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The case for biotech on Mars Nat. Biotechnol. (IF 31.864) Pub Date : 2020-04-01 Shannon N. Nangle; Mikhail Y. Wolfson; Lucas Hartsough; Natalie J. Ma; Christopher E. Mason; Massimo Merighi; Vinitra Nathan; Pamela A. Silver; Mark Simon; Jacob Swett; David B. Thompson; Marika Ziesack
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High-throughput single-cell activity-based screening and sequencing of antibodies using droplet microfluidics Nat. Biotechnol. (IF 31.864) Pub Date : 2020-03-30 Annabelle Gérard; Adam Woolfe; Guillaume Mottet; Marcel Reichen; Carlos Castrillon; Vera Menrath; Sami Ellouze; Adeline Poitou; Raphaël Doineau; Luis Briseno-Roa; Pablo Canales-Herrerias; Pascaline Mary; Gregory Rose; Charina Ortega; Matthieu Delincé; Sosthene Essono; Bin Jia; Bruno Iannascoli; Odile Richard-Le Goff; Roshan Kumar; Samantha N. Stewart; Yannick Pousse; Bingqing Shen; Kevin Grosselin;
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Combinatorial single-cell CRISPR screens by direct guide RNA capture and targeted sequencing Nat. Biotechnol. (IF 31.864) Pub Date : 2020-03-30 Joseph M. Replogle; Thomas M. Norman; Albert Xu; Jeffrey A. Hussmann; Jin Chen; J. Zachery Cogan; Elliott J. Meer; Jessica M. Terry; Daniel P. Riordan; Niranjan Srinivas; Ian T. Fiddes; Joseph G. Arthur; Luigi J. Alvarado; Katherine A. Pfeiffer; Tarjei S. Mikkelsen; Jonathan S. Weissman; Britt Adamson
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Genetic circuit design automation for the gut resident species Bacteroides thetaiotaomicron Nat. Biotechnol. (IF 31.864) Pub Date : 2020-03-30 Mao Taketani; Jianbo Zhang; Shuyi Zhang; Alexander J. Triassi; Yu-Ja Huang; Linda G. Griffith; Christopher A. Voigt
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What would responsible remedial human germline editing look like? Nat. Biotechnol. (IF 31.864) Pub Date : 2020-03-25 Eli Y. Adashi; I. Glenn Cohen
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Human chimeric antigen receptor macrophages for cancer immunotherapy Nat. Biotechnol. (IF 31.864) Pub Date : 2020-03-23 Michael Klichinsky; Marco Ruella; Olga Shestova; Xueqing Maggie Lu; Andrew Best; Martha Zeeman; Maggie Schmierer; Konrad Gabrusiewicz; Nicholas R. Anderson; Nicholas E. Petty; Katherine D. Cummins; Feng Shen; Xinhe Shan; Kimberly Veliz; Kristin Blouch; Yumi Yashiro-Ohtani; Saad S. Kenderian; Miriam Y. Kim; Roddy S. O’Connor; Stephen R. Wallace; Miroslaw S. Kozlowski; Dylan M. Marchione; Maksim Shestov;
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Publisher Correction: MEMOTE for standardized genome-scale metabolic model testing Nat. Biotechnol. (IF 31.864) Pub Date : 2020-03-19 Christian Lieven; Moritz E. Beber; Brett G. Olivier; Frank T. Bergmann; Meric Ataman; Parizad Babaei; Jennifer A. Bartell; Lars M. Blank; Siddharth Chauhan; Kevin Correia; Christian Diener; Andreas Dräger; Birgitta E. Ebert; Janaka N. Edirisinghe; José P. Faria; Adam M. Feist; Georgios Fengos; Ronan M. T. Fleming; Beatriz García-Jiménez; Vassily Hatzimanikatis; Wout van Helvoirt; Christopher S. Henry;
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Predicting antidepressant response by electroencephalography Nat. Biotechnol. (IF 31.864) Pub Date : 2020-03-17 Christoph M. Michel; Alvaro Pascual-Leone
