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Fasting shapes chromatin architecture through an mTOR/RNA Pol I axis Nat. Cell Biol. (IF 17.3) Pub Date : 2024-09-19 Nada Al-Refaie, Francesco Padovani, Johanna Hornung, Lorenz Pudelko, Francesca Binando, Andrea del Carmen Fabregat, Qiuxia Zhao, Benjamin D. Towbin, Elif Sarinay Cenik, Nicholas Stroustrup, Jan Padeken, Kurt M. Schmoller, Daphne S. Cabianca
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Clathrin-associated carriers enable recycling through a kiss-and-run mechanism Nat. Cell Biol. (IF 17.3) Pub Date : 2024-09-19 Jiachao Xu, Yu Liang, Nan Li, Song Dang, Amin Jiang, Yiqun Liu, Yuting Guo, Xiaoyu Yang, Yi Yuan, Xinyi Zhang, Yaran Yang, Yongtao Du, Anbing Shi, Xiaoyun Liu, Dong Li, Kangmin He
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Plasma membrane curvature regulates the formation of contacts with the endoplasmic reticulum Nat. Cell Biol. (IF 17.3) Pub Date : 2024-09-17 Yang Yang, Luis A. Valencia, Chih-Hao Lu, Melissa L. Nakamoto, Ching-Ting Tsai, Chun Liu, Huaxiao Yang, Wei Zhang, Zeinab Jahed, Wan-Ru Lee, Francesca Santoro, Jen Liou, Joseph C. Wu, Bianxiao Cui
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Mitophagy protects against ferroptosis Nat. Cell Biol. (IF 17.3) Pub Date : 2024-09-12 Petra Gross
Mitophagy, the selective autophagy of damaged mitochondria, is mediated by several receptors, including BNIP3 and NIX, and is important for mitochondrial homeostasis. Mitochondria are also the major source of reactive oxygen species (ROS); mitochondrial ROS (mtROS) can give rise to lipid peroxides, which, in turn, induce ferroptosis, a specific type of cell death. In this study, Kanki and co-workers
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Profiling cell death in COVID-19 pathology Nat. Cell Biol. (IF 17.3) Pub Date : 2024-09-12 Zhe Wang
SARS-CoV-2 infection can lead to various types of cell death including apoptosis, necroptosis and pyroptosis. Liang et al. report the dynamics and features of cell death in infected human airway epithelial cells, the primary target cell type that hosts SARS-CoV-2 replication. The authors first showed that SARS-CoV-2 infection in ACE2-expressing lung epithelial cells initially induced apoptosis and
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Ribotoxic stress drives cell death by UV Nat. Cell Biol. (IF 17.3) Pub Date : 2024-09-12 Petra Gross
UV radiation not only induces DNA damage, but also damages RNA, eliciting a ribotoxic stress response (RSR), but its contribution to subsequent cell death remains unclear. Green and colleagues establish a detailed timeline of signalling events activated in cells upon UV damage and report that UV-mediated apoptosis is driven by RSR, and not the DNA damage response. The authors show that the immediate-early
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Ferroptosis disseminates afar in development Nat. Cell Biol. (IF 17.3) Pub Date : 2024-09-12 Zhe Wang
Ferroptosis is a distinct form of iron-dependent cell death that can propagate over a distance through a population of cells in a wave-like process. Co et al. further characterize this phenomenon and report ferroptotic trigger waves as a large-scale cell death mechanism to control limb development. The authors developed a cellular system to pinpoint the time and location of ferroptosis induction through
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Navigating the biology of cell death Nat. Cell Biol. (IF 17.3) Pub Date : 2024-09-12
This issue presents a Focus of specially commissioned articles that discuss cell death in its multiple forms, implications for homeostatic physiology and disease and outstanding questions in this expanding field.
