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A method for predicting drugs that can boost the efficacy of immune checkpoint blockade Nat. Immunol. (IF 30.5) Pub Date : 2024-03-18 Yun Xia, Xin Li, Nana Bie, Wen Pan, Ya-Ru Miao, Mei Yang, Yan Gao, Chuang Chen, Hanqing Liu, Lu Gan, An-Yuan Guo
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Single-cell NAD(H) levels predict clonal lymphocyte expansion dynamics Sci. Immunol (IF 24.8) Pub Date : 2024-03-15 Lucien Turner, Tran Ngoc Van Le, Eric Cross, Clemence Queriault, Montana Knight, Krittin Trihemasava, James Davis, Patrick Schaefer, Janet Nguyen, Jimmy Xu, Brian Goldspiel, Elise Hall, Kelly Rome, Michael Scaglione, Joel Eggert, Byron Au-Yeung, Douglas C. Wallace, Clementina Mesaros, Joseph A. Baur, Will Bailis
Adaptive immunity requires the expansion of high-affinity lymphocytes from a heterogeneous pool. Whereas current models explain this through signal transduction, we hypothesized that antigen affinity tunes discrete metabolic pathways to license clonal lymphocyte dynamics. Here, we identify nicotinamide adenine dinucleotide (NAD) biosynthesis as a biochemical hub for the T cell receptor affinity–dependent
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A metabolic pacer ensures smooth running of the lymphocyte activation race Sci. Immunol (IF 24.8) Pub Date : 2024-03-15 Veera Panova, Arianne C. Richard
Upon lymphocyte stimulation, accumulation of intracellular NAD(H) reflects the strength of antigen receptor signals and controls the rate of cell cycle entry and proliferation (see related Research Article by Turner et al.).
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Bone marrow inflammation in haematological malignancies Nat. Rev. Immunol. (IF 100.3) Pub Date : 2024-03-15 Madelon M. E. de Jong, Lanpeng Chen, Marc H. G. P. Raaijmakers, Tom Cupedo
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Strategies for targeting cytokines in inflammatory bowel disease Nat. Rev. Immunol. (IF 100.3) Pub Date : 2024-03-14 Markus F. Neurath
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Anaphylactic degranulation by mast cells requires the mobilization of inflammasome components Nat. Immunol. (IF 30.5) Pub Date : 2024-03-14 Andrea Mencarelli, Pradeep Bist, Hae Woong Choi, Hanif Javanmard Khameneh, Alessandra Mortellaro, Soman N. Abraham
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Author Correction: The DExD/H-box helicase Dicer-2 mediates the induction of antiviral activity in drosophila Nat. Immunol. (IF 30.5) Pub Date : 2024-03-15 Safia Deddouche, Nicolas Matt, Aidan Budd, Stefanie Mueller, Cordula Kemp, Delphine Galiana-Arnoux, Catherine Dostert, Christophe Antoniewski, Jules A. Hoffmann, Jean-Luc Imler
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The power of memory T cells minus antibodies Nat. Immunol. (IF 30.5) Pub Date : 2024-03-15 Thi H. O. Nguyen, Katherine Kedzierska
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Gut bacteria–derived serotonin promotes immune tolerance in early life Sci. Immunol (IF 24.8) Pub Date : 2024-03-15 Katherine Z. Sanidad, Stephanie L. Rager, Hannah C. Carrow, Aparna Ananthanarayanan, Ryann Callaghan, Lucy R. Hart, Tingting Li, Purnima Ravisankar, Julia A. Brown, Mohammed Amir, Jenny C. Jin, Alexandria Rose Savage, Ryan Luo, Florencia Mardorsky Rowdo, M. Laura Martin, Randi B. Silver, Chun-Jun Guo, Jan Krumsiek, Naohiro Inohara, Melody Y. Zeng
The gut microbiota promotes immune system development in early life, but the interactions between the gut metabolome and immune cells in the neonatal gut remain largely undefined. Here, we demonstrate that the neonatal gut is uniquely enriched with neurotransmitters, including serotonin, and that specific gut bacteria directly produce serotonin while down-regulating monoamine oxidase A to limit serotonin
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A metabolic pacer ensures smooth running of the lymphocyte activation race Sci. Immunol (IF 24.8) Pub Date : 2024-03-15 Veera Panova, Arianne C. Richard
Upon lymphocyte stimulation, accumulation of intracellular NAD(H) reflects the strength of antigen receptor signals and controls the rate of cell cycle entry and proliferation (see related Research Article by Turner et al .).
