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From air to your plate: tech startups making food from atmospheric CO2 Nat. Biotechnol. (IF 46.9) Pub Date : 2023-09-26
Food tech companies are taking bacteria that capture CO2 from air to make edible and nutritious food and drink.
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Vector BioPharma: resurrecting adenoviral gene delivery Nat. Biotechnol. (IF 46.9) Pub Date : 2023-09-26
Two veteran protein engineers team up to create a new gene-delivery vehicle.
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Single-cell lineage capture across genomic modalities with CellTag-multi reveals fate-specific gene regulatory changes Nat. Biotechnol. (IF 46.9) Pub Date : 2023-09-25 Kunal Jindal, Mohd Tayyab Adil, Naoto Yamaguchi, Xue Yang, Helen C. Wang, Kenji Kamimoto, Guillermo C. Rivera-Gonzalez, Samantha A. Morris
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Dissecting key regulators of transcriptome kinetics through scalable single-cell RNA profiling of pooled CRISPR screens Nat. Biotechnol. (IF 46.9) Pub Date : 2023-09-25 Zihan Xu, Andras Sziraki, Jasper Lee, Wei Zhou, Junyue Cao
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Fast and accurate identification of plasmids and viruses in sequencing data using geNomad Nat. Biotechnol. (IF 46.9) Pub Date : 2023-09-21
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Supervised discovery of interpretable gene programs from single-cell data Nat. Biotechnol. (IF 46.9) Pub Date : 2023-09-21 Russell Z. Kunes, Thomas Walle, Max Land, Tal Nawy, Dana Pe’er
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A DNA nanodevice for mapping sodium at single-organelle resolution Nat. Biotechnol. (IF 46.9) Pub Date : 2023-09-21 Junyi Zou, Koushambi Mitra, Palapuravan Anees, Daphne Oettinger, Joseph R. Ramirez, Aneesh Tazhe Veetil, Priyanka Dutta Gupta, Rajini Rao, Jayson J. Smith, Paschalis Kratsios, Yamuna Krishnan
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Decoding the building blocks of cellular processes from single-cell transcriptomics data Nat. Biotechnol. (IF 46.9) Pub Date : 2023-09-21
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Precision RNA base editing with engineered and endogenous effectors Nat. Biotechnol. (IF 46.9) Pub Date : 2023-09-21 Laura S. Pfeiffer, Thorsten Stafforst
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Identification of mobile genetic elements with geNomad Nat. Biotechnol. (IF 46.9) Pub Date : 2023-09-21 Antonio Pedro Camargo, Simon Roux, Frederik Schulz, Michal Babinski, Yan Xu, Bin Hu, Patrick S. G. Chain, Stephen Nayfach, Nikos C. Kyrpides
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Detection of transcriptome-wide microRNA–target interactions in single cells with agoTRIBE Nat. Biotechnol. (IF 46.9) Pub Date : 2023-09-21 Vaishnovi Sekar, Emilio Mármol-Sánchez, Panagiotis Kalogeropoulos, Laura Stanicek, Eduardo A. Sagredo, Albin Widmark, Evangelos Doukoumopoulos, Franziska Bonath, Inna Biryukova, Marc R. Friedländer
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Detecting organelle-specific activity of potassium channels with a DNA nanodevice Nat. Biotechnol. (IF 46.9) Pub Date : 2023-09-21 Palapuravan Anees, Anand Saminathan, Ezekiel R. Rozmus, Anke Di, Asrar B. Malik, Brian P. Delisle, Yamuna Krishnan
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Peptone: finding opportunity in disorder Nat. Biotechnol. (IF 46.9) Pub Date : 2023-09-19
Combining experimental and computational tools, this company is targeting disordered regions of proteins previously thought to be undruggable.