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Solid tumour-induced systemic immunosuppression involves dichotomous myeloid–B cell interactions Nat. Cell Biol. (IF 17.3) Pub Date : 2024-09-12 Xiaoxin Hao, Yichao Shen, Jun Liu, Angela Alexander, Ling Wu, Zhan Xu, Liqun Yu, Yang Gao, Fengshuo Liu, Hilda L. Chan, Che-Hsing Li, Yunfeng Ding, Weijie Zhang, David G. Edwards, Nan Chen, Azadeh Nasrazadani, Naoto T. Ueno, Bora Lim, Xiang H.-F. Zhang
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The Polycomb system sustains promoters in a deep OFF state by limiting pre-initiation complex formation to counteract transcription Nat. Cell Biol. (IF 17.3) Pub Date : 2024-09-11 Aleksander T. Szczurek, Emilia Dimitrova, Jessica R. Kelley, Neil P. Blackledge, Robert J. Klose
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Ammonia-induced lysosomal and mitochondrial damage causes cell death of effector CD8+ T cells Nat. Cell Biol. (IF 17.3) Pub Date : 2024-09-11 Huafeng Zhang, Jincheng Liu, Wu Yuan, Qian Zhang, Xiao Luo, Yonggang Li, Yue’e Peng, Jingyu Feng, Xiaoyu Liu, Jie Chen, Yabo Zhou, Jiadi Lv, Nannan Zhou, Jingwei Ma, Ke Tang, Bo Huang
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Inverse blebs operate as hydraulic pumps during mouse blastocyst formation Nat. Cell Biol. (IF 17.3) Pub Date : 2024-09-11 Markus F. Schliffka, Julien G. Dumortier, Diane Pelzer, Arghyadip Mukherjee, Jean-Léon Maître
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Perturbing TET2 condensation promotes aberrant genome-wide DNA methylation and curtails leukaemia cell growth Nat. Cell Biol. (IF 17.3) Pub Date : 2024-09-09 Lei Guo, Tingting Hong, Yi-Tsang Lee, Xue Hu, Guokai Pan, Rongjie Zhao, Yuhan Yang, Jingwen Yang, Xiaoli Cai, Logan Rivera, Jie Liang, Rui Wang, Yaling Dou, Srikanth Kodali, Wenbo Li, Leng Han, Bruno Di Stefano, Yubin Zhou, Jia Li, Yun Huang
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A size filter at the Golgi regulates apical membrane protein sorting Nat. Cell Biol. (IF 17.3) Pub Date : 2024-09-05 Christian de Caestecker, Ian G. Macara
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Wnt-deficient and hypoxic environment orchestrates squamous reprogramming of human pancreatic ductal adenocarcinoma Nat. Cell Biol. (IF 17.3) Pub Date : 2024-09-04 Hiroki Tamagawa, Masayuki Fujii, Kazuhiro Togasaki, Takashi Seino, Shintaro Kawasaki, Ai Takano, Kohta Toshimitsu, Sirirat Takahashi, Yuki Ohta, Mami Matano, Kenta Kawasaki, Yujiro Machida, Shigeki Sekine, Akihito Machinaga, Ken Sasai, Yuzo Kodama, Nobuyuki Kakiuchi, Seishi Ogawa, Tomonori Hirano, Hiroshi Seno, Minoru Kitago, Yuko Kitagawa, Eisuke Iwasaki, Takanori Kanai, Toshiro Sato
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HSF1 renders NK cells too stressed to respond Nat. Cell Biol. (IF 17.3) Pub Date : 2024-09-02 Yael Gruper, Aviad Ben-Shmuel, Ruth Scherz-Shouval
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Criteria for the standardization of stem-cell-based embryo models Nat. Cell Biol. (IF 17.3) Pub Date : 2024-09-02 Alfonso Martinez Arias, Nicolas Rivron, Naomi Moris, Patrick Tam, Cantas Alev, Jianping Fu, Anna-Katerina Hadjantonakis, Jacob H. Hanna, Gabriella Minchiotti, Olivier Pourquie, Guojun Sheng, Liliana Solnica Krezel, Jesse V. Veenvliet, Aryeh Warmflash
Pluripotent stem cells are being used to generate models of early embryogenesis that are promising for discovery and translational research. To be useful, these models require critical consideration of their level of efficiency and fidelity to natural embryos. Here we propose criteria with which to raise the standards of stem-cell-based embryo models of human embryogenesis.
