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Settling with the motion Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2025-02-17 Andrea Du Toit
This study reports two different mechanisms that enable bacterial surface colonization under high flow conditions.
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Self-sacrificing cell death to thwart phage infection Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2025-02-13 Andrea Du Toit
This study describes the bacterial type IV Thoeris defence system, which contains both a Toll/interleukin-1 receptor (TIR) domain protein and a caspase-like protease.
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The intruders that stole the master key Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2025-02-11 Miguel F. Romero
This Genome Watch article highlights how genomics and different experimental approaches reveal how intracellular bacteria control key processes of their hosts.
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RNA evolution shapes SARS-CoV-2 success Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2025-02-10 Agustina Taglialegna
In this study, Mears et al. show that SARS-CoV-2 can evolve not only through protein changes but also through functional RNA adaptations to increase fitness and immune evasion.
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A gut microbiome-restoring diet Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2025-02-10 Agustina Taglialegna
In this study, Li et al. perform a randomized controlled feeding trial to test the effects of a microbiome restoration strategy on gut microbiome features, host physiology and health.
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Fungal biofilms in human health and disease Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2025-02-05 Gordon Ramage, Ryan Kean, Riina Rautemaa-Richardson, Craig Williams, Jose L. Lopez-Ribot
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Mining microbiomes for microproteins Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2025-01-30 B. Anne Neville, Trevor D. Lawley
This Genome Watch discusses strategies to detect small open reading frames and study microproteins encoded in microbiomes to understand their diversity and functions across microorganisms.
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Overcoming research challenges in resource-limited settings: perspectives from Thailand Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2025-01-28 Claire Chewapreecha, Thongchai Chewprecha
This Comment highlights the challenges and rewards of researchers working in resource-limited settings, specifically Thailand, and provides potential solutions to help Thai researchers overcome these difficulties.
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Bacterial contact killing Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2025-01-27 Andrea Du Toit
This study reports that bacteria protect plants against filamentous fungal infections via intercellular contacts between the bacterial cells and the conidia of the fungi.
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A kill switch for tuberculosis Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2025-01-27 Agustina Taglialegna
In two recent studies, Smith, Su, Wallach et al. engineered a safer version of Bacille Calmette–Guerin with strong protection against Mycobacterium tuberculosis, while Wang, Su, Wallach, Wagner et al. developed an engineered M. tuberculosis strain as a candidate for human challenge studies.
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Stopping Marburg virus in its tracks Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2025-01-24 Agustina Taglialegna
In this study, Cross, Woolsey, Prasad et al. report obeldesivir as a promising post-exposure prophylaxis for filoviruses.
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Opposing forces Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2025-01-22 Andrea Du Toit
This study shows that metabolites from both an infecting pathogen and the gut microbiota of the host are major determinants of survival from bacterial sepsis in mice.
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Microbial interactions lead to ecosystem function Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2025-01-22 Flora Vincent
In this Journal Club, Flora Vincent revisits a paper that summarized the ecological roles of microorganisms in the ocean ecosystem and that greatly impacted the field of marine microbiology.
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Norovirus replication, host interactions and vaccine advances Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2025-01-17 B. V. Venkataram Prasad, Robert L. Atmar, Sasirekha Ramani, Timothy Palzkill, Yongcheng Song, Sue E. Crawford, Mary K. Estes
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Microbial secondary metabolites: advancements to accelerate discovery towards application Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2025-01-17 Jaime Lorenzo N. Dinglasan, Hiroshi Otani, Drew T. Doering, Daniel Udwary, Nigel J. Mouncey
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Microbiota–neuroepithelial signalling across the gut–brain axis Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2025-01-02 Takahiro E. Ohara, Elaine Y. Hsiao
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Taking the jump to humans Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-12-23 Ashley York
In a recent study, Lin et al. uncovered that a single substitution in the bovine influenza H5N1 haemagglutinin protein switches the specificity to human receptors.
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Responding to extreme climates Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-12-19 Ashley York
A recent study found that soil microbial communities show consistent and predictable responses to extreme climatic events.
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Author Correction: Examining the healthy human microbiome concept Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-12-16 Raphaela Joos, Katy Boucher, Aonghus Lavelle, Manimozhiyan Arumugam, Martin J. Blaser, Marcus J. Claesson, Gerard Clarke, Paul D. Cotter, Luisa De Sordi, Maria G. Dominguez-Bello, Bas E. Dutilh, Stanislav D. Ehrlich, Tarini Shankar Ghosh, Colin Hill, Christophe Junot, Leo Lahti, Trevor D. Lawley, Tine R. Licht, Emmanuelle Maguin, Thulani P. Makhalanyane, Julian R. Marchesi, Jelle Matthijnssens, Jeroen
Correction to: Nature Reviews Microbiology https://doi.org/10.1038/s41579-024-01107-0, published online 23 October 2024
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Commensals find their niche Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-12-16 Andrea Du Toit
A recent study shows that the commensal bacterium Lactiplantibacillus plantarum recognizes the foregut of the fruit fly as its physical niche via sugar-binding adhesins.
