Human T cell generation is restored in CD3δ severe combined immunodeficiency through adenine base editing
Cell
(IF 66.85)
Pub Date : 2023-03-20
Grace E. McAuley, Gloria Yiu, Patrick C. Chang, Gregory A. Newby, Beatriz Campo-Fernandez, Sorel T. Fitz-Gibbon, Xiaomeng Wu, Sung-Hae L. Kang, Amber Garibay, Jeffrey Butler, Valentina Christian, Ryan L. Wong, Kelcee A. Everette, Anthony Azzun, Hila Gelfer, Christopher S. Seet, Aru Narendran, Luis Murguia-Favela, Zulema Romero, Nicola Wright, Donald B. Kohn
Dynamic CD8+ T cell responses to cancer immunotherapy in human regional lymph nodes are disrupted in metastatic lymph nodes
Cell
(IF 66.85)
Pub Date : 2023-03-16
Maha K. Rahim, Trine Line H. Okholm, Kyle B. Jones, Elizabeth E. McCarthy, Candace C. Liu, Jacqueline L. Yee, Stanley J. Tamaki, Diana M. Marquez, Iliana Tenvooren, Katherine Wai, Alexander Cheung, Brittany R. Davidson, Vrinda Johri, Bushra Samad, William E. O’Gorman, Matthew F. Krummel, Annemieke van Zante, Alexis J. Combes, Michael Angelo, Lawrence Fong, Matthew H. Spitzer
HIV-1 remission and possible cure in a woman after haplo-cord blood transplant
Cell
(IF 66.85)
Pub Date : 2023-03-16
Jingmei Hsu, Koen Van Besien, Marshall J. Glesby, Savita Pahwa, Anne Coletti, Meredith G. Warshaw, Larry Petz, Theodore B. Moore, Ya Hui Chen, Suresh Pallikkuth, Adit Dhummakupt, Ruth Cortado, Amanda Golner, Frederic Bone, Maria Baldo, Marcie Riches, John W. Mellors, Nicole H. Tobin, Renee Browning, Deborah Persaud, Dwight Yin
Single substitution in H3.3G34 alters DNMT3A recruitment to cause progressive neurodegeneration
Cell
(IF 66.85)
Pub Date : 2023-03-16
Sima Khazaei, Carol C.L. Chen, Augusto Faria Andrade, Nisha Kabir, Pariya Azarafshar, Shahir M. Morcos, Josiane Alves França, Mariana Lopes, Peder J. Lund, Geoffroy Danieau, Samantha Worme, Lata Adnani, Nadine Nzirorera, Xiao Chen, Gayathri Yogarajah, Caterina Russo, Michele Zeinieh, Cassandra J. Wong, Laura Bryant, Steven Hébert, Nada Jabado
Biophysical forces mediated by respiration maintain lung alveolar epithelial cell fate
Cell
(IF 66.85)
Pub Date : 2023-03-03
Kazushige Shiraishi, Parisha P. Shah, Michael P. Morley, Claudia Loebel, Garrett T. Santini, Jeremy Katzen, Maria C. Basil, Susan M. Lin, Joseph D. Planer, Edward Cantu, Dakota L. Jones, Ana N. Nottingham, Shanru Li, Fabian L. Cardenas-Diaz, Su Zhou, Jason A. Burdick, Rajan Jain, Edward E. Morrisey
Whole-genome sequencing reveals a complex African population demographic history and signatures of local adaptation
Cell
(IF 66.85)
Pub Date : 2023-03-02
Shaohua Fan, Jeffrey P. Spence, Yuanqing Feng, Matthew E.B. Hansen, Jonathan Terhorst, Marcia H. Beltrame, Alessia Ranciaro, Jibril Hirbo, William Beggs, Neil Thomas, Thomas Nyambo, Sununguko Wata Mpoloka, Gaonyadiwe George Mokone, Alfred Njamnshi, Charles Folkunang, Dawit Wolde Meskel, Gurja Belay, Yun S. Song, Sarah A. Tishkoff
