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  • Mortality in biopsy-proven alcohol-related liver disease: a population-based nationwide cohort study of 3453 patients
    Gut (IF 17.943) Pub Date : 2020-03-27
    Hannes Hagström; Maja Thiele; Bjorn Roelstraete; Jonas Söderling; Jonas F Ludvigsson

    Objective Patients with alcohol-related liver disease (ALD) are at increased risk of death, but studies have rarely investigated the significance of histological severity or estimated relative risks compared with a general population. We examined mortality in a nationwide cohort of biopsy-proven ALD. Design Population-based cohort study in Sweden comparing 3453 individuals with an International Classification

    更新日期:2020-03-27
  • Non-invasive diagnosis of patients with ‘at-risk’ NAFLD : only fibrosis counts?
    Gut (IF 17.943) Pub Date : 2020-03-27
    Andreas Geier; Jerome Boursier

    In Gut , Loomba and Adams refer to the recent advances in non-invasive assessment of hepatic fibrosis.1 Not surprisingly, many recent studies in the field were conducted in patients at risk or with clinically diagnosed non-alcoholic fatty liver disease (NAFLD). The implications of non-invasive testing are particularly far reaching in this group of patients since this disease affects 25% of Western

    更新日期:2020-03-27
  • Don’t judge a book by its cover: except during optical evaluation
    Gut (IF 17.943) Pub Date : 2020-03-27
    Neal Shahidi; W Arnout van Hattem; Sergei Vosko; Michael J Bourke

    A healthy 41-year-old female was referred for the endoscopic management of a large rectal laterally spreading lesion (LSL). On index colonoscopy, performed for the evaluation of rectal bleeding, multiple proximal sessile serrated polyps were identified meeting diagnostic criteria for serrated polyposis syndrome. Family history was notable for a sister with a history of sessile serrated polyps. Using

    更新日期:2020-03-27
  • Discontinuation of nucleos(t)ide analogues is not associated with a higher risk of HBsAg seroreversion after antiviral-induced HBsAg seroclearance: a nationwide multicentre study
    Gut (IF 17.943) Pub Date : 2020-03-27
    Minseok Albert Kim; Seung Up Kim; Dong Hyun Sinn; Jeong Won Jang; Young-Suk Lim; Sang Hoon Ahn; Jae-Jun Shim; Yeon Seok Seo; Yang Hyun Baek; Sang Gyune Kim; Young Seok Kim; Ji Hoon Kim; Won Hyeok Choe; Hyung Joon Yim; Hyun Woong Lee; Jung Hyun Kwon; Sung Won Lee; Jae Young Jang; Hwi Young Kim; Yewan Park; Gi-Ae Kim; Hyun Yang; Han Ah Lee; Myeongseok Koh; Young-Sun Lee; Minkoo Kim; Young Chang; Yoon

    Objective Direct comparison of the clinical outcomes between nucleos(t)ide analogue (NA) discontinuation versus NA continuation has not been performed in patients with chronic hepatitis B who achieved HBsAg-seroclearance. Whether NA discontinuation was as safe as NA continuation after NA-induced surface antigen of HBV (HBsAg) seroclearance was investigated in the present study. Designs This multicentre

    更新日期:2020-03-27
  • Organoid cultures of early-onset colorectal cancers reveal distinct and rare genetic profiles
    Gut (IF 17.943) Pub Date : 2020-03-26
    Helen H N Yan; Hoi Cheong Siu; Siu Lun Ho; Sarah S K Yue; Yang Gao; Wai Yin Tsui; Dessy Chan; April S Chan; Jason W H Wong; Alice H Y Man; Bernard C H Lee; Annie S Y Chan; Anthony K W Chan; Ho Sang Hui; Arthur K L Cheung; Wai Lun Law; Oswens S H Lo; Siu Tsan Yuen; Hans Clevers; Suet Yi Leung

    Objective Sporadic early-onset colorectal cancer (EOCRC) has bad prognosis, yet is poorly represented by cell line models. We examine the key mutational and transcriptomic alterations in an organoid biobank enriched in EOCRCs. Design We established paired cancer (n=32) and normal organoids (n=18) from 20 patients enriched in microsatellite-stable EOCRC. Exome and transcriptome analysis was performed