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Gut phages fuel food addiction Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-12-11 Agustina Taglialegna
In this study, Castells-Nobau et al. show that bacteriophages present in the gut microbiome contribute to the regulation of food addiction.
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Linking innate immune evasion to pandemic potential Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-12-11 Lucy G. Thorne
In this journal club, Lucy Thorne discusses a paper that compares pandemic and non-pandemic HIV and shows that the ability of pandemic HIV to effectively evade the host’s innate immune response is a key factor in its pandemic potential.
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Campylobacter spreads colorectal cancer Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-12-09 Andrea Du Toit
This study shows that the Campylobacter jejuni-derived genotoxin named cytolethal distending toxin promotes colorectal cancer metastasis.
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Metagenomics for drug discovery Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-12-05 Agustina Taglialegna
In this study, Padhi et al. demonstrate the potential of metagenomics-based approaches for the discovery of natural products from complex ecosystems.
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Methanogens implicated by DNA evidence Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-11-27 Matthew Kellom
This Genome Watch article highlights recent findings that expand the known diversity of methanogenic archaea and the metagenomic evidence that led to their identification and cultivation.
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Shigella sonnei: epidemiology, evolution, pathogenesis, resistance and host interactions Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-11-27 Timothy A. Scott, Kate S. Baker, Caroline Trotter, Claire Jenkins, Serge Mostowy, Jane Hawkey, Hayden Schmidt, Kathryn E. Holt, Nicholas R. Thomson, Stephen Baker
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The consequences of SARS-CoV-2 within-host persistence Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-11-25 Alex Sigal, Richard A. Neher, Richard J. Lessells
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Hepatitis B and D virus entry Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-11-21 Koichi Watashi, Kaho Shionoya, Chisa Kobayashi, Takeshi Morita
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Predicting phage–host specificity Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-11-19 Ashley York
In a recent study, Gaborieau, Vaysset, Tesson et al. developed a method to predict phage–host specificity using genomic data.
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Designer viral receptors Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-11-19 Ashley York
In a recent study, Liu, Huang, Guo, McCallum et al. present a method to create functional, customized coronavirus receptors, which could facilitate the development of infection models that do not rely on native receptors.
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Iron gatekeeper in malaria Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-11-19 Ashley York
Loveridge and Sigala uncover a divalent metal transporter that is required for cellular iron metabolism in Plasmodium falciparum parasites.
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Gut microbiota clocks in stress Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-11-18 Agustina Taglialegna
In this study, Tofani et al. demonstrate that the gut microbiota regulates stress responsiveness in mice via the circadian system.
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Waning resistance Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-11-18 Andrea Du Toit
This study provides insights into how adaptive changes in evolved microbial communities can affect pathogen invasion.
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Antibiotic-recalcitrant Salmonella during infection Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-11-18 Rachel T. Giorgio, Sophie Helaine
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A mimic targets intracellular Staphylococcus aureus Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-11-14 Agustina Taglialegna
In this study, Ge et al. develop a mimic of natural killer cells to target and eliminate intracellular Staphylococcus aureus.
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A river of resistant genes uncovered by metagenomics Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-11-14 Onalenna Neo, Nisha Singh, Adrian Cazares
This Genome Watch discusses the use of metagenomic sequencing to investigate resistome dynamics in river ecosystems and their associations with the mobilome and microbiome, underscoring the role of rivers as reservoirs of antimicrobial resistance genes.
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Gender justice and prioritizing women and girls in the HIV response Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-11-14 Nazneen Damji, Lillian Mworeko
A strategic dialogue on ‘gender justice in the HIV response’ held at the 25th International AIDS Conference highlighted how bias and discrimination against women and girls in all their diversities disadvantages them in the HIV response. Ending AIDS requires increased participation and leadership by diverse women at all levels of the HIV response.
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In tandem towards resistance Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-11-13 Andrea Du Toit
This study shows that high-level resistance in methicillin-resistant Staphylococcus aureus involves an alternative mode of cell division.
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Microbial solutions must be deployed against climate catastrophe Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-11-11 Raquel Peixoto, Christian R. Voolstra, Lisa Y. Stein, Philip Hugenholtz, Joana Falcao Salles, Shady A. Amin, Max Häggblom, Ann Gregory, Thulani P. Makhalanyane, Fengping Wang, Nadège Adoukè Agbodjato, Yinzhao Wang, Nianzhi Jiao, Jay T. Lennon, Antonio Ventosa, Patrik M. Bavoil, Virginia Miller, Jack A. Gilbert
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The microbial phosphorus cycle in aquatic ecosystems Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-11-11 Solange Duhamel
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Streptococcus pneumoniae epidemiology, pathogenesis and control Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-11-06 Ana Rita Narciso, Rebecca Dookie, Priyanka Nannapaneni, Staffan Normark, Birgitta Henriques-Normark
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Microbiome-colonizing RNAs Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-10-30 Andrea Du Toit
This study describes the discovery of a previously uncharacterized phylogenetically distinct group of viroid-like human microbiome-associated RNAs.
