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- Russ. J. Genet.
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-
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- J. Parasitol.
- J. Reprod. Immunol.
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- BBA Gene Regul. Mech.
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- Channels
- Clin. Biomech.
- Curr. Opin. Struc. Biol.
- Dokl. Biochem. Biophys.
- Electromagn. Biol. Med.
- Eur. Biophys. J.
- FEBS Lett.
- Food Biophys.
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- Int. J. Biometeorol.
- J. Biol. Phys.
- J. Biomech.
- Nat. Struct. Mol. Biol.
- Photochem. Photobiol.
- Phys. Biol.
- Phys. Rev. E
- Pteridines
- Q. Rev. Biophys.
- Radiat. Res.
- Structure
-
神经科学
- All
- ACS Chem. Neurosci.
- Acta Neuropathol. Commun.
- Addict. Behav.
- Aging Neuropsychol. Cognit.
- Alzheimer Dis. Assoc. Disord.
- Am. J. Alzheimers Dis. Other Demen.
- Amyotroph. Lateral Scler. Frontotemporal Degener.
- Ann. Anat.
- Ann. Indian Acad. Neurol.
- Annu. Rev. Neurosci.
- Annu. Rev. Vis. Sci.
- Aphasiology
- Arch. Ital. Biol.
- Arts Psychother.
- ASN Neuro
- Auton. Neurosci.
- BBA Gen. Subj.
- Behav. Brain Funct.
- Behav. Brain Res.
- Behav. Brain. Sci.
- Behav. Neurol.
- Behav. Neurosci.
- Biol. Cybern.
- Biol. Psychiatry
- bioRxiv. Neurosci.
- Bipolar Disord.
- BMC Neurosci.
- BMJ Neurol. Open
- Brain
- Brain Behav. Evol.
- Brain Behav. Immun.
- Brain Cognit.
- Brain Connect.
- Brain Dev.
- Brain Imaging Behav.
- Brain Inj.
- Brain Pathol.
- Brain Res.
- Brain Res. Bull.
- Brain Sci.
- Brain Stimul.
- Cell. Mol. Neurobiol.
- Cephalalgia
- Cereb. Cortex
- Chem. Percept.
- Chem. Senses
- Childs Nerv. Syst.
- Clin. EEG Neurosci.
- Clin. Neurol. Neurosurg.
- Clin. Neurophysiol.
- Clin. Neuroradiol.
- CNS Drugs
- CNS Spectr.
- Cogn. Affect. Behav. Neurosci.
- Cogn. Dev.
- Cogn. Neurodyn.
- Cogn. Neuropsychol.
- Cogn. Syst. Res.
- Cognition
- Comput. Intell. Neurosci.
- Cortex
- Curr. Alzheimer Res.
- Curr. Opin. Behav. Sci.
- Curr. Opin. Neurobiol.
- Curr. Pain Headache Rep.
- Depression Anxiety
- Dev. Cogn. Neurosci.
- Dev. Neurobiol.
- Dev. Neuropsychol.
- Dev. Neurorehabil.
- Dev. Neurosci.
- Egypt. J. Neurol. Psychiatry Neurosurg.
- Egypt. J. Neurosurg.
- Epilepsia
- Epilepsy Behav.
- Eur. J. Nerosci.
- Eur. J. Neurol.
- Eur. J. Neurosci.
- Eur. J. Paediatr. Neurol.
- Eur. Neurol.
- Exp. Brain Res.
- Exp. Neurobiol.
- Fluids Barriers CNS
- Folia Neuropathol.
- Front Hum Neurosci
- Front. Cell. Neurosci.
- Front. Comput. Neurosci.
- Front. Integr. Neurosci.
- Front. Mol. Neurosci.
- Front. Neural Circuits
- Front. Neuroanat.
- Front. Neuroinform.
- Front. Neurol.
- Front. Neurorobotics
- Front. Neurosci.
- Front. Syst. Neurosci.
- Gait Posture
- Genes Brain Behav.
- Geroscience
- Glia
- Hum. Brain Mapp.
- Int. J. Dev. Neurosci.
- Int. J. Neural Syst.
- Int. J. Neuropsychopharmacol.
- Int. J. Neurosci.
- Int. Neurourol. J.
- Invertebr. Neurosci.
- J. Alzheimer’s Dis.
- J. Atten. Disord.
- J. Behav. Decis. Mak.
- J. Cogn. Neurosci.
- J. Cognit. Dev.
- J. Comput. Neurosci.
- J. Dual Diagn.
- J. Geriatr. Psychiatry Neurol.
- J. Math. Neurosc.
- J. Mem. Lang.
- J. Mot. Behav.
- J. Neural Eng.
- J. Neural. Transm.
- J. Neurochem.
- J. Neurogenet.
- J. Neuroimmune Pharmacol.
- J. Neuroimmunol.
- J. Neurol.
- J. Neurol. Sci.
- J. Neurolinguistics
- J. Neurophysiol.
- J. Neuroradiol.
- J. Neurosci.
- J. Neurosci. Methods
- J. Neurosci. Res.
- J. Neurotrauma
- J. Neurovirol.
- J. Parkinson’s Dis.
- J. Peripher. Nerv. Syst.
- J. Pineal. Res.
- J. Spinal Cord Med.
- J. Stroke Cerebrovasc. Dis.
- Laterality
- medRxiv. Neurol.
- Metab. Brain Dis.
- Mol. Brain
- Mol. Cell. Neurosci.
- Mol. Neurobiol.
- Muscle Nerve
- Nat. Neurosci.
- Nat. Rev. Neurosci.
- Neural Comput.
- Neural Netw.
- Neural Plast.
- Neural. Dev.
- Neuro Oncol.
- Neurobiol. Aging
- Neurobiol. Learn. Mem.
- Neurobiol. Stress
- Neurochem. Int.
- Neurochem. J.
- Neurodegener. Dis.
- Neuroendocrinology
- Neurogastroenterol. Motil.
- Neurogenetics
- NeuroImage
- Neuroimage Clin.
- Neuroinformatics
- Neurol. Res.
- Neurol. Sci.
- Neuromol. Med.
- Neuromuscul. Disord.
- Neuron
- Neuropathol. Appl. Neurobiol.
- Neuropeptides
- Neurophotonics
- Neurophysiology
- Neuropsychol. Rehabilit.
- Neurorehabilit. Neural Repair
- Neurosci Biobehav Rev
- Neurosci. Bull.
- Neurosci. Lett.
- Neurosci. Res.
- Neuroscience
- Neurosurg. Rev.
- Neurosurgery
- Neurotherapeutics
- Neurotoxicol. Teratol.
- Neurotoxicology
- npj Sci. Learn.
- Pain Pract.
- Pain Res. Manag.
- Parkinson's Dis.
- Pediatr. Neurol.
- Pract. Neurol.
- Prog. Neurobiol.
- Respir. Physiol. Neurobiol.
- Rev. Neurosci.
- Schmerz
- Sleep
- Sleep Biol. Rhythm.
- Soc. Cogn. Affect. Neurosci.
- Soc. Neurosci.
- Somatosens. Mot. Res.
- Synapse
- Trans. Neurosci.
- Trends Neurosci.
-
微生物
- All
- Acta Microbiol. Immunol. Hung.
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- Acta Trop.
- Adv. Appl. Microbiol.
- Aerobiologia
- AIDS Behav.
- Am. J. Enology Vitic.
- Anaerobe
- Anim. Biotechnol.
- Ann. Clin. Microbiol. Antimicrob.
- Ann. Microbiol.
- Annu. Rev. Microbiol.
- Antibiotics
- Antimicrob. Resist. Infect. Control
- Antivir. Ther.
- Antonie van Leeuwenhoek
- APMIS
- Appl. Biochem. Microbiol.
- Appl. Environ. Microb.
- Appl. Microbiol. Biotechnol.
- Aquat. Microb. Ecol.
- Arch. Immunol. Ther. Exp.
- Arch. Microbiol.
- Arch. Virol.
- Archaea
- Biodegradation
- Biofouling
- Biologicals
- BioMed Res. Int.
- bioRxiv. Microbiol.