    更新日期:2020-03-27
  • Transmucosal diverticular myotomy for the treatment of oesophageal diverticula associated with spastic motility disorders
    Gut (IF 17.943) Pub Date : 2020-03-26
    Mayenaaz Sidhu; David J Tate; Michael J Bourke

    Thoracic oesophageal diverticula are often associated with spastic motility disorders. Despite correction of the underlying motility disorder, in a subgroup of patients, symptoms persist, primarily regurgitation. Surgical diverticulectomy is then proposed; however, as the approach is thoracoscopic or via thoracotomy, it is associated with significant morbidity and cost. Descriptions of endoscopic techniques

    更新日期:2020-03-27
  • Population impact of direct-acting antiviral treatment on new presentations of hepatitis C-related decompensated cirrhosis: a national record-linkage study
    Gut (IF 17.943) Pub Date : 2020-03-26
    Sharon J Hutchinson; Heather Valerio; Scott A McDonald; Alan Yeung; Kevin Pollock; Shanley Smith; Stephen Barclay; John F Dillon; Raymond Fox; Peter Bramley; Andrew Fraser; Nicholas Kennedy; Rory N Gunson; Kate Templeton; Hamish Innes; Allan McLeod; Amanda Weir; Peter C Hayes; David Goldberg

    Objective Population-based studies demonstrating the clinical impact of interferon-free direct-acting antiviral (DAA) therapies are lacking. We examined the impact of the introduction of DAAs on HCV-related decompensated cirrhosis (DC) through analysis of population-based data from Scotland. Design Through analysis of national surveillance data (involving linkage of HCV diagnosis and clinical databases

    更新日期:2020-03-27
  • Targeting clinical epigenetic reprogramming for chemoprevention of metabolic and viral hepatocellular carcinoma
    Gut (IF 17.943) Pub Date : 2020-03-26
    Frank Jühling; Nourdine Hamdane; Emilie Crouchet; Shen Li; Houssein El Saghire; Atish Mukherji; Naoto Fujiwara; Marine A Oudot; Christine Thumann; Antonio Saviano; Armando Andres Roca Suarez; Kaku Goto; Ricard Masia; Mozhdeh Sojoodi; Gunisha Arora; Hiroshi Aikata; Atsushi Ono; Parissa Tabrizian; Myron Schwartz; Stephen J Polyak; Irwin Davidson; Christian Schmidl; Christoph Bock; Catherine Schuster;

    Objective Hepatocellular carcinoma (HCC) is the fastest-growing cause of cancer-related mortality with chronic viral hepatitis and non-alcoholic steatohepatitis (NASH) as major aetiologies. Treatment options for HCC are unsatisfactory and chemopreventive approaches are absent. Chronic hepatitis C (CHC) results in epigenetic alterations driving HCC risk and persisting following cure. Here, we aimed

    更新日期:2020-03-27
  • Epidemiological, clinical and virological characteristics of 74 cases of coronavirus-infected disease 2019 (COVID-19) with gastrointestinal symptoms
    Gut (IF 17.943) Pub Date : 2020-03-24
    Xi Jin; Jiang-Shan Lian; Jian-Hua Hu; Jianguo Gao; Lin Zheng; Yi-Min Zhang; Shao-Rui Hao; Hong-Yu Jia; Huan Cai; Xiao-Li Zhang; Guo-Dong Yu; Kai-Jin Xu; Xiao-Yan Wang; Jue-Qing Gu; Shan-Yan Zhang; Chan-Yuan Ye; Ci-Liang Jin; Ying-Feng Lu; Xia Yu; Xiao-Peng Yu; Jian-Rong Huang; Kang-Li Xu; Qin Ni; Cheng-Bo Yu; Biao Zhu; Yong-Tao Li; Jun Liu; Hong Zhao; Xuan Zhang; Liang Yu; Yong-Zheng Guo; Jun-Wei Su;

    Objective The SARS-CoV-2-infected disease (COVID-19) outbreak is a major threat to human beings. Previous studies mainly focused on Wuhan and typical symptoms. We analysed 74 confirmed COVID-19 cases with GI symptoms in the Zhejiang province to determine epidemiological, clinical and virological characteristics. Design COVID-19 hospital patients were admitted in the Zhejiang province from 17 January

