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River Drying Causes Local Losses and Regional Gains in Aquatic Invertebrate Metacommunity Diversity: A Cross-Continental Comparison Glob. Change Biol. (IF 10.8) Pub Date : 2025-02-14 Daniel Escobar-Camacho, Julie Crabot, Rachel Stubbington, Judy England, Romain Sarremejane, Núria Bonada, José María Fernández-Calero, Miguel Cañedo-Argüelles, Carla Ferreira Rezende, Pierre Chanut, Zoltán Csabai, Andrea C. Encalada, Alex Laini, Heikki Mykrä, Nabor Moya, Petr Pařil, Daniela Rosero-López, Thibault Datry
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Greenhouse Gas Emissions and Lateral Carbon Dynamics at an Eroding Yedoma Permafrost Site in Siberia (Duvanny Yar) Glob. Change Biol. (IF 10.8) Pub Date : 2025-02-14 Kirsi H. Keskitalo, Lisa Bröder, Dirk J. Jong, Paul J. Mann, Tommaso Tesi, Anna Davydova, Nikita Zimov, Negar Haghipour, Timothy I. Eglinton, Jorien E. Vonk
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Vulnerability of Labile Organic Matter to Eutrophication and Warming in Temperate Mangrove Ecosystems Glob. Change Biol. (IF 10.8) Pub Date : 2025-02-14 Timothy Thomson, Conrad A. Pilditch, Marco Fusi, Natalie Prinz, Carolyn J. Lundquist, Joanne I. Ellis
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Bearing the Humans Glob. Change Biol. (IF 10.8) Pub Date : 2025-02-14 Andrea Corradini, Steffen Mumme, Francesca Cagnacci
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Stronger Response of Plant N:P to Nitrogen Enrichment When Considering Roots Glob. Change Biol. (IF 10.8) Pub Date : 2025-02-14 Yu Ning, Feike A. Dijkstra, Xiao-Sa Liang, Xiao-Jing Zhang, Guo-Jiao Yang, Liang-Chao Jiang, Xing-Guo Han, Xiao-Tao Lü
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Physiologic mechanisms underlying polycystic kidney disease Physiol. Rev. (IF 29.9) Pub Date : 2025-02-13 Alessandra Boletta, Michael J. Caplan
Physiological Reviews, Ahead of Print.
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Timing Matters: Viticultural Land Use Determines Responses in Structure and Function of Fungal Stream Communities Across One Growing Season Glob. Change Biol. (IF 10.8) Pub Date : 2025-02-13 Verena C. Schreiner, Moritz Link, Gesa Amelung, Katharina Ohler, Romana Salis, Florian Leese, Ralf B. Schäfer
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Late Holocene “Turn‐Off” of Coral Reef Growth in the Northern Red Sea and Implications for a Sea‐Level Fall Glob. Change Biol. (IF 10.8) Pub Date : 2025-02-12 B. Feldman, A. Torfstein, M. O'Leary, N. Simon Blecher, R. Yam, Y. Shaked, A. Shemesh, D. Huang, O. Levy
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Drought Impacts on Plant–Soil Carbon Allocation—Integrating Future Mean Climatic Conditions Glob. Change Biol. (IF 10.8) Pub Date : 2025-02-12 Vinzent Leyrer, Juliette Blum, Sven Marhan, Ellen Kandeler, Telse Zimmermann, Bernd J. Berauer, Andreas H. Schweiger, Alberto Canarini, Andreas Richter, Christian Poll
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Author Correction: A feeding-induced myokine modulates glucose homeostasis. Nat. Metab. (IF 18.9) Pub Date : 2025-02-11 Xiaoliu Shi,Xiao Hu,Xinlei Fang,Liangjie Jia,Fangchao Wei,Ying Peng,Menghao Liu,Aibo Gao,Ke Zhao,Fengyi Chen,Xiaoli Hu,Jie Hong,Guang Ning,Yongfeng Song,Jiqiu Wang,Yiguo Wang
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Twenty‐First‐Century Environmental Change Decreases Habitat Overlap of Antarctic Toothfish (Dissostichus mawsoni) and Its Prey Glob. Change Biol. (IF 10.8) Pub Date : 2025-02-11 Cara Nissen, Jilda Alicia Caccavo, Anne L. Morée
