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GFI1-driven transcriptional and epigenetic programs maintain CD8+ T cell stemness and persistence Nat. Immunol. (IF 27.7) Pub Date : 2025-05-15 M. Zeeshan Chaudhry, Evelyn Chen, Hiu On Man, Aneesha Jones, Renae Denman, Huiyang Yu, Qiutong Huang, Adrian Ilich, Jaring Schreuder, Severine Navarro, Zewen K. Tuong, Gabrielle T. Belz
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Mucosal unadjuvanted booster vaccines elicit local IgA responses by conversion of pre-existing immunity in mice Nat. Immunol. (IF 27.7) Pub Date : 2025-05-13 Dong-il Kwon, Tianyang Mao, Benjamin Israelow, Keyla Santos Guedes de Sá, Huiping Dong, Akiko Iwasaki
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Inhibition of ENT1 relieves intracellular adenosine-mediated T cell suppression in cancer Nat. Immunol. (IF 27.7) Pub Date : 2025-05-12 Theodore J. Sanders, Christopher S. Nabel, Margreet Brouwer, Annelise L. Hermant, Lucas Chaible, Jean-Philippe Deglasse, Nicolas Rosewick, Angélique Pabois, Wilfried Cathou, Aurore Smets, Michael Deligny, João Marchante, Quentin Dubray, Marie-Claire Letellier, Chiara Martinoli, Reece Marillier, Olivier De Henau, Yvonne McGrath, Matthew G. Vander Heiden, Erica Houthuys
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Cutaneous T cell immunity Nat. Immunol. (IF 27.7) Pub Date : 2025-05-07 Pirooz Zareie, Eric S. Weiss, Daniel H. Kaplan, Laura K. Mackay
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Immune–epithelial–stromal networks define the cellular ecosystem of the small intestine in celiac disease Nat. Immunol. (IF 27.7) Pub Date : 2025-05-06 Michael E. B. FitzPatrick, Agne Antanaviciute, Melanie Dunstan, Karolina Künnapuu, Dominik Trzupek, Nicholas M. Provine, Kyla Dooley, Jia-Yuan Zhang, Sophie L. Irwin, Lucy C. Garner, Jane I. Pernes, Ricardo C. Ferreira, Sarah C. Sasson, Dominik Aschenbrenner, Devika Agarwal, Astor Rodrigues, Lucy Howarth, Oliver Brain, Darren Ruane, Elizabeth Soilleux, Sarah A. Teichmann, Calliope A. Dendrou, Alison
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IgA clears gut viruses Nat. Immunol. (IF 27.7) Pub Date : 2025-04-30 Paula Jauregui
Secretory IgA coats the intestinal microbiota and is the most abundant antibody isotype produced in the mammalian gastrointestinal mucosa. In Cell Host and Microbe, Lisicka et al. show that IgA prevents chronic gut colonization by viruses and that IgA deficiency in some individuals increases susceptibility to colitis if exposed to viral pathobionts. The authors designed a mouse model of secretory IgA
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Short-range immunity Nat. Immunol. (IF 27.7) Pub Date : 2025-04-30 Ioana Staicu
The double-stranded RNA (dsRNA) sensor 2′,5′-oligoadenylate synthetase (OAS) produces the linear oligonucleotide 2-5A, which binds to and activates RNase L to cleave host and viral RNA and activate RIG-I-like receptors. In Immunity, Yan and colleagues show that 2-5A is transferred from cell to cell through gap junctions to mediate short-range communication between cells during infection and cancer
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Skin–gut crosstalk Nat. Immunol. (IF 27.7) Pub Date : 2025-04-30 Nicholas J. Bernard
Skin damage can have systemic effects but whether it can result in the priming of immune responses that are spatially removed from the skin is less clear. Data now published in Science Immunology show that cytokines released from damaged skin can function as endocrine adjuvants to prime normally tolerogenic gastrointestinal immune responses to the model food antigen ovalbumin, thereby driving humoral
