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Loss of lenalidomide-induced megakaryocytic differentiation leads to therapy resistance in del(5q) myelodysplastic syndrome Nat. Cell Biol. (IF 17.728) Pub Date : 2020-04-06 Sergio Martinez-Høyer; Yu Deng; Jeremy Parker; Jihong Jiang; Angela Mo; T. Roderick Docking; Nadia Gharaee; Jenny Li; Patricia Umlandt; Megan Fuller; Martin Jädersten; Austin Kulasekararaj; Luca Malcovati; Alan F. List; Eva Hellström-Lindberg; Uwe Platzbecker; Aly Karsan
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LSM2-8 and XRN-2 contribute to the silencing of H3K27me3-marked genes through targeted RNA decay Nat. Cell Biol. (IF 17.728) Pub Date : 2020-04-06 Anna Mattout; Dimos Gaidatzis; Jan Padeken; Christoph D. Schmid; Florian Aeschimann; Véronique Kalck; Susan M. Gasser
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Cystine transporter regulation of pentose phosphate pathway dependency and disulfide stress exposes a targetable metabolic vulnerability in cancer Nat. Cell Biol. (IF 17.728) Pub Date : 2020-03-30 Xiaoguang Liu; Kellen Olszewski; Yilei Zhang; Esther W. Lim; Jiejun Shi; Xiaoshan Zhang; Jie Zhang; Hyemin Lee; Pranavi Koppula; Guang Lei; Li Zhuang; M. James You; Bingliang Fang; Wei Li; Christian M. Metallo; Masha V. Poyurovsky; Boyi Gan
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Chromatin replication and epigenetic cell memory Nat. Cell Biol. (IF 17.728) Pub Date : 2020-03-30 Kathleen R. Stewart-Morgan; Nataliya Petryk; Anja Groth
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KDM4A regulates the maternal-to-zygotic transition by protecting broad H3K4me3 domains from H3K9me3 invasion in oocytes Nat. Cell Biol. (IF 17.728) Pub Date : 2020-03-30 Aditya Sankar; Mads Lerdrup; Adeel Manaf; Jens Vilstrup Johansen; Javier Martin Gonzalez; Rehannah Borup; Robert Blanshard; Arne Klungland; Klaus Hansen; Claus Yding Andersen; John Arne Dahl; Kristian Helin; Eva R. Hoffmann
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Netrin-1 promotes naive pluripotency through Neo1 and Unc5b co-regulation of Wnt and MAPK signalling Nat. Cell Biol. (IF 17.728) Pub Date : 2020-03-30 Aurélia Huyghe; Giacomo Furlan; Duygu Ozmadenci; Christina Galonska; Jocelyn Charlton; Xavier Gaume; Noémie Combémorel; Christina Riemenschneider; Nicolas Allègre; Jenny Zhang; Pauline Wajda; Nicolas Rama; Pauline Vieugué; Isabelle Durand; Marie Brevet; Nicolas Gadot; Thomas Imhof; Bradley J. Merrill; Manuel Koch; Patrick Mehlen; Claire Chazaud; Alexander Meissner; Fabrice Lavial
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Single-cell chromatin accessibility maps reveal regulatory programs driving early mouse organogenesis Nat. Cell Biol. (IF 17.728) Pub Date : 2020-03-30 Blanca Pijuan-Sala; Nicola K. Wilson; Jun Xia; Xiaomeng Hou; Rebecca L. Hannah; Sarah Kinston; Fernando J. Calero-Nieto; Olivier Poirion; Sebastian Preissl; Feng Liu; Berthold Göttgens
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Pro-neuronal activity of Myod1 due to promiscuous binding to neuronal genes Nat. Cell Biol. (IF 17.728) Pub Date : 2020-03-30 Qian Yi Lee; Moritz Mall; Soham Chanda; Bo Zhou; Kylesh S. Sharma; Katie Schaukowitch; Juan M. Adrian-Segarra; Sarah D. Grieder; Michael S. Kareta; Orly L. Wapinski; Cheen Euong Ang; Rui Li; Thomas C. Südhof; Howard Y. Chang; Marius Wernig
