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Lipid droplet-associated lncRNA LIPTER preserves cardiac lipid metabolism Nat. Cell Biol. (IF 28.213) Pub Date : 2023-06-01 Lei Han, Dayang Huang, Shiyong Wu, Sheng Liu, Cheng Wang, Yi Sheng, Xiongbin Lu, Hal E. Broxmeyer, Jun Wan, Lei Yang
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A people-centric approach to pursuing scientific discovery Nat. Cell Biol. (IF 28.213) Pub Date : 2023-05-30 Melina Casadio
Chun-Yan Lim is a group leader at the Guangzhou Laboratory, China, studying organelle contacts as metabolic signaling hubs. We reached out to Chun-Yan to discuss his scientific career and life in the lab.
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Host protection by two memory-like MAIT subsets Nat. Cell Biol. (IF 28.213) Pub Date : 2023-05-25 Margarita Dominguez-Villar
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Autophagy enables microglia to engage amyloid plaques and prevents microglial senescence Nat. Cell Biol. (IF 28.213) Pub Date : 2023-05-25 Insup Choi, Minghui Wang, Seungyeul Yoo, Peng Xu, Steven P. Seegobin, Xianting Li, Xian Han, Qian Wang, Junmin Peng, Bin Zhang, Zhenyu Yue
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Divergent metabolic programmes control two populations of MAIT cells that protect the lung Nat. Cell Biol. (IF 28.213) Pub Date : 2023-05-25 Thomas Riffelmacher, Mallory Paynich Murray, Chantal Wientjens, Shilpi Chandra, Viankail Cedillo-Castelán, Ting-Fang Chou, Sara McArdle, Christopher Dillingham, Jordan Devereaux, Aaron Nilsen, Simon Brunel, David M. Lewinsohn, Jeff Hasty, Gregory Seumois, Christopher A. Benedict, Pandurangan Vijayanand, Mitchell Kronenberg
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B cell senescence takes guts Nat. Cell Biol. (IF 28.213) Pub Date : 2023-05-24 Bennett G. Childs, Sara I. Graves, Darren J. Baker
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Mitoprotease LONP1 controls white-to-beige adipocyte conversion via metabolic enzyme turnover Nat. Cell Biol. (IF 28.213) Pub Date : 2023-05-24
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Proteolytic rewiring of mitochondria by LONP1 directs cell identity switching of adipocytes Nat. Cell Biol. (IF 28.213) Pub Date : 2023-05-22 Tingting Fu, Wanping Sun, Jiachen Xue, Zheng Zhou, Wen Wang, Qiqi Guo, Xinyi Chen, Danxia Zhou, Zhisheng Xu, Lin Liu, Liwei Xiao, Yan Mao, Likun Yang, Yujing Yin, Xue-Na Zhang, Qiangyou Wan, Bin Lu, Yuncong Chen, Min-Sheng Zhu, Philipp E. Scherer, Lei Fang, Hai-Long Piao, Mengle Shao, Zhenji Gan
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Single-nucleus multi-omics of human stem cell-derived islets identifies deficiencies in lineage specification Nat. Cell Biol. (IF 28.213) Pub Date : 2023-05-15 Punn Augsornworawat, Nathaniel J. Hogrebe, Matthew Ishahak, Mason D. Schmidt, Erica Marquez, Marlie M. Maestas, Daniel A. Veronese-Paniagua, Sarah E. Gale, Julia R. Miller, Leonardo Velazco-Cruz, Jeffrey R. Millman
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PBRM1 loss redirects chromatin remodelling complex to recruit oncogenic factors Nat. Cell Biol. (IF 28.213) Pub Date : 2023-05-11
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Bacterial induction of B cell senescence promotes age-related changes in the gut microbiota Nat. Cell Biol. (IF 28.213) Pub Date : 2023-05-11 Shimpei Kawamoto, Ken Uemura, Nozomi Hori, Lena Takayasu, Yusuke Konishi, Kazutaka Katoh, Tomonori Matsumoto, Masae Suzuki, Yusuke Sakai, Tatsuyuki Matsudaira, Takahiro Adachi, Naoko Ohtani, Daron M. Standley, Wataru Suda, Shinji Fukuda, Eiji Hara
