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m6A-modified cenRNA stabilizes CENPA to ensure centromere integrity in cancer cells Cell (IF 45.5) Pub Date : 2024-09-20 Zihong Kang, Ruimeng Li, Chang Liu, Xiaozhe Dong, Yuxuan Hu, Lei Xu, Xinyu Liu, Yunfan Xiang, Liming Gao, Wenzhe Si, Lei Wang, Qing Li, Liang Zhang, Huan Wang, Xuerui Yang, Jun Liu
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Profound cellular defects attribute to muscular pathogenesis in the rhesus monkey model of Duchenne muscular dystrophy Cell (IF 45.5) Pub Date : 2024-09-20 Shuaiwei Ren, Xin Fu, Wenting Guo, Raoxian Bai, Sheng Li, Ting Zhang, Jie Liu, Zhengbo Wang, Hui Zhao, Shengbao Suo, Weikang Zhang, Minzhi Jia, Weizhi Ji, Ping Hu, Yongchang Chen
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It took a long, long time: Ras and the race to cure cancer Cell (IF 45.5) Pub Date : 2024-09-19 Robert A. Weinberg
No Abstract
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A pontine-medullary loop crucial for REM sleep and its deficit in Parkinson’s disease Cell (IF 45.5) Pub Date : 2024-09-19 Mitsuaki Kashiwagi, Goichi Beck, Mika Kanuka, Yoshifumi Arai, Kaeko Tanaka, Chika Tatsuzawa, Yumiko Koga, Yuki C. Saito, Marina Takagi, Yo Oishi, Masanori Sakaguchi, Kousuke Baba, Masashi Ikuno, Hodaka Yamakado, Ryosuke Takahashi, Masashi Yanagisawa, Shigeo Murayama, Takeshi Sakurai, Kazuya Sakai, Yoshimi Nakagawa, Yu Hayashi
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Nothing about us without us: Sharing results with communities that provide genomic data Cell (IF 45.5) Pub Date : 2024-09-19 Sarah LeBaron von Baeyer, Rebecca M. Crocker, Rindra Rakotoarivony, Jean Freddy Ranaivoarisoa, Germain Jules Spiral, Tristan Pascart, Vehia Wheeler, Tehani Mairai, Noomi O. Gregersen, Stephane E. Castel, Laura M. Yerges-Armstrong, Keolu Fox, Kaja A. Wasik
Sharing genetic and other study results with the communities who participate in research falls under benefit-sharing and capacity-building initiatives that underpin a more equitable biomedical research relationship. Yet, which results to return and how remain fundamental challenges that persist in the absence of practical guidance and institutional policies. Here, we discuss how the return of results
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A transmitochondrial sodium gradient controls membrane potential in mammalian mitochondria Cell (IF 45.5) Pub Date : 2024-09-19
Eukaryotic cell function and survival rely on the use of a mitochondrial H+ electrochemical gradient (Δp), which is composed of an inner mitochondrial…
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A microbial future Cell (IF 45.5) Pub Date : 2024-09-19
Life as we know it began with microbes. Microbes sustain life on Earth, and every now and then, a microbe emerges that threatens the survival of an entire species. The dangers and benefits of microbial life are both enormous, as is their potential to help us live long, healthy, sustainable lives. Microbiology at Cell celebrates 50 years, and we’re proud to showcase the marvelous and yet mysterious
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Focus on fungi Cell (IF 45.5) Pub Date : 2024-09-19 Iliyan D. Iliev, Gordon D. Brown, Petra Bacher, Sarah L. Gaffen, Joseph Heitman, Bruce S. Klein, Michail S. Lionakis
Fungi play critical roles in the homeostasis of ecosystems globally and have emerged as significant causes of an expanding repertoire of devastating diseases in plants, animals, and humans. In this Commentary, we highlight the importance of fungal pathogens and argue for concerted research efforts to enhance understanding of fungal virulence, antifungal immunity, novel drug targets, antifungal resistance
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Virology—The next fifty years Cell (IF 45.5) Pub Date : 2024-09-19 Edward C. Holmes, Florian Krammer, Felicia D. Goodrum
Virology has made enormous advances in the last 50 years but has never faced such scrutiny as it does today. Herein, we outline some of the major advances made in virology during this period, particularly in light of the COVID-19 pandemic, and suggest some areas that may be of research importance in the next 50 years. We focus on several linked themes: cataloging the genomic and phenotypic diversity
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Africa in the era of pathogen genomics: Unlocking data barriers Cell (IF 45.5) Pub Date : 2024-09-19 Gerald Mboowa, Sofonias K. Tessema, Alan Christoffels, Nicaise Ndembi, Yenew Kebede Tebeje, Jean Kaseya
Rapid expansion of pathogen sequencing capacity in Africa has led to a paradigm shift from relying on others to locally generating genomic data and sharing it with the global community. However, several barriers remain to be unlocked for timely processing, analysis, dissemination, and effective use of pathogen sequence data for pandemic prevention, preparedness, and response.
