当前期刊: Nature Immunology Go to current issue    加入关注   
显示样式:        排序: IF: - GO 导出
我的关注
我的收藏
您暂时未登录!
登录
  • Author Correction: Tumor cells suppress radiation-induced immunity by hijacking caspase 9 signaling
    Nat. Immunol. (IF 20.479) Pub Date : 2020-09-16
    Chuanhui Han; Zhida Liu; Yunjia Zhang; Aijun Shen; Chunbo Dong; Anli Zhang; Casey Moore; Zhenhua Ren; Changzheng Lu; Xuezhi Cao; Chun-Li Zhang; Jian Qiao; Yang-Xin Fu

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

    更新日期:2020-09-16
  • Author Correction: STEEP mediates STING ER exit and activation of signaling
    Nat. Immunol. (IF 20.479) Pub Date : 2020-09-14
    Bao-cun Zhang; Ramya Nandakumar; Line S. Reinert; Jinrong Huang; Anders Laustsen; Zong-liang Gao; Cheng-long Sun; Søren Beck Jensen; Anne Troldborg; Sonia Assil; Martin F. Berthelsen; Carsten Scavenius; Yan Zhang; Samuel J. Windross; David Olagnier; Thaneas Prabakaran; Chiranjeevi Bodda; Ryo Narita; Yujia Cai; Cong-gang Zhang; Harald Stenmark; Christine M. Doucet; Takeshi Noda; Zheng Guo; Raphaela

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

    更新日期:2020-09-14
  • A regulatory T cell Notch4–GDF15 axis licenses tissue inflammation in asthma
    Nat. Immunol. (IF 20.479) Pub Date : 2020-09-14
    Hani Harb; Emmanuel Stephen-Victor; Elena Crestani; Mehdi Benamar; Amir Massoud; Ye Cui; Louis-Marie Charbonnier; Sena Arbag; Safa Baris; Amparito Cunnigham; Juan Manuel Leyva-Castillo; Raif S. Geha; Amirhosein J. Mousavi; Boris Guennewig; Klaus Schmitz-Abe; Constantinos Sioutas; Wanda Phipatanakul; Talal A. Chatila

    Elucidating the mechanisms that sustain asthmatic inflammation is critical for precision therapies. We found that interleukin-6- and STAT3 transcription factor-dependent upregulation of Notch4 receptor on lung tissue regulatory T (Treg) cells is necessary for allergens and particulate matter pollutants to promote airway inflammation. Notch4 subverted Treg cells into the type 2 and type 17 helper (TH2

    更新日期:2020-09-14
  • Meningeal γδ T cells regulate anxiety-like behavior via IL-17a signaling in neurons
    Nat. Immunol. (IF 20.479) Pub Date : 2020-09-14
    Kalil Alves de Lima; Justin Rustenhoven; Sandro Da Mesquita; Morgan Wall; Andrea Francesca Salvador; Igor Smirnov; Guilherme Martelossi Cebinelli; Tornike Mamuladze; Wendy Baker; Zach Papadopoulos; Maria Beatriz Lopes; William Sam Cao; Xinmin Simon Xie; Jasmin Herz; Jonathan Kipnis

    Interleukin (IL)-17a has been highly conserved during evolution of the vertebrate immune system and widely studied in contexts of infection and autoimmunity. Studies suggest that IL-17a promotes behavioral changes in experimental models of autism and aggregation behavior in worms. Here, through a cellular and molecular characterization of meningeal γδ17 T cells, we defined the nearest central nervous

    更新日期:2020-09-14
  • A dynamic CD2-rich compartment at the outer edge of the immunological synapse boosts and integrates signals
    Nat. Immunol. (IF 20.479) Pub Date : 2020-09-14
    Philippos Demetriou; Enas Abu-Shah; Salvatore Valvo; Sarah McCuaig; Viveka Mayya; Audun Kvalvaag; Thomas Starkey; Kseniya Korobchevskaya; Lennard Y. W. Lee; Matthias Friedrich; Elizabeth Mann; Mikhail A. Kutuzov; Matteo Morotti; Nina Wietek; Heather Rada; Shamsideen Yusuf; Jehan Afrose; Anastasios Siokis; Michael Meyer-Hermann; Ahmed Ashour Ahmed; David Depoil; Michael L. Dustin

    The CD2–CD58 recognition system promotes adhesion and signaling and counters exhaustion in human T cells. We found that CD2 localized to the outer edge of the mature immunological synapse, with cellular or artificial APC, in a pattern we refer to as a ‘CD2 corolla’. The corolla captured engaged CD28, ICOS, CD226 and SLAM-F1 co-stimulators. The corolla amplified active phosphorylated Src-family kinases

    更新日期:2020-09-14
  • Publisher Correction: Captain GBP1: inflammasomes assemble, pyroptotic endgame
    Nat. Immunol. (IF 20.479) Pub Date : 2020-09-10
    Shouya Feng; Si Ming Man

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

    更新日期:2020-09-10
  • T cells in COVID-19 — united in diversity
    Nat. Immunol. (IF 20.479) Pub Date : 2020-09-07
    Leo Swadling; Mala K. Maini

    Comprehensive mapping reveals that functional CD4+ and CD8+ T cells targeting multiple regions of SARS-CoV-2 are maintained in the resolution phase of both mild and severe COVID-19, and their magnitude correlates with the antibody response.

