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Core phylotypes enhance the resistance of soil microbiome to environmental changes to maintain multifunctionality in agricultural ecosystems Glob. Change Biol. (IF 13.211) Pub Date : 2022-08-13 Shuo Jiao, Jiejun Qi, Chujie Jin, Yu Liu, Yang Wang, Haibo Pan, Shi Chen, Chunling Liang, Ziheng Peng, Beibei Chen, Xun Qian, Gehong Wei
Agricultural ecosystems are facing increasing environmental changes. Revealing ecological stability of belowground organisms is key to developing management strategies that maintain agricultural ecosystem services in a changing world. Here, we collected soils from adjacent pairs of maize and rice fields along large spatial scale across Eastern and Southeast China to investigate the importance of core
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Geographic range size, water temperature and extrinsic threats predict the extinction risk in global cetaceans Glob. Change Biol. (IF 13.211) Pub Date : 2022-08-12 Chuanwu Chen, Thomas A. Jefferson, Bingyao Chen, Yanping Wang
Despite that cetaceans provide significant ecological contributions to the health and stability of aquatic ecosystems, they are highly endangered with nearly one-third of species assessed as threatened with extinction. Nevertheless, to date, few studies have explicitly examined the patterns and processes of extinction risk and threats for this taxon, and even less between the two subclades (Mysticeti
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Raman studies of the adipose tissue: Current state-of-art and future perspectives in diagnostics Prog. Lipid. Res. (IF 14.673) Pub Date : 2022-08-09 Krzysztof Czamara, Zuzanna Majka, Ewa Stanek, Natalia Hachlica, Agnieszka Kaczor
The last decades revealed that the adipose tissue shows an unexplored therapeutic potential. In particular, targeting the perivascular adipose tissue (PVAT), that surrounds blood vessels, can prevent cardiovascular pathologies and browning of the adipose tissue can become an effective strategy against obesity. Therefore, new analytical tools are necessary to analyze this tissue. This review reports
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Macrophage SAMSN1 protects against sepsis-induced acute lung injury in mice Redox Biol. (IF 10.787) Pub Date : 2022-08-13 Wanli Jiang, Chengtai Ma, Jiawei Bai, Xianjin Du
Objective Inflammation and oxidative stress contribute to the progression of sepsis-induced acute lung injury (ALI). SAM domain, SH3 domain and nuclear localization signals 1 (SAMSN1) is a signaling adaptor protein, and mainly regulates inflammatory response of various immune cells. The present study generates macrophage-specific SAMSN1-knockout (Samsn1MKO) and SAMSN1-transgenic (Samsn1MTG) mice to
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CXCL1-CXCR2 signalling mediates hypertensive retinopathy by inducing macrophage infiltration Redox Biol. (IF 10.787) Pub Date : 2022-08-13 Shuai Wang, Jie Bai, Yun-Long Zhang, Qiu-Yue Lin, Xiao Han, Wei-Kun Qu, Peng-Fei Zhang, Yu-Song Ge, Qi-Zhao, Hui-Hua Li
Inflammation plays an important role in hypertensive retinal vascular injury and subsequent retinopathy. Monocyte chemotaxis via CXCL1-CXCR2 binding has been implicated in various cardiovascular diseases, but the function of CXCL1-CXCR2 signalling involved in retinopathy, which was investigated as angiotensin II (Ang II)-induced retinopathy, is unclear. In our study, we established a hypertensive retinopathy
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Accuracy, realism and general applicability of European forest models Glob. Change Biol. (IF 13.211) Pub Date : 2022-08-12 M. Mahnken, M. Cailleret, A. Collalti, C. Trotta, C. Biondo, E. D’Andrea, D. Dalmonech, G. Marano, A. Mäkelä, F. Minunno, M. Peltoniemi, V. Trotsiuk, D. Nadal-Sala, S. Sabaté, P. Vallet, R. Aussenac, D. R. Cameron, F. J. Bohn, R. Grote, A. L. D. Augustynczik, R. Yousefpour, N. Huber, H. Bugmann, K. Merganicova, J. Merganic, P. Valent, P. Lasch-Born, F. Hartig, I. D. Vega del Valle, J. Volkholz, M.