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Modern microbiology: Embracing complexity through integration across scales Cell (IF 45.5) Pub Date : 2024-09-19 A. Murat Eren, Jillian F. Banfield
Microbes were the only form of life on Earth for most of its history, and they still account for the vast majority of life’s diversity. They convert rocks to soil, produce much of the oxygen we breathe, remediate our sewage, and sustain agriculture. Microbes are vital to planetary health as they maintain biogeochemical cycles that produce and consume major greenhouse gases and support large food webs
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Transforming vaccinology Cell (IF 45.5) Pub Date : 2024-09-19 Rino Rappuoli, Galit Alter, Bali Pulendran
The COVID-19 pandemic placed the field of vaccinology squarely at the center of global consciousness, emphasizing the vital role of vaccines as transformative public health tools. The impact of vaccines was recently acknowledged by the award of the 2023 Nobel Prize in Physiology or Medicine to Katalin Kariko and Drew Weissman for their seminal contributions to the development of mRNA vaccines. Here
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Scientists’ call to action: Microbes, planetary health, and the Sustainable Development Goals Cell (IF 45.5) Pub Date : 2024-09-19 Thomas W. Crowther, Rino Rappuoli, Cinzia Corinaldesi, Roberto Danovaro, Timothy J. Donohue, Jef Huisman, Lisa Y. Stein, James Kenneth Timmis, Kenneth Timmis, Matthew Z. Anderson, Lars R. Bakken, Matthew Baylis, Michael J. Behrenfeld, Philip W. Boyd, Ian Brettell, Ricardo Cavicchioli, Camille S. Delavaux, Christine M. Foreman, Janet K. Jansson, Britt Koskella, Laura G. van Galen
Microorganisms, including bacteria, archaea, viruses, fungi, and protists, are essential to life on Earth and the functioning of the biosphere. Here, we discuss the key roles of microorganisms in achieving the United Nations Sustainable Development Goals (SDGs), highlighting recent and emerging advances in microbial research and technology that can facilitate our transition toward a sustainable future
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Off the beaten track: Understudied microbes and their potential Cell (IF 45.5) Pub Date : 2024-09-19 Catharine Adams, A. Pedro Gonçalves, Sally Warring, Thijs J.G. Ettema, Laura S. Weyrich, Chelsey C. Spriggs
The world of microbes is diverse, but the majority of these fascinating organisms are not as famous (or perhaps infamous) as their pathogenic counterparts. Cell highlights six scientists whose work addresses some of the most fundamental questions in biology, even though their microbial models may seem a tad bit unconventional.
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Exploring RNA-guided DNA scissors in eukaryotes: Are Fanzors counterparts of CRISPR-Cas12s? Cell (IF 45.5) Pub Date : 2024-09-19 Satoshi N. Omura, Osamu Nureki
Fanzors are recently characterized RNA-guided DNA endonucleases found in eukaryotic organisms. In this issue of Cell, Xu, Saito et al. reveal the structural diversity of Fanzors and identify key features shared with TnpB and Cas12 proteins, providing a comprehensive perspective on their molecular function and evolution.
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A prokaryotic Argonaute protein recruits a helicase-nuclease to degrade invading plasmids Cell (IF 45.5) Pub Date : 2024-09-19 Dmitriy Ignatov, Vivekanandan Shanmuganathan, Emmanuelle Charpentier
DdmDE is a novel plasmid defense system that was discovered in the seventh pandemic Vibrio cholerae strain of the biotype O1 EI Tor. In this issue of Cell, Yang and coworkers reveal the mechanisms underlying the assembly and activation of the DdmDE defense system.