    更新日期:2020-09-08
  • Limited proliferation capacity of aortic intima resident macrophages requires monocyte recruitment for atherosclerotic plaque progression
    Nat. Immunol. (IF 20.479) Pub Date : 2020-09-07
    Jesse W. Williams; Konstantin Zaitsev; Ki-Wook Kim; Stoyan Ivanov; Brian T. Saunders; Patricia R. Schrank; Kyeongdae Kim; Andrew Elvington; Seung Hyeon Kim; Christopher G. Tucker; Mary Wohltmann; Brian T. Fife; Slava Epelman; Maxim N. Artyomov; Kory J. Lavine; Bernd H. Zinselmeyer; Jae-Hoon Choi; Gwendalyn J. Randolph

    Early atherosclerosis depends upon responses by immune cells resident in the intimal aortic wall. Specifically, the healthy intima is thought to be populated by vascular dendritic cells (DCs) that, during hypercholesterolemia, initiate atherosclerosis by being the first to accumulate cholesterol. Whether these cells remain key players in later stages of disease is unknown. Using murine lineage-tracing

    更新日期:2020-09-08
  • Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19.
    Nat. Immunol. (IF 20.479) Pub Date : 2020-09-04
    Yanchun Peng,Alexander J Mentzer,Guihai Liu,Xuan Yao,Zixi Yin,Danning Dong,Wanwisa Dejnirattisai,Timothy Rostron,Piyada Supasa,Chang Liu,César López-Camacho,Jose Slon-Campos,Yuguang Zhao,David I Stuart,Guido C Paesen,Jonathan M Grimes,Alfred A Antson,Oliver W Bayfield,Dorothy E D P Hawkins,De-Sheng Ker,Beibei Wang,Lance Turtle,Krishanthi Subramaniam,Paul Thomson,Ping Zhang,Christina Dold,Jeremy Ratcliff

    The development of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines and therapeutics will depend on understanding viral immunity. We studied T cell memory in 42 patients following recovery from COVID-19 (28 with mild disease and 14 with severe disease) and 16 unexposed donors, using interferon-γ-based assays with peptides spanning SARS-CoV-2 except ORF1. The breadth and magnitude

    更新日期:2020-09-05
  • Author Correction: Requirement for the basic helix-loop-helix transcription factor Dec2 in initial TH2 lineage commitment.
    Nat. Immunol. (IF 20.479) Pub Date : 2020-09-03
    Xuexian O Yang,Pornpimon Angkasekwinai,Jinfang Zhu,Juan Peng,Zhiduo Liu,Roza Nurieva,Xikui Liu,Yeonseok Chung,Seon Hee Chang,Bing Sun,Chen Dong

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

    更新日期:2020-09-03
  • Publisher Correction: SARS-CoV-2 infection of human ACE2-transgenic mice causes severe lung inflammation and impaired function.
    Nat. Immunol. (IF 20.479) Pub Date : 2020-09-02
    Emma S Winkler,Adam L Bailey,Natasha M Kafai,Sharmila Nair,Broc T McCune,Jinsheng Yu,Julie M Fox,Rita E Chen,James T Earnest,Shamus P Keeler,Jon H Ritter,Liang-I Kang,Sarah Dort,Annette Robichaud,Richard Head,Michael J Holtzman,Michael S Diamond

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

    更新日期:2020-09-02
  • Circulating TFH cells as a marker for early therapeutic intervention in T1D.
    Nat. Immunol. (IF 20.479) Pub Date : 2020-09-01
    Estelle Bettelli,Daniel J Campbell

    Costimulatory blockade via the CTLA-4–Ig fusion protein abatacept is beneficial in patients with early-onset type 1 diabetes, but some individuals benefit more than others. A new study reports that the pretreatment abundance of T follicular helper (TFH) cells could predict clinical responses to abatacept.

    更新日期:2020-09-01
  • NR4As apply brakes on the B cell response.
    Nat. Immunol. (IF 20.479) Pub Date : 2020-08-31
    Louisa Hill,Tanja A Schwickert

    To trigger an adequate humoral immune response while ensuring self-tolerance, B cell activation is tightly controlled. A new study indicates that an NR4A-enforced built-in brake fine-tunes the early phase of transcriptional reprogramming induced by BCR stimulation.

    更新日期:2020-08-31
  • NR4A nuclear receptors restrain B cell responses to antigen when second signals are absent or limiting.
    Nat. Immunol. (IF 20.479) Pub Date : 2020-08-31
    Corey Tan,Ryosuke Hiwa,James L Mueller,Vivasvan Vykunta,Kenta Hibiya,Mark Noviski,John Huizar,Jeremy F Brooks,Jose Garcia,Cheryl Heyn,Zhongmei Li,Alexander Marson,Julie Zikherman

    Antigen stimulation (signal 1) triggers B cell proliferation and primes B cells to recruit, engage and respond to T cell help (signal 2). Failure to receive signal 2 within a defined time window results in B cell apoptosis, yet the mechanisms that enforce dependence on co-stimulation are incompletely understood. Nr4a1–3 encode a small family of orphan nuclear receptors that are rapidly induced by B

    更新日期:2020-08-31
  • Dynamic regulation of hypoxia-inducible factor-1α activity is essential for normal B cell development.
    Nat. Immunol. (IF 20.479) Pub Date : 2020-08-31
    Natalie Burrows,Rachael J M Bashford-Rogers,Vijesh J Bhute,Ana Peñalver,John R Ferdinand,Benjamin J Stewart,Joscelin E G Smith,Mukta Deobagkar-Lele,Girolamo Giudice,Thomas M Connor,Akimichi Inaba,Laura Bergamaschi,Sam Smith,Maxine G B Tran,Evangelia Petsalaki,Paul A Lyons,Marion Espeli,Brian J P Huntly,Kenneth G C Smith,Richard J Cornall,Menna R Clatworthy,Patrick H Maxwell