Forest models are instrumental for understanding and projecting the impact of climate change on forests. A considerable number of forest models have been developed in the last decades. However, few systematic and comprehensive model comparisons have been performed in Europe that combine an evaluation of modelled carbon and water fluxes and forest structure. We evaluate 13 widely-used, state-of-the-art
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Corrigendum Glob. Change Biol. (IF 13.211) Pub Date : 2022-08-11
The article entitled “The role of climate in past forest loss in an ecologically important region of South Asia” which published in Global Change Biology (Volume 28, Issue 12, pages 3883–3901) has since been updated. The authors have corrected references to India in the title and throughout the article so that the work does not depict any national boundaries in disputed territories, Jammu, Kashmir
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Evolutionary and structural analyses of the NADPH oxidase family in eukaryotes reveal an initial calcium dependency Redox Biol. (IF 10.787) Pub Date : 2022-08-12 Marta Massari, Callum R. Nicoll, Sara Marchese, Andrea Mattevi, Maria Laura Mascotti
Reactive oxygen species (ROS) are unstable molecules generated by the partial reduction of dioxygen. NADPH oxidases are a ubiquitous family of enzymes devoted to ROS production. They fuel an array of physiological roles in different species and are chemically demanding enzymes requiring FAD, NADPH and heme prosthetic groups in addition to either calcium or a various number of cytosolic mediators for
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CircSV2b participates in oxidative stress regulation through miR-5107-5p-Foxk1-Akt1 axis in Parkinson's disease Redox Biol. (IF 10.787) Pub Date : 2022-08-12 Quancheng Cheng, Jianwei Wang, Man Li, Jinyu Fang, Huiru Ding, Jieyi Meng, Junwei Zhang, Xuan Fang, Huaicun Liu, Chao Ma, Chunhua Chen, Weiguang Zhang
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Vitamin C deficiency induces hypoglycemia and cognitive disorder through S-nitrosylation-mediated activation of glycogen synthase kinase 3β Redox Biol. (IF 10.787) Pub Date : 2022-08-08 Yingying Shu, Chaochun Zou, Yuqing Cai, Qiangqiang He, Xiaowei Wu, Haibin Zhu, Meiyu Qv, Yunqi Chao, Chengyun Xu, Lanfang Tang, Ximei Wu
Vitamin C (VC, l-ascorbic acid) is an essential nutrient that plays a key role in metabolism and functions as a potent antioxidant in regulating the S-nitrosylation and denitrosylation of target proteins. The precise function of VC deprivation in glucose homeostasis is still unknown. In the absence of L-gulono-1,4-lactone oxidoreductase, an essential enzyme for the last step of VC synthesis, VC deprivation
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Every islet matters: improving the impact of human islet research Nat. Metab. (IF 19.865) Pub Date : 2022-08-11 Anna L. Gloyn, Mark Ibberson, Piero Marchetti, Alvin C. Powers, Patrik Rorsman, Maike Sander, Michele Solimena
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Reply to: Local news in Google News Nat. Hum. Behav. (IF 24.252) Pub Date : 2022-08-11 Sean Fischer, Kokil Jaidka, Yphtach Lelkes
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Developmental and epileptic encephalopathies: from genetic heterogeneity to phenotypic continuum Physiol. Rev. (IF 46.5) Pub Date : 2022-08-11 Renzo Guerrini, Valerio Conti, Massimo Mantegazza, Simona Balestrini, Aristea S. Galanopoulou, Fabio Benfenati
Developmental and epileptic encephalopathies are a heterogeneous group of disorders characterized by early-onset, often severe epileptic seizures, EEG abnormalities, on a background of developmental impairment that tends to worsen as a consequence of epilepsy. DEEs may result from both non-genetic and genetic etiologies. Genetic DEEs have been associated with mutations in many genes involved in different
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Neutrophil extracellular traps in the pathology of cancer and other inflammatory diseases Physiol. Rev. (IF 46.5) Pub Date : 2022-08-11 Melanie Herre, Jessica Cedervall, Nigel Mackman, Anna-Karin Olsson
