is the O2 transfer pathway. Gas molecules other than O2, including carbon dioxide (CO2) generated in the TCA cycle, should also
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CryoEM Structure of Rv2531c Reveals Cofactor-Induced Tetramer-Dimer Transition in a Tuberculin Amino Acid Decarboxylase. J. Biol. Chem. (IF 4.0) Pub Date : 2025-06-19 Jyoti Gupta,Tina Izard
The survival of Mycobacterium tuberculosis relies on its ability to adapt to dynamic and hostile host environments. Amino acid decarboxylases play a crucial role in these adaptations, but their structural and mechanistic properties are not fully understood. Bioinformatic analyses revealed that these enzymes exist in three distinct forms based on their domain organization. We used cryogenic electron
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Rag GTPases control lysosomal acidification by regulating v-ATPase assembly in Drosophila. J. Biol. Chem. (IF 4.0) Pub Date : 2025-06-19 Ying Zhou,Xiaodie Yang,Wenyu Xu,Sulin Shen,Weikang Fan,Guoqiang Meng,Yang Cheng,Yingying Lu,Youheng Wei
The Rag GTPases play an important role in sensing amino acids and activating the target of rapamycin complex 1 (TORC1), a master regulator of cell metabolism. Previously, we have shown that GDP-bound RagA stimulates lysosome acidification and autophagic degradation, which are essential for young egg chamber survival under starvation in Drosophila. However, the underlying mechanism is unclear. Here
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How short is too short for amyloid fibrils?: molecular dynamics of oligomers of infectious prion core structures. J. Biol. Chem. (IF 4.0) Pub Date : 2025-06-19 Efrosini Artikis,Amitava Roy,Byron Caughey
In many proteinopathies, the relative conformations of amyloid fibrils versus smaller oligomers remain unclear. Most tissue-derived isolates of infectious prion protein (PrP) prions are predominantly fibrillar. A few studies have asserted that prion amyloid fibrils efficiently disassemble into dimeric to tetrameric "elemental bricks" under certain detergent or chaotropic conditions, but our companion
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Humanin variants aggregate to produce different fibril morphologies. J. Biol. Chem. (IF 4.0) Pub Date : 2025-06-19 Daniel L Morris,Sarah B Nyenhuis,James M Gruschus,David A Nyenhuis,Rashmi Puja,Jenny E Hinshaw,Nico Tjandra
Humanin is an endogenous human peptide with cytoprotective effects including inhibition of apoptosis via interaction with BCL-2 proteins such as BAX. The therapeutic benefits of HN have been well-documented, and administering humanin and related endogenous human peptides for treatment of disease, aging, and enhancement of athletic performance is becoming more widespread. However, very little is known
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Acyl chains stabilize the acylated domain and determine the receptor-mediated interaction of the Bordetella adenylate cyclase toxin with cell membrane. J. Biol. Chem. (IF 4.0) Pub Date : 2025-06-19 Carlos Espinosa-Vinals,Jan Stransky,Radim Osicka,Adriana Osickova,David Jurnecka,Peter Sebo,Ladislav Bumba
Acylated domains (AD), like that of the Bordetella pertussis adenylate cyclase toxin (CyaA), are structures found in all pore-forming toxins from the family of Repeat-in-ToXin (RTX) proteins. These AD segments are fatty-acylated on ε-amino groups of conserved lysine residues, such as the K860 and K983 residues of CyaA. The ε-amide linked acyl chains are essential for toxin activity and promote irreversible
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The human autophagy-initiating complexes ULK1C and PI3KC3-C1. J. Biol. Chem. (IF 4.0) Pub Date : 2025-06-19 Minghao Chen,James Hurley
The unc-51-like kinase complex (ULK1C) and the class III phosphatidylinositol 3-kinase complex I (PI3KC3-C1) are the key regulators of macroautophagy initiation. Understanding the assembly and coordination of these two complexes is essential for deciphering their cellular regulation and targeting them for therapeutic enhancement. This review highlights recent advances in our understanding of the structural
