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Author Correction: β-Glucan reprograms neutrophils to promote disease tolerance against influenza A virus Nat. Immunol. (IF 27.7) Pub Date : 2025-02-07 Nargis Khan, Kim A. Tran, Raphael Chevre, Veronica Locher, Mathis Richter, Sarah Sun, Mina Sadeghi, Erwan Pernet, Andrea Herrero-Cervera, Alexandre Grant, Ahmed Saif, Jeffrey Downey, Eva Kaufmann, Shabaana Abdul Khader, Philippe Joubert, Luis B. Barreiro, Bryan G. Yipp, Oliver Soehnlein, Maziar Divangahi
Correction to: Nature Immunology https://doi.org/10.1038/s41590-024-02041-2, published online 8 January 2025.
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Faulty mitochondria jump between tumours and T cells Nat. Rev. Immunol. (IF 67.7) Pub Date : 2025-02-07 Lucy Bird
To evade elimination by T cells, tumour cells transfer mutant mitochondria to T cells, which reprogrammes their metabolism and compromises their antitumour activity.
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Insights into autoimmunity and cancer Nat. Immunol. (IF 27.7) Pub Date : 2025-02-07 Xinrui Li, Carmen Ufret-Vincenty, Jacqueline Robinson-Hamm, Lillian Kuo, Heiyoung Park, Victoria K. Shanmugam
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Molecular determinants of cross-strain influenza A virus recognition by αβ T cell receptors Sci. Immunol (IF 17.6) Pub Date : 2025-02-07 Sergio M. Quiñones-Parra, Stephanie Gras, Thi H. O. Nguyen, Carine Farenc, Christopher Szeto, Louise C. Rowntree, Priyanka Chaurasia, Sneha Sant, Adrianus C. M. Boon, Dhilshan Jayasinghe, Guus F. Rimmelzwaan, Jan Petersen, Peter C. Doherty, Adam P. Uldrich, Dene R. Littler, Jamie Rossjohn, Katherine Kedzierska
Cross-reactive αβ T cell receptors (TCRs) recognizing multiple peptide variants can provide effective control of rapidly evolving viruses yet remain understudied. By screening 12 naturally occurring influenza-derived HLA-B*35:01–restricted nucleoprotein (NP) 418–426 epitopes (B*35:01-NP 418 ) that emerged since 1918 within influenza A viruses, including 2024 A/H5N1 viruses, we identified functional
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Bone marrow breakout lesions act as key sites for tumor-immune cell diversification in multiple myeloma Sci. Immunol (IF 17.6) Pub Date : 2025-02-07 Raphael Lutz, Alexandra M. Poos, Llorenç Solé-Boldo, Lukas John, Johanna Wagner, Nina Prokoph, Marc A. Baertsch, Dominik Vonficht, Subarna Palit, Alexander Brobeil, Gunhild Mechtersheimer, Nina Hildenbrand, Stefan Hemmer, Simon Steiger, Sabrina Horn, Wojciech Pepke, David M. Spranz, Christoph Rehnitz, Pooja Sant, Jan-Philipp Mallm, Mirco J. Friedrich, Philipp Reichert, Stefanie Huhn, Andreas Trumpp
The bone marrow microenvironment plays a crucial role in the development of multiple myeloma. As the disease progresses, malignant myeloma cells can evolve to survive outside the bone marrow. However, the processes underlying bone marrow independence and their consequences for immune control remain poorly understood. Here, we conducted single-cell and spatial multiomics analyses of bone marrow–confined
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IL-4 induces CD22 expression to restrain the effector program of virtual memory T cells Sci. Immunol (IF 17.6) Pub Date : 2025-02-07 Bin Yang, Ophélie Piedfort, Guillem Sanchez-Sanchez, Arnaud Lavergne, Meijiao Gong, Garrie Peng, Ariel Madrigal, Georgios Petrellis, Brunette Katsandegwaza, Lucia Rodriguez Rodriguez, Alexis Balthazar, Sarah J. Meyer, Gert Van Isterdael, Julie Van Duyse, Fabienne Andris, Qiang Bai, Thomas Marichal, Bénédicte Machiels, Lars Nitschke, Hamed S. Najafabadi, Irah L. King, David Vermijlen, Benjamin G. Dewals