    B lymphocyte development and selection are central to adaptive immunity and self-tolerance. These processes require B cell receptor (BCR) signaling and occur in bone marrow, an environment with variable hypoxia, but whether hypoxia-inducible factor (HIF) is involved is unknown. We show that HIF activity is high in human and murine bone marrow pro-B and pre-B cells and decreases at the immature B cell

    更新日期:2020-08-31
  • The PD-1 expression balance between effector and regulatory T cells predicts the clinical efficacy of PD-1 blockade therapies.
    Nat. Immunol. (IF 20.479) Pub Date : 2020-08-31
    Shogo Kumagai,Yosuke Togashi,Takahiro Kamada,Eri Sugiyama,Hitomi Nishinakamura,Yoshiko Takeuchi,Kochin Vitaly,Kota Itahashi,Yuka Maeda,Shigeyuki Matsui,Takuma Shibahara,Yasuho Yamashita,Takuma Irie,Ayaka Tsuge,Shota Fukuoka,Akihito Kawazoe,Hibiki Udagawa,Keisuke Kirita,Keiju Aokage,Genichiro Ishii,Takeshi Kuwata,Kenta Nakama,Masahito Kawazu,Toshihide Ueno,Naoya Yamazaki,Koichi Goto,Masahiro Tsuboi

    Immune checkpoint blockade has provided a paradigm shift in cancer therapy, but the success of this approach is very variable; therefore, biomarkers predictive of clinical efficacy are urgently required. Here, we show that the frequency of PD-1+CD8+ T cells relative to that of PD-1+ regulatory T (Treg) cells in the tumor microenvironment can predict the clinical efficacy of programmed cell death protein

    更新日期:2020-08-31
  • Author Correction: ORF8 and ORF3b antibodies are accurate serological markers of early and late SARS-CoV-2 infection.
    Nat. Immunol. (IF 20.479) Pub Date : 2020-08-27
    Asmaa Hachim,Niloufar Kavian,Carolyn A Cohen,Alex W H Chin,Daniel K W Chu,Chris K P Mok,Owen T Y Tsang,Yiu Cheong Yeung,Ranawaka A P M Perera,Leo L M Poon,J S Malik Peiris,Sophie A Valkenburg

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

    更新日期:2020-08-27
  • Inflammation brakes mitochondrial metabolism in obesity.
    Nat. Immunol. (IF 20.479) Pub Date : 2020-08-27
    Nektarios Tavernarakis

    A vicious cycle, linking obesity with chronic inflammation, fuels the development and exacerbation of metabolic syndrome and other disorders. Modulation of mitochondrial energy metabolism via interleukin-1β signaling establishes a runaway positive-feedback loop that brings about and reinforces the sequelae of a high-fat diet.

    更新日期:2020-08-27
  • The dynamic changes in cytokine responses in COVID-19: a snapshot of the current state of knowledge.
    Nat. Immunol. (IF 20.479) Pub Date : 2020-08-27
    Maja Buszko,Jung-Hyun Park,Daniela Verthelyi,Ranjan Sen,Howard A Young,Amy S Rosenberg

    “The role of cytokines in COVID-19” online symposium was presented on 18 June 2020 by the NIH/FDA Immunology and Cytokine Interest Groups and was purposed to discuss our rapidly changing understanding of COVID-19-related cytokine responses in different stages of infection, including the etiologies, downstream consequences and possible mitigation strategies. The recording is available at https://nci

    更新日期:2020-08-27
  • NKG7 makes a better killer.
    Nat. Immunol. (IF 20.479) Pub Date : 2020-08-24
    Subramaniam Malarkannan

    New studies suggest that NKG7 is essential for NK and CD8+ T cell cytotoxic degranulation and CD4+ T cell activation and proinflammatory responses. While the mechanism is yet to be determined, the functional relevance is exciting and opens the possibility of a new target for cellular immunotherapies.

    更新日期:2020-08-24
  • The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation.
    Nat. Immunol. (IF 20.479) Pub Date : 2020-08-24
    Susanna S Ng,Fabian De Labastida Rivera,Juming Yan,Dillon Corvino,Indrajit Das,Ping Zhang,Rachel Kuns,Shashi Bhushan Chauhan,Jiajie Hou,Xian-Yang Li,Teija C M Frame,Benjamin A McEnroe,Eilish Moore,Jinrui Na,Jessica A Engel,Megan S F Soon,Bhawana Singh,Andrew J Kueh,Marco J Herold,Marcela Montes de Oca,Siddharth Sankar Singh,Patrick T Bunn,Amy Roman Aguilera,Mika Casey,Matthias Braun,Nazanin Ghazanfari

    Immune-modulating therapies have revolutionized the treatment of chronic diseases, particularly cancer. However, their success is restricted and there is a need to identify new therapeutic targets. Here, we show that natural killer cell granule protein 7 (NKG7) is a regulator of lymphocyte granule exocytosis and downstream inflammation in a broad range of diseases. NKG7 expressed by CD4+ and CD8+ T

    更新日期:2020-08-24
  • Fibroblasts as a source of self-antigens for central immune tolerance.
    Nat. Immunol. (IF 20.479) Pub Date : 2020-08-24
    Takeshi Nitta,Masanori Tsutsumi,Sachiko Nitta,Ryunosuke Muro,Emma C Suzuki,Kenta Nakano,Yoshihiko Tomofuji,Shinichiro Sawa,Tadashi Okamura,Josef M Penninger,Hiroshi Takayanagi

    Fibroblasts are one of the most common but also neglected types of stromal cells, the heterogeneity of which underlies the specific function of tissue microenvironments in development and regeneration. In the thymus, autoreactive T cells are thought to be negatively selected by reference to the self-antigens expressed in medullary epithelial cells, but the contribution of other stromal cells to tolerance