Neutrophil extracellular trap (NET) formation, first described in 2004 as a previously unknown strategy of neutrophils to fight microbes, has attracted an increasing interest in the research community. NETs are formed when neutrophils externalize their decondensed chromatin together with content from their azurophilic granules. In addition to their role in defense against microbes, NETs have been implicated
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The Ebb and Flow of Cardiac Lymphatics: A Tidal Wave of New Discoveries Physiol. Rev. (IF 46.5) Pub Date : 2022-08-11 Natalie R. Harris, Laszlo Balint, Danielle M. Dy, Natalie R. Nielsen, Hernán G. Méndez, Amir Aghajanian, Kathleen M. Caron
The heart is imbued with a vast lymphatic network which is responsible for fluid homeostasis and immune cell trafficking. Disturbances in the forces that regulate microvascular fluid movement can result in myocardial edema, which has pro-fibrotic and pro-inflammatory consequences and contributes to cardiovascular dysfunction. This review explores the complex relationship between cardiac lymphatics
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The physiological functions of human peroxisomes Physiol. Rev. (IF 46.5) Pub Date : 2022-08-11 Ronald J.A. Wanders, Myriam Baes, Daniela Ribeiro, Sacha Ferdinandusse, Hans R. Waterham
Peroxisomes are subcellular organelles which play a central role in human physiology by catalyzing a range of unique metabolic functions. The importance of peroxisomes for human health is exemplified by the existence of a group of usually severe diseases caused by an impairment in one or more peroxisomal functions. Among others these include the Zellweger spectrum disorders, X-linked adrenoleukodystrophy
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Rapid restructuring of the odontocete community in an ocean warming hotspot Glob. Change Biol. (IF 13.211) Pub Date : 2022-08-11 L. H. Thorne, E. I. Heywood, N. O. Hirtle
Cetaceans are important consumers in marine ecosystems, but few studies have quantified their climate responses. The rapid, directional warming occurring in the Northeast United States (NEUS) provides a unique opportunity to assess climate impacts on cetaceans. We used stranding data to examine changes to the distribution and relative abundance of odontocetes from 1996-2020 in both the NEUS and the
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Three-dimensional mapping of carbon, nitrogen, and phosphorus in soil microbial biomass and their stoichiometry at the global scale Glob. Change Biol. (IF 13.211) Pub Date : 2022-08-10 Decai Gao, Edith Bai, Siyu Wang, Shengwei Zong, Ziping Liu, Xianlei Fan, Chunhong Zhao, Frank Hagedorn
Soil microbial biomass and microbial stoichiometric ratios are important for understanding carbon and nutrient cycling in terrestrial ecosystems. Here, we compiled data from 8862 observations of soil microbial biomass from 1626 published studies to map global patterns of microbial biomass carbon (MBC), microbial biomass nitrogen (MBN), microbial biomass phosphorus (MBP), and their stoichiometry using
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Obesity impairs skeletal muscle repair through NID-1 mediated extracellular matrix remodeling by mesenchymal progenitors Matrix Biol. (IF 10.447) Pub Date : 2022-08-11 Sergio Pérez-Díaz, Zeynab Koumaiha, Matthew Jay Borok, Frederic Aurade, Maria Pini, Baptiste Periou, Christine Rouault, Yasmine Baba-Amer, Karine Clément, Genevieve Derumeaux, François Jérôme Authier, Peggy Lafuste, Frederic Relaix
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RIPK3-MLKL signaling activates mitochondrial CaMKII and drives intrarenal extracellular matrix production during CKD Matrix Biol. (IF 10.447) Pub Date : 2022-08-11 Anjali Srivastava, Bhawna Tomar, Pravesh Sharma, Sunaina Kumari, Shakti Prakash, Srikanta Kumar Rath, Onkar Prakash Kulkarni, Shashi Kumar Gupta, Shrikant R. Mulay