Parasitic helminths induce the production of interleukin-4 (IL-4), which causes the expansion of virtual memory CD8 + T cells (T VM cells), a cell subset that contributes to the control of coinfection with intracellular pathogens. However, the mechanisms regulating IL-4–dependent T VM cell activation and expansion remain ill defined. Here, we used single-cell RNA sequencing of CD8 + T cells to identify
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B cells in non-lymphoid tissues Nat. Rev. Immunol. (IF 67.7) Pub Date : 2025-02-05 Abrar Samiea, George Celis, Rashi Yadav, Lauren B. Rodda, Joshua M. Moreau
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In vivo engineering of murine T cells using the evolved adeno-associated virus variant Ark313 Immunity (IF 25.5) Pub Date : 2025-02-04 William A. Nyberg, Charlotte H. Wang, Jonathan Ark, Chang Liu, Sylvanie Clouden, Anita Qualls, Sofia Caryotakis, Elina Wells, Katherine Simon, Celeste Garza, Pierre-Louis Bernard, Maya Lopez-Ichikawa, Zhongmei Li, Jin Seo, Gabriella R. Kimmerly, Joseph J. Muldoon, Peixin Amy Chen, Mingcheng Li, Hong-Erh Liang, Kelly Kersten, Justin Eyquem
Genetic engineering of T cells in mouse models is essential for investigating immune mechanisms. We aimed to develop an approach to manipulate T cells in vivo using an evolved adeno-associated virus (AAV) capsid named Ark313. Delivery of a transient transgene expression cassette was feasible using Ark313, and this serotype outperformed natural serotypes. A single intravenous injection of a Cre recombinase-expressing
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Structural basis for complement receptor engagement and virus neutralization through Epstein-Barr virus gp350 Immunity (IF 25.5) Pub Date : 2025-02-04 M. Gordon Joyce, Wei Bu, Wei-Hung Chen, Rebecca A. Gillespie, Sarah F. Andrews, Adam K. Wheatley, Yaroslav Tsybovsky, Jaime L. Jensen, Tyler Stephens, Madhu Prabhakaran, Brian E. Fisher, Sandeep R. Narpala, Meghna Bagchi, Adrian B. McDermott, Gary J. Nabel, Peter D. Kwong, John R. Mascola, Jeffrey I. Cohen, Masaru Kanekiyo
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The lactate receptor HCAR1 drives the recruitment of immunosuppressive PMN-MDSCs in colorectal cancer Nat. Immunol. (IF 27.7) Pub Date : 2025-02-04 Jiacheng He, Xiaolei Chai, Qiansen Zhang, Yang Wang, Yijie Wang, Xinyu Yang, Jingbo Wu, Bo Feng, Jing Sun, Weiwei Rui, Shuyin Ze, Yuanyuan Fu, Yumiao Zhao, Ying Zhang, Yao Zhang, Meizhen Liu, Chuang Liu, Meifu She, Xiangfei Hu, Xueyun Ma, Huaiyu Yang, Dawei Li, Senlin Zhao, Guichao Li, Zhen Zhang, Zhonghui Tian, Yanlin Ma, Lingyan Cao, Bo Yi, Dali Li, Ruth Nussinov, Charis Eng, Timothy A. Chan, Eytan
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Terminal differentiation and persistence of effector regulatory T cells essential for preventing intestinal inflammation Nat. Immunol. (IF 27.7) Pub Date : 2025-02-04 Stanislav Dikiy, Aazam P. Ghelani, Andrew G. Levine, Stephen Martis, Paolo Giovanelli, Zhong-Min Wang, Giorgi Beroshvili, Yuri Pritykin, Chirag Krishna, Xiao Huang, Ariella Glasner, Benjamin D. Greenbaum, Christina S. Leslie, Alexander Y. Rudensky