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The Escherichia coli RelB antitoxin C-terminus is essential for RelE toxin suppression and transcriptional repression. J. Biol. Chem. (IF 4.0) Pub Date : 2025-06-18 Julia Tanquary,Ian J Pavelich,Marcin Grabowicz,Christine M Dunham
Bacterial type II toxin-antitoxin (TA) systems exhibit high specificity within each pair to ensure precise recognition of the toxin by its cognate antitoxin to inhibit toxicity of the free toxin. Despite high structural similarity among some TAs, crosstalk between non-cognate TA pairs is rare. To determine how the E. coli RelB antitoxin suppresses its cognate RelE toxin, we engineered C-terminal truncations
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YEATS2 O-GlcNAcylation Promotes Chromatin Association of the ATAC Complex and Lung Cancer Tumorigenesis. J. Biol. Chem. (IF 4.0) Pub Date : 2025-06-18 Jianxin Zhao,Zheng Zhao,Wen Zhou,Jianzhi Zhang,Jinfeng Chen,Jianwei Sun,Jing Li
The intracellular O-linked N-acetylglucosamine (O-GlcNAc) modification is known to be enriched in the nucleus and on chromatin, but many of its chromatin targets remain to be identified. Herein we demonstrate the O-GlcNAcylation of YEATS Domain Containing 2 (YEATS2), a subunit of the chromatin Ada-two-A-containing (ATAC) complex and a reader of histone H3K27ac. We show that YEATS2 interacts with the
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TFAP2C Drives Cisplatin Resistance in Bladder Cancer by Upregulating YAP and Activating β-Catenin Signaling. J. Biol. Chem. (IF 4.0) Pub Date : 2025-06-18 Qiufeng Pan,Changmin Zou,Zhigen Lin,Hao Tang,Zepu Long,Longwang Wang
Cisplatin-based chemotherapy is a conventional therapy for muscle-invasive bladder cancer (BC); However, its efficacy is often limited by the emergence of resistance to cisplatin. Yes-associated protein (YAP) and β-catenin are involved in this resistance, yet their upstream regulators are not well defined. This study investigates the role of TFAP2C in regulating YAP expression and its impact on cisplatin
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A kinetic model of copper homeostasis in Saccharomyces cerevisiae. J. Biol. Chem. (IF 4.0) Pub Date : 2025-06-16 Cade Dulaney,Jay R Walton,Paul A Lindahl
Rather than inhibiting copper entry when grown on high Cu, yeast cells import excessive Cu while simultaneously increasing expression of metallothionein CUP1 which then sequesters the excess Cu. An ordinary-differential-equations-based kinetic model was developed to investigate this unusual behavior. The assumed reaction network included 25 reactions and 10 components in the cytosol of yeast cells
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Molecular arrangements that accompany binding of rice xylanase inhibitor protein OsXIP and the Rhizopus oryzae GH11 xylanase RXyn2. J. Biol. Chem. (IF 4.0) Pub Date : 2025-06-16 Takayuki Ohnuma,Jun Tanaka,Harutada Ozaki,Keigo Mitsui,Daichi Tsujitsugu,Miki Okugawa,Toru Takeda,Makoto Ihara,Tamo Fukamizo,Daijiro Takeshita
Plants have evolved xylanase inhibitor proteins as part of their defense mechanisms against phytopathogens. The rice xylanase inhibitor protein (OsXIP) is structurally similar to GH18 chitinase and homologous to wheat XIP-type inhibitor (XIP-I), which inhibits both GH10 and GH11 xylanases. Various inhibition and interaction analyses showed that OsXIP competitively inhibits the hydrolytic activity of
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The redox landscape of pyruvate:ferredoxin oxidoreductases reveals often conserved Fe-S cluster potentials. J. Biol. Chem. (IF 4.0) Pub Date : 2025-06-16 Sheila C Bonitatibus,Ryan V Pham,Andrew C Weitz,Madeline M Lopéz-Muñoz,Bin Li,William W Metcalf,Satish K Nair,Sean J Elliott