    更新日期:2020-08-24
  • SARS-CoV-2 infection of human ACE2-transgenic mice causes severe lung inflammation and impaired function.
    Nat. Immunol. (IF 20.479) Pub Date : 2020-08-24
    Emma S Winkler,Adam L Bailey,Natasha M Kafai,Sharmila Nair,Broc T McCune,Jinsheng Yu,Julie M Fox,Rita E Chen,James T Earnest,Shamus P Keeler,Jon H Ritter,Liang-I Kang,Sarah Dort,Annette Robichaud,Richard Head,Michael J Holtzman,Michael S Diamond

    Although animal models have been evaluated for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, none have fully recapitulated the lung disease phenotypes seen in humans who have been hospitalized. Here, we evaluate transgenic mice expressing the human angiotensin I-converting enzyme 2 (ACE2) receptor driven by the cytokeratin-18 (K18) gene promoter (K18-hACE2) as a model of SARS-CoV-2

    更新日期:2020-08-24
  • Early precursor T cells establish and propagate T cell exhaustion in chronic infection.
    Nat. Immunol. (IF 20.479) Pub Date : 2020-08-24
    Daniel T Utzschneider,Sarah S Gabriel,David Chisanga,Renee Gloury,Patrick M Gubser,Ajithkumar Vasanthakumar,Wei Shi,Axel Kallies

    CD8+ T cells responding to chronic infections or tumors acquire an ‘exhausted’ state associated with elevated expression of inhibitory receptors, including PD-1, and impaired cytokine production. Exhausted T cells are continuously replenished by T cells with precursor characteristics that self-renew and depend on the transcription factor TCF1; however, their developmental requirements are poorly understood

    更新日期:2020-08-24
  • The angiocrine Rspondin3 instructs interstitial macrophage transition via metabolic-epigenetic reprogramming and resolves inflammatory injury.
    Nat. Immunol. (IF 20.479) Pub Date : 2020-08-24
    Bisheng Zhou,Lissette Magana,Zhigang Hong,Long Shuang Huang,Sreeparna Chakraborty,Yoshikazu Tsukasaki,Cary Huang,Li Wang,Anke Di,Balaji Ganesh,Xiaopei Gao,Jalees Rehman,Asrar B Malik

    Macrophages demonstrate remarkable plasticity that is essential for host defense and tissue repair. The tissue niche imprints macrophage identity, phenotype and function. The role of vascular endothelial signals in tailoring the phenotype and function of tissue macrophages remains unknown. The lung is a highly vascularized organ and replete with a large population of resident macrophages. We found

    更新日期:2020-08-24
  • Recollections of the discovery of promiscuous antigen expression in mTECs.
    Nat. Immunol. (IF 20.479) Pub Date : 2020-08-20
    Ludger Klein

    Whether and how thymic tolerance to tissue-restricted antigens (TRA) could be achieved posed a conundrum until Klein and colleagues discovered that medullary thymic epithelial cells were capable of bursts of TRA expression.

    更新日期:2020-08-20
  • Regulation and modulation of antitumor immunity in pancreatic cancer.
    Nat. Immunol. (IF 20.479) Pub Date : 2020-08-17
    Joshua Leinwand,George Miller

    Pancreatic ductal adenocarcinoma carries a dismal prognosis, and outcomes have improved little with modern therapeutics. Checkpoint-based immunotherapy has failed to elicit responses in the vast majority of patients with pancreatic cancer. Alongside tumor cell–intrinsic mechanisms associated with oncogenic KRAS-induced inflammation, the tolerogenic myeloid cell infiltrate has emerged as a critical

    更新日期:2020-08-17
  • Basophils prime group 2 innate lymphoid cells for neuropeptide-mediated inhibition.
    Nat. Immunol. (IF 20.479) Pub Date : 2020-08-17
    Juan M Inclan-Rico,John J Ponessa,Nuriban Valero-Pacheco,Christina M Hernandez,Chandler B Sy,Alexander D Lemenze,Aimee M Beaulieu,Mark C Siracusa

    Type 2 cytokine responses promote parasitic immunity and initiate tissue repair; however, they can also result in immunopathologies when not properly restricted. Although basophilia is recognized as a common feature of type 2 inflammation, the roles basophils play in regulating these responses are unknown. Here, we demonstrate that helminth-induced group 2 innate lymphoid cell (ILC2) responses are

    更新日期:2020-08-17
  • ORF8 and ORF3b antibodies are accurate serological markers of early and late SARS-CoV-2 infection.
    Nat. Immunol. (IF 20.479) Pub Date : 2020-08-17
    Asmaa Hachim,Niloufar Kavian,Carolyn A Cohen,Alex W H Chin,Daniel K W Chu,Chris K P Mok,Owen T Y Tsang,Yiu Cheong Yeung,Ranawaka A P M Perera,Leo L M Poon,J S Malik Peiris,Sophie A Valkenburg

    The SARS-CoV-2 virus emerged in December 2019 and has caused a worldwide pandemic due to the lack of any pre-existing immunity. Accurate serology testing is urgently needed to help diagnose infection, determine past exposure of populations and assess the response to a future vaccine. The landscape of antibody responses to SARS-CoV-2 is unknown. In this study, we utilized the luciferase immunoprecipitation

    更新日期:2020-08-17
  • Single-cell landscape of immunological responses in patients with COVID-19.
    Nat. Immunol. (IF 20.479) Pub Date : 2020-08-12
    Ji-Yuan Zhang,Xiang-Ming Wang,Xudong Xing,Zhe Xu,Chao Zhang,Jin-Wen Song,Xing Fan,Peng Xia,Jun-Liang Fu,Si-Yu Wang,Ruo-Nan Xu,Xiao-Peng Dai,Lei Shi,Lei Huang,Tian-Jun Jiang,Ming Shi,Yuxia Zhang,Alimuddin Zumla,Markus Maeurer,Fan Bai,Fu-Sheng Wang