Intrarenal extracellular matrix production is a prevalent feature of all forms of chronic kidney disease (CKD). The transforming growth factor-beta (TGFβ) is believed to be a major driver of extracellular matrix production. Nevertheless, anti-TGFβ therapies have consistently failed to reduce extracellular matrix production in CKD patients indicating the need for novel therapeutic strategies. We have
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Functional Trade-offs Asymmetrically Promote Phenotypic Evolution Syst. Biol. (IF 9.16) Pub Date : 2022-08-12 Edward D Burress, Martha M Muñoz
Trade-offs are thought to bias evolution and are core features of many anatomical systems. Therefore, trade-offs may have far-reaching macroevolutionary consequences, including patterns of morphological, functional, and ecological diversity. Jaws, like many complex anatomical systems, are comprised of elements involved in biomechanical trade-offs. We test the impact of a core mechanical trade-off,
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FELASA2022 – Communication as a driver for better science, transparency, and animal welfare Lab Anim. (IF 9.667) Pub Date : 2022-08-10 Nuno Henrique Franco, Vootele Voikar
World-changing events took place between the 2019 and 2022 FELASA congresses. The challenges imposed by the Covid-19 pandemic highlighted the importance of animal research, and were an unavoidable issue discussed at FELASA2022. However, it was the future of laboratory animal science, medicine, and education that took central stage ─ a future that will rely on improved ‘Communication’ between all stakeholders
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Spatiotemporal influences of climate and humans on muskox range dynamics over multiple millennia Glob. Change Biol. (IF 13.211) Pub Date : 2022-08-10 Elisabetta Canteri, Stuart C. Brown, Niels Martin Schmidt, Rasmus Heller, David Nogues-Bravo, Damien A. Fordham
Processes leading to range contractions and population declines of Arctic megafauna during the late Pleistocene and early-Holocene are uncertain, with intense debate on the roles of human hunting, climatic change, and their synergy. Obstacles to a resolution, have included an over reliance on correlative rather than process-explicit approaches for inferring drivers of distributional and demographic
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The importance of considering the duration of extreme temperatures when investigating responses to climate change Glob. Change Biol. (IF 13.211) Pub Date : 2022-08-10 Teija Isotalo, Lilla Rotenbiller, Ulrika Candolin
The frequency and duration of heatwaves are increasing because of human activities. To cope with the changes, species with longer generation times may have to rely on plastic responses. The probability that their responses are adaptive is higher if the species have experienced temperature fluctuations also in their evolutionary past. However, experimental studies investigating responses to heatwaves
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Local groundwater decline exacerbates response of dryland riparian woodlands to climatic drought Glob. Change Biol. (IF 13.211) Pub Date : 2022-08-10 Jared Williams, John C. Stella, Steven L. Voelker, Adam M. Lambert, Lissa Pelletier, John E. Drake, Jonathan M. Friedman, Dar A. Roberts, Michael Bliss Singer
Dryland riparian woodlands are considered to be locally buffered from droughts by shallow and stable groundwater levels. However, climate change is causing more frequent and severe drought events, accompanied by warmer temperatures, collectively threatening the persistence of these groundwater dependent ecosystems through a combination of increasing evaporative demand and decreasing groundwater supply
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Mitochondrial and redox modifications in early stages of Huntington's disease Redox Biol. (IF 10.787) Pub Date : 2022-08-10 Carla Lopes, I. Luísa Ferreira, Carina Maranga, Margarida Beatriz, Sandra I. Mota, José Sereno, João Castelhano, Antero Abrunhosa, Francisco Oliveira, Maura De Rosa, Michael Hayden, Mário N. Laço, Cristina Januário, Miguel Castelo Branco, A. Cristina Rego