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RNA helicase DDX21 mediates nucleotide stress responses in neural crest and melanoma cells Nat. Cell Biol. (IF 17.728) Pub Date : 2020-03-30 Cristina Santoriello; Audrey Sporrij; Song Yang; Ryan A. Flynn; Telmo Henriques; Bilguujin Dorjsuren; Eugenia Custo Greig; Wyatt McCall; Meredith E. Stanhope; Maurizio Fazio; Michael Superdock; Asher Lichtig; Isaac Adatto; Brian J. Abraham; Marian Kalocsay; Michael Jurynec; Yi Zhou; Karen Adelman; Eliezer Calo; Leonard I. Zon
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Setting the chromatin stage in oocytes Nat. Cell Biol. (IF 17.728) Pub Date : 2020-03-30 Julie Brind’Amour; Matthew C. Lorincz
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Phase separation of TAZ compartmentalizes the transcription machinery to promote gene expression Nat. Cell Biol. (IF 17.728) Pub Date : 2020-03-23 Yi Lu; Tiantian Wu; Orit Gutman; Huasong Lu; Qiang Zhou; Yoav I. Henis; Kunxin Luo
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YAP/TAZ phase separation for transcription Nat. Cell Biol. (IF 17.728) Pub Date : 2020-03-23 J. Matthew Franklin; Kun-Liang Guan
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Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions Nat. Cell Biol. (IF 17.728) Pub Date : 2020-03-23 Paul M. Müller; Juliane Rademacher; Richard D. Bagshaw; Celina Wortmann; Carolin Barth; Jakobus van Unen; Keziban M. Alp; Girolamo Giudice; Rebecca L. Eccles; Louise E. Heinrich; Patricia Pascual-Vargas; Marta Sanchez-Castro; Lennart Brandenburg; Geraldine Mbamalu; Monika Tucholska; Lisa Spatt; Maciej T. Czajkowski; Robert-William Welke; Sunqu Zhang; Vivian Nguyen; Trendelina Rrustemi; Philipp Trnka;
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RYBP/YAF2-PRC1 complexes and histone H1-dependent chromatin compaction mediate propagation of H2AK119ub1 during cell division Nat. Cell Biol. (IF 17.728) Pub Date : 2020-03-23 Jicheng Zhao; Min Wang; Luyuan Chang; Juan Yu; Aoqun Song; Cuifang Liu; Wenjun Huang; Tiantian Zhang; Xudong Wu; Xiaohua Shen; Bing Zhu; Guohong Li
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Epigenetic remodelling shapes inflammatory renal cancer and neutrophil-dependent metastasis Nat. Cell Biol. (IF 17.728) Pub Date : 2020-03-23 Jun Nishida; Yusaku Momoi; Kosuke Miyakuni; Yusuke Tamura; Kei Takahashi; Daizo Koinuma; Kohei Miyazono; Shogo Ehata
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piRNA-unbound PIWIL1 promotes metastasis Nat. Cell Biol. (IF 17.728) Pub Date : 2020-03-18 Fan Yao; Li Ma
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Copper is an essential regulator of the autophagic kinases ULK1/2 to drive lung adenocarcinoma Nat. Cell Biol. (IF 17.728) Pub Date : 2020-03-16 Tiffany Tsang; Jessica M. Posimo; Andrea A. Gudiel; Michelle Cicchini; David M. Feldser; Donita C. Brady
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piRNA-independent function of PIWIL1 as a co-activator for anaphase promoting complex/cyclosome to drive pancreatic cancer metastasis Nat. Cell Biol. (IF 17.728) Pub Date : 2020-03-16 Feng Li; Peng Yuan; Ming Rao; Chun-Hui Jin; Wei Tang; Ye-Fei Rong; Yun-Ping Hu; Fengjuan Zhang; Tao Wei; Qi Yin; Tingbo Liang; Ligang Wu; Jinsong Li; Dangsheng Li; Yingbin Liu; Wenhui Lou; Shuang Zhao; Mo-Fang Liu