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Integrated control of leukocyte compartments as a feature of adaptive physiology Immunity (IF 25.5) Pub Date : 2025-02-04 Nikolai P. Jaschke, Andrew Wang
As a highly diverse and mobile organ, the immune system is uniquely equipped to participate in tissue responses in a tunable manner, depending on the number, type, and nature of cells deployed to the respective organ. Most acute organismal stressors that threaten survival—predation, infection, poisoning, and others—induce pronounced redistribution of immune cells across tissue compartments. Here, we
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Clinical, immunologic and genetic characteristics of 148 patients with NK cell deficiency. J. Allergy Clin. Immunol. (IF 11.4) Pub Date : 2025-02-04 Manar Abdalgani,Evelyn R Hernandez,Luis A Pedroza,Ivan K Chinn,Lisa R Forbes Satter,Nicholas L Rider,Pinaki P Banerjee,M Cecilia Poli,Sanjana Mahaptra,Debra Canter,Tram Cao,Linda M Shawver,Sara Nandiwada,James R Lupski,Jennifer Posey,Rajasekhar Ramakrishnan,Emily M Mace,Jordan S Orange
BACKGROUND Natural killer (NK) cell deficiency (NKD) is an immunodeficiency phenotype in which abnormality of NK cells is the major clinically relevant immune defect. OBJECTIVE We sought to define the clinical, immunologic and genetic characteristics of patients with NKD to aid in the understanding of these individuals and this cell type, and guide future research and clinical practice. METHODS During
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Sputum short-chain fatty acids, microbiome, inflammation, and mucus plugging in obstructive airway disease. J. Allergy Clin. Immunol. (IF 11.4) Pub Date : 2025-02-04 Naoya Tanabe,Hisako Matsumoto,Chie Morimoto,Toyohiro Hirai
BACKGROUND Short-chain fatty acids (SCFAs), produced by anaerobic bacteria through fermentation in the gut, may suppress eosinophilic inflammation while potentially promoting neutrophilic inflammation. However, the role of local SCFAs in airway microbiome, inflammation, and mucus plugging in type 2 dominant obstructive airway diseases remains unclear. OBJECTIVE To investigate associations between sputum
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NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer’s disease progression Immunity (IF 25.5) Pub Date : 2025-02-03 Róisín M. McManus, Max P. Komes, Angelika Griep, Francesco Santarelli, Stephanie Schwartz, Juan Ramón Perea, Johannes C.M. Schlachetzki, David S. Bouvier, Michelle-Amirah Khalil, Mario A. Lauterbach, Lea Heinemann, Titus Schlüter, Mehran Shaban Pour, Marta Lovotti, Rainer Stahl, Fraser Duthie, Juan F. Rodríguez-Alcázar, Susanne V. Schmidt, Jasper Spitzer, Peri Noori, Michael T. Heneka
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Inclusion of ACKR5 in the systematic nomenclature of atypical chemokine receptors Nat. Rev. Immunol. (IF 67.7) Pub Date : 2025-02-03 Martyna Szpakowska, Daniel F. Legler, Stefan Offermanns, Silvano Sozzani, Antal Rot, Marcus Thelen, Andy Chevigné
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Podoplanin mediates stromal–immune crosstalk in the lymph node Nat. Rev. Immunol. (IF 67.7) Pub Date : 2025-01-31 Erika E. McCartney, Matthew B. Buechler
A preprint by Makris et al. shows that podoplanin is a key regulator of the functions of fibroblastic reticular cells in lymph nodes, by modulating interactions with immune cells.