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A-tisket, a-tasket, what a beautiful nuclear basket Cell (IF 45.5) Pub Date : 2024-09-19 C. Patrick Lusk, Megan C. King
Nuclear pore complexes are massive protein gateways that control molecular exchange between the nucleus and cytoplasm. In this issue of Cell, Singh et al. provide the first high-resolution views of the elusive nuclear basket, which extends deep into the nucleus to coordinate functions from genome organization to mRNP export.
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Microbial colonization programs are structured by breastfeeding and guide healthy respiratory development Cell (IF 45.5) Pub Date : 2024-09-19
Breastfeeding and microbial colonization during infancy occur within a critical time window for development, and both are thought to influence the ris…
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Genetic tracing of market wildlife and viruses at the epicenter of the COVID-19 pandemic Cell (IF 45.5) Pub Date : 2024-09-19 Alexander Crits-Christoph, Joshua I. Levy, Jonathan E. Pekar, Stephen A. Goldstein, Reema Singh, Zach Hensel, Karthik Gangavarapu, Matthew B. Rogers, Niema Moshiri, Robert F. Garry, Edward C. Holmes, Marion P.G. Koopmans, Philippe Lemey, Thomas P. Peacock, Saskia Popescu, Andrew Rambaut, David L. Robertson, Marc A. Suchard, Joel O. Wertheim, Angela L. Rasmussen, Florence Débarre
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High-resolution functional mapping of RAD51C by saturation genome editing Cell (IF 45.5) Pub Date : 2024-09-18 Rebeca Olvera-León, Fang Zhang, Victoria Offord, Yajie Zhao, Hong Kee Tan, Prashant Gupta, Tuya Pal, Carla Daniela Robles-Espinoza, Fernanda G. Arriaga-González, Larissa Satiko Alcantara Sekimoto Matsuyama, Erwan Delage, Ed Dicks, Suzana Ezquina, Charlie F. Rowlands, Clare Turnbull, Paul Pharoah, John R.B. Perry, Maria Jasin, Andrew J. Waters, David J. Adams
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Fine-grained descending control of steering in walking Drosophila Cell (IF 45.5) Pub Date : 2024-09-17
Locomotion involves rhythmic limb movement patterns that originate in circuits outside the brain. Purposeful locomotion requires descending commands f…
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In vivo DNA replication dynamics unveil aging-dependent replication stress Cell (IF 45.5) Pub Date : 2024-09-17 Giacomo G. Rossetti, Noëlle Dommann, Angeliki Karamichali, Vasilis S. Dionellis, Ainhoa Asensio Aldave, Tural Yarahmadov, Eddie Rodriguez-Carballo, Adrian Keogh, Daniel Candinas, Deborah Stroka, Thanos D. Halazonetis
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Intracellular Ebola virus nucleocapsid assembly revealed by in situ cryo-electron tomography Cell (IF 45.5) Pub Date : 2024-09-17 Reika Watanabe, Dawid Zyla, Diptiben Parekh, Connor Hong, Ying Jones, Sharon L. Schendel, William Wan, Guillaume Castillon, Erica Ollmann Saphire
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Dynamic allostery drives autocrine and paracrine TGF-β signaling Cell (IF 45.5) Pub Date : 2024-09-16 Mingliang Jin, Robert I. Seed, Guoqing Cai, Tiffany Shing, Li Wang, Saburo Ito, Anthony Cormier, Stephanie A. Wankowicz, Jillian M. Jespersen, Jody L. Baron, Nicholas D. Carey, Melody G. Campbell, Zanlin Yu, Phu K. Tang, Pilar Cossio, Weihua Wen, Jianlong Lou, James Marks, Stephen L. Nishimura, Yifan Cheng
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Neoself-antigens are the primary target for autoreactive T cells in human lupus Cell (IF 45.5) Pub Date : 2024-09-13 Shunsuke Mori, Masako Kohyama, Yoshiaki Yasumizu, Asa Tada, Kaito Tanzawa, Tatsuya Shishido, Kazuki Kishida, Hui Jin, Masayuki Nishide, Shoji Kawada, Daisuke Motooka, Daisuke Okuzaki, Ryota Naito, Wataru Nakai, Teru Kanda, Takayuki Murata, Chikashi Terao, Koichiro Ohmura, Noriko Arase, Tomohiro Kurosaki, Hisashi Arase