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Anti-defence islands in plasmids Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-10-23 Andrea Du Toit
This new study shows that the leading region of plasmids has a key role in overcoming host immunity by functioning as ‘anti-defence islands’ that protect the invading plasmid following entry.
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Examining the healthy human microbiome concept Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-10-23 Raphaela Joos, Katy Boucher, Aonghus Lavelle, Manimozhiyan Arumugam, Martin J. Blaser, Marcus J. Claesson, Gerard Clarke, Paul D. Cotter, Luisa De Sordi, Maria G. Dominguez-Bello, Bas E. Dutilh, Stanislav D. Ehrlich, Tarini Shankar Ghosh, Colin Hill, Christophe Junot, Leo Lahti, Trevor D. Lawley, Tine R. Licht, Emmanuelle Maguin, Thulani P. Makhalanyane, Julian R. Marchesi, Jelle Matthijnssens, Jeroen
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Harnessing symbiotic bacteria for disease control Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-10-21 Abraham Morales-Cruz, Leo A. Baumgart
This Genome Watch explores recent transcriptomic and metatranscriptomic analyses that revealed the key role of secondary endosymbionts in host immunity and disease transmission within their insect or plant hosts.
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Diversity and ecology of microbial sulfur metabolism Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-10-17 Zhichao Zhou, Patricia Q. Tran, Elise S. Cowley, Elizabeth Trembath-Reichert, Karthik Anantharaman
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Bloodstream infections: mechanisms of pathogenesis and opportunities for intervention Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-10-17 Caitlyn L. Holmes, Owen R. Albin, Harry L. T. Mobley, Michael A. Bachman
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A gut bacterium trims mucosal immunity Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-10-15 Agustina Taglialegna
In this study, Lu et al. identify the gut symbiont Tomasiella immunophila as a contributor to the degradation of murine secretory immunoglobulin A, with effects on mucosal immunity.
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Re-emergence of Oropouche virus Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-10-15 Agustina Taglialegna
The recent re-emergence of Oropouche virus in Central and South America and the Caribbean poses a public health threat and highlights the need for improved surveillance and control measures.
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Anthropogenic impacts on the terrestrial subsurface biosphere Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-10-15 Kaela K. Amundson, Mikayla A. Borton, Michael J. Wilkins
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Akkermansia muciniphila: biology, microbial ecology, host interactions and therapeutic potential Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-10-15 Athanasia Ioannou, Maryse D. Berkhout, Sharon Y. Geerlings, Clara Belzer
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The gut microbiome and dietary fibres: implications in obesity, cardiometabolic diseases and cancer Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-10-10 Nathalie M. Delzenne, Laure B. Bindels, Audrey M. Neyrinck, Jens Walter
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Bacterial small molecule metabolites implicated in gastrointestinal cancer development Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-10-07 Tayah Turocy, Jason M. Crawford
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Towards next-generation treatment options to combat Plasmodium falciparum malaria Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-10-04 John Okombo, David A. Fidock
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Microbial extracellular polymeric substances in the environment, technology and medicine Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-09-27 Hans-Curt Flemming, Eric D. van Hullebusch, Brenda J. Little, Thomas R. Neu, Per H. Nielsen, Thomas Seviour, Paul Stoodley, Jost Wingender, Stefan Wuertz
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Publisher Correction: Microorganisms, climate change, and the Sustainable Development Goals: progress and challenges Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-09-20 Janet K. Jansson
Correction to: Nature Reviews Microbiology https://doi.org/10.1038/s41579-023-00953-8, published online 27 July 2023.
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The rising mpox crisis Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-09-20 Agustina Taglialegna
An increasing number of countries in Africa are reporting cases of mpox, prompting the World Health Organization to declare it a public health emergency of international concern.
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ISME19 Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-09-20 Agustina Taglialegna
Nature Reviews Microbiology attended the 19th biennial meeting of the International Society for Microbial Ecology (ISME) in Cape Town, South Africa.
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Publisher Correction: Unveiling plasmid diversity in nature Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-09-19 Antonio Pedro Camargo
Correction to: Nature Reviews Microbiology https://doi.org/10.1038/s41579-024-01093-3, published online 28 August 2024.
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Challenges and strategies for addressing antibacterial drug resistance in LMICs Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-09-13 Ursula Theuretzbacher
Antibacterial drug resistance is a critical global health issue that affects countries across all economic levels, though it disproportionately affects populations in low- and middle-income countries. Infection and resistance rates vary considerably, necessitating tailored interventions to meet the specific demands of each area. This underscores the need for global solidarity and national accountability