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HypoxyStat, a small-molecule form of hypoxia therapy that increases oxygen-hemoglobin affinity Cell (IF 45.5) Pub Date : 2025-02-17 Skyler Y. Blume, Ankur Garg, Yolanda Martí-Mateos, Ayush D. Midha, Brandon T.L. Chew, Baiwei Lin, Cecile Yu, Ryan Dick, Patrick S. Lee, Eva Situ, Richa Sarwaikar, Eric Green, Vyas Ramanan, Gijsbert Grotenbreg, Maarten Hoek, Christopher Sinz, Isha H. Jain
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Mammary intraepithelial lymphocytes promote lactogenesis and offspring fitness Cell (IF 45.5) Pub Date : 2025-02-14 Dan Corral, Eduard Ansaldo, Jérémie Delaleu, Andrea C. Pichler, Juraj Kabat, Cihan Oguz, Ana Teijeiro, Daniel Yong, Mahnoor Abid, Claudia A. Rivera, Verena M. Link, Katharine Yang, Liang Chi, Jia Nie, Olena Kamenyeva, Yiping Fan, Jerry Kok Yen Chan, Florent Ginhoux, Rémy Bosselut, Yasmine Belkaid
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Synonymous mutations promote tumorigenesis by disrupting m6A-dependent mRNA metabolism Cell (IF 45.5) Pub Date : 2025-02-13 Yiheng Lan, Zhen Xia, Qizhe Shao, Peng Lin, Jinhong Lu, Xiaoying Xiao, Mengyue Zheng, Di Chen, Yanmei Dou, Qi Xie
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Male-male interactions shape mate selection in Drosophila Cell (IF 45.5) Pub Date : 2025-02-13 Tom Hindmarsh Sten, Rufei Li, Florian Hollunder, Shade Eleazer, Vanessa Ruta
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Design of CoQ10 crops based on evolutionary history Cell (IF 45.5) Pub Date : 2025-02-13 Jing-Jing Xu, Yuan Lei, Xiao-Fan Zhang, Jian-Xu Li, Qiupeng Lin, Xiang-Dong Wu, Yu-Guo Jiang, Wenyi Zhang, Runtong Qian, Shu-Yi Xiong, Kuo Tan, Yu Jia, Qiang Zhou, Yan Jiang, Hang Fan, Yan-Bo Huang, Ling-Jian Wang, Ji-Yun Liu, Yu Kong, Qing Zhao, Xiao-Ya Chen
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Resistance to Striga parasitism through reduction of strigolactone exudation Cell (IF 45.5) Pub Date : 2025-02-12 Jiayang Shi, Cuo Mei, Fengyong Ge, Qingliang Hu, Xinwei Ban, Ran Xia, Peiyong Xin, Shujing Cheng, Gaohua Zhang, Jiawei Nie, Shiqi Zhang, Xiaowei Ma, Yi Wang, Jinfang Chu, Yuhang Chen, Bing Wang, Weihua Wu, Jiayang Li, Qi Xie, Feifei Yu
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ArfGAP2 promotes STING proton channel activity, cytokine transit, and autoinflammation Cell (IF 45.5) Pub Date : 2025-02-12 Subhajit Poddar, Samuel D. Chauvin, Christopher H. Archer, Wei Qian, Jean A. Castillo-Badillo, Xin Yin, W. Miguel Disbennett, Cathrine A. Miner, Joe A. Holley, Teresa V. Naismith, W. Alexander Stinson, Xiaochao Wei, Yue Ning, Jiayuan Fu, Trini A. Ochoa, Nehalee Surve, Shivam A. Zaver, Kimberly A. Wodzanowski, Katherine R. Balka, Rajan Venkatraman, Jonathan J. Miner
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Extracellular vesicles from the lung pro-thrombotic niche drive cancer-associated thrombosis and metastasis via integrin beta 2 Cell (IF 45.5) Pub Date : 2025-02-11 Serena Lucotti, Yusuke Ogitani, Candia M. Kenific, Jacob Geri, Young Hun Kim, Jinghua Gu, Uthra Balaji, Linda Bojmar, Lee Shaashua, Yi Song, Michele Cioffi, Pernille Lauritzen, Oveen M. Joseph, Tetsuhiko Asao, Paul M. Grandgenett, Michael A. Hollingsworth, Christopher Peralta, Alexandra E. Pagano, Henrik Molina, Harry B. Lengel, David Lyden
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Distinct mismatch-repair complex genes set neuronal CAG-repeat expansion rate to drive selective pathogenesis in HD mice Cell (IF 45.5) Pub Date : 2025-02-11 Nan Wang, Shasha Zhang, Peter Langfelder, Lalini Ramanathan, Fuying Gao, Mary Plascencia, Raymond Vaca, Xiaofeng Gu, Linna Deng, Leonardo E. Dionisio, Ha Vu, Emily Maciejewski, Jason Ernst, Brinda C. Prasad, Thomas F. Vogt, Steve Horvath, Jeffrey S. Aaronson, Jim Rosinski, X. William Yang