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The stress response regulator HSF1 modulates natural killer cell anti-tumour immunity Nat. Cell Biol. (IF 17.3) Pub Date : 2024-09-02 Kathryn Hockemeyer, Theodore Sakellaropoulos, Xufeng Chen, Olha Ivashkiv, Maria Sirenko, Hua Zhou, Giovanni Gambi, Elena Battistello, Kleopatra Avrampou, Zhengxi Sun, Maria Guillamot, Luis Chiriboga, George Jour, Igor Dolgalev, Kate Corrigan, Kamala Bhatt, Iman Osman, Aristotelis Tsirigos, Nikos Kourtis, Iannis Aifantis
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Innate immune sensing of cell death in disease and therapeutics Nat. Cell Biol. (IF 17.3) Pub Date : 2024-09-02 Si Ming Man, Thirumala-Devi Kanneganti
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Noncanonical inheritance of phenotypic information by protein amyloids Nat. Cell Biol. (IF 17.3) Pub Date : 2024-09-02 Matthew Eroglu, Tanner Zocher, Jacob McAuley, Rachel Webster, Maggie Z. X. Xiao, Bin Yu, Calvin Mok, W. Brent Derry
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LIANA+ provides an all-in-one framework for cell–cell communication inference Nat. Cell Biol. (IF 17.3) Pub Date : 2024-09-02 Daniel Dimitrov, Philipp Sven Lars Schäfer, Elias Farr, Pablo Rodriguez-Mier, Sebastian Lobentanzer, Pau Badia-i-Mompel, Aurelien Dugourd, Jovan Tanevski, Ricardo Omar Ramirez Flores, Julio Saez-Rodriguez
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A phosphorylation-controlled switch confers cell cycle-dependent protein relocalization Nat. Cell Biol. (IF 17.3) Pub Date : 2024-08-29 Xiaofu Cao, Shiying Huang, Mateusz M. Wagner, Yuan-Ting Cho, Din-Chi Chiu, Krista M. Wartchow, Artur Lazarian, Laura Beth McIntire, Marcus B. Smolka, Jeremy M. Baskin
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Nuclear proteasomes buffer cytoplasmic proteins during autophagy compromise Nat. Cell Biol. (IF 17.3) Pub Date : 2024-08-29 So Jung Park, Sung Min Son, Antonio Daniel Barbosa, Lidia Wrobel, Eleanna Stamatakou, Ferdinando Squitieri, Gabriel Balmus, David C. Rubinsztein
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The dual roles of lymphotoxin-β in promoting breast cancer bone metastasis Nat. Cell Biol. (IF 17.3) Pub Date : 2024-08-28
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Single-cell new RNA sequencing reveals principles of transcription at the resolution of individual bursts Nat. Cell Biol. (IF 17.3) Pub Date : 2024-08-28 Daniel Ramsköld, Gert-Jan Hendriks, Anton J. M. Larsson, Juliane V. Mayr, Christoph Ziegenhain, Michael Hagemann-Jensen, Leonard Hartmanis, Rickard Sandberg
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Gasdermins as evolutionarily conserved executors of inflammation and cell death Nat. Cell Biol. (IF 17.3) Pub Date : 2024-08-26 Kaiwen W. Chen, Petr Broz
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Adaptive microtubule reinforcement enables cell migration through 3D environments Nat. Cell Biol. (IF 17.3) Pub Date : 2024-08-23
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Exosome regulation by Rubicon in ageing Nat. Cell Biol. (IF 17.3) Pub Date : 2024-08-22 Yan Zhen, Harald Stenmark
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The Rubicon–WIPI axis regulates exosome biogenesis during ageing Nat. Cell Biol. (IF 17.3) Pub Date : 2024-08-22 Kyosuke Yanagawa, Akiko Kuma, Maho Hamasaki, Shunbun Kita, Tadashi Yamamuro, Kohei Nishino, Shuhei Nakamura, Hiroko Omori, Tatsuya Kaminishi, Satoshi Oikawa, Yoshio Kato, Ryuya Edahiro, Ryosuke Kawagoe, Takako Taniguchi, Yoko Tanaka, Takayuki Shima, Keisuke Tabata, Miki Iwatani, Nao Bekku, Rikinari Hanayama, Yukinori Okada, Takayuki Akimoto, Hidetaka Kosako, Akiko Takahashi, Iichiro Shimomura, Yasushi
