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Deficiency of metabolic regulator PKM2 activates the pentose phosphate pathway and generates TCF1+ progenitor CD8+ T cells to improve immunotherapy Nat. Immunol. (IF 27.7) Pub Date : 2024-09-26 Geoffrey J. Markowitz, Yi Ban, Diamile A. Tavarez, Liron Yoffe, Enrique Podaza, Yongfeng He, Mitchell T. Martin, Michael J. P. Crowley, Tito A. Sandoval, Dingcheng Gao, M. Laura Martin, Olivier Elemento, Juan R. Cubillos-Ruiz, Timothy E. McGraw, Nasser K. Altorki, Vivek Mittal
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Recreating immune and epithelial interactions in organoids Nat. Immunol. (IF 27.7) Pub Date : 2024-09-25 Kevin Man, Axel Kallies
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An inhibitory PRR reels in the neutrophil response to NETs Nat. Rev. Immunol. (IF 67.7) Pub Date : 2024-09-24 Yvonne Bordon
MICL regulates neutrophil responses by serving as an inhibitory pattern-recognition receptor for NETs.
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Publisher Correction: Role of thymic stromal lymphopoietin in allergy and beyond Nat. Rev. Immunol. (IF 67.7) Pub Date : 2024-09-24 Risa Ebina-Shibuya, Warren J. Leonard
Correction to: Nature Reviews Immunology https://doi.org/10.1038/s41577-022-00735-y, published online 1 June 2022.
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Understanding vertebrate immunity through comparative immunology Nat. Rev. Immunol. (IF 67.7) Pub Date : 2024-09-24 Thomas Boehm
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Mitochondrial tonic for adoptive T cell therapies Nat. Rev. Immunol. (IF 67.7) Pub Date : 2024-09-20 Kirsty Minton
A study in Cell describes a platform to supply exogenous mitochondria to CD8+ T cells via nanotubes, which boosts their antitumour efficacy.
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IRF8 as durable architect of the microglial chromatin landscape Nat. Immunol. (IF 27.7) Pub Date : 2024-09-23 Maximilian Frosch, Marco Prinz
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IRF8 defines the epigenetic landscape in postnatal microglia, thereby directing their transcriptome programs Nat. Immunol. (IF 27.7) Pub Date : 2024-09-23 Keita Saeki, Richard Pan, Eunju Lee, Daisuke Kurotaki, Keiko Ozato
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Interleukin-34-orchestrated tumor-associated macrophage reprogramming is required for tumor immune escape driven by p53 inactivation Immunity (IF 25.5) Pub Date : 2024-09-24 Zhigang Nian, Yingchao Dou, Yiqing Shen, Jintang Liu, Xianghui Du, Yong Jiang, Yonggang Zhou, Binqing Fu, Rui Sun, Xiaohu Zheng, Zhigang Tian, Haiming Wei
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Multidimensional profiling of human T cells reveals high CD38 expression, marking recent thymic emigrants and age-related naive T cell remodeling Immunity (IF 25.5) Pub Date : 2024-09-24 Pavla Bohacova, Marina Terekhova, Petr Tsurinov, Riley Mullins, Kamila Husarcikova, Irina Shchukina, Alina Ulezko Antonova, Barbora Echalar, Jan Kossl, Adam Saidu, Thomas Francis, Chelsea Mannie, Laura Arthur, Stephen D.R. Harridge, Daniel Kreisel, Philip A. Mudd, Angela M. Taylor, Coleen A. McNamara, Marina Cella, Sidharth V. Puram, Maxim N. Artyomov
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Notch signaling regulates macrophage-mediated inflammation in metabolic dysfunction-associated steatotic liver disease Immunity (IF 25.5) Pub Date : 2024-09-23 Wei Guo, Ziyi Li, Gerasimos Anagnostopoulos, Wan Ting Kong, Shuangyan Zhang, Svetoslav Chakarov, Amanda Shin, Jiawen Qian, Yiwen Zhu, Wenjuan Bai, Olivier Cexus, Bin'en Nie, Jing Wang, Xiaoyu Hu, Camille Blériot, Zhaoyuan Liu, Baiyong Shen, Nicolas Venteclef, Bing Su, Florent Ginhoux
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Conversion of vaccines from low to high immunogenicity by antibodies with epitope complementarity Immunity (IF 25.5) Pub Date : 2024-09-20 Alexandra R. Dvorscek, Craig I. McKenzie, Vera C. Stäheli, Zhoujie Ding, Jacqueline White, Stewart A. Fabb, Leonard Lim, Kristy O’Donnell, Catherine Pitt, Daniel Christ, Danika L. Hill, Colin W. Pouton, Deborah L. Burnett, Robert Brink, Marcus J. Robinson, David M. Tarlinton, Isaak Quast
