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Delix Therapeutics : psychedelics without the trip Nat. Biotechnol. (IF 68.164) Pub Date : 2022-08-19
Non-hallucinogenic versions of drugs like LSD, psilocybin and MDMA could unlock their potential in mental illness.
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Author Correction: A highly photostable and bright green fluorescent protein. Nat. Biotechnol. (IF 68.164) Pub Date : 2022-08-17 Masahiko Hirano,Ryoko Ando,Satoshi Shimozono,Mayu Sugiyama,Noriyo Takeda,Hiroshi Kurokawa,Ryusaku Deguchi,Kazuki Endo,Kei Haga,Reiko Takai-Todaka,Shunsuke Inaura,Yuta Matsumura,Hiroshi Hama,Yasushi Okada,Takahiro Fujiwara,Takuya Morimoto,Kazuhiko Katayama,Atsushi Miyawaki
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Author Correction: Engineering circular RNA for enhanced protein production. Nat. Biotechnol. (IF 68.164) Pub Date : 2022-08-17 Robert Chen,Sean K Wang,Julia A Belk,Laura Amaya,Zhijian Li,Angel Cardenas,Brian T Abe,Chun-Kan Chen,Paul A Wender,Howard Y Chang
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Engineered Cas13 variants with minimal collateral RNA targeting Nat. Biotechnol. (IF 68.164) Pub Date : 2022-08-12
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Abalos Therapeutics---arenaviruses take on cancer Nat. Biotechnol. (IF 68.164) Pub Date : 2022-08-12
After >20 years of research at the intersection of virology and immunology, two brothers have launched a venture seeking to turn arenaviruses into an anticancer virotherapy.
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Accessible bioengineered corneal tissue to address a blinding disease globally Nat. Biotechnol. (IF 68.164) Pub Date : 2022-08-11
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High-fidelity Cas13 variants for targeted RNA degradation with minimal collateral effects Nat. Biotechnol. (IF 68.164) Pub Date : 2022-08-11 Huawei Tong, Jia Huang, Qingquan Xiao, Bingbing He, Xue Dong, Yuanhua Liu, Xiali Yang, Dingyi Han, Zikang Wang, Xuchen Wang, Wenqin Ying, Runze Zhang, Yu Wei, Chunlong Xu, Yingsi Zhou, Yanfei Li, Minqing Cai, Qifang Wang, Mingxing Xue, Guoling Li, Kailun Fang, Hainan Zhang, Hui Yang
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Bioengineered corneal tissue for minimally invasive vision restoration in advanced keratoconus in two clinical cohorts Nat. Biotechnol. (IF 68.164) Pub Date : 2022-08-11 Mehrdad Rafat, Mahmoud Jabbarvand, Namrata Sharma, Maria Xeroudaki, Shideh Tabe, Raha Omrani, Muthukumar Thangavelu, Anthony Mukwaya, Per Fagerholm, Anton Lennikov, Farshad Askarizadeh, Neil Lagali
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Epigenomics Nat. Biotechnol. (IF 68.164) Pub Date : 2022-08-09
Recent patents relating to epigenomic analyses, modification and engineering.
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Second-quarter biotech job picture Nat. Biotechnol. (IF 68.164) Pub Date : 2022-08-09 Michael Francisco
A quarterly snapshot of job expansions, reductions and availability in the biotech and pharma sectors.
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Patents benefit patients and patent reform would spur diagnostic and therapeutic development Nat. Biotechnol. (IF 68.164) Pub Date : 2022-08-09 Laura A. Coruzzi
Patients need the patent system to spur the investment necessary for the continued development of life-saving diagnostics and therapies.
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Can hackathons unlock a new talent pool from the developing world? Nat. Biotechnol. (IF 68.164) Pub Date : 2022-08-09 Timothy P. Jenkins, Nicolas Lopez Carranza, Amy Bray, Karim Beguir, Andreas H. Laustsen
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People Nat. Biotechnol. (IF 68.164) Pub Date : 2022-08-09
Recent moves of note in and around the biotech and pharma industries.
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HER3-addicted tumors: how biotechs are closing in Nat. Biotechnol. (IF 68.164) Pub Date : 2022-08-09
The elusive HER3, known to drive aggressive cancers, may finally be toppled by once-abandoned antibody drugs.
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mRNA printers kick-start personalized medicines for all Nat. Biotechnol. (IF 68.164) Pub Date : 2022-08-09
mRNA printers will bring low-cost vaccines and made-to-order treatments for a range of different diseases.