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Neutrophil-derived vesicles control complement activation to facilitate inflammation resolution Cell (IF 45.5) Pub Date : 2025-02-11 Alan Y. Hsu, Qingxiang Huang, Xiong Pi, Jianing Fu, Krishnan Raghunathan, Laxman Ghimire, Arumugam Balasubramanian, Xuemei Xie, Hongbo Yu, Fabien Loison, Viraga Haridas, Jiali Zha, Fei Liu, Shin-young Park, Kamal Bagale, Qian Ren, Yuping Fan, Yi Zheng, Jose A. Cancelas, Li Chai, Hongbo R. Luo
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Multiple independent acquisitions of ACE2 usage in MERS-related coronaviruses Cell (IF 45.5) Pub Date : 2025-02-07 Cheng-Bao Ma, Chen Liu, Young-Jun Park, Jingjing Tang, Jing Chen, Qing Xiong, Jimin Lee, Cameron Stewart, Daniel Asarnow, Jack Brown, M. Alejandra Tortorici, Xiao Yang, Ye-Hui Sun, Yuan-Mei Chen, Xiao Yu, Jun-Yu Si, Peng Liu, Fei Tong, Mei-Ling Huang, Jing Li, Huan Yan
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Molecular basis of convergent evolution of ACE2 receptor utilization among HKU5 coronaviruses Cell (IF 45.5) Pub Date : 2025-02-07 Young-Jun Park, Chen Liu, Jimin Lee, Jack T. Brown, Cheng-Bao Ma, Peng Liu, Risako Gen, Qing Xiong, Samantha K. Zepeda, Cameron Stewart, Amin Addetia, Caroline J. Craig, M. Alejandra Tortorici, Abeer N. Alshukairi, Tyler N. Starr, Huan Yan, David Veesler
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GUK1 activation is a metabolic liability in lung cancer Cell (IF 45.5) Pub Date : 2025-02-06 Jaime L. Schneider, Kiran Kurmi, Yutong Dai, Ishita Dhiman, Shakchhi Joshi, Brandon M. Gassaway, Christian W. Johnson, Nicole Jones, Zongyu Li, Christian P. Joschko, Toshio Fujino, Joao A. Paulo, Satoshi Yoda, Gerard Baquer, Daniela Ruiz, Sylwia A. Stopka, Liam Kelley, Andrew Do, Mari Mino-Kenudson, Lecia V. Sequist, Marcia C. Haigis
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The sounds of music: Tracing memories and pathways through research and resistance Cell (IF 45.5) Pub Date : 2025-02-06 Jheannelle Johnson
Jheannelle Johnson is a winner of the fifth annual Rising Black Scientists Awards for a scholar in the life and health sciences. We asked emerging Black scientists to tell us about their scientific vision and goals, experiences that sparked their interest in science, how they want to contribute to a more inclusive scientific community, and how these all fit together on their journey. This is her story
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Bridging worlds: A STEM journey from Nigeria to the US and back Cell (IF 45.5) Pub Date : 2025-02-06 Kenna Gloria Agbugba
Kenna Gloria Agbugba is a winner of the fifth annual Rising Black Scientists Awards for a scholar in the physical, data, earth, and environmental sciences. We asked emerging Black scientists to tell us about their scientific vision and goals, the experiences that sparked their interest in science, how they want to contribute to a more inclusive scientific community, and how these all fit together on
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Retooling science: Transforming tools into instruments of equity as a Black physician-scientist Cell (IF 45.5) Pub Date : 2025-02-06 Victor Ekuta
Victor Ekuta is a winner of the fifth annual Rising Black Scientists Awards for a scholar in the life and health sciences. We asked emerging Black scientists to tell us about their scientific vision and goals, the experiences that sparked their interest in science, how they want to contribute to a more inclusive scientific community, and how these all fit together on their journey. This is his story
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Inspiring the next generation of engineers and scientists to be champions of equitable change Cell (IF 45.5) Pub Date : 2025-02-06 Nyasha Milanzi
Nyasha Milanzi is a winner of the fifth annual Rising Black Scientists Awards for a scholar in the physical, data, earth, and environmental sciences. We asked emerging Black scientists to tell us about their scientific vision and goals, experiences that sparked their interest in science, how they want to contribute to a more inclusive scientific community, and how these all fit together on their journey