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Publisher Correction: ChromID identifies the protein interactome at chromatin marks Nat. Biotechnol. (IF 31.864) Pub Date : 2020-03-17 Rodrigo Villaseñor; Ramon Pfaendler; Christina Ambrosi; Stefan Butz; Sara Giuliani; Elana Bryan; Thomas W. Sheahan; Annika L. Gable; Nina Schmolka; Massimiliano Manzo; Joël Wirz; Christian Feller; Christian von Mering; Ruedi Aebersold; Philipp Voigt; Tuncay Baubec
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Massively parallel Cas13 screens reveal principles for guide RNA design Nat. Biotechnol. (IF 31.864) Pub Date : 2020-03-16 Hans-Hermann Wessels; Alejandro Méndez-Mancilla; Xinyi Guo; Mateusz Legut; Zharko Daniloski; Neville E. Sanjana
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Prime genome editing in rice and wheat Nat. Biotechnol. (IF 31.864) Pub Date : 2020-03-16 Qiupeng Lin; Yuan Zong; Chenxiao Xue; Shengxing Wang; Shuai Jin; Zixu Zhu; Yanpeng Wang; Andrew V. Anzalone; Aditya Raguram; Jordan L. Doman; David R. Liu; Caixia Gao
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Phage-assisted evolution of an adenine base editor with improved Cas domain compatibility and activity Nat. Biotechnol. (IF 31.864) Pub Date : 2020-03-16 Michelle F. Richter; Kevin T. Zhao; Elliot Eton; Audrone Lapinaite; Gregory A. Newby; Benjamin W. Thuronyi; Christopher Wilson; Luke W. Koblan; Jing Zeng; Daniel E. Bauer; Jennifer A. Doudna; David R. Liu
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Genetic interaction mapping and exon-resolution functional genomics with a hybrid Cas9–Cas12a platform Nat. Biotechnol. (IF 31.864) Pub Date : 2020-03-16 Thomas Gonatopoulos-Pournatzis; Michael Aregger; Kevin R. Brown; Shaghayegh Farhangmehr; Ulrich Braunschweig; Henry N. Ward; Kevin C. H. Ha; Alexander Weiss; Maximilian Billmann; Tanja Durbic; Chad L. Myers; Benjamin J. Blencowe; Jason Moffat
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Massively parallel interrogation and mining of natively paired human TCRαβ repertoires Nat. Biotechnol. (IF 31.864) Pub Date : 2020-03-16 Matthew J. Spindler; Ayla L. Nelson; Ellen K. Wagner; Natasha Oppermans; John S. Bridgeman; James M. Heather; Adam S. Adler; Michael A. Asensio; Robert C. Edgar; Yoong Wearn Lim; Everett H. Meyer; Robert E. Hawkins; Mark Cobbold; David S. Johnson
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Publisher Correction: Engineering bacterial symbionts of nematodes improves their biocontrol potential to counter the western corn rootworm Nat. Biotechnol. (IF 31.864) Pub Date : 2020-03-12 Ricardo A. R. Machado; Lisa Thönen; Carla C. M. Arce; Vanitha Theepan; Fausto Prada; Daniel Wüthrich; Christelle A. M. Robert; Evangelia Vogiatzaki; Yi-Ming Shi; Olivier P. Schaeren; Matheus Notter; Rémy Bruggmann; Siegfried Hapfelmeier; Helge B. Bode; Matthias Erb
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Superior field performance of waxy corn engineered using CRISPR–Cas9 Nat. Biotechnol. (IF 31.864) Pub Date : 2020-03-09 Huirong Gao; Mark J. Gadlage; H. Renee Lafitte; Brian Lenderts; Meizhu Yang; Megan Schroder; Jeffry Farrell; Kay Snopek; Dave Peterson; Lanie Feigenbutz; Spencer Jones; Grace St Clair; Melissa Rahe; Nathalie Sanyour-Doyel; Chenna Peng; Lijuan Wang; Joshua K. Young; Mary Beatty; Brian Dahlke; Jan Hazebroek; Thomas W. Greene; A. Mark Cigan; N. Doane Chilcoat; R. Bob Meeley
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Making the best of Brexit Nat. Biotechnol. (IF 31.864) Pub Date : 2020-03-09
In the post-Brexit era, Britain must rapidly harmonize national and European law, secure unfettered access to global talent and address funding shortfalls to ensure continued leadership in the life sciences.
