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Classical monocyte ontogeny dictates their functions and fates as tissue macrophages Immunity (IF 32.4) Pub Date : 2024-05-14 Sébastien Trzebanski, Jung-Seok Kim, Niss Larossi, Ayala Raanan, Daliya Kancheva, Jonathan Bastos, Montaser Haddad, Aryeh Solomon, Ehud Sivan, Dan Aizik, Jarmila Sekeresova Kralova, Mor Gross-Vered, Sigalit Boura-Halfon, Tsvee Lapidot, Ronen Alon, Kiavash Movahedi, Steffen Jung
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Expression of the membrane tetraspanin claudin 18 on cancer cells promotes T lymphocyte infiltration and antitumor immunity in pancreatic cancer Immunity (IF 32.4) Pub Date : 2024-05-14 Francesco De Sanctis, Silvia Dusi, Simone Caligola, Cristina Anselmi, Varvara Petrova, Barbara Rossi, Gabriele Angelini, Michael Erdeljan, Stefan Wöll, Anna Melissa Schlitter, Thomas Metzler, Katja Steiger, Zea Borok, Peter Bailey, Aline Bauer, Cornelia Halin, Federico Boschi, Rosalba Giugno, Stefania Canè, Rita Lawlor, Vincenzo Bronte
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Immunity by AS03ation: The natural adjuvantage Immunity (IF 32.4) Pub Date : 2024-05-14 Lena Hansen, Jenna J. Guthmiller
Humans do not respond equally to vaccination. To investigate why, Mulè et al. developed a multimodal framework and found that high responders after unadjuvanted influenza vaccination exist in a naturally adjuvanted state, mimicking innate immunophenotypes following AS03-adjuvanted vaccination. This highlights biological factors that set apart high-antibody responders and how adjuvants can boost innate
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Non-canonical IKKs side with N4BP1 against the family Immunity (IF 32.4) Pub Date : 2024-05-14 Dominic De Nardo
The ubiquitin-binding endoribonuclease N4BP1 is a critical immunosuppressor, but the mechanism by which it acts to constrain TLR-induced inflammatory cytokine production has remained unclear. In this issue of Immunity, Gitlin et al. find that N4BP1 works in concert with the non-canonical IκB kinase (IKK) to limit activity of the IKK complex.
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Hair care: Stem cells control immune response during wound repair Immunity (IF 32.4) Pub Date : 2024-05-14 Shannon McCarthy, Judith Agudo
Stem cells heal wounds. In this issue of Immunity, Luan et al. demonstrate that epidermal stem cells orchestrate the recruitment of regulatory T (Treg) cells and neutrophils during wound healing. Treg cells facilitate a tolerogenic environment to protect epithelial regeneration while neutrophils promote inflammation to ward off infection.
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A new superhero, the intraepithelial mast cell, joins the “Guardians of the Gut” Immunity (IF 32.4) Pub Date : 2024-05-14 Aidil Zaini, Nicola L. Harris
The intestinal epithelium interacts with immune cells to support tissue homeostasis and coordinate responses against pathogens. In this issue of Immunity, Yang et al. unveil a central role for mast cell-epithelial cell interactions in orchestrating protective type 2 immune responses following intestinal helminth infection.
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Astrocytes remember inflammation Immunity (IF 32.4) Pub Date : 2024-05-14 Michael R. Williamson, Benjamin Deneen
Astrocytes respond to all forms of central nervous system maladies. In a recent issue of Nature, Lee et al. demonstrate that astrocytes encode inflammatory stimuli as epigenetic memory, which strengthens responses to subsequent stimuli and exacerbates pathology in disease models.