    In coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, the relationship between disease severity and the host immune response is not fully understood. Here we performed single-cell RNA sequencing in peripheral blood samples of 5 healthy donors and 13 patients with COVID-19, including moderate, severe and convalescent cases. Through

    更新日期:2020-08-12
  • Author Correction: Novel Hexb-based tools for studying microglia in the CNS.
    Nat. Immunol. (IF 20.479) Pub Date : 2020-08-11
    Takahiro Masuda,Lukas Amann,Roman Sankowski,Ori Staszewski,Maximilian Lenz,Paolo D Errico,Nicolas Snaidero,Marta Joana Costa Jordão,Chotima Böttcher,Katrin Kierdorf,Steffen Jung,Josef Priller,Thomas Misgeld,Andreas Vlachos,Melanie Meyer-Luehmann,Klaus-Peter Knobeloch,Marco Prinz

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

    更新日期:2020-08-11
  • IL-1 induces mitochondrial translocation of IRAK2 to suppress oxidative metabolism in adipocytes.
    Nat. Immunol. (IF 20.479) Pub Date : 2020-08-10
    Hao Zhou,Han Wang,Minjia Yu,Rebecca C Schugar,Wen Qian,Fangqiang Tang,Weiwei Liu,Hui Yang,Ruth E McDowell,Junjie Zhao,Ji Gao,Ashok Dongre,Julie A Carman,Mei Yin,Judith A Drazba,Robert Dent,Christopher Hine,Yeong-Renn Chen,Jonathan D Smith,Paul L Fox,J Mark Brown,Xiaoxia Li

    Chronic inflammation is a common feature of obesity, with elevated cytokines such as interleukin-1 (IL-1) in the circulation and tissues. Here, we report an unconventional IL-1R–MyD88–IRAK2–PHB/OPA1 signaling axis that reprograms mitochondrial metabolism in adipocytes to exacerbate obesity. IL-1 induced recruitment of IRAK2 Myddosome to mitochondria outer membranes via recognition by TOM20, followed

    更新日期:2020-08-10
  • Hhex drives B cells down memory lane.
    Nat. Immunol. (IF 20.479) Pub Date : 2020-08-07
    Kim L Good-Jacobson,Joanna R Groom

    The combination of single-cell RNA-seq and in vivo CRISPR–Cas9 screens reveal a new circuit that directs germinal center B cells toward a memory B cell phenotype during viral infection.

    更新日期:2020-08-08
  • Make killers sweeter: targeting metabolic checkpoints of NK cells.
    Nat. Immunol. (IF 20.479) Pub Date : 2020-08-03
    Haiming Wei,Binqing Fu

    Group 2 innate lymphoid cells (ILC2s) closely intersect with antitumor immunity. A new study describes how activation of lung-resident ILC2s orchestrates the suppression of natural killer cell–mediated innate antitumor immunity via an eosinophil-mediated metabolic mechanism.

    更新日期:2020-08-03
  • ILC2-driven innate immune checkpoint mechanism antagonizes NK cell antimetastatic function in the lung.
    Nat. Immunol. (IF 20.479) Pub Date : 2020-08-03
    Martijn J Schuijs,Shaun Png,Arianne C Richard,Anastasia Tsyben,Gregory Hamm,Julie Stockis,Celine Garcia,Silvain Pinaud,Ashley Nicholls,Xavier Romero Ros,Jing Su,Matthew D Eldridge,Angela Riedel,Eva M Serrao,Hans-Reimer Rodewald,Matthias Mack,Jacqueline D Shields,E Suzanne Cohen,Andrew N J McKenzie,Richard J A Goodwin,Kevin M Brindle,John C Marioni,Timotheus Y F Halim

    Metastasis constitutes the primary cause of cancer-related deaths, with the lung being a commonly affected organ. We found that activation of lung-resident group 2 innate lymphoid cells (ILC2s) orchestrated suppression of natural killer (NK) cell-mediated innate antitumor immunity, leading to increased lung metastases and mortality. Using multiple models of lung metastasis, we show that interleukin

    更新日期:2020-08-03
  • Mapping systemic lupus erythematosus heterogeneity at the single-cell level.
    Nat. Immunol. (IF 20.479) Pub Date : 2020-08-03
    Djamel Nehar-Belaid,Seunghee Hong,Radu Marches,Guo Chen,Mohan Bolisetty,Jeanine Baisch,Lynnette Walters,Marilynn Punaro,Robert J Rossi,Cheng-Han Chung,Richie P Huynh,Prashant Singh,William F Flynn,Joy-Ann Tabanor-Gayle,Navya Kuchipudi,Asuncion Mejias,Magalie A Collet,Anna Lisa Lucido,Karolina Palucka,Paul Robson,Santhanam Lakshminarayanan,Octavio Ramilo,Tracey Wright,Virginia Pascual,Jacques F Banchereau

    Patients with systemic lupus erythematosus (SLE) display a complex blood transcriptome whose cellular origin is poorly resolved. Using single-cell RNA sequencing, we profiled ~276,000 peripheral blood mononuclear cells from 33 children with SLE with different degrees of disease activity and 11 matched controls. Increased expression of interferon-stimulated genes (ISGs) distinguished cells from children

    更新日期:2020-08-03
  • The mesenchymal context in inflammation, immunity and cancer.
    Nat. Immunol. (IF 20.479) Pub Date : 2020-08-03
    Vasiliki Koliaraki,Alejandro Prados,Marietta Armaka,George Kollias