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RNA sequestration in P-bodies sustains myeloid leukaemia Nat. Cell Biol. (IF 17.3) Pub Date : 2024-08-21 Srikanth Kodali, Ludovica Proietti, Gemma Valcarcel, Anna V. López-Rubio, Patrizia Pessina, Thomas Eder, Junchao Shi, Annie Jen, Núria Lupión-Garcia, Anne C. Starner, Mason D. Bartels, Yingzhi Cui, Caroline M. Sands, Ainoa Planas-Riverola, Alba Martínez, Talia Velasco-Hernandez, Laureano Tomás-Daza, Bernhard Alber, Gabriele Manhart, Isabella Maria Mayer, Karoline Kollmann, Alessandro Fatica, Pablo
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Retinoic acid induces human gastruloids with posterior embryo-like structures Nat. Cell Biol. (IF 17.3) Pub Date : 2024-08-20 Nobuhiko Hamazaki, Wei Yang, Connor A. Kubo, Chengxiang Qiu, Beth K. Martin, Riddhiman K. Garge, Samuel G. Regalado, Eva K. Nichols, Sriram Pendyala, Nicholas Bradley, Douglas M. Fowler, Choli Lee, Riza M. Daza, Sanjay Srivatsan, Jay Shendure
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Compression-dependent microtubule reinforcement enables cells to navigate confined environments Nat. Cell Biol. (IF 17.3) Pub Date : 2024-08-19 Robert J. Ju, Alistair D. Falconer, Christanny J. Schmidt, Marco A. Enriquez Martinez, Kevin M. Dean, Reto P. Fiolka, David P. Sester, Max Nobis, Paul Timpson, Alexis J. Lomakin, Gaudenz Danuser, Melanie D. White, Nikolas K. Haass, Dietmar B. Oelz, Samantha J. Stehbens
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Lymphotoxin-β promotes breast cancer bone metastasis colonization and osteolytic outgrowth Nat. Cell Biol. (IF 17.3) Pub Date : 2024-08-15 Xuxiang Wang, Tengjiang Zhang, Bingxin Zheng, Youxue Lu, Yong Liang, Guoyuan Xu, Luyang Zhao, Yuwei Tao, Qianhui Song, Huiwen You, Haitian Hu, Xuan Li, Keyong Sun, Tianqi Li, Zian Zhang, Jianbin Wang, Xun Lan, Deng Pan, Yang-Xin Fu, Bin Yue, Hanqiu Zheng
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A fatty acid switch drives ferroptosis in EMT Nat. Cell Biol. (IF 17.3) Pub Date : 2024-08-13 Alina M. Winkelkotte, Almut Schulze
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Docking a flexible basket onto the core of the nuclear pore complex Nat. Cell Biol. (IF 17.3) Pub Date : 2024-08-13 Edvinas Stankunas, Alwin Köhler
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Spermidine is essential for fasting-mediated autophagy and longevity Nat. Cell Biol. (IF 17.3) Pub Date : 2024-08-08 Sebastian J. Hofer, Ioanna Daskalaki, Martina Bergmann, Jasna Friščić, Andreas Zimmermann, Melanie I. Mueller, Mahmoud Abdellatif, Raffaele Nicastro, Sarah Masser, Sylvère Durand, Alexander Nartey, Mara Waltenstorfer, Sarah Enzenhofer, Isabella Faimann, Verena Gschiel, Thomas Bajaj, Christine Niemeyer, Ilias Gkikas, Lukas Pein, Giulia Cerrato, Hui Pan, YongTian Liang, Jelena Tadic, Andrea Jerkovic
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TorsinA is essential for neuronal nuclear pore complex localization and maturation Nat. Cell Biol. (IF 17.3) Pub Date : 2024-08-08 Sumin Kim, Sébastien Phan, Hung Tri Tran, Thomas R. Shaw, Sarah H. Shahmoradian, Mark H. Ellisman, Sarah L. Veatch, Sami J. Barmada, Samuel S. Pappas, William T. Dauer
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Spindle architecture constrains karyotype evolution Nat. Cell Biol. (IF 17.3) Pub Date : 2024-08-08 Jana Helsen, Md Hashim Reza, Ricardo Carvalho, Gavin Sherlock, Gautam Dey