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Navigating Climate Change: Exploring the Dynamics Between Plant–Soil Microbiomes and Their Impact on Plant Growth and Productivity Glob. Change Biol. (IF 10.8) Pub Date : 2025-02-11 Murad Muhammad, Abdul Wahab, Abdul Waheed, Khalid Rehman Hakeem, Heba Ibrahim Mohamed, Abdul Basit, Muhammad Danish Toor, Yong‐Hong Liu, Li Li, Wen‐Jun Li
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Leaf Temperatures in an Indian Tropical Forest Exceed Physiological Limits but Durations of Exposures Are Currently Not Sufficient to Cause Lasting Damage Glob. Change Biol. (IF 10.8) Pub Date : 2025-02-11 Akhil Javad, Vikhyath Premugh, Rakesh Tiwari, Peddiraju Bandaru, Ron Sunny, Balachandra Hegde, Santiago Clerici, David Galbraith, Manuel Gloor, Deepak Barua
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Molecular Dissection of the Role of ACE2 in Glucose Homeostasis Physiol. Rev. (IF 29.9) Pub Date : 2025-02-07 Kavaljit H. Chhabra, Robin Shoemaker, Chandana B. Herath, Merlin C. Thomas, Catalin M. Filipeanu, Eric Lazartigues
Physiological Reviews, Ahead of Print.
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Metabolic Messengers: small extracellular vesicles Nat. Metab. (IF 18.9) Pub Date : 2025-02-07 Theresa V. Rohm, Karina Cunha e Rocha, Jerrold M. Olefsky
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Turning Up the Heat: More Persistent Precipitation Regimes Weaken the Micro‐Climate Buffering Capacity of Forage Grasses During a Hot Summer Glob. Change Biol. (IF 10.8) Pub Date : 2025-02-07 Simon Reynaert, Ivan Nijs, Tommy D'Hose, Erik Verbruggen, Jutte Callaerts, Hans J. De Boeck
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Increasing Hydroclimatic Whiplash Can Amplify Wildfire Risk in a Warming Climate Glob. Change Biol. (IF 10.8) Pub Date : 2025-02-07 Daniel L. Swain, John T. Abatzoglou, Christine M. Albano, Manuela I. Brunner, Noah S. Diffenbaugh, Crystal Kolden, Andreas F. Prein, Deepti Singh, Christopher B. Skinner, Thomas W. Swetnam, Danielle Touma
On January 7 and 8, 2025, a series of wind-driven wildfires occurred in Los Angeles County in Southern California. Two of these fires ignited in dense woody chaparral shrubland and immediately burned into adjacent populated areas–the Palisades Fire on the coastal slopes of the Santa Monica Mountains and the Eaton fire in the foothills of the San Gabriel Mountains. Both fires ultimately eclipsed the
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Interactions Between Climate Mean and Variability Drive Future Agroecosystem Vulnerability Glob. Change Biol. (IF 10.8) Pub Date : 2025-02-07 Eva Sinha, Donghui Xu, Kendalynn A. Morris, Beth A. Drewniak, Ben Bond‐Lamberty
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Translocation renal cell carcinoma says no to the Warburg effect Nat. Metab. (IF 18.9) Pub Date : 2025-02-06 Xingxiu Pan, Valentin Cracan
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Oncogenic TFE3 fusions drive OXPHOS and confer metabolic vulnerabilities in translocation renal cell carcinoma Nat. Metab. (IF 18.9) Pub Date : 2025-02-06 Jiao Li, Kaimeng Huang, Meha Thakur, Fiona McBride, Ananthan Sadagopan, Daniel S. Gallant, Prateek Khanna, Yasmin Nabil Laimon, Bingchen Li, Razan Mohanna, Maolin Ge, Cary N. Weiss, Mingkee Achom, Qingru Xu, Sayed Matar, Gwo-Shu Mary Lee, Kun Huang, Miao Gui, Chin-Lee Wu, Kristine M. Cornejo, Toni K. Choueiri, Birgitta A. Ryback, Sabina Signoretti, Liron Bar-Peled, Srinivas R. Viswanathan
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Beyond Doomsday Fears: Why We Need to Consider the Potential Harms of AI Psychotherapy. Am. J. Bioethics (IF 17.0) Pub Date : 2025-02-06 Şerife Tekin,Megan Delehanty