Apoptotic cell fragments locally activate tingible body macrophages in the germinal center
Cell
(IF 66.85)
Pub Date : 2023-03-02
Abigail K. Grootveld, Wunna Kyaw, Veera Panova, Angelica W.Y. Lau, Emily Ashwin, Guillaume Seuzaret, Rama Dhenni, Nayan Deger Bhattacharyya, Weng Hua Khoo, Maté Biro, Tanmay Mitra, Michael Meyer-Hermann, Patrick Bertolino, Masato Tanaka, David A. Hume, Peter I. Croucher, Robert Brink, Akira Nguyen, Oliver Bannard, Tri Giang Phan
Cell lineage-specific mitochondrial resilience during mammalian organogenesis
Cell
(IF 66.85)
Pub Date : 2023-02-23
Stephen P. Burr, Florian Klimm, Angelos Glynos, Malwina Prater, Pamella Sendon, Pavel Nash, Christopher A. Powell, Marie-Lune Simard, Nina A. Bonekamp, Julia Charl, Hector Diaz, Lyuba V. Bozhilova, Yu Nie, Haixin Zhang, Michele Frison, Maria Falkenberg, Nick Jones, Michal Minczuk, James B. Stewart, Patrick F. Chinnery
Bat pluripotent stem cells reveal unusual entanglement between host and viruses
Cell
(IF 66.85)
Pub Date : 2023-02-21
Marion Déjosez, Arturo Marin, Graham M. Hughes, Ariadna E. Morales, Carlos Godoy-Parejo, Jonathan L. Gray, Yiren Qin, Arun A. Singh, Hui Xu, Javier Juste, Carlos Ibáñez, Kris M. White, Romel Rosales, Nancy J. Francoeur, Robert P. Sebra, Dominic Alcock, Thomas L. Volkert, Sébastien J. Puechmaille, Andrzej Pastusiak, Simon D.W. Frost, Thomas P. Zwaka
The choroid plexus links innate immunity to CSF dysregulation in hydrocephalus
Cell
(IF 66.85)
Pub Date : 2023-02-16
Stephanie M. Robert, Benjamin C. Reeves, Emre Kiziltug, Phan Q. Duy, Jason K. Karimy, M. Shahid Mansuri, Arnaud Marlier, Garrett Allington, Ana B.W. Greenberg, Tyrone DeSpenza, Amrita K. Singh, Xue Zeng, Kedous Y. Mekbib, Adam J. Kundishora, Carol Nelson-Williams, Le Thi Hao, Jinwei Zhang, TuKiet T. Lam, Rashaun Wilson, William E. Butler, Kristopher T. Kahle
Hypothalamic neurons that mirror aggression
Cell
(IF 66.85)
Pub Date : 2023-02-15
Taehong Yang, Daniel W. Bayless, Yichao Wei, Dan Landayan, Ivo M. Marcelo, Yangpeng Wang, Laura A. DeNardo, Liqun Luo, Shaul Druckmann, Nirao M. Shah
A molecular device for the redox quality control of GroEL/ES substrates
Cell
(IF 66.85)
Pub Date : 2023-02-09
Emile Dupuy, Sander Egbert Van der Verren, Jiusheng Lin, Mark Alan Wilson, Alix Vincent Dachsbeck, Felipe Viela, Emmanuelle Latour, Alexandra Gennaris, Didier Vertommen, Yves Frédéric Dufrêne, Bogdan Iuliu Iorga, Camille Véronique Goemans, Han Remaut, Jean-François Collet
Cryo-EM structure of the RADAR supramolecular anti-phage defense complex
Cell
(IF 66.85)
Pub Date : 2023-02-09
Brianna Duncan-Lowey, Nitzan Tal, Alex G. Johnson, Shaun Rawson, Megan L. Mayer, Shany Doron, Adi Millman, Sarah Melamed, Taya Fedorenko, Assaf Kacen, Alexander Brandis, Tevie Mehlman, Gil Amitai, Rotem Sorek, Philip J. Kranzusch
