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WIPI4 loss linked to ferroptosis Nat. Cell Biol. (IF 21.3) Pub Date : 2024-03-07 Yang Liu, Hongyuan Yang
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Loss of WIPI4 in neurodegeneration causes autophagy-independent ferroptosis Nat. Cell Biol. (IF 21.3) Pub Date : 2024-03-07 Ye Zhu, Motoki Fujimaki, Louisa Snape, Ana Lopez, Angeleen Fleming, David C. Rubinsztein
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Lipid droplets and cellular lipid flux Nat. Cell Biol. (IF 21.3) Pub Date : 2024-03-07 Alyssa J. Mathiowetz, James A. Olzmann
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Author Correction: Subclonal cooperation drives metastasis by modulating local and systemic immune microenvironments Nat. Cell Biol. (IF 21.3) Pub Date : 2024-03-05 Michalina Janiszewska, Doris P. Tabassum, Zafira Castaño, Simona Cristea, Kimiyo N. Yamamoto, Natalie L. Kingston, Katherine C. Murphy, Shaokun Shu, Nicholas W. Harper, Carlos Gil Del Alcazar, Maša Alečković, Muhammad B. Ekram, Ofir Cohen, Minsuk Kwak, Yuanbo Qin, Tyler Laszewski, Adrienne Luoma, Andriy Marusyk, Kai W. Wucherpfennig, Nikhil Wagle, Rong Fan, Franziska Michor, Sandra S. McAllister, Kornelia
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Distinct pathways drive anterior hypoblast specification in the implanting human embryo Nat. Cell Biol. (IF 21.3) Pub Date : 2024-03-05 Bailey A. T. Weatherbee, Antonia Weberling, Carlos W. Gantner, Lisa K. Iwamoto-Stohl, Zoe Barnikel, Amy Barrie, Alison Campbell, Paula Cunningham, Cath Drezet, Panagiota Efstathiou, Simon Fishel, Sandra Gutiérrez Vindel, Megan Lockwood, Rebecca Oakley, Catherine Pretty, Nabiha Chowdhury, Lucy Richardson, Anastasia Mania, Lauren Weavers, Leila Christie, Kay Elder, Phillip Snell, Magdalena Zernicka-Goetz
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ER remodelling by ER-phagy in neurogenesis Nat. Cell Biol. (IF 21.3) Pub Date : 2024-03-01 Maurizio Molinari
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Targeting stromal metabolism in pancreatic ductal adenocarcinoma Nat. Cell Biol. (IF 21.3) Pub Date : 2024-03-01 Miao Yin, Qun-Ying Lei
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Ironing out the details of ferroptosis Nat. Cell Biol. (IF 21.3) Pub Date : 2024-03-01 Donna D. Zhang
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Cancer-associated fibroblast-derived acetate promotes pancreatic cancer development by altering polyamine metabolism via the ACSS2–SP1–SAT1 axis Nat. Cell Biol. (IF 21.3) Pub Date : 2024-03-01 Divya Murthy, Kuldeep S. Attri, Surendra K. Shukla, Ravi Thakur, Nina V. Chaika, Chunbo He, Dezhen Wang, Kanupriya Jha, Aneesha Dasgupta, Ryan J. King, Scott E. Mulder, Joshua Souchek, Teklab Gebregiworgis, Vikant Rai, Rohit Patel, Tuo Hu, Sandeep Rana, Sai Sundeep Kollala, Camila Pacheco, Paul M. Grandgenett, Fang Yu, Vikas Kumar, Audrey J. Lazenby, Adrian R. Black, Susanna Ulhannan, Ajay Jain, Barish
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Combinatorial selective ER-phagy remodels the ER during neurogenesis Nat. Cell Biol. (IF 21.3) Pub Date : 2024-03-01 Melissa J. Hoyer, Cristina Capitanio, Ian R. Smith, Julia C. Paoli, Anna Bieber, Yizhi Jiang, Joao A. Paulo, Miguel A. Gonzalez-Lozano, Wolfgang Baumeister, Florian Wilfling, Brenda A. Schulman, J. Wade Harper
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A guideline on the molecular ecosystem regulating ferroptosis Nat. Cell Biol. (IF 21.3) Pub Date : 2024-02-29 Enyong Dai, Xin Chen, Andreas Linkermann, Xuejun Jiang, Rui Kang, Valerian E. Kagan, Hülya Bayir, Wan Seok Yang, Ana J. Garcia-Saez, Maria S. Ioannou, Tobias Janowitz, Qitao Ran, Wei Gu, Boyi Gan, Dmitri V. Krysko, Xiaofeng Zhu, Jiayi Wang, Stefan Krautwald, Shinya Toyokuni, Yangchun Xie, Florian R. Greten, Qing Yi, Joel Schick, Jiao Liu, Dmitry I. Gabrilovich, Jinbao Liu, Herbert J. Zeh, Donna D.