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Subset-specific mitochondrial stress and DNA damage shape T cell responses to fever and inflammation Sci. Immunol (IF 17.6) Pub Date : 2024-09-20 Darren R. Heintzman, Rachael C. Sinard, Emilie L. Fisher, Xiang Ye, Andrew R. Patterson, Joel H. Elasy, Kelsey Voss, Channing Chi, Ayaka Sugiura, Gabriel J. Rodriguez-Garcia, Nowrin U. Chowdhury, Emily N. Arner, Evan S. Krystoviak, Frank M. Mason, Yasmine T. Toudji, KayLee K. Steiner, Wasay Khan, Lana M. Olson, Angela L. Jones, Hanna S. Hong, Lindsay Bass, Katherine L. Beier, Wentao Deng, Costas A
Heat is a cardinal feature of inflammation, yet its impacts on immune cells remain uncertain. We show that moderate-grade fever temperatures (39°C) increased murine CD4 T cell metabolism, proliferation, and inflammatory effector activity while decreasing regulatory T cell suppressive capacity. However, heat-exposed T helper 1 (T H 1) cells selectively developed mitochondrial stress and DNA damage that
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Two-dose priming immunization amplifies humoral immunity by synchronizing vaccine delivery with the germinal center response Sci. Immunol (IF 17.6) Pub Date : 2024-09-20 Sachin H. Bhagchandani, Leerang Yang, Jonathan H. Lam, Laura Maiorino, Elana Ben-Akiva, Kristen A. Rodrigues, Anna Romanov, Heikyung Suh, Aereas Aung, Shengwei Wu, Anika Wadhera, Arup K. Chakraborty, Darrell J. Irvine
Prolonging exposure to subunit vaccines during the primary immune response enhances humoral immunity. Escalating-dose immunization (EDI), administering vaccines every other day in an increasing pattern over 2 weeks, is particularly effective but challenging to implement clinically. Here, using an HIV Env trimer/saponin adjuvant vaccine, we explored simplified EDI regimens and found that a two-shot
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Clinical and Molecular Analysis of Longitudinal Rhinitis Phenotypes in an Urban Birth Cohort. J. Allergy Clin. Immunol. (IF 11.4) Pub Date : 2024-09-20 Sima K Ramratnam,Molly Johnson,Cynthia M Visness,Agustin Calatroni,Mathew C Altman,Tomasz Janczyk,Kathryn E McCauley,Claire Schachtschneider,Kei E Fujimura,Douglas W Fadrosh,Susan V Lynch,Leonard B Bacharier,George T O'Connor,Megan T Sandel,Meyer Kattan,Robert A Wood,Peter J Gergen,Daniel J Jackson,Alkis Togias,James E Gern,
BACKGROUND Chronic rhinitis symptoms cause significant health burden among children and can have a heterogeneous presentation. Defining phenotypes of childhood chronic rhinitis and associated pathobiology may lead to prevention or improved treatments. OBJECTIVES To identify longitudinal patterns of rhinitis symptoms in childhood and determine their associations with early life risk factors, allergic
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Mucosal Trained-Immunity Based Vaccines: Cutting Recurrent Infections in Autoimmune Patients on Immunosuppression. J. Allergy Clin. Immunol. (IF 11.4) Pub Date : 2024-09-20 Gloria Candelas,Ángela Villegas,Silvia Sánchez-Ramón
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Beyond IL-5 inhibition for the treatment of episodic angioedema with eosinophilia (Gleich syndrome). J. Allergy Clin. Immunol. (IF 11.4) Pub Date : 2024-09-20 Emmanuel Ledoult,Matthieu Groh,Jean-Emmanuel Kahn,Guillaume Lefevre
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Mepolizumab for episodic angioedema with eosinophilia. J. Allergy Clin. Immunol. (IF 11.4) Pub Date : 2024-09-20 Matthew A Rank
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Sensing DNA as danger: The discovery of cGAS Immunity (IF 25.5) Pub Date : 2024-09-19 Richard A. Flavell, Esen Sefik
Insight into how the immune system recognizes and responds to pathogens had led to landmark advances in biology and medicine in the last decades. This year’s Albert Lasker Award for Basic Medical Research honors Zhijian “James” Chen for the discovery of cGAS, the enzyme that senses foreign and “pathogenic” self-DNA—self-DNA aberrantly located in intracellular compartments. The definition of the cGAS-STING