- Biotechnol. Prog.
- BMC Microbiol.
- Braz. J. Microbiol.
- Can. J. Infect. Dis. Med. Microbiol.
- Cell Host Microbe
- Cell. Microbiol.
- Circ. J.
- Clin. Microbiol. Rev.
- Comp. Immunol. Microbiol. Infect. Dis.
- Crit. Rev. Eukaryot. Gene Expr.
- Crit. Rev. Microbiol.
- Curr. Microbiol.
- Curr. Opin. Microbiol.
- Cytotechnology
- Diagn. Microbiol. Infect. Dis.
- Dis. Markers
- Emerg. Microbes Infect.
- Enferm. Infecc. Microbiol. Clin.
- Environ. Microbiol.
- Environ. MicroBiol. Rep
- Enzyme Microb. Technol.
- Eur. J. Clin. Microbiol. Infect. Dis.
- Eur. J. Protistol.
- Expert Opin. Biol. Ther.
- Expert Rev. Anti Infect. Ther.
- Extremophiles
- FEMS Microbiol. Ecol.
- FEMS Microbiol. Lett.
- FEMS Microbiol. Rev.
- FEMS Yeast Res.
- Folia Microbiol.
- Food Environ. Virol.
- Food Microbiol.
- Food Technol. Biotechnol.
- Front. Cell. Infect. Microbiol.
- Front. Microbiol.
- Fungal Biol.
- Fungal Biol. Rev.
- Fungal Divers.
- Fungal Genet. Biol.
- Genes Genom.
- Geobiology
- Geomicrobiol. J.
- Gut Pathog.
- Harmful Algae
- Hereditas
- IMA Fungus
- Indian J. Med. Microbiol.
- Indian J. Microbiol.
- Int. Dairy J.
- Int. J. Biol. Markers
- Int. J. Food Microbiol.
- Int. J. Genom.
- Int. J. Med. Microbiol.
- Int. Microbiol.
- Intervirology
- J. Antimicrob. Chemother.
- J. Appl. Microbiol.
- J. Bacteriol.
- J. Basic Microbiol.
- J. Biosci. Bioeng.
- J. Chem. Technol. Biotechnol.
- J. Clin. Microbiol.
- J. Eukaryot. Microbiol.
- J. Gen. Virol.
- J. Ind. Microbiol. Biotechnol.
- J. Infect. Dis.
- J. Med. Microbiol.
- J. Microbiol.
- J. Microbiol. Biotechnol.
- J. Microbiol. Immunol. Infect.
- J. Microbiol. Methods
- J. Mol. Microbiol. Biotechnol.
- J. Oral Microbiol.
- J. Parasitol.
- J. Virol. Methods
- J. Water Health
- Lab Anim.
- Lett. Appl. Microbiol.
- Mar. Micropaleontol.
- mBio
- Med. Microbiol. Immunol.
- Med. Mycol.
- Mem. Inst. Oswaldo Cruz
- Microb. Drug Resist.
- Microb. Ecol.
- Microb. Genom.
- Microb. Pathog.
- Microb. Risk Anal.
- Microbes Environ.
- Microbes Infect.
- Microbiol. Immunol.
- Microbiol. Mol. Biol. Rev.
- Microbiol. Res.
- Microbiology
- Microbiome
- Microorganisms
- Mol. Microbiol.
- Mol. Oral Microbiol.
- Mol. Plant Microbe Interact.
- Molecul. Genet. Microbiol. Virol.
- mSphere
- mSystems
- Mult. Scler. J.
- Mycobiology
- MycoKeys
- Mycologia
- Mycopathologia
- Mycoscience
- Mycoses
- Mycotoxin. Res.
- Nat. Microbiol.
- Nat. Prod. Bioprospect.
- Nat. Rev. Microbiol.
- npj Biofilms Microbiomes
- Parasite Immunol.
- Plasmid
- Probiotics Antimicrob. Proteins
- Protist
- Res. Microbiol.
- Retrovirology
- Rev. Iberoam. Micol.
- Revis. Argent. Microbiol.
- Saudi J. Biol. Sci.
- South. Afr. J. Hiv Med.
- Stand. Genomic. Sci.
- Stud. Mycol.
- Syst. Appl. Microbiol.
- Trends Microbiol.
- Tuberculosis
- Vet. Microbiol.
- Virol. J.
- Virulence
- Virus Evol.
- Virus Genes
- Virus Res.
- Viruses
- World J. Microbiol. Biotechnol.
- Yeast
-
植物
- All
- Acta Physiol. Plant.
- Alp. Botany
- Am. J. Bot.
- Ann. Appl. Biol.
- Ann. Bot.
- Annu. Rev. Phytopathol.
- Annu. Rev. Plant Biol.
- AoB Plants
- Appl. Plant Sci.
- Aquat. Bot.
- Aust. J. Bot.
- Australasian Plant Pathol.
- bioRxiv. Plant Biol.
- BMC Plant Biol.
- Bot. J. Linn. Soc.
- Bot. Lett.
- Bot. Rev.
- Bot. Stud.
- Botanica Mar.
- Botany
- Braz. J. Bot.
- Brittonia
- Bull. Entomol. Res.
- Can. J. Plant Pathol.
- Clin. Phytosci.
- Commun. Soil Sci. Plant Anal.
- Crit. Rev. Plant Sci.
- Curr. Genomics
- Curr. Opin. Plant Biol.
- Dendrochronologia
- Econ. Bot.
- Environ. Exp. Bot.
- Euphytica
- Eur. J. Phycol.
- Eur. J. Plant Pathol.
- Flora
- Folia Geobot.
- Front. Plant Sci.
- Funct. Plant Biol.
- Grana
- Horticult. Plant J.
- In Vitro Cell. Dev. Biol.-Plant
- Indian J. Tradit. Knowl.
- Int. J. Fruit Sci.
- Int. J. Plant Prod.
- Int. J. Plant Sci.
- Invasive Plant Sci. Manag.
- J. Appl. Phycol.
- J. Appl. Res. Med. Plants
- J. Berry Res.
- J. Bryol.
- J. Essent. Oil Bear. Plants
- J. Ethnobiol. Ethnomed.
- J. Exp. Bot.
- J. Gen. Plant Pathol.
- J. Integr. Plant Biol.
- J. Nat. Med.
- J. Phycol.
- J. Phytopathol.
- J. Plant Biochem. Biot.
- J. Plant Biol.
- J. Plant Dis. Prot.
- J. Plant Ecol.
- J. Plant Growth. Regul.
- J. Plant Interact.
- J. Plant Nutr.
- J. Plant Pathol.
- J. Plant Physiol.
- J. Plant Regist.
- J. Plant Res.
- Kew Bull.
- Lichenologist
- Mol. Breed.
- Mol. Plant
- Mol. Plant Microbe Interact.
- Mol. Plant Pathol.
- Mycorrhiza
- N. Z. J. Bot.
- Nat. Plants
- New Phytol.
- Nord. J. Bot.
- Perspect. Plant Ecol. Evol. Syst.
- Photosynth. Res.
- Phycol. Res.
- Physiol. Mol. Biol. Plants
- Physiol. Mol. Plant Pathol.
- Physiol. Plant
- Phytochem. Anal.
- Phytochem. Lett.
- Phytochemistry
- PhytoKeys
- Phytoparasitica
- Phytopathology
- Plant Biol.
- Plant Biosyst.
- Plant Biotech. J.
- Plant Biotechnol. Rep.
- Plant Cell
- Plant Cell Environ.
- Plant Cell Physiol.
- Plant Cell Rep.
- Plant Cell Tiss. Organ Cult.
- Plant Commun.
- Plant Direct
- Plant Dis.
- Plant Ecol.
- Plant Ecol. Divers.
- Plant Genet. Resour.
- Plant Genome
- Plant Growth Regul.
- Plant J.
- Plant Methods
- Plant Mol. Biol.
- Plant Mol. Biol. Rep.
- Plant Pathol.
- Plant Pathol. J.
- Plant Physiol.
- Plant Physiol. Biochem.
- Plant Reprod.
- Plant Sci.
- Plant Signal Behav.