Here we investigate the thermodynamic driving force of internal electron transfer (ET) of pyruvate:ferredoxin oxidoreductases (PFORs), by comparing the redox properties of a series of PFORs from Chlorobaculum tepidum (Ct), Magnetococcus marinus (Mm), Methanosarccina acetivorans (Ma), as well as revisiting the single historical precedent, the enzyme from Desulfovibrio africanus. These enzymes require
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CpgD is a phosphoglycerate cytidylyltransferase required for ceramide diphosphoglycerate synthesis J. Biol. Chem. (IF 4.0) Pub Date : 2025-06-16 Tanisha Dhakephalkar, Ziqiang Guan, Eric A. Klein
LPS is essential in most Gram-negative bacteria, but mutants of several species have been isolated that can survive in its absence. Caulobacter crescentus viability in the absence of LPS is partially dependent on the anionic sphingolipid ceramide diphosphoglycerate (CPG2). Genetic analyses showed that ccna_01210, which encodes a nucleotidyltransferase, is required for CPG2 production. Using purified
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Targeted incorporation of collagen IV to the basement membrane: a step forward for developing extracellular protein therapies J. Biol. Chem. (IF 4.0) Pub Date : 2025-06-14 Elena N. Pokidysheva, Sara F. Tufa, Douglas R. Keene, Billy G. Hudson, Sergei P. Boudko
The collagen IV scaffold serves as a fundamental structural unit of the basement membrane (BM). Understanding its structure, assembly, and function is essential for tissue engineering, design of organoid models, and developing therapies for diseases such as Alport syndrome, Gould syndrome, psoriasis, eye abnormalities, hearing loss, and others where collagen IV is required for structural integrity
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FAK activity exacerbates disturbed flow-mediated atherosclerosis via VEGFR2-CBL-NF-κB signaling J. Biol. Chem. (IF 4.0) Pub Date : 2025-06-14 James M. Murphy, Duyen Thi Kieu Tran, Kyuho Jeong, Ly Nguyen, Mai Thi Nguyen, Dhananjay Tambe, Hanjoong Jo, Eun-Young Erin Ahn, Ssang-Taek Steve Lim
Atherosclerosis develops at predictable sites in the vasculature where branch points and curvatures create non-laminar disturbed flow. This disturbed flow causes vascular inflammation by increased endothelial cell (EC) barrier permeability and the expression of inflammatory genes such as vascular cell adhesion molecule-1 (VCAM-1). Vascular endothelial growth factor receptor 2 (VEGFR2) regulates flow-induced
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Characterization of the activity of KTX-1001, a small molecule inhibitor of multiple myeloma SET domain (MMSET) using surface plasmon resonance (SPR) J. Biol. Chem. (IF 4.0) Pub Date : 2025-06-14 Chad A. Lewis, Charles Schmidt, Lisa Beebe, Terrence J. Connolly
KTX-1001 is a small molecule inhibitor of MMSET in early clinical development for multiple myeloma. It was identified as a potent and selective inhibitor of MMSET (also known as NSD2) using a high throughput biochemical assay with LC/MS-MS detection of SAH production as the endpoint. Subsequent evaluation of the binding of KTX-1001 to its target was conducted using surface plasmon resonance (SPR) to
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Colchicine inhibits vascular calcification by suppression inflammasome activation through the enhancement of the Sirt2-PP2Ac signaling pathway J. Biol. Chem. (IF 4.0) Pub Date : 2025-06-14 Shu Yang, Heming Huang, Kewei Jiang, Ying Peng, Zhen Liang, Xinyu Gong, Lixing Li, Yanchun Li, Buchun Zhang, Yuanli Chen, Xiaoxiao Yang
Colchicine (Col) is a traditional herbal medicine derived from the plant Colchicum autumnale. With the property of anti-inflammation, Col has been demonstrated certain therapeutic effects in cardiovascular diseases (CVDs). Vascular calcification is positively related to the morbidity and mortality of CVDs. However, the specific cardiovascular conditions for which Col is effective remain unclear, particularly