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Mesoscale condensates organize the cytoplasm Nat. Cell Biol. (IF 21.3) Pub Date : 2024-02-29 Leshani Ahangama Liyanage, Jonathon A. Ditlev
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Evidence for widespread cytoplasmic structuring into mesoscale condensates Nat. Cell Biol. (IF 21.3) Pub Date : 2024-02-29 Felix C. Keber, Thao Nguyen, Andrea Mariossi, Clifford P. Brangwynne, Martin Wühr
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CAMSAPs and nucleation-promoting factors control microtubule release from γ-TuRC Nat. Cell Biol. (IF 21.3) Pub Date : 2024-02-29 Dipti Rai, Yinlong Song, Shasha Hua, Kelly Stecker, Jooske L. Monster, Victor Yin, Riccardo Stucchi, Yixin Xu, Yaqian Zhang, Fangrui Chen, Eugene A. Katrukha, Maarten Altelaar, Albert J. R. Heck, Michal Wieczorek, Kai Jiang, Anna Akhmanova
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METTL3 restrains autoimmunity in β-cells Nat. Cell Biol. (IF 21.3) Pub Date : 2024-02-26 Balasubramanian Krishnamurthy, Helen E. Thomas
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Redox regulation of m6A methyltransferase METTL3 in β-cells controls the innate immune response in type 1 diabetes Nat. Cell Biol. (IF 21.3) Pub Date : 2024-02-26 Dario F. De Jesus, Zijie Zhang, Natalie K. Brown, Xiaolu Li, Ling Xiao, Jiang Hu, Matthew J. Gaffrey, Garrett Fogarty, Sevim Kahraman, Jiangbo Wei, Giorgio Basile, Tariq M. Rana, Clayton Mathews, Alvin C. Powers, Audrey V. Parent, Mark A. Atkinson, Sirano Dhe-Paganon, Decio L. Eizirik, Wei-Jun Qian, Chuan He, Rohit N. Kulkarni
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Contractility drives the spatio-temporal coordination of morphogenesis and cell fate in hair follicles Nat. Cell Biol. (IF 21.3) Pub Date : 2024-02-23
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Lessons from infrastructure and research advocacy in India Nat. Cell Biol. (IF 21.3) Pub Date : 2024-02-23 Arun K. Shukla
Scientists must actively advocate for infrastructure development and funding of emerging research directions through collective efforts. In India, this has been crucial to help reverse the brain drain and enable equitable contributions to research and development at the global level.