- Plant Soil
- Plant Species Biol.
- Plant Syst. Evol.
- Planta
- Plants
- Rev. Palaeobot. Palynol.
- Rhizosphere
- Russ. J. Plant Physiol.
- S. Afr. J. Bot.
- Theor. Exp. Plant Physiol.
- Tree Genet. Genomes
- Trees
- Trends Plant Sci.
- Trop. Plant Pathol.
- Tropical Plant Biol.
- Weed Technol.
-
生工
- All
- ACS Biomater. Sci. Eng.
- Algal. Res.
- AMB Express
- Anim. Biotechnol.
- Ann. Biomed. Eng.
- Annu. Rev. Biomed. Eng.
- Appl. Microbiol. Biotechnol.
- Artif. Cells Nanomed. Biotechnol.
- Bio-des. Manuf.
- Bio-Medical Mater. Eng.
- Biochem. Eng. J.
- Bioeng. Transl. Med.
- Bioengineered
- Biofabrication
- Bioinspired, Biomimetic Nanobiomater.
- Biol. Control
- Biol. Trace Elem. Res.
- Biomarkers
- Biomed. Eng. Biomed. Tech.
- BioMed. Eng. OnLine
- Bioprocess Biosyst. Eng.
- Bioresour. Bioprocess.
- Biorheology
- bioRxiv. Bioeng.
- Biotech. Histochem.
- Biotechniques
- Biotechnol. Adv.
- Biotechnol. Appl. Bioc.
- Biotechnol. Bioeng.
- Biotechnol. Genet. Eng. Rev.
- Biotechnol. J.
- Biotechnol. Prog.
- BMC Biomed. Eng.
- BMC Biotechnol.
- Cardiovasc. Eng. Technol.
- Cel. Mol. Bioeng.
- CRISPR J.
- Crit. Rev. Biotechnol.
- Crit. Rev. Eukaryot. Gene Expr.
- Curr. Opin. Biotech.
- Cytotechnology
- Digit Biomark.
- Ecol. Eng.
- Eng. Life Sci.
- Food Biosci.
- Hum. Gene Ther.
- IEEE Pulse
- IEEE Trans. Biomed. Circuits Syst.
- IEEE Trans. Biomed. Eng.
- IEEE Trans. Med. Imaging
- IEEE Trans. NanoBiosci.
- IEEE Trans. Netural Syst. Rehabil. Eng.
- Int. Dairy J.
- Int. Endod. J
- Int. J. Biol. Markers
- Int. J. Numer. Method. Biomed. Eng.
- Int. Microbiol.
- J. Am. Soc. Brew. Chem.
- J. Appl. Microbiol.
- J. Biol. Eng.
- J. Biomech.
- J. Biosci. Bioeng.
- J. Biotechnol.
- J. Food Process Eng.
- J. Genet. Eng. Biotechnol.
- J. Ind. Microbiol. Biotechnol.
- J. Microbiol. Biotechnol.
- J. Microelectromech. Syst.
- J. Mol. Cell. Cardiol.
- J. Mol. Microbiol. Biotechnol.
- J. Nanobiotechnol.
- J. Tissue Eng.
- Med. Biol. Eng. Comput.
- Med. Eng. Phys.
- Metab. Eng.
- Microb. Biotechnol.
- Microb. Cell Fact.
- Mol. Biotechnol.
- Nat. Biomed. Eng.
- Nat. Biotechnol.
- Nat. Prod. Bioprospect.
- Nucleic Acid Ther.
- Pacing Clin. Electrophysiol.
- Plant Biotechnol. Rep.
- Proc. Inst. Mech. Eng. Part H J. Mech. Eng. Med.
- Protein Eng. Des. Sel.
- Regen. Ther.
- Rejuvenation Res.
- Stem Cells Int.
- Tissue Eng. Part A
- Tissue Eng. Part B Rev.
- Tissue Eng. Part C Method
- Trends Biotechnol.
-
生态
- All
- Acta Oecol.
- Afr. J. Ecol.
- African J. Range Forage Sci.
- Alcheringa
- Ann. Appl. Biol.
- Ann. Microbiol.
- Annu. Rev. Ecol. Evol. Syst.
- Annu. Rev. Physiol.
- Aquat. Microb. Ecol.
- Austral Ecol.
- Basic Appl. Ecol.
- Behav. Ecol. Sociobiol.
- Biochem. Syst. Ecol.
- Biodegradation
- Biodivers. Data J.
- Biol. Invasions
- bioRxiv. Ecol.
- Biotropica
- BMC Ecol.
- Bot. J. Linn. Soc.
- Catena
- Chem. Ecol.
- Community Ecol.
- Conserv. Biol.
- Conserv. Lett.
- Contemp. Probl. Ecol.
- Ecohealth
- Ecol. Appl.
- Ecol. Complex.
- Ecol. Econ.
- Ecol. Eng.
- Ecol. Entomol.
- Ecol. Evol.
- Ecol. Indic.
- Ecol. Lett.
- Ecol. Manag. Restor.
- Ecol. Monogr.
- Ecology
- Ecosyst. Serv.
- Ecotoxicology.
- Environ. Biol. Fish.
- Environmetrics
- Eur. J. Wildl. Res.
- Explor. Geophys.
- FEMS Microbiol. Ecol.
- Flora
- Freshw. Sci.
- Freshwater Biol.
- Front. Ecol. Environ.
- Front. Ecol. Evolut.
- Funct. Ecol.
- Fungal Ecol.
- Geobiology
- Glob. Ecol. Biogeogr.
- Glob. Ecol. Conserv.
- Grana
- Hum. Ecol. Risk Assess.
- Hydrobiologia
- Ichnos
- Insectes Soc.
- ISME J.
- J. Anim. Ecol.
- J. Chem. Ecol.
- J. Ecol.
- J. Ethnobiol. Ethnomed.
- J. Evol. Biol.
- J. Exp. Mar. Biol. Ecol.
- J. Freshw. Ecol.
- J. Insect Behav.
- J. Nat. Hist.
- J. Plant Ecol.
- J. Trop. Ecol.
- J. Vector Ecol.
- Journal of Vegetation Science
- Mammal Rev.
- Mar. Biodivers.
- Mar. Ecol.
- Methods Ecol. Evol.
- Mol. Ecol.
- Mol. Ecol. Resour.
- Mov. Ecol.
- Mycorrhiza
- Nat. Conserv.
- Nat. Ecol. Evol.
- NeoBiota
- Oecologia
- Oryx
- Palaeobio. Palaeoenv.
- Palaeogeogr. Palaeoclimatol. Palaeoecol.
- Pedobiologia
- Perspect. Ecol. Conserv.
- Perspect. Plant Ecol. Evol. Syst.
- Phycol. Res.
- Plant Soil
- Polar Res.
- Polar Sci.
- Proc. Acad. Nat. Sci. Philadelphia
- Rangel. J.
- Rev. Chilena Hist. Nat.
- Russ. J. Ecol.
- Soil Biol. Biochem.
- Theor. Ecol.
- Trends Ecol. Evol.
- Trop. Anim. Health Prod.
- Trop. Ecol.
- Urban Ecosyst.
- Virus Evol.
- Wetlands
-
其他
- All
- Acta Agric. Scand. Sect. A Anim. Sci.
- Acta Physiol.
- Acta. Ethol.
- Adv. Theory Simul.
- Afr. J. Herpetol.
- Ageing Res. Rev.
- Alcohol
- Alcohol Alcohol.
- Altern. Lab. Anim.
- Am. J. Bioethics
- Am. J. Physiol. Regul. Integr. Comp. Physiol.
- Am. J. Physiol. Renal Physiol.
- Am. J. Primatol.
- Am. Nat.
- Anim. Behav.
- Anim. Cogn.
- Anim. Conserv.
- Anim. Feed Sci. Technol.
- Anim. Health Res. Rev.
- Anim. Prod. Sci.
- Anim. Reprod. Sci.
- Anim. Sci. J.
- Animal
- Ann. Behav. Med.
- Ann. Hum. Biol.
- Ann. Paleontol.
- Annu. Rev. Anim. Biosci.