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Tailoring 3′ UTRs alters metastatic potential Nat. Cell Biol. (IF 28.213) Pub Date : 2023-05-08 Kathleen Watt, Lynne-Marie Postovit
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Nonmetabolic role for CKB in ferroptosis Nat. Cell Biol. (IF 28.213) Pub Date : 2023-05-08 Eikan Mishima, Marcus Conrad
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An mRNA processing pathway suppresses metastasis by governing translational control from the nucleus Nat. Cell Biol. (IF 28.213) Pub Date : 2023-05-08 Albertas Navickas, Hosseinali Asgharian, Juliane Winkler, Lisa Fish, Kristle Garcia, Daniel Markett, Martin Dodel, Bruce Culbertson, Sohit Miglani, Tanvi Joshi, Keyi Yin, Phi Nguyen, Steven Zhang, Nicholas Stevers, Hun-Way Hwang, Faraz Mardakheh, Andrei Goga, Hani Goodarzi
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Creatine kinase B suppresses ferroptosis by phosphorylating GPX4 through a moonlighting function Nat. Cell Biol. (IF 28.213) Pub Date : 2023-05-08 Ke Wu, Meisi Yan, Tong Liu, Zheng Wang, Yuran Duan, Yan Xia, Guimei Ji, Yuli Shen, Lei Wang, Lin Li, Peixiang Zheng, Bofei Dong, Qingang Wu, Liwei Xiao, Xueying Yang, Haochen Shen, Ting Wen, Jingjing Zhang, Jinfeng Yi, Yuhan Deng, Xu Qian, Leina Ma, Jing Fang, Qin Zhou, Zhimin Lu, Daqian Xu
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ERADication of STING limits inflammation Nat. Cell Biol. (IF 28.213) Pub Date : 2023-05-04 Kevin MingJie Gao, Katherine A. Fitzgerald
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Endoplasmic reticulum-associated degradation shown to regulate innate immunity Nat. Cell Biol. (IF 28.213) Pub Date : 2023-05-04
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SEL1L–HRD1 endoplasmic reticulum-associated degradation controls STING-mediated innate immunity by limiting the size of the activable STING pool Nat. Cell Biol. (IF 28.213) Pub Date : 2023-05-04 Yewei Ji, Yuan Luo, Yating Wu, Yao Sun, Lianfeng Zhao, Zhen Xue, Mengqi Sun, Xiaoqiong Wei, Zinan He, Shuangcheng Alivia Wu, Liangguang Leo Lin, You Lu, Lei Chang, Fei Chen, Siyu Chen, Wei Qian, Xiaoxi Xu, Shengnuo Chen, Dongli Pan, Zhangsen Zhou, Sheng Xia, Chih-Chi Andrew Hu, Tingbo Liang, Ling Qi
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Mediterranean mechanisms of longevity Nat. Cell Biol. (IF 28.213) Pub Date : 2023-05-01 Alexander Richard Mendenhall
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Epigenetic programming defines haematopoietic stem cell fate restriction Nat. Cell Biol. (IF 28.213) Pub Date : 2023-05-01 Yiran Meng, Joana Carrelha, Roy Drissen, Xiying Ren, Bowen Zhang, Adriana Gambardella, Simona Valletta, Supat Thongjuea, Sten Eirik Jacobsen, Claus Nerlov
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Lipid droplets and peroxisomes are co-regulated to drive lifespan extension in response to mono-unsaturated fatty acids Nat. Cell Biol. (IF 28.213) Pub Date : 2023-05-01 Katharina Papsdorf, Jason W. Miklas, Amir Hosseini, Matias Cabruja, Christopher S. Morrow, Marzia Savini, Yong Yu, Carlos G. Silva-García, Nicole R. Haseley, Luke Meraz Murphy, Pallas Yao, Elisa de Launoit, Scott J. Dixon, Michael P. Snyder, Meng C. Wang, William B. Mair, Anne Brunet
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A guide from the stomach to β cells Nat. Cell Biol. (IF 28.213) Pub Date : 2023-04-27 Jinhyuk Choi, Fritz Cayabyab, Eiji Yoshihara