    Mesenchymal cells are mesoderm-derived stromal cells that are best known for providing structural support to organs, synthesizing and remodeling the extracellular matrix (ECM) and regulating development, homeostasis and repair of tissues. Recent detailed mechanistic insights into the biology of fibroblastic mesenchymal cells have revealed they are also significantly involved in immune regulation, stem

    更新日期:2020-08-03
  • In situ neutrophil efferocytosis shapes T cell immunity to influenza infection.
    Nat. Immunol. (IF 20.479) Pub Date : 2020-08-03
    Kihong Lim,Tae-Hyoun Kim,Alissa Trzeciak,Andrea M Amitrano,Emma C Reilly,Hen Prizant,Deborah J Fowell,David J Topham,Minsoo Kim

    Early recruitment of neutrophils from the blood to sites of tissue infection is a hallmark of innate immune responses. However, little is known about the mechanisms by which apoptotic neutrophils are cleared in infected tissues during resolution and the immunological consequences of in situ efferocytosis. Using intravital multiphoton microscopy, we show previously unrecognized motility patterns of

    更新日期:2020-08-03
  • Mitochondrial DNA drives abscopal responses to radiation that are inhibited by autophagy.
    Nat. Immunol. (IF 20.479) Pub Date : 2020-08-03
    Takahiro Yamazaki,Alexander Kirchmair,Ai Sato,Aitziber Buqué,Marissa Rybstein,Giulia Petroni,Norma Bloy,Francesca Finotello,Lena Stafford,Esther Navarro Manzano,Francisco Ayala de la Peña,Elena García-Martínez,Silvia C Formenti,Zlatko Trajanoski,Lorenzo Galluzzi

    Autophagy supports both cellular and organismal homeostasis. However, whether autophagy should be inhibited or activated for cancer therapy remains unclear. Deletion of essential autophagy genes increased the sensitivity of mouse mammary carcinoma cells to radiation therapy in vitro and in vivo (in immunocompetent syngeneic hosts). Autophagy-deficient cells secreted increased amounts of type I interferon

    更新日期:2020-08-03
  • Follicular helper T cell profiles predict response to costimulation blockade in type 1 diabetes.
    Nat. Immunol. (IF 20.479) Pub Date : 2020-08-03
    Natalie M Edner,Frank Heuts,Niclas Thomas,Chun Jing Wang,Lina Petersone,Rupert Kenefeck,Alexandros Kogimtzis,Vitalijs Ovcinnikovs,Ellen M Ross,Elisavet Ntavli,Yassin Elfaki,Martin Eichmann,Roman Baptista,Philip Ambery,Lutz Jermutus,Mark Peakman,Miranda Rosenthal,Lucy S K Walker

    Follicular helper T (TFH) cells are implicated in type 1 diabetes (T1D), and their development has been linked to CD28 costimulation. We tested whether TFH cells were decreased by costimulation blockade using the CTLA-4–immunoglobulin (Ig) fusion protein (abatacept) in a mouse model of diabetes and in individuals with new-onset T1D. Unbiased bioinformatics analysis identified that inducible costimulatory

    更新日期:2020-08-03
  • NRP1 cripples immunological memory.
    Nat. Immunol. (IF 20.479) Pub Date : 2020-07-28
    Nandini Acharya,Ana C Anderson

    Durable responses to immunotherapy require the development of robust CD8+ T cell memory. A new study indicates that NRP1 differs from other checkpoint receptors as it functions as a checkpoint for the generation of memory.

    更新日期:2020-07-28
  • A bacteria-chemokine double act repairs the skin.
    Nat. Immunol. (IF 20.479) Pub Date : 2020-07-27
    Vinod Nadella,Keisuke Nagao

    A complex formed by the chemokine CXCL10 and commensal skin microbiota–derived DNA is a crucial component that triggers type I IFN responses to facilitate skin repair.

    更新日期:2020-07-27
  • Single-cell transcriptome profiling reveals neutrophil heterogeneity in homeostasis and infection.
    Nat. Immunol. (IF 20.479) Pub Date : 2020-07-27
    Xuemei Xie,Qiang Shi,Peng Wu,Xiaoyu Zhang,Hiroto Kambara,Jiayu Su,Hongbo Yu,Shin-Young Park,Rongxia Guo,Qian Ren,Sudong Zhang,Yuanfu Xu,Leslie E Silberstein,Tao Cheng,Fengxia Ma,Cheng Li,Hongbo R Luo

    The full neutrophil heterogeneity and differentiation landscape remains incompletely characterized. Here, we profiled >25,000 differentiating and mature mouse neutrophils using single-cell RNA sequencing to provide a comprehensive transcriptional landscape of neutrophil maturation, function and fate decision in their steady state and during bacterial infection. Eight neutrophil populations were defined

    更新日期:2020-07-27
  • Distinct and temporary-restricted epigenetic mechanisms regulate human αβ and γδ T cell development.
    Nat. Immunol. (IF 20.479) Pub Date : 2020-07-27
    Juliette Roels,Anna Kuchmiy,Matthias De Decker,Steven Strubbe,Marieke Lavaert,Kai Ling Liang,Georges Leclercq,Bart Vandekerckhove,Filip Van Nieuwerburgh,Pieter Van Vlierberghe,Tom Taghon

    The development of TCRαβ and TCRγδ T cells comprises a step-wise process in which regulatory events control differentiation and lineage outcome. To clarify these mechanisms, we employed RNA-sequencing, ATAC–sequencing and ChIPmentation on well-defined thymocyte subsets that represent the continuum of human T cell development. The chromatin accessibility dynamics show clear stage specificity and reveal

