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Nature Biotech’s top 10 stories of 2019 Nat. Biotechnol. (IF 31.864) Pub Date :
Our 10 most read news articles in 2019. Discover what drew in our readers: from STING to phages, and what's next after CRISPR.
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Droplet scRNA-seq is not zero-inflated Nat. Biotechnol. (IF 31.864) Pub Date : 2020-01-14 Valentine Svensson
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Vertical farms bear fruit Nat. Biotechnol. (IF 31.864) Pub Date : 2020-01-14 Cathryn A. O’Sullivan; C. Lynne McIntyre; Ian B. Dry; Susan M. Hani; Zvi Hochman; Graham D. Bonnett
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Targeted, random mutagenesis of plant genes with dual cytosine and adenine base editors Nat. Biotechnol. (IF 31.864) Pub Date : 2020-01-13 Chao Li; Rui Zhang; Xiangbing Meng; Sha Chen; Yuan Zong; Chunju Lu; Jin-Long Qiu; Yu-Hang Chen; Jiayang Li; Caixia Gao
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An engineered enzyme that targets circulating lactate to alleviate intracellular NADH:NAD + imbalance Nat. Biotechnol. (IF 31.864) Pub Date : 2020-01-13 Anupam Patgiri; Owen S. Skinner; Yusuke Miyazaki; Grigorij Schleifer; Eizo Marutani; Hardik Shah; Rohit Sharma; Russell P. Goodman; Tsz-Leung To; Xiaoyan Robert Bao; Fumito Ichinose; Warren M. Zapol; Vamsi K. Mootha
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Peptide–TLR-7/8a conjugate vaccines chemically programmed for nanoparticle self-assembly enhance CD8 T-cell immunity to tumor antigens Nat. Biotechnol. (IF 31.864) Pub Date : 2020-01-13 Geoffrey M. Lynn; Christine Sedlik; Faezzah Baharom; Yaling Zhu; Ramiro A. Ramirez-Valdez; Vincent L. Coble; Kennedy Tobin; Sarah R. Nichols; Yaakov Itzkowitz; Neeha Zaidi; Joshua M. Gammon; Nicolas J. Blobel; Jordan Denizeau; Philippe de la Rochere; Brian J. Francica; Brennan Decker; Mateusz Maciejewski; Justin Cheung; Hidehiro Yamane; Margery G. Smelkinson; Joseph R. Francica; Richard Laga; Joshua D. Bernstock; Leonard W. Seymour; Charles G. Drake; Christopher M. Jewell; Olivier Lantz; Eliane Piaggio; Andrew S. Ishizuka; Robert A. Seder
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Titrating gene expression using libraries of systematically attenuated CRISPR guide RNAs Nat. Biotechnol. (IF 31.864) Pub Date : 2020-01-13 Marco Jost; Daniel A. Santos; Reuben A. Saunders; Max A. Horlbeck; John S. Hawkins; Sonia M. Scaria; Thomas M. Norman; Jeffrey A. Hussmann; Christina R. Liem; Carol A. Gross; Jonathan S. Weissman
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An integrated perfusion machine preserves injured human livers for 1 week Nat. Biotechnol. (IF 31.864) Pub Date : 2020-01-13 Dilmurodjon Eshmuminov; Dustin Becker; Lucia Bautista Borrego; Max Hefti; Martin J. Schuler; Catherine Hagedorn; Xavier Muller; Matteo Mueller; Christopher Onder; Rolf Graf; Achim Weber; Philipp Dutkowski; Philipp Rudolf von Rohr; Pierre-Alain Clavien
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Integrating microarray-based spatial transcriptomics and single-cell RNA-seq reveals tissue architecture in pancreatic ductal adenocarcinomas Nat. Biotechnol. (IF 31.864) Pub Date : 2020-01-13 Reuben Moncada; Dalia Barkley; Florian Wagner; Marta Chiodin; Joseph C. Devlin; Maayan Baron; Cristina H. Hajdu; Diane M. Simeone; Itai Yanai
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Championing leadership development in healthcare Nat. Biotechnol. (IF 31.864) Pub Date : 2020-01-09 Arjun D. Law; Danielle Rodin; Meredith Giuliani; Fabio Y. Moraes
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Antibody engineering Nat. Biotechnol. (IF 31.864) Pub Date : 2020-01-09
Recent patents related to methods of identifying protein modulators and treating influenza A virus.