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Stomach-derived human insulin-secreting organoids restore glucose homeostasis Nat. Cell Biol. (IF 28.213) Pub Date : 2023-04-27 Xiaofeng Huang, Wei Gu, Jiaoyue Zhang, Ying Lan, Jonathan L. Colarusso, Sanlan Li, Christoph Pertl, Jiaqi Lu, Hyunkee Kim, Jian Zhu, David T. Breault, Jean Sévigny, Qiao Zhou
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Esrrb guides naive pluripotent cells through the formative transcriptional programme Nat. Cell Biol. (IF 28.213) Pub Date : 2023-04-27 Elena Carbognin, Valentina Carlini, Francesco Panariello, Martina Chieregato, Elena Guerzoni, Davide Benvegnù, Valentina Perrera, Cristina Malucelli, Marcella Cesana, Antonio Grimaldi, Margherita Mutarelli, Annamaria Carissimo, Eitan Tannenbaum, Hillel Kugler, Jamie A. Hackett, Davide Cacchiarelli, Graziano Martello
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Scientists with intersecting privilege must work towards institutional inclusion Nat. Cell Biol. (IF 28.213) Pub Date : 2023-04-25 Felicity M. Davis, Salah Elias, Vaishnavi Ananthanarayanan
The enduring lack of diversity, equity and inclusion (DEI) in academia is arguably the biggest challenge facing universities. Progress has been slow and dependent on the efforts of marginalized faculty. We explain why this is a problem, offer potential solutions and ask those with intersecting privilege and power to be the drivers of change.
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PBRM1-deficient PBAF complexes target aberrant genomic loci to activate the NF-κB pathway in clear cell renal cell carcinoma Nat. Cell Biol. (IF 28.213) Pub Date : 2023-04-24 Xiaosai Yao, Jing Han Hong, Amrita M. Nargund, Michelle Shu Wen Ng, Hong Lee Heng, Zhimei Li, Peiyong Guan, Masahiro Sugiura, Pek Lim Chu, Loo Chien Wang, Xiaofen Ye, James Qu, Xiu Yi Kwek, Jeffrey Chun Tatt Lim, Wen Fong Ooi, Joanna Koh, Zhenxun Wang, You-Fu Pan, Yan Shan Ong, Kiat-Yi Tan, Jian Yuan Goh, Sheng Rong Ng, Luca Pignata, Dachuan Huang, Alexander Lezhava, Su Ting Tay, Minghui Lee, Xun Hui
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Distal memory in wound healing and cancer Nat. Cell Biol. (IF 28.213) Pub Date : 2023-04-20 Frank Lyko
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A shared fate for nuclear and cytosolic inclusions Nat. Cell Biol. (IF 28.213) Pub Date : 2023-04-20 Simon Alberti, Serena Carra
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Tissue memory relies on stem cell priming in distal undamaged areas Nat. Cell Biol. (IF 28.213) Pub Date : 2023-04-20 Chiara Levra Levron, Mika Watanabe, Valentina Proserpio, Gabriele Piacenti, Andrea Lauria, Stefan Kaltenbach, Annalaura Tamburrini, Takuma Nohara, Francesca Anselmi, Carlotta Duval, Luca Elettrico, Daniela Donna, Laura Conti, Denis Baev, Ken Natsuga, Tzachi Hagai, Salvatore Oliviero, Giacomo Donati
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Nuclear and cytoplasmic spatial protein quality control is coordinated by nuclear–vacuolar junctions and perinuclear ESCRT Nat. Cell Biol. (IF 28.213) Pub Date : 2023-04-20 Emily M. Sontag, Fabián Morales-Polanco, Jian-Hua Chen, Gerry McDermott, Patrick T. Dolan, Daniel Gestaut, Mark A. Le Gros, Carolyn Larabell, Judith Frydman
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Specialized septins Nat. Cell Biol. (IF 28.213) Pub Date : 2023-04-14 Daryl J. V. David
Septins are conserved proteins that form heteromeric filaments of varied composition and have diverse roles, though it is unclear how specific septins have distinct functions. Cannon et al. report that a gene duplication of a septin results in similar but distinct septins with separate properties and functions.