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Long-term mesoscale imaging of 3D intercellular dynamics across a mammalian organ Cell (IF 45.5) Pub Date : 2024-09-13 Yuanlong Zhang, Mingrui Wang, Qiyu Zhu, Yuduo Guo, Bo Liu, Jiamin Li, Xiao Yao, Chui Kong, Yi Zhang, Yuchao Huang, Hai Qi, Jiamin Wu, Zengcai V. Guo, Qionghai Dai
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Intercellular nanotube-mediated mitochondrial transfer enhances T cell metabolic fitness and antitumor efficacy Cell (IF 45.5) Pub Date : 2024-09-13 Jeremy G. Baldwin, Christoph Heuser-Loy, Tanmoy Saha, Roland C. Schelker, Dragana Slavkovic-Lukic, Nicholas Strieder, Inmaculada Hernandez-Lopez, Nisha Rana, Markus Barden, Fabio Mastrogiovanni, Azucena Martín-Santos, Andrea Raimondi, Philip Brohawn, Brandon W. Higgs, Claudia Gebhard, Veena Kapoor, William G. Telford, Sanjivan Gautam, Maria Xydia, Philipp Beckhove, Luca Gattinoni
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Co-opting templated aggregation to degrade pathogenic tau assemblies and improve motor function Cell (IF 45.5) Pub Date : 2024-09-13 Lauren V.C. Miller, Guido Papa, Marina Vaysburd, Shi Cheng, Paul W. Sweeney, Annabel Smith, Catarina Franco, Taxiarchis Katsinelos, Melissa Huang, Sophie A.I. Sanford, Jonathan Benn, Jasmine Farnsworth, Katie Higginson, Holly Joyner, William A. McEwan, Leo C. James
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A developmental gradient reveals biosynthetic pathways to eukaryotic toxins in monocot geophytes Cell (IF 45.5) Pub Date : 2024-09-13 Niraj Mehta, Yifan Meng, Richard Zare, Rina Kamenetsky-Goldstein, Elizabeth Sattely
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Metformin decelerates aging clock in male monkeys Cell (IF 45.5) Pub Date : 2024-09-12 Yuanhan Yang, Xiaoyong Lu, Ning Liu, Shuai Ma, Hui Zhang, Zhiyi Zhang, Kuan Yang, Mengmeng Jiang, Zikai Zheng, Yicheng Qiao, Qinchao Hu, Ying Huang, Yiyuan Zhang, Muzhao Xiong, Lixiao Liu, Xiaoyu Jiang, Pradeep Reddy, Xueda Dong, Fanshu Xu, Qiaoran Wang, Qian Zhao, Jinghui Lei, Shuhui Sun, Ying Jing, Jingyi Li, Yusheng Cai, Yanling Fan, Kaowen Yan, Yaobin Jing, Amin Haghani, Mengen Xing, Xuan Zhang
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TEX264 drives selective autophagy of DNA lesions to promote DNA repair and cell survival Cell (IF 45.5) Pub Date : 2024-09-11 Pauline Lascaux, Gwendoline Hoslett, Sara Tribble, Camilla Trugenberger, Ivan Antičević, Cecile Otten, Ignacio Torrecilla, Stelios Koukouravas, Yichen Zhao, Hongbin Yang, Ftoon Aljarbou, Annamaria Ruggiano, Wei Song, Cristiano Peron, Giulio Deangeli, Enric Domingo, James Bancroft, Loïc Carrique, Errin Johnson, Iolanda Vendrell, Kristijan Ramadan
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Cross-disorder and disease-specific pathways in dementia revealed by single-cell genomics Cell (IF 45.5) Pub Date : 2024-09-11 Jessica E. Rexach, Yuyan Cheng, Lawrence Chen, Damon Polioudakis, Li-Chun Lin, Vivianne Mitri, Andrew Elkins, Xia Han, Mai Yamakawa, Anna Yin, Daniela Calini, Riki Kawaguchi, Jing Ou, Jerry Huang, Christopher Williams, John Robinson, Stephanie E. Gaus, Salvatore Spina, Edward B. Lee, Lea T. Grinberg, Daniel H. Geschwind
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Biomolecular condensates regulate cellular electrochemical equilibria Cell (IF 45.5) Pub Date : 2024-09-10 Yifan Dai, Zhengqing Zhou, Wen Yu, Yuefeng Ma, Kyeri Kim, Nelson Rivera, Javid Mohammed, Erica Lantelme, Heileen Hsu-Kim, Ashutosh Chilkoti, Lingchong You
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Safe and effective in vivo delivery of DNA and RNA using proteolipid vehicles Cell (IF 45.5) Pub Date : 2024-09-10 Douglas W. Brown, Ping Wee, Prakash Bhandari, Amirali Bukhari, Liliya Grin, Hector Vega, Maryam Hejazi, Deborah Sosnowski, Jailal Ablack, Eileen K. Clancy, Desmond Pink, Jitendra Kumar, Maria Paola Solis Ares, Suellen Lamb, Rodrigo Quevedo, Bijal Rawal, Fahed Elian, Natasha Rana, Luis Morales, Natasha Govindasamy, John D. Lewis