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Electroosmotic flow across nanopores for single-molecule protein sequencing Nat. Biotechnol. (IF 46.9) Pub Date : 2023-09-18
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Translocation of linearized full-length proteins through an engineered nanopore under opposing electrophoretic force Nat. Biotechnol. (IF 46.9) Pub Date : 2023-09-18 Adina Sauciuc, Blasco Morozzo della Rocca, Matthijs Jonathan Tadema, Mauro Chinappi, Giovanni Maglia
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Scalable genomic data exchange and analytics with sBeacon Nat. Biotechnol. (IF 46.9) Pub Date : 2023-09-14 Anuradha Wickramarachchi, Brendan Hosking, Yatish Jain, John Grimes, Mitchell J. O’Brien, Tracey Wright, Mark A. Burgess, Victor San Kho Lin, Florian Reisinger, Oliver Hofmann, Michael Lawley, Laurence O. W. Wilson, Natalie A. Twine, Denis C. Bauer
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A new chance for genome editing in Europe Nat. Biotechnol. (IF 46.9) Pub Date : 2023-09-14 Hervé Vanderschuren, Patience Chatukuta, Detlef Weigel, Devang Mehta
European universities and research institutions helped to pioneer the development of key technologies for the genetic engineering of crops1. Despite its early leading role, Europe has largely resisted the use of modern genetic technologies in agriculture. The combined implementation of an unofficial moratorium on the cultivation and import of transgenic genetically modified organisms (GMOs) (1998–2004)
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Self-organizing models of human trunk organogenesis recapitulate spinal cord and spine co-morphogenesis Nat. Biotechnol. (IF 46.9) Pub Date : 2023-09-14 Simona Gribaudo, Rémi Robert, Björn van Sambeek, Camil Mirdass, Anna Lyubimova, Kamal Bouhali, Julien Ferent, Xavier Morin, Alexander van Oudenaarden, Stéphane Nedelec
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Septerna: making another run on GPCRs Nat. Biotechnol. (IF 46.9) Pub Date : 2023-09-14
Some 700 approved therapies in the United States — roughly a third of all drugs on the market — target G-protein-coupled receptors (GPCRs). Now advances in high-throughput and structure-based screening are sparking a second golden age of GPCR-based drug discovery.
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Targeted genome editing with a DNA-dependent DNA polymerase and exogenous DNA-containing templates Nat. Biotechnol. (IF 46.9) Pub Date : 2023-09-14 Bin Liu, Xiaolong Dong, Chunwei Zheng, David Keener, Zexiang Chen, Haoyang Cheng, Jonathan K. Watts, Wen Xue, Erik J. Sontheimer
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Parkinson’s iPSC trial Nat. Biotechnol. (IF 46.9) Pub Date : 2023-09-12
The US Food and Drug Administration has given a green light to a clinical trial designed to test patient-derived induced pluripotent stem cells (iPSCs) in patients with Parkinson’s disease.
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When are your cells no longer your own? Nat. Biotechnol. (IF 46.9) Pub Date : 2023-09-12
Cell lines from human samples have historically benefitted scientific research but continue to raise questions about consent.
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Five questions with Mor Nitzan Nat. Biotechnol. (IF 46.9) Pub Date : 2023-09-12 Julie Chuong
An expert in network dynamics and cell interactions describes her interdisciplinary background, creativity and building community in her lab during a pandemic.
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BugSigDB captures patterns of differential abundance across a broad range of host-associated microbial signatures Nat. Biotechnol. (IF 46.9) Pub Date : 2023-09-11 Ludwig Geistlinger, Chloe Mirzayi, Fatima Zohra, Rimsha Azhar, Shaimaa Elsafoury, Clare Grieve, Jennifer Wokaty, Samuel David Gamboa-Tuz, Pratyay Sengupta, Issac Hecht, Aarthi Ravikrishnan, Rafael S. Gonçalves, Eric Franzosa, Karthik Raman, Vincent Carey, Jennifer B. Dowd, Heidi E. Jones, Sean Davis, Nicola Segata, Curtis Huttenhower, Levi Waldron
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Targeting hematopoietic stem cells in vivo Nat. Biotechnol. (IF 46.9) Pub Date : 2023-09-12 Kathryn Aschheim
Gene-therapy research is making steady progress on an array of blood-cell diseases, including immunodeficiencies, sickle cell disease and thalassemia. These programs may use gene transfer or gene editing, but all of them require engineering of patients’ hematopoietic stem cells (HSCs) in the laboratory. In an arduous procedure modeled on stem cell transplants for cancer, HSCs are mobilized from the
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FDA approves first-in-class bispecific for multiple myeloma Nat. Biotechnol. (IF 46.9) Pub Date : 2023-09-12
The first GPCR5D-targeted bispecific antibody has won accelerated approval from the US Food and Drug Administration (FDA) as a fifth-line treatment for multiple myeloma (MM) and is poised to get conditional approval from the European Medicines Agency for treating patients who have received at least three previous therapies. Almost all patients with myeloma who receive standard of care relapse.