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Intestinal immunity in C. elegans is activated by pathogen effector-triggered aggregation of the guard protein TIR-1 on lysosome-related organelles Immunity (IF 25.5) Pub Date : 2024-09-18 Samantha Y. Tse-Kang, Khursheed A. Wani, Nicholas D. Peterson, Amanda Page, Fiachra Humphries, Read Pukkila-Worley
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Inducible antibacterial responses in macrophages Nat. Rev. Immunol. (IF 67.7) Pub Date : 2024-09-18 Matthew J. Sweet, Divya Ramnath, Amit Singhal, Ronan Kapetanovic
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Antigen presentation for central tolerance induction Nat. Rev. Immunol. (IF 67.7) Pub Date : 2024-09-18 Ludger Klein, Elisabetta Petrozziello
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Trained immunity-based vaccines for infections and allergic diseases. J. Allergy Clin. Immunol. (IF 11.4) Pub Date : 2024-09-18 Leticia Martín-Cruz,Cristina Benito-Villalvilla,Alba Angelina,José Luis Subiza,Oscar Palomares
Trained immunity has emerged as a new concept in immunology associated with the memory of innate immune cells and linked to specific metabolic and epigenetic reprogramming of these cells. Trained immunity may confer nonspecific and sustained protection against a broad range of pathogens, and recent findings show that it might also be involved in allergy mechanisms. Some conventional vaccines have demonstrated
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European Society of Immunodeficiencies guidelines for the management of patients with congenital athymia. J. Allergy Clin. Immunol. (IF 11.4) Pub Date : 2024-09-18 Alexandra Y Kreins,Fatima Dhalla,Aisling M Flinn,Evey Howley,Olov Ekwall,Anna Villa,Frank Jt Staal,Graham Anderson,Andrew R Gennery,Georg A Holländer,E Graham Davies,
Congenital athymia is a life-limiting disorder due to rare inborn errors of immunity causing impaired thymus organogenesis or abnormal thymic stromal cell development and function. Athymic infants have a T-B+NK+ immunophenotype with profound T lymphocyte deficiency and are susceptible to severe infections and autoimmunity. Patients variably display syndromic features. Expanding access to newborn screening
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Serum Cytokine Panels in Pediatric Clinical Practice. J. Allergy Clin. Immunol. (IF 11.4) Pub Date : 2024-09-18 Paul M Gallo,Jihwan Kim,Kevin O McNerney,Caroline Diorio,Caelin Foley,Laura Kagami,Kristina Wagner,Whitney L Petrosa,Hana Conlon,Kandace L Gollomp,Scott W Canna,Alix E Seif,Maire A Conrad,Judith R Kelsen,Neil Romberg,Hamid Bassiri,Kathleen E Sullivan,David T Teachey,Michele E Paessler,Edward M Behrens,Michele P Lambert
BACKGROUND Cytokines are soluble signaling proteins that regulate inflammation and coordinate immune responses. Serum cytokine assays are increasingly used in medical practice, yet our understanding of cytokines as biomarkers for disease remains limited. OBJECTIVES We aimed to analyze real-world single center usage of a multiplexed cytokine panel, correlate its results with diagnosis and severity,
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Striking a balance: new perspectives on homeostatic dendritic cell maturation Nat. Rev. Immunol. (IF 67.7) Pub Date : 2024-09-17 Victor Bosteels, Sophie Janssens
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Author Correction: Type I IFNs promote cancer cell stemness by triggering the epigenetic regulator KDM1B Nat. Immunol. (IF 27.7) Pub Date : 2024-09-17 Martina Musella, Andrea Guarracino, Nicoletta Manduca, Claudia Galassi, Eliana Ruggiero, Alessia Potenza, Ester Maccafeo, Gwenola Manic, Luca Mattiello, Sara Soliman Abdel Rehim, Michele Signore, Marco Pietrosanto, Manuela Helmer-Citterich, Matteo Pallocca, Maurizio Fanciulli, Tiziana Bruno, Francesca De Nicola, Giacomo Corleone, Anna Di Benedetto, Cristiana Ercolani, Edoardo Pescarmona, Laura Pizzuti
Correction to: Nature Immunology https://doi.org/10.1038/s41590-022-01290-3, published online 24 August 2022.