- Annu. Rev. Entomol.
- Annu. Rev. Physiol.
- Apidologie
- Appl. Anim. Behav. Sci.
- Appl. Bionics Biomech.
- Appl. Entomol. Zool.
- Appl. Physiol. Nutr. Metab.
- Appl. Psychophysiol. Biofeedback
- Appl. Sci.
- Aquat. Biol.
- Aquat. Ecosyst. Health Manag.
- Aquat. Insects
- Arch. Anim. Nutr.
- Arch. Toxicol.
- Archaeol. Anthropol. Sci.
- Archaeometry
- Arthropod Struct. Dev.
- Asian Australas. J. Anim. Sci.
- Astrobiology
- Avian Biol. Res.
- Avian Res.
- BBA Bioenerg.
- BBA Biomembr.
- Behav. Processes
- Bioacoustics
- Biocatal. Biotransform.
- Biochem. Mol. Biol. Educ.
- Biocontrol Sci. Technol.
- Biocybern. Biomed. Eng.
- Biodivers. Conserv.
- Bioelectromagnetics
- Bioenerg. Res.
- Bioinformatics
- Bioinspir. Biomim.
- Biol. Conserv.
- Biol. J. Linn. Soc.
- Biol. Philos.
- Biol. Reprod.
- Biol. Rhythm Res.
- Biom. J.
- Biomark. Res.
- Biomed. Res.
- Biometrics
- Biomicrofluidics
- Biopreserv. Biobank.
- bioRxiv. Anim. Behav. Cognit.
- bioRxiv. Bioinform.
- bioRxiv. Cancer Biol.
- bioRxiv. Dev. Biol.
- bioRxiv. Evol. Biol.
- bioRxiv. Mol. Biol.
- bioRxiv. Paleontol.
- bioRxiv. Pathol.
- bioRxiv. Pharmacol. Toxicol.
- bioRxiv. Physiol.
- bioRxiv. Sci. Commun. Educ.
- bioRxiv. Syst. Biol.
- bioRxiv. Zool.
- Biosens. Bioelectron. X
- Biostatistics
- Biotechnol. Law Rep.
- Bird Study
- Birth Defects Res.
- BMC Bioinform.
- BMC Dev. Biol.
- BMC Evol. Biol.
- BMC Zool.
- Br. J. Philos. Sci.
- Briti. J. Nutr.
- Bull. Math. Biol.
- Cancer Biol. Ther.
- Caribb. J. Sci.
- Cartilage
- Chelonian Conserv. Biol.
- Chem. Res. Toxicol.
- Chromatographia
- Chronobiol. Int.
- Comput. Biol. Med.
- Comput. Math. Method Med.
- Comput. Method Biomech. Biomed. Eng.
- Comput. Methods Programs Biomed.
- Conserv. Genet.
- Coral Reefs
- Cretac. Res.
- Cryobiology
- Curr. Opin. Insect Sci.
- Curr. Zool.
- Cytokine Growth Factor Rev.
- Database J. Biol. Databases Curation
- Dev. Dyn.
- Dev. Growth Differ.
- Development
- Diatom Res.
- Dis. Aquat. Org.
- Dis. Model Mech.
- Divers. Distrib.
- Diversity
- Domest. Anim. Endocrinol.
- Dose-Response
- Ecohydrol. Hydrobiol.
- Econ. Hum. Biol.
- Electron. J. Biotechnol.
- Emu Austral Ornithol.
- Endanger. Species Res.
- Entmol. Rev.
- Entomol. Gen.
- Entomol. Res.
- Entomol. Sci.
- Environ. Entomol.
- Environ. Exp. Bot.
- Environ. Mol. Mutagen.
- Ergonomics
- Ethology
- Eur. J. Mass Spectrom.
- Evol. Appl.
- Evol. Bioinf.
- Evol. Biol.
- Evol. Hum. Behav.
- Evol. Med. Public Health
- Evolut. Lett.
- Evolution
- Fly
- Food Bioprod. Process.
- Food Sci. Biotechnol.
- Free Radic. Res.
- Free Radical Bio. Med.
- Front. Marine Sci.
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- IBIS
- IEEE Open J. Eng. Med. Biol.
- IEEE/ACM Trans. Comput. Biol. Bioinform.
- IET Nanobiotechnol.
- ILAR J.
- In Vivo
- Indian J. Biotechnol.
- Indian J. Exp. Biol.
- Insect Conserv. Divers.
- Insect Mol. Biol.
- Insect Sci.
- Insects
- Instrum. Sci. Technol.
- Int. Biodeterior. Biodegrad.
- Int. J. Bifurcat. Chaos
- Int. J. Food Sci. Nutr.
- Int. J. Parasitol.
- Int. J. Parasitol. Drugs Drug Resist.
- Int. J. Parasitol. Parasites Wildl.
- Int. J. Radiat. Biol.
- Int. J. Solids Struct.
- Int. Rev. Hydrobiol.
- Integr. Comp. Biol.
- Integr. Zool.
- Interdiscip. Sci. Comput. Life Sci.
- Invertebr. Biol.
- Invertebr. Reprod. Dev.
- Invertebr. Syst.
- Irbm
- Ital. J. Anim. Sci.
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- J. Anim. Sci. Biotechnol.
- J. Appl. Anim. Res.
- J. Appl. Biomater. Funct. Mater.
- J. Appl. Biomech.
- J. Appl. Entomol.
- J. Appl. Ind. Math.
- J. Appl. Physiol.
- J. Appl. Physiol. Endocrinol. Metab.
- J. Appl. Physiol. Gastrointest. Liver Physiol.
- J. Appl. Poult. Res.
- J. Appl. Toxicol.
- J. Avian Biol.
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- J. Biogeogr.
- J. Bioinform. Comput. Biol.
- J. Biol. Dyn.
- J. Biol. Edu.
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- J. Crust. Biol.
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- J. Exp. Zool. Part A
- J. Field Ornithol.
- J. Fish Biol.
- J. Fish Dis.
- J. Helminthol.
- J. Hist. Biol.
- J. Hum. Evol.
- J. Ichthyol.
- J. Innov. Opt. Health Sci.
- J. Insect Physiol.
- J. Insect Sci.
- J. Insects Food Feed
- J. Int. Soc. Sports Nutr.
- J. Mammal.
- J. Mammal. Evol.
- J. Math. Biol.
- J. Mech. Med. Biol.
- J. Med. Virol.
- J. Ornithol.
- J. Photochem. Photobiol.
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- J. Plankton Res.
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- J. Proteomics
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- J. Reprod. Dev.
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- J. Syst. Palaeontol.
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- J. Trace Elem. Med. Bio.
- J. Zool.
- J. Zool. Syst. Evol. Res.
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- Nota Lepidopterol.
- Notes Rec. Royal Soc. J. History of Sci.
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- Nutr. Metab.
- OMICS
- Org. Divers. Evol.
- Organogenesis
- Organs-on-a-Chip
- Orient. Insects
- Orig. Life Evol. Biosph.
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- Palaeoworld
- Paleobiology
- Paleontol. J.
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- Phycologia
- Phys. Med. Biol.
- Physiol. Rev.
- PLoS Comput. Biol.
- Poul. Sci.
- Prion
- Proc. Jpn. Acad. Ser. B
- Prog. Lipid. Res.
- Proteins Struct. Funct. Bioinform.
- Purinergic Signal.
- Redox Biol.
- Regen. Biomater.
- Reproduction
- Russ. J. Biol. Invasions
- Russ. J. Dev. Biol.
- Russ. J. Mar. Biol.
- Sens. Actuators Rep.
- Skelet. Muscle
- Soft Robot.
- Stat. Interface
- Stress
- Stud. Hist. Philos. Sci. Part C Stud. Hist. Philos. Biol. Biomed. Sci.
- Swarm Evol. Comput.
- Swarm Intell.
- Swiss J. Palaeontol.
- Symbiosis
- Symmetry
- Syst. Biodivers.
- Syst. Biol.
- Syst. Biol. Reprod. Med.
- Syst. Control Lett.
- Syst. Entomol.
- TAXON
- Theriogenology
- Toxicol. In Vitro
- Toxicol. Lett.