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Transcriptional diversity and bioenergetic shift in human breast cancer metastasis revealed by single-cell RNA sequencing. Nat. Cell Biol. (IF 17.728) Pub Date : 2020-03-06 Ryan T Davis,Kerrigan Blake,Dennis Ma,Mari B Ishak Gabra,Grace A Hernandez,Anh T Phung,Ying Yang,Dustin Maurer,Austin E Y T Lefebvre,Hamad Alshetaiwi,Zhengtao Xiao,Juan Liu,Jason W Locasale,Michelle A Digman,Eric Mjolsness,Mei Kong,Zena Werb,Devon A Lawson
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Long-term, in toto live imaging of cardiomyocyte behaviour during mouse ventricle chamber formation at single-cell resolution. Nat. Cell Biol. (IF 17.728) Pub Date : 2020-03-02 Yanzhu Yue,Weijian Zong,Xin Li,Jinghang Li,Youdong Zhang,Runlong Wu,Yazui Liu,Jiahao Cui,Qianhao Wang,Yunkun Bian,Xianhong Yu,Yao Liu,Guangming Tan,Yunfeng Zhang,Gang Zhao,Bin Zhou,Liangyi Chen,Wenlei Xiao,Heping Cheng,Aibin He
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Engineering human knock-in organoids. Nat. Cell Biol. (IF 17.728) Pub Date : 2020-03-02 Qiutan Yang,Koen C Oost,Prisca Liberali
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Fast and efficient generation of knock-in human organoids using homology-independent CRISPR-Cas9 precision genome editing. Nat. Cell Biol. (IF 17.728) Pub Date : 2020-03-02 Benedetta Artegiani,Delilah Hendriks,Joep Beumer,Rutger Kok,Xuan Zheng,Indi Joore,Susana Chuva de Sousa Lopes,Jeroen van Zon,Sander Tans,Hans Clevers
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Unlocking the door for ERAD. Nat. Cell Biol. (IF 17.728) Pub Date : 2020-02-26 Miguel Betegon,Jeffrey L Brodsky
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Hrd1 forms the retrotranslocation pore regulated by auto-ubiquitination and binding of misfolded proteins Nat. Cell Biol. (IF 17.728) Pub Date : 2020-02-24 Vedran Vasic; Niels Denkert; Claudia C. Schmidt; Dietmar Riedel; Alexander Stein; Michael Meinecke
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Crosstalk with lung epithelial cells regulates Sfrp2 -mediated latency in breast cancer dissemination Nat. Cell Biol. (IF 17.728) Pub Date : 2020-02-24 Marco Montagner; Rahul Bhome; Steven Hooper; Probir Chakravarty; Xiao Qin; Jahangir Sufi; Ajay Bhargava; Colin D. H. Ratcliffe; Yutaka Naito; Arianna Pocaterra; Christopher J. Tape; Erik Sahai
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Optimising gene editing for cancer therapy. Nat. Cell Biol. (IF 17.728) Pub Date : 2020-02-21 Katie Troike,Justin D Lathia
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Optogenetic control of mRNA localization and translation in live cells. Nat. Cell Biol. (IF 17.728) Pub Date : 2020-02-17 Na Yeon Kim,Sangkyu Lee,Jeonghye Yu,Nury Kim,Seong Su Won,Hyerim Park,Won Do Heo
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Author Correction: Ribosomes guide pachytene piRNA formation on long intergenic piRNA precursors. Nat. Cell Biol. (IF 17.728) Pub Date : 2020-02-17 Yu H Sun,Jiang Zhu,Li Huitong Xie,Ziwei Li,Rajyalakshmi Meduri,Xiaopeng Zhu,Chi Song,Chen Chen,Emiliano P Ricci,Zhiping Weng,Xin Zhiguo Li
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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A perinuclear microtubule-organizing centre controls nuclear positioning and basement membrane secretion. Nat. Cell Biol. (IF 17.728) Pub Date : 2020-02-17 Yiming Zheng,Rebecca A Buchwalter,Chunfeng Zheng,Elise M Wight,Jieyan V Chen,Timothy L Megraw