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Rapid and selective generation of H2S within mitochondria protects against cardiac ischemia-reperfusion injury Redox Biol. (IF 10.787) Pub Date : 2022-08-05 Jan Lj. Miljkovic, Nils Burger, Justyna M. Gawel, John F. Mulvey, Abigail A.I. Norman, Takanori Nishimura, Yoshiyuki Tsujihata, Angela Logan, Olga Sauchanka, Stuart T. Caldwell, Jordan L. Morris, Tracy A. Prime, Stefan Warrington, Julien Prudent, Georgina R. Bates, Dunja Aksentijević, Hiran A. Prag, Andrew M. James, Michael P. Murphy
Mitochondria-targeted H2S donors are thought to protect against acute ischemia-reperfusion (IR) injury by releasing H2S that decreases oxidative damage. However, the rate of H2S release by current donors is too slow to be effective upon administration following reperfusion. To overcome this limitation here we develop a mitochondria-targeted agent, MitoPerSulf that very rapidly releases H2S within mitochondria
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Response to Open Peer Commentaries on Toward a Framework for Assessing Privacy Risks in Multi-Omic Research and Databases Am. J. Bioethics (IF 14.676) Pub Date : 2022-08-09 Charles Dupras, Eline M. Bunnik
Published in The American Journal of Bioethics (Ahead of Print, 2022)
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Vesicle choreographies keep up cell-to-extracellular matrix adhesion dynamics in polarized epithelial and endothelial cells Matrix Biol. (IF 10.447) Pub Date : 2022-08-09 Giulia Villari, Noemi Gioelli, Donatella Valdembri, Guido Serini
In metazoans, cell adhesion to the extracellular matrix (ECM) drives the development, functioning, and repair of different tissues, organs, and systems. Disruption or dysregulation of cell-to-ECM adhesion promote the initiation and progression of several diseases, such as bleeding, immune disorders and cancer. Integrins are major ECM transmembrane receptors, whose function depends on both allosteric
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Collagen VI ablation in zebrafish causes neuromuscular defects during developmental and adult stages Matrix Biol. (IF 10.447) Pub Date : 2022-08-09 Valentina Tonelotto, Chiara Consorti, Nicola Facchinello, Valeria Trapani, Patrizia Sabatelli, Chiara Giraudo, Marianna Spizzotin, Matilde Cescon, Cristiano Bertolucci, Paolo Bonaldo
Collagen VI (COL6) is an extracellular matrix protein exerting multiple functions in different tissues. In humans, mutations of COL6 genes cause rare inherited congenital disorders, primarily affecting skeletal muscles and collectively known as COL6-related myopathies, for which no cure is available yet. In order to get insights into the pathogenic mechanisms underlying COL6-related diseases, diverse
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Shining a light on SSP4: A comprehensive analysis and biological applications for the detection of sulfane sulfurs Redox Biol. (IF 10.787) Pub Date : 2022-08-09 Meg Shieh, Xiang Ni, Shi Xu, Stephen P. Lindahl, Moua Yang, Tetsuro Matsunaga, Robert C. Flaumenhaft, Takaaki Akaike, Ming Xian
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Deep blue autofluorescence reflects the oxidation state of human transthyretin Redox Biol. (IF 10.787) Pub Date : 2022-08-09 Elżbieta Wieczorek, Zofia Wygralak, Sylwia Kędracka-Krok, Patrycja Bezara, Dominika Bystranowska, Piotr Dobryszycki, Andrzej Ożyhar
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Resilient government requires data science reform Nat. Hum. Behav. (IF 24.252) Pub Date : 2022-08-08 Ben D. MacArthur, Cosmina L. Dorobantu, Helen Z. Margetts
Data has tremendous potential to build resilience in government. To realize this potential, we need a new, human-centred, distinctly public sector approach to data science and AI, in which these technologies do not just automate or turbocharge what humans can already do well, but rather do things that people cannot.