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A B cell receptor variant confers evolutionary protection against pathogens Nat. Immunol. (IF 27.7) Pub Date : 2024-09-17
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Genomic map of the cellular composition of the tumor microenvironment Nat. Immunol. (IF 27.7) Pub Date : 2024-09-17
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Epigenetic tuning of PD-1 expression improves exhausted T cell function and viral control Nat. Immunol. (IF 27.7) Pub Date : 2024-09-17 Sarah A. Weiss, Amy Y. Huang, Megan E. Fung, Daniela Martinez, Alex C. Y. Chen, Thomas J. LaSalle, Brian C. Miller, Christopher D. Scharer, Mudra Hegde, Thao H. Nguyen, Jared H. Rowe, Jossef F. Osborn, Dillon G. Patterson, Natalia Sifnugel, C. Mei-An Nolan, Richard A. Davidson, Marc A. Schwartz, Alexander P. R. Bally, Dennis K. Neeld, Martin W. LaFleur, Jeremy M. Boss, John G. Doench, W. Nicholas Haining
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Using art and history to communicate immunology to a broad audience Nat. Rev. Immunol. (IF 67.7) Pub Date : 2024-09-16 Francesca Di Rosa
Francesca Di Rosa works on T cells and is committed to science outreach. Together with Adrian Hayday, she recently conceptualized and delivered the exhibit ‘Vaccination, a time machine’ at the Royal Society Summer Exhibition in London. Here, she shares her thoughts on how to communicate a core scientific content with artistic and historical input, according to her ‘5C’ formula.
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Mast cell BH4–serotonin metabolic network implicated in postoperative pain Nat. Rev. Immunol. (IF 67.7) Pub Date : 2024-09-16 Alexandra Flemming
Starkl et al. show that mast cells have a key role in the metabolic network that underlies postoperative pain and demonstrate that this can be therapeutically targeted in mouse models.
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The complexity of immune evasion mechanisms throughout the metastatic cascade Nat. Immunol. (IF 27.7) Pub Date : 2024-09-16 Nicole M. Haynes, Thomas B. Chadwick, Belinda S. Parker
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Tumor-reactive T cell clonotype dynamics underlying clinical response to TIL therapy in melanoma Immunity (IF 25.5) Pub Date : 2024-09-13 Johanna Chiffelle, David Barras, Rémy Pétremand, Angela Orcurto, Sara Bobisse, Marion Arnaud, Aymeric Auger, Blanca Navarro Rodrigo, Eleonora Ghisoni, Christophe Sauvage, Damien Saugy, Alexandra Michel, Baptiste Murgues, Noémie Fahr, Martina Imbimbo, Maria Ochoa de Olza, Sofiya Latifyan, Isaac Crespo, Fabrizio Benedetti, Raphael Genolet, George Coukos
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CD4 + T cells with convergent TCR recombination reprogram stroma and halt tumor progression in adoptive therapy Sci. Immunol (IF 17.6) Pub Date : 2024-09-13 Steven P. Wolf, Matthias Leisegang, Madeline Steiner, Veronika Wallace, Kazuma Kiyotani, Yifei Hu, Leonie Rosenberger, Jun Huang, Karin Schreiber, Yusuke Nakamura, Andrea Schietinger, Hans Schreiber
Cancers eventually kill hosts even when infiltrated by cancer-specific T cells. We examined whether cancer-specific T cell receptors of CD4 + T cells (CD4TCRs) from tumor-bearing hosts can be exploited for adoptive TCR therapy. We focused on CD4TCRs targeting an autochthonous mutant neoantigen that is only presented by stroma surrounding the MHC class II–negative cancer cells. The 11 most common tetramer-sorted