There is increased enthusiasm about the use of Artificial Intelligence (AI) technologies in psychotherapy. Notably, AI psychotherapy chatbots are increasing in popularity, especially since the US Food and Drug Administration (FDA) gave one of these apps breakthrough device designation. This article raises concerns about the lack of consideration of potential harms of this technology for clinical trial
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Dystrophic epidermolysis bullosa - From biochemistry to interventions Matrix Biol. (IF 4.5) Pub Date : 2025-02-06 Alexander Nyström
The skin, as a barrier organ meeting constant mechanical challenges, is equipped with multiple adhesive structures that collectively support resilient, yet flexible attachment of its epithelium –the epidermis to its mesenchyme – the dermis. One such structure is the collagen VII-composed anchoring fibril, which provides firm anchorage of the epidermal basement membrane to the underlying interstitial
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A future without needles: non-invasive glucose measurements in patients with diabetes Nat. Metab. (IF 18.9) Pub Date : 2025-02-05 Andreas L. Birkenfeld, Vasilis Ntziachristos
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Subcutaneous depth-selective spectral imaging with mμSORS enables noninvasive glucose monitoring Nat. Metab. (IF 18.9) Pub Date : 2025-02-05 Yifei Zhang, Lili Zhang, Long Wang, Shuai Shao, Bei Tao, Chunrui Hu, Yufei Chen, Yue Shen, Xianbiao Zhang, Shijia Pan, Hua Cao, Ming Sun, Jia Shi, Chunhong Jiang, Minghui Chen, Lin Zhou, Guang Ning, Chang Chen, Weiqing Wang
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Zoonotic Host Richness in the Global Wildland–Urban Interface Glob. Change Biol. (IF 10.8) Pub Date : 2025-02-05 Rohan D. Simkin, Barbara A. Han, Volker C. Radeloff, Shannon LaDeau, Franz Schug, Karen C. Seto
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Broad‐Scale Meta‐Analysis of Drivers Mediating Adverse Impacts of Flow Regulation on Riparian Vegetation Glob. Change Biol. (IF 10.8) Pub Date : 2025-02-05 Xiaolei Su, María Dolores Bejarano, Roland Jansson, Francesca Pilotto, Judith M. Sarneel, Feng Lin, Yi Wang, Fu Cai, Shan Wu, Bo Zeng
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Local‐ and Regional‐Scale Climate Variability Drives Complex Patterns of Growth Synchrony and Asynchrony in Deep‐Sea Snappers Across the Indo‐Pacific Glob. Change Biol. (IF 10.8) Pub Date : 2025-02-05 Joseph B. Widdrington, Patrick Reis‐Santos, Jed I. Macdonald, Bradley R. Moore, Simon J. Nicol, John R. Morrongiello, Bronwyn M. Gillanders
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Reducing Fire Severity and Extent Bolsters Subalpine Forest Resilience to Global Change Through Key Demographic Pathways Glob. Change Biol. (IF 10.8) Pub Date : 2025-02-05 Daniel L. Perret, David M. Bell, Harold S. J. Zald
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Soil Moisture Threshold of Methane Uptake in Alpine Grassland Ecosystems Glob. Change Biol. (IF 10.8) Pub Date : 2025-02-05 Peiyan Wang, Jinsong Wang, Song Wang, Ludovica D'Imperio, Bo Elberling, Per Ambus, Zhen Zhang, Akihiko Ito, Yang Li, Junxiao Pan, Lei Song, Ning Liu, Ruiyang Zhang, Weinan Chen, Shuli Niu
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Inhibition of S100A8/A9 ameliorates neuroinflammation by blocking NET formation following traumatic brain injury Redox Biol. (IF 10.7) Pub Date : 2025-02-05 Guihong Shi, Yiyao Cao, Jianye Xu, Bo Chen, Xu Zhang, Yanlin Zhu, Liang Liu, Xilei Liu, Luyuan Zhang, Yuan Zhou, Shenghui Li, Guili Yang, Xiao Liu, Fanglian Chen, Xin Chen, Jianning Zhang, Shu Zhang