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CH−π Interactions Confer Orientational Flexibility in Protein–Carbohydrate Binding Sites J. Biol. Chem. (IF 4.0) Pub Date : 2025-06-14 Allison M. Keys, David W. Kastner, Laura L. Kiessling, Heather J. Kulik
Protein−carbohydrate binding plays an essential role in biological processes including cellular recognition and immune signaling. However, glycans are hydrophilic with limited hydrophobic surfaces, a challenge for selective recognition by proteins. CH–π stacking interactions are pervasive in protein-carbohydrate binding sites and have emerged as critical drivers of protein–carbohydrate recognition
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Cytochrome P450BM-3 and P450 11A1 retain Compound I (FeO3+) chemistry with electrophilic substrates poised for Compound 0 (Fe3+O2¯) reactions J. Biol. Chem. (IF 4.0) Pub Date : 2025-06-14 Kevin D. McCarty, Yasuhiro Tateishi, F. Peter Guengerich
The catalytic cycle of cytochrome P450 (P450) enzymes involves ferric peroxide anion (Fe3+O2¯, Compound 0) and perferryl oxygen (FeO3+, Compound I) intermediates. Compound I is generally viewed as responsible for most P450-catalyzed oxidations, but Compound 0 has been implicated in the oxidation of some carbonyl compounds, particularly deformylation reactions. We considered the hypothesis that Compound
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Molecular basis for Gβγ-SNARE mediated inhibition of synaptic vesicle fusion. J. Biol. Chem. (IF 4.0) Pub Date : 2025-06-14 Anna R. Eitel, Benjamin K. Mueller, Ali I. Kaya, Montana Young, Jackson B. Cassada, Eric W. Bell, Lauren Schnitkey, Zack Zurawski, Yun Y. Yim, Qiangjun Zhou, Jens Meiler, Heidi E. Hamm
Neurotransmitter release is a complex process involving tightly controlled co-factors and protein-protein interactions. G protein coupled receptors negatively regulate exocytosis via the interaction of G-protein βγ (Gβγ) heterodimers with soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex. The neuronal ternary SNARE complex comprises synaptosomal-associated protein-25
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Structural biology of Parkinson’s Disease-associated Leucine-Rich Repeat Kinase 2 (LRRK2) J. Biol. Chem. (IF 4.0) Pub Date : 2025-06-14 Andres E. Leschziner
Leucine Rich Repeat Kinase 2 (LRRK2) has gone, in a little over two decades, from a novel gene linked to cases of Parkinson’s Disease (PD) in one family to being the main actionable target for PD therapeutics, with several clinical trials targeting it currently underway. While much remains to be understood about LRRK2—including, chiefly, why its increased activity is linked to PD—much has also been
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Abstract 3064 Bioengineering with synthetic cells J. Biol. Chem. (IF 4.0) Pub Date : 2025-06-13 Kate Adamala
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Abstract 3059 Engineering Bacteria to Grow into Macroscopic Living Materials with Tailored Properties J. Biol. Chem. (IF 4.0) Pub Date : 2025-06-13 Caroline Ajo-Franklin
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Abstract 3047 Advancing the frontiers of design-driven medicine with synthetic biology J. Biol. Chem. (IF 4.0) Pub Date : 2025-06-13 Joshua Leonard
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Abstract 3030 Phage-Based Approaches to Eliminate or Alter Bacteria within Complex Microbial Communities J. Biol. Chem. (IF 4.0) Pub Date : 2025-06-13 Mark Mimee
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Abstract 2951 Engineering high-precision, dynamic genetic control systems for cell fate programming J. Biol. Chem. (IF 4.0) Pub Date : 2025-06-13 Kate Galloway
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Abstract 2939 Developing RetroDecoys for Transcriptional Regulation J. Biol. Chem. (IF 4.0) Pub Date : 2025-06-13 Linhan Wang, Adriann Brodeth, Seth Shipman