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A DNA Typewriter in living cells. Nat. Biotechnol. (IF 68.164) Pub Date : 2022-08-01 Eleni Kotsiliti
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Drug pipeline 2Q22 - a downturn in approvals. Nat. Biotechnol. (IF 68.164) Pub Date : 2022-08-01 Laura DeFrancesco
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Orna Therapeutics: circular logic Nat. Biotechnol. (IF 68.164) Pub Date : 2022-08-05
In the ascendant world of mRNA medicines, circular RNA shows promise as an alternative way for making proteins inside human cells.
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The digital phenotype of vaccination Nat. Biotechnol. (IF 68.164) Pub Date : 2022-08-03 Giorgio Quer, Eric J. Topol, Steven R. Steinhubl
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Increase vigilance against cyberattacks Nat. Biotechnol. (IF 68.164) Pub Date : 2022-08-03
The biotech sector must devote more resources to cybersecurity — especially those companies that are manufacturers of essential medical products.
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The BioInnovation Institute as a catalyst for European life science startup creation Nat. Biotechnol. (IF 68.164) Pub Date : 2022-08-03 Jens Nielsen, Markus J. Herrgård, Bobby Soni
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BEHAV3D: an imaging and transcriptomics platform that unravels T cell antitumor activity Nat. Biotechnol. (IF 68.164) Pub Date : 2022-07-28
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Precision cancer targeting with antibody pairs Nat. Biotechnol. (IF 68.164) Pub Date : 2022-07-25 Robert T. Lawrence, Peter D. Senter
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Ras-mutant cancers are sensitive to small molecule inhibition of V-type ATPases in mice Nat. Biotechnol. (IF 68.164) Pub Date : 2022-07-25 Bhairavi Tolani, Anna Celli, Yanmin Yao, Yong Zi Tan, Richard Fetter, Christina R. Liem, Adam J. de Smith, Thamiya Vasanthakumar, Paola Bisignano, Adam D. Cotton, Ian B. Seiple, John L. Rubinstein, Marco Jost, Jonathan S. Weissman
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Logic-gated antibody pairs that selectively act on cells co-expressing two antigens Nat. Biotechnol. (IF 68.164) Pub Date : 2022-07-25 Simone C. Oostindie, Derek A. Rinaldi, Gijs G. Zom, Michael J. Wester, Desiree Paulet, Kusai Al-Tamimi, Els van der Meijden, Jennifer R. Scheick, Tessa Wilpshaar, Bart de Jong, Marloes Hoff-van den Broek, Rachel M. Grattan, Janita J. Oosterhoff, Julie Vignau, Sandra Verploegen, Peter Boross, Frank J. Beurskens, Diane S. Lidke, Janine Schuurman, Rob N. de Jong
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Uncovering the mode of action of engineered T cells in patient cancer organoids Nat. Biotechnol. (IF 68.164) Pub Date : 2022-07-25 Johanna F. Dekkers, Maria Alieva, Astrid Cleven, Farid Keramati, Amber K. L. Wezenaar, Esmée J. van Vliet, Jens Puschhof, Peter Brazda, Inez Johanna, Angelo D. Meringa, Heggert G. Rebel, Maj-Britt Buchholz, Mario Barrera Román, Amber L. Zeeman, Sam de Blank, Domenico Fasci, Maarten H. Geurts, Annelisa M. Cornel, Else Driehuis, Rosemary Millen, Trudy Straetemans, Mara J. T. Nicolasen, Tineke Aarts-Riemens
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A new route to vaccines using PROTACs Nat. Biotechnol. (IF 68.164) Pub Date : 2022-07-22 Brad Gilbertson, Kanta Subbarao
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Wastewater is a robust proxy for monitoring circulating SARS-CoV-2 variants Nat. Biotechnol. (IF 68.164) Pub Date : 2022-07-21
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The trispecific DARPin ensovibep inhibits diverse SARS-CoV-2 variants Nat. Biotechnol. (IF 68.164) Pub Date : 2022-07-21 Sylvia Rothenberger, Daniel L. Hurdiss, Marcel Walser, Francesca Malvezzi, Jennifer Mayor, Sarah Ryter, Hector Moreno, Nicole Liechti, Andreas Bosshart, Chloé Iss, Valérie Calabro, Andreas Cornelius, Tanja Hospodarsch, Alexandra Neculcea, Thamar Looser, Anja Schlegel, Simon Fontaine, Denis Villemagne, Maria Paladino, Dieter Schiegg, Susanne Mangold, Christian Reichen, Filip Radom, Yvonne Kaufmann,
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Framework for multiplicative scaling of single-cell proteomics Nat. Biotechnol. (IF 68.164) Pub Date : 2022-07-18