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Treg cells control female nociception Nat. Immunol. (IF 27.7) Pub Date : 2025-04-30 Stephanie Houston
Women experience a higher prevalence of chronic pain, and pain hypersensitivity has been observed in female mice, but that mechanisms that drive sexual dimorphism in nociception remain unclear. In Science, Midavaine et al. find that meningeal regulatory T (mTreg) cells controlled the responses of female mice to mechanical pain via the endogenous opioid peptide enkephalin. Intrathecal injection of pegylated
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Unravelling the interplay between respiratory disease and the immune landscape in long COVID Nat. Immunol. (IF 27.7) Pub Date : 2025-04-30 James A. Harker, Ryan S. Thwaites
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Gut T cell plasticity generates pathogenic TFH cells that promote systemic autoimmunity Nat. Immunol. (IF 27.7) Pub Date : 2025-04-30
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Stepwise neofunctionalization of the NF-κB family member Rel during vertebrate evolution Nat. Immunol. (IF 27.7) Pub Date : 2025-04-30 Allison E. Daly, Abraham B. Chang, Prabhat K. Purbey, Kevin J. Williams, Shuxing Li, Benjamin D. Redelings, George Yeh, Yongqing Wu, Scott D. Pope, Byrappa Venkatesh, Sibon Li, Kaylin Nguyen, Joseph Rodrigues, Kelsey Jorgensen, Ananya Dasgupta, Trevor Siggers, Lin Chen, Stephen T. Smale
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Aberrant T follicular helper cells generated by TH17 cell plasticity in the gut promote extraintestinal autoimmunity Nat. Immunol. (IF 27.7) Pub Date : 2025-04-30 Tingting Fan, Chi Tai, Kiah C. Sleiman, Madeline P. Cutcliffe, Haram Kim, Ye Liu, Jianying Li, Gang Xin, Mollyanna Grashel, Laurie Baert, Chinwe Ekeocha, Paige Vergenes, Svetlana Lima, Wan-Lin Lo, Judith Lin, Beatriz Hanaoka, Trevor N. Tankersley, Min Wang, Xuan Zhang, George C. Tsokos, Wael Jarjour, Randy Longman, Hsin-Jung Joyce Wu
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Cholinergic T cells revitalize the tumor immune microenvironment: TIME to ChAT Nat. Immunol. (IF 27.7) Pub Date : 2025-04-30 Chunxing Zheng, Shaofeng Liu, Nastaran Fazel Modares, Michael St. Paul, Tak W. Mak
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Identification of soluble biomarkers that associate with distinct manifestations of long COVID Nat. Immunol. (IF 27.7) Pub Date : 2025-04-30 Yu Gao, Curtis Cai, Sarah Adamo, Elsa Biteus, Habiba Kamal, Lena Dager, Kelly L. Miners, Sian Llewellyn-Lacey, Kristin Ladell, Pragati S. Amratia, Kirsten Bentley, Simon Kollnberger, Jinghua Wu, Mily Akhirunnesa, Samantha A. Jones, Per Julin, Christer Lidman, Richard J. Stanton, Paul A. Goepfert, Michael J. Peluso, Steven G. Deeks, Helen E. Davies, Soo Aleman, Marcus Buggert, David A. Price
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Acetylcholine-secreting B cells constrain macrophage responses to influenza virus Nat. Immunol. (IF 27.7) Pub Date : 2025-04-29
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Interferon-β treatment restores myeloid function and reverses immunosuppression in sepsis Nat. Immunol. (IF 27.7) Pub Date : 2025-04-23
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Endothelium calls macrophages for destruction Nat. Immunol. (IF 27.7) Pub Date : 2025-04-22 Emmanuel L. Gautier