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Microbiomics Nat. Biotechnol. (IF 46.9) Pub Date : 2023-09-12
Recent patents relating to microbiome classification, modulation and treatment of diseases.
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A biosensor detects tumor DNA in vivo Nat. Biotechnol. (IF 46.9) Pub Date : 2023-09-12 Anne Doerr
Tumor cells have been observed releasing their DNA into surrounding environments, and this cell-free DNA can be purified from blood and detected by existing assays. Writing in Science, Cooper et al. follow an orthogonal approach that avoids some limitations of blood purification of cell-free DNA. They modify a gut microbe that is naturally competent to take up DNA from its environment to discriminate
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Henrietta Lacks lawsuits continue Nat. Biotechnol. (IF 46.9) Pub Date : 2023-09-12
The family of Henrietta Lacks, the woman from whom HeLa cells were sourced in 1951, has sued rare-disease biotech Ultragenyx for unethically profiting from the cell line. The legal action began just days after the family settled a similar lawsuit with Thermo Fisher Scientific. And more legal claims against other companies that profit from the almost ubiquitous HeLa cell line are likely, according to
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Mining extinct proteomes for antimicrobial peptides Nat. Biotechnol. (IF 46.9) Pub Date : 2023-09-12 Barbara Cheifet
Perhaps extinct molecules that once conferred benefits on ancient organisms could today be resurrected for clinical use. A study in Cell Host & Microbe by Maasch et al. applies this idea of “molecular de-extinction,” or the recovery of extinct molecules of life such as nucleic acids or proteins, to drug discovery. Specifically, the authors aim to mine the ancient human paleoproteome to discover now-extinct
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Drugs catch a ride through the blood–brain barrier Nat. Biotechnol. (IF 46.9) Pub Date : 2023-09-12
A new era of brain-penetrant therapies is opening up, as companies hook up drugs to transferrin receptors or use viral capsids to hitch a ride into previously inaccessible regions.
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Hair loss treatments take aim at the immune system Nat. Biotechnol. (IF 46.9) Pub Date : 2023-09-12
Drugs commonly used in rheumatology, the JAK inhibitors, are opening up treatment options for people with autoimmune-driven hair loss, and new mechanistic knowledge is also helping scientists tackle androgenic alopecia, the commonest cause of baldness.
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People Nat. Biotechnol. (IF 46.9) Pub Date : 2023-09-12
Recent moves of note in and around the biotech and pharma industries.
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The global patent landscape of mRNA for diagnosis and therapy Nat. Biotechnol. (IF 46.9) Pub Date : 2023-09-12 Mengru Lyu, Jiyuan Chen, Yeheng Peng, Fang Han, Luyao Gong, Jingfei Guo, Lijuan Tian, Yuan Gao
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Bridging the gap in African biodiversity genomics and bioinformatics Nat. Biotechnol. (IF 46.9) Pub Date : 2023-09-12 Abdoallah Sharaf, Charlotte C. Ndiribe, Taiwo Crossby Omotoriogun, Linelle Abueg, Bouabid Badaoui, Fatu J. Badiane Markey, Girish Beedessee, Diaga Diouf, Vincent C. Duru, Chukwuike Ebuzome, Samuel C. Eziuzor, Yasmina Jaufeerally Fakim, Giulio Formenti, Nidhal Ghanmi, Fatma Zahra Guerfali, Isidore Houaga, Justin Eze Ideozu, Sally Mueni Katee, Slimane Khayi, Josiah O. Kuja, Emmanuel Hala Kwon-Ndung,
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BugSigDB — a database for identifying unusual abundance patterns in human microbiome studies Nat. Biotechnol. (IF 46.9) Pub Date : 2023-09-11
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Direct measurement of engineered cancer mutations and their transcriptional phenotypes in single cells Nat. Biotechnol. (IF 46.9) Pub Date : 2023-09-11 Heon Seok Kim, Susan M. Grimes, Tianqi Chen, Anuja Sathe, Billy T. Lau, Gue-Ho Hwang, Sangsu Bae, Hanlee P. Ji
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Genotoxicity concerns for base and prime editors in hematopoietic stem cells Nat. Biotechnol. (IF 46.9) Pub Date : 2023-09-07
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Congruence Therapeutics: finding a fix for misfolded proteins Nat. Biotechnol. (IF 46.9) Pub Date : 2023-09-07
Stabilizing the unstable may be the road to therapeutics for unmet needs.