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RORγt up-regulates RAG gene expression in DP thymocytes to expand the Tcra repertoire Sci. Immunol (IF 24.8) Pub Date : 2024-03-15 Abani Kanta Naik, Danielle J. Dauphars, Elizabeth Corbett, Lunden Simpson, David G. Schatz, Michael S. Krangel
Recombination activating gene (RAG) expression increases as thymocytes transition from the CD4 − CD8 − double-negative (DN) to the CD4 + CD8 + double-positive (DP) stage, but the physiological importance and mechanism of transcriptional up-regulation are unknown. Here, we show that a DP-specific component of the recombination activating genes antisilencer (DPASE) provokes elevated RAG expression in
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Single-cell NAD(H) levels predict clonal lymphocyte expansion dynamics Sci. Immunol (IF 24.8) Pub Date : 2024-03-15 Lucien Turner, Tran Ngoc Van Le, Eric Cross, Clemence Queriault, Montana Knight, Krittin Trihemasava, James Davis, Patrick Schaefer, Janet Nguyen, Jimmy Xu, Brian Goldspiel, Elise Hall, Kelly Rome, Michael Scaglione, Joel Eggert, Byron Au-Yeung, Douglas C. Wallace, Clementina Mesaros, Joseph A. Baur, Will Bailis
Adaptive immunity requires the expansion of high-affinity lymphocytes from a heterogeneous pool. Whereas current models explain this through signal transduction, we hypothesized that antigen affinity tunes discrete metabolic pathways to license clonal lymphocyte dynamics. Here, we identify nicotinamide adenine dinucleotide (NAD) biosynthesis as a biochemical hub for the T cell receptor affinity–dependent
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Pas de deux of NLRP3 and ASC with CD63 on mast cell granules Nat. Immunol. (IF 30.5) Pub Date : 2024-03-14 J. Magarian Blander, Yuhua Shi
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Antibody-independent protection against heterologous SARS-CoV-2 challenge conferred by prior infection or vaccination Nat. Immunol. (IF 30.5) Pub Date : 2024-03-14 Valeria Fumagalli, Micol Ravà, Davide Marotta, Pietro Di Lucia, Elisa B. Bono, Leonardo Giustini, Federica De Leo, Maura Casalgrandi, Emanuele Monteleone, Violette Mouro, Chiara Malpighi, Chiara Perucchini, Marta Grillo, Sara De Palma, Lorena Donnici, Silvia Marchese, Matteo Conti, Hiromi Muramatsu, Stanley Perlman, Norbert Pardi, Mirela Kuka, Raffaele De Francesco, Marco E. Bianchi, Luca G. Guidotti
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Immunological imprinting shapes the specificity of human antibody responses against SARS-CoV-2 variants Immunity (IF 32.4) Pub Date : 2024-03-14 Timothy S. Johnston, Shuk Hang Li, Mark M. Painter, Reilly K. Atkinson, Naomi R. Douek, David B. Reeg, Daniel C. Douek, E. John Wherry, Scott E. Hensley
The spike glycoprotein of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) continues to accumulate substitutions, leading to breakthrough infections of vaccinated individuals. It remains unclear if exposures to antigenically distant SARS-CoV-2 variants can overcome memory B cell biases established by initial SARS-CoV-2 encounters. We determined the specificity and functionality of antibody
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Persistent immune imprinting occurs after vaccination with the COVID-19 XBB.1.5 mRNA booster in humans Immunity (IF 32.4) Pub Date : 2024-03-14 M. Alejandra Tortorici, Amin Addetia, Albert J. Seo, Jack Brown, Kaiti Sprouse, Jenni Logue, Erica Clark, Nicholas Franko, Helen Chu, David Veesler
Immune imprinting describes how the first exposure to a virus shapes immunological outcomes of subsequent exposures to antigenically related strains. Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) Omicron breakthrough infections and bivalent COVID-19 vaccination primarily recall cross-reactive memory B cells induced by prior Wuhan-Hu-1 spike mRNA vaccination rather than priming Omicron-specific