- Toxicol. Res.
- Trans. R. Soc. S. Aust.
- Trends Parasitol.
- Tropic. Zool.
- Ultrasound Med. Biol.
- Vet. Parasitol.
- Vision Res.
- Weed Biol. Manag.
- Wildlife Monogr.
- WIREs Dev. Biol.
- WIREs Nanomed. Nanobiotechnol.
- Zebrafish
- Zoo Biol.
- Zool. Anz.
- Zool. J. Linn. Soc.
- Zool. Lett.
- Zool. Middle East
- Zoology
- Zoomorphology
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Circular RNA Nat. Biotechnol. (IF 36.558) Pub Date : 2021-01-11
Recent patents regarding the preparation, amplification and therapeutic use of circular RNA.
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People Nat. Biotechnol. (IF 36.558) Pub Date : 2021-01-11
Recent moves of note in and around the biotech and pharma industries.
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Hunt for improved monoclonals against coronavirus gathers pace Nat. Biotechnol. (IF 36.558) Pub Date : 2021-01-11 Ken Garber
Following mixed results in the clinic against COVID-19, antibody engineers are further optimizing SARS-CoV-2 antibodies with the aim of improving outcomes.
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First small-molecule drug targeting RNA gains momentum Nat. Biotechnol. (IF 36.558) Pub Date : 2021-01-11 Cormac Sheridan
The new drug not only is a boon for patients with spinal muscular atrophy, but also may spearhead the development of further chemical RNA modulators for a broad range of conditions.
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BTK blockers make headway in multiple sclerosis Nat. Biotechnol. (IF 36.558) Pub Date : 2021-01-11 Elie Dolgin
By targeting both arms of the immune system, not just B cells, brain-penetrant inhibitors of Bruton’s tyrosine kinase could improve on anti-CD20 therapy for patients with multiple sclerosis.
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Immersive virtual reality as a competitive training strategy for the biopharma industry Nat. Biotechnol. (IF 36.558) Pub Date : 2021-01-11 Philip Wismer; Ainara Lopez Cordoba; Sarune Baceviciute; Frederik Clauson-Kaas; Morten Otto Alexander Sommer
Immersive virtual reality simulations tailored to aspiring industry operators in biopharma manufacturing could become a cost-effective alternative to real-life training for teaching practical skills.
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An administrative fix for manufacturing process patent thickets Nat. Biotechnol. (IF 36.558) Pub Date : 2021-01-11 Arti K. Rai; W. Nicholson Price
Biosimilar manufacturing process patent applications first filed more than a year after the biologic is approved, which represent the largest source of patent assertions in biosimilar litigation, could be addressed without requiring intervention by either the courts or Congress.
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Volumetric live cell imaging with three-dimensional parallelized RESOLFT microscopy Nat. Biotechnol. (IF 36.558) Pub Date : 2021-01-11 Andreas Bodén; Francesca Pennacchietti; Giovanna Coceano; Martina Damenti; Michael Ratz; Ilaria Testa
Elucidating the volumetric architecture of organelles and molecules inside cells requires microscopy methods with a sufficiently high spatial resolution in all three dimensions. Current methods are limited by insufficient resolving power along the optical axis, long recording times and photobleaching when applied to live cell imaging. Here, we present a 3D, parallelized, reversible, saturable/switchable
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Targeting herpes simplex virus with CRISPR–Cas9 cures herpetic stromal keratitis in mice Nat. Biotechnol. (IF 36.558) Pub Date : 2021-01-11 Di Yin; Sikai Ling; Dawei Wang; Yao Dai; Hao Jiang; Xujiao Zhou; Soren R. Paludan; Jiaxu Hong; Yujia Cai
Herpes simplex virus type 1 (HSV-1) is a leading cause of infectious blindness. Current treatments for HSV-1 do not eliminate the virus from the site of infection or latent reservoirs in the trigeminal ganglia. Here, we target HSV-1 genomes directly using mRNA-carrying lentiviral particles that simultaneously deliver SpCas9 mRNA and viral-gene-targeting guide RNAs (designated HSV-1-erasing lentiviral
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ChIP-seq of plasma cell-free nucleosomes identifies gene expression programs of the cells of origin Nat. Biotechnol. (IF 36.558) Pub Date : 2021-01-11 Ronen Sadeh; Israa Sharkia; Gavriel Fialkoff; Ayelet Rahat; Jenia Gutin; Alon Chappleboim; Mor Nitzan; Ilana Fox-Fisher; Daniel Neiman; Guy Meler; Zahala Kamari; Dayana Yaish; Tamar Peretz; Ayala Hubert; Jonathan E. Cohen; Azzam Salah; Mark Temper; Albert Grinshpun; Myriam Maoz; Samir Abu-Gazala; Ami Ben Ya’acov; Eyal Shteyer; Rifaat Safadi; Tommy Kaplan; Ruth Shemer; David Planer; Eithan Galun; Benjamin
Cell-free DNA (cfDNA) in human plasma provides access to molecular information about the pathological processes in the organs or tumors from which it originates. These DNA fragments are derived from fragmented chromatin in dying cells and retain some of the cell-of-origin histone modifications. In this study, we applied chromatin immunoprecipitation of cell-free nucleosomes carrying active chromatin
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Publisher Correction: COVID-19 antibodies on trial Nat. Biotechnol. (IF 36.558) Pub Date : 2021-01-08 Laura DeFrancesco
A Correction to this paper has been published: https://doi.org/10.1038/s41587-021-00813-x.
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Left-handed DNA-PAINT for improved super-resolution imaging in the nucleus Nat. Biotechnol. (IF 36.558) Pub Date : 2021-01-04 H. J. Geertsema; G. Aimola; V. Fabricius; J. P. Fuerste; B. B. Kaufer; H. Ewers
DNA point accumulation in nanoscale topography (DNA-PAINT) increases the resolution and multiplexing capabilities of super-resolution imaging, but cellular DNA interferes with DNA–DNA hybridization between target and probe in the nucleus. Here, we introduce left-handed DNA (L-DNA) oligomers that do not hybridize to natural right-handed DNA (R-DNA) and demonstrate that L-DNA-PAINT has the same specificity
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Improved metagenome binning and assembly using deep variational autoencoders Nat. Biotechnol. (IF 36.558) Pub Date : 2021-01-04 Jakob Nybo Nissen; Joachim Johansen; Rosa Lundbye Allesøe; Casper Kaae Sønderby; Jose Juan Almagro Armenteros; Christopher Heje Grønbech; Lars Juhl Jensen; Henrik Bjørn Nielsen; Thomas Nordahl Petersen; Ole Winther; Simon Rasmussen
Despite recent advances in metagenomic binning, reconstruction of microbial species from metagenomics data remains challenging. Here we develop variational autoencoders for metagenomic binning (VAMB), a program that uses deep variational autoencoders to encode sequence coabundance and k-mer distribution information before clustering. We show that a variational autoencoder is able to integrate these
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A five-transgene cassette confers broad-spectrum resistance to a fungal rust pathogen in wheat Nat. Biotechnol. (IF 36.558) Pub Date : 2021-01-04 Ming Luo; Liqiong Xie; Soma Chakraborty; Aihua Wang; Oadi Matny; Michelle Jugovich; James A. Kolmer; Terese Richardson; Dhara Bhatt; Mohammad Hoque; Mehran Patpour; Chris Sørensen; Diana Ortiz; Peter Dodds; Burkhard Steuernagel; Brande B. H. Wulff; Narayana M. Upadhyaya; Rohit Mago; Sambasivam Periyannan; Evans Lagudah; Roger Freedman; T. Lynne Reuber; Brian J. Steffenson; Michael Ayliffe
Breeding wheat with durable resistance to the fungal pathogen Puccinia graminis f. sp. tritici (Pgt), a major threat to cereal production, is challenging due to the rapid evolution of pathogen virulence. Increased durability and broad-spectrum resistance can be achieved by introducing more than one resistance gene, but combining numerous unlinked genes by breeding is laborious. Here we generate polygenic
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Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries Nat. Biotechnol. (IF 36.558) Pub Date : 2021-01-04 Miljan Kuljanin; Dylan C. Mitchell; Devin K. Schweppe; Ajami S. Gikandi; David P. Nusinow; Nathan J. Bulloch; Ekaterina V. Vinogradova; David L. Wilson; Eric T. Kool; Joseph D. Mancias; Benjamin F. Cravatt; Steven P. Gygi
Current methods used for measuring amino acid side-chain reactivity lack the throughput needed to screen large chemical libraries for interactions across the proteome. Here we redesigned the workflow for activity-based protein profiling of reactive cysteine residues by using a smaller desthiobiotin-based probe, sample multiplexing, reduced protein starting amounts and software to boost data acquisition
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Messengers of hope Nat. Biotechnol. (IF 36.558) Pub Date : 2020-12-29
Emergency Use Authorizations for two mRNA COVID-19 vaccines represent a turning point in the pandemic. They also herald a new era for vaccinology.