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p16-dependent increase of PD-L1 stability regulates immunosurveillance of senescent cells Nat. Cell Biol. (IF 17.3) Pub Date : 2024-08-05 Julia Majewska, Amit Agrawal, Avi Mayo, Lior Roitman, Rishita Chatterjee, Jarmila Sekeresova Kralova, Tomer Landsberger, Yonatan Katzenelenbogen, Tomer Meir-Salame, Efrat Hagai, Ilanit Sopher, Juan-Felipe Perez-Correa, Wolfgang Wagner, Avi Maimon, Ido Amit, Uri Alon, Valery Krizhanovsky
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Systematic loss-of-function screens identify pathway-specific functional circular RNAs Nat. Cell Biol. (IF 17.3) Pub Date : 2024-08-02 Ling Liu, Matthew Neve, Laura Perlaza-Jimenez, Xinqi Xi, Jacob Purcell, Azelle Hawdon, Simon J. Conn, Jennifer Zenker, Pablo Tamayo, Gregory J. Goodall, Joseph Rosenbluh
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Cleavage-independent GSDME activation by UVC Nat. Cell Biol. (IF 17.3) Pub Date : 2024-07-31 Ellie Zhang, Liam Healy, Gang Du, Hao Wu
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Distinct dynamics of parental 5-hydroxymethylcytosine during human preimplantation development regulate early lineage gene expression Nat. Cell Biol. (IF 17.3) Pub Date : 2024-07-30 Dan Liang, Rui Yan, Xin Long, Dongmei Ji, Bing Song, Mengyao Wang, Fan Zhang, Xin Cheng, Fengyuan Sun, Ran Zhu, Xinling Hou, Tianjuan Wang, Weiwei Zou, Ying Zhang, Zhixin Pu, Jing Zhang, Zhiguo Zhang, Yajing Liu, Yuqiong Hu, Xiaojin He, Yunxia Cao, Fan Guo
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mTORC2-driven chromatin cGAS mediates chemoresistance through epigenetic reprogramming in colorectal cancer Nat. Cell Biol. (IF 17.3) Pub Date : 2024-07-30 Guoqing Lv, Qian Wang, Lin Lin, Qiao Ye, Xi Li, Qian Zhou, Xiangzhen Kong, Hongxia Deng, Fuping You, Hebing Chen, Song Wu, Lin Yuan
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Trafficking circuit of CD8+ T cells between the intestine and bone marrow governs antitumour immunity Nat. Cell Biol. (IF 17.3) Pub Date : 2024-07-22 Rong-Yi Shi, Neng Zhou, Li Xuan, Zhong-Hui Jiang, Jing Xia, Jian-Min Zhu, Kai-Ming Chen, Guo-Li Zhou, Guo-Pan Yu, Jun Zhang, Chuanxin Huang, Ai-Bin Liang, Kai-Wei Liang, Hao Zhang, Jian-Feng Chen, Dachuan Zhang, Yi Zhong, Qi-Fa Liu, Guo-Qiang Chen, Cai-Wen Duan
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An E3 ligase and autophagy adaptor regulates tau proteostasis through nested phase separation Nat. Cell Biol. (IF 17.3) Pub Date : 2024-07-19
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A group 3 medulloblastoma stem cell program is maintained by OTX2-mediated alternative splicing Nat. Cell Biol. (IF 17.3) Pub Date : 2024-07-18 Olivier Saulnier, Jamie Zagozewski, Lisa Liang, Liam D. Hendrikse, Paul Layug, Victor Gordon, Kimberly A. Aldinger, Parthiv Haldipur, Stephanie Borlase, Ludivine Coudière-Morrison, Ting Cai, Emma Martell, Naomi M. Gonzales, Gareth Palidwor, Christopher J. Porter, Stéphane Richard, Tanveer Sharif, Kathleen J. Millen, Brad W. Doble, Michael D. Taylor, Tamra E. Werbowetski-Ogilvie
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The autophagy adaptor TRIAD3A promotes tau fibrillation by nested phase separation Nat. Cell Biol. (IF 17.3) Pub Date : 2024-07-15 Jiechao Zhou, Yang ‘an Chuang, Javier Redding-Ochoa, Rongzhen Zhang, Alexander J. Platero, Alexander H. Barrett, Juan C. Troncoso, Paul F. Worley, Wenchi Zhang