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Ironing out the role of ferroptosis in immunity Immunity (IF 32.4) Pub Date : 2024-05-14 Hannah N. Bell, Brent R. Stockwell, Weiping Zou
Ferroptosis is a type of regulated cell death that drives the pathophysiology of many diseases. Oxidative stress is detectable in many types of regulated cell death, but only ferroptosis involves lipid peroxidation and iron dependency. Ferroptosis originates and propagates from several organelles, including the mitochondria, endoplasmic reticulum, Golgi, and lysosomes. Recent data have revealed that
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Platelets: Orchestrators of immunity in host defense and beyond Immunity (IF 32.4) Pub Date : 2024-05-14 Leo Nicolai, Kami Pekayvaz, Steffen Massberg
Platelets prevent blood loss during vascular injury and contribute to thrombus formation in cardiovascular disease. Beyond these classical roles, platelets are critical for the host immune response. They guard the vasculature against pathogens via specialized receptors, intracellular signaling cascades, and effector functions. Platelets also skew inflammatory responses by instructing innate immune
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Connecting vitamin D, the microbiome and anticancer immunity Nat. Rev. Immunol. (IF 100.3) Pub Date : 2024-05-14 Alexandra Flemming
Vitamin D has a role in immune modulation and in shaping commensal microbial communities. Reis e Sousa and colleagues show that mice lacking Gc globulin (Gc−/− mice), which regulates vitamin D availability, display enhanced tumour resistance. Intriguingly, co-housed wild-type mice, as well as mice that receive a faecal transfer from Gc−/− mice, also exhibit enhanced tumour immunity. The authors found
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How the brain regulates inflammation Nat. Rev. Immunol. (IF 100.3) Pub Date : 2024-05-14 Alexandra Flemming
Infections can activate neural circuits that mediate responses such as fever and malaise. Jin et al. describe a body-to-brain neural circuit that informs the brain of emerging inflammatory responses. Intraperitoneal injection of mice with lipopolysaccharide (LPS) or other immune insults was shown to activate specific neurons in the caudal nucleus of the solitary tract (cNST) in the brainstem. Genetic
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Time of day determines cancer immunotherapy response Nat. Rev. Immunol. (IF 100.3) Pub Date : 2024-05-14 Alexandra Flemming
Wang et al. show that immune cell infiltration of tumours, as well as immune cell phenotype, oscillate in a circadian manner, which can be harnessed to optimize cancer immunotherapy. In a mouse model of melanoma, the numbers of tumour infiltrating leukocytes (TILs) peaked in the evening, and this was due to fluctuating levels of the adhesion molecule ICAM-1 on endothelial cells. Treatment with chimeric
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Nurture over nature for old antitumor T cells Nat. Immunol. (IF 30.5) Pub Date : 2024-05-14 Justin E. Wilson, Janko Ž. Nikolich
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The aged tumor microenvironment limits T cell control of cancer Nat. Immunol. (IF 30.5) Pub Date : 2024-05-14 Alex C. Y. Chen, Sneha Jaiswal, Daniela Martinez, Cansu Yerinde, Keely Ji, Velita Miranda, Megan E. Fung, Sarah A. Weiss, Maria Zschummel, Kazuhiro Taguchi, Christopher S. Garris, Thorsten R. Mempel, Nir Hacohen, Debattama R. Sen
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Tuft cell-derived acetylcholine promotes epithelial chloride secretion and intestinal helminth clearance Immunity (IF 32.4) Pub Date : 2024-05-13 Tyler E. Billipp, Connie Fung, Lily M. Webeck, Derek B. Sargent, Matthew B. Gologorsky, Zuojia Chen, Margaret M. McDaniel, Darshan N. Kasal, John W. McGinty, Kaitlyn A. Barrow, Lucille M. Rich, Alessio Barilli, Mark Sabat, Jason S. Debley, Chuan Wu, Richard Myers, Michael R. Howitt, Jakob von Moltke
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The RIPK1 death domain restrains ZBP1- and TRIF-mediated cell death and inflammation Immunity (IF 32.4) Pub Date : 2024-05-13 Takashi Imai, Juan Lin, Göksu Gökberk Kaya, Eunjin Ju, Vangelis Kondylis, Konstantinos Kelepouras, Gianmaria Liccardi, Chun Kim, Manolis Pasparakis