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Metabolic regulation of chemoresistance and immuno-surveillance in AML by SHP-1 Nat. Cell Biol. (IF 21.3) Pub Date : 2024-02-23
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Lysosomal channels sensing forces Nat. Cell Biol. (IF 21.3) Pub Date : 2024-02-22 Erika Riederer, Dejian Ren
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Drosophila TMEM63 and mouse TMEM63A are lysosomal mechanosensory ion channels Nat. Cell Biol. (IF 21.3) Pub Date : 2024-02-22 Kai Li, Yanmeng Guo, Yayu Wang, Ruijun Zhu, Wei Chen, Tong Cheng, Xiaofan Zhang, Yinjun Jia, Ting Liu, Wei Zhang, Lily Yeh Jan, Yuh Nung Jan
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Mapping T cell landscapes in B cell lymphomas Nat. Cell Biol. (IF 21.3) Pub Date : 2024-02-20 Ralf Küppers
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Multimodal and spatially resolved profiling identifies distinct patterns of T cell infiltration in nodal B cell lymphoma entities Nat. Cell Biol. (IF 21.3) Pub Date : 2024-02-20 Tobias Roider, Marc A. Baertsch, Donnacha Fitzgerald, Harald Vöhringer, Berit J. Brinkmann, Felix Czernilofsky, Mareike Knoll, Laura Llaó-Cid, Anna Mathioudaki, Bianca Faßbender, Maxime Herbon, Tobias Lautwein, Peter-Martin Bruch, Nora Liebers, Christian M. Schürch, Verena Passerini, Marc Seifert, Alexander Brobeil, Gunhild Mechtersheimer, Carsten Müller-Tidow, Oliver Weigert, Martina Seiffert, Garry
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Author Correction: Stiff matrix induces exosome secretion to promote tumour growth Nat. Cell Biol. (IF 21.3) Pub Date : 2024-02-12 Bin Wu, Di-Ao Liu, Lei Guan, Phyoe Kyawe Myint, LiKang Chin, Hien Dang, Ye Xu, Jinqi Ren, Ting Li, Ziyan Yu, Sophie Jabban, Gordon B. Mills, Jonathan Nukpezah, Youhai H. Chen, Emma E. Furth, Phyllis A. Gimotty, Rebecca G. Wells, Valerie M. Weaver, Ravi Radhakrishnan, Xin Wei Wang, Wei Guo
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Biomolecular condensation orchestrates clathrin-mediated endocytosis in plants Nat. Cell Biol. (IF 21.3) Pub Date : 2024-02-12 Jonathan Michael Dragwidge, Yanning Wang, Lysiane Brocard, Andreas De Meyer, Roman Hudeček, Dominique Eeckhout, Peter Grones, Matthieu Buridan, Clément Chambaud, Přemysl Pejchar, Martin Potocký, Joanna Winkler, Michaël Vandorpe, Nelson Serre, Matyáš Fendrych, Amelie Bernard, Geert De Jaeger, Roman Pleskot, Xiaofeng Fang, Daniël Van Damme
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mtDNA caught in the act again Nat. Cell Biol. (IF 21.3) Pub Date : 2024-02-08 Kate McArthur, Benjamin T. Kile
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Mitochondrial DNA replication stress triggers a pro-inflammatory endosomal pathway of nucleoid disposal Nat. Cell Biol. (IF 21.3) Pub Date : 2024-02-08 Laura E. Newman, Sammy Weiser Novak, Gladys R. Rojas, Nimesha Tadepalle, Cara R. Schiavon, Danielle A. Grotjahn, Christina G. Towers, Marie-Ève Tremblay, Matthew P. Donnelly, Sagnika Ghosh, Michaela Medina, Sienna Rocha, Ricardo Rodriguez-Enriquez, Joshua A. Chevez, Ian Lemersal, Uri Manor, Gerald S. Shadel
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Author Correction: Denervation-activated STAT3–IL-6 signalling in fibro-adipogenic progenitors promotes myofibres atrophy and fibrosis Nat. Cell Biol. (IF 21.3) Pub Date : 2024-02-07 Luca Madaro, Magda Passafaro, David Sala, Usue Etxaniz, Francesca Lugarini, Daisy Proietti, Maria Vittoria Alfonsi, Chiara Nicoletti, Sole Gatto, Marco De Bardi, Ricardo Rojas-García, Lorenzo Giordani, Sara Marinelli, Vittoria Pagliarini, Claudio Sette, Alessandra Sacco, Pier Lorenzo Puri
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Conference accessibility should be a universal concern Nat. Cell Biol. (IF 21.3) Pub Date : 2024-02-07 Urszula Lucja McClurg
In this piece, I share a personal encounter that underscores the glaring gaps in conference accessibility and challenges faced by disabled academics. I reveal historical biases and resistance to change and propose ways to transform conferences into more inclusive spaces, ensuring that all scientists can fully participate in the scientific discourse.