Traumatic brain injury (TBI) triggers a robust inflammatory response that is closely linked to worsened clinical outcomes. S100A8/A9, also known as calprotectin or myeloid-related protein-8/14 (MRP8/14), is an alarmin primarily secreted by activated neutrophils with potent pro-inflammatory property. In this study, we explored the roles of S100A8/A9 in modulating neuroinflammation and influencing TBI
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The nonlinear cysteine redox dynamics in the i-space: A proteoform-centric theory of redox regulation Redox Biol. (IF 10.7) Pub Date : 2025-02-05 James N. Cobley, Panagiotis N. Chatzinikolaou, Cameron A. Schmidt
The post-translational redox regulation of protein function by cysteine oxidation controls diverse biological processes, from cell division to death. However, most current site-centric paradigms fail to capture the nonlinear and emergent nature of redox regulation in proteins with multiple cysteines. Here, we present a proteoform-centric theory of redox regulation grounded in the i-space. The i-space
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Lipid dysregulation in triple negative breast cancer: Insights from mass spectrometry-based approaches Prog. Lipid. Res. (IF 14.0) Pub Date : 2025-02-04 Xiaoyue Huang, Ahmed Ali, Dounia E.I. Yachioui, Sylvia E. Le Dévédec, Thomas Hankemeier
Triple negative breast cancer (TNBC) has the worst prognosis among breast cancers due to its aggressive nature and the absence of targeted treatments. Development of novel anti-cancer drugs for TNBC faces challenges stemming from its heterogeneity and high potential for metastasis. Metabolomics can be a useful technology in finding novel therapeutic targets and probing the heterogeneity of TNBC. Metabolomics
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Planted Forests in China Have Higher Drought Risk Than Natural Forests Glob. Change Biol. (IF 10.8) Pub Date : 2025-02-04 Longlong Ma, Jun Ma, Pu Yan, Feng Tian, Josep Peñuelas, Mukund Palat Rao, Yongshuo Fu, Zhenhong Hu
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Genetic interaction between oxidative stress and body mass index in a Spanish population Redox Biol. (IF 10.7) Pub Date : 2025-02-04 Francisco Lara-Hernández, Rebeca Melero, María Elena Quiroz-Rodríguez, Celeste Moya-Valera, Mariana de Jesús Gallardo-Espinoza, Luis Álvarez, Ingrid Lizeth Valarezo-Torres, Laisa Briongos-Figuero, Jessica Abadía-Otero, Francisco Javier Mena-Martin, Guillermo Saez, Josep Redon, Juan-Carlos Martín-Escudero, Ana-Bárbara García-García, Guillermo Ayala, Felipe Javier Chaves
Oxidative stress may act as a contributing factor in the development of an elevated body mass index (BMI). Oxidative stress has the potential to modulate genetic activity at various levels, including gene transcription and protein function regulation. Nevertheless, the interplay between genetic variants and oxidative stress in relation to BMI remains to be elucidated. Based on this premise, we studied
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FNDC5/irisin mitigates the cardiotoxic impacts of cancer chemotherapeutics by modulating ROS-dependent and -independent mechanisms Redox Biol. (IF 10.7) Pub Date : 2025-02-04 Manish Kumar, Abhishek Singh Sengar, Anushree Lye, Pranesh Kumar, Sukhes Mukherjee, Dinesh Kumar, Priyadip Das, Suvro Chatterjee, Adele Stewart, Biswanath Maity
Cardiotoxicity remains a major limiting factor in the clinical implementation of anthracycline chemotherapy. Though the etiology of doxorubicin-dependent heart damage has yet to be fully elucidated, the ability of doxorubicin to damage DNA and trigger oxidative stress have been heavily implicated in the pathogenesis of chemotherapy-associated cardiomyopathy. Here, we demonstrate that fibronectin type