    更新日期:2020-07-27
  • The transcription factor BCL-6 controls early development of innate-like T cells.
    Nat. Immunol. (IF 20.479) Pub Date : 2020-07-27
    Marianthi Gioulbasani,Alexandros Galaras,Sofia Grammenoudi,Panagiotis Moulos,Alexander L Dent,Mikael Sigvardsson,Pantelis Hatzis,Barbara L Kee,Mihalis Verykokakis

    Innate T cells, including invariant natural killer T (iNKT) and mucosal-associated innate T (MAIT) cells, are a heterogeneous T lymphocyte population with effector properties preprogrammed during their thymic differentiation. How this program is initiated is currently unclear. Here, we show that the transcription factor BCL-6 was transiently expressed in iNKT cells upon exit from positive selection

    更新日期:2020-07-27
  • Captain GBP1: inflammasomes assemble, pyroptotic endgame.
    Nat. Immunol. (IF 20.479) Pub Date : 2020-07-22
    Shouya Feng,Si Ming Man

    Guanylate-binding proteins (GBPs) promote immune defenses against infectious agents. Two studies reveal that GBP1 directly binds to cytosolic lipopolysaccharide (LPS), bringing caspase-4 to the surface of bacteria to induce pyroptosis.

    更新日期:2020-07-22
  • The activation trajectory of plasmacytoid dendritic cells in vivo during a viral infection.
    Nat. Immunol. (IF 20.479) Pub Date : 2020-07-20
    Abdenour Abbas,Thien-Phong Vu Manh,Michael Valente,Nils Collinet,Noudjoud Attaf,Chuang Dong,Karima Naciri,Rabie Chelbi,Geoffray Brelurut,Inaki Cervera-Marzal,Benjamin Rauwel,Jean-Luc Davignon,Gilles Bessou,Morgane Thomas-Chollier,Denis Thieffry,Alexandra-Chloé Villani,Pierre Milpied,Marc Dalod,Elena Tomasello

    Plasmacytoid dendritic cells (pDCs) are a major source of type I interferon (IFN-I). What other functions pDCs exert in vivo during viral infections is controversial, and more studies are needed to understand their orchestration. In the present study, we characterize in depth and link pDC activation states in animals infected by mouse cytomegalovirus by combining Ifnb1 reporter mice with flow cytometry

    更新日期:2020-07-20
  • Noncanonical binding of Lck to CD3ε promotes TCR signaling and CAR function.
    Nat. Immunol. (IF 20.479) Pub Date : 2020-07-20
    Frederike A Hartl,Esmeralda Beck-Garcìa,Nadine M Woessner,Lea J Flachsmann,Rubí M-H Velasco Cárdenas,Simon M Brandl,Sanaz Taromi,Gina J Fiala,Anna Morath,Pankaj Mishra,O Sascha Yousefi,Julia Zimmermann,Nico Hoefflin,Maja Köhn,Birgitta M Wöhrl,Robert Zeiser,Kristian Schweimer,Stefan Günther,Wolfgang W Schamel,Susana Minguet

    Initiation of T cell antigen receptor (TCR) signaling involves phosphorylation of CD3 cytoplasmic tails by the tyrosine kinase Lck. How Lck is recruited to the TCR to initiate signaling is not well known. We report a previously unknown binding motif in the CD3ε cytoplasmic tail that interacts in a noncanonical mode with the Lck SH3 domain: the receptor kinase (RK) motif. The RK motif is accessible

    更新日期:2020-07-20
  • The NK cell-cancer cycle: advances and new challenges in NK cell-based immunotherapies.
    Nat. Immunol. (IF 20.479) Pub Date : 2020-07-20
    Tobias Bald,Matthew F Krummel,Mark J Smyth,Kevin C Barry

    Natural killer (NK) cells belong to the innate immune system and contribute to protecting the host through killing of infected, foreign, stressed or transformed cells. Additionally, via cellular cross-talk, NK cells orchestrate antitumor immune responses. Hence, significant efforts have been undertaken to exploit the therapeutic properties of NK cells in cancer. Current strategies in preclinical and

    更新日期:2020-07-20
  • STEEP mediates STING ER exit and activation of signaling.
    Nat. Immunol. (IF 20.479) Pub Date : 2020-07-20
    Bao-Cun Zhang,Ramya Nandakumar,Line S Reinert,Jinrong Huang,Anders Laustsen,Zong-Liang Gao,Cheng-Long Sun,Søren Beck Jensen,Anne Troldborg,Sonia Assil,Martin F Berthelsen,Carsten Scavenius,Yan Zhang,Samuel J Windross,David Olagnier,Thaneas Prabakaran,Chiranjeevi Bodda,Ryo Narita,Yujia Cai,Cong-Gang Zhang,Harald Stenmark,Christine M Doucet,Takeshi Noda,Zheng Guo,Raphaela Goldbach-Mansky,Rune Hartmann

    STING is essential for control of infections and for tumor immunosurveillance, but it can also drive pathological inflammation. STING resides on the endoplasmic reticulum (ER) and traffics following stimulation to the ERGIC/Golgi, where signaling occurs. Although STING ER exit is the rate-limiting step in STING signaling, the mechanism that drives this process is not understood. Here we identify STEEP

    更新日期:2020-07-20
  • Publisher Correction: The discovery of human TSLP as a critical epithelial cytokine in type 2 immunity and allergic disease.
    Nat. Immunol. (IF 20.479) Pub Date : 2020-07-17
    Vassili Soumelis,Yong-Jun Liu