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ECSIT facilitates memory CD8+ T cell development by mediating fumarate synthesis during viral infection and tumorigenesis Nat. Cell Biol. (IF 21.3) Pub Date : 2024-02-07 Yongbing Yang, Yanan Wang, Zhongcheng Wang, Huanyu Yan, Yi Gong, Yingchao Hu, Yuying Jiang, Shuang Wen, Feifei Xu, Bingwei Wang, Fiachra Humphries, Yun Chen, Xi Wang, Shuo Yang
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Epithelial zonation along the mouse and human small intestine defines five discrete metabolic domains Nat. Cell Biol. (IF 21.3) Pub Date : 2024-02-06 Rachel K. Zwick, Petr Kasparek, Brisa Palikuqi, Sara Viragova, Laura Weichselbaum, Christopher S. McGinnis, Kara L. McKinley, Asoka Rathnayake, Dedeepya Vaka, Vinh Nguyen, Coralie Trentesaux, Efren Reyes, Alexander R. Gupta, Zev J. Gartner, Richard M. Locksley, James M. Gardner, Shalev Itzkovitz, Dario Boffelli, Ophir D. Klein
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SHP-1 inhibition targets leukaemia stem cells to restore immunosurveillance and enhance chemosensitivity by metabolic reprogramming Nat. Cell Biol. (IF 21.3) Pub Date : 2024-02-06 Xi Xu, Yanhui Yu, Wenwen Zhang, Weiwei Ma, Chong He, Guo Qiu, Xinyi Wang, Qiong Liu, Minyi Zhao, Jiayi Xie, Fang Tao, John M. Perry, Qifa Liu, Shuan Rao, Xunlei Kang, Meng Zhao, Linjia Jiang
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Compositional plasticity of the Atg1 complex Nat. Cell Biol. (IF 21.3) Pub Date : 2024-02-05 Xiaoli Ma, Hong Zhang
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A metabolite sensor subunit of the Atg1/ULK complex regulates selective autophagy Nat. Cell Biol. (IF 21.3) Pub Date : 2024-02-05 A. S. Gross, R. Ghillebert, M. Schuetter, E. Reinartz, A. Rowland, B. C. Bishop, M. Stumpe, J. Dengjel, M. Graef
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Orphan nuclear receptors joining the reprogramming club Nat. Cell Biol. (IF 21.3) Pub Date : 2024-02-02
Huck-Hui Ng is a senior group leader at the Genome Institute of Singapore of A*STAR. In this article, Ng revisits the 2009 Nature Cell Biology study in which he and his team described the role of Esrrb in somatic cell reprogramming.
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Lipid remodelling in mammalian development Nat. Cell Biol. (IF 21.3) Pub Date : 2024-02-01 Megumi Ibayashi, Satoshi Tsukamoto
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Mechanical forces across compartments coordinate cell shape and fate transitions to generate tissue architecture Nat. Cell Biol. (IF 21.3) Pub Date : 2024-02-01 Clémentine Villeneuve, Ali Hashmi, Irene Ylivinkka, Elizabeth Lawson-Keister, Yekaterina A. Miroshnikova, Carlos Pérez-González, Satu-Marja Myllymäki, Fabien Bertillot, Bhagwan Yadav, Tao Zhang, Danijela Matic Vignjevic, Marja L. Mikkola, M. Lisa Manning, Sara A. Wickström
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Finding the point of no return for cellular senescence Nat. Cell Biol. (IF 21.3) Pub Date : 2024-02-02
Eiji Hara is a professor at the Research Institute for Microbial Diseases, Osaka University, Japan. Eiji recalls the discovery of the basis for the irreversibility of cellular senescence, published in Nature Cell Biology in 2006.