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Breaking tolerance: the autoimmune aspect of atherosclerosis Nat. Rev. Immunol. (IF 100.3) Pub Date : 2024-03-12 Amir Khan, Payel Roy, Klaus Ley
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Regulation of innate-like activities of neonatal CD8+ T cells Nat. Rev. Immunol. (IF 100.3) Pub Date : 2024-03-11 Alexandra Flemming
Recent studies have shown that neonatal CD8+ T cells can undergo ‘bystander activation’ in response to inflammatory cytokines and produce effector molecules such as IFNγ and granzyme B in the absence of cognate antigen. Some of these cells persist into adulthood. A study by Watson et al. used a multi-omics approach to investigate the epigenetic programmes and transcription factors that enable CD8+
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The eye provides an immunological gateway to the brain Nat. Rev. Immunol. (IF 100.3) Pub Date : 2024-03-11 Alexandra Flemming
A publication by Song and colleagues identifies a unique lymphatic drainage system that connects the posterior of the eye with deep cervical lymph nodes (dCLNs) and the meningeal lymphatic network. In several different mouse models, they show that vaccines delivered to the posterior of the eye can specifically induce immune responses in the central nervous system (CNS) and protect against experimental
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CARD8 kills CD4+ T cells in response to HIV entry Nat. Rev. Immunol. (IF 100.3) Pub Date : 2024-03-11 Alexandra Flemming
In humans, infection with HIV-1 is associated with loss of CD4+ T cells, causing severe immunodeficiency and progression to AIDS. By contrast, some non-human primates (NHPs), which are natural hosts of the closely related SIV, are tolerant of SIV infection despite showing high levels of viraemia. Interestingly, CD4+ T cell death in humans mostly effects quiescent cells that are not productively infected
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Dual checkpoint T(h1)eamwork makes the anti-cancer dream work Immunity (IF 32.4) Pub Date : 2024-03-12 Alisa Dietl, Anna Ralser, Karin Pelka
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IL-4-ever young: Type 2 cytokine signaling in macrophages slows aging Immunity (IF 32.4) Pub Date : 2024-03-12 Conor M. Finlay, Judith E. Allen
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Predicting plasma cell retention and loss over a lifetime Immunity (IF 32.4) Pub Date : 2024-03-12 Marcus J. Robinson, David M. Tarlinton
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Gasdermin and MLKL necrotic cell death effectors: Signaling and diseases Immunity (IF 32.4) Pub Date : 2024-03-12 Kate E. Lawlor, James M. Murphy, James E. Vince
Diverse inflammatory conditions, from infections to autoimmune disease, are often associated with cellular damage and death. Apoptotic cell death has evolved to minimize its inflammatory potential. By contrast, necrotic cell death via necroptosis and pyroptosis—driven by membrane-damaging MLKL and gasdermins, respectively—can both initiate and propagate inflammatory responses. In this review, we provide
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Complement-ary protection for all ages Immunity (IF 32.4) Pub Date : 2024-03-12 Geongoo Han, Shipra Vaishnava
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The price of P2X7R freedom is neuroinflammation Immunity (IF 32.4) Pub Date : 2024-03-12 Mingqian Fang, Ren Lai
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Epstein-Barr virus gp42 antibodies reveal sites of vulnerability for receptor binding and fusion to B cells Immunity (IF 32.4) Pub Date : 2024-03-12 Wei Bu, Ashish Kumar, Nathan L. Board, JungHyun Kim, Kennichi Dowdell, Shu Zhang, Yona Lei, Anna Hostal, Tammy Krogmann, Yanmei Wang, Stefania Pittaluga, Joseph Marcotrigiano, Jeffrey I. Cohen