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Iron regulation in ferroptosis Nat. Cell Biol. (IF 28.213) Pub Date : 2023-04-14 Zhe Wang
NRF2 is a transcription factor that confers resistance to oxidative stress and ferroptosis, a type of cell death that is mediated by free iron and lipid peroxidation. Here, Zhang and colleagues demonstrate that NRF2 modulates iron levels to dictate ferroptosis sensitivity.
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A new cell in an old tactile sensory organ Nat. Cell Biol. (IF 28.213) Pub Date : 2023-04-14 Ruijun Zhu, Yuh Nung Jan
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Arg-tRNA synthetase links inflammatory metabolism to RNA splicing and nuclear trafficking via SRRM2 Nat. Cell Biol. (IF 28.213) Pub Date : 2023-04-14 Haissi Cui, Jolene K. Diedrich, Douglas C. Wu, Justin J. Lim, Ryan M. Nottingham, James J. Moresco, John R. Yates, Benjamin J. Blencowe, Alan M. Lambowitz, Paul Schimmel
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TBC1D15 drives regeneration of acutely damaged lysosomes Nat. Cell Biol. (IF 28.213) Pub Date : 2023-04-12
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Genome-wide CRISPR screens identify ILF3 as a mediator of mTORC1-dependent amino acid sensing Nat. Cell Biol. (IF 28.213) Pub Date : 2023-04-10 Guokai Yan, Jinxin Yang, Wen Li, Ao Guo, Jialiang Guan, Ying Liu
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A twist to splicing regulation in haematopoiesis Nat. Cell Biol. (IF 28.213) Pub Date : 2023-04-06 Maria Carmo-Fonseca
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A lysosome membrane regeneration pathway depends on TBC1D15 and autophagic lysosomal reformation proteins Nat. Cell Biol. (IF 28.213) Pub Date : 2023-04-06 Anshu Bhattacharya, Rukmini Mukherjee, Santosh Kumar Kuncha, Melinda Elaine Brunstein, Rajeshwari Rathore, Stephan Junek, Christian Münch, Ivan Dikic
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DNMT3A-coordinated splicing governs the stem state switch towards differentiation in embryonic and haematopoietic stem cells Nat. Cell Biol. (IF 28.213) Pub Date : 2023-04-06 Raghav Ramabadran, Jarey H. Wang, Jaime M. Reyes, Anna G. Guzman, Sinjini Gupta, Carina Rosas, Lorenzo Brunetti, Michael C. Gundry, Ayala Tovy, Hali Long, Tianpeng Gu, Sean M. Cullen, Siddhartha Tyagi, Danielle Rux, Jean J. Kim, Steven M. Kornblau, Michael Kyba, Fabio Stossi, Rachel E. Rau, Koichi Takahashi, Thomas F. Westbrook, Margaret A. Goodell
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Dynamic antagonism between key repressive pathways maintains the placental epigenome Nat. Cell Biol. (IF 28.213) Pub Date : 2023-04-06 Raha Weigert, Sara Hetzel, Nina Bailly, Chuck Haggerty, Ibrahim A. Ilik, Philip Yuk Kwong Yung, Carmen Navarro, Adriano Bolondi, Abhishek Sampath Kumar, Chiara Anania, Björn Brändl, David Meierhofer, Darío G. Lupiáñez, Franz-Josef Müller, Tugce Aktas, Simon J. Elsässer, Helene Kretzmer, Zachary D. Smith, Alexander Meissner
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Author Correction: Tissue mechanics promote IDH1-dependent HIF1α–tenascin C feedback to regulate glioblastoma aggression Nat. Cell Biol. (IF 28.213) Pub Date : 2023-04-04 Yekaterina A. Miroshnikova, Janna K. Mouw, J. Matthew Barnes, Michael W. Pickup, Johnathan N. Lakins, Youngmi Kim, Khadjia Lobo, Anders I. Persson, Gerald F. Reis, Tracy R. McKnight, Eric C. Holland, Joanna J. Phillips, Valerie M. Weaver