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When the world needs to know Nat. Biotechnol. (IF 31.864) Pub Date : 2020-01-09
Was the public re-release of data excerpts from an unpublished manuscript on human germline gene editing ethically justified?
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A community effort to create standards for evaluating tumor subclonal reconstruction Nat. Biotechnol. (IF 31.864) Pub Date : 2020-01-09 Adriana Salcedo; Maxime Tarabichi; Shadrielle Melijah G. Espiritu; Amit G. Deshwar; Matei David; Nathan M. Wilson; Stefan Dentro; Jeff A. Wintersinger; Lydia Y. Liu; Minjeong Ko; Srinivasan Sivanandan; Hongjiu Zhang; Kaiyi Zhu; Tai-Hsien Ou Yang; John M. Chilton; Alex Buchanan; Christopher M. Lalansingh; Christine P’ng; Catalina V. Anghel; Imaad Umar; Bryan Lo; William Zou; Jared T. Simpson; Joshua M. Stuart; Dimitris Anastassiou; Yuanfang Guan; Adam D. Ewing; Kyle Ellrott; David C. Wedge; Quaid Morris; Peter Van Loo; Paul C. Boutros
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Analysis of the standard for accepting supplementary experimental data in China’s patent practice Nat. Biotechnol. (IF 31.864) Pub Date : 2020-01-09 Wei Li
Balancing the interests of the applicants and the public, China has imposed strict restrictions on the examination of supplementary experimental data.
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The therapeutic landscape for cells engineered with chimeric antigen receptors Nat. Biotechnol. (IF 31.864) Pub Date : 2020-01-06 Matthew MacKay; Ebrahim Afshinnekoo; Jonathan Rub; Ciaran Hassan; Mihir Khunte; Nithyashri Baskaran; Bryan Owens; Lauren Liu; Gail J. Roboz; Monica L. Guzman; Ari M. Melnick; Shixiu Wu; Christopher E. Mason
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Accurate detection of mosaic variants in sequencing data without matched controls Nat. Biotechnol. (IF 31.864) Pub Date : 2020-01-06 Yanmei Dou; Minseok Kwon; Rachel E. Rodin; Isidro Cortés-Ciriano; Ryan Doan; Lovelace J. Luquette; Alon Galor; Craig Bohrson; Christopher A. Walsh; Peter J. Park
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Author Correction: Visualizing structure and transitions in high-dimensional biological data Nat. Biotechnol. (IF 31.864) Pub Date : 2020-01-02 Kevin R. Moon; David van Dijk; Zheng Wang; Scott Gigante; Daniel B. Burkhardt; William S. Chen; Kristina Yim; Antonia van den Elzen; Matthew J. Hirn; Ronald R. Coifman; Natalia B. Ivanova; Guy Wolf; Smita Krishnaswamy
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Mass spectrometry searches using MASST Nat. Biotechnol. (IF 31.864) Pub Date : 2020-01-01 Mingxun Wang; Alan K. Jarmusch; Fernando Vargas; Alexander A. Aksenov; Julia M. Gauglitz; Kelly Weldon; Daniel Petras; Ricardo da Silva; Robert Quinn; Alexey V. Melnik; Justin J. J. van der Hooft; Andrés Mauricio Caraballo-Rodríguez; Louis Felix Nothias; Christine M. Aceves; Morgan Panitchpakdi; Elizabeth Brown; Francesca Di Ottavio; Nicole Sikora; Emmanuel O. Elijah; Lara Labarta-Bajo; Emily C. Gentry; Shabnam Shalapour; Kathleen E. Kyle; Sara P. Puckett; Jeramie D. Watrous; Carolina S. Carpenter; Amina Bouslimani; Madeleine Ernst; Austin D. Swafford; Elina I. Zúñiga; Marcy J. Balunas; Jonathan L. Klassen; Rohit Loomba; Rob Knight; Nuno Bandeira; Pieter C. Dorrestein
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Integrating scientific considerations into R&D project valuation Nat. Biotechnol. (IF 31.864) Pub Date : 2019-12-27 Saco J. de Visser; Adam F. Cohen; Marcel J. H. Kenter