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Hate crime towards minoritized groups increases as they increase in sized-based rank Nat. Hum. Behav. (IF 24.252) Pub Date : 2022-08-08 Mina Cikara, Vasiliki Fouka, Marco Tabellini
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Nav1.8 in keratinocytes contributes to ROS-mediated inflammation in inflammatory skin diseases Redox Biol. (IF 10.787) Pub Date : 2022-08-05 Yiya Zhang, Yangfan Li, Lei Zhou, Xin Yuan, Yaling Wang, Qing Deng, Zhili Deng, San Xu, Qian Wang, Hongfu Xie, Ji Li
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Introducing the Lipidomics Minimal Reporting Checklist Nat. Metab. (IF 19.865) Pub Date : 2022-08-08 Jeffrey G. McDonald, Christer S. Ejsing, Dominik Kopczynski, Michal Holčapek, Junken Aoki, Makoto Arita, Masanori Arita, Erin S. Baker, Justine Bertrand-Michel, John A. Bowden, Britta Brügger, Shane R. Ellis, Maria Fedorova, William J. Griffiths, Xianlin Han, Jürgen Hartler, Nils Hoffmann, Jeremy P. Koelmel, Harald C. Köfeler, Todd W. Mitchell, Valerie B. O’Donnell, Daisuke Saigusa, Dominik Schwudke
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Visualization and quantification of carbon “rusty sink” by rice root iron plaque: mechanisms, functions, and global implications Glob. Change Biol. (IF 13.211) Pub Date : 2022-08-05 Liang Wei, Zhenke Zhu, Bahar S. Razavi, Mouliang Xiao, Maxim Dorodnikov, Lichao Fan, Hongzhao Yuan, Andrey Yurtaev, Yu Luo, Weiguo Cheng, Yakov Kuzyakov, Jinshui Wu, Tida Ge
Paddies contain 78% higher organic carbon (C) stocks than adjacent upland soils, and iron (Fe) plaque formation on rice roots is one of the mechanisms that traps C. The process sequence, extent and global relevance of this C stabilization mechanism under oxic/anoxic conditions remains unclear. We quantified and localized the contribution of Fe plaque to organic matter stabilization in a microoxic area
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Recommendations for quantifying and reducing uncertainty in climate projections of species distributions Glob. Change Biol. (IF 13.211) Pub Date : 2022-08-05 Stephanie Brodie, James A. Smith, Barbara A. Muhling, Lewis A. K. Barnett, Gemma Carroll, Paul Fiedler, Steven J. Bograd, Elliott L. Hazen, Michael G. Jacox, Kelly S. Andrews, Cheryl L. Barnes, Lisa G. Crozier, Jerome Fiechter, Alexa Fredston, Melissa A. Haltuch, Chris J. Harvey, Elizabeth Holmes, Melissa A. Karp, Owen R. Liu, Michael J. Malick, Mercedes Pozo Buil, Kate Richerson, Christopher N. Rooper
Projecting the future distributions of commercially and ecologically important species has become a critical approach for ecosystem managers to strategically anticipate change, but large uncertainties in projections limit climate adaptation planning. Although distribution projections are primarily used to understand the scope of potential change - rather than accurately predict specific outcomes -
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Responses of soil greenhouse gas emissions to land use conversion and reversion — A global meta-analysis Glob. Change Biol. (IF 13.211) Pub Date : 2022-08-05 Zhaohui Feng, Lingqing Wang, Xiaoming Wan, Jun Yang, Qin Peng, Tao Liang, Yazhu Wang, Buqing Zhong, Jörg Rinklebe
Exploring the responses of greenhouse gases (GHGs) emissions to land use conversion or reversion is significant for taking effective land use measures to alleviate global warming. A global meta-analysis was conducted to analyze the responses of carbon dioxide (CO2), methane (CH4) and nitrous oxide (N2O) emissions to land use conversion or reversion, and determine their temporal evolution, driving factors
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Sympatric soil biota mitigate a warmer-drier climate for Bouteloua gracilis Glob. Change Biol. (IF 13.211) Pub Date : 2022-08-04 Michael J. Remke, Nancy C. Johnson, Matthew A. Bowker
Abstract
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Urbanization causes biotic homogenization of woodland bird communities at multiple spatial scales Glob. Change Biol. (IF 13.211) Pub Date : 2022-08-03 William Sidemo-Holm, Johan Ekroos, Santiago Reina García, Bo Söderström, Marcus Hedblom
Urbanization is a major contributor to biodiversity declines. However, studies assessing effects of urban landscapes per se (i.e., disentangled from focal habitat effects) on biodiversity across spatial scales are lacking. Understanding such scale-dependent effects is fundamental to preserve habitats along an urbanization gradient in a way that maximizes overall biodiversity. We investigated the impact
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Toward a decade of ocean science for sustainable development through acoustic animal tracking Glob. Change Biol. (IF 13.211) Pub Date : 2022-08-05 Josep Alós, Kim Aarestrup, David Abecasis, Pedro Afonso, Alexandre Alonso-Fernandez, Eneko Aspillaga, Margarida Barcelo-Serra, Jonathan Bolland, Miguel Cabanellas-Reboredo, Robert Lennox, Ross McGill, Aytaç Özgül, Jan Reubens, David Villegas-Ríos
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Live-fast-die-young: Carryover effects of heatwave-exposed adult urchins on the development of the next generation Glob. Change Biol. (IF 13.211) Pub Date : 2022-08-03 Jay J. Minuti, Maria Byrne, Hamish Campbell, Deevesh A. Hemraj, Bayden D. Russell
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Career pathways, part 9 Nat. Metab. (IF 19.865) Pub Date : 2022-08-05 Evanna L. Mills, Edward T. Chouchani
Evanna Mills and Edward Chouchani share the experience of their successful mentor–mentee relationship and talk about the challenges of starting a new lab — both from a recent perspective and five years on.