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Tuft cell acetylcholine is released into the gut lumen to promote anti-helminth immunity Immunity (IF 32.4) Pub Date : 2024-05-13 Marième Ndjim, Imène Gasmi, Fabien Herbert, Charlène Joséphine, Julie Bas, Ali Lamrani, Nathalie Coutry, Sylvain Henry, Valérie S. Zimmermann, Valérie Dardalhon, Marta Campillo Poveda, Evgenia Turtoi, Steeve Thirard, Luc Forichon, Alicia Giordano, Claire Ciancia, Zeinab Homayed, Julie Pannequin, Collette Britton, Eileen Devaney, Philippe Jay
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Structural transitions enable interleukin-18 maturation and signaling Immunity (IF 32.4) Pub Date : 2024-05-10 Ying Dong, Jeffrey P. Bonin, Pascal Devant, Zhuoyi Liang, Alexander I.M. Sever, Julian Mintseris, James M. Aramini, Gang Du, Stephen P. Gygi, Jonathan C. Kagan, Lewis E. Kay, Hao Wu
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Nucleobase adducts bind MR1 and stimulate MR1-restricted T cells Sci. Immunol (IF 24.8) Pub Date : 2024-05-10 Alessandro Vacchini, Andrew Chancellor, Qinmei Yang, Rodrigo Colombo, Julian Spagnuolo, Giuliano Berloffa, Daniel Joss, Ove Øyås, Chiara Lecchi, Giulia De Simone, Aisha Beshirova, Vladimir Nosi, José Pedro Loureiro, Aurelia Morabito, Corinne De Gregorio, Michael Pfeffer, Verena Schaefer, Gennaro Prota, Alfred Zippelius, Jörg Stelling, Daniel Häussinger, Laura Brunelli, Peter Villalta, Marco Lepore
MR1T cells are a recently found class of T cells that recognize antigens presented by the major histocompatibility complex-I–related molecule MR1 in the absence of microbial infection. The nature of the self-antigens that stimulate MR1T cells remains unclear, hampering our understanding of their physiological role and therapeutic potential. By combining genetic, pharmacological, and biochemical approaches
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A lactate-SREBP2 signaling axis drives tolerogenic dendritic cell maturation and promotes cancer progression Sci. Immunol (IF 24.8) Pub Date : 2024-05-10 Michael P. Plebanek, Yue Xue, Y-Van Nguyen, Nicholas C. DeVito, Xueying Wang, Alisha Holtzhausen, Georgia M. Beasley, Balamayooran Theivanthiran, Brent A. Hanks
Conventional dendritic cells (DCs) are essential mediators of antitumor immunity. As a result, cancers have developed poorly understood mechanisms to render DCs dysfunctional within the tumor microenvironment (TME). After identification of CD63 as a specific surface marker, we demonstrate that mature regulatory DCs (mregDCs) migrate to tumor-draining lymph node tissues and suppress DC antigen cross-presentation
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Single-cell analysis of anti-BCMA CAR T cell therapy in patients with central nervous system autoimmunity Sci. Immunol (IF 24.8) Pub Date : 2024-05-10 Chuan Qin, Min Zhang, Da-Peng Mou, Luo-Qi Zhou, Ming-Hao Dong, Liang Huang, Wen Wang, Song-Bai Cai, Yun-Fan You, Ke Shang, Jun Xiao, Di Wang, Chun-Rui Li, Yi Hao, Michael Heming, Long-Jun Wu, Gerd Meyer Zu Hörste, Chen Dong, Bi-Tao Bu, Dai-Shi Tian, Wei Wang
Chimeric antigen receptor (CAR) T cell immunotherapy for the treatment of neurological autoimmune diseases is promising, but CAR T cell kinetics and immune alterations after treatment are poorly understood. Here, we performed single-cell multi-omics sequencing of paired cerebrospinal fluid (CSF) and blood samples from patients with neuromyelitis optica spectrum disorder (NMOSD) treated with anti–B
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Antigen-level resolution of commensal-specific B cell responses can be enabled by phage display screening coupled with B cell tetramers Immunity (IF 32.4) Pub Date : 2024-05-08 Sheenam Verma, Matthew J. Dufort, Tayla M. Olsen, Samantha Kimmel, Jasmine C. Labuda, Sam Scharffenberger, Andrew T. McGuire, Oliver J. Harrison
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Protect the periportals Nat. Rev. Immunol. (IF 100.3) Pub Date : 2024-05-08 Yvonne Bordon
Commensal bacteria induce liver macrophages that protect the tissue against inflammation.
