-
Transplanted human organoids for preclinical drug testing. Lab Anim. (IF 9.667) Pub Date : 2022-08-15 Alexandra Le Bras
-
FELASA2022 – Communication as a driver for better science, transparency, and animal welfare Lab Anim. (IF 9.667) Pub Date : 2022-08-10 Nuno Henrique Franco, Vootele Voikar
World-changing events took place between the 2019 and 2022 FELASA congresses. The challenges imposed by the Covid-19 pandemic highlighted the importance of animal research, and were an unavoidable issue discussed at FELASA2022. However, it was the future of laboratory animal science, medicine, and education that took central stage ─ a future that will rely on improved ‘Communication’ between all stakeholders
-
Use surplus laboratory animals as animal feed. Lab Anim. (IF 9.667) Pub Date : 2022-08-03 Katja Hose,Stefan Nagel-Riedasch,Johannes Schenkel,Thorsten Buch
-
Zebrafish shed light on regeneration research. Lab Anim. (IF 9.667) Pub Date : 2022-08-01 Ioannis Bakoyiannis
-
Mitochondria underlie the sex-bias in diastolic dysfunction. Lab Anim. (IF 9.667) Pub Date : 2022-08-01 Alexandra Le Bras
-
Sex differences in brain chromatin dynamics. Lab Anim. (IF 9.667) Pub Date : 2022-08-01 Alexandra Le Bras
-
Mapping neurons and cerebrovascular networks in mice. Lab Anim. (IF 9.667) Pub Date : 2022-08-01 Ioannis Bakoyiannis
-
A new resource to measure kidney dysfunction in zebrafish. Lab Anim. (IF 9.667) Pub Date : 2022-08-01 Ioannis Bakoyiannis
-
-
-
An assessment of ambient noise and other environmental variables in a nonhuman primate housing facility Lab Anim. (IF 9.667) Pub Date : 2022-07-27 Alexander R. McLeod, Jane A. Burton, Chase A. Mackey, Ramnarayan Ramachandran
-
More of a nightmare: metastasis accelerates during sleep. Lab Anim. (IF 9.667) Pub Date : 2022-08-01 Ioannis Bakoyiannis
-
Considering the non-specific effects of diphtheria toxin in cell-depletion studies. Lab Anim. (IF 9.667) Pub Date : 2022-08-01 Alexandra Le Bras
-
Addressing the current challenges of transporting laboratory rodents Lab Anim. (IF 9.667) Pub Date : 2022-07-07 Mila Kundu
Transporting lab rodents is increasingly complex, owing to a variety of global trends and current constraints. Best practices and innovative approaches can help to ensure lab animals reach their destination safely and in a timely way. This Comment reviews those challenges and best practices through the lab animal transportation experiences of Taconic Biosciences, a global provider of rodent models
-
Animal number versus maximum tumour volume: an example of reduction and refinement trade-off in the 3Rs Lab Anim. (IF 9.667) Pub Date : 2022-07-01 Dominique-Laurent Couturier, Henri G. M. J. Bertrand
-
Reducing cage effects in mouse microbiome studies. Lab Anim. (IF 9.667) Pub Date : 2022-07-01 Alexandra Le Bras
-
Noradrenaline facilitates task execution and optimization. Lab Anim. (IF 9.667) Pub Date : 2022-07-01 Ioannis Bakoyiannis
-
A previously unknown stressor for the lab male mice. Lab Anim. (IF 9.667) Pub Date : 2022-07-01 Alexandra Le Bras
-
-
What Constitutes Material Alteration of Behavior? Lab Anim. (IF 9.667) Pub Date : 2022-07-01 Robert S Sikes,L Michael Romero
-
The Goal Should Not Be To Find Loopholes In Coverage. Lab Anim. (IF 9.667) Pub Date : 2022-07-01 Daniel M Mulcahy
-
New insights into the origin of amyloid plaques. Lab Anim. (IF 9.667) Pub Date : 2022-07-01 Alexandra Le Bras
-
The genomic landscape of canine diffuse large B-cell lymphoma identifies distinct subtypes with clinical and therapeutic implications Lab Anim. (IF 9.667) Pub Date : 2022-06-20 Diana Giannuzzi, Laura Marconato, Antonella Fanelli, Luca Licenziato, Raffaella De Maria, Andrea Rinaldi, Luca Rotta, Nicole Rouquet, Giovanni Birolo, Piero Fariselli, Afua A. Mensah, Francesco Bertoni, Luca Aresu
-
CSF: a key player in brain's immunity. Lab Anim. (IF 9.667) Pub Date : 2022-07-01 Ioannis Bakoyiannis
-
Fkbp5-humanized mice shed light on female higher vulnerability to stress Lab Anim. (IF 9.667) Pub Date : 2022-06-09 Marie-Pierre Moisan
Single nucleotide polymorphisms in the FKBP5 gene influence the risk of developing stress-related disorders, but the underlying processes are not fully understood. Animal models offer a possibility to investigate the influence of FKBP5 gene variants on the stress response system.