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Targeting Ras-, Rho-, and Rab-family GTPases via a conserved cryptic pocket Cell (IF 45.5) Pub Date : 2024-09-09 Johannes Morstein, Victoria Bowcut, Micah Fernando, Yue Yang, Lawrence Zhu, Meredith L. Jenkins, John T. Evans, Keelan Z. Guiley, D. Matthew Peacock, Sophie Krahnke, Zhi Lin, Katrine A. Taran, Benjamin J. Huang, Andrew G. Stephen, John E. Burke, Felice C. Lightstone, Kevan M. Shokat
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TGF-β and RAS jointly unmask primed enhancers to drive metastasis Cell (IF 45.5) Pub Date : 2024-09-06 Jun Ho Lee, Francisco J. Sánchez-Rivera, Lan He, Harihar Basnet, Fei Xavier Chen, Elena Spina, Liangji Li, Carles Torner, Jason E. Chan, Dig Vijay Kumar Yarlagadda, Jin Suk Park, Carleigh Sussman, Charles M. Rudin, Scott W. Lowe, Tuomas Tammela, Maria J. Macias, Richard P. Koche, Joan Massagué
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Divergent sensory pathways of sneezing and coughing Cell (IF 45.5) Pub Date : 2024-09-06 Haowu Jiang, Huan Cui, Mengyu Chen, Fengxian Li, Xiaolei Shen, Changxiong J. Guo, George E. Hoekel, Yuyan Zhu, Liang Han, Kangyun Wu, Michael J. Holtzman, Qin Liu
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Small-molecule GSDMD agonism in tumors stimulates antitumor immunity without toxicity Cell (IF 45.5) Pub Date : 2024-09-06 Pietro Fontana, Gang Du, Ying Zhang, Haiwei Zhang, Setu M. Vora, Jun Jacob Hu, Ming Shi, Ahmet B. Tufan, Liam B. Healy, Shiyu Xia, Dian-Jang Lee, Zhouyihan Li, Pilar Baldominos, Heng Ru, Hongbo R. Luo, Judith Agudo, Judy Lieberman, Hao Wu
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Sex-dependent effects in the aged melanoma tumor microenvironment influence invasion and resistance to targeted therapy Cell (IF 45.5) Pub Date : 2024-09-06 Yash Chhabra, Mitchell E. Fane, Sneha Pramod, Laura Hüser, Daniel J. Zabransky, Vania Wang, Agrani Dixit, Ruzhang Zhao, Edwin Kumah, Megan L. Brezka, Kevin Truskowski, Asmita Nandi, Gloria E. Marino-Bravante, Alexis E. Carey, Naina Gour, Devon A. Maranto, Murilo R. Rocha, Elizabeth I. Harper, Justin Ruiz, Evan J. Lipson, Ashani T. Weeraratna
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Humans are unreliable models of mouse disease Cell (IF 45.5) Pub Date : 2024-09-05 Brian S. Kim
In defying conventional views that dismissed itch as trivial, I persisted in studying basophils and ILC2s in human skin and atopic dermatitis. My research on JAK inhibitors for itch ultimately led to FDA-approved drugs. This is my story of disregarding categories and definitions—a story about an unconventional path in science that emphasizes innovation over conformity.
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Deep learning meets histones at the replication fork Cell (IF 45.5) Pub Date : 2024-09-05 Hiten D. Madhani
Epigenetic inheritance of heterochromatin requires transfer of parental H3-H4 tetramers to both daughter duplexes during replication. Three recent papers exploit yeast genetics coupled to inheritance assays and AlphaFold2-multimer predictions coupled to biochemistry to reveal that a replisome component (Mrc1/CLASPIN) is an H3-H4 tetramer chaperone important for parental histone transfer to daughters
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Off-the-shelf CAR-T cells could prove paradigm shifting for autoimmune diseases Cell (IF 45.5) Pub Date : 2024-09-05 Daniel J. Baker, Carl H. June
Early reports suggest that chimeric antigen receptor (CAR)-T therapy has remarkable potential for treating autoimmune disease. Current approaches rely on autologous CAR-T cells, creating a bottleneck to the broad deployment of this therapy. In this issue of Cell, Wang et al.1 report the first use of allogeneic CAR-T cells in three patients with systemic autoimmune disease.