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Engineering circular RNA for enhanced protein production Nat. Biotechnol. (IF 68.164) Pub Date : 2022-07-18 Robert Chen, Sean K. Wang, Julia A. Belk, Laura Amaya, Zhijian Li, Angel Cardenas, Brian T. Abe, Chun-Kan Chen, Paul A. Wender, Howard Y. Chang
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Viral variant-resolved wastewater surveillance of SARS-CoV-2 at national scale Nat. Biotechnol. (IF 68.164) Pub Date : 2022-07-18 Fabian Amman, Rudolf Markt, Lukas Endler, Sebastian Hupfauf, Benedikt Agerer, Anna Schedl, Lukas Richter, Melanie Zechmeister, Martin Bicher, Georg Heiler, Petr Triska, Matthew Thornton, Thomas Penz, Martin Senekowitsch, Jan Laine, Zsofia Keszei, Peter Klimek, Fabiana Nägele, Markus Mayr, Beatrice Daleiden, Martin Steinlechner, Harald Niederstätter, Petra Heidinger, Wolfgang Rauch, Christoph Scheffknecht
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Increasing the throughput of sensitive proteomics by plexDIA Nat. Biotechnol. (IF 68.164) Pub Date : 2022-07-14 Jason Derks, Andrew Leduc, Georg Wallmann, R. Gray Huffman, Matthew Willetts, Saad Khan, Harrison Specht, Markus Ralser, Vadim Demichev, Nikolai Slavov
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People Nat. Biotechnol. (IF 68.164) Pub Date : 2022-07-13
Recent moves of note in and around the biotech and pharma industries.
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RNA drugs lower lipoprotein(a) and genetically driven cholesterol Nat. Biotechnol. (IF 68.164) Pub Date : 2022-07-13
Companies are deploying siRNA and antisense oligonucleotides to tackle dangerously high cholesterol driven by genetics, betting that a wider population will benefit.
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Immuno-oncology checkpoint inhibitors Nat. Biotechnol. (IF 68.164) Pub Date : 2022-07-13
Recent patents relating to checkpoint inhibitors and their use in treating cancers.
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IL-2 upgrades show promise at ASCO Nat. Biotechnol. (IF 68.164) Pub Date : 2022-07-13
Companies pursue souped-up IL-2 candidates, undeterred by Nektar’s setback.
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What digitalization in biology R&D means for biotech companies and life scientists Nat. Biotechnol. (IF 68.164) Pub Date : 2022-07-13 Sybil Wong, Mingke Pan, Allen Shaw, Markus Gershater
The digitalization of R&D can potentially transform the life sciences, but it cannot succeed without experts collaborating to develop a vision of what a better working environment can look like.
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Standardized annotation of translated open reading frames Nat. Biotechnol. (IF 68.164) Pub Date : 2022-07-13 Jonathan M. Mudge, Jorge Ruiz-Orera, John R. Prensner, Marie A. Brunet, Ferriol Calvet, Irwin Jungreis, Jose Manuel Gonzalez, Michele Magrane, Thomas F. Martinez, Jana Felicitas Schulz, Yucheng T. Yang, M. Mar Albà, Julie L. Aspden, Pavel V. Baranov, Ariel A. Bazzini, Elspeth Bruford, Maria Jesus Martin, Lorenzo Calviello, Anne-Ruxandra Carvunis, Jin Chen, Juan Pablo Couso, Eric W. Deutsch, Paul Flicek
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Bluebird's CALD gene therapy poised for approval. Nat. Biotechnol. (IF 68.164) Pub Date : 2022-07-01
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Enhancing untargeted metabolomics using metadata-based source annotation Nat. Biotechnol. (IF 68.164) Pub Date : 2022-07-07 Julia M. Gauglitz, Kiana A. West, Wout Bittremieux, Candace L. Williams, Kelly C. Weldon, Morgan Panitchpakdi, Francesca Di Ottavio, Christine M. Aceves, Elizabeth Brown, Nicole C. Sikora, Alan K. Jarmusch, Cameron Martino, Anupriya Tripathi, Michael J. Meehan, Kathleen Dorrestein, Justin P. Shaffer, Roxana Coras, Fernando Vargas, Lindsay DeRight Goldasich, Tara Schwartz, MacKenzie Bryant, Gregory
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Revisiting checkpoint blockade Nat. Biotechnol. (IF 68.164) Pub Date : 2022-07-05
After over a decade of experience with immune checkpoint inhibitors in oncology, more effort needs to be spent unraveling why some patients respond — and why the majority do not — and integrating knowledge about biomarkers into patient selection in trials.