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Metaboverse enables automated discovery and visualization of diverse metabolic regulatory patterns Nat. Cell Biol. (IF 28.213) Pub Date : 2023-04-03 Jordan A. Berg, Youjia Zhou, Yeyun Ouyang, Ahmad A. Cluntun, T. Cameron Waller, Megan E. Conway, Sara M. Nowinski, Tyler Van Ry, Ian George, James E. Cox, Bei Wang, Jared Rutter
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Basal stem cell progeny establish their apical surface in a junctional niche during turnover of an adult barrier epithelium Nat. Cell Biol. (IF 28.213) Pub Date : 2023-03-30 Anthony Galenza, Paola Moreno-Roman, Yu-Han Su, Lehi Acosta-Alvarez, Alain Debec, Antoine Guichet, Jon-Michael Knapp, Caroline Kizilyaprak, Bruno M. Humbel, Irina Kolotuev, Lucy Erin O’Brien
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Frontiers in biomolecular condensate research Nat. Cell Biol. (IF 28.213) Pub Date : 2023-03-27 Christine Mayr, Tanja Mittag, T.-Y. Dora Tang, Wenyu Wen, Hong Zhang, Huaiying Zhang
Biomolecular condensation of macromolecules is an increasingly important concept in cell biology. Indeed, research on condensates touches on multiple areas of research, from biochemistry to biophysics and from organelles to cell polarity. We asked experts at the forefront of this field to comment on what excites them most regarding biomolecular condensation, as well as on current challenges, priorities
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Perturbations in beta-cell heterogeneity in the pathogenesis of type 2 diabetes Nat. Cell Biol. (IF 28.213) Pub Date : 2023-03-27
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Co-option of epidermal cells enables touch sensing Nat. Cell Biol. (IF 28.213) Pub Date : 2023-03-23 Federica Mangione, Joshua Titlow, Catherine Maclachlan, Michel Gho, Ilan Davis, Lucy Collinson, Nicolas Tapon
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Single-cell and spatial transcriptomics during human organogenesis Nat. Cell Biol. (IF 28.213) Pub Date : 2023-03-22
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A beta cell subset with enhanced insulin secretion and glucose metabolism is reduced in type 2 diabetes Nat. Cell Biol. (IF 28.213) Pub Date : 2023-03-16 Alfonso Rubio-Navarro, Nicolás Gómez-Banoy, Lisa Stoll, Friederike Dündar, Alex M. Mawla, Lunkun Ma, Eric Cortada, Paul Zumbo, Ang Li, Moritz Reiterer, Nathalia Montoya-Oviedo, Edwin A. Homan, Norihiro Imai, Ankit Gilani, Chengyang Liu, Ali Naji, Boris Yang, Angie Chi Nok Chong, David E. Cohen, Shuibing Chen, Jingli Cao, Geoffrey S. Pitt, Mark O. Huising, Doron Betel, James C. Lo
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A single-cell transcriptome atlas profiles early organogenesis in human embryos Nat. Cell Biol. (IF 28.213) Pub Date : 2023-03-16 Yichi Xu, Tengjiao Zhang, Qin Zhou, Mengzhu Hu, Yao Qi, Yifang Xue, Yuxiao Nie, Lihui Wang, Zhirong Bao, Weiyang Shi
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Regulating enhancer activation Nat. Cell Biol. (IF 28.213) Pub Date : 2023-03-14 Sabrya Carim
Enhancer activation is generally accompanied by a reduction in DNA methylation (5-methylcytosine, 5mC) during mammalian development, but whether DNA demethylation regulates enhancer activity is unclear.