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Expansion of tumor-reactive CD8 + T cell clonotypes occurs in the spleen in response to immune checkpoint blockade Sci. Immunol (IF 17.6) Pub Date : 2024-09-13 Duncan M. Morgan, Brendan L. Horton, Vidit Bhandarkar, Richard Van, Teresa Dinter, Maria Zagorulya, J. Christopher Love, Stefani Spranger
Immune checkpoint blockade (ICB) enhances T cell responses against cancer, leading to long-term survival in a fraction of patients. CD8 + T cell differentiation in response to chronic antigen stimulation is highly complex, and it remains unclear precisely which T cell differentiation states at which anatomic sites are critical for the response to ICB. We identified an intermediate-exhausted population
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Dual blockade of IL-10 and PD-1 leads to control of SIV viral rebound following analytical treatment interruption Nat. Immunol. (IF 27.7) Pub Date : 2024-09-12 Susan Pereira Ribeiro, Zachary Strongin, Hugo Soudeyns, Felipe ten-Caten, Khader Ghneim, Gabriela Pacheco Sanchez, Giuliana Xavier de Medeiros, Perla Mariana Del Rio Estrada, Adam-Nicolas Pelletier, Timothy Hoang, Kevin Nguyen, Justin Harper, Sherrie Jean, Chelsea Wallace, Robert Balderas, Jeffrey D. Lifson, Gopalan Raghunathan, Eric Rimmer, Cinthia Pastuskova, Guoxin Wu, Luca Micci, Ruy M. Ribeiro
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An IGHG1 variant exhibits polarized prevalence and confers enhanced IgG1 antibody responses against life-threatening organisms Nat. Immunol. (IF 27.7) Pub Date : 2024-09-11 Wenbo Sun, Tingyu Yang, Fengming Sun, Panhong Liu, Ji Gao, Xianmei Lan, Wei Xu, Yuhong Pang, Tong Li, Cuifeng Li, Qingtai Liang, Haoze Chen, Xiaohang Liu, Wenting Tan, Huanhuan Zhu, Fang Wang, Fanjun Cheng, Weiwei Zhai, Han-Na Kim, Jingren Zhang, Linqi Zhang, Lu Lu, Qiaoran Xi, Guohong Deng, Yanyi Huang, Xin Jin, Xiangjun Chen, Wanli Liu
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Determinants of Persistence and Recovery of Chronic COVID19 Chemosensory Dysfunction. J. Allergy Clin. Immunol. (IF 11.4) Pub Date : 2024-09-11 Dante G Minichetti,Amelia Boyd,Evan Lemire,Jonathan Hacker,Adam L Haber,Rachel E Roditi,Mark W Albers,Stella Lee,Kathleen M Buchheit,Tanya M Laidlaw,Lora G Bankova
BACKGROUND In 2-4% of patients, COVID19 chemosensory dysfunction (CSD) persists beyond six months, accounting for up to 4 million people in the US. The predictors of persistence and recovery require further exploration. OBJECTIVE To define the predictors of recovery and assess the quality of CSD in registry subjects with self-reported persistent smell and taste dysfunction after COVID19. METHODS COVID19
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Microbes and metabolites in immunity Immunity (IF 25.5) Pub Date : 2024-09-10 Eran Elinav, Suzanne Devkota, Marlies Meisel, Shu Zhu, Hiutung Chu, Haiwei Chen, Jens Puschhof, Florencia McAllister, Randall Jeffrey Platt, Kenya Honda
The immune system has a vital, albeit complex, relationship with the microbes residing within us, one that we are only beginning to understand. We asked investigators what they felt were the fundamental challenges we currently face in unraveling the impacts of microbes and their metabolites on host immunity and to discuss key opportunities toward achieving future insights and innovation.