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Rapid customization of Solanaceae fruit crops for urban agriculture Nat. Biotechnol. (IF 31.864) Pub Date : 2019-12-23 Choon-Tak Kwon; Jung Heo; Zachary H. Lemmon; Yossi Capua; Samuel F. Hutton; Joyce Van Eck; Soon Ju Park; Zachary B. Lippman
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Single-cell analysis of structural variations and complex rearrangements with tri-channel processing Nat. Biotechnol. (IF 31.864) Pub Date : 2019-12-23 Ashley D. Sanders; Sascha Meiers; Maryam Ghareghani; David Porubsky; Hyobin Jeong; M. Alexandra C. C. van Vliet; Tobias Rausch; Paulina Richter-Pechańska; Joachim B. Kunz; Silvia Jenni; Davide Bolognini; Gabriel M. C. Longo; Benjamin Raeder; Venla Kinanen; Jürgen Zimmermann; Vladimir Benes; Martin Schrappe; Balca R. Mardin; Andreas E. Kulozik; Beat Bornhauser; Jean-Pierre Bourquin; Tobias Marschall; Jan O. Korbel
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A reversible RNA on-switch that controls gene expression of AAV-delivered therapeutics in vivo Nat. Biotechnol. (IF 31.864) Pub Date : 2019-12-23 Guocai Zhong; Haimin Wang; Wenhui He; Yujun Li; Huihui Mou; Zachary J. Tickner; Mai H. Tran; Tianling Ou; Yiming Yin; Huitian Diao; Michael Farzan
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Label-free metabolic imaging by mid-infrared optoacoustic microscopy in living cells Nat. Biotechnol. (IF 31.864) Pub Date : 2019-12-23 Miguel A. Pleitez; Asrar Ali Khan; Alice Soldà; Andriy Chmyrov; Josefine Reber; Francesca Gasparin; Markus R. Seeger; Benedikt Schätz; Stephan Herzig; Marcel Scheideler; Vasilis Ntziachristos
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Highly multiplexed single-cell RNA-seq by DNA oligonucleotide tagging of cellular proteins Nat. Biotechnol. (IF 31.864) Pub Date : 2019-12-23 Jase Gehring; Jong Hwee Park; Sisi Chen; Matthew Thomson; Lior Pachter
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Assessing progress in biotech’s gender balance Nat. Biotechnol. (IF 31.864) Pub Date : 2019-12-19 John Hodgson
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Publisher Correction: Harnessing the intracellular triacylglycerols for titer improvement of polyketides in Streptomyces Nat. Biotechnol. (IF 31.864) Pub Date : 2019-12-18 Weishan Wang; Shanshan Li; Zilong Li; Jingyu Zhang; Keqiang Fan; Gaoyi Tan; Guomin Ai; Sin Man Lam; Guanghou Shui; Zhiheng Yang; Hongzhong Lu; Pinjiao Jin; Yihong Li; Xiangyin Chen; Xuekui Xia; Xueting Liu; H. Kathleen Dannelly; Chen Yang; Yi Yang; Siliang Zhang; Gil Alterovitz; Wensheng Xiang; Lixin Zhang
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Electrical recognition of the twenty proteinogenic amino acids using an aerolysin nanopore Nat. Biotechnol. (IF 31.864) Pub Date : 2019-12-16 Hadjer Ouldali; Kumar Sarthak; Tobias Ensslen; Fabien Piguet; Philippe Manivet; Juan Pelta; Jan C. Behrends; Aleksei Aksimentiev; Abdelghani Oukhaled
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Fast-track for engineered plants Nat. Biotechnol. (IF 31.864) Pub Date : 2019-12-16 Oliver Xiaoou Dong; Pamela C. Ronald
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Efficient, continuous mutagenesis in human cells using a pseudo-random DNA editor Nat. Biotechnol. (IF 31.864) Pub Date : 2019-12-16 Haiqi Chen; Sophia Liu; Samuel Padula; Daniel Lesman; Kettner Griswold; Allen Lin; Tongtong Zhao; Jamie L. Marshall; Fei Chen