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Dissecting cellular crosstalk by sequencing physically interacting cells Nat. Biotechnol. (IF 31.864) Pub Date : 2020-03-09 Amir Giladi; Merav Cohen; Chiara Medaglia; Yael Baran; Baoguo Li; Mor Zada; Pierre Bost; Ronnie Blecher-Gonen; Tomer-Meir Salame; Johannes U. Mayer; Eyal David; Franca Ronchese; Amos Tanay; Ido Amit
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Neuroengineering Nat. Biotechnol. (IF 31.864) Pub Date : 2020-03-09
Recent patents related to methods of transcranial magnetic and electrostimulation.
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One year after Vanda , are diagnostics patents transforming into methods of treatment to overcome Mayo -based rejections? Nat. Biotechnol. (IF 31.864) Pub Date : 2020-03-09 Mateo Aboy; Cristina Crespo; Kathleen Liddell; Neil Davey; Johnathon Liddicoat; Timo Minssen
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Author Correction: Reply to: Fitness effects of CRISPR/Cas9-targeting of long noncoding RNA genes Nat. Biotechnol. (IF 31.864) Pub Date : 2020-03-09 Ying Liu; Zhiheng Liu; Zhongzheng Cao; Wensheng Wei
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Author Correction: Using GlycoDelete to produce proteins lacking plant-specific N -glycan modification in seeds Nat. Biotechnol. (IF 31.864) Pub Date : 2020-03-05 Robin Piron; Francis Santens; Annelies De Paepe; Ann Depicker; Nico Callewaert
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Author Correction: Template plasmid integration in germline genome-edited cattle Nat. Biotechnol. (IF 31.864) Pub Date : 2020-03-05 Alexis L. Norris; Stella S. Lee; Kevin J. Greenlees; Daniel A. Tadesse; Mayumi F. Miller; Heather A. Lombardi
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Understanding the basics of patenting Nat. Biotechnol. (IF 31.864) Pub Date : 2020-03-04 Sadhana Chitale; Colm Lawler; Scott Macfarlane
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Author Correction: A computationally designed chimeric antigen receptor provides a small-molecule safety switch for T-cell therapy. Nat. Biotechnol. (IF 31.864) Pub Date : 2020-03-03 Greta Giordano-Attianese,Pablo Gainza,Elise Gray-Gaillard,Elisabetta Cribioli,Sailan Shui,Seonghoon Kim,Mi-Jeong Kwak,Sabrina Vollers,Angel De Jesus Corria Osorio,Patrick Reichenbach,Jaume Bonet,Byung-Ha Oh,Melita Irving,George Coukos,Bruno E Correia
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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ChromID identifies the protein interactome at chromatin marks. Nat. Biotechnol. (IF 31.864) Pub Date : 2020-03-02 Rodrigo Villaseñor,Ramon Pfaendler,Christina Ambrosi,Stefan Butz,Sara Giuliani,Elana Bryan,Thomas W Sheahan,Annika L Gable,Nina Schmolka,Massimiliano Manzo,Joël Wirz,Christian Feller,Christian von Mering,Ruedi Aebersold,Philipp Voigt,Tuncay Baubec
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MEMOTE for standardized genome-scale metabolic model testing. Nat. Biotechnol. (IF 31.864) Pub Date : 2020-03-02 Christian Lieven,Moritz E Beber,Brett G Olivier,Frank T Bergmann,Meric Ataman,Parizad Babaei,Jennifer A Bartell,Lars M Blank,Siddharth Chauhan,Kevin Correia,Christian Diener,Andreas Dräger,Birgitta E Ebert,Janaka N Edirisinghe,José P Faria,Adam M Feist,Georgios Fengos,Ronan M T Fleming,Beatriz García-Jiménez,Vassily Hatzimanikatis,Wout van Helvoirt,Christopher S Henry,Henning Hermjakob,Markus J Herrgård