-
3R measures in facilities for the production of genetically modified rodents Lab Anim. (IF 9.667) Pub Date : 2022-05-31 Branko Zevnik, Boris Jerchow, Thorsten Buch
Sociocultural changes in the human–animal relationship have led to increasing demands for animal welfare in biomedical research. The 3R concept is the basis for bringing this demand into practice: Replace animal experiments with alternatives where possible, Reduce the number of animals used to a scientifically justified minimum and Refine the procedure to minimize animal harm. The generation of gene-modified
-
-
Effect of e-cigarette inhalation on mouse organs. Lab Anim. (IF 9.667) Pub Date : 2022-06-01 Ioannis Bakoyiannis
-
Titan mice: a model for obesity research. Lab Anim. (IF 9.667) Pub Date : 2022-06-01 Alexandra Le Bras
-
The Matters of an Occupational Health and Safety Program. Lab Anim. (IF 9.667) Pub Date : 2022-06-01 Lauren Danridge,Bill Greer
-
-
Effectiveness and Consistency of Occupational Health Safety Programs. Lab Anim. (IF 9.667) Pub Date : 2022-06-01 Karl J Jepsen,Janet Follo,Danielle Sheen,Kevin Ferrell
-
A novel approach to study the effects of mutations on melanoma phenotype. Lab Anim. (IF 9.667) Pub Date : 2022-06-01 Alexandra Le Bras
-
Don’t forget the bacteriophages Lab Anim. (IF 9.667) Pub Date : 2022-05-13 Mercedes Gomez de Agüero, Aryan Rahimi-Midani
New insights into gut-brain axis and cognition function show that accumulation of Caudovirales bacteriophages in the gut microbiota is associated with improved executive function and memory.
-
Clarifying Clinical Trials and IACUC Oversight. Lab Anim. (IF 9.667) Pub Date : 2022-06-01 Lon V Kendall
-
Reply To: Clarifying Clinical Trials and IACUC Oversight. Lab Anim. (IF 9.667) Pub Date : 2022-06-01 Lauren Danridge,Bill Greer
-
New miniscope for large-scale in vivo calcium imaging. Lab Anim. (IF 9.667) Pub Date : 2022-05-01 Ioannis Bakoyiannis
-
Proteomic profiling of extracellular vesicles in C.elegans. Lab Anim. (IF 9.667) Pub Date : 2022-05-01 Alexandra Le Bras
-
A NHP model of congenital Zika virus infection. Lab Anim. (IF 9.667) Pub Date : 2022-05-01 Alexandra Le Bras
-
D. welbionis attenuates obesity and metabolic disorders. Lab Anim. (IF 9.667) Pub Date : 2022-05-01 Ioannis Bakoyiannis
-
Dampened inflammation drives cancer resistance in naked mole-rats. Lab Anim. (IF 9.667) Pub Date : 2022-05-01 Alexandra Le Bras
-
Opposite role of dopamine receptors in aging. Lab Anim. (IF 9.667) Pub Date : 2022-05-01 Ioannis Bakoyiannis
-
A new optogenetic-based system of α-syn aggregation. Lab Anim. (IF 9.667) Pub Date : 2022-05-01 Alexandra Le Bras
-
Protocol Compliance and Institutional Best Practices. Lab Anim. (IF 9.667) Pub Date : 2022-05-01 Austin Fritsch
-