Epstein-Barr virus (EBV) causes infectious mononucleosis and is associated with B cell lymphomas. EBV glycoprotein 42 (gp42) binds HLA class II and activates membrane fusion with B cells. We isolated gp42-specific monoclonal antibodies (mAbs), A10 and 4C12, which use distinct mechanisms to neutralize virus infection. mAb A10 was more potent than the only known neutralizing gp42 mAb, F-2-1, in neutralizing
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Interleukin-2 signaling in the regulation of T cell biology in autoimmunity and cancer Immunity (IF 32.4) Pub Date : 2024-03-12 Acacia N. Shouse, Kathryn M. LaPorte, Thomas R. Malek
Interleukin-2 (IL-2) is a critical cytokine for T cell peripheral tolerance and immunity. Here, we review how IL-2 interaction with the high-affinity IL-2 receptor (IL-2R) supports the development and homeostasis of regulatory T cells and contributes to the differentiation of helper, cytotoxic, and memory T cells. A critical element for each T cell population is the expression of CD25 (Il2rα), which
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Made to order: emergency myelopoiesis and demand-adapted innate immune cell production Nat. Rev. Immunol. (IF 100.3) Pub Date : 2024-03-11 James W. Swann, Oakley C. Olson, Emmanuelle Passegué
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A Treg cell duo for VAT control Nat. Rev. Immunol. (IF 100.3) Pub Date : 2024-03-08 Maria Papatriantafyllou
Changes in populations of regulatory T (Treg) cells in visceral adipose tissue (VAT) have been linked to metabolic disorders; Valle Torres, Man et al. now characterize Treg cell heterogeneity in VAT. In addition to the previously reported population of VAT Treg cells that express PPARγ and ST2 (also known as IL-33R or IL-1RL1), the authors describe a second VAT Treg cell subset with high expression
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Lymph node resection does not impair cancer immunotherapy responses Nat. Rev. Immunol. (IF 100.3) Pub Date : 2024-03-06 Lucas Baldran-Groves, Jeroen Melief
A preprint by Zhou et al. shows that the clinical efficacy of immune checkpoint blockade in patients with cancer does not depend on the presence of tumour-draining lymph nodes, as their role is taken over by more distant lymph nodes.
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The receptor binding domain of SARS-CoV-2 Omicron subvariants targets Siglec-9 to decrease its immunogenicity by preventing macrophage phagocytosis Nat. Immunol. (IF 30.5) Pub Date : 2024-03-07 Xin He, Xiantao Zhang, Bolin Wu, Jieyi Deng, Yongli Zhang, Airu Zhu, Yaochang Yuan, Yingtong Lin, Achun Chen, Jinzhu Feng, Xiumei Wang, Shijian Wu, Yingying Liu, Jie Liu, Yalin Wang, Rong Li, Chaofeng Liang, Quyu Yuan, Yu Liang, Qiannan Fang, Zhihui Xi, Wenjie Li, Liting Liang, Zhenglai Zhang, Hui Tang, Yi Peng, Changwen Ke, Xiancai Ma, Weibin Cai, Ting Pan, Bingfeng Liu, Kai Deng, Jun Chen, Jincun
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Transmembrane domain–driven PD-1 dimers mediate T cell inhibition Sci. Immunol (IF 24.8) Pub Date : 2024-03-08 Elliot A. Philips, Jia Liu, Audun Kvalvaag, Alexander M. Mørch, Anna S. Tocheva, Charles Ng, Hong Liang, Ian M. Ahearn, Ruimin Pan, Christina C. Luo, Alexander Leithner, Zhihua Qin, Yong Zhou, Antonio Garcia-España, Adam Mor, Dan R. Littman, Michael L. Dustin, Jun Wang, Xiang-Peng Kong
Programmed cell death-1 (PD-1) is a potent immune checkpoint receptor on T lymphocytes. Upon engagement by its ligands, PD-L1 or PD-L2, PD-1 inhibits T cell activation and can promote immune tolerance. Antagonism of PD-1 signaling has proven effective in cancer immunotherapy, and conversely, agonists of the receptor may have a role in treating autoimmune disease. Some immune receptors function as dimers