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A serendipitous discovery of a family of membrane remodelling proteins Nat. Cell Biol. (IF 21.3) Pub Date : 2024-02-02
Pietro De Camilli is a professor of neuroscience and of cell biology at Yale University, CT, as well as an investigator in the Howard Hughes Medical Institute. Pietro discusses how his group’s 1999 Nature Cell Biology study linking amphiphysin with dynamin in clathrin-mediated endocytosis came to be.
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Low-input lipidomics reveals lipid metabolism remodelling during early mammalian embryo development Nat. Cell Biol. (IF 21.3) Pub Date : 2024-02-01 Ling Zhang, Jing Zhao, Sin Man Lam, Lang Chen, Yingzhuo Gao, Wenjie Wang, Yuyan Xu, Tianyu Tan, Hua Yu, Min Zhang, Xufeng Liao, Mengchen Wu, Tianyun Zhang, Jie Huang, Bowen Li, Quan D. Zhou, Ning Shen, Hyeon Jeong Lee, Cunqi Ye, Da Li, Guanghou Shui, Jin Zhang
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p300 nucleocytoplasmic shuttling underlies mTORC1 hyperactivation in Hutchinson–Gilford progeria syndrome Nat. Cell Biol. (IF 21.3) Pub Date : 2024-01-24 Sung Min Son, So Jung Park, Sophia Y. Breusegem, Delphine Larrieu, David C. Rubinsztein
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Changing course at the dawn of a genomics revolution Nat. Cell Biol. (IF 21.3) Pub Date : 2024-01-23
Sarah Teichmann, head of cellular genetics at the Wellcome Sanger Institute, reflects on the dawn of the single-cell genomics era and a pivotal decision that changed the course of her career.
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The joy of scientific discoveries and interactions Nat. Cell Biol. (IF 21.3) Pub Date : 2024-01-23
Danfeng Cai, an assistant professor in the Department of Biochemistry and Molecular Biology at the Johns Hopkins Bloomberg School of Public Health, discusses her career path, including her work on the biomolecular condensation of YAP, and her excitement in her ongoing work on transcriptional condensates.
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It started with a western Nat. Cell Biol. (IF 21.3) Pub Date : 2024-01-23
Maria Antonietta (Antonella) De Matteis is a professor of biology at the University of Naples Federico II and leads the cell biology programme at the Telethon Institute of Genetics and Medicine in Pozzuoli, Italy. Antonella recalls the beginning of her research program on phosphatidylinositol 4-phosphate (PI4P) at the Golgi, published in our pages in 1999 and 2004.
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C-to-G editing generates double-strand breaks causing deletion, transversion and translocation Nat. Cell Biol. (IF 21.3) Pub Date : 2024-01-23 Min Emma Huang, Yining Qin, Yafang Shang, Qian Hao, Chuanzong Zhan, Chaoyang Lian, Simin Luo, Liu Daisy Liu, Senxin Zhang, Yu Zhang, Yang Wo, Niu Li, Shuheng Wu, Tuantuan Gui, Binbin Wang, Yifeng Luo, Yanni Cai, Xiaojing Liu, Ziye Xu, Pengfei Dai, Simiao Li, Liang Zhang, Junchao Dong, Jian Wang, Xiaoqi Zheng, Yingjie Xu, Yihua Sun, Wei Wu, Leng-Siew Yeap, Fei-Long Meng
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Innate immune sensing of lysosomal dysfunction drives multiple lysosomal storage disorders Nat. Cell Biol. (IF 21.3) Pub Date : 2024-01-22 Ailian Wang, Chen Chen, Chen Mei, Shengduo Liu, Cong Xiang, Wen Fang, Fei Zhang, Yifan Xu, Shasha Chen, Qi Zhang, Xueli Bai, Aifu Lin, Dante Neculai, Bing Xia, Cunqi Ye, Jian Zou, Tingbo Liang, Xin-Hua Feng, Xinran Li, Chengyong Shen, Pinglong Xu
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How cell biology can save the planet Nat. Cell Biol. (IF 21.3) Pub Date : 2024-01-16 Karla M. Neugebauer
Climate change affects us all, and tackling it requires a concerted effort, but it isn’t always evident how cell biologists’ work can impact climate change. Here, I share my experience addressing climate change as a molecular cell biologist and educator.