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

    更新日期:2020-07-17
  • Author Correction: Transcriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation.
    Nat. Immunol. (IF 20.479) Pub Date : 2020-07-13
    Andrew S Mendiola,Jae Kyu Ryu,Sophia Bardehle,Anke Meyer-Franke,Kenny Kean-Hooi Ang,Chris Wilson,Kim M Baeten,Kristina Hanspers,Mario Merlini,Sean Thomas,Mark A Petersen,Alexander Williams,Reuben Thomas,Victoria A Rafalski,Rosa Meza-Acevedo,Reshmi Tognatta,Zhaoqi Yan,Samuel J Pfaff,Michael R Machado,Catherine Bedard,Pamela E Rios Coronado,Xiqian Jiang,Jin Wang,Michael A Pleiss,Ari J Green,Scott S Zamvil

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

    更新日期:2020-07-13
  • Neuropilin-1 is a T cell memory checkpoint limiting long-term antitumor immunity.
    Nat. Immunol. (IF 20.479) Pub Date : 2020-07-13
    Chang Liu,Ashwin Somasundaram,Sasikanth Manne,Angela M Gocher,Andrea L Szymczak-Workman,Kate M Vignali,Ellen N Scott,Daniel P Normolle,E John Wherry,Evan J Lipson,Robert L Ferris,Tullia C Bruno,Creg J Workman,Dario A A Vignali

    Robust CD8+ T cell memory is essential for long-term protective immunity but is often compromised in cancer, where T cell exhaustion leads to loss of memory precursors. Immunotherapy via checkpoint blockade may not effectively reverse this defect, potentially underlying disease relapse. Here we report that mice with a CD8+ T cell–restricted neuropilin-1 (NRP1) deletion exhibited substantially enhanced

    更新日期:2020-07-13
  • The commensal skin microbiota triggers type I IFN-dependent innate repair responses in injured skin.
    Nat. Immunol. (IF 20.479) Pub Date : 2020-07-13
    Jeremy Di Domizio,Cyrine Belkhodja,Pauline Chenuet,Anissa Fries,Timothy Murray,Paula Marcos Mondéjar,Olivier Demaria,Curdin Conrad,Bernhard Homey,Sabine Werner,Daniel E Speiser,Bernhard Ryffel,Michel Gilliet

    Skin wounds heal by coordinated induction of inflammation and tissue repair, but the initiating events are poorly defined. Here we uncover a fundamental role of commensal skin microbiota in this process and show that it is mediated by the recruitment and the activation of type I interferon (IFN)-producing plasmacytoid DC (pDC). Commensal bacteria colonizing skin wounds trigger activation of neutrophils

    更新日期:2020-07-13
  • Impaired mitochondrial oxidative phosphorylation limits the self-renewal of T cells exposed to persistent antigen.
    Nat. Immunol. (IF 20.479) Pub Date : 2020-07-13
    Santosha A Vardhana,Madeline A Hwee,Mirela Berisa,Daniel K Wells,Kathryn E Yost,Bryan King,Melody Smith,Pamela S Herrera,Howard Y Chang,Ansuman T Satpathy,Marcel R M van den Brink,Justin R Cross,Craig B Thompson

    The majority of tumor-infiltrating T cells exhibit a terminally exhausted phenotype, marked by a loss of self-renewal capacity. How repetitive antigenic stimulation impairs T cell self-renewal remains poorly defined. Here, we show that persistent antigenic stimulation impaired ADP-coupled oxidative phosphorylation. The resultant bioenergetic compromise blocked proliferation by limiting nucleotide triphosphate

    更新日期:2020-07-13
  • Tissue-resident memory CD8+ T cells shape local and systemic secondary T cell responses.
    Nat. Immunol. (IF 20.479) Pub Date : 2020-07-13
    Felix M Behr,Loreto Parga-Vidal,Natasja A M Kragten,Teunis J P van Dam,Thomas H Wesselink,Brian S Sheridan,Ramon Arens,Rene A W van Lier,Regina Stark,Klaas P J M van Gisbergen

    Tissue-resident memory CD8+ T cells (TRM cells) are crucial in protecting against reinvading pathogens, but the impact of reinfection on their tissue confinement and contribution to recall responses is unclear. We developed a unique lineage tracer mouse model exploiting the TRM-defining transcription factor homolog of Blimp-1 in T cells (Hobit) to fate map the TRM progeny in secondary responses. After

    更新日期:2020-07-13
  • Engineered T cells Flt around their targets.
    Nat. Immunol. (IF 20.479) Pub Date : 2020-07-09
    Emma C Morris

    Antigen escape by solid tumors has limited the efficacy of genetically modified T cells. T cells engineered to secrete the cytokine Flt3L induce the activation of endogenous T cells, enabling a broader repertoire of tumor antigens to be targeted via the expansion of intratumoral antigen presenting cells, significantly improving tumor responses.

    更新日期:2020-07-09
  • Author Correction: The immunology of blood: connecting the dots at the neurovascular interface.
    Nat. Immunol. (IF 20.479) Pub Date : 2020-07-07
    Katerina Akassoglou

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

    更新日期:2020-07-07
  • CARs need a jump start to get going.
    Nat. Immunol. (IF 20.479) Pub Date : 2020-07-06
    Björn F Lillemeier

    CAR T cells are engineered to recognize tumor-specific antigens and kill tumor cells. A study of CAR T cell activation using single-molecule microscopy reveals that CARs fail to efficiently convert antigen binding into early T cell signaling events.

    更新日期:2020-07-06
  • The active inner life of naive T cells.
    Nat. Immunol. (IF 20.479) Pub Date : 2020-07-06
    Julia M Marchingo,Doreen A Cantrell

    Quantitative systems-level proteomics is cleverly used to reveal a dynamic program of protein turnover in naive and memory CD4+ T cells that, alongside a stockpile of metabolic protein machinery, poises the cells for activation.

    更新日期:2020-07-06