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Subcapsular sinus macrophages maximize germinal center development in non-draining lymph nodes during blood-borne viral infection Sci. Immunol (IF 24.8) Pub Date : 2024-03-08 Cynthia C. Aguilar, Anurag Kalia, Morgan E. Brisse, Kimberly A. Dowd, Olivia Wise-Dent, Katherine E. Burgomaster, Joanna Droppo, Theodore C. Pierson, Heather D. Hickman
Lymph node (LN) germinal centers (GCs) are critical sites for B cell activation and differentiation. GCs develop after specialized CD169+ macrophages residing in LN sinuses filter antigens (Ags) from the lymph and relay these Ags into proximal B cell follicles. Many viruses, however, first reach LNs through the blood during viremia (virus in the blood), rather than through lymph drainage from infected
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Beyond T cell exhaustion: TIM-3 regulation of myeloid cells Sci. Immunol (IF 24.8) Pub Date : 2024-03-08 Karen O. Dixon, Gonzalo Fernandez Lahore, Vijay K. Kuchroo
T cell immunoglobulin and mucin domain-containing protein 3 (TIM-3) is an important immune checkpoint molecule initially identified as a marker of IFN-γ–producing CD4 + and CD8 + T cells. Since then, our understanding of its role in immune responses has significantly expanded. Here, we review emerging evidence demonstrating unexpected roles for TIM-3 as a key regulator of myeloid cell function, in
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Subcapsular sinus macrophages maximize germinal center development in non-draining lymph nodes during blood-borne viral infection Sci. Immunol (IF 24.8) Pub Date : 2024-03-08 Cynthia C. Aguilar, Anurag Kalia, Morgan E. Brisse, Kimberly A. Dowd, Olivia Wise-Dent, Katherine E. Burgomaster, Joanna Droppo, Theodore C. Pierson, Heather D. Hickman
Lymph node (LN) germinal centers (GCs) are critical sites for B cell activation and differentiation. GCs develop after specialized CD169 + macrophages residing in LN sinuses filter antigens (Ags) from the lymph and relay these Ags into proximal B cell follicles. Many viruses, however, first reach LNs through the blood during viremia (virus in the blood), rather than through lymph drainage from infected
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Transmembrane domain–driven PD-1 dimers mediate T cell inhibition Sci. Immunol (IF 24.8) Pub Date : 2024-03-08 Elliot A. Philips, Jia Liu, Audun Kvalvaag, Alexander M. Mørch, Anna S. Tocheva, Charles Ng, Hong Liang, Ian M. Ahearn, Ruimin Pan, Christina C. Luo, Alexander Leithner, Zhihua Qin, Yong Zhou, Antonio Garcia-España, Adam Mor, Dan R. Littman, Michael L. Dustin, Jun Wang, Xiang-Peng Kong
Programmed cell death-1 (PD-1) is a potent immune checkpoint receptor on T lymphocytes. Upon engagement by its ligands, PD-L1 or PD-L2, PD-1 inhibits T cell activation and can promote immune tolerance. Antagonism of PD-1 signaling has proven effective in cancer immunotherapy, and conversely, agonists of the receptor may have a role in treating autoimmune disease. Some immune receptors function as dimers
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Lupus autoantibodies initiate neuroinflammation sustained by continuous HMGB1:RAGE signaling and reversed by increased LAIR-1 expression Nat. Immunol. (IF 30.5) Pub Date : 2024-03-06 Kaitlin R. Carroll, Mark Mizrachi, Sean Simmons, Bahtiyar Toz, Czeslawa Kowal, Jeffrey Wingard, Nazila Tehrani, Aida Zarfeshani, Nina Kello, Lara El Khoury, Rachel Weissman-Tsukamoto, Joshua Z. Levin, Bruce T. Volpe, Betty Diamond
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Differentiation route determines the functional outputs of adult megakaryopoiesis Immunity (IF 32.4) Pub Date : 2024-03-05 Jing-Jing Li, Jingkun Liu, Yunqian Evelyn Li, Lin Veronica Chen, Hui Cheng, Yueying Li, Tao Cheng, Qian-Fei Wang, Bo O. Zhou
Emerging evidence has revealed a direct differentiation route from hematopoietic stem cells to megakaryocytes (direct route), in addition to the classical differentiation route through a series of restricted hematopoietic progenitors (stepwise route). This raises the question of the importance of two alternative routes for megakaryopoiesis. Here, we developed fate-mapping systems to distinguish the