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MaxFuse enables data integration across weakly linked spatial and single-cell modalities Nat. Biotechnol. (IF 46.9) Pub Date : 2023-09-07
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Quartet RNA reference materials improve the quality of transcriptomic data through ratio-based profiling Nat. Biotechnol. (IF 46.9) Pub Date : 2023-09-07 Ying Yu, Wanwan Hou, Yaqing Liu, Haiyan Wang, Lianhua Dong, Yuanbang Mai, Qingwang Chen, Zhihui Li, Shanyue Sun, Jingcheng Yang, Zehui Cao, Peipei Zhang, Yi Zi, Ruimei Liu, Jian Gao, Naixin Zhang, Jingjing Li, Luyao Ren, He Jiang, Jun Shang, Sibo Zhu, Xiaolin Wang, Tao Qing, Ding Bao, Bingying Li, Bin Li, Chen Suo, Yan Pi, Xia Wang, Fangping Dai, Andreas Scherer, Pirkko Mattila, Jinxiong Han, Lijun
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Genotoxic effects of base and prime editing in human hematopoietic stem cells Nat. Biotechnol. (IF 46.9) Pub Date : 2023-09-07 Martina Fiumara, Samuele Ferrari, Attya Omer-Javed, Stefano Beretta, Luisa Albano, Daniele Canarutto, Angelica Varesi, Chiara Gaddoni, Chiara Brombin, Federica Cugnata, Erika Zonari, Matteo Maria Naldini, Matteo Barcella, Bernhard Gentner, Ivan Merelli, Luigi Naldini
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Multi-omics data integration using ratio-based quantitative profiling with Quartet reference materials Nat. Biotechnol. (IF 46.9) Pub Date : 2023-09-07 Yuanting Zheng, Yaqing Liu, Jingcheng Yang, Lianhua Dong, Rui Zhang, Sha Tian, Ying Yu, Luyao Ren, Wanwan Hou, Feng Zhu, Yuanbang Mai, Jinxiong Han, Lijun Zhang, Hui Jiang, Ling Lin, Jingwei Lou, Ruiqiang Li, Jingchao Lin, Huafen Liu, Ziqing Kong, Depeng Wang, Fangping Dai, Ding Bao, Zehui Cao, Qiaochu Chen, Qingwang Chen, Xingdong Chen, Yuechen Gao, He Jiang, Bin Li, Bingying Li, Jingjing Li, Ruimei
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Protein remote homology detection and structural alignment using deep learning Nat. Biotechnol. (IF 46.9) Pub Date : 2023-09-07 Tymor Hamamsy, James T. Morton, Robert Blackwell, Daniel Berenberg, Nicholas Carriero, Vladimir Gligorijevic, Charlie E. M. Strauss, Julia Koehler Leman, Kyunghyun Cho, Richard Bonneau
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Integration of spatial and single-cell data across modalities with weakly linked features Nat. Biotechnol. (IF 46.9) Pub Date : 2023-09-07 Shuxiao Chen, Bokai Zhu, Sijia Huang, John W. Hickey, Kevin Z. Lin, Michael Snyder, William J. Greenleaf, Garry P. Nolan, Nancy R. Zhang, Zongming Ma
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Spatial multimodal analysis of transcriptomes and metabolomes in tissues Nat. Biotechnol. (IF 46.9) Pub Date : 2023-09-04 Marco Vicari, Reza Mirzazadeh, Anna Nilsson, Reza Shariatgorji, Patrik Bjärterot, Ludvig Larsson, Hower Lee, Mats Nilsson, Julia Foyer, Markus Ekvall, Paulo Czarnewski, Xiaoqun Zhang, Per Svenningsson, Lukas Käll, Per E. Andrén, Joakim Lundeberg
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Author Correction: Massively parallel single-cell mitochondrial DNA genotyping and chromatin profiling Nat. Biotechnol. (IF 46.9) Pub Date : 2023-08-31 Caleb A. Lareau, Leif S. Ludwig, Christoph Muus, Satyen H. Gohil, Tongtong Zhao, Zachary Chiang, Karin Pelka, Jeffrey M. Verboon, Wendy Luo, Elena Christian, Daniel Rosebrock, Gad Getz, Genevieve M. Boland, Fei Chen, Jason D. Buenrostro, Nir Hacohen, Catherine J. Wu, Martin J. Aryee, Aviv Regev, Vijay G. Sankaran
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Imaging brain tissue architecture across millimeter to nanometer scales Nat. Biotechnol. (IF 46.9) Pub Date : 2023-08-31 Julia M. Michalska, Julia Lyudchik, Philipp Velicky, Hana Štefaničková, Jake F. Watson, Alban Cenameri, Christoph Sommer, Nicole Amberg, Alessandro Venturino, Karl Roessler, Thomas Czech, Romana Höftberger, Sandra Siegert, Gaia Novarino, Peter Jonas, Johann G. Danzl