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Programmable base editing of mutated TERT promoter inhibits brain tumour growth. Nat. Cell Biol. (IF 17.728) Pub Date : 2020-02-17 Xinjian Li,Xu Qian,Bin Wang,Yan Xia,Yanhua Zheng,Linyong Du,Daqian Xu,Dongming Xing,Ronald A DePinho,Zhimin Lu
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Author Correction: Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms. Nat. Cell Biol. (IF 17.728) Pub Date : 2020-02-10 Halil Bagci,Neera Sriskandarajah,Amélie Robert,Jonathan Boulais,Islam E Elkholi,Viviane Tran,Zhen-Yuan Lin,Marie-Pier Thibault,Nadia Dubé,Denis Faubert,David R Hipfner,Anne-Claude Gingras,Jean-François Côté
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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A negative-feedback loop maintains optimal chemokine concentrations for directional cell migration. Nat. Cell Biol. (IF 17.728) Pub Date : 2020-02-10 Stephanie Lau,Anna Feitzinger,Gayatri Venkiteswaran,John Wang,Stephen W Lewellis,Chad A Koplinski,Francis C Peterson,Brian F Volkman,Martin Meier-Schellersheim,Holger Knaut
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Selective autophagy degrades nuclear pore complexes. Nat. Cell Biol. (IF 17.728) Pub Date : 2020-02-06 Chia-Wei Lee,Florian Wilfling,Paolo Ronchi,Matteo Allegretti,Shyamal Mosalaganti,Stefan Jentsch,Martin Beck,Boris Pfander
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Energy-stress-mediated AMPK activation inhibits ferroptosis. Nat. Cell Biol. (IF 17.728) Pub Date : 2020-02-06 Hyemin Lee,Fereshteh Zandkarimi,Yilei Zhang,Jitendra Kumar Meena,Jongchan Kim,Li Zhuang,Siddhartha Tyagi,Li Ma,Thomas F Westbrook,Gregory R Steinberg,Daisuke Nakada,Brent R Stockwell,Boyi Gan
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The KRAS-BCAA-BCAT2 axis in PDAC development. Nat. Cell Biol. (IF 17.728) Pub Date : 2020-02-01 Mattia Falcone,Oliver D K Maddocks
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BCAT2-mediated BCAA catabolism is critical for development of pancreatic ductal adenocarcinoma. Nat. Cell Biol. (IF 17.728) Pub Date : 2020-02-06 Jin-Tao Li,Miao Yin,Di Wang,Jian Wang,Ming-Zhu Lei,Ye Zhang,Ying Liu,Lei Zhang,Shao-Wu Zou,Li-Peng Hu,Zhi-Gang Zhang,Yi-Ping Wang,Wen-Yu Wen,Hao-Jie Lu,Zheng-Jun Chen,Dan Su,Qun-Ying Lei
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LATS suppresses mTORC1 activity to directly coordinate Hippo and mTORC1 pathways in growth control. Nat. Cell Biol. (IF 17.728) Pub Date : 2020-02-03 Wenjian Gan,Xiaoming Dai,Xiangpeng Dai,Jun Xie,Shasha Yin,Junjie Zhu,Chen Wang,Yuchen Liu,Jianping Guo,Min Wang,Jing Liu,Jia Hu,Ryan J Quinton,Neil J Ganem,Pengda Liu,John M Asara,Pier Paolo Pandolfi,Yingzi Yang,Zhigang He,Guangping Gao,Wenyi Wei
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RNA-targeting CRISPR systems from metagenomic discovery to transcriptomic engineering. Nat. Cell Biol. (IF 17.728) Pub Date : 2020-02-03 Aaron A Smargon,Yilan J Shi,Gene W Yeo
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Ribosomes guide pachytene piRNA formation on long intergenic piRNA precursors. Nat. Cell Biol. (IF 17.728) Pub Date : 2020-02-03 Yu H Sun,Jiang Zhu,Li Huitong Xie,Ziwei Li,Rajyalakshmi Meduri,Xiaopeng Zhu,Chi Song,Chen Chen,Emiliano P Ricci,Zhiping Weng,Xin Zhiguo Li