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Tuning of plasma cell lifespan by competition explains the longevity and heterogeneity of antibody persistence Immunity (IF 32.4) Pub Date : 2024-03-05 Benjamin D. Simons, Omer Karin
Plasma cells that emerge after infection or vaccination exhibit heterogeneous lifespans; most survive for days to months, whereas others persist for decades, providing antigen-specific long-term protection. We developed a mathematical framework to explore the dynamics of plasma cell removal and its regulation by survival factors. Analyses of antibody persistence following hepatitis A and B and HPV
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CD4+ T cell activation distinguishes response to anti-PD-L1+anti-CTLA4 therapy from anti-PD-L1 monotherapy Immunity (IF 32.4) Pub Date : 2024-03-04 Amelie Franken, Michel Bila, Aurelie Mechels, Sam Kint, Jeroen Van Dessel, Valentina Pomella, Sebastiaan Vanuytven, Gino Philips, Orian Bricard, Jieyi Xiong, Bram Boeckx, Sigrid Hatse, Thomas Van Brussel, Rogier Schepers, Cedric Van Aerde, Sarah Geurs, Vincent Vandecaveye, Esther Hauben, Vincent Vander Poorten, Sara Verbandt, Katy Vandereyken, Junbin Qian, Sabine Tejpar, Thierry Voet, Paul M. Clement
Cancer patients often receive a combination of antibodies targeting programmed death-ligand 1 (PD-L1) and cytotoxic T lymphocyte antigen-4 (CTLA4). We conducted a window-of-opportunity study in head and neck squamous cell carcinoma (HNSCC) to examine the contribution of anti-CTLA4 to anti-PD-L1 therapy. Single-cell profiling of on- versus pre-treatment biopsies identified T cell expansion as an early
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Learning from cancer mutations Nat. Immunol. (IF 30.5) Pub Date : 2024-03-01 Nicholas J. Bernard
T cell lymphomas acquire mutations that endow them with advantages to endure the immunosuppressive tumor microenvironment. Researchers have now found a way to turn the tables on cancer by using these mutations to develop more effective chimeric antigen receptor (CAR) T cell therapies. In a study published in Nature, the authors created a barcoded library of mutant genes from T cell malignancies and
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Complement profile Nat. Immunol. (IF 30.5) Pub Date : 2024-03-01 Ioana Staicu
Severe COVID-19 has been associated with complement activation, hypercoagulation and vascular injury. In Science, Cervia-Hasler et al. report persistent complement-mediated immunopathology and thromboinflammation in long COVID as well. High-throughput proteomics on serum from 113 SARS-CoV-2-infected individuals (40 of which reported persisting symptoms at 6 months) at acute and 6 months after severe
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Surface RNAs move neutrophils Nat. Immunol. (IF 30.5) Pub Date : 2024-03-01 Paula Jáuregui
RNAs have been detected on the outer surface of mammalian cells, including some with glycan modifications known as glycoRNAs; however, the biological function of these surface molecules is unclear. Research now published in Cell shows that on neutrophils these RNAs are required for efficient recruitment, adhesion and transendothelial migration at inflammatory sites in mice. Using extracellular RNase
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What Jane Jacobs has taught me about neuroimmunology Nat. Immunol. (IF 30.5) Pub Date : 2024-03-01 Jennifer L. Gommerman
In acknowledgment of Women’s History Month, I have drawn upon timeless concepts from Jane Jacobs’ seminal 1961 book The Death and Life of Great American Cities1 to describe emerging ideas in neuroimmunology and how we may collectively move the field forward.