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The rules of the totipotency treasure hunt Nat. Cell Biol. (IF 21.3) Pub Date : 2024-01-16 Graziano Martello
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Single-cell multi-omics profiling of human preimplantation embryos identifies cytoskeletal defects during embryonic arrest Nat. Cell Biol. (IF 21.3) Pub Date : 2024-01-18 Teng Wang, Junhua Peng, Jiaqi Fan, Ni Tang, Rui Hua, Xueliang Zhou, Zhihao Wang, Longfei Wang, Yanling Bai, Xiaowan Quan, Zimeng Wang, Li Zhang, Chen Luo, Weiqing Zhang, Xiangjin Kang, Jianqiao Liu, Lei Li, Lin Li
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Celebrating 25 years of cell biology Nat. Cell Biol. (IF 21.3) Pub Date : 2024-01-16
We celebrate the 25th anniversary of Nature Cell Biology with a series of commissioned content and an online collection of research articles across the journal’s broad scope. We look back at biological discoveries and discuss the roles of cell biologists in sustainability, our ongoing commitments to diversity, equity and inclusion, and goals for mentoring the next generation of cell scientists.
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Gender equity: toward redefining values Nat. Cell Biol. (IF 21.3) Pub Date : 2024-01-16 Chrystal A. Starbird, Zara Y. Weinberg, Mary Munson
Women and gender minorities make defining contributions to science. Despite increased representation of women across the scientific career ladder, institutions routinely fail to support their career advancement or value their input. For an equitable and intersectional future faculty, definitions of excellence must evolve to better value women’s contributions.
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Building a two-way street between cell biology and machine learning Nat. Cell Biol. (IF 21.3) Pub Date : 2024-01-16 Caroline Uhler
With biomedical sciences quickly outgrowing many other application areas in terms of data generation, there is a unique opportunity for life sciences to become one of the greatest beneficiaries of research in machine learning and AI, and also inspire foundational developments in it.
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Bringing computation to biology by bridging the last mile Nat. Cell Biol. (IF 21.3) Pub Date : 2024-01-16 Anne E. Carpenter, Shantanu Singh
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Talking with force at cell–cell adhesions Nat. Cell Biol. (IF 21.3) Pub Date : 2024-01-16 Zoya Mann, Alpha S. Yap
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Extracellular vesicles, genetic programmers Nat. Cell Biol. (IF 21.3) Pub Date : 2024-01-16 Graça Raposo, Philip D. Stahl
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A milestone in epithelial–mesenchymal transition Nat. Cell Biol. (IF 21.3) Pub Date : 2024-01-16 Yutong Sun, Li Ma
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Defining the chromatin signature of pluripotency Nat. Cell Biol. (IF 21.3) Pub Date : 2024-01-16 Nathalie Beaujean
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Implementing sustainable science in the lab Nat. Cell Biol. (IF 21.3) Pub Date : 2024-01-16 Kathryn J. Wattam, Matthew A. M. Todd, Anja Groth
As cell biologists, we aim to better our communities, but basic research is costly: instruments require energy, experiments consume copious single-use materials. Though governments, international bodies and universities must work to reduce this carbon footprint, we find sustainable research can also be shaped by individual actions in the lab.