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Abstract 2841 Development of an engineered light-regulated biotin ligase for interrogation of protein interactions with high temporal resolution J. Biol. Chem. (IF 4.0) Pub Date : 2025-06-13 Hanna Bradford-Olson, Nic Leschinsky, Jacob Matsche, Ryuhjin Ahn, Forest White, Andrei Karginov
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Abstract 2661 From Olive Oil to Nanodots: A Green Chemistry Approach J. Biol. Chem. (IF 4.0) Pub Date : 2025-06-13 Maria Guillen-Mendez, Tasfia Howlader, Srika Talanki
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Abstract 2612 Uncovering the Coloration Mechanism of Mercenaria mercenaria J. Biol. Chem. (IF 4.0) Pub Date : 2025-06-13 Jillian Zerkowski, Dan Wilson
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Abstract 2425 Large serine integrases: how do they know which way to go? J. Biol. Chem. (IF 4.0) Pub Date : 2025-06-13 Phoebe Rice, Heewhan Shin, Femi Olorunniji, Phoebe Rice
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Abstract 2405 Building functional chimeras for biosensing and synthetic biology using CRISPR J. Biol. Chem. (IF 4.0) Pub Date : 2025-06-13 Jacinda Pujols, Kyutae Lee, Nick Kapolka, Alexander Weber, Daniel Isom
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Abstract 2355 Production of Preassembled Protein Nanopores and Their Characterization in Unsupported Lipid Bilayers J. Biol. Chem. (IF 4.0) Pub Date : 2025-06-13 Lisa Keranen Burden, Annika Evenson, Sarah Koeneman, Rich Michael, Daniel Burden
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Abstract 2211 A phage display approach for optimizing RNA modification-binding antibodies to advance epitranscriptomics research J. Biol. Chem. (IF 4.0) Pub Date : 2025-06-13 Cody White, Scott Aoki, Jeffery Tharp
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Abstract 2195 Adapting deGradFP to yeast to study protein degradation J. Biol. Chem. (IF 4.0) Pub Date : 2025-06-13 Chelsea Kotey, Eric Cooper
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Abstract 2057 Development of a Quantum Dot-Based Cell-Free Cadmium Biosensor Component with Multiplexing Potential for the Detection of Heavy Metals in Fluids J. Biol. Chem. (IF 4.0) Pub Date : 2025-06-13 Sara Desai, Era Srivastava, Kevin Liu, Meghna Thakur, Gregory Ellis, Igor Medintz, Divita Mathur
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Abstract 2017 Engineering a Minimal Synthetic Cell Cycle in a PURE Cell-Free Protein Synthesis System J. Biol. Chem. (IF 4.0) Pub Date : 2025-06-13 Viktoriia Belousova, Petra Schwille
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Abstract 2008 Expanding LOCKR Applications: Building a Protein Control System for Bacteria J. Biol. Chem. (IF 4.0) Pub Date : 2025-06-13 William Boswell, Precious Ainabor, Augustus Isaac, Walter Novak, Erika Sorensen
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Abstract 1958 Construction of a synthetic probiotic bacteria to in-situ delivery of anti-SARS-CoV2-nanobodies J. Biol. Chem. (IF 4.0) Pub Date : 2025-06-13 Carolina Portero, Claire Smith, Shiyong Wu, Yuxi Zhou, M. Raquel Marchán-Rivadeneira, Yong Han
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Abstract 1941 Enhanced cellular and transdermal delivery of the modified chromatin using cell-penetrating peptide display J. Biol. Chem. (IF 4.0) Pub Date : 2025-06-13 Jeong Park, Xinghan Zhang, Yuxin Liang
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Abstract 1847 Advancing Carbon-Negative Energy Through Cyanobacteria Based Biophotovoltaics J. Biol. Chem. (IF 4.0) Pub Date : 2025-06-13 Grace Widjaja, Elina Roshchupkina, Weronika Kierzenka, Claire English, Shuhan Zhang, Caleb Lee, Jack Reinstein, Seeya Khattar, Anne Meyer
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Abstract 1528 A mutation to the exit tunnel of the E. coli ribosome improves translation of polyproline sequences with implications for incorporation of cyclic β-amino acids J. Biol. Chem. (IF 4.0) Pub Date : 2025-06-13 Alexandra Kent, Katelyn Fitzgerald, Jessica Vance, Martina de Teresa, Carly Schissel, Alanna Schepartz, Jamie Cate