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Trained immunity in chronic inflammatory diseases and cancer Nat. Rev. Immunol. (IF 67.7) Pub Date : 2025-01-31 George Hajishengallis, Mihai G. Netea, Triantafyllos Chavakis
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Human versus mouse PD-1 Nat. Immunol. (IF 27.7) Pub Date : 2025-01-31 Ioana Staicu
Engagement of the immune checkpoint receptor PD-1 by its ligand PD-L1 triggers recruitment and activation of the phosphatase SHP2, which dephosphorylates T cell receptor (TCR) components and costimulatory signaling pathways. In Science Immunology, Masubuchi et al. show that mouse PD-1 has a reduced inhibitory function compared with human PD-1. Titration experiments in human Jurkat T cells, mouse DO11
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Exhaustion is planned Nat. Immunol. (IF 27.7) Pub Date : 2025-01-31 Nicholas J. Bernard
CD8+ T cell exhaustion has been thought to occur only in the context of chronic antigen persistence, such as in cancer or chronic viral infections. However, two papers now published in Nature show that these cells and their precursors are present in the early stages of an acute infection with lymphocytic choriomeningitis virus in mice. In one of the studies, they also detected virus-specific stem-like
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Recruiting lymphocytes Nat. Immunol. (IF 27.7) Pub Date : 2025-01-31 Laurie A. Dempsey
Circulating naive lymphocytes are recruited from the blood to homeostatic lymph nodes (LNs) by the chemokines CCL19 and CCL21, which are ligands for the CCR7 receptor. However, upon infection and inflammation, reactive LNs undergo structural changes and alter their gene expression to facilitate lymphocyte activation. In Cell, Chen et al. examine how inflammation alters the chemotactic signals for LN
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Tolerance during infection Nat. Immunol. (IF 27.7) Pub Date : 2025-01-31 Stephanie Houston
Antigen-presenting cells (APCs) in the intestine maintain the delicate balance between the induction of immunity against invading pathogens and immune tolerance to food and commensal bacteria, but which APCs contribute to tolerance and how this changes during infection are unclear. In Science, Canesso et al. find that conventional type 1 dendritic cells (cDC1s) contribute to food-specific induction
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A symphony of immunity to SARS-CoV-2 in the adenoids Nat. Immunol. (IF 27.7) Pub Date : 2025-01-31 Kalpana Manthiram, Qin Xu, Pamela L. Schwartzberg
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Temporal profiling of human lymphoid tissues reveals coordinated defense against viral challenge Nat. Immunol. (IF 27.7) Pub Date : 2025-01-31 Matthew L. Coates, Nathan Richoz, Zewen K. Tuong, Georgina S. Bowyer, Colin Y. C. Lee, John R. Ferdinand, Eleanor Gillman, Mark McClure, Lisa Dratva, Sarah A. Teichmann, David R. Jayne, Rafael Di Marco Barros, Benjamin J. Stewart, Menna R. Clatworthy
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Eosinophils promote the production of autoantibodies in bullous pemphigoid. J. Allergy Clin. Immunol. (IF 11.4) Pub Date : 2025-02-01 Hideyuki Ujiie
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Outcome of hematopoietic stem cell transplantation for SCID and impact of newborn screening on overall survival - A single referral center study. J. Allergy Clin. Immunol. (IF 11.4) Pub Date : 2025-02-01 Chen Anchoo,Atar Lev,Amos J Simon,Shiran Levy,Amarilla Mandola,Shirly Frizinsky,Ido Somekh,NaserEddin Adeeb,Rabee S A Adwan,Amos Toren,Hana Golan,Bella Bielorai,Daphna Hutt,Etai Adam,Raz Somech
BACKGROUND Hematopoietic stem cell transplantation (HSCT) is a curative treatment for infants with severe combined immunodeficiency (SCID). Different factors determine HSCT success and overall survival (OS). Specifically, prompt diagnosis of SCID, preferably through newborn screening (NBS), is critical. OBJECTIVE To explore variable factors including the impact of NBS that are associated with HSCT
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Lactylation-driven ALKBH5 diminishes macrophage NLRP3 inflammasome activation in patients with G6PT deficiency. J. Allergy Clin. Immunol. (IF 11.4) Pub Date : 2025-02-01 Zexiong Su,Jiaoli Lan,Ying Wang,Ni Ma,Jing Yang,Danxia Liang,Hanshi Zeng,Min Yang