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B cells modulate lung antiviral inflammatory responses via the neurotransmitter acetylcholine Nat. Immunol. (IF 27.7) Pub Date : 2025-04-22 Antonio Cembellin-Prieto, Zheng Luo, Heather Kulaga, Nicole Baumgarth
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Macrophages and fibroblasts as regulators of the immune response in pancreatic cancer Nat. Immunol. (IF 27.7) Pub Date : 2025-04-22 Mojdeh Shakiba, David A. Tuveson
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IL-10 targets IRF transcription factors to suppress IFN and inflammatory response genes by epigenetic mechanisms Nat. Immunol. (IF 27.7) Pub Date : 2025-04-22 Bikash Mishra, Mahesh Bachu, Ruoxi Yuan, Claire Wingert, Vidyanath Chaudhary, Caroline Brauner, Richard Bell, Lionel B. Ivashkiv
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Endothelial dysfunction drives atherosclerotic plaque macrophage-dependent abdominal aortic aneurysm formation Nat. Immunol. (IF 27.7) Pub Date : 2025-04-22 Danya Thayaparan, Takuo Emoto, Aniqa B. Khan, Rickvinder Besla, Homaira Hamidzada, Mahmoud El-Maklizi, Tharini Sivasubramaniyam, Shabana Vohra, Ash Hagerman, Sara Nejat, Charlotte E. Needham-Robbins, Tao Wang, Moritz Lindquist, Steven R. Botts, Stephanie A. Schroer, Masayuki Taniguchi, Taishi Inoue, Katsuhiro Yamanaka, Haotian Cui, Edouard Al-Chami, Hangjun Zhang, Marwan G. Althagafi, Aja Michalski
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Neutrophil senescence drives sexual dimorphism in bladder cancer Nat. Immunol. (IF 27.7) Pub Date : 2025-04-18
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Systemic inflammation impairs myelopoiesis and interferon type I responses in humans Nat. Immunol. (IF 27.7) Pub Date : 2025-04-18 Farid Keramati, Guus P. Leijte, Niklas Bruse, Inge Grondman, Ehsan Habibi, Cristian Ruiz-Moreno, Wout Megchelenbrink, Annemieke M. Peters van Ton, Hidde Heesakkers, Manita E. Bremmers, Erinke van Grinsven, Kiki Tesselaar, Selma van Staveren, Walter J. van der Velden, Frank W. Preijers, Brigit te Pas, Raoul van de Loop, Jelle Gerretsen, Mihai G. Netea, Hendrik G. Stunnenberg, Peter Pickkers, Matthijs
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Microbiota-shaped neutrophil senescence regulates sexual dimorphism in bladder cancer Nat. Immunol. (IF 27.7) Pub Date : 2025-04-11 Qingchen Zhu, Guiheng Zhang, Ming Cao, Huan Huang, Dan He, Zhongsheng Zang, Jing Xing, Ming Zhan, Siyu Pei, Xiuyu Deng, Juan Li, Guangxun Meng, Jing Xu, Dongfang Dai, Guohong Hu, Mingyue Zheng, Chenli Liu, Jun Qin, Yichuan Xiao
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Treg cells augment self-tolerance during infection Nat. Immunol. (IF 27.7) Pub Date : 2025-04-10 Ryoji Kawakami, Shimon Sakaguchi
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‘Complement-ing’ tissue inflammation via granzyme K? Nat. Immunol. (IF 27.7) Pub Date : 2025-04-04 Dimitrios C. Mastellos, John D. Lambris
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Human immunology soars in Japan Nat. Immunol. (IF 27.7) Pub Date : 2025-04-04 Yuki Masuo, Dongyun Lu, Joey Matsuyama, Eui-Cheol Shin, Hideki Ueno
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Addendum: Langerhans cells renew in the skin throughout life under steady-state conditions Nat. Immunol. (IF 27.7) Pub Date : 2025-04-04 Miriam Merad, Markus G. Manz, Holger Karsunky, Amy Wagers, Wendy Peters, Israel Charo, Irving L. Weissman, Jason G. Cyster, Edgar G. Engleman
Addendum to: Nature Immunology https://doi.org/10.1038/ni852, published online 4 November 2002.