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Harnessing immune cells to leverage PARP inhibitors Cell (IF 45.5) Pub Date : 2024-09-05 Tian-Li Wang, Ie-Ming Shih
Homologous-recombination deficiency in DNA repair characterizes a unique group of cancers that are vulnerable to PARP inhibitors and cytotoxic chemotherapy. In this issue of Cell, Luo et al., demonstrated that this genetic attribute in cancer cells may reprogram tumor immune microenvironment and show promise of targeting effector-Treg cells.
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Laws of thought in living cells Cell (IF 45.5) Pub Date : 2024-09-05 Carlise Sorenson, Katarzyna P. Adamala
Building biological computers is one of the most intensively pursued goals of modern synthetic biology. The new TriLoS tristate-based logic synthesis platform, published in this issue of Cell, offers a long-awaited solution to scale up the complexity of biocomputing, opening a path to move this field beyond proof-of-principle demonstrations.
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A systems view of the vascular endothelium in health and disease Cell (IF 45.5) Pub Date : 2024-09-05 Hellmut G. Augustin, Gou Young Koh
The dysfunction of blood-vessel-lining endothelial cells is a major cause of mortality. Although endothelial cells, being present in all organs as a single-cell layer, are often conceived as a rather inert cell population, the vascular endothelium as a whole should be considered a highly dynamic and interactive systemically disseminated organ. We present here a holistic view of the field of vascular
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Comparison of protection against mpox following mRNA or modified vaccinia Ankara vaccination in nonhuman primates Cell (IF 45.5) Pub Date : 2024-09-04 Eric M. Mucker, Alec W. Freyn, Sandra L. Bixler, Deniz Cizmeci, Caroline Atyeo, Patricia L. Earl, Harini Natarajan, Genesis Santos, Tiffany R. Frey, Rafael H. Levin, Anusha Meni, Guha A. Arunkumar, Daniel Stadlbauer, Patricia A. Jorquera, Hamilton Bennett, Joshua C. Johnson, Kath Hardcastle, Jeffrey L. Americo, Catherine A. Cotter, Jeff W. Koehler, Jay W. Hooper
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5-Formylcytosine is an activating epigenetic mark for RNA Pol III during zygotic reprogramming Cell (IF 45.5) Pub Date : 2024-08-29 Eleftheria Parasyraki, Medhavi Mallick, Victoria Hatch, Viviana Vastolo, Michael U. Musheev, Emil Karaulanov, Alexandr Gopanenko, Simon Moxon, Maria Méndez-Lago, Dandan Han, Lars Schomacher, Debasish Mukherjee, Christof Niehrs
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Unexplored microbial diversity from 2,500 food metagenomes and links with the human microbiome Cell (IF 45.5) Pub Date : 2024-08-29 Niccolò Carlino, Aitor Blanco-Míguez, Michal Punčochář, Claudia Mengoni, Federica Pinto, Alessia Tatti, Paolo Manghi, Federica Armanini, Michele Avagliano, Coral Barcenilla, Samuel Breselge, Raul Cabrera-Rubio, Inés Calvete-Torre, Mairéad Coakley, José F. Cobo-Díaz, Francesca De Filippis, Hrituraj Dey, John Leech, Eline S. Klaassens, Stephen Knobloch, Edoardo Pasolli
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Cryo-EM-based discovery of a pathogenic parvovirus causing epidemic mortality by black wasting disease in farmed beetles Cell (IF 45.5) Pub Date : 2024-08-28 Judit J. Penzes, Martin Holm, Samantha A. Yost, Jason T. Kaelber
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Molecular insights into human phosphatidylserine synthase 1 reveal its inhibition promotes LDL uptake Cell (IF 45.5) Pub Date : 2024-08-28 Tao Long, Dongyu Li, Goncalo Vale, Yaoyukun Jiang, Philip Schmiege, Zhongyue J. Yang, Jeffrey G. McDonald, Xiaochun Li