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Identifying drug combinations that enhance treatment responses mediated by the tumor microenvironment Nat. Biotechnol. (IF 68.164) Pub Date : 2022-07-04
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A multiplex implantable microdevice assay identifies synergistic combinations of cancer immunotherapies and conventional drugs Nat. Biotechnol. (IF 68.164) Pub Date : 2022-07-04 Zuzana Tatarova, Dylan C. Blumberg, James E. Korkola, Laura M. Heiser, John L. Muschler, Pepper J. Schedin, Sebastian W. Ahn, Gordon B. Mills, Lisa M. Coussens, Oliver Jonas, Joe W. Gray
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Generation of a live attenuated influenza A vaccine by proteolysis targeting Nat. Biotechnol. (IF 68.164) Pub Date : 2022-07-04 Longlong Si, Quan Shen, Jing Li, Li Chen, Jinying Shen, Xue Xiao, Haiqing Bai, Tang Feng, Adam Yongxin Ye, Le Li, Chunhe Zhang, Zhen Li, Ping Wang, Crystal Yuri Oh, Atiq Nurani, Siwen Niu, Chengxin Zhang, Xiaoqiong Wei, Wanqiong Yuan, Hao Liao, Xiaojie Huang, Ning Wang, Wen-xia Tian, Hongwei Tian, Li Li, Xiaoheng Liu, Roberto Plebani
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Synthetic memory circuits for stable cell reprogramming in plants Nat. Biotechnol. (IF 68.164) Pub Date : 2022-07-04 James P. B. Lloyd, Florence Ly, Patrick Gong, Jahnvi Pflueger, Tessa Swain, Christian Pflueger, Elliott Fourie, Muhammad Adil Khan, Brendan N. Kidd, Ryan Lister
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Frequent aneuploidy in primary human T cells after CRISPR–Cas9 cleavage Nat. Biotechnol. (IF 68.164) Pub Date : 2022-06-30 Alessio David Nahmad, Eli Reuveni, Ella Goldschmidt, Tamar Tenne, Meytal Liberman, Miriam Horovitz-Fried, Rami Khosravi, Hila Kobo, Eyal Reinstein, Asaf Madi, Uri Ben-David, Adi Barzel
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Profiling the total single-cell transciptome using droplet microfluidics Nat. Biotechnol. (IF 68.164) Pub Date : 2022-06-28
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Archiving the genomic and genetic resources of glaciers Nat. Biotechnol. (IF 68.164) Pub Date : 2022-06-27
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High-throughput total RNA sequencing in single cells using VASA-seq Nat. Biotechnol. (IF 68.164) Pub Date : 2022-06-27 Fredrik Salmen, Joachim De Jonghe, Tomasz S. Kaminski, Anna Alemany, Guillermo E. Parada, Joe Verity-Legg, Ayaka Yanagida, Timo N. Kohler, Nicholas Battich, Floris van den Brekel, Anna L. Ellermann, Alfonso Martinez Arias, Jennifer Nichols, Martin Hemberg, Florian Hollfelder, Alexander van Oudenaarden
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A genome and gene catalog of glacier microbiomes Nat. Biotechnol. (IF 68.164) Pub Date : 2022-06-27 Yongqin Liu, Mukan Ji, Tao Yu, Julian Zaugg, Alexandre M. Anesio, Zhihao Zhang, Songnian Hu, Philip Hugenholtz, Keshao Liu, Pengfei Liu, Yuying Chen, Yingfeng Luo, Tandong Yao
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Plant hormone sensors as scaffolds for biosensor design Nat. Biotechnol. (IF 68.164) Pub Date : 2022-06-20
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Genome-wide mapping of somatic mutation rates uncovers drivers of cancer Nat. Biotechnol. (IF 68.164) Pub Date : 2022-06-20 Maxwell A. Sherman, Adam U. Yaari, Oliver Priebe, Felix Dietlein, Po-Ru Loh, Bonnie Berger