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Ribosome-guided piRNA production. Nat. Cell Biol. (IF 17.728) Pub Date : 2020-02-03 Yuanhui Mao,Shu-Bing Qian
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Small-RNA-mediated transgenerational silencing of histone genes impairs fertility in piRNA mutants. Nat. Cell Biol. (IF 17.728) Pub Date : 2020-02-03 Giorgia Barucci,Eric Cornes,Meetali Singh,Blaise Li,Martino Ugolini,Aleksei Samolygo,Celine Didier,Florent Dingli,Damarys Loew,Piergiuseppe Quarato,Germano Cecere
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HSF1 phase transition mediates stress adaptation and cell fate decisions. Nat. Cell Biol. (IF 17.728) Pub Date : 2020-02-03 Giorgio Gaglia,Rumana Rashid,Clarence Yapp,Gaurav N Joshi,Carmen G Li,Susan L Lindquist,Kristopher A Sarosiek,Luke Whitesell,Peter K Sorger,Sandro Santagata
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L(C3)icensing of exosomes for RNA export. Nat. Cell Biol. (IF 17.728) Pub Date : 2020-01-28 Janusz Rak
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FERARI is required for Rab11-dependent endocytic recycling. Nat. Cell Biol. (IF 17.728) Pub Date : 2020-01-27 Jachen A Solinger,Harun-Or Rashid,Cristina Prescianotto-Baschong,Anne Spang
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Author Correction: Dynamic responses of the haematopoietic stem cell niche to diverse stresses. Nat. Cell Biol. (IF 17.728) Pub Date : 2020-01-22 Antoniana Batsivari,Myriam Luydmila Rachelle Haltalli,Diana Passaro,Constandina Pospori,Cristina Lo Celso,Dominique Bonnet
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Maternal factor NELFA drives a 2C-like state in mouse embryonic stem cells. Nat. Cell Biol. (IF 17.728) Pub Date : 2020-01-13 Zhenhua Hu,Dennis Eng Kiat Tan,Gloryn Chia,Haihan Tan,Hwei Fen Leong,Benjamin Jieming Chen,Mei Sheng Lau,Kelly Yu Sing Tan,Xuezhi Bi,Dongxiao Yang,Ying Swan Ho,Baojiang Wu,Siqin Bao,Esther Sook Miin Wong,Wee-Wei Tee
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The LC3-conjugation machinery specifies the loading of RNA-binding proteins into extracellular vesicles. Nat. Cell Biol. (IF 17.728) Pub Date : 2020-01-13 Andrew M Leidal,Hector H Huang,Timothy Marsh,Tina Solvik,Dachuan Zhang,Jordan Ye,FuiBoon Kai,Juliet Goldsmith,Jennifer Y Liu,Yu-Hsin Huang,Teresa Monkkonen,Ariadne Vlahakis,Eric J Huang,Hani Goodarzi,Li Yu,Arun P Wiita,Jayanta Debnath
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TRIP13 regulates DNA repair pathway choice through REV7 conformational change. Nat. Cell Biol. (IF 17.728) Pub Date : 2020-01-08 Connor S Clairmont,Prabha Sarangi,Karthikeyan Ponnienselvan,Lucas D Galli,Isabelle Csete,Lisa Moreau,Guillaume Adelmant,Dipanjan Chowdhury,Jarrod A Marto,Alan D D'Andrea
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Single-cell reconstruction of the adult human heart during heart failure and recovery reveals the cellular landscape underlying cardiac function. Nat. Cell Biol. (IF 17.728) Pub Date : 2020-01-08 Li Wang,Peng Yu,Bingying Zhou,Jiangping Song,Zheng Li,Mingzhi Zhang,Guangran Guo,Yin Wang,Xiao Chen,Leng Han,Shengshou Hu
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Clock regulation of protein secretion. Nat. Cell Biol. (IF 17.728) Pub Date : 2020-01-06 Thomas P Burris