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Structural insights into the diversity and DNA cleavage mechanism of Fanzor Cell (IF 45.5) Pub Date : 2024-08-28 Peiyu Xu, Makoto Saito, Guilhem Faure, Samantha Maguire, Samuel Chau-Duy-Tam Vo, Max E. Wilkinson, Huihui Kuang, Bing Wang, William J. Rice, Rhiannon K. Macrae, Feng Zhang
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Mosaic sarbecovirus nanoparticles elicit cross-reactive responses in pre-vaccinated animals Cell (IF 45.5) Pub Date : 2024-08-27 Alexander A. Cohen, Jennifer R. Keeffe, Ariën Schiepers, Sandra E. Dross, Allison J. Greaney, Annie V. Rorick, Han Gao, Priyanthi N.P. Gnanapragasam, Chengcheng Fan, Anthony P. West, Arlene I. Ramsingh, Jesse H. Erasmus, Janice D. Pata, Hiromi Muramatsu, Norbert Pardi, Paulo J.C. Lin, Scott Baxter, Rita Cruz, Martina Quintanar-Audelo, Ellis Robb, Pamela J. Bjorkman
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Structural insights into the chloroplast protein import in land plants Cell (IF 45.5) Pub Date : 2024-08-27 Ke Liang, Zeyu Jin, Xiechao Zhan, Yuxin Li, Qikui Xu, Yanqiu Xie, Yi Yang, Shaojie Wang, Jianping Wu, Zhen Yan
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Animal and bacterial viruses share conserved mechanisms of immune evasion Cell (IF 45.5) Pub Date : 2024-08-27 Samuel J. Hobbs, Jason Nomburg, Jennifer A. Doudna, Philip J. Kranzusch
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Conservation and specialization of the Ycf2-FtsHi chloroplast protein import motor in green algae Cell (IF 45.5) Pub Date : 2024-08-27 Ke Liang, Xiechao Zhan, Yuxin Li, Yi Yang, Yanqiu Xie, Zeyu Jin, Xiaoyan Xu, Wenwen Zhang, Yang Lu, Sheng Zhang, Yilong Zou, Shan Feng, Jianping Wu, Zhen Yan
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Viral DNA polymerase structures reveal mechanisms of antiviral drug resistance Cell (IF 45.5) Pub Date : 2024-08-27 Sundaresh Shankar, Junhua Pan, Pan Yang, Yuemin Bian, Gábor Oroszlán, Zishuo Yu, Purba Mukherjee, David J. Filman, James M. Hogle, Mrinal Shekhar, Donald M. Coen, Jonathan Abraham
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A line attractor encoding a persistent internal state requires neuropeptide signaling Cell (IF 45.5) Pub Date : 2024-08-26 George Mountoufaris, Aditya Nair, Bin Yang, Dong-Wook Kim, Amit Vinograd, Samuel Kim, Scott W. Linderman, David J. Anderson
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Opposing GPCR signaling programs protein intake setpoint in Drosophila Cell (IF 45.5) Pub Date : 2024-08-27 Guangyan Wu, Tianji Ma, Clare E. Hancock, Santiago Gonzalez, Binod Aryal, Sharon Vaz, Gabrielle Chan, Madison Palarca-Wong, Nick Allen, Chan-I. Chung, Xiaokun Shu, Qili Liu
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The Fanconi anemia pathway induces chromothripsis and ecDNA-driven cancer drug resistance Cell (IF 45.5) Pub Date : 2024-08-23 Justin L. Engel, Xiao Zhang, Mingming Wu, Yan Wang, Jose Espejo Valle-Inclán, Qing Hu, Kidist S. Woldehawariat, Mathijs A. Sanders, Agata Smogorzewska, Jin Chen, Isidro Cortés-Ciriano, Roger S. Lo, Peter Ly
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Thyroid hormone remodels cortex to coordinate body-wide metabolism and exploration Cell (IF 45.5) Pub Date : 2024-08-22 Daniel R. Hochbaum, Lauren Hulshof, Amanda Urke, Wengang Wang, Alexandra C. Dubinsky, Hannah C. Farnsworth, Richard Hakim, Sherry Lin, Giona Kleinberg, Keiramarie Robertson, Canaria Park, Alyssa Solberg, Yechan Yang, Caroline Baynard, Naeem M. Nadaf, Celia C. Beron, Allison E. Girasole, Lynne Chantranupong, Marissa D. Cortopassi, Shannon Prouty, Bernardo L. Sabatini