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Tackling neurodegeneration Nat. Cell Biol. (IF 28.213) Pub Date : 2023-03-14 Stylianos Lefkopoulos
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with diverse genetic etiologies. Pathology resulting from the DNA- and RNA-binding protein TDP-43 has been observed in neurodegenerative diseases, including ALS, frontotemporal dementia, Alzheimer’s disease and others. Linares et al. show that suppression of the pre-mRNA splicing factor SYF2 ameliorates neurodegeneration in ALS by improving
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Deadly actin collapse by disulfidptosis Nat. Cell Biol. (IF 28.213) Pub Date : 2023-03-14 Laura M. Machesky
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STING is ESCRTed to degradation by microautophagy Nat. Cell Biol. (IF 28.213) Pub Date : 2023-03-13 Sonia Assil, Søren R. Paludan
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Linking SARS-CoV-2 to the circadian clock Nat. Cell Biol. (IF 28.213) Pub Date : 2023-03-13 Soumita Das
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A multi-organoid platform identifies CIART as a key factor for SARS-CoV-2 infection Nat. Cell Biol. (IF 28.213) Pub Date : 2023-03-13 Xuming Tang, Dongxiang Xue, Tuo Zhang, Benjamin E. Nilsson-Payant, Lucia Carrau, Xiaohua Duan, Miriam Gordillo, Adrian Y. Tan, Yunping Qiu, Jenny Xiang, Robert E. Schwartz, Benjamin R. tenOever, Todd Evans, Shuibing Chen
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STING signalling is terminated through ESCRT-dependent microautophagy of vesicles originating from recycling endosomes Nat. Cell Biol. (IF 28.213) Pub Date : 2023-03-13 Yoshihiko Kuchitsu, Kojiro Mukai, Rei Uematsu, Yuki Takaada, Ayumi Shinojima, Ruri Shindo, Tsumugi Shoji, Shiori Hamano, Emari Ogawa, Ryota Sato, Kensuke Miyake, Akihisa Kato, Yasushi Kawaguchi, Masahiko Nishitani-Isa, Kazushi Izawa, Ryuta Nishikomori, Takahiro Yasumi, Takehiro Suzuki, Naoshi Dohmae, Takefumi Uemura, Glen N. Barber, Hiroyuki Arai, Satoshi Waguri, Tomohiko Taguchi
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SARS-CoV-2 causes DNA damage, cellular senescence and inflammation Nat. Cell Biol. (IF 28.213) Pub Date : 2023-03-09
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SARS-CoV-2 infection induces DNA damage, through CHK1 degradation and impaired 53BP1 recruitment, and cellular senescence Nat. Cell Biol. (IF 28.213) Pub Date : 2023-03-09 Ubaldo Gioia, Sara Tavella, Pamela Martínez-Orellana, Giada Cicio, Andrea Colliva, Marta Ceccon, Matteo Cabrini, Ana C. Henriques, Valeria Fumagalli, Alessia Paldino, Ettore Presot, Sreejith Rajasekharan, Nicola Iacomino, Federica Pisati, Valentina Matti, Sara Sepe, Matilde I. Conte, Sara Barozzi, Zeno Lavagnino, Tea Carletti, Maria Concetta Volpe, Paola Cavalcante, Matteo Iannacone, Chiara Rampazzo
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An inclusive and collaborative spirit for global progress in genomics Nat. Cell Biol. (IF 28.213) Pub Date : 2023-03-02 Melina Casadio
Dimple Notani is principal investigator (PI) at the National Centre for Biological Sciences (NCBS) in Bangalore, India, studying gene regulation. Nature Cell Biology contacted Dimple to discuss the state of the field and her experience running a research lab in India through a pandemic and as a junior PI.