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Tumor “age” in early-onset colorectal cancer Cell (IF 45.5) Pub Date : 2025-02-06 Gianluca Mauri, Giorgio Patelli, Giovanni Crisafulli, Salvatore Siena, Alberto Bardelli
The incidence of early-onset colorectal cancer (EO-CRC) is surging, and by 2030, one-third of all CRCs will occur before the commonly recommended screening age of 50 years. The time required for EO-CRC to reach the metastatic stage is unknown, yet this knowledge is critical to tailor early-diagnosis screening strategies. Here, we discuss how defining a key biological feature of EO-CRC may be central
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Brainstem neuropeptidergic neurons link a neurohumoral axis to satiation Cell (IF 45.5) Pub Date : 2025-02-05 Srikanta Chowdhury, Nachiket G. Kamatkar, Wendy Xueyi Wang, Christa A. Akerele, Jiahao Huang, Junlin Wu, Amajindi Nwankpa, Charlotte M. Kane, Varun M. Bhave, Hao Huang, Xiao Wang, Alexander R. Nectow
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Engineered commensals for targeted nose-to-brain drug delivery Cell (IF 45.5) Pub Date : 2025-02-05 Haosheng Shen, Nikhil Aggarwal, Beiming Cui, Guo Wei Foo, Yuanzhi He, Santosh Kumar Srivastava, Shengjie Li, Marcus Ze Xian Seah, Kwok Soon Wun, Hua Ling, In Young Hwang, Chun Loong Ho, Yung Seng Lee, Matthew Wook Chang
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Rhodoquinone carries electrons in the mammalian electron transport chain Cell (IF 45.5) Pub Date : 2025-02-04 Jonathan Valeros, Madison Jerome, Tenzin Tseyang, Paula Vo, Thang Do, Diana Fajardo Palomino, Nils Grotehans, Manisha Kunala, Alexandra E. Jerrett, Nicolai R. Hathiramani, Michael Mireku, Rayna Y. Magesh, Batuhan Yenilmez, Paul C. Rosen, Jessica L. Mann, Jacob W. Myers, Tenzin Kunchok, Tanner L. Manning, Lily N. Boercker, Paige E. Carr, Jessica B. Spinelli
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Long-term imaging of individual ribosomes reveals ribosome cooperativity in mRNA translation Cell (IF 45.5) Pub Date : 2025-01-31 Maximilian F. Madern, Sora Yang, Olivier Witteveen, Hendrika A. Segeren, Marianne Bauer, Marvin E. Tanenbaum
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Resolving the three-dimensional interactome of human accelerated regions during human and chimpanzee neurodevelopment Cell (IF 45.5) Pub Date : 2025-01-30 Atreyo Pal, Mark A. Noble, Matheo Morales, Richik Pal, Marybeth Baumgartner, Je Won Yang, Kristina M. Yim, Severin Uebbing, James P. Noonan
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Early fusion intermediate of ACE2-using coronavirus spike acting as an antiviral target Cell (IF 45.5) Pub Date : 2025-01-30 Lixiao Xing, Zhimin Liu, Xinling Wang, Qianying Liu, Wei Xu, Qiyu Mao, Xiang Zhang, Aihua Hao, Shuai Xia, Zezhong Liu, Lujia Sun, Guangxu Zhang, Qian Wang, Zhenguo Chen, Shibo Jiang, Lei Sun, Lu Lu
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Identification, structure, and agonist design of an androgen membrane receptor Cell (IF 45.5) Pub Date : 2025-01-29 Zhao Yang, Yu-Qi Ping, Ming-Wei Wang, Chao Zhang, Shu-Hua Zhou, Yue-Tong Xi, Kong-Kai Zhu, Wei Ding, Qi-Yue Zhang, Zhi-Chen Song, Ru-Jia Zhao, Zi-Lu He, Meng-Xin Wang, Lei Qi, Christian Ullmann, Albert Ricken, Torsten Schöneberg, Zhen-Ji Gan, Xiao Yu, Peng Xiao, Jin-Peng Sun
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Mechanisms of memory-supporting neuronal dynamics in hippocampal area CA3 Cell (IF 45.5) Pub Date : 2025-01-25 Yiding Li, John J. Briguglio, Sandro Romani, Jeffrey C. Magee
(Cell 187, 6804–6819.e1–e21; November 27, 2024)