BACKGROUND Neutropenia represents an important clinical problem in patients with glycogen storage disease type Ib (GSD-Ib), characterized by genetic deficiency in glucose-6-phosphate translocase (G6PT/SLC37A4). However, the role of G6PT in macrophages has not been elucidated. OBJECTIVE We sought to investigate the function of G6PT in macrophage inflammation. METHODS Functional assays (including immunoblotting
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Recirculating regulatory T cells mediate thymic regeneration through amphiregulin following damage Immunity (IF 25.5) Pub Date : 2025-01-31 Andri L. Lemarquis, Anastasia I. Kousa, Kimon V. Argyropoulos, Lorenz Jahn, Brianna Gipson, Jonah Pierce, Lucia Serrano-Marin, Kristen Victor, Yuzuka Kanno, Narina N. Girotra, Hana Andrlova, Jennifer Tsai, Enrico Velardi, Roshan Sharma, Simon Grassmann, Olov Ekwall, Andrew B. Goldstone, Jarrod A. Dudakov, Susan DeWolf, Marcel R.M. van den Brink
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Immune control of brain physiology Nat. Rev. Immunol. (IF 67.7) Pub Date : 2025-01-31 Mariángeles Kovacs, Amaia Dominguez-Belloso, Samir Ali-Moussa, Aleksandra Deczkowska
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Nutrient metabolism shapes epigenetic landscape of T cells Nat. Immunol. (IF 27.7) Pub Date : 2025-01-31 Annika Poch, Daniel T. Utzschneider
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Progressively differentiated TFH13 cells are stabilized by JunB to mediate allergen germinal center responses Nat. Immunol. (IF 27.7) Pub Date : 2025-01-31 Pragya Chandrakar, Cody S. Nelson, Manuel A. Podestà, Cecilia B. Cavazzoni, Maya Gempler, Jeong-Mi Lee, Sierra Richardson, Hengcheng Zhang, Snigdha Samarpita, Maria Ciofani, Talal Chatila, Vijay K. Kuchroo, Peter T. Sage
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Short IL-18 generated by caspase-3 cleavage mobilizes NK cells to suppress tumor growth Nat. Immunol. (IF 27.7) Pub Date : 2025-01-31 Junchen Shen, Yu Zhang, Wenbo Tang, Mingxia Yang, Tong Cheng, Yihui Chen, Shi Yu, Qiuhong Guo, Limin Cao, Xun Wang, Hui Xiao, Lanfeng Wang, Chengyuan Wang, Chen-Ying Liu, Guangxun Meng
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Trogocytosis of chimeric antigen receptors between T cells is regulated by their transmembrane domains Sci. Immunol (IF 17.6) Pub Date : 2025-01-31 Stefano Barbera, Matthijs J. A. Schuiling, Nathaniel A. Sanjaya, Ilkka Pietilä, Tina Sarén, Magnus Essand, Anna Dimberg
Trogocytosis is an exchange of membrane-associated molecules between cells that can either halt or boost immune responses. However, the mechanism that regulates trogocytosis in T cells and its consequences are not yet clear. Here, we demonstrate that T cells can exchange chimeric antigen receptors (CARs) by trogocytosis, thereby arming recipient T cells with the capacity to respond to tumor antigens
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Stem-like memory and precursors of exhausted T cells share a common progenitor defined by ID3 expression Sci. Immunol (IF 17.6) Pub Date : 2025-01-31 Catarina Gago da Graça, Amania A. Sheikh, Dane M. Newman, Lifen Wen, Sining Li, Jian Shen, Yuqi Zhang, Sarah S. Gabriel, David Chisanga, Justine Seow, Annika Poch, Lisa Rausch, Minh-Hanh T. Nguyen, Jayendra Singh, Chun-Hsi Su, Leonie A. Cluse, Carlson Tsui, Thomas N. Burn, Simone L. Park, Bianca Von Scheidt, Laura K. Mackay, Ajithkumar Vasanthakumar, David Bending, Wei Shi, Weiguo Cui, Jan Schröder
Stem-like T cells are attractive immunotherapeutic targets in patients with cancer given their ability to proliferate and differentiate into effector progeny. Thus, identifying T cells with enhanced stemness and understanding their developmental requirements are of broad clinical and therapeutic interest. Here, we demonstrate that during acute infection, the transcriptional regulator inhibitor of DNA
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Rapid validation of NLRP3 gain-of-function variants in cryopyrin-associated periodic syndromes. J. Allergy Clin. Immunol. (IF 11.4) Pub Date : 2025-01-31 Alex Quach,Yunyu Lao,Alexander Troelnikov,Pravin Hissaria,Damien Chan,Amanda Wells,Abhijit Kulkarni,Lesley Rawlings,Nicola Poplawski,Antonio Ferrante