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Atypical chemokine receptors in the immune system Nat. Rev. Immunol. (IF 100.3) Pub Date : 2024-05-07 Iain Comerford, Shaun R. McColl
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Oxidative phosphorylation regulates B cell effector cytokines and promotes inflammation in multiple sclerosis Sci. Immunol (IF 24.8) Pub Date : 2024-05-03 Rui Li, Yanting Lei, Ayman Rezk, Diego A. Espinoza, Jing Wang, Huiru Feng, Bo Zhang, Isabella P. Barcelos, Hang Zhang, Jing Yu, Xinrui Huo, Fangyi Zhu, Changxin Yang, Hao Tang, Amy C. Goldstein, Brenda L. Banwell, Hakon Hakonarson, Hongwei Xu, Michael Mingueneau, Bo Sun, Hulun Li, Amit Bar-Or
Dysregulated B cell cytokine production contributes to pathogenesis of immune-mediated diseases including multiple sclerosis (MS); however, the underlying mechanisms are poorly understood. In this study we investigated how cytokine secretion by pro-inflammatory (GM-CSF–expressing) and anti-inflammatory (IL-10–expressing) B cells is regulated. Pro-inflammatory human B cells required increased oxidative
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Defining the balance between optimal immunity and immunopathology in influenza virus infection Nat. Rev. Immunol. (IF 100.3) Pub Date : 2024-05-02 Thi H. O. Nguyen, Louise C. Rowntree, Brendon Y. Chua, Ryan S. Thwaites, Katherine Kedzierska
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Glucose-driven histone lactylation promotes the immunosuppressive activity of monocyte-derived macrophages in glioblastoma Immunity (IF 32.4) Pub Date : 2024-05-03 Alessandra De Leo, Alessio Ugolini, Xiaoqing Yu, Fabio Scirocchi, Delia Scocozza, Barbara Peixoto, Angelica Pace, Luca D’Angelo, James K.C. Liu, Arnold B. Etame, Aurelia Rughetti, Marianna Nuti, Antonio Santoro, Michael A. Vogelbaum, Jose R. Conejo-Garcia, Paulo C. Rodriguez, Filippo Veglia
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The immunoglobulin superfamily ligand B7H6 subjects T cell responses to NK cell surveillance Sci. Immunol (IF 24.8) Pub Date : 2024-05-03 Michael Kilian, Mirco J. Friedrich, Kevin Hai-Ning Lu, David Vonhören, Selina Jansky, Julius Michel, Anna Keib, Saskia Stange, Nicolaj Hackert, Niklas Kehl, Markus Hahn, Antje Habel, Stefanie Jung, Kristine Jähne, Felix Sahm, Johannes Betge, Adelheid Cerwenka, Frank Westermann, Peter Dreger, Marc S. Raab, Nadja M. Meindl-Beinker, Matthias Ebert, Lukas Bunse, Carsten Müller-Tidow, Michael Schmitt, Michael
Understanding the mechanisms that regulate T cell immunity is critical for the development of effective therapies for diseases associated with T cell dysfunction, including autoimmune diseases, chronic infections, and cancer. Co-inhibitory “checkpoint molecules,” such as programmed cell death protein-1, balance excessive or prolonged immune activation by T cell–intrinsic signaling. Here, by screening
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A T H 17-intrinsic IL-1β–STAT5 axis drives steroid resistance in autoimmune neuroinflammation Sci. Immunol (IF 24.8) Pub Date : 2024-05-03 William A. Miller-Little, Xing Chen, Vanessa Salazar, Caini Liu, Katarzyna Bulek, Julie Y. Zhou, Xiao Li, Olaf Stüve, Thaddeus Stappenbeck, George Dubyak, Junjie Zhao, Xiaoxia Li