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Five ways to bridge the ‘know–do’ continuum in global health Nat. Hum. Behav. (IF 21.4) Pub Date : 2025-02-03 Malabika Sarker, Shalini Ahuja, Olakunle Alonge, Vilma Irazola, Yodi Mahendradhata, Dominic Montagu
The ‘know–do’ gap is the failure to act on evidence and knowledge from research to improve health outcomes. Considering the know–do gap as a simple linear dichotomous concept is a fallacy, because it instead represents a continuum. Five recommendations focused on this continuum can address global health challenges.
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Cultivating allyship for a diverse, equitable and inclusive academia Nat. Hum. Behav. (IF 21.4) Pub Date : 2025-02-03 Hsuan-Che ‘Brad’ Huang, Lucy De Souza, Toni Schmader
We propose six actionable steps of allyship that researchers, faculty members and educators can engage in to foster a diverse, equitable and inclusive academia: listening to marginalized voices, challenging one’s own biases, speaking up to include disadvantaged groups, speaking out to confront bias, advocating for inclusive policies and dismantling institutional biases.
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A call for precision in the study of behaviour and decision Nat. Hum. Behav. (IF 21.4) Pub Date : 2025-02-03 Dario Krpan, Barbara Fasolo, Luc Schneider
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Estrogen linked to binge drinking Lab Anim. (IF 5.9) Pub Date : 2025-02-03 Alexandra Le Bras
Although increasing evidence suggests that the sex hormone estrogen (E2) is associated with alcohol consumption in humans, the underlying mechanisms have not been fully characterized. A study in mice provides new insights into these mechanisms by showing that E2 exerts its pro-drinking effects by activating neurons in the bed nucleus of the stria terminalis (BNST). The investigators exposed male and
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Olfaction controls oogenesis in flies Lab Anim. (IF 5.9) Pub Date : 2025-02-03 Jorge Ferreira
Olfaction is one of the major senses and one of the first to develop along the evolutionary line. This sense has a major role in survival needs, like finding food or a suitable mate. With olfaction having a critical role in the assessment of external inputs, a new study in the Journal of Experimental Biology enquired whether it also has a role in regulating internal processes in Drosophila melanogaster
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Oxidation effect in sperm fertility Lab Anim. (IF 5.9) Pub Date : 2025-02-03 Jorge Ferreira
In vitro fertilization (IVF) is a reproductive method that assists in overcoming infertility. Besides the clinical setting, IVF is also used to support the production of laboratory animals for life science research. However, it is necessary to further improve the fertility rates and the success of the technique. A study in Biology of Reproduction analyzes the effect of the redox state of thiol groups
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Role of cumulus–oocyte interactions in fertility Lab Anim. (IF 5.9) Pub Date : 2025-02-03 Alexandra Le Bras
Reproductive aging in biological women is characterized by a progressive decline of ovarian function that culminates in menopause. Fertility usually decreases after age 35 with more limited pregnancies after age 40, indicating that changes in the premenopausal female reproductive tract are already occurring that negatively impact reproductive success. A study in Communications Biology shows that structural
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Pectin helps with peach allergies Lab Anim. (IF 5.9) Pub Date : 2025-02-03 Jorge Ferreira