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Ligand interaction landscape of transcription factors and essential enzymes in E. coli Cell (IF 45.5) Pub Date : 2025-01-24 Hui Peng, Sergei Kotelnikov, Megan E. Egbert, Shany Ofaim, Grant C. Stevens, Sadhna Phanse, Tatiana Saccon, Mikhail Ignatov, Shubham Dutta, Zoe Istace, Mohamed Taha Moutaoufik, Hiroyuki Aoki, Neal Kewalramani, Jianxian Sun, Yufeng Gong, Dzmitry Padhorny, Gennady Poda, Andrey Alekseenko, Kathryn A. Porter, George Jones, Andrew Emili
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Designed mosaic nanoparticles enhance cross-reactive immune responses in mice Cell (IF 45.5) Pub Date : 2025-01-23 Eric Wang, Alexander A. Cohen, Luis F. Caldera, Jennifer R. Keeffe, Annie V. Rorick, Yusuf M. Adia, Priyanthi N.P. Gnanapragasam, Pamela J. Bjorkman, Arup K. Chakraborty
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A pair of LysM receptors mediates symbiosis and immunity discrimination in Marchantia Cell (IF 45.5) Pub Date : 2025-01-23 Xinhang Tan, Dapeng Wang, Xiaowei Zhang, Shuang Zheng, Xiaojie Jia, Hui Liu, Zilin Liu, Hao Yang, Huiling Dai, Xi Chen, Zhixin Qian, Ran Wang, Miaolian Ma, Peng Zhang, Nan Yu, Ertao Wang
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Cardiometabolic benefits of a non-industrialized-type diet are linked to gut microbiome modulation Cell (IF 45.5) Pub Date : 2025-01-23 Fuyong Li, Anissa M. Armet, Katri Korpela, Junhong Liu, Rodrigo Margain Quevedo, Francesco Asnicar, Benjamin Seethaler, Tianna B.S. Rusnak, Janis L. Cole, Zhihong Zhang, Shuang Zhao, Xiaohang Wang, Adele Gagnon, Edward C. Deehan, João F. Mota, Jeffrey A. Bakal, Russell Greiner, Dan Knights, Nicola Segata, Stephan C. Bischoff, Jens Walter
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Rational multienzyme architecture design with iMARS Cell (IF 45.5) Pub Date : 2025-01-23 Jiawei Wang, Xingyu Ouyang, Shiyu Meng, Bowen Zhao, Liangxu Liu, Chaofeng Li, Hengrun Li, Haotian Zheng, Yihan Liu, Ting Shi, Yi-Lei Zhao, Jun Ni
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Assembly and architecture of endogenous NMDA receptors in adult cerebral cortex and hippocampus Cell (IF 45.5) Pub Date : 2025-01-23 Ming Zhang, Juan Feng, Chun Xie, Nan Song, Chaozhi Jin, Jian Wang, Qun Zhao, Lihua Zhang, Boshuang Wang, Yidi Sun, Fei Guo, Yang Li, Shujia Zhu
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Structure-guided discovery of viral proteins that inhibit host immunity Cell (IF 45.5) Pub Date : 2025-01-23 Erez Yirmiya, Samuel J. Hobbs, Azita Leavitt, Ilya Osterman, Carmel Avraham, Dina Hochhauser, Barak Madhala, Marharyta Skovorodka, Joel M.J. Tan, Hunter C. Toyoda, Igor Chebotar, Maxim Itkin, Sergey Malitsky, Gil Amitai, Philip J. Kranzusch, Rotem Sorek
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Receptor binding, structure, and tissue tropism of cattle-infecting H5N1 avian influenza virus hemagglutinin Cell (IF 45.5) Pub Date : 2025-01-23 Hao Song, Tianjiao Hao, Pu Han, Haichen Wang, Xu Zhang, Xiaomei Li, Yuxuan Wang, Jiamin Chen, Ying Li, Xiyue Jin, Xuefeng Duan, Wei Zhang, Yuhai Bi, Ronghua Jin, Lei Sun, Ningli Wang, George F. Gao
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Cell after 50 Cell (IF 45.5) Pub Date : 2025-01-23 John W. Pham
Section snippets Main textIf you’re reading this editorial, it’s 2025, or later, perhaps. I’m typing these words as 2024 is winding down. It’s getting close to the end of December, and some of my colleagues at Cell Press have already shut down their computers for some much needed and deserved time off. I will close my computer soon, too. I’ll spend time with friends and family, spoil my dogs, and eat
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Rings of death: How NINJ1 executes plasma membrane rupture Cell (IF 45.5) Pub Date : 2025-01-23 Zhonghua Liu, Tsan Sam Xiao
Plasma membrane rupture during lytic cell death was previously believed to occur through passive osmosis that burst open the membrane. Recent publications, including one in this issue of Cell, suggest that plasma membrane rupture is an active process mediated by ninjurin-1 (NINJ1) oligomers that dissolve membranes and/or assemble large pores.