Steroid resistance poses a major challenge for the management of autoimmune neuroinflammation. T helper 17 (T H 17) cells are widely implicated in the pathology of steroid resistance; however, the underlying mechanisms are unknown. In this study, we identified that interleukin-1 receptor (IL-1R) blockade rendered experimental autoimmune encephalomyelitis (EAE) mice sensitive to dexamethasone (Dex)
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The Benjamin Button effect on stem cells: Reversing the clock on aging immunity Sci. Immunol (IF 24.8) Pub Date : 2024-05-03 Luciana Conde, Carolina Lucas
Antibody-based therapy depletes myeloid-biased hematopoietic stem cells (my-HSCs) to rejuvenate the immune system and improve immune responses in aged mice.
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Opportunities and challenges for T cell-based influenza vaccines Nat. Rev. Immunol. (IF 100.3) Pub Date : 2024-05-02 Tim R. Mosmann, Andrew J. McMichael, Alexandre LeVert, John W. McCauley, Jeffrey W. Almond
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Keeping neonatal intestines happy Nat. Immunol. (IF 30.5) Pub Date : 2024-05-02 Stephanie Houston
Serotonin (also known as 5-hydroxytryptamine or 5-HT) controls gut motility, platelet function, mood regulation and has been implicated in inflammatory bowel disease, but its role in the neonatal gut is unclear. In Science Immunology, Sanidad et al. find that 5-HT derived from the microbiota promotes the differentiation of regulatory T (Treg) cells and confers tolerance to dietary antigens and commensal
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Inflammatory fibroblasts remodeling in colitis Nat. Immunol. (IF 30.5) Pub Date : 2024-05-02 Paula Jauregui
Inflammatory bowel diseases (IBDs) are characterized by waves of relapse and remitting inflammation that lead to the remodeling of the cellular diversity of the gut. In Cell, Paolo Cadinu at al. chart the cellular and spatial structures of the colon in a mouse model of IBD. Using an image-based approach to spatial transcriptomics that can capture thousands of RNA molecules within single cells in their
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New role for TLR9 Nat. Immunol. (IF 30.5) Pub Date : 2024-05-02 Laurie A. Dempsey
Toll-like receptor 9 (TLR9) is an innate immune sensor that recognizes intracellular double-stranded DNA (dsDNA). In Nature, Jovasevic et al. show that TLR9–NF-κB signaling in specific hippocampal neurons is required for the generation of learning-induced memory formation in mice. Using models of contextual fear conditioning (CFC), the authors show that nuclear non-coding dsDNA fragments appear within
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Predictability of B cell clonal persistence and immunosurveillance in breast cancer Nat. Immunol. (IF 30.5) Pub Date : 2024-05-02 Stephen-John Sammut, Jacob D. Galson, Ralph Minter, Bo Sun, Suet-Feung Chin, Leticia De Mattos-Arruda, Donna K. Finch, Sebastian Schätzle, Jorge Dias, Oscar M. Rueda, Joan Seoane, Jane Osbourn, Carlos Caldas, Rachael J. M. Bashford-Rogers
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Coordinated chemokine expression defines macrophage subsets across tissues Nat. Immunol. (IF 30.5) Pub Date : 2024-05-02 Xin Li, Arlind B. Mara, Shawn C. Musial, Fred W. Kolling, Sophie L. Gibbings, Nikita Gerebtsov, Claudia V. Jakubzick