The developmental basis of fingerprint pattern formation and variation
Cell
(IF 66.85)
Pub Date : 2023-02-09
James D. Glover, Zoe R. Sudderick, Barbara Bo-Ju Shih, Cameron Batho-Samblas, Laura Charlton, Andrew L. Krause, Calum Anderson, Jon Riddell, Adam Balic, Jinxi Li, Václav Klika, Thomas E. Woolley, Eamonn A. Gaffney, Andrea Corsinotti, Richard A. Anderson, Luke J. Johnston, Sara J. Brown, Sijia Wang, Yuhang Chen, Michael L. Crichton, Denis J. Headon
PIKFYVE inhibition mitigates disease in models of diverse forms of ALS
Cell
(IF 66.85)
Pub Date : 2023-02-07
Shu-Ting Hung, Gabriel R. Linares, Wen-Hsuan Chang, Yunsun Eoh, Gopinath Krishnan, Stacee Mendonca, Sarah Hong, Yingxiao Shi, Manuel Santana, Chuol Kueth, Samantha Macklin-Isquierdo, Sarah Perry, Sarah Duhaime, Claudia Maios, Jonathan Chang, Joscany Perez, Alexander Couto, Jesse Lai, Yichen Li, Samuel V. Alworth, Justin K. Ichida
Structures of LRP2 reveal a molecular machine for endocytosis
Cell
(IF 66.85)
Pub Date : 2023-02-06
Andrew Beenken, Gabriele Cerutti, Julia Brasch, Yicheng Guo, Zizhang Sheng, Hediye Erdjument-Bromage, Zainab Aziz, Shelief Y. Robbins-Juarez, Estefania Y. Chavez, Goran Ahlsen, Phinikoula S. Katsamba, Thomas A. Neubert, Anthony W.P. Fitzpatrick, Jonathan Barasch, Lawrence Shapiro
Touch neurons underlying dopaminergic pleasurable touch and sexual receptivity
Cell
(IF 66.85)
Pub Date : 2023-01-23
Leah J. Elias, Isabella K. Succi, Melanie D. Schaffler, William Foster, Mark A. Gradwell, Manon Bohic, Akira Fushiki, Aman Upadhyay, Lindsay L. Ejoh, Ryan Schwark, Rachel Frazer, Brittany Bistis, Jessica E. Burke, Victoria Saltz, Jared E. Boyce, Anissa Jhumka, Rui M. Costa, Victoria E. Abraira, Ishmail Abdus-Saboor
Lymphatic vessels in bone support regeneration after injury
Cell
(IF 66.85)
Pub Date : 2023-01-19
Lincoln Biswas, Junyu Chen, Jessica De Angelis, Amit Singh, Charlotte Owen-Woods, Zhangfan Ding, Joan Mane Pujol, Naveen Kumar, Fanxin Zeng, Saravana K. Ramasamy, Anjali P. Kusumbe
Immunity to the microbiota promotes sensory neuron regeneration
Cell
(IF 66.85)
Pub Date : 2023-01-13
Michel Enamorado, Warakorn Kulalert, Seong-Ji Han, Indira Rao, Jérémie Delaleu, Verena M. Link, Daniel Yong, Margery Smelkinson, Louis Gil, Saeko Nakajima, Jonathan L. Linehan, Nicolas Bouladoux, Josette Wlaschin, Juraj Kabat, Olena Kamenyeva, Liwen Deng, Inta Gribonika, Alexander T. Chesler, Isaac M. Chiu, Claire E. Le Pichon, Yasmine Belkaid
Structures of the entire human opioid receptor family
Cell
(IF 66.85)
Pub Date : 2023-01-12
Yue Wang, Youwen Zhuang, Jeffrey F. DiBerto, X. Edward Zhou, Gavin P. Schmitz, Qingning Yuan, Manish K. Jain, Weiyi Liu, Karsten Melcher, Yi Jiang, Bryan L. Roth, H. Eric Xu
Loss of epigenetic information as a cause of mammalian aging