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Cell Line: 2014–2024 Cell (IF 45.5) Pub Date : 2025-01-23
Section snippets Main textAs we wrap up our year-long celebration of Cell’s 50th anniversary, we present “Cell Line: 2014–2024,” a Timeline highlighting a set of exceptional scientific works—both landmark papers and essential reviews—published in the journal. This fifth installment rounds out the five decades since Cell’s launch in 1974. Previous Cell Lines covered the decades since the journal’s inception:
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High-resolution spatially resolved proteomics of complex tissues based on microfluidics and transfer learning Cell (IF 45.5) Pub Date : 2025-01-23 Beiyu Hu, Ruiqiao He, Kun Pang, Guibin Wang, Ning Wang, Wenzhuo Zhu, Xin Sui, Huajing Teng, Tianxin Liu, Junjie Zhu, Zewen Jiang, Jinyang Zhang, Zhenqiang Zuo, Weihu Wang, Peifeng Ji, Fangqing Zhao
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Comparative proteomic landscapes elucidate human preimplantation development and failure Cell (IF 45.5) Pub Date : 2025-01-23 Wencheng Zhu, Juan Meng, Yan Li, Lei Gu, Wenjun Liu, Ziyi Li, Yi Shen, Xiaoyu Shen, Zihong Wang, Yonggen Wu, Guiquan Wang, Junfeng Zhang, Huiping Zhang, Haiyan Yang, Xi Dong, Hui Wang, Xuefeng Huang, Yidi Sun, Chen Li, Liangshan Mu, Zhen Liu
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Centromeric chromatin clearings demarcate the site of kinetochore formation Cell (IF 45.5) Pub Date : 2025-01-23 Kathryn Kixmoeller, Ekaterina V. Tarasovetc, Elie Mer, Yi-Wei Chang, Ben E. Black
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Integration of 168,000 samples reveals global patterns of the human gut microbiome Cell (IF 45.5) Pub Date : 2025-01-22 Richard J. Abdill, Samantha P. Graham, Vincent Rubinetti, Mansooreh Ahmadian, Parker Hicks, Ashwin Chetty, Daniel McDonald, Pamela Ferretti, Elizabeth Gibbons, Marco Rossi, Arjun Krishnan, Frank W. Albert, Casey S. Greene, Sean Davis, Ran Blekhman
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Massively parallel reporter assay investigates shared genetic variants of eight psychiatric disorders Cell (IF 45.5) Pub Date : 2025-01-22 Sool Lee, Jessica C. McAfee, Jiseok Lee, Alejandro Gomez, Austin T. Ledford, Declan Clarke, Hyunggyu Min, Mark B. Gerstein, Alan P. Boyle, Patrick F. Sullivan, Adriana S. Beltran, Hyejung Won
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KDM6B-dependent epigenetic programming of uterine fibroblasts in early pregnancy regulates parturition timing in mice Cell (IF 45.5) Pub Date : 2025-01-21 Tara I. McIntyre, Omar Valdez, Nathan P. Kochhar, Brittany Davidson, Bushra Samad, Longhui Qiu, Kenneth Hu, Alexis J. Combes, Adrian Erlebacher
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A natural variant of COOL1 gene enhances cold tolerance for high-latitude adaptation in maize Cell (IF 45.5) Pub Date : 2025-01-21 Rong Zeng, Yiting Shi, Li Guo, Diyi Fu, Minze Li, Xiaoyan Zhang, Zhuoyang Li, Junhong Zhuang, Xiaohong Yang, Jianru Zuo, Zhizhong Gong, Feng Tian, Shuhua Yang
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Systems-level immunomonitoring in children with solid tumors to enable precision medicine Cell (IF 45.5) Pub Date : 2025-01-20 Qi Chen, Binbin Zhao, Ziyang Tan, Gustav Hedberg, Jun Wang, Laura Gonzalez, Constantin Habimana Mugabo, Anette Johnsson, Erika Negrini, Laura Piñero Páez, Lucie Rodriguez, Anna James, Yang Chen, Jaromír Mikeš, Anna Karin Bernhardsson, Stefan Markus Reitzner, Ferdinand von Walden, Olivia O’Neill, Hugo Barcenilla, Chunlin Wang, Petter Brodin