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A large peptidome dataset improves HLA class I epitope prediction across most of the human population Nat. Biotechnol. (IF 31.864) Pub Date : 2019-12-16 Siranush Sarkizova; Susan Klaeger; Phuong M. Le; Letitia W. Li; Giacomo Oliveira; Hasmik Keshishian; Christina R. Hartigan; Wandi Zhang; David A. Braun; Keith L. Ligon; Pavan Bachireddy; Ioannis K. Zervantonakis; Jennifer M. Rosenbluth; Tamara Ouspenskaia; Travis Law; Sune Justesen; Jonathan Stevens; William J. Lane; Thomas Eisenhaure; Guang Lan Zhang; Karl R. Clauser; Nir Hacohen; Steven A. Carr; Catherine J. Wu; Derin B. Keskin
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Plant gene editing through de novo induction of meristems Nat. Biotechnol. (IF 31.864) Pub Date : 2019-12-16 Michael F. Maher; Ryan A. Nasti; Macy Vollbrecht; Colby G. Starker; Matthew D. Clark; Daniel F. Voytas
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The industrial yeast Pichia pastoris is converted from a heterotroph into an autotroph capable of growth on CO 2 Nat. Biotechnol. (IF 31.864) Pub Date : 2019-12-16 Thomas Gassler; Michael Sauer; Brigitte Gasser; Michael Egermeier; Christina Troyer; Tim Causon; Stephan Hann; Diethard Mattanovich; Matthias G. Steiger
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A DNA-of-things storage architecture to create materials with embedded memory Nat. Biotechnol. (IF 31.864) Pub Date : 2019-12-09 Julian Koch, Silvan Gantenbein, Kunal Masania, Wendelin J. Stark, Yaniv Erlich, Robert N. Grass
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Harnessing the intracellular triacylglycerols for titer improvement of polyketides in Streptomyces Nat. Biotechnol. (IF 31.864) Pub Date : 2019-12-09 Weishan Wang, Shanshan Li, Zilong Li, Jingyu Zhang, Keqiang Fan, Gaoyi Tan, Guomin Ai, Sin Man Lam, Guanghou Shui, Zhiheng Yang, Hongzhong Lu, Pinjiao Jin, Yihong Li, Xiangyin Chen, Xuekui Xia, Xueting Liu, H. Kathleen Dannelly, Chen Yang, Yi Yang, Siliang Zhang, Gil Alterovitz, Wensheng Xiang, Lixin Zhang
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Polymer-stabilized Cas9 nanoparticles and modified repair templates increase genome editing efficiency Nat. Biotechnol. (IF 31.864) Pub Date : 2019-12-09 David N. Nguyen, Theodore L. Roth, P. Jonathan Li, Peixin Amy Chen, Ryan Apathy, Murad R. Mamedov, Linda T. Vo, Victoria R. Tobin, Daniel Goodman, Eric Shifrut, Jeffrey A. Bluestone, Jennifer M. Puck, Francis C. Szoka, Alexander Marson
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The functional landscape of the human phosphoproteome Nat. Biotechnol. (IF 31.864) Pub Date : 2019-12-09 David Ochoa, Andrew F. Jarnuczak, Cristina Viéitez, Maja Gehre, Margaret Soucheray, André Mateus, Askar A. Kleefeldt, Anthony Hill, Luz Garcia-Alonso, Frank Stein, Nevan J. Krogan, Mikhail M. Savitski, Danielle L. Swaney, Juan A. Vizcaíno, Kyung-Min Noh, Pedro Beltrao
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PCSK9 -gene-silencing, cholesterol-lowering drug impresses Nat. Biotechnol. (IF 31.864) Pub Date : 2019-12-03 Cormac Sheridan
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Patients with porphyria bask in sunlight of FDA approval Nat. Biotechnol. (IF 31.864) Pub Date : 2019-12-03 Mark Ratner
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Top 20 translational researchers of 2018 Nat. Biotechnol. (IF 31.864) Pub Date : 2019-12-03 Brady Huggett, Kathryn Paisner
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Exploring a world of a thousand dimensions Nat. Biotechnol. (IF 31.864) Pub Date : 2019-12-03 Catalina A. Vallejos
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Embedding academic and professional skills training with experimental-design chalk talks Nat. Biotechnol. (IF 31.864) Pub Date : 2019-12-03 Ronald J. Heustis, Madhvi J. Venkatesh, Johanna L. Gutlerner, Joseph J. Loparo