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Temporal dynamics and genomic programming of plasma cell fates Nat. Immunol. (IF 30.5) Pub Date : 2024-05-02 Godhev Kumar Manakkat Vijay, Ming Zhou, Kairavee Thakkar, Abigail Rothrauff, Amanpreet Singh Chawla, Dianyu Chen, Louis Chi-Wai Lau, Peter Habib Gerges, Kashish Chetal, Prabal Chhibbar, Jingyu Fan, Jishnu Das, Alok Joglekar, Lisa Borghesi, Nathan Salomonis, Heping Xu, Harinder Singh
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The ouroboros of autoimmunity Nat. Immunol. (IF 30.5) Pub Date : 2024-05-02 Jean-Laurent Casanova, Jessica Peel, Jean Donadieu, Anna-Lena Neehus, Anne Puel, Paul Bastard
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Lysosomal endonuclease RNase T2 and PLD exonucleases cooperatively generate RNA ligands for TLR7 activation Immunity (IF 32.4) Pub Date : 2024-05-01 Marleen Bérouti, Katja Lammens, Matthias Heiss, Larissa Hansbauer, Stefan Bauernfried, Jan Stöckl, Francesca Pinci, Ignazio Piseddu, Wilhelm Greulich, Meiyue Wang, Christophe Jung, Thomas Fröhlich, Thomas Carell, Karl-Peter Hopfner, Veit Hornung
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Integrating population and single-cell variations in vaccine responses identifies a naturally adjuvanted human immune setpoint Immunity (IF 32.4) Pub Date : 2024-05-01 Matthew P. Mulè, Andrew J. Martins, Foo Cheung, Rohit Farmer, Brian A. Sellers, Juan A. Quiel, Arjun Jain, Yuri Kotliarov, Neha Bansal, Jinguo Chen, Pamela L. Schwartzberg, John S. Tsang
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N4BP1 coordinates ubiquitin-dependent crosstalk within the IκB kinase family to limit Toll-like receptor signaling and inflammation Immunity (IF 32.4) Pub Date : 2024-05-01 Alexander D. Gitlin, Allie Maltzman, Yuzuka Kanno, Klaus Heger, Rohit Reja, Alexander F. Schubert, Linsey J. Wierciszewski, Homer Pantua, Sharookh B. Kapadia, Seth F. Harris, Joshua D. Webster, Kim Newton, Vishva M. Dixit
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A CTCF-binding site in the Mdm1-Il22-Ifng locus shapes cytokine expression profiles and plays a critical role in early Th1 cell fate specification Immunity (IF 32.4) Pub Date : 2024-05-01 Chunhong Liu, Hiroyuki Nagashima, Nilisha Fernando, Victor Bass, Jaanam Gopalakrishnan, Sadie Signorella, Will Montgomery, Ai Ing Lim, Oliver Harrison, Lauren Reich, Chen Yao, Hong-Wei Sun, Stephen R. Brooks, Kan Jiang, Vijayaraj Nagarajan, Yongbing Zhao, Seolkyoung Jung, Rachael Phillips, Yohei Mikami, Caleb A. Lareau, Han-Yu Shih
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Adipose-tissue Treg cells restrain differentiation of stromal adipocyte precursors to promote insulin sensitivity and metabolic homeostasis Immunity (IF 32.4) Pub Date : 2024-04-30 Gang Wang, Andrés R. Muñoz-Rojas, Raul German Spallanzani, Ruth A. Franklin, Christophe Benoist, Diane Mathis
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DAMP sensing and sterile inflammation: intracellular, intercellular and inter-organ pathways Nat. Rev. Immunol. (IF 100.3) Pub Date : 2024-04-29 Yi Huang, Wei Jiang, Rongbin Zhou
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Baseline JAK–STAT signaling maintains immune cell homeostasis Nat. Immunol. (IF 30.5) Pub Date : 2024-04-29