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An atlas of transcription initiation reveals regulatory principles of gene and transposable element expression in early mammalian development Cell (IF 45.5) Pub Date : 2025-01-20 Marlies E. Oomen, Diego Rodriguez-Terrones, Mayuko Kurome, Valeri Zakhartchenko, Lorenza Mottes, Kilian Simmet, Camille Noll, Tsunetoshi Nakatani, Carlos Michel Mourra-Diaz, Irene Aksoy, Pierre Savatier, Jonathan Göke, Eckhard Wolf, Henrik Kaessmann, Maria-Elena Torres-Padilla
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Structural and functional analysis of the Nipah virus polymerase complex Cell (IF 45.5) Pub Date : 2025-01-20 Side Hu, Heesu Kim, Pan Yang, Zishuo Yu, Barbara Ludeke, Shawna Mobilia, Junhua Pan, Margaret Stratton, Yuemin Bian, Rachel Fearns, Jonathan Abraham
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Metagenome-informed metaproteomics of the human gut microbiome, host, and dietary exposome uncovers signatures of health and inflammatory bowel disease Cell (IF 45.5) Pub Date : 2025-01-20 Rafael Valdés-Mas, Avner Leshem, Danping Zheng, Yotam Cohen, Lara Kern, Niv Zmora, Yiming He, Corine Katina, Shimrit Eliyahu-Miller, Tal Yosef-Hevroni, Liron Richman, Barbara Raykhel, Shira Allswang, Reut Better, Merav Shmueli, Aurelia Saftien, Nyssa Cullin, Fernando Slamovitz, Dragos Ciocan, Kyanna S. Ouyang, Uria Mor, Mally Dori-Bachash, Shahar Molina, Yishai Levin, Koji Atarashi, Ghil Jona, Jens
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Fine-tuning of gene expression through the Mettl3-Mettl14-Dnmt1 axis controls ESC differentiation Cell (IF 45.5) Pub Date : 2025-01-17 Giuseppe Quarto, Andrea Li Greci, Martin Bizet, Audrey Penning, Irina Primac, Frédéric Murisier, Liliana Garcia-Martinez, Rodrigo L. Borges, Qingzeng Gao, Pradeep K.R. Cingaram, Emilie Calonne, Bouchra Hassabi, Céline Hubert, Adèle Herpoel, Pascale Putmans, Frédérique Mies, Jérôme Martin, Louis Van der Linden, Gaurav Dube, Pankaj Kumar, François Fuks
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Passage of the HIV capsid cracks the nuclear pore Cell (IF 45.5) Pub Date : 2025-01-17 Jan Philipp Kreysing, Maziar Heidari, Vojtech Zila, Sergio Cruz-León, Agnieszka Obarska-Kosinska, Vibor Laketa, Lara Rohleder, Sonja Welsch, Jürgen Köfinger, Beata Turoňová, Gerhard Hummer, Hans-Georg Kräusslich, Martin Beck
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Hyperacute rejection-engineered oncolytic virus for interventional clinical trial in refractory cancer patients Cell (IF 45.5) Pub Date : 2025-01-17 Liping Zhong, Lu Gan, Bing Wang, Tao Wu, Fei Yao, Wenlin Gong, Hongmei Peng, Zhiming Deng, Guoyou Xiao, Xiyu Liu, Jintong Na, Desong Xia, Xianjun Yu, Zhikun Zhang, Bangde Xiang, Yu Huo, Dan Yan, Zhixin Dong, Fang Fang, Yun Ma, Guanqiao Jin, Danke Su, Xiuli Liu, Qiang Li, Hai Liao, Chao Tang, Jian He, Zhiping Tang, Shilai Zhang, Bingqing Qiu, Zhi Yang, Lihui Yang, Ziqin Chen, Mengsi Zeng, Ronghua Feng
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A biophysical basis for the spreading behavior and limited diffusion of Xist Cell (IF 45.5) Pub Date : 2025-01-16 Mingrui Ding, Danni Wang, Hui Chen, Barry Kesner, Niklas-Benedikt Grimm, Uri Weissbein, Anna Lappala, Jiying Jiang, Carlos Rivera, Jizhong Lou, Pilong Li, Jeannie T. Lee