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IFNλ drives diarrhea Nat. Immunol. (IF 27.7) Pub Date : 2025-03-31 Paula Jauregui
Some viral infections cause diarrhea, but the contribution of the host response to the pathophysiology of diarrhea was unknown. In Cell Host and Microbe, Hou et al. use a model of inactivated rotavirus to show that diarrhea is driven by type III interferon (IFNλ). The authors infected neonatal mice with UV-inactivated rotavirus and found that it led to diarrhea. By infecting a panel of genetically
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Building immune barriers Nat. Immunol. (IF 27.7) Pub Date : 2025-03-31 Laurie A. Dempsey
Tissues such as the skin, lungs and gut are constantly exposed to diverse microbial communities and must maintain tight barriers to prevent infection of underlying tissues. In Nature, Vicanolo et al. identify a unique subset of tissue-resident neutrophils found in barrier tissues that are capable of synthesizing extracellular matrix (ECM) components, such as collagen and fibronectin, that contribute
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Mapping STING Nat. Immunol. (IF 27.7) Pub Date : 2025-03-31 Nicholas J. Bernard
Stimulator of interferon genes (STING) is known for its nucleic acid-sensing type 1 interferon (IFN) responses to inflammatory pathologies such as viruses and cancer, but STING also possesses IFN-independent activities that are less well understood. To address this deficit, researchers generated a STING-reporter mouse (StingIRES-EGFP) to map STING expression in various tissues and during immune cell
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Peroxisomes mediate tissue repair Nat. Immunol. (IF 27.7) Pub Date : 2025-03-31 Stephanie Houston
Peroxisomes are cellular organelles involved in lipid metabolism and maintaining redox balance, but whether they are involved in the antiviral immune response to SARS-CoV-2 infection is not known. In Science, Wei et al. find that peroxisomes in alveolar macrophages (AMs) regulate lung inflammation after viral injury and may contribute to the development of post-acute sequelae of COVID-19 (PASC). In
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Overcoming TGFβ and activin A suppression boosts NK cell antitumor function Nat. Immunol. (IF 27.7) Pub Date : 2025-03-27
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ImmGenMaps, an open-source cartography of the immune system Nat. Immunol. (IF 27.7) Pub Date : 2025-03-26 Miguel Reina-Campos, Samouil L. Farhi, Christophe Benoist
The Immunological Genome Project Consortium (ImmGen) is announcing the launch of ImmGenMaps (https://www.immgen.org/ImmGenMaps), a project designed to spatially profile every immune cell across the mouse anatomy. This community project builds upon the bulk and single-cell profiling efforts of ImmGen to characterize the genetic regulation of all cells of the mouse immune system. Using state-of-the-art
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Distinct type 1 immune networks underlie the severity of restrictive lung disease after COVID-19 Nat. Immunol. (IF 27.7) Pub Date : 2025-03-26 Glenda Canderan, Lyndsey M. Muehling, Alexandra Kadl, Shay Ladd, Catherine Bonham, Claire E. Cross, Sierra M. Lima, Xihui Yin, Jeffrey M. Sturek, Jeffrey M. Wilson, Behnam Keshavarz, Kyle B. Enfield, Chintan Ramani, Naomi Bryant, Deborah D. Murphy, In Su Cheon, Michael Solga, Patcharin Pramoonjago, Coleen A. McNamara, Jie Sun, Paul J. Utz, Sepideh Dolatshahi, Jonathan M. Irish, Judith A. Woodfolk
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An SSTR2–somatostatin chemotactic axis drives T cell progenitor homing to the intestines Nat. Immunol. (IF 27.7) Pub Date : 2025-03-26 Borja Ocón, Kevin F. Brulois, Husein Hadeiba, Mohammed Gaafarelkhalifa, Aiman Ayesha, Yuhan Bi, Menglan Xiang, Jacob Gulman, Maryam Kooshesh, Junliang Pan, Eugene C. Butcher
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Enhancing human NK cell antitumor function by knocking out SMAD4 to counteract TGFβ and activin A suppression Nat. Immunol. (IF 27.7) Pub Date : 2025-03-21 Anna Rea, Sara Santana-Hernández, Javier Villanueva, Marta Sanvicente-García, Mariona Cabo, Jesús Suarez-Olmos, Fabricio Quimis, Mengjuan Qin, Eduard Llorens, Sandra Blasco-Benito, Lamberto Torralba-Raga, Lorena Perez, Bishan Bhattarai, Elisenda Alari-Pahissa, Anna-Maria Georgoudaki, Francesc Balaguer, Manel Juan, Julián Pardo, Toni Celià-Terrassa, Ana Rovira, Nina Möker, Congcong Zhang, Marco Colonna
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Author Correction: Transcriptional function of E2A, Ebf1, Pax5, Ikaros and Aiolos analyzed by in vivo acute protein degradation in early B cell development Nat. Immunol. (IF 27.7) Pub Date : 2025-03-21 Anna S. Fedl, Hiromi Tagoh, Sarah Gruenbacher, Qiong Sun, Robyn L. Schenk, Kimon Froussios, Markus Jaritz, Meinrad Busslinger, Tanja A. Schwickert
Correction to: Nature Immunology https://doi.org/10.1038/s41590-024-01933-7, published online 23 August 2024.