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Human SHARPIN deficiency is linked to inborn errors of cell death Nat. Immunol. (IF 30.5) Pub Date : 2024-04-29
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Sepsis-trained macrophages promote antitumoral tissue-resident T cells Nat. Immunol. (IF 30.5) Pub Date : 2024-04-29 Alexis Broquet, Victor Gourain, Thomas Goronflot, Virginie Le Mabecque, Debajyoti Sinha, Mitra Ashayeripanah, Cédric Jacqueline, Pierre Martin, Marion Davieau, Lea Boutin, Cecile Poulain, Florian P. Martin, Cynthia Fourgeux, Melanie Petrier, Manon Cannevet, Thomas Leclercq, Maeva Guillonneau, Tanguy Chaumette, Thomas Laurent, Christelle Harly, Emmanuel Scotet, Laurent Legentil, Vincent Ferrières, Stephanie
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Noncanonical inflammasome mediates BBB breakdown Nat. Rev. Immunol. (IF 100.3) Pub Date : 2024-04-26 Kirsty Minton
Wei et al. report a role for membrane perforation mediated by gasdermin D pores in disruption of the blood–brain barrier.
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FAS signalling pathway is crucial for CAR T cell persistence Nat. Rev. Immunol. (IF 100.3) Pub Date : 2024-04-26 Robyn Loves, Eyal Grunebaum
A preprint by Yi et al. shows a role for the FAS signalling pathway in controlling the persistence of CAR-modified lymphocytes.
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Transient synaptic CD61 pairing with CD103 increases the cytotoxicity of antigen-specific T cells Nat. Immunol. (IF 30.5) Pub Date : 2024-04-26
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Apolipoprotein E controls Dectin-1-dependent development of monocyte-derived alveolar macrophages upon pulmonary β-glucan-induced inflammatory adaptation Nat. Immunol. (IF 30.5) Pub Date : 2024-04-26 H. Theobald, D. A. Bejarano, N. Katzmarski, J. Haub, J. Schulte-Schrepping, J. Yu, K. Bassler, A. L. Ament, C. Osei-Sarpong, F. Piattini, L. Vornholz, W. T’Jonck, A. H. Györfi, H. Hayer, X. Yu, S. Sheoran, A. Al Jawazneh, S. Chakarov, K. Haendler, G. D. Brown, D. L. Williams, L. Bosurgi, J. H. W. Distler, F. Ginhoux, J. Ruland, M. D. Beyer, M. Greter, C. C. Bain, A. I. Vazquez-Armendariz, M. Kopf,
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Transcription factor Tox2 is required for metabolic adaptation and tissue residency of ILC3 in the gut Immunity (IF 32.4) Pub Date : 2024-04-26 Arundhoti Das, Gustavo Ulises Martinez-Ruiz, Nicolas Bouladoux, Apollo Stacy, Josquin Moraly, Maria Vega-Sendino, Yongge Zhao, Marieke Lavaert, Yi Ding, Abigail Morales-Sanchez, Christelle Harly, Mina O. Seedhom, Raj Chari, Parirokh Awasthi, Tomoko Ikeuchi, Yueqiang Wang, Jinfang Zhu, Niki M. Moutsopoulos, WanJun Chen, Jonathan W. Yewdell, Avinash Bhandoola
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CD80 on skin stem cells promotes local expansion of regulatory T cells upon injury to orchestrate repair within an inflammatory environment Immunity (IF 32.4) Pub Date : 2024-04-26 Jingyun Luan, Cynthia Truong, Aleksandra Vuchkovska, Weijie Guo, Jennifer Good, Bijun Liu, Audrey Gang, Nicole Infarinato, Katherine Stewart, Lisa Polak, Hilda Amalia Pasolli, Emma Andretta, Alexander Y. Rudensky, Elaine Fuchs, Yuxuan Miao