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Hypertension delays viral clearance and exacerbates airway hyperinflammation in patients with COVID-19 Nat. Biotechnol. (IF 36.558) Pub Date : 2020-12-24 Saskia Trump; Soeren Lukassen; Markus S. Anker; Robert Lorenz Chua; Johannes Liebig; Loreen Thürmann; Victor Max Corman; Marco Binder; Jennifer Loske; Christina Klasa; Teresa Krieger; Bianca P. Hennig; Marey Messingschlager; Fabian Pott; Julia Kazmierski; Sven Twardziok; Jan Philipp Albrecht; Jürgen Eils; Sara Hadzibegovic; Alessia Lena; Bettina Heidecker; Thore Bürgel; Jakob Steinfeldt; Christine
In coronavirus disease 2019 (COVID-19), hypertension and cardiovascular diseases are major risk factors for critical disease progression. However, the underlying causes and the effects of the main anti-hypertensive therapies—angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs)—remain unclear. Combining clinical data (n = 144) and single-cell sequencing data of airway
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A multicenter study benchmarking single-cell RNA sequencing technologies using reference samples Nat. Biotechnol. (IF 36.558) Pub Date : 2020-12-21 Wanqiu Chen; Yongmei Zhao; Xin Chen; Zhaowei Yang; Xiaojiang Xu; Yingtao Bi; Vicky Chen; Jing Li; Hannah Choi; Ben Ernest; Bao Tran; Monika Mehta; Parimal Kumar; Andrew Farmer; Alain Mir; Urvashi Ann Mehra; Jian-Liang Li; Malcolm Moos; Wenming Xiao; Charles Wang
Comparing diverse single-cell RNA sequencing (scRNA-seq) datasets generated by different technologies and in different laboratories remains a major challenge. Here we address the need for guidance in choosing algorithms leading to accurate biological interpretations of varied data types acquired with different platforms. Using two well-characterized cellular reference samples (breast cancer cells and
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CheckV assesses the quality and completeness of metagenome-assembled viral genomes Nat. Biotechnol. (IF 36.558) Pub Date : 2020-12-21 Stephen Nayfach; Antonio Pedro Camargo; Frederik Schulz; Emiley Eloe-Fadrosh; Simon Roux; Nikos C. Kyrpides
Millions of new viral sequences have been identified from metagenomes, but the quality and completeness of these sequences vary considerably. Here we present CheckV, an automated pipeline for identifying closed viral genomes, estimating the completeness of genome fragments and removing flanking host regions from integrated proviruses. CheckV estimates completeness by comparing sequences with a large
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Author Correction: Why the European Union needs a national GMO opt-in mechanism Nat. Biotechnol. (IF 36.558) Pub Date : 2020-12-18 Dennis Eriksson; Eugénia de Andrade; Borut Bohanec; Sevasti Chatzopoulou; Roberto Defez; Nélida Leiva Eriksson; Piet van der Meer; Bernd van der Meulen; Anneli Ritala; László Sági; Joachim Schiemann; Tomasz Twardowski; Tomáš Vaněk
A correction to this paper has been published: https://doi.org/10.1038/s41587-020-00800-8
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Author Correction: Supporting US public health experts Nat. Biotechnol. (IF 36.558) Pub Date : 2020-12-17 Ron Cohen; Cedric Francois; John Crowley; Paul Hastings; Rachel King; Ted W. Love; John Maraganore; Michelle McMurry-Heath; Jeremy Levin
A Correction to this paper has been published: https://doi.org/10.1038/s41587-020-00792-5.
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Efficient hybrid de novo assembly of human genomes with WENGAN Nat. Biotechnol. (IF 36.558) Pub Date : 2020-12-14 Alex Di Genova; Elena Buena-Atienza; Stephan Ossowski; Marie-France Sagot
Generating accurate genome assemblies of large, repeat-rich human genomes has proved difficult using only long, error-prone reads, and most human genomes assembled from long reads add accurate short reads to polish the consensus sequence. Here we report an algorithm for hybrid assembly, WENGAN, that provides very high quality at low computational cost. We demonstrate de novo assembly of four human
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Chromosome-scale, haplotype-resolved assembly of human genomes Nat. Biotechnol. (IF 36.558) Pub Date : 2020-12-07 Shilpa Garg; Arkarachai Fungtammasan; Andrew Carroll; Mike Chou; Anthony Schmitt; Xiang Zhou; Stephen Mac; Paul Peluso; Emily Hatas; Jay Ghurye; Jared Maguire; Medhat Mahmoud; Haoyu Cheng; David Heller; Justin M. Zook; Tobias Moemke; Tobias Marschall; Fritz J. Sedlazeck; John Aach; Chen-Shan Chin; George M. Church; Heng Li
Haplotype-resolved or phased genome assembly provides a complete picture of genomes and their complex genetic variations. However, current algorithms for phased assembly either do not generate chromosome-scale phasing or require pedigree information, which limits their application. We present a method named diploid assembly (DipAsm) that uses long, accurate reads and long-range conformation data for
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Fully phased human genome assembly without parental data using single-cell strand sequencing and long reads Nat. Biotechnol. (IF 36.558) Pub Date : 2020-12-07 David Porubsky; Peter Ebert; Peter A. Audano; Mitchell R. Vollger; William T. Harvey; Pierre Marijon; Jana Ebler; Katherine M. Munson; Melanie Sorensen; Arvis Sulovari; Marina Haukness; Maryam Ghareghani; Peter M. Lansdorp; Benedict Paten; Scott E. Devine; Ashley D. Sanders; Charles Lee; Mark J. P. Chaisson; Jan O. Korbel; Evan E. Eichler; Tobias Marschall
Human genomes are typically assembled as consensus sequences that lack information on parental haplotypes. Here we describe a reference-free workflow for diploid de novo genome assembly that combines the chromosome-wide phasing and scaffolding capabilities of single-cell strand sequencing1,2 with continuous long-read or high-fidelity3 sequencing data. Employing this strategy, we produced a completely
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Highly sensitive spatial transcriptomics at near-cellular resolution with Slide-seqV2 Nat. Biotechnol. (IF 36.558) Pub Date : 2020-12-07 Robert R. Stickels; Evan Murray; Pawan Kumar; Jilong Li; Jamie L. Marshall; Daniela J. Di Bella; Paola Arlotta; Evan Z. Macosko; Fei Chen
Measurement of the location of molecules in tissues is essential for understanding tissue formation and function. Previously, we developed Slide-seq, a technology that enables transcriptome-wide detection of RNAs with a spatial resolution of 10 μm. Here we report Slide-seqV2, which combines improvements in library generation, bead synthesis and array indexing to reach an RNA capture efficiency ~50%
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Chimeric antigen receptors Nat. Biotechnol. (IF 36.558) Pub Date : 2020-12-03
Recent patents for methods of making and using chimeric antigen receptor (CAR) T cells to treat cancer and other diseases.
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A biotech insect repellent, safe enough to eat Nat. Biotechnol. (IF 36.558) Pub Date : 2020-12-03 Emily Waltz
The fledgling metabolic engineering industry expands its products to pest control.