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SMC motor proteins extrude DNA asymmetrically and can switch directions Cell (IF 45.5) Pub Date : 2025-01-16 Roman Barth, Iain F. Davidson, Jaco van der Torre, Michael Taschner, Stephan Gruber, Jan-Michael Peters, Cees Dekker
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Spatiotemporal and genetic cell lineage tracing of endodermal organogenesis at single-cell resolution Cell (IF 45.5) Pub Date : 2025-01-16 Ke-Ran Li, Pei-Long Yu, Qi-Qi Zheng, Xin Wang, Xuan Fang, Lin-Chen Li, Cheng-Ran Xu
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Long somatic DNA-repeat expansion drives neurodegeneration in Huntington’s disease Cell (IF 45.5) Pub Date : 2025-01-16 Robert E. Handsaker, Seva Kashin, Nora M. Reed, Steven Tan, Won-Seok Lee, Tara M. McDonald, Kiely Morris, Nolan Kamitaki, Christopher D. Mullally, Neda R. Morakabati, Melissa Goldman, Gabriel Lind, Rhea Kohli, Elisabeth Lawton, Marina Hogan, Kiku Ichihara, Sabina Berretta, Steven A. McCarroll
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Cervicovaginal microbiome and natural history of Chlamydia trachomatis in adolescents and young women Cell (IF 45.5) Pub Date : 2025-01-15 Mykhaylo Usyk, Luke Carlson, Nicolas F. Schlecht, Christopher C. Sollecito, Evan Grassi, Fanua Wiek, Shankar Viswanathan, Howard D. Strickler, Anne Nucci-Sack, Angela Diaz, Robert D. Burk
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The gut-lung axis: Protozoa join the party Cell (IF 45.5) Pub Date : 2025-01-15 Nicola L. Harris, Benjamin J. Marsland
The gut microbiota is a powerful influencer of systemic immunity, with its impact on distal organs like the lungs garnering increasing attention. In this issue of Cell, Burrows et al. report that a gut protozoan plays a key role in shaping the immunological steady state of the lung.
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Trans-ancestry genome-wide study of depression identifies 697 associations implicating cell types and pharmacotherapies Cell (IF 45.5) Pub Date : 2025-01-14 Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Mark J. Adams, Fabian Streit, Xiangrui Meng, Swapnil Awasthi, Brett N. Adey, Karmel W. Choi, V. Kartik Chundru, Jonathan R.I. Coleman, Bart Ferwerda, Jerome C. Foo, Zachary F. Gerring, Olga Giannakopoulou, Priya Gupta, Alisha S.M. Hall, Arvid Harder, David M. Howard, Christopher Hübel, Alex S.F. Kwong, Daniel F. Levey,
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Ongoing chromothripsis underpins osteosarcoma genome complexity and clonal evolution Cell (IF 45.5) Pub Date : 2025-01-14 Jose Espejo Valle-Inclan, Solange De Noon, Katherine Trevers, Hillary Elrick, Ianthe A.E.M. van Belzen, Sonia Zumalave, Carolin M. Sauer, Mélanie Tanguy, Thomas Butters, Francesc Muyas, Alistair G. Rust, Fernanda Amary, Roberto Tirabosco, Adam Giess, Alona Sosinsky, Greg Elgar, Adrienne M. Flanagan, Isidro Cortés-Ciriano
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Selective excitation of bacteria enables growth suppression without antibiotics Cell (IF 45.5) Pub Date : 2025-01-09 Michael W. Chen, Yifan Dai
In a recently published article in Device, Saehyun Kim et al. report that selective excitation of bacteria can inhibit their proliferation in an antibiotic-free manner. We herein discuss the molecular and thermodynamic principles underlying this “selective excitability,” which provides a new aspect to understand bacterial physiology.