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Chemotherapy treatment induces pro-invasive changes in liver ECM composition Matrix Biol. (IF 10.447) Pub Date : 2022-08-05 Justinne R. Guarin, Jackson P. Fatherree, Madeleine J. Oudin
Metastasis accounts for 90% of cancer-related deaths, yet the mechanisms by which cancer cells colonize secondary organs remain poorly understood. For breast cancer patients, metastasis to the liver is associated with poor prognosis and a median survival of 6 months. Standard of care is chemotherapy, but recurrence occurs in 30% of patients. Systemic chemotherapy has been shown to induce hepatotoxicity
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Latent Transforming Growth Factor β Binding Protein 3 Controls Adipogenesis Matrix Biol. (IF 10.447) Pub Date : 2022-08-04 Karan Singh, Nalani Sachan, Taylor Ene, Branka Dabovic, Daniel Rifkin
Transforming growth factor-beta (TGFβ) is released from cells as part of a trimeric latent complex consisting of TGFβ, the TGFβ propeptides, and either a latent TGFβ binding protein (LTBP) or glycoprotein-A repetitions predominant (GARP) protein. LTBP1 and 3 modulate latent TGFβ function with respect to secretion, matrix localization, and activation and, therefore, are vital for the proper function
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Rare genetic variants explain missing heritability in smoking Nat. Hum. Behav. (IF 24.252) Pub Date : 2022-08-04 Seon-Kyeong Jang, Luke Evans, Allison Fialkowski, Donna K. Arnett, Allison E. Ashley-Koch, Kathleen C. Barnes, Diane M. Becker, Joshua C. Bis, John Blangero, Eugene R. Bleecker, Meher Preethi Boorgula, Donald W. Bowden, Jennifer A. Brody, Brian E. Cade, Brenda W. Campbell Jenkins, April P. Carson, Sameer Chavan, L. Adrienne Cupples, Brian Custer, Scott M. Damrauer, Sean P. David, Mariza de Andrade
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Phospholipid peroxidation inhibits autophagy via stimulating the delipidation of oxidized LC3-PE Redox Biol. (IF 10.787) Pub Date : 2022-08-05 Wen Li, Lian-Xiang Luo, Qing-Qing Zhou, Hai-Biao Gong, Yuan-Yuan Fu, Chang-Yu Yan, E. Li, Jie Sun, Zhuo Luo, Zhao-Jun Ding, Qiong-Yi Zhang, Han-Lu Mu, Yun-Feng Cao, Shu-Hua Ouyang, Hiroshi Kurihara, Yi-Fang Li, Wan-Yang Sun, Min Li, Rong-Rong He
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The loss of pancreatic islet NADPH oxidase (NOX)2 improves islet transplantation Redox Biol. (IF 10.787) Pub Date : 2022-07-31 Selina Wrublewsky, Julia Glas, Christopher Carlein, Lisa Nalbach, Markus Daniel Alexander Hoffmann, Mandy Pack, Eloisa Aparecida Vilas-Boas, Nathan Ribot, Reinhard Kappl, Michael D. Menger, Matthias W. Laschke, Emmanuel Ampofo, Leticia Prates Roma
Islet transplantation is a promising treatment strategy for type 1 diabetes mellitus (T1DM) patients. However, oxidative stress-induced graft failure due to an insufficient revascularization is a major problem of this therapeutic approach. NADPH oxidase (NOX)2 is an important producer of reactive oxygen species (ROS) and several studies have already reported that this enzyme plays a crucial role in
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Aspirin promotes RSL3-induced ferroptosis by suppressing mTOR/SREBP-1/SCD1-mediated lipogenesis in PIK3CA-mutatnt colorectal cancer Redox Biol. (IF 10.787) Pub Date : 2022-08-04 Hao Chen, Qinqin Qi, Nan Wu, Ying Wang, Qian Feng, Rong Jin, Lei Jiang