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Microbial cocktails raise bar for C. diff . treatments Nat. Biotechnol. (IF 36.558) Pub Date : 2020-12-03 Mark Ratner
Seres’s success with an industrially made bacterial mix in phase 3 trials against Clostridium difficile infection promises an alternative to fecal microbial transplantation in clinical practice.
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People Nat. Biotechnol. (IF 36.558) Pub Date : 2020-12-03
Recent moves of note in and around the biotech and pharma industries.
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Specter of eye toxicity looms over BCMA-targeted therapy Nat. Biotechnol. (IF 36.558) Pub Date : 2020-12-03 Elie Dolgin
The first antibody–drug conjugate to treat multiple myeloma can spur reversible loss of vision, but that may not be the case for other anti-BCMA T-cell therapies or bispecific antibodies.
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The art of virtual mentoring in the twenty-first century for STEM majors and beyond Nat. Biotechnol. (IF 36.558) Pub Date : 2020-12-03 Melanie R. McReynolds; Christina M. Termini; Antentor O. Hinton; Brittany L. Taylor; Zer Vue; Sunny C. Huang; ReAnna S. Roby; Haysetta Shuler; Calvin S. Carter
Social quarantine has severely impacted the training of new scientists, but the use of virtual platforms can supplement mentorship, making career development seamless.
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Generation of human striatal organoids and cortico-striatal assembloids from human pluripotent stem cells Nat. Biotechnol. (IF 36.558) Pub Date : 2020-12-03 Yuki Miura; Min-Yin Li; Fikri Birey; Kazuya Ikeda; Omer Revah; Mayuri Vijay Thete; Jin-Young Park; Alyssa Puno; Samuel H. Lee; Matthew H. Porteus; Sergiu P. Pașca
Cortico-striatal projections are critical components of forebrain circuitry that regulate motivated behaviors. To enable the study of the human cortico-striatal pathway and how its dysfunction leads to neuropsychiatric disease, we developed a method to convert human pluripotent stem cells into region-specific brain organoids that resemble the developing human striatum and include electrically active
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The global chimeric antigen receptor T (CAR-T) cell therapy patent landscape Nat. Biotechnol. (IF 36.558) Pub Date : 2020-12-03 Liyang Lyu; Ye Feng; Xin Chen; Yuanjia Hu
Global patents in the field of CAR-T cell therapy show a changing landscape with fierce competition and intensive collaboration.
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The nucleotides that bind Nat. Biotechnol. (IF 36.558) Pub Date : 2020-11-30
Rapid progress is being made in our understanding of RNA–protein interactions, their role in disease and their influence on the action of oligonucleotide drugs.
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Readfish enables targeted nanopore sequencing of gigabase-sized genomes Nat. Biotechnol. (IF 36.558) Pub Date : 2020-11-30 Alexander Payne; Nadine Holmes; Thomas Clarke; Rory Munro; Bisrat J. Debebe; Matthew Loose
Nanopore sequencers can be used to selectively sequence certain DNA molecules in a pool by reversing the voltage across individual nanopores to reject specific sequences, enabling enrichment and depletion to address biological questions. Previously, we achieved this using dynamic time warping to map the signal to a reference genome, but the method required substantial computational resources and did
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A comprehensive library of human transcription factors for cell fate engineering Nat. Biotechnol. (IF 36.558) Pub Date : 2020-11-30 Alex H. M. Ng; Parastoo Khoshakhlagh; Jesus Eduardo Rojo Arias; Giovanni Pasquini; Kai Wang; Anka Swiersy; Seth L. Shipman; Evan Appleton; Kiavash Kiaee; Richie E. Kohman; Andyna Vernet; Matthew Dysart; Kathleen Leeper; Wren Saylor; Jeremy Y. Huang; Amanda Graveline; Jussi Taipale; David E. Hill; Marc Vidal; Juan M. Melero-Martin; Volker Busskamp; George M. Church
Human pluripotent stem cells (hPSCs) offer an unprecedented opportunity to model diverse cell types and tissues. To enable systematic exploration of the programming landscape mediated by transcription factors (TFs), we present the Human TFome, a comprehensive library containing 1,564 TF genes and 1,732 TF splice isoforms. By screening the library in three hPSC lines, we discovered 290 TFs, including
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Targeted nanopore sequencing by real-time mapping of raw electrical signal with UNCALLED Nat. Biotechnol. (IF 36.558) Pub Date : 2020-11-30 Sam Kovaka; Yunfan Fan; Bohan Ni; Winston Timp; Michael C. Schatz
Conventional targeted sequencing methods eliminate many of the benefits of nanopore sequencing, such as the ability to accurately detect structural variants or epigenetic modifications. The ReadUntil method allows nanopore devices to selectively eject reads from pores in real time, which could enable purely computational targeted sequencing. However, this requires rapid identification of on-target
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MPL resolves genetic linkage in fitness inference from complex evolutionary histories Nat. Biotechnol. (IF 36.558) Pub Date : 2020-11-30 Muhammad Saqib Sohail; Raymond H. Y. Louie; Matthew R. McKay; John P. Barton
Genetic linkage causes the fate of new mutations in a population to be contingent on the genetic background on which they appear. This makes it challenging to identify how individual mutations affect fitness. To overcome this challenge, we developed marginal path likelihood (MPL), a method to infer selection from evolutionary histories that resolves genetic linkage. Validation on real and simulated
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COVID-19 vaccines poised for launch, but impact on pandemic unclear Nat. Biotechnol. (IF 36.558) Pub Date : 2020-11-25 Elie Dolgin
The race to bring vaccines to market is nearing the finish line. Determining which product can best contain the pandemic, however, will take more time.
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Author Correction: Integrating microarray-based spatial transcriptomics and single-cell RNA-seq reveals tissue architecture in pancreatic ductal adenocarcinomas Nat. Biotechnol. (IF 36.558) Pub Date : 2020-11-23 Reuben Moncada; Dalia Barkley; Florian Wagner; Marta Chiodin; Joseph C. Devlin; Maayan Baron; Cristina H. Hajdu; Diane M. Simeone; Itai Yanai
A Correction to this paper has been published: https://doi.org/10.1038/s41587-019-0392-8.
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CRISPR RNA-guided integrases for high-efficiency, multiplexed bacterial genome engineering Nat. Biotechnol. (IF 36.558) Pub Date : 2020-11-23 Phuc Leo H. Vo; Carlotta Ronda; Sanne E. Klompe; Ethan E. Chen; Christopher Acree; Harris H. Wang; Samuel H. Sternberg
Existing technologies for site-specific integration of kilobase-sized DNA sequences in bacteria are limited by low efficiency, a reliance on recombination, the need for multiple vectors, and challenges in multiplexing. To address these shortcomings, we introduce a substantially improved version of our previously reported Tn7-like transposon from Vibrio cholerae, which uses a Type I-F CRISPR–Cas system
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Systematic classification of unknown metabolites using high-resolution fragmentation mass spectra Nat. Biotechnol. (IF 36.558) Pub Date : 2020-11-23 Kai Dührkop; Louis-Félix Nothias; Markus Fleischauer; Raphael Reher; Marcus Ludwig; Martin A. Hoffmann; Daniel Petras; William H. Gerwick; Juho Rousu; Pieter C. Dorrestein; Sebastian Böcker
Metabolomics using nontargeted tandem mass spectrometry can detect thousands of molecules in a biological sample. However, structural molecule annotation is limited to structures present in libraries or databases, restricting analysis and interpretation of experimental data. Here we describe CANOPUS (class assignment and ontology prediction using mass spectrometry), a computational tool for systematic
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Publisher Correction: A genomic catalog of Earth’s microbiomes Nat. Biotechnol. (IF 36.558) Pub Date : 2020-11-18 Stephen Nayfach; Simon Roux; Rekha Seshadri; Daniel Udwary; Neha Varghese; Frederik Schulz; Dongying Wu; David Paez-Espino; I-Min Chen; Marcel Huntemann; Krishna Palaniappan; Joshua Ladau; Supratim Mukherjee; T. B. K. Reddy; Torben Nielsen; Edward Kirton; José P. Faria; Janaka N. Edirisinghe; Christopher S. Henry; Sean P. Jungbluth; Dylan Chivian; Paramvir Dehal; Elisha M. Wood-Charlson; Adam P. Arkin;
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Safety questions for AAV gene therapy Nat. Biotechnol. (IF 36.558) Pub Date : 2020-11-16 Charles P. Venditti
A long-term study of AAV therapy in dogs finds clonal expansions and vector integrations.