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Up-regulated PLA2G10 in cancer impairs T cell infiltration to dampen immunity Sci. Immunol (IF 24.8) Pub Date : 2024-04-26 Tianxiang Zhang, Weiwei Yu, Xiaoxiao Cheng, Jacky Yeung, Viviana Ahumada, Paul C. Norris, Mackenzie J. Pearson, Xuan Yang, Willemijn van Deursen, Christina Halcovich, Ala Nassar, Mathew D. Vesely, Yu Zhang, Jianping Zhang, Lan Ji, Dallas B. Flies, Linda Liu, Solomon Langermann, William J. LaRochelle, Rachel Humphrey, Dejian Zhao, Qiuyu Zhang, Jindong Zhang, Runxia Gu, Kurt A. Schalper, Miguel F. Sanmamed
T cells are often absent from human cancer tissues during both spontaneously induced immunity and therapeutic immunotherapy, even in the presence of a functional T cell–recruiting chemokine system, suggesting the existence of T cell exclusion mechanisms that impair infiltration. Using a genome-wide in vitro screening platform, we identified a role for phospholipase A2 group 10 (PLA2G10) protein in
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Targeted depletion of PD-1–expressing cells induces immune tolerance through peripheral clonal deletion Sci. Immunol (IF 24.8) Pub Date : 2024-04-26 Jikai Cui, Heng Xu, Jizhang Yu, Shuan Ran, Xi Zhang, Yuan Li, Zhang Chen, Yuqing Niu, Song Wang, Weicong Ye, Wenhao Chen, Jie Wu, Jiahong Xia
Thymic negative selection of the T cell receptor (TCR) repertoire is essential for establishing self-tolerance and acquired allograft tolerance following organ transplantation. However, it is unclear whether and how peripheral clonal deletion of alloreactive T cells induces transplantation tolerance. Here, we establish that programmed cell death protein 1 (PD-1) is a hallmark of alloreactive T cells
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A microbial iron fist to fight tumors Nat. Immunol. (IF 30.5) Pub Date : 2024-04-25 Samuel P. Nobs, Eran Elinav
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A dietary commensal microbe enhances antitumor immunity by activating tumor macrophages to sequester iron Nat. Immunol. (IF 30.5) Pub Date : 2024-04-25 Garima Sharma, Amit Sharma, Inhae Kim, Dong Gon Cha, Somi Kim, Eun Seo Park, Jae Gyun Noh, Juhee Lee, Ja Hyeon Ku, Yoon Ha Choi, JungHo Kong, Haena Lee, Haeun Ko, Juhun Lee, Anna Notaro, Seol Hee Hong, Joon Haeng Rhee, Sang Geon Kim, Cristina De Castro, Antonio Molinaro, Kunyoo Shin, Sanguk Kim, Jong Kyoung Kim, Dipayan Rudra, Sin-Hyeog Im
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Eliciting a single amino acid change by vaccination generates antibody protection against group 1 and group 2 influenza A viruses Immunity (IF 32.4) Pub Date : 2024-04-25 Rashmi Ray, Faez Amokrane Nait Mohamed, Daniel P. Maurer, Jiachen Huang, Berk A. Alpay, Larance Ronsard, Zhenfei Xie, Julianna Han, Monica Fernandez-Quintero, Quynh Anh Phan, Rebecca L. Ursin, Mya Vu, Kathrin H. Kirsch, Thavaleak Prum, Victoria C. Rosado, Thalia Bracamonte-Moreno, Vintus Okonkwo, Julia Bals, Caitlin McCarthy, Usha Nair, Daniel Lingwood
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Harnessing our lived experience for science communication Nat. Rev. Immunol. (IF 100.3) Pub Date : 2024-04-24 Adrian Liston
Adrian Liston, professor of pathology at the University of Cambridge, UK, has published several illustrated children’s books on the topic of vaccination and has developed a computer game called ‘VirusFighter’. Here, he shares his thoughts on how to become an effective science communicator.