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Generation of human endothelium in pig embryos deficient in ETV2 Nat. Biotechnol. (IF 31.864) Pub Date : 2020-02-24 Satyabrata Das; Naoko Koyano-Nakagawa; Ohad Gafni; Geunho Maeng; Bhairab N. Singh; Tara Rasmussen; Xiaoyan Pan; Kyung-Dal Choi; Daniel Mickelson; Wuming Gong; Pruthvi Pota; Cyprian V. Weaver; Stefan Kren; Jacob H. Hanna; Demetris Yannopoulos; Mary G. Garry; Daniel J. Garry
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Publisher Correction: OpenSWATH enables automated, targeted analysis of data-independent acquisition MS data Nat. Biotechnol. (IF 31.864) Pub Date : 2020-02-24 Hannes L. Röst; George Rosenberger; Pedro Navarro; Ludovic Gillet; Saša M. Miladinović; Olga T. Schubert; Witold Wolski; Ben C. Collins; Johan Malmström; Lars Malmström; Ruedi Aebersold
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Fitness effects of CRISPR/Cas9-targeting of long noncoding RNA genes Nat. Biotechnol. (IF 31.864) Pub Date : 2020-02-24 Max A. Horlbeck; S. John Liu; Howard Y. Chang; Daniel A. Lim; Jonathan S. Weissman
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Targeting the cytoskeleton to direct pancreatic differentiation of human pluripotent stem cells. Nat. Biotechnol. (IF 31.864) Pub Date : 2020-02-24 Nathaniel J Hogrebe,Punn Augsornworawat,Kristina G Maxwell,Leonardo Velazco-Cruz,Jeffrey R Millman
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Engineering bacterial symbionts of nematodes improves biocontrol potential of the western corn rootworm. Nat. Biotechnol. (IF 31.864) Pub Date : 2020-02-17 Ricardo A R Machado,Lisa Thönen,Carla C M Arce,Vanitha Theepan,Fausto Prada,Daniel Wüthrich,Christelle A M Robert,Evangelia Vogiatzaki,Yi-Ming Shi,Olivier P Schaeren,Matheus Notter,Rémy Bruggmann,Siegfried Hapfelmeier,Helge B Bode,Matthias Erb
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Retraction Note: Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice. Nat. Biotechnol. (IF 31.864) Pub Date : 2020-02-17 Luc Baeyens,Marie Lemper,Gunter Leuckx,Sofie De Groef,Paola Bonfanti,Geert Stangé,Ruth Shemer,Christoffer Nord,David W Scheel,Fong C Pan,Ulf Ahlgren,Guoqiang Gu,Doris A Stoffers,Yuval Dor,Jorge Ferrer,Gerard Gradwohl,Christopher V E Wright,Mark Van de Casteele,Michael S German,Luc Bouwens,Harry Heimberg
This article has been retracted; see accompanying Retraction Note, which can be accessed via a link at the top of the paper.
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The nf-core framework for community-curated bioinformatics pipelines. Nat. Biotechnol. (IF 31.864) Pub Date : 2020-02-13 Philip A Ewels,Alexander Peltzer,Sven Fillinger,Harshil Patel,Johannes Alneberg,Andreas Wilm,Maxime Ulysse Garcia,Paolo Di Tommaso,Sven Nahnsen
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Deciphering the human phosphoproteome. Nat. Biotechnol. (IF 31.864) Pub Date : 2020-02-13 Giulia Franciosa,Ana Martinez-Val,Jesper V Olsen
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Publisher Correction: Butler enables rapid cloud-based analysis of thousands of human genomes. Nat. Biotechnol. (IF 31.864) Pub Date : 2020-02-12 Sergei Yakneen,Sebastian M Waszak,,Michael Gertz,Jan O Korbel,
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Complete, closed bacterial genomes from microbiomes using nanopore sequencing. Nat. Biotechnol. (IF 31.864) Pub Date : 2020-02-10 Eli L Moss,Dylan G Maghini,Ami S Bhatt
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Antibody-mediated delivery of viral epitopes to tumors harnesses CMV-specific T cells for cancer therapy. Nat. Biotechnol. (IF 31.864) Pub Date : 2020-02-10 David G Millar,Rakesh R Ramjiawan,Kosuke Kawaguchi,Nisha Gupta,Jiang Chen,Songfa Zhang,Takashi Nojiri,William W Ho,Shuichi Aoki,Keehoon Jung,Ivy Chen,Feng Shi,James M Heather,Kohei Shigeta,Laura T Morton,Sean Sepulveda,Li Wan,Ricky Joseph,Eleanor Minogue,Ashok Khatri,Aditya Bardia,Leif W Ellisen,Ryan B Corcoran,Aaron N Hata,Sara I Pai,Rakesh K Jain,Dai Fukumura,Dan G Duda,Mark Cobbold