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Bi-directional communication between intrinsic enteric neurons and ILC2s inhibits host defense against helminth infection Immunity (IF 25.5) Pub Date : 2025-01-30 Yinsheng Wang, Xiaoyu Zhang, Shaorui Liu, Zhijie Gu, Zijia Sun, Yang Zang, Xiaobao Huang, Yi Wang, Qiang Wang, Qingxia Lin, Ruichao Liu, Suhua Sun, Hongkai Xu, Jiali Wang, Tao Wu, Yan Wang, Yu Li, Hui Li, Zirun Tang, Yifan Qu, Coco Chu
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Identification of indirect CD4+ T cell epitopes associated with transplant rejection provides a target for donor-specific tolerance induction Immunity (IF 25.5) Pub Date : 2025-01-30 Zhuldyz Zhanzak, Aileen C. Johnson, Petra Foster, Maria A. Cardenas, Anna B. Morris, Joan Zhang, Geeta Karadkhele, I. Raul Badell, Alanna A. Morris, Byron B. Au-Yeung, Fernanda M. Roversi, Juliete A.F. Silva, Cynthia Breeden, Annette Hadley, Weiwen Zhang, Christian P. Larsen, Haydn T. Kissick
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Kidney immunology from pathophysiology to clinical translation Nat. Rev. Immunol. (IF 67.7) Pub Date : 2025-01-30 Christian Kurts, Sibylle von Vietinghoff, Christian F. Krebs, Ulf Panzer
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Antibody-secreting cell repertoires hold high-affinity anti-rocuronium specificities that can induce anaphylaxis in vivo. J. Allergy Clin. Immunol. (IF 11.4) Pub Date : 2025-01-30 Alice Dejoux,Qianqian Zhu,Adam Woolfe,Ophélie Godon,Sami Ellouze,Guillaume Mottet,Carlos Castrillon,Caitlin Gillis,Cyprien Pecalvel,Christelle Ganneau,Bruno Iannascoli,Frédéric Lemoine,Frederick Saul,Patrick England,Laurent L Reber,Aurélie Gouel-Chéron,Luc de Chaisemartin,Ahmed Haouz,Gaël A Millot,Sylvie Bay,Annabelle Gérard,Friederike Jönsson,Sylvie Chollet-Martin,Pierre Bruhns
BACKGROUND Neuromuscular blocking agents (NMBA) are muscle relaxants used to assist mechanical ventilation but lead in 1/10,000 anesthesia to severe acute hypersensitivity reactions i.e., anaphylaxis. Incidences vary between types of NMBAs. Rocuronium, a widely used non-depolarizing aminosteroid NMBA, induces among the highest anaphylaxis rates. Rocuronium-induced anaphylaxis is proposed to rely on
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Variant-specific local tissue response to SARS-CoV-2 in the nasal mucosa Nat. Immunol. (IF 27.7) Pub Date : 2025-01-29 Debbie van Baarle, Martijn C. Nawijn
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Single-cell profiling of the immune landscape across the human lifespan Nat. Immunol. (IF 27.7) Pub Date : 2025-01-29
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Integrating single-cell RNA and T cell/B cell receptor sequencing with mass cytometry reveals dynamic trajectories of human peripheral immune cells from birth to old age Nat. Immunol. (IF 27.7) Pub Date : 2025-01-29 Yufei Wang, Ronghong Li, Renyang Tong, Taiwei Chen, Mingze Sun, Lingjie Luo, Zheng Li, Yifan Chen, Yichao Zhao, Chensheng Zhang, Lin Wei, Wei Lin, Haoyan Chen, Kun Qian, Alex F. Chen, Junling Liu, Lei Chen, Bin Li, Feng Wang, Li Wang, Bing Su, Jun Pu
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Signature cytokine-associated transcriptome analysis of effector γδ T cells identifies subset-specific regulators of peripheral activation Nat. Immunol. (IF 27.7) Pub Date : 2025-01-29 Daniel Inácio, Tiago Amado, Ana Pamplona, Daniel Sobral, Carolina Cunha, Rita F. Santos, Liliana Oliveira, Nelly Rouquié, Alexandre M. Carmo, Renaud Lesourne, Anita Q. Gomes, Bruno Silva-Santos
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BNT162b2 COVID-19 vaccination elicits the expansion of CD16+CD8+ T cells endowed with Natural Killer cell features. J. Allergy Clin. Immunol. (IF 11.4) Pub Date : 2025-01-29 Claudia De Pasquale,Fabiana Drommi,Alessia Calabrò,Cirino Botta,Giacomo Sidoti Migliore,Paolo Carrega,Grazia Vento,Amirhossein Gaeini,Gaetana Pezzino,José Freni,Irene Bonaccorsi,Massimo Vitale,Gilberto Filaci,Daniela Fenoglio,Raffaella Iemmo,Gregorio Costa,Riccardo Cavaliere,Guido Ferlazzo,Stefania Campana