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Visualizing structure and transitions in high-dimensional biological data Nat. Biotechnol. (IF 31.864) Pub Date : 2019-12-03 Kevin R. Moon, David van Dijk, Zheng Wang, Scott Gigante, Daniel B. Burkhardt, William S. Chen, Kristina Yim, Antonia van den Elzen, Matthew J. Hirn, Ronald R. Coifman, Natalia B. Ivanova, Guy Wolf, Smita Krishnaswamy
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Access and openness in biotechnology research collaborations between universities and industry Nat. Biotechnol. (IF 31.864) Pub Date : 2019-12-03 Knut Jørgen Egelie, Haakon Thue Lie, Christoph Grimpe, Roger Sørheim
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Optogenetics Nat. Biotechnol. (IF 31.864) Pub Date : 2019-12-03
Recent patents related to the use of optogenetics for neural stimulation, interface for prosthetic devices and control of the secretion of polypeptides of interest.
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Nature and biotechnology Nat. Biotechnol. (IF 31.864) Pub Date : 2019-12-03
150 years after its founding, Nature has not only published some of biotech’s seminal papers, but also profoundly influenced the sector’s impact on society.
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The accelerating pace of biotech democratization Nat. Biotechnol. (IF 31.864) Pub Date : 2019-12-03 Shawn S. Jackson, Louise E. Sumner, Christian H. Garnier, Casey Basham, Landy T. Sun, Peter L. Simone, Danielle S. Gardner, Rocco J. Casagrande
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Cut-price CAR-T cell therapies top India’s biotech agenda Nat. Biotechnol. (IF 31.864) Pub Date : 2019-12-03 Killugudi Jayaraman
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Single-cell multiomic analysis identifies regulatory programs in mixed-phenotype acute leukemia Nat. Biotechnol. (IF 31.864) Pub Date : 2019-12-02 Jeffrey M. Granja, Sandy Klemm, Lisa M. McGinnis, Arwa S. Kathiria, Anja Mezger, M. Ryan Corces, Benjamin Parks, Eric Gars, Michaela Liedtke, Grace X. Y. Zheng, Howard Y. Chang, Ravindra Majeti, William J. Greenleaf
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Phage combination therapies for bacterial wilt disease in tomato Nat. Biotechnol. (IF 31.864) Pub Date : 2019-12-02 Xiaofang Wang, Zhong Wei, Keming Yang, Jianing Wang, Alexandre Jousset, Yangchun Xu, Qirong Shen, Ville-Petri Friman
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Large multiple sequence alignments with a root-to-leaf regressive method Nat. Biotechnol. (IF 31.864) Pub Date : 2019-12-02 Edgar Garriga, Paolo Di Tommaso, Cedrik Magis, Ionas Erb, Leila Mansouri, Athanasios Baltzis, Hafid Laayouni, Fyodor Kondrashov, Evan Floden, Cedric Notredame
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From single-cell RNA-seq to transcriptional regulation Nat. Biotechnol. (IF 31.864) Pub Date : 2019-12-02 Gioele La Manno
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Deciphering eukaryotic gene-regulatory logic with 100 million random promoters Nat. Biotechnol. (IF 31.864) Pub Date : 2019-12-02 Carl G. de Boer, Eeshit Dhaval Vaishnav, Ronen Sadeh, Esteban Luis Abeyta, Nir Friedman, Aviv Regev
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Probing and engineering liquid-phase organelles Nat. Biotechnol. (IF 31.864) Pub Date : 2019-12-02 Dan Bracha, Mackenzie T. Walls, Clifford P. Brangwynne
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