Animal models of male subfertility targeted on LanCL1-regulated spermatogenic redox homeostasis Lab Anim. (IF 9.667) Pub Date : 2022-04-25 Chao Huang, Chengcheng Yang, Dejiang Pang, Chao Li, Huan Gong, Xiyue Cao, Xia He, Xueyao Chen, Bin Mu, Yiyuan Cui, Wentao Liu, Qihui Luo, Anchun Cheng, Lanlan Jia, Mina Chen, Bo Xiao, Zhengli Chen
Oxidative stress in spermatozoa is a major contributor to male subfertility, which makes it an informed choice to generate animal models of male subfertility with targeted modifications of the antioxidant systems. However, the critical male germ cell-specific antioxidant mechanisms have not been well defined yet. Here we identify LanCL1 as a major male germ cell-specific antioxidant gene, reduced expression
-
Gut microbiota drives disease variability in the DSS colitis mouse model. Lab Anim. (IF 9.667) Pub Date : 2022-05-01 Alexandra Le Bras
-
Targeting the eicosanoid pathway treats COVID-19 in middle-aged mice. Lab Anim. (IF 9.667) Pub Date : 2022-05-01 Ioannis Bakoyiannis
-
Role of astroglial glutamine in memory. Lab Anim. (IF 9.667) Pub Date : 2022-04-01 Ioannis Bakoyiannis
-
Exercise improves polyQ disease in flies. Lab Anim. (IF 9.667) Pub Date : 2022-04-01 Alexandra Le Bras
-
Sleep apnea during pregnancy affects brain development. Lab Anim. (IF 9.667) Pub Date : 2022-04-01 Alexandra Le Bras
-
Distinct neurons control complex movements in Drosophila. Lab Anim. (IF 9.667) Pub Date : 2022-04-01 Ioannis Bakoyiannis
-
The Collaborative Cross: a model for genetic variation in TB. Lab Anim. (IF 9.667) Pub Date : 2022-04-01 Alexandra Le Bras
-
Serotonin regulates sweet and bitter taste in Drosophila. Lab Anim. (IF 9.667) Pub Date : 2022-04-01 Ioannis Bakoyiannis
-
Two complementary neurotransmitters mediate decisions in monkeys. Lab Anim. (IF 9.667) Pub Date : 2022-04-01 Ioannis Bakoyiannis
-
-
Opportunity for an improved animal care program. Lab Anim. (IF 9.667) Pub Date : 2022-04-01 Gwen Waddingham,Mary Haun,Bethany Ahlers
-
Delaying the Inevitable: a Justified Means to an End? Lab Anim. (IF 9.667) Pub Date : 2022-04-01 Lauren Danridge,Bill Greer
-
In vivo potency assay for the screening of bioactive molecules on cartilage formation Lab Anim. (IF 9.667) Pub Date : 2022-03-31 Anne-Sophie Thorup, Sara Caxaria, Bethan L. Thomas, Yasir Suleman, Giovanna Nalesso, Frank P. Luyten, Francesco Dell’Accio, Suzanne E. Eldridge
Cartilage regeneration is a priority in medicine for the treatment of osteoarthritis and isolated cartilage defects. Several molecules with potential for cartilage regeneration are under investigation. Unfortunately, in vitro chondrogenesis assays do not always predict the stability of the newly formed cartilage in vivo. Therefore, there is a need for a stringent, quantifiable assay to assess in vivo
-
A Word from USDA and OLAW Lab Anim. (IF 9.667) Pub Date : 2022-03-31 Patricia Brown,Betty Goldentyer
-
Electroporation-based mouse models provide new insights into ovarian cancer and response to therapy. Lab Anim. (IF 9.667) Pub Date : 2022-04-01 Alexandra Le Bras