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Opening the doors of opportunity Nat. Immunol. (IF 30.5) Pub Date : 2024-03-01 Noriko Isobe
Breakdown barriers that make you hesitate from challenging yourself, and jump into new fields that interest you.
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Marching forward in neuroimmunology Nat. Immunol. (IF 30.5) Pub Date : 2024-03-01
As part of Women’s History Month, we are celebrating the contributions of women who stand at the crossroads of immunology and neurobiology.
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Neuroimmunology, women scientists and dogma Nat. Immunol. (IF 30.5) Pub Date : 2024-03-01 Robyn S. Klein
Reflecting on the decision to become a neuroimmunologist, and the women mentors who taught me how to challenge dogma in all its forms.
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Alterations of iron homeostasis as a potential druggable driver of long COVID Nat. Immunol. (IF 30.5) Pub Date : 2024-03-01 Oriana Marques, Martina U. Muckenthaler
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Neuroimmunology, the field that welcomed me and made me want to stay Nat. Immunol. (IF 30.5) Pub Date : 2024-03-01 Irene Salinas
Entering a new scientific field is difficult and daunting. Here I relate my personal journey as a fish immunologist and how neuroimmunologists welcomed me with open arms (and brains), giving me the sense of belonging that we all need as scientists.
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Unveiling the antitumor function of ID3 in liver macrophages Nat. Immunol. (IF 30.5) Pub Date : 2024-03-01 Anne-Gaëlle Goubet, Mikaël J. Pittet
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Success without intervention: keeping the conversation open Nat. Immunol. (IF 30.5) Pub Date : 2024-03-01 Fabienne Brilot
Since the discoveries of autoantibodies in neurological diseases, women have had a fascinating journey in neuroimmunology. At a time when groundbreaking advances are being made, let’s continue the conversation about women in science.
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Iron dysregulation and inflammatory stress erythropoiesis associates with long-term outcome of COVID-19 Nat. Immunol. (IF 30.5) Pub Date : 2024-03-01 Aimee L. Hanson, Matthew P. Mulè, Hélène Ruffieux, Federica Mescia, Laura Bergamaschi, Victoria S. Pelly, Lorinda Turner, Prasanti Kotagiri, Berthold Göttgens, Christoph Hess, Nicholas Gleadall, John R. Bradley, James A. Nathan, Paul A. Lyons, Hal Drakesmith, Kenneth G. C. Smith
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Atopic Dermatitis Phenotypes Impact Expression of Atopic Diseases Despite Similar Mononuclear Cell Cytokine Responses J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2024-03-02 Mohamed H. Taki, Kristine E. Lee, Ronald Gangnon, James E. Gern, Robert F. Lemanske, Daniel J. Jackson, Anne Marie Singh
The atopic march refers to the co-expression and progression of atopic diseases in childhood, often beginning with atopic dermatitis, although children may not “progress” through each atopic disease. We hypothesized that future atopic disease expression is modified by atopic dermatitis phenotype, and that these differences result from underlying dysregulation of cytokine signaling. Children (n=285)
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Loss-of-phosphorylation of IKZF1 results in gain-of-function associated with immune dysregulation J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2024-03-02 Akihiro Hoshino, Benoît Heid Picard, Sophia Polychronopoulou, Charikleia Kelaidi, Saba Azarnoush, Sven Kracker, Frédéric Rieux-Laucat, David Boutboul, Sylvain Latour
Immune dysregulation often presents as autoimmunity, inflammation and/or lymphoproliferation. Several germline genetic defects have been associated with immune dysregulation including heterozygous gain-of-function (GOF) mutations in , an essential transcription factor for hematopoiesis containing zinc finger domains (ZFs). However, in a large part of patients the genetic origin of their immunedysregulation
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Pre-existing antibody allows for maturation of new B cells in ‘recall’ germinal centres Nat. Rev. Immunol. (IF 100.3) Pub Date : 2024-03-01 Jake Herb, Maria Curotto de Lafaille
Re-exposure to a previously encountered antigen leads to robust antibody responses and the formation of ‘recall’ germinal centres. A preprint by Schiepers et al. shows that antibody feedback in these germinal centres ensures the maturation of naive B cells that can target escape epitopes.