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Abstract 1377 Using cryo-EM structures of Escherchia coli ribosomes to expand the substrate scope of translation J. Biol. Chem. (IF 4.0) Pub Date : 2025-06-13 Chandrima Majumdar, Isaac Knudson, Amos Nissley, Annika Velez, Carson Gido, Alanna Schepartz, Jamie Cate
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Abstract 1302 Phylogenetic and structure guided design of metal sensitive transcription factors J. Biol. Chem. (IF 4.0) Pub Date : 2025-06-13 Claire Schleicher, Nathan Novy, Srivatsan Raman
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Abstract 1141 A blueprint for biomolecular condensation driven by bacterial microcompartment encapsulation peptides J. Biol. Chem. (IF 4.0) Pub Date : 2025-06-13 Daniel Trettel, Cesar López, Eliana Rodrigquez, Babetta Marrone, Raul Gonzalez-Esquer
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Abstract 1118 A logistic regression model predicts oscillation regimes in the MinDE reaction diffusion system J. Biol. Chem. (IF 4.0) Pub Date : 2025-06-13 Elliott Weix, Dennis Bolshakov, Thomas Galateo, Rohith Rajasekaran, Scott Coyle
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Abstract 1076 Creation of a new genomically recoded organism with a single non-degenerate stop codon J. Biol. Chem. (IF 4.0) Pub Date : 2025-06-13 Jesse Rinehart, Farren Isaacs, Michael Grome
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Abstract 1025 The devil is in the (molecular) details: Engineering bacterial microcompartments for sustainable chemical production J. Biol. Chem. (IF 4.0) Pub Date : 2025-06-13 Danielle Tullman-Ercek
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Abstract 2902 The Role of Klotho-alpha in the Stabilization of FGFR and Its Effects on Longevity through FGF23 Pathways J. Biol. Chem. (IF 4.0) Pub Date : 2025-06-13 Daniel Shannon, Ben Gill, Emmet Pease, Luis Marshall, Connor Connolly, Liam Knight, Jake Allen, Hudson Arnberg, Kyle Borgemenke, Adam Falci
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Abstract 3061 Control of IP3 receptor trafficking at the ER-mitochondrial contact sites J. Biol. Chem. (IF 4.0) Pub Date : 2025-06-13 Gyorgy Hajnoczky, Mate Katona, David Weaver, Arijita Ghosh, Yubin Zhou, Lian He
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Abstract 3060 Structures of the PI3Ka/KRas complex on lipid bilayers reveal the molecular mechanism of PI3Ka activation J. Biol. Chem. (IF 4.0) Pub Date : 2025-06-13 Kliment Verba, Hayarpi Torosyan, Michael Paul, Brigitte Meyer, Allison Maker, Natalia Jura
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Abstract 3058 Protein Tyrosine Phosphatases and the regulation of cell signaling: from basic research to new therapeutics J. Biol. Chem. (IF 4.0) Pub Date : 2025-06-13 Nicholas Tonks
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Abstract 3051 The C2 domain augments Ras GTPase Activating Protein catalytic activity J. Biol. Chem. (IF 4.0) Pub Date : 2025-06-13 Titus Boggon, Max Paul, Di Chen, Kimberly Vish, Nathaniel Lartey, Zachary Freeman, Thomas Saunders, Amy Stiegler, Philip King
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Abstract 3037 Discovering how receptor tyrosine kinases are activated and Signals By: Joseph Schlessinger Yale University, New Haven CT, USA J. Biol. Chem. (IF 4.0) Pub Date : 2025-06-13 Joseph Schlessinger
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Abstract 2906 Evaluation of Osteogenic Molecules in Mesenchymal Stem Cells Differentiated into Osteoblasts Cultured on Silica and 3D Printed PLA Scaffolds for Bone Graft Formation J. Biol. Chem. (IF 4.0) Pub Date : 2025-06-13 Juan Luis Amaya Espinoza, Maria Antonieta Suarez Souto, José Jesús Pérez Correa, Alexia Ishel Osnaya Moctezuma, Gisela Gutiérrez Iglesias