BACKGROUND The Pfizer/BioNtech vaccine, also known as BNT162b2, was developed using a novel technology based on mRNA and protects against COVID-19 via induction of specific antibody and T-cell responses. Much less is known about the broader effects of this new class of vaccines on unconventional cellular components of the immune system. OBJECTIVE We aimed to characterize a subset of unconventional
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The role of mitochondrial DNA copy number in asthma: Agent or bystander? J. Allergy Clin. Immunol. (IF 11.4) Pub Date : 2025-01-29 Anurag Agrawal,Ira Agrawal,George Davey Smith
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A cis-regulatory element controls expression of histone deacetylase 9 to fine-tune inflammasome-dependent chronic inflammation in atherosclerosis Immunity (IF 25.5) Pub Date : 2025-01-28 Yaw Asare, Guangyao Yan, Christina Schlegl, Matthias Prestel, Emiel P.C. van der Vorst, Abraham J.P. Teunissen, Arailym Aronova, Federica Tosato, Nawraa Naser, Julio Caputo, Geoffrey Prevot, Anthony Azzun, Benedikt Wefers, Wolfgang Wurst, Melanie Schneider, Ignasi Forne, Kiril Bidzhekov, Ronald Naumann, Sander W. van der Laan, Markus Brandhofer, Martin Dichgans
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An inter-organ neuro–immuno–endocrine circuit for glucose homeostasis Nat. Rev. Immunol. (IF 67.7) Pub Date : 2025-01-28 Kirsty Minton
A study in Science reports that intestinal innate lymphoid cells migrate to the pancreas in response to low blood glucose levels to promote glucagon production.
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Beyond bacteria: Phanta adds flavour to microbiome profiling with a focus on phages Nat. Rev. Immunol. (IF 67.7) Pub Date : 2025-01-28 Yishay Pinto
In this Tools of the Trade article, Yishay Pinto describes a tool, called Phanta, that profiles phages alongside their bacterial hosts in microbiome analysis.
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Biomolecular condensates in immune cell fate Nat. Rev. Immunol. (IF 67.7) Pub Date : 2025-01-28 Srikanth Kodali, Caroline M. Sands, Lei Guo, Yun Huang, Bruno Di Stefano
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Evasion of T cell responses by newly emerging SARS-CoV-2 variants Nat. Immunol. (IF 27.7) Pub Date : 2025-01-28
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T cell immune evasion by SARS-CoV-2 JN.1 escapees targeting two cytotoxic T cell epitope hotspots Nat. Immunol. (IF 27.7) Pub Date : 2025-01-28 Jinmin Tian, Bingli Shang, Jianing Zhang, Yuanyuan Guo, Min Li, Yuechao Hu, Dan Bai, Junying She, Yang Han, Peipei Guo, Mengkun Huang, Yalan Wang, Maoshun Liu, Jie Zhang, Beiwei Ye, Yaxin Guo, Mengjie Yang, Ying Lin, Ting Zhang, Xin Sun, Xiaoju Yuan, Danni Zhang, Ziqian Xu, Yan Chai, Jianxun Qi, Kefang Liu, Shuguang Tan, Yingze Zhao, Jikun Zhou, Rui Song, George F. Gao, Jun Liu
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Robust mucosal SARS-CoV-2-specific T cells effectively combat COVID-19 and establish polyfunctional resident memory in patient lungs Nat. Immunol. (IF 27.7) Pub Date : 2025-01-28 Airu Zhu, Zhao Chen, Qihong Yan, Mei Jiang, Xuesong Liu, Zhengtu Li, Na Li, Chunli Tang, Wenhua Jian, Jiangping He, Lan Chen, Jinling Cheng, Canjie Chen, Tian Tang, Zhiwei Xu, Qingtao Hu, Fang Li, Yanqun Wang, Jing Sun, Zhen Zhuang, Liyan Wen, Jianfen Zhuo, Donglan Liu, Yanjun Zhang, Xiaofang Huang, Suxiang Li, Qiuhui Zeng, Fangli Chen, Liang Zhou, Dongdong Liu, Changhao Zhong, Yu Chen, Shiyue Li,
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The meninges host a distinct compartment of regulatory T cells that preserves brain homeostasis Sci. Immunol (IF 17.6) Pub Date : 2025-01-28 Miguel Marin-Rodero, Elisa Cintado, Alec J. Walker, Teshika Jayewickreme, Felipe A. Pinho-Ribeiro, Quentin Richardson, Ruaidhrí Jackson, Isaac M. Chiu, Christophe Benoist, Beth Stevens, José Luís Trejo, Diane Mathis
Our understanding of the meningeal immune system has recently burgeoned, particularly regarding how innate and adaptive effector cells are mobilized to meet brain challenges. However, information on how meningeal immunocytes guard brain homeostasis in healthy individuals remains limited. This study highlights the heterogeneous, polyfunctional regulatory T cell (T reg ) compartment in the meninges.