Cell
(IF 66.85)
Pub Date : 2023-01-12
Jae-Hyun Yang, Motoshi Hayano, Patrick T. Griffin, João A. Amorim, Michael S. Bonkowski, John K. Apostolides, Elias L. Salfati, Marco Blanchette, Elizabeth M. Munding, Mital Bhakta, Yap Ching Chew, Wei Guo, Xiaojing Yang, Sun Maybury-Lewis, Xiao Tian, Jaime M. Ross, Giuseppe Coppotelli, Margarita V. Meer, Ryan Rogers-Hammond, Daniel L. Vera, David A. Sinclair
Cell-cell metabolite exchange creates a pro-survival metabolic environment that extends lifespan
Cell
(IF 66.85)
Pub Date : 2023-01-05
Clara Correia-Melo, Stephan Kamrad, Roland Tengölics, Christoph B. Messner, Pauline Trebulle, StJohn Townsend, Sreejith Jayasree Varma, Anja Freiwald, Benjamin M. Heineike, Kate Campbell, Lucía Herrera-Dominguez, Simran Kaur Aulakh, Lukasz Szyrwiel, Jason S.L. Yu, Aleksej Zelezniak, Vadim Demichev, Michael Mülleder, Balázs Papp, Mohammad Tauqeer Alam, Markus Ralser
The genetic history of Scandinavia from the Roman Iron Age to the present
Cell
(IF 66.85)
Pub Date : 2023-01-05
Ricardo Rodríguez-Varela, Kristjan H.S. Moore, S. Sunna Ebenesersdóttir, Gulsah Merve Kilinc, Anna Kjellström, Ludvig Papmehl-Dufay, Clara Alfsdotter, Birgitta Berglund, Loey Alrawi, Natalija Kashuba, Verónica Sobrado, Vendela Kempe Lagerholm, Edmund Gilbert, Gianpiero L. Cavalleri, Eivind Hovig, Ingrid Kockum, Tomas Olsson, Lars Alfredsson, Thomas F. Hansen, Thomas Werge, Anders Götherström
Novel integrative elements and genomic plasticity in ocean ecosystems
Cell
(IF 66.85)
Pub Date : 2023-01-05
Thomas Hackl, Raphaël Laurenceau, Markus J. Ankenbrand, Christina Bliem, Zev Cariani, Elaina Thomas, Keven D. Dooley, Aldo A. Arellano, Shane L. Hogle, Paul Berube, Gabriel E. Leventhal, Elaine Luo, John M. Eppley, Ahmed A. Zayed, John Beaulaurier, Ramunas Stepanauskas, Matthew B. Sullivan, Edward F. DeLong, Steven J. Biller, Sallie W. Chisholm
Glucose dissociates DDX21 dimers to regulate mRNA splicing and tissue differentiation
Cell
(IF 66.85)
Pub Date : 2023-01-05
Weili Miao, Douglas F. Porter, Vanessa Lopez-Pajares, Zurab Siprashvili, Robin M. Meyers, Yunhao Bai, Duy T. Nguyen, Lisa A. Ko, Brian J. Zarnegar, Ian D. Ferguson, Matthew M. Mills, Christie E. Jilly-Rehak, Cheng-Guo Wu, Yen-Yu Yang, Jordan M. Meyers, Audrey W. Hong, David L. Reynolds, Muthukumar Ramanathan, Shiying Tao, Sizun Jiang, Paul A. Khavari
Mobile genetic elements from the maternal microbiome shape infant gut microbial assembly and metabolism
Cell
(IF 66.85)
Pub Date : 2022-12-22
Tommi Vatanen, Karolina S. Jabbar, Terhi Ruohtula, Jarno Honkanen, Julian Avila-Pacheco, Heli Siljander, Martin Stražar, Sami Oikarinen, Heikki Hyöty, Jorma Ilonen, Caroline M. Mitchell, Moran Yassour, Suvi M. Virtanen, Clary B. Clish, Damian R. Plichta, Hera Vlamakis, Mikael Knip, Ramnik J. Xavier