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Recycling dead bacteria to fuel macrophage immunometabolism Nat. Immunol. (IF 27.7) Pub Date : 2025-03-19 Shane M. O’Carroll, Luke A. J. O’Neill
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Multiplex targeting of immune-modulating genes in cancer Nat. Immunol. (IF 27.7) Pub Date : 2025-03-19 Erica L. Braverman, Dario A. A. Vignali, Creg J. Workman
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The brain’s regulators Nat. Immunol. (IF 27.7) Pub Date : 2025-03-19 Gustavo Gastão Davanzo, Jonathan Kipnis
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Navigating the path forward for evidence-based management of long COVID Nat. Immunol. (IF 27.7) Pub Date : 2025-03-19 Joseph J. Breen, Robert W. Eisinger, Sarah W. Read, John Beigel, Tara N. Palmore, H. Clifford Lane, Joseph P. Menetski, Stacey J. Adam, Elizabeth Geerling, Emma Roy, Julie Gerberding, Jeanne M. Marrazzo
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The epigenetic landscape of fate decisions in T cells Nat. Immunol. (IF 27.7) Pub Date : 2025-03-19 Atishay Jay, Carlos M. Pondevida, Golnaz Vahedi
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Tuft cell IL-17RB restrains IL-25 bioavailability and reveals context-dependent ILC2 hypoproliferation Nat. Immunol. (IF 27.7) Pub Date : 2025-03-12 Xiaogang Feng, Tilde Andersson, Pascal Flüchter, Julia Gschwend, Ivan Berest, Julian L. Muff, Antonie Lechner, Aurelia Gondrand, Patrick Westermann, Nina Brander, Daniele Carchidi, Jeshua C. De Tenorio, Tianlang Pan, Ulrich Boehm, Christoph S. N. Klose, David Artis, Christoph B. Messner, Trese Leinders-Zufall, Frank Zufall, Christoph Schneider
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Stored mRNA enables rapid cytokine production in tissue-resident memory T cells Nat. Immunol. (IF 27.7) Pub Date : 2025-03-11
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Author Correction: The lactate receptor HCAR1 drives the recruitment of immunosuppressive PMN-MDSCs in colorectal cancer Nat. Immunol. (IF 27.7) Pub Date : 2025-03-10 Jiacheng He, Xiaolei Chai, Qiansen Zhang, Yang Wang, Yijie Wang, Xinyu Yang, Jingbo Wu, Bo Feng, Jing Sun, Weiwei Rui, Shuyin Ze, Yuanyuan Fu, Yumiao Zhao, Ying Zhang, Yao Zhang, Meizhen Liu, Chuang Liu, Meifu She, Xiangfei Hu, Xueyun Ma, Huaiyu Yang, Dawei Li, Senlin Zhao, Guichao Li, Zhen Zhang, Zhonghui Tian, Yanlin Ma, Lingyan Cao, Bo Yi, Dali Li, Ruth Nussinov, Charis Eng, Timothy A. Chan, Eytan
Correction to: Nature Immunology https://doi.org/10.1038/s41590-024-02068-5, published online 4 February 2025.