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Erythromyeloid progenitors give rise to a population of osteoclasts that contribute to bone homeostasis and repair. Nat. Cell Biol. (IF 17.728) Pub Date : 2020-01-06 Yasuhito Yahara,Tomasa Barrientos,Yuning J Tang,Vijitha Puviindran,Puviindran Nadesan,Hongyuan Zhang,Jason R Gibson,Simon G Gregory,Yarui Diao,Yu Xiang,Yawar J Qadri,Tomokazu Souma,Mari L Shinohara,Benjamin A Alman
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Dynamic responses of the haematopoietic stem cell niche to diverse stresses. Nat. Cell Biol. (IF 17.728) Pub Date : 2020-01-06 Antoniana Batsivari,Myriam Luydmila Rachelle Haltalli,Diana Passaro,Constandina Pospori,Cristina Lo Celso,Dominique Bonnet
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p120-catenin-dependent collective brain infiltration by glioma cell networks. Nat. Cell Biol. (IF 17.728) Pub Date : 2020-01-06 Pavlo G Gritsenko,Nader Atlasy,Cindy E J Dieteren,Anna C Navis,Jan-Hendrik Venhuizen,Cornelia Veelken,Dirk Schubert,Amparo Acker-Palmer,Bart A Westerman,Thomas Wurdinger,William Leenders,Pieter Wesseling,Hendrik G Stunnenberg,Peter Friedl
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Circadian control of the secretory pathway maintains collagen homeostasis. Nat. Cell Biol. (IF 17.728) Pub Date : 2020-01-06 Joan Chang,Richa Garva,Adam Pickard,Ching-Yan Chloé Yeung,Venkatesh Mallikarjun,Joe Swift,David F Holmes,Ben Calverley,Yinhui Lu,Antony Adamson,Helena Raymond-Hayling,Oliver Jensen,Tom Shearer,Qing Jun Meng,Karl E Kadler
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Multipotent RAG1+ progenitors emerge directly from haemogenic endothelium in human pluripotent stem cell-derived haematopoietic organoids. Nat. Cell Biol. (IF 17.728) Pub Date : 2020-01-06 Ali Motazedian,Freya F Bruveris,Santhosh V Kumar,Jacqueline V Schiesser,Tyrone Chen,Elizabeth S Ng,Ann P Chidgey,Christine A Wells,Andrew G Elefanty,Edouard G Stanley
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Publisher Correction: STRIPAK integrates upstream signals to initiate the Hippo kinase cascade. Nat. Cell Biol. (IF 17.728) Pub Date : 2020-01-02 Rui Chen,Ruiling Xie,Zhipeng Meng,Shenghong Ma,Kun-Liang Guan
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Unraveling bone marrow architecture. Nat. Cell Biol. (IF 17.728) Pub Date : 2019-12-23 Daniel Lucas,Nathan Salomonis,H Leighton Grimes
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Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms. Nat. Cell Biol. (IF 17.728) Pub Date : 2019-12-23 Halil Bagci,Neera Sriskandarajah,Amélie Robert,Jonathan Boulais,Islam E Elkholi,Viviane Tran,Zhen-Yuan Lin,Marie-Pier Thibault,Nadia Dubé,Denis Faubert,David R Hipfner,Anne-Claude Gingras,Jean-François Côté
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Endfoot regrowth for neural stem cell renewal. Nat. Cell Biol. (IF 17.728) Pub Date : 2019-12-23 Masafumi Tsuboi,Yukiko Gotoh
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Endfoot regeneration restricts radial glial state and prevents translocation into the outer subventricular zone in early mammalian brain development. Nat. Cell Biol. (IF 17.728) Pub Date : 2019-12-23 Ikumi Fujita,Atsunori Shitamukai,Fumiya Kusumoto,Shun Mase,Taeko Suetsugu,Ayaka Omori,Kagayaki Kato,Takaya Abe,Go Shioi,Daijiro Konno,Fumio Matsuzaki
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