    更新日期:2020-03-26
  • Adenoma detection by Endocuff-assisted versus standard colonoscopy in routine practice: a cluster-randomised crossover trial
    Gut (IF 17.943) Pub Date : 2020-03-24
    David Karsenti; Gaelle Tharsis; Bastien Perrot; Philippe Cattan; Gilles Tordjman; Franck Venezia; Elie Zrihen; Dominique Gillot; Agnes Gillet; Charles Hagege; Joelle Samama; Isabelle Etienney; Jean-Philippe Lab; Bernard Guigui; Jacqueline Zago; Bouchra Benkessou; Pascal Burtin; Maryan Cavicchi

    Objective Endocuff Vision (ECV) is the second generation of a device designed to improve polyp detection. The aim of this study was to evaluate its impact on adenoma detection rate (ADR) in routine colonoscopy. Design This cluster-randomised crossover trial compared Endocuff-assisted (ECV+) with standard (ECV-) colonoscopy. Two teams of 11 endoscopists each with prior ECV experience, balanced in terms

    更新日期:2020-03-26
  • Pharmacological treatment of opioid-induced constipation: moving ahead to new targets
    Gut (IF 17.943) Pub Date : 2020-03-24
    Fabio Lugoboni; Federico Vignoni; Stefano Tamburin

    We read with great interest the systematic review and network meta-analysis on pharmacological treatments for opioid-induced constipation (OIC).1 Based on 27 randomised controlled trials (RCTs, 9149 patients), the authors concluded that peripherally acting mu-opioid receptor antagonists (PAMORAs) and the prokinetic prucalopride were all more effective than placebo for OIC and that naloxone and naldemedine

    更新日期:2020-03-26
  • Bile acid composition regulates GPR119-dependent intestinal lipid sensing and food intake regulation in mice.
    Gut (IF 17.943) Pub Date : 2020-02-28
    Sei Higuchi,Tiara Rinjani Ahmad,Donovan A Argueta,Pedro A Perez,Chen Zhao,Gary J Schwartz,Nicholas DiPatrizio,Rebecca Haeusler

    OBJECTIVES Lipid mediators in the GI tract regulate satiation and satiety. Bile acids (BAs) regulate the absorption and metabolism of dietary lipid in the intestine, but their effects on lipid-regulated satiation and satiety are completely unknown. Investigating this is challenging because introducing excessive BAs or eliminating BAs strongly impacts GI functions. We used a mouse model (Cyp8b1-/- mice)

    更新日期:2020-03-24
  • Helicobacter pylori eradication therapy to prevent gastric cancer: systematic review and meta-analysis
    Gut (IF 17.943) Pub Date : 2020-03-23
    Alexander Charles Ford; Yuhong Yuan; Paul Moayyedi

    Objectives Gastric cancer is strongly associated with Helicobacter pylori ( H. pylori ). We conducted a previous systematic review and meta-analysis that suggested eradication therapy reduced future incidence of gastric cancer, but effect size was uncertain, and there was no reduction in gastric cancer-related mortality. We updated this meta-analysis, as more data has accumulated. We also evaluated

    更新日期:2020-03-24
  • Prevention of endpoints in primary biliary cholangitis with ursodeoxycholic acid: quantifying the benefit
    Gut (IF 17.943) Pub Date : 2020-03-23
    Jörn M Schattenberg

    Ursodeoxycholic acid (UDCA) is a hydrophilic bile acid with an established benefit for patients suffering from primary biliary cholangitis (PBC). It was first introduced in the 60s and took until the late 90s to demonstrate a survival benefit in large meta-cohort studies.1 Since then, UDCA is the established first-line therapy according to current guidelines.2 The benefit of UDCA is multidimensional

    更新日期:2020-03-24
  • Intestinal gluconeogenesis prevents obesity-linked liver steatosis and non-alcoholic fatty liver disease
    Gut (IF 17.943) Pub Date : 2020-03-23
    Justine Vily-Petit; Maud Soty-Roca; Marine Silva; Margaux Raffin; Amandine Gautier-Stein; Fabienne Rajas; Gilles Mithieux