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The integrated stress response pathway controls cytokine production in tissue-resident memory CD4+ T cells Nat. Immunol. (IF 27.7) Pub Date : 2025-03-06 Nariaki Asada, Pauline Ginsberg, Hans-Joachim Paust, Ning Song, Jan-Hendrik Riedel, Jan-Eric Turner, Anett Peters, Anna Kaffke, Jonas Engesser, Huiying Wang, Yu Zhao, Robin Khatri, Philipp Gild, Roland Dahlem, Björn-Philipp Diercks, Sarada Das, Zoya Ignatova, Tobias B. Huber, Immo Prinz, Nicola Gagliani, Hans-Willi Mittrücker, Christian F. Krebs, Ulf Panzer
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Eva Klein (1925–2025) Nat. Immunol. (IF 27.7) Pub Date : 2025-03-07 Maria G. Masucci, Ingemar Ernberg
Before the discoveries of DNA structure and the genetic code, the function of nucleic acids, an abundant but mysterious cell component, was the subject of wide speculation. Studying the DNA content of Ehrlich carcinoma ascites cells — a considerable improvement from earlier studies on solid tumors — the Kleins found a correlation between the DNA content and growth properties of malignant cells. Subsequent
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A critical role of N4-acetylation of cytidine in mRNA by NAT10 in T cell expansion and antiviral immunity Nat. Immunol. (IF 27.7) Pub Date : 2025-03-05 Lu Sun, Xiaoyan Li, Feixiang Xu, Yuwen Chen, Xushuo Li, Zhicheng Yang, Ying Yang, Ke Wang, Tianyi Ren, Zihao Lin, Hua Wang, Xiangdong Wang, Yan Lu, Zhenju Song, Zhou-Li Cheng, Duojiao Wu
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Enteric cross-talk Nat. Immunol. (IF 27.7) Pub Date : 2025-03-03 Ioana Staicu
The gut is innervated by ganglia neurons, such as dorsal root ganglia (DRG) and celiac-superior mesenteric ganglia (CG-SMG) neurons, and by intrinsic enteric neurons (iENs), which have autonomous reflex activity. In Immunity, Wang et al. show that helminth infection triggers the accumulation of iENs that express c-FOS, a marker of neuronal activation. A cluster of small intestine iENs identified by
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Tissue directives Nat. Immunol. (IF 27.7) Pub Date : 2025-03-03 Laurie A. Dempsey
Hematopoietic stem cell transplantation (HSCT) offers potentially curative therapies for patients with in-borne hematopoietic disorders or those undergoing treatments for hematological malignancies. However, notable morbidity or mortality can occur in patients receiving HSCT, owing to graft-versus-host disease (GVHD). In Science Translational Medicine, Omdahl et al. use a systems immunology approach
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Anti-tumor CTLs need IL-27 Nat. Immunol. (IF 27.7) Pub Date : 2025-03-03 Paula Jauregui
Cytotoxic CD8+ T lymphocytes (CTLs) can be dysfunctional in tumors, but treatment with cytokines could help their anti-tumor activity. In Nature, Bréart et al. show that IL-27 is required for host-protective anti-tumor immunity, and that IL-27 receptor agonism enhances CTL responses and tumor control, without toxicity. By analyzing published genomic and transcriptomic data, the authors found that IL27
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Enhancing T cell therapy Nat. Immunol. (IF 27.7) Pub Date : 2025-03-03 Nicholas J. Bernard
Adoptive cell therapies require the in vitro culture of engineered cells, a process that is primarily designed to expand the population of cells using supraphysiological concentrations of metabolites such as glucose. Data now published in Cell Metabolism show that these culture systems result in T cells that are not optimal for killing tumors. The researchers compared in vitro and in vivo expansion
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Enteric GABAergic neuron-derived γ-aminobutyric acid initiates expression of Igfbp7 to sustain ILC3 homeostasis Nat. Immunol. (IF 27.7) Pub Date : 2025-03-03 Nian Liu, Jiacheng He, Yanmei Yang, Yunlong Wang, Lingwei Zhang, Ziqi Xiao, Zhen Xiong, Shangxun Zhong, Yuwei Xu, Yang Gu, Jianyi Wang, Yufei Lan, Ying Du, Pingping Zhu, Zhi Zhang, Xinjuan Fan, Benyu Liu, Zusen Fan
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Protective SARS-CoV-2-specific T cells take up residence Nat. Immunol. (IF 27.7) Pub Date : 2025-02-28 Paul Moss
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The rewired immune microenvironment in leukemia Nat. Immunol. (IF 27.7) Pub Date : 2025-02-28 Zoe Ciantra, Varvara Paraskevopoulou, Iannis Aifantis
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Autophagy repression in effector T lymphocytes redefines paradigms in T cell biology Nat. Immunol. (IF 27.7) Pub Date : 2025-02-27 Ruchi Saxena, You-Wen He