Food allergies are a common immune reaction where symptoms can range from a slight discomfort to life-threatening situations. Peach allergy is a common food allergy in both Japan and the Mediterranean area, and this allergy still does not have an available immunotherapy. A study in Scientific Reports studied the effects of supplementing the diet of CBA/J mice that were sensitized to peach peel extract
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Tracking tumor-associated macrophages Lab Anim. (IF 5.9) Pub Date : 2025-02-03 Alexandra Le Bras
Tumor-associated macrophages (TAMs) are an essential component of the tumor microenvironment and are predominantly thought to have pro-tumor effects. Therefore, the development of imaging tracers targeting TAMs is important for tumor monitoring and therapeutic efficacy evaluation. A new study in PNAS reports the development of a nanobody-based immunotracer targeting CD163—a receptor predominantly expressed
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A new target to treat atopic dermatitis Lab Anim. (IF 5.9) Pub Date : 2025-02-03 Jorge Ferreira
Atopic dermatitis (AD) is a chronic inflammatory skin disease with known immunological alterations. Human patients with AD show a reduction of the activity of the transcription factor nuclear factor erythroid 2–related factor 2 (Nrf2) in their epidermis. However, the functional relevance of this change is still unknown. A study in Disease Models & Mechanisms used mice lacking fibroblast growth factor
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Transmission of maternal stress Lab Anim. (IF 5.9) Pub Date : 2025-02-03 Alexandra Le Bras
Prenatal maternal stress (PNMS) is associated with adverse pregnancy outcomes and predicts poorer developmental and health outcomes in the offspring. Previous studies have shown that exposure to PNMS can affect the F1 generation by inducing epigenetic modifications such as DNA methylation (DNAm) and expression of short noncoding RNAs, such as microRNAs (miRNAs). If PNMS occurs during primordial germ
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Improving Carbon Budgets by Accounting for Inorganic Carbon in Seagrass Ecosystems Glob. Change Biol. (IF 10.8) Pub Date : 2025-02-03 Yuzheng Ren, Songlin Liu, Jiening Liang, Anirban Akhand, Hongxue Luo, Zhijian Jiang, Yunchao Wu, Xiaoping Huang, Peter I. Macreadie
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Global Projection of Terrestrial Vertebrate Food Webs Under Future Climate and Land‐Use Changes Glob. Change Biol. (IF 10.8) Pub Date : 2025-02-03 Xiyang Hao, Marcel Holyoak, Zhicheng Zhang, Chuan Yan
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Coastal Marsh Vulnerability to Sea‐Level Rise Is Exacerbated by Plant Species Invasion Glob. Change Biol. (IF 10.8) Pub Date : 2025-02-03 Dawei Wang, Chuanhui Gu, Stijn Temmerman, Jean‐Philippe Belliard, Olivier Gourgue, Liming Xue, Junhong Bai
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Satellite Observations Reveal a Positive Relationship Between Trait‐Based Diversity and Drought Response in Temperate Forests Glob. Change Biol. (IF 10.8) Pub Date : 2025-02-03 Isabelle S. Helfenstein, Joan T. Sturm, Bernhard Schmid, Alexander Damm, Meredith C. Schuman, Felix Morsdorf
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Niraparib restricts intraperitoneal metastases of ovarian cancer by eliciting CD36-dependent ferroptosis Redox Biol. (IF 10.7) Pub Date : 2025-02-03 Ning Jin, Yi-yu Qian, Xiao-fei Jiao, Zhen Wang, Xin Li, Wen Pan, Jin-kai Jiang, Pu Huang, Si-yuan Wang, Ping Jin, Qing-lei Gao, Dan Liu, Yu Xia