    Objective Hepatic steatosis accompanying obesity is a major health concern, since it may initiate non-alcoholic fatty liver disease (NAFLD) and associated complications like cirrhosis or cancer. Intestinal gluconeogenesis (IGN) is a recently described function that contributes to the metabolic benefits of specific macronutrients as protein or soluble fibre, via the initiation of a gut-brain nervous

    更新日期:2020-03-24
  • SARS-CoV-2 induced diarrhoea as onset symptom in patient with COVID-19
    Gut (IF 17.943) Pub Date : 2020-03-22
    Y Song; P Liu; X L Shi; Y L Chu; J Zhang; J Xia; X Z Gao; T Qu; M Y Wang

    We read with great interest the recent publication by Kumar et al , concerning gastrointestinal tract (GIT) symptoms (vomiting, diarrhoea and abdominal pain) among hospitalised children admitted with H1N1 influenza A virus infection.1 They have concluded that patients with GIT symptoms should not be ignored for the virus infectivity, especially during the outbreak period. Now the coronavirus disease

    更新日期:2020-03-24
  • COVID-19 in gastroenterology: a clinical perspective
    Gut (IF 17.943) Pub Date : 2020-03-20
    John Ong; Barnaby Edward Young; Sharon Ong

    We read with interest the article ‘Diarrhoea may be underestimated: a missing link in 2019 novel coronavirus’ by Liang et al .1 Indeed, we agree with the authors that diarrhoea may be an underestimated and under-reported symptom of coronavirus disease 2019 (COVID-19). Similar to data from China, fever and cough are the two most commonly reported symptoms of COVID-19 in Singapore; around 30% of cases

    更新日期:2020-03-21
  • Treatment of severe acute malnutrition with oat or standard ready-to-use therapeutic food: a triple-blind, randomised controlled clinical trial
    Gut (IF 17.943) Pub Date : 2020-03-16
    David Taylor Hendrixson; Claire Godbout; Alyssa Los; Meghan Callaghan-Gillespie; Melody Mui; Donna Wegner; Taylor Bryant; Aminata Koroma; Mark J Manary

    Objective We hypothesised that an alternative RUTF (ready-to-use therapeutic food) made with oats (oat-RUTF) would be non-inferior to standard RUTF (s-RUTF). Design This was a randomised, triple-blind, controlled, clinical non-inferiority trial comparing oat-RUTF to s-RUTF in rural Sierra Leone. Children aged 6–59 months with severe acute malnutrition (SAM) were randomised to oat-RUTF or s-RUTF. s-RUTF

    更新日期:2020-03-16
  • Aggressive case of early onset gastric cancer; identifying the knowledge gap
    Gut (IF 17.943) Pub Date : 2020-03-16
    Jennifer M Kolb; Stephen Leong; Lindsey M Westbrook; Swati G Patel

    A woman aged 30 years was referred for endoscopy for iron deficiency anaemia. Colonoscopy was normal. Upper endoscopy demonstrated multiple small, carpet-like, sessile polyps in the gastric fundus and a larger 4 cm polyp in the body (figure 1). The duodenum was normal without polyps. Endoscopic ultrasound demonstrated a 35×36 mm hypoechoic polypoid lesion arising from the mucosa and invading into the

    更新日期:2020-03-16
  • Challenges and opportunities for IBD drug development: from early stage to regulatory approval
    Gut (IF 17.943) Pub Date : 2020-03-16
    Silvio Danese; Elmer Schabel; Mark Andrew Ainsworth; Laurent Peyrin-Biroulet

    Increased understanding of the immunopathology of inflammatory bowel disease (IBD) has resulted in the development of novel therapies such as vedolizumab or ustekinumab, and the investigation of new agents including Janus kinase inhibitors, anti-mucosal vascular addressin cell adhesion molecule-1 agents, anti-interleukin-12/23 monoclonal antibody and sphingosine-1-phosphate receptor-1 selective agonists

    更新日期:2020-03-16
  • Mediterranean diet, gut microbiota and health: when age and calories do not add up!
    Gut (IF 17.943) Pub Date : 2020-03-13
    Patrice D Cani; Matthias Van Hul