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Osteoblast-derived ATP maintains bone marrow plasma cells Nat. Rev. Immunol. (IF 100.3) Pub Date : 2024-02-29 Yvonne Bordon
Plasma cells use P2RX4 to sense the regulated release of ATP from osteoblasts and this protects against ER stress-driven apoptosis.
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The transcription factor NF-κB orchestrates nucleosome remodeling during the primary response to Toll-like receptor 4 signaling Immunity (IF 32.4) Pub Date : 2024-03-01 An-Chieh Feng, Brandon J. Thomas, Prabhat K. Purbey, Filipe Menegatti de Melo, Xin Liu, Allison E. Daly, Fei Sun, Jerry Hung-Hao Lo, Lijing Cheng, Michael F. Carey, Philip O. Scumpia, Stephen T. Smale
Inducible nucleosome remodeling at hundreds of latent enhancers and several promoters shapes the transcriptional response to Toll-like receptor 4 (TLR4) signaling in macrophages. We aimed to define the identities of the transcription factors that promote TLR-induced remodeling. An analysis strategy based on ATAC-seq and single-cell ATAC-seq that enriched for genomic regions most likely to undergo remodeling
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Protective human monoclonal antibodies target conserved sites of vulnerability on the underside of influenza virus neuraminidase Immunity (IF 32.4) Pub Date : 2024-03-01 Julia Lederhofer, Yaroslav Tsybovsky, Lam Nguyen, Julie E. Raab, Adrian Creanga, Tyler Stephens, Rebecca A. Gillespie, Hubza Z. Syeda, Brian E. Fisher, Michelle Skertic, Christina Yap, Andrew J. Schaub, Reda Rawi, Peter D. Kwong, Barney S. Graham, Adrian B. McDermott, Sarah F. Andrews, Neil P. King, Masaru Kanekiyo
Continuously evolving influenza viruses cause seasonal epidemics and pose global pandemic threats. Although viral neuraminidase (NA) is an effective drug and vaccine target, our understanding of the NA antigenic landscape still remains incomplete. Here, we describe NA-specific human antibodies that target the underside of the NA globular head domain, inhibit viral propagation of a wide range of human
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Recurrent infections drive persistent bladder dysfunction and pain via sensory nerve sprouting and mast cell activity Sci. Immunol (IF 24.8) Pub Date : 2024-03-01 Byron W. Hayes, Hae Woong Choi, Abhay P.S. Rathore, Chunjing Bao, Jianling Shi, Yul Huh, Michael W. Kim, Andrea Mencarelli, Pradeep Bist, Lai Guan Ng, Changming Shi, Joo Hwan Nho, Aram Kim, Hana Yoon, Donghoon Lim, Johanna L. Hannan, J. Todd Purves, Francis M. HughesJr., Ru-Rong Ji, Soman N. Abraham
Urinary tract infections (UTIs) account for almost 25% of infections in women. Many are recurrent (rUTI), with patients frequently experiencing chronic pelvic pain and urinary frequency despite clearance of bacteriuria after antibiotics. To elucidate the basis for these bacteria-independent bladder symptoms, we examined the bladders of patients with rUTI. We noticed a notable increase in neuropeptide