Ferroptosis, a new form of regulated cell death triggered by the iron-dependent peroxidation of phospholipids, is associated with cellular metabolism, redox homeostasis, and various signaling pathways related to cancer. Aspirin is a widely used non-steroidal anti-inflammatory drug (NSAID) and has been reported to show therapeutic benefit in cancers harboring oncogenic PIK3CA, which encodes the catalytic
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NCOA4-mediated ferritinophagy is involved in ionizing radiation-induced ferroptosis of intestinal epithelial cells Redox Biol. (IF 10.787) Pub Date : 2022-07-30 Hao Zhou, Ya-Li Zhou, Jiu-Ang Mao, Lin-Feng Tang, Jie Xu, Zhen-Xin Wang, Yang He, Ming Li
Ferroptosis is a newly recognized form of regulated cell death that is characterized by severe lipid peroxidation initiated by iron overload and the generation of reactive oxygen species (ROS). However, the role of iron in ionizing radiation (IR)-induced intestinal injury has not been fully illustrated yet. In this study, we found that IR induced ferroptosis in intestinal epithelial cells, as indicated
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Why I’m Not Backing down from Fighting for Our Right to Abortion Am. J. Bioethics (IF 14.676) Pub Date : 2022-08-02 Judy Chu
Published in The American Journal of Bioethics (Vol. 22, No. 8, 2022)
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Ending the Debate Whether State-Mandated Pregnancies are Matters of Bioethics Concern Am. J. Bioethics (IF 14.676) Pub Date : 2022-08-02 Michele Goodwin
Published in The American Journal of Bioethics (Vol. 22, No. 8, 2022)
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Yes, All Bioethicists Should Engage Abortion Ethics, but Who Would Be Interested in What They Have to Say? Am. J. Bioethics (IF 14.676) Pub Date : 2022-08-02 Nathan Nobis
Published in The American Journal of Bioethics (Vol. 22, No. 8, 2022)
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Executive, Legislative, Judiciary, & Clinic: How the Fall of Roe Will Entrench Clinicians as Agents of the State and Create Ethical Conflicts throughout Medical Practice Am. J. Bioethics (IF 14.676) Pub Date : 2022-08-02 Erica Andrist
Published in The American Journal of Bioethics (Vol. 22, No. 8, 2022)
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Roe v. Wade Was a Profound Disservice to the Country Am. J. Bioethics (IF 14.676) Pub Date : 2022-08-02 Wesley J. Smith
Published in The American Journal of Bioethics (Vol. 22, No. 8, 2022)
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Travel to Other States for Abortion after Dobbs Am. J. Bioethics (IF 14.676) Pub Date : 2022-08-02 I. Glenn Cohen
Published in The American Journal of Bioethics (Vol. 22, No. 8, 2022)
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Trauma Upon Trauma Am. J. Bioethics (IF 14.676) Pub Date : 2022-08-02 Megan Antonetti
Published in The American Journal of Bioethics (Vol. 22, No. 8, 2022)
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Private Conversations, Public Debate Am. J. Bioethics (IF 14.676) Pub Date : 2022-08-02 Siripanth Nippita, Christina Jung, Johana D. Oviedo, Gwendolyn P. Quinn
Published in The American Journal of Bioethics (Vol. 22, No. 8, 2022)