Ovarian cancer (OC) is prone to peritoneum or omentum dissemination, thus giving rise to the formidable challenge of unresectable surgery and a dismal survival rate. Although niraparib holds a pivotal role in the maintenance treatment of OC, its effect on suppressing metastases during primary intervention remains enigmatic. Recently, we initiated a prospective clinical study (NCT04507841) in order
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Rising Water Levels and Vegetation Shifts Drive Substantial Reductions in Methane Emissions and Carbon Dioxide Uptake in a Great Lakes Coastal Freshwater Wetland Glob. Change Biol. (IF 10.8) Pub Date : 2025-02-01 Angela Che Ing Tang, Gil Bohrer, Avni Malhotra, Justine Missik, Fausto Machado‐Silva, Inke Forbrich
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Hsa-miR-532-3p protects human decidual mesenchymal stem cells from oxidative stress in recurrent spontaneous abortion via targeting KEAP1 Redox Biol. (IF 10.7) Pub Date : 2025-02-01 Hong Zhou, Jiaxin Zhou, ShanShan Liu, Jing Niu, Jinghua Pan, Ruiman Li
Human decidual mesenchymal stem cells (hDMSCs) play crucial roles in pregnancy. The decreased resistance of hDMSCs to oxidative stress is a key factor contributing to recurrent spontaneous abortion (RSA). miRNAs have essential functions in the proliferation and apoptosis of decidual tissues. However, the miRNAs involved in regulating oxidative stress in hDMSCs remain unclear.
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Uncovering the zebrafish's intracardiac nervous system details. Lab Anim. (IF 5.9) Pub Date : 2025-02-01 Jorge Ferreira
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Rodents regain walking with deep brain stimulation. Lab Anim. (IF 5.9) Pub Date : 2025-02-01 Jorge Ferreira
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SERPINA3C as a mediator of metabolic health in offspring Nat. Metab. (IF 18.9) Pub Date : 2025-01-31 Bianca E. Suur, Emma Börgeson
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Maternal exercise prevents metabolic disorders in offspring mice through SERPINA3C Nat. Metab. (IF 18.9) Pub Date : 2025-01-31 Yang Li, Ruo-Ying Li, Jie-Ying Zhu, Min Chen, Wang-Jing Mu, Hong-Yang Luo, Shan Li, Lin-Jing Yan, Meng-Ting Yin, Xin Li, Hu-Min Chen, Liang Guo
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Dilemmas in Linking Microbial Carbon Use Efficiency With Soil Organic Carbon Dynamics Glob. Change Biol. (IF 10.8) Pub Date : 2025-01-31 Jiacong Zhou, Yiqi Luo, Ji Chen
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ROS anchor PAMPs-mediated extracellular HMGB1 self-association and its dimerization enhances pro-inflammatory signaling Redox Biol. (IF 10.7) Pub Date : 2025-01-31 Man Sup Kwak, Myeonggil Han, Yong Joon Lee, Seoyeon Choi, Jeonghwa Kim, In Ho Park, Jeon-Soo Shin
Many cellular proteins form homo- or hetero-oligomeric complexes through dimerization, and ligand oligomerization is crucial for inducing receptor oligomerization. Intermolecular disulfide bond formation is critical for protein oligomerization that regulates biological functions. HMGB1 is a nuclear protein that acts as a DAMP when secreted. HMGB1 is redox-sensitive, contains three cysteines: Cys23
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A comparative review of murine models of repeated low-dose cisplatin-induced chronic kidney disease Lab Anim. (IF 5.9) Pub Date : 2025-01-30 Hong-Wei Su, Cai-Wei Qiu
This Review evaluates various mouse and rat models of chronic kidney disease (CKD) that result from repeated low-dose cisplatin (RLDC) treatment while also discussing ethical considerations on the topic. Cisplatin can cause nephrotoxicity, and high doses of cisplatin can cause acute kidney injury. The RLDC regimen has been used in the treatment of solid organ cancers and has shown efficacy in reducing