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Microglia bridge brain activity and blood pressure Immunity (IF 25.5) Pub Date : 2024-09-10 Yanxia Rao, Bo Peng
Our brain is not an immune-privileged island isolated from peripheries, but how non-neuronal brain cells interact with the peripheral system is not well understood. Wei et al. report that microglia in the hypothalamic paraventricular nucleus (PVN) with unique vasculature can detect ATP derived from hemodynamic disturbance. These microglia in the PVN regulate the response to hypertension via ATP-P2Y12-C/EBPβ
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Neighbor’s feedback helps macrophages learn tolerance in the gut Immunity (IF 25.5) Pub Date : 2024-09-10 Giuseppe Giuliani, Jayajit Das
Intestinal macrophages play a key role in regulating immune tolerance in the gut. In this issue of Immunity, Mertens et al. uncover a mechanism for the establishment of memory in macrophage tolerance in the gut involving a bistable metabolic switch in macrophages and an intercellular positive feedback between macrophages and intestinal epithelial cells (IECs).
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An anti-aging vaccine: BCG turns back the clock on remyelination failure Immunity (IF 25.5) Pub Date : 2024-09-10 Janssen M. Kotah, Bart J.L. Eggen
Aging leads to alterations that precipitate or aggravate several diseases that occur across our lifespan. In the CNS, aging affects the capacity to maintain and repair the myelin sheaths that protect axons and facilitate neuronal signaling. Tiwari et al. report aging-associated transcriptional responses in microglia after demyelination, which could be reversed by epigenetic remodeling after BCG vaccination
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The epigenomic matrix of tissue-specific immune memory Immunity (IF 25.5) Pub Date : 2024-09-10 Sarah Adamo, Marcus Buggert
Tissue-resident memory CD8+ T cells serve as a first-line defense against many pathogens. In this issue of Immunity, Buquicchio et al. unveil the epigenomic landscapes of virus-specific CD8+ T cell subsets, highlighting common and organ-specific regulators driving their differentiation.
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The inflammaging clock strikes IL-11! Immunity (IF 25.5) Pub Date : 2024-09-10 Saad Khan, Veronica Chang, Daniel A. Winer
Chronic inflammation is considered a hallmark of aging. In a recent issue of Nature, Widjaja et al. examined genetic and pharmacologic inhibition of interleukin (IL)-11 on aging pathology and found that inhibiting IL-11 signaling increases lifespan and healthspan in mice.
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Publisher Correction: Immunological studies in trans-individuals undergoing gender affirming hormone therapy Nat. Rev. Immunol. (IF 67.7) Pub Date : 2024-09-10 Anna James, Petter Brodin
Correction to: Nature Reviews Immunology https://doi.org/10.1038/s41577-024-01070-0, published online 4 September 2024.
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Towards a unifying model for B-cell receptor triggering Nat. Rev. Immunol. (IF 67.7) Pub Date : 2024-09-10 Søren E. Degn, Pavel Tolar
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Tissue-specific inducible IL-33 expression elicits features of eosinophilic esophagitis. J. Allergy Clin. Immunol. (IF 11.4) Pub Date : 2024-09-10 Grace C Pyon,Mia Y Masuda,Arina Putikova,Huijun Luo,Jessica B Gibson,Adelyn D Dao,Danna R Ortiz,Piper L Heiligenstein,James J Bonellos,William E LeSuer,Rish K Pai,Shipra Garg,Matthew A Rank,Hiroshi Nakagawa,Hirohito Kita,Benjamin L Wright,Alfred D Doyle
BACKGROUND IL-33 is a type 2 inflammatory cytokine that is elevated in the esophageal epithelium of EoE subjects. We previously developed a mouse model of EoE dependent on constitutive overexpression of IL-33 from the esophageal epithelium (EoE33). OBJECTIVE Our objective was to develop an inducible, IL-33-dependent model of EoE and examine induction of EoE-associated pathology. METHODS We utilized
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NETs activate Notch- γ secretase signaling in hidradenitis suppurativa. J. Allergy Clin. Immunol. (IF 11.4) Pub Date : 2024-09-10 Christopher B Oliveira,Jorge Romo-Tena,Eduardo Patino-Martinez,Alexandra Woo,Angel S Byrd,Dongwon Kim,Ginette A Okoye,Mariana J Kaplan,Carmelo Carmona-Rivera
BACKGROUND Hidradenitis suppurativa (HS) is an inflammatory chronic skin disorder of unknown etiology characterized by inflamed abscess-like nodules and boils resulting in sinus tract formation, tissue scarring and massive infiltration of neutrophils. Multiple lines of evidence have highlighted the potential association between alterations in the Notch pathway and HS pathogenesis, but the mechanisms
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From genes to geography: Mapping allergic disease landscapes with spatial transcriptomics. J. Allergy Clin. Immunol. (IF 11.4) Pub Date : 2024-09-12 Sumanth Chennareddy,Patrick M Brunner
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Have a cake and eat it too: the importance of metaphors in research communication Nat. Rev. Immunol. (IF 67.7) Pub Date : 2024-09-09 Anne Spurkland
Anne Spurkland is a professor of medicine, and her research interests include T cell activation and autoimmunity. She is also an avid baker of cakes that everyone can have and eat too, irrespective of allergies and dietary preferences. This latter passion propelled her into national fame as one of Norway’s most visible experts on immunity and viruses during the COVID-19 pandemic.