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Identification of highly selective covalent inhibitors by phage display Nat. Biotechnol. (IF 36.558) Pub Date : 2020-11-16 Shiyu Chen; Scott Lovell; Sumin Lee; Matthias Fellner; Peter D. Mace; Matthew Bogyo
Molecules that covalently bind macromolecular targets have found widespread applications as activity-based probes and as irreversibly binding drugs. However, the general reactivity of the electrophiles needed for covalent bond formation makes control of selectivity difficult. There is currently no rapid, unbiased screening method to identify new classes of covalent inhibitors from highly diverse pools
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A long-term study of AAV gene therapy in dogs with hemophilia A identifies clonal expansions of transduced liver cells Nat. Biotechnol. (IF 36.558) Pub Date : 2020-11-16 Giang N. Nguyen; John K. Everett; Samita Kafle; Aoife M. Roche; Hayley E. Raymond; Jacob Leiby; Christian Wood; Charles-Antoine Assenmacher; Elizabeth P. Merricks; C. Tyler Long; Haig H. Kazazian; Timothy C. Nichols; Frederic D. Bushman; Denise E. Sabatino
Nine dogs with hemophilia A were treated with adeno-associated viral (AAV) gene therapy and followed for up to 10 years. Administration of AAV8 or AAV9 vectors expressing canine factor VIII (AAV-cFVIII) corrected the FVIII deficiency to 1.9–11.3% of normal FVIII levels. In two of nine dogs, levels of FVIII activity increased gradually starting about 4 years after treatment. None of the dogs showed
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Author Correction: Determination of isoform-specific RNA structure with nanopore long reads Nat. Biotechnol. (IF 36.558) Pub Date : 2020-11-12 Jong Ghut Ashley Aw; Shaun W. Lim; Jia Xu Wang; Finnlay R. P. Lambert; Wen Ting Tan; Yang Shen; Yu Zhang; Pornchai Kaewsapsak; Chenhao Li; Sarah B. Ng; Leah A. Vardy; Meng How Tan; Niranjan Nagarajan; Yue Wan
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Send in the senolytics Nat. Biotechnol. (IF 36.558) Pub Date : 2020-11-12 Elie Dolgin
Despite early failures in the clinic, the idea of anti-aging therapies that purge the body of dying cells is gaining traction with a raft of startups now focused on senescence.
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Generation of paternal haploids in wheat by genome editing of the centromeric histone CENH3 Nat. Biotechnol. (IF 36.558) Pub Date : 2020-11-09 Jian Lv; Kun Yu; Juan Wei; Huaping Gui; Chunxia Liu; Dawei Liang; Yanli Wang; Hongju Zhou; Ryan Carlin; Randy Rich; Tiancong Lu; Qiudeng Que; Wen Chung Wang; Xingping Zhang; Tim Kelliher
New breeding technologies accelerate germplasm improvement and reduce the cost of goods in seed production1,2,3. Many such technologies could use in vivo paternal haploid induction (HI), which occurs when double fertilization precedes maternal (egg cell) genome loss. Engineering of the essential CENTROMERIC HISTONE (CENH3) gene induces paternal HI in Arabidopsis4,5,6. Despite conservation of CENH3
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A genomic catalog of Earth’s microbiomes Nat. Biotechnol. (IF 36.558) Pub Date : 2020-11-09 Stephen Nayfach; Simon Roux; Rekha Seshadri; Daniel Udwary; Neha Varghese; Frederik Schulz; Dongying Wu; David Paez-Espino; I-Min Chen; Marcel Huntemann; Krishna Palaniappan; Joshua Ladau; Supratim Mukherjee; T. B. K. Reddy; Torben Nielsen; Edward Kirton; José P. Faria; Janaka N. Edirisinghe; Christopher S. Henry; Sean P. Jungbluth; Dylan Chivian; Paramvir Dehal; Elisha M. Wood-Charlson; Adam P. Arkin;
The reconstruction of bacterial and archaeal genomes from shotgun metagenomes has enabled insights into the ecology and evolution of environmental and host-associated microbiomes. Here we applied this approach to >10,000 metagenomes collected from diverse habitats covering all of Earth’s continents and oceans, including metagenomes from human and animal hosts, engineered environments, and natural and
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Auto-deconvolution and molecular networking of gas chromatography–mass spectrometry data Nat. Biotechnol. (IF 36.558) Pub Date : 2020-11-09 Alexander A. Aksenov; Ivan Laponogov; Zheng Zhang; Sophie L. F. Doran; Ilaria Belluomo; Dennis Veselkov; Wout Bittremieux; Louis Felix Nothias; Mélissa Nothias-Esposito; Katherine N. Maloney; Biswapriya B. Misra; Alexey V. Melnik; Aleksandr Smirnov; Xiuxia Du; Kenneth L. Jones; Kathleen Dorrestein; Morgan Panitchpakdi; Madeleine Ernst; Justin J. J. van der Hooft; Mabel Gonzalez; Chiara Carazzone; Adolfo
We engineered a machine learning approach, MSHub, to enable auto-deconvolution of gas chromatography–mass spectrometry (GC–MS) data. We then designed workflows to enable the community to store, process, share, annotate, compare and perform molecular networking of GC–MS data within the Global Natural Product Social (GNPS) Molecular Networking analysis platform. MSHub/GNPS performs auto-deconvolution
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Coronavirus testing finally gathers speed Nat. Biotechnol. (IF 36.558) Pub Date : 2020-11-05 Cormac Sheridan
The imminent large-scale rollout of rapid coronavirus tests promises to aid public health responses to COVID-19 — but a rapid home test remains elusive.
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Third-quarter biotech job picture Nat. Biotechnol. (IF 36.558) Pub Date : 2020-11-03 Michael Francisco
A quarterly snapshot of job expansions, reductions and availability in the biotech and pharma sectors.
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First video game to treat disease gains FDA okay Nat. Biotechnol. (IF 36.558) Pub Date : 2020-11-03 Emily Waltz
The prescription-only game is said to improve attention function in children with attention deficit hyperactivity disorder (ADHD).
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Single-cell analysis and microfluidics Nat. Biotechnol. (IF 36.558) Pub Date : 2020-11-03
Recent patents related to microfluidic devices and methods for single-cell analysis.
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IRAK4 degrader to take on innate immunity Nat. Biotechnol. (IF 36.558) Pub Date : 2020-11-03 Asher Mullard
Interest in anti-inflammatory IRAK4 signaling is ramping up, as small-molecule ‘degraders’ that bind both the kinase and E3 ubiquitin ligases prepare to take on traditional kinase inhibitors.
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People Nat. Biotechnol. (IF 36.558) Pub Date : 2020-11-03
Recent moves of note in and around the biotech and pharma industries.
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Big pharma buys into exosomes for drug delivery Nat. Biotechnol. (IF 36.558) Pub Date : 2020-11-03 Mark Zipkin
Several pharmaceutical companies are placing big bets on exosomes and other extracellular vesicles as a means to deliver nucleic acid therapeutics.
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A qualitative study of biosimilar manufacturer and regulator perceptions on intellectual property and abbreviated approval pathways Nat. Biotechnol. (IF 36.558) Pub Date : 2020-11-03 Louise C. Druedahl; Anna Birna Almarsdóttir; Sofia Kälvemark Sporrong; Marie Louise De Bruin; Hans Hoogland; Timo Minssen; Marco van de Weert; Aaron S. Kesselheim; Ameet Sarpatwari
Abbreviated regulatory approval pathways for biosimilars were created to accommodate intellectual property protection, foster competition and lower drug prices, but their success in achieving these goals has been mixed.
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Preparing for the vaccine Nat. Biotechnol. (IF 36.558) Pub Date : 2020-10-27
Clear and consistent messaging on COVID-19 vaccine rollout will be key to building public trust and managing expectations.