Genome-wide CRISPR screening coupled with ATAC-see uncovered modulators that influence global chromatin accessibility. Notably, TFDP1 emerged as a pivotal modulator of chromatin accessibility that acts by controlling histone transcription. Depletion of TFDP1 induced a global elevation in accessibility, enhancing the efficiency of genome editing and iPS cell reprogramming.

中文翻译：

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塑造整体染色质可及性的蛋白质

全基因组 CRISPR 筛选与 ATAC-see 发现的影响全局染色质可及性的调节剂相结合。值得注意的是，TFDP1 成为染色质可及性的关键调节剂，通过控制组蛋白转录发挥作用。TFDP1 的缺失导致可及性的整体升高，从而提高了基因组编辑和 iPS 细胞重编程的效率。