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Inflammasome components as new therapeutic targets in inflammatory disease Nat. Rev. Immunol. (IF 67.7) Pub Date : 2024-09-09 Rebecca C. Coll, Kate Schroder
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Author Correction: Genetic variants in UNC93B1 predispose to childhood-onset systemic lupus erythematosus Nat. Immunol. (IF 27.7) Pub Date : 2024-09-09 Mahmoud Al-Azab, Elina Idiiatullina, Ziyang Liu, Meng Lin, Katja Hrovat-Schaale, Huifang Xian, Jianheng Zhu, Mandy Yang, Bingtai Lu, Zhiyao Zhao, Yiyi Liu, Jingjie Chang, Xiaotian Li, Caiqin Guo, Yunfeng Liu, Qi Wu, Jiazhang Chen, Chaoting Lan, Ping Zeng, Jun Cui, Xia Gao, Wenhao Zhou, Yan Zhang, Yuxia Zhang, Seth L. Masters
Correction to: Nature Immunology https://doi.org/10.1038/s41590-024-01846-5, published online 3 June 2024.
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A pinch of salt boosts T cell function Nat. Immunol. (IF 27.7) Pub Date : 2024-09-09 Karina L. Hajdu, Lorène Rousseau, Ping-Chih Ho
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CD45 threads the needle of cytokine cancer immunotherapy Nat. Immunol. (IF 27.7) Pub Date : 2024-09-09 Nils Wellhausen, Saar Gill
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The renaissance of oral tolerance: merging tradition and new insights Nat. Rev. Immunol. (IF 67.7) Pub Date : 2024-09-06 Vuk Cerovic, Oliver Pabst, Allan McI Mowat
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The promise and reality of new immune profiling technologies Nat. Immunol. (IF 27.7) Pub Date : 2024-09-06 Sara Suliman, David P. Maison, Timothy J. Henrich
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Pre-vax metabolic clues: Cracking the code to a better dengue vaccine. Sci. Immunol (IF 17.6) Pub Date : 2024-09-06 Fahima Akther,David R Martinez
Multi-omic analysis deciphers the impact of cell-intrinsic and systemic metabolomes on dengue vaccination immunogenicity.
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When a double negative is not a positive: Autoantibodies against IL-10 in patients with inflammatory bowel disease. Sci. Immunol (IF 17.6) Pub Date : 2024-09-06 Colleen M Noviello
IL-10 autoantibodies are detected in two patients with severe inflammatory bowel disease.
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IgE plasma cells are transcriptionally and functionally distinct from other isotypes Sci. Immunol (IF 17.6) Pub Date : 2024-09-06 Andrea Vecchione, Joseph C. Devlin, Carley Tasker, Venkat Raman Ramnarayan, Paul Haase, Eva Conde, Devin Srivastava, Gurinder S. Atwal, Pierre Bruhns, Andrew J. Murphy, Matthew A. Sleeman, Andre Limnander, Wei Keat Lim, Seblewongel Asrat, Jamie M. Orengo
Understanding the phenotypic and transcriptional signature of immunoglobulin E (IgE)–producing cells is fundamental to plasma cell (PC) biology and development of therapeutic interventions for allergy. Here, using a mouse model of intranasal house dust mite (HDM) exposure, we showed that short-lived IgE PCs emerge in lung draining lymph nodes (dLNs) during early exposure (<3 weeks) and long-lived IgE