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Zeb1 mediates EMT/plasticity-associated ferroptosis sensitivity in cancer cells by regulating lipogenic enzyme expression and phospholipid composition Nat. Cell Biol. (IF 17.3) Pub Date : 2024-07-15 Annemarie Schwab, Zhigang Rao, Jie Zhang, André Gollowitzer, Katharina Siebenkäs, Nino Bindel, Elisabetta D’Avanzo, Ruthger van Roey, Yussuf Hajjaj, Ece Özel, Isabell Armstark, Leonhard Bereuter, Fengting Su, Julia Grander, Ehsan Bonyadi Rad, Arwin Groenewoud, Felix B. Engel, George W. Bell, Whitney S. Henry, José Pedro Friedmann Angeli, Marc P. Stemmler, Simone Brabletz, Andreas Koeberle, Thomas Brabletz
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Full-length GSDME mediates pyroptosis independent from cleavage Nat. Cell Biol. (IF 17.3) Pub Date : 2024-07-12 Bo Zhou, Zhi-hong Jiang, Meng-ran Dai, Yuan-li Ai, Li Xiao, Chuan-qi Zhong, Liu-Zheng Wu, Qi-tao Chen, Hang-zi Chen, Qiao Wu
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Pressure sensing of lysosomes enables control of TFEB responses in macrophages Nat. Cell Biol. (IF 17.3) Pub Date : 2024-07-12 Ruiqi Cai, Ori Scott, Gang Ye, Trieu Le, Ekambir Saran, Whijin Kwon, Subothan Inpanathan, Blayne A. Sayed, Roberto J. Botelho, Amra Saric, Stefan Uderhardt, Spencer A. Freeman
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Neutrophil-derived migrasomes are an essential part of the coagulation system Nat. Cell Biol. (IF 17.3) Pub Date : 2024-07-12 Dong Jiang, Lin Jiao, Qing Li, Renxiang Xie, Haohao Jia, ShiHui Wang, Yining Chen, Siyuan Liu, Dandan Huang, Jiajia Zheng, Wenhao Song, Ying Li, JianFeng Chen, Jinsong Li, Binwu Ying, Li Yu
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RNA scaffolds the Golgi ribbon by forming condensates with GM130 Nat. Cell Biol. (IF 17.3) Pub Date : 2024-07-11 Yijun Zhang, Joachim Seemann
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Mapping the chromatin accessibility landscape of zebrafish embryogenesis at single-cell resolution by SPATAC-seq Nat. Cell Biol. (IF 17.3) Pub Date : 2024-07-08 Keyong Sun, Xin Liu, Runda Xu, Chang Liu, Anming Meng, Xun Lan
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A single-cell atlas of chromatin accessibility in mouse organogenesis Nat. Cell Biol. (IF 17.3) Pub Date : 2024-07-08 Keyong Sun, Xin Liu, Xun Lan
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An organelle tango controls lipid metabolism Nat. Cell Biol. (IF 17.3) Pub Date : 2024-07-05 Johannes Pilic, Tatjana Kleele
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An activity-specificity trade-off encoded in human transcription factors Nat. Cell Biol. (IF 17.3) Pub Date : 2024-07-05 Julian Naderi, Alexandre P. Magalhaes, Gözde Kibar, Gregoire Stik, Yaotian Zhang, Sebastian D. Mackowiak, Hannah M. Wieler, Francesca Rossi, Rene Buschow, Marie Christou-Kent, Marc Alcoverro-Bertran, Thomas Graf, Martin Vingron, Denes Hnisz
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Functional multi-organelle units control inflammatory lipid metabolism of macrophages Nat. Cell Biol. (IF 17.3) Pub Date : 2024-07-05 Julia A. Zimmermann, Kerstin Lucht, Manuel Stecher, Chahat Badhan, Katharina M. Glaser, Maximilian W. Epple, Lena R. Koch, Ward Deboutte, Thomas Manke, Klaus Ebnet, Frauke Brinkmann, Olesja Fehler, Thomas Vogl, Ev-Marie Schuster, Anna Bremser, Joerg M. Buescher, Angelika S. Rambold
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Direct observation of translational activation by a ribonucleoprotein granule Nat. Cell Biol. (IF 17.3) Pub Date : 2024-07-04 Ruoyu Chen, William Stainier, Jeremy Dufourt, Mounia Lagha, Ruth Lehmann