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Targeted nanopore sequencing with Cas9-guided adapter ligation. Nat. Biotechnol. (IF 31.864) Pub Date : 2020-02-10 Timothy Gilpatrick,Isac Lee,James E Graham,Etienne Raimondeau,Rebecca Bowen,Andrew Heron,Bradley Downs,Saraswati Sukumar,Fritz J Sedlazeck,Winston Timp
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Evaluation and minimization of Cas9-independent off-target DNA editing by cytosine base editors. Nat. Biotechnol. (IF 31.864) Pub Date : 2020-02-10 Jordan L Doman,Aditya Raguram,Gregory A Newby,David R Liu
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An electroencephalographic signature predicts antidepressant response in major depression. Nat. Biotechnol. (IF 31.864) Pub Date : 2020-02-10 Wei Wu,Yu Zhang,Jing Jiang,Molly V Lucas,Gregory A Fonzo,Camarin E Rolle,Crystal Cooper,Cherise Chin-Fatt,Noralie Krepel,Carena A Cornelssen,Rachael Wright,Russell T Toll,Hersh M Trivedi,Karen Monuszko,Trevor L Caudle,Kamron Sarhadi,Manish K Jha,Joseph M Trombello,Thilo Deckersbach,Phil Adams,Patrick J McGrath,Myrna M Weissman,Maurizio Fava,Diego A Pizzagalli,Martijn Arns,Madhukar H Trivedi,Amit Etkin
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Continuous evolution of SpCas9 variants compatible with non-G PAMs. Nat. Biotechnol. (IF 31.864) Pub Date : 2020-02-10 Shannon M Miller,Tina Wang,Peyton B Randolph,Mandana Arbab,Max W Shen,Tony P Huang,Zaneta Matuszek,Gregory A Newby,Holly A Rees,David R Liu
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Emerging patent landscape for non-viral vectors used for gene therapy. Nat. Biotechnol. (IF 31.864) Pub Date : 2020-02-01 Virginia Picanço-Castro,Cristiano Gonçalves Pereira,Dimas Tadeu Covas,Geciane Silveira Porto,Aglaia Athanassiadou,Marxa Leão Figueiredo
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Genome editing in animals: why FDA regulation matters. Nat. Biotechnol. (IF 31.864) Pub Date : 2020-02-01 Steven M Solomon
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Lysosomes. Nat. Biotechnol. (IF 31.864) Pub Date : 2020-02-01
Recent patents related to lysosome-targeted therapeutics and methods of screening and visualization.
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Fourth-quarter biotech job picture. Nat. Biotechnol. (IF 31.864) Pub Date : 2020-02-01 Michael Francisco
A quarterly snapshot of job expansions, reductions and availability in the biotech and pharma sectors.
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Course correction. Nat. Biotechnol. (IF 31.864) Pub Date : 2020-02-01
The US Food and Drug Administration is sticking to its plan to carry out mandatory premarket review of all gene-edited livestock, irrespective of trait risk. It should rethink.
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Template plasmid integration in germline genome-edited cattle. Nat. Biotechnol. (IF 31.864) Pub Date : 2020-02-07 Alexis L Norris,Stella S Lee,Kevin J Greenlees,Daniel A Tadesse,Mayumi F Miller,Heather A Lombardi
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Butler enables rapid cloud-based analysis of thousands of human genomes. Nat. Biotechnol. (IF 31.864) Pub Date : 2020-02-05 Sergei Yakneen,Sebastian M Waszak,,Michael Gertz,Jan O Korbel,
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