    A healthy diet is generally recognised as a diet that supports the physiological and energetic requirements of the body and provides sufficient, though not excessive, amounts of micronutrients and macronutrients. Despite this self-evident definition, the implementation of this basic principle has proven very difficult in modern western society. The benefits of adopting a Mediterranean diet (MedDiet)

    更新日期:2020-03-16
  • A purified membrane protein from Akkermansia muciniphila or the pasteurised bacterium blunts colitis associated tumourigenesis by modulation of CD8+ T cells in mice
    Gut (IF 17.943) Pub Date : 2020-03-13
    Lijuan Wang; Lei Tang; Yiming Feng; Suying Zhao; Mei Han; Chuan Zhang; Gehui Yuan; Jun Zhu; Shuyuan Cao; Qian Wu; Lei Li; Zhan Zhang

    Objective Gut microbiota have been linked to inflammatory bowel disease (IBD) and colorectal cancer (CRC). Akkermansia muciniphila ( A. muciniphila ) is a gram-negative anaerobic bacterium that is selectively decreased in the faecal microbiota of patients with IBD, but its causative role and molecular mechanism in blunting colitis-associated colorectal cancer (CAC) remain inconclusive. This study investigates

    更新日期:2020-03-16
  • Changing TACTICS in intermediate HCC: TACE plus sorafenib
    Gut (IF 17.943) Pub Date : 2020-03-13
    Pompilia Radu; Jean-François Dufour

    Hepatocellular carcinoma (HCC) represents a serious health problem, mainly due to the high cancer-related mortality. Transarterial chemoembolisation (TACE) is currently used as the first-line treatment for intermediate-stage HCC (Barcelona Clinic Liver Cancer (BCLC) stage B), despite the fact that this stage comprises patients with a wide range of liver function, variable tumour number and size.1–4

    更新日期:2020-03-16
  • Faecal virome transplantation decreases symptoms of type 2 diabetes and obesity in a murine model
    Gut (IF 17.943) Pub Date : 2020-03-12
    Torben Sølbeck Rasmussen; Caroline Märta Junker Mentzel; Witold Kot; Josué Leonardo Castro-Mejía; Simone Zuffa; Jonathan Richard Swann; Lars Hestbjerg Hansen; Finn Kvist Vogensen; Axel Kornerup Hansen; Dennis Sandris Nielsen

    Objective Development of obesity and type 2 diabetes (T2D) are associated with gut microbiota (GM) changes. The gut viral community is predominated by bacteriophages (phages), which are viruses that attack bacteria in a host-specific manner. The antagonistic behaviour of phages has the potential to alter the GM. As a proof-of-concept, we demonstrate the efficacy of faecal virome transplantation (FVT)

    更新日期:2020-03-12
  • Endosonography-guided gallbladder drainage versus percutaneous cholecystostomy in very high-risk surgical patients with acute cholecystitis: an international randomised multicentre controlled superiority trial (DRAC 1)
    Gut (IF 17.943) Pub Date : 2020-03-12
    Anthony Y B Teoh; Masayuki Kitano; Takao Itoi; Manuel Pérez-Miranda; Takeshi Ogura; Shannon Melissa Chan; Carlos Serna-Higuera; Shunsuke Omoto; Raul Torres-Yuste; Takayoshi Tsuichiya; Ka Tak Wong; Chi-Ho Leung; Philip Wai Yan Chiu; Enders Kwok Wai Ng; James Yun Wong Lau

    Objective The optimal management of acute cholecystitis in patients at very high risk for cholecystectomy is uncertain. The aim of the current study was to compare endoscopic ultrasound (EUS)-guided gallbladder drainage (EUS-GBD) to percutaneous cholecystostomy (PT-GBD) as a definitive treatment in these patients under a randomised controlled trial. Design Consecutive patients suffering from acute

    更新日期:2020-03-12
  • Seven-day vonoprazan and low-dose amoxicillin dual therapy as first-line Helicobacter pylori treatment: a multicentre randomised trial in Japan.
    Gut (IF 17.943) Pub Date : 2020-01-08
    Sho Suzuki,Takuji Gotoda,Chika Kusano,Hisatomo Ikehara,Ryoji Ichijima,Motoki Ohyauchi,Hirotaka Ito,Masashi Kawamura,Yohei Ogata,Masahiko Ohtaka,Moriyasu Nakahara,Koichi Kawabe