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Survival of the fittest glia Nat. Biotechnol. (IF 46.9) Pub Date : 2023-08-28 V. Alexandra Moser, Clive N. Svendsen
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Strand-preferred base editing of organellar and nuclear genomes using CyDENT Nat. Biotechnol. (IF 46.9) Pub Date : 2023-08-28 Jiacheng Hu, Yu Sun, Boshu Li, Zhen Liu, Zhiwei Wang, Qiang Gao, Mengyue Guo, Guanwen Liu, Kevin Tianmeng Zhao, Caixia Gao
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Joint single-cell profiling resolves 5mC and 5hmC and reveals their distinct gene regulatory effects Nat. Biotechnol. (IF 46.9) Pub Date : 2023-08-28 Emily B. Fabyanic, Peng Hu, Qi Qiu, Kiara N. Berríos, Daniel R. Connolly, Tong Wang, Jennifer Flournoy, Zhaolan Zhou, Rahul M. Kohli, Hao Wu
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The digital and analog worlds of protein engineering Nat. Biotechnol. (IF 46.9) Pub Date : 2023-08-25 Lada Nuzhna, Tess van Stekelenburg
Over the past decades of protein design research, computational algorithms for studying proteins were often explored for novelty rather than their utility in designing functional proteins — yielding heaps of unvalidated and untranslated research. Marked by the success of AlphaFold, trained on structural databases, only recently have the predictive power of these models become robust enough to start
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Tenure time loopers Nat. Biotechnol. (IF 46.9) Pub Date : 2023-08-25 Nozomu Yachie, Nika Shakiba
Say, “I’m tenured,” and most people think you have a lifelong job guarantee. It is a rare luxury; you would be hard-pressed to find the security that tenure promises beyond academic walls. However, as a mid-career (N.Y.) and junior professor (N.S.) in biotechnology, we challenge academic institutions to rethink the existing tenure model. In short, we are ready to leave the perceived safety of tenure
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The long game of tenure Nat. Biotechnol. (IF 46.9) Pub Date : 2023-08-25 Todd J. Treangen, Moshe Y. Vardi
In 2009, the American Association of University Professors underscored the importance of academic freedom in the light of Garcetti v. Ceballos1 and stated that “The principal purpose of tenure is to safeguard academic freedom, which is necessary for all who teach and conduct research in higher education.” Nevertheless, the institution of tenure is coming under fire in many states across the United
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Scientists hone tools to measure aging and rejuvenation interventions Nat. Biotechnol. (IF 46.9) Pub Date : 2023-08-22
Aging is malleable, at least in animal models. But to prove the efficacy of interventions aimed at extending healthspan and to test life-extending approaches in humans, longevity researchers first need to agree on the best measuring tools. With the power of ’omics, AI and large biobanks, improved biomarkers may be forthcoming. Companies and academic researchers are rallying forces, but how far have
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Machine learning predicts cellular response to genetic perturbation Nat. Biotechnol. (IF 46.9) Pub Date : 2023-08-17
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Predicting transcriptional outcomes of novel multigene perturbations with GEARS Nat. Biotechnol. (IF 46.9) Pub Date : 2023-08-17 Yusuf Roohani, Kexin Huang, Jure Leskovec
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Single-nucleotide variant calling in single-cell sequencing data with Monopogen Nat. Biotechnol. (IF 46.9) Pub Date : 2023-08-17 Jinzhuang Dou, Yukun Tan, Kian Hong Kock, Jun Wang, Xuesen Cheng, Le Min Tan, Kyung Yeon Han, Chung-Chau Hon, Woong-Yang Park, Jay W. Shin, Haijing Jin, Yujia Wang, Han Chen, Li Ding, Shyam Prabhakar, Nicholas Navin, Rui Chen, Ken Chen