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Innate immune function in chronic rhinosinusitis. J. Allergy Clin. Immunol. (IF 11.4) Pub Date : 2025-01-28 Robert J Lee,Noam A Cohen
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Distinct functions of CD4+ and CD8+ regulatory T cells in autoimmunity Nat. Immunol. (IF 27.7) Pub Date : 2025-01-27 Ziyang Xu, Bing Su
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Anaphylaxis definition, overview, and clinical support tool: 2024 consensus report. J. Allergy Clin. Immunol. (IF 11.4) Pub Date : 2025-01-27 Timothy E Dribin,Antonella Muraro,Carlos A Camargo,Paul J Turner,Julie Wang,Graham Roberts,Aikaterini Anagnostou,Susanne Halken,Jay Liebermann,Margitta Worm,Torsten Zuberbier,Hugh A Sampson,
BACKGROUND The 2006 National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network (NIAID/FAAN) anaphylaxis criteria are widely used in clinical care and research. In 2020, the World Allergy Organization (WAO) published modified criteria that have not been uniformly adopted. Different criteria contribute to inconsistent care and research outcomes. OBJECTIVE To develop a consensus
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Spatially restricted and ontogenically distinct hepatic macrophages are required for tissue repair Immunity (IF 25.5) Pub Date : 2025-01-24 Federico F. De Ponti, Anna Bujko, Zhuangzhuang Liu, Paul J. Collins, Sara Schuermans, Christian Maueroder, Seraja Amstelveen, Tinne Thoné, Liesbet Martens, John G. McKendrick, Pieter A. Louwe, Ana Sànchez Cruz, Wouter Saelens, Kylie P. Matchett, Kathryn J. Waller, Christian Zwicker, Aimée Buglar-Lamb, Bavo Vanneste, Fleur Parmentier, Mushida Binte Abdul Latib, Charlotte L. Scott
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ImmunOctoberfest reloaded Nat. Immunol. (IF 27.7) Pub Date : 2025-01-24 Anna M. Schulz, Caitlin C. Zebley, Ben Youngblood, Dietmar Zehn
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NIAID workshop on infections and autoimmune diseases Nat. Immunol. (IF 27.7) Pub Date : 2025-01-24 Stacy E. Ferguson, Annette L. Rothermel, Patricia Rohan, Rajeev Gautam, Deborah L. Hodge
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Coordinated immune networks in leukemia bone marrow microenvironments distinguish response to cellular therapy Sci. Immunol (IF 17.6) Pub Date : 2025-01-24 Katie Maurer, Cameron Y. Park, Shouvik Mani, Mehdi Borji, Florian Raths, Kenneth H. Gouin, Livius Penter, Yinuo Jin, Jia Yi Zhang, Crystal Shin, James R. Brenner, Jackson Southard, Sachi Krishna, Wesley Lu, Haoxiang Lyu, Domenic Abbondanza, Chanell Mangum, Lars Rønn Olsen, Michael J. Lawson, Martin Fabani, Donna S. Neuberg, Pavan Bachireddy, Eli N. Glezer, Samouil L. Farhi, Shuqiang Li, Kenneth J.
Understanding how intratumoral immune populations coordinate antitumor responses after therapy can guide treatment prioritization. We systematically analyzed an established immunotherapy, donor lymphocyte infusion (DLI), by assessing 348,905 single-cell transcriptomes from 74 longitudinal bone marrow samples of 25 patients with relapsed leukemia; a subset was evaluated by both protein- and transcriptome-based