    OBJECTIVE To date, no randomised trials have compared the efficacy of vonoprazan and amoxicillin dual therapy with other standard regimens for Helicobacter pylori treatment. This study aimed to investigate the efficacy of the 7-day vonoprazan and low-dose amoxicillin dual therapy as a first-line H. pylori treatment, and compared this with vonoprazan-based triple therapy. DESIGN This prospective, randomised

    更新日期:2020-03-10
  • Are we ready for targeted therapy combinations in HCC?
    Gut (IF 17.943) Pub Date : 2020-01-08
    Einat Cinnamon,Eli Pikarsky

    Treatment options for advanced hepatocellular carcinoma (HCC) are limited. Although some multikinase inhibitors such as sorafenib show some benefit, this does not significantly alter the course of disease for most patients. Currently, several multikinase inhibitors were shown to work in first-line or second-line treatments, but the overall benefit is quite small. Thus, we urgently need to find ways

    更新日期:2020-03-06
  • Real-time use of artificial intelligence in the evaluation of cancer in Barrett’s oesophagus
    Gut (IF 17.943) Pub Date : 2020-04-01
    Alanna Ebigbo; Robert Mendel; Andreas Probst; Johannes Manzeneder; Friederike Prinz; Luis A de Souza Jr.; Joao Papa; Christoph Palm; Helmut Messmann

    Based on previous work by our group with manual annotation of visible Barrett oesophagus (BE) cancer images, a real-time deep learning artificial intelligence (AI) system was developed. While an expert endoscopist conducts the endoscopic assessment of BE, our AI system captures random images from the real-time camera livestream and provides a global prediction (classification), as well as a dense prediction

    更新日期:2020-03-06
  • Non-steroidal anti-inflammatory drug (NSAID) therapy in patients with hypertension, cardiovascular, renal or gastrointestinal comorbidities: joint APAGE/APLAR/APSDE/APSH/APSN/PoA recommendations.
    Gut (IF 17.943) Pub Date : 2020-01-14
    Cheuk-Chun Szeto,Kentaro Sugano,Ji-Guang Wang,Kazuma Fujimoto,Samuel Whittle,Gopesh K Modi,Chen-Huen Chen,Jeong-Bae Park,Lai-Shan Tam,Kriengsak Vareesangthip,Kelvin K F Tsoi,Francis K L Chan

    BACKGROUND Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most commonly prescribed medications, but they are associated with a number of serious adverse effects, including hypertension, cardiovascular disease, kidney injury and GI complications. OBJECTIVE To develop a set of multidisciplinary recommendations for the safe prescription of NSAIDs. METHODS Randomised control trials and observational

    更新日期:2020-03-06
  • Master transcription factors form interconnected circuitry and orchestrate transcriptional networks in oesophageal adenocarcinoma
    Gut (IF 17.943) Pub Date : 2020-04-01
    Li Chen; Moli Huang; Jasmine Plummer; Jian Pan; Yan Yi Jiang; Qian Yang; Tiago Chedraoui Silva; Nicole Gull; Stephanie Chen; Ling Wen Ding; Omer An; Henry Yang; Yulan Cheng; Jonathan W Said; Ngan Doan; Winand NM Dinjens; Kevin M Waters; Richard Tuli; Simon A Gayther; Samuel J Klempner; Benjamin P Berman; Stephen J Meltzer; De-Chen Lin; H Phillip Koeffler

    Objective While oesophageal squamous cell carcinoma remains infrequent in Western populations, the incidence of oesophageal adenocarcinoma (EAC) has increased sixfold to eightfold over the past four decades. We aimed to characterise oesophageal cancer-specific and subtypes-specific gene regulation patterns and their upstream transcription factors (TFs). Design To identify regulatory elements, we profiled

    更新日期:2020-03-06
  • Meta-analysis of genome-wide association studies and functional assays decipher susceptibility genes for gastric cancer in Chinese populations
    Gut (IF 17.943) Pub Date : 2020-04-01
    Caiwang Yan; Meng Zhu; Yanbing Ding; Ming Yang; Mengyun Wang; Gang Li; Chuanli Ren; Tongtong Huang; Wenjun Yang; Bangshun He; Meilin Wang; Fei Yu; Jinchen Wang; Ruoxin Zhang; Tianpei Wang; Jing Ni; Jiaping Chen; Yue Jiang; Juncheng Dai; Erbao Zhang; Hongxia Ma; Yanong Wang; Dazhi Xu; Shukui Wang; Yun Chen; Zekuan Xu; Jianwei Zhou; Guozhong Ji; Zhaoming Wang; Zhengdong Zhang; Zhibin Hu; Qingyi Wei;

    Objective Although a subset of genetic loci have been associated with gastric cancer (GC) risk, the underlying mechanisms are largely unknown. We aimed to identify new susceptibility genes and elucidate their mechanisms in GC development. Design We conducted a meta-analysis of four genome-wide association studies (GWASs) encompassing 3771 cases and 5426 controls. After targeted sequencing and functional

    更新日期:2020-03-06
  • Prevention of recurrent idiopathic gastroduodenal ulcer bleeding: a double-blind, randomised trial
    Gut (IF 17.943) Pub Date : 2020-04-01
    Grace L H Wong; Louis H S Lau; Jessica Y L Ching; Yee-Kit Tse; Rachel H Y Ling; Vincent W S Wong; Philip W Y Chiu; James Y W Lau; Francis K L Chan

    Objective Patients with a history of Helicobacter pylori -negative idiopathic bleeding ulcers have a considerable risk of recurrent ulcer complications. We hypothesised that a proton pump inhibitor (lansoprazole) is superior to a histamine 2 receptor antagonist (famotidine) for the prevention of recurrent ulcer bleeding in such patients. Design In this industry-independent, double-blind, randomised

    更新日期:2020-03-06
  • Tight control for Crohn’s disease with adalimumab-based treatment is cost-effective: an economic assessment of the CALM trial
    Gut (IF 17.943) Pub Date : 2020-04-01
    Remo Panaccione; Jean-Frederic Colombel; Simon P L Travis; Peter Bossuyt; Filip Baert; Tomáš Vaňásek; Ahmet Danalıoğlu; Gottfried Novacek; Alessandro Armuzzi; Walter Reinisch; Scott Johnson; Marric Buessing; Ezequiel Neimark; Joel Petersson; Wan-Ju Lee; Geert R D’Haens

    Objective To evaluate the cost-effectiveness of an inflammatory biomarker and clinical symptom directed tight control strategy (TC) compared with symptom-based clinical management (CM) in patients with Crohn’s disease (CD) naïve to immunosuppressants and biologics using a UK public payer perspective. Design A regression model estimated weekly CD Activity Index (CDAI)-based transition matrices (remission:

    更新日期:2020-03-06
  • Alterations of the bile microbiome in primary sclerosing cholangitis
    Gut (IF 17.943) Pub Date : 2020-04-01
    Timur Liwinski; Roman Zenouzi; Clara John; Hanno Ehlken; Malte C Rühlemann; Corinna Bang; Stefan Groth; Wolfgang Lieb; Marcus Kantowski; Nils Andersen; Guido Schachschal; Tom H Karlsen; Johannes R Hov; Thomas Rösch; Ansgar W Lohse; Joerg Heeren; Andre Franke; Christoph Schramm

    Background Patients with primary sclerosing cholangitis (PSC) display an altered colonic microbiome compared with healthy controls. However, little is known on the bile duct microbiome and its interplay with bile acid metabolism in PSC. Methods Patients with PSC (n=43) and controls without sclerosing cholangitis (n=22) requiring endoscopic retrograde cholangiography were included prospectively. Leading

    更新日期:2020-03-06
  • Endoscopic mucosal resection is effective for laterally spreading lesions at the anorectal junction
    Gut (IF 17.943) Pub Date : 2020-04-01
    Neal Shahidi; Mayenaaz Sidhu; Sergei Vosko; W Arnout van Hattem; Iddo Bar-Yishay; Scott Schoeman; David J Tate; Bronte Holt; Luke F Hourigan; Eric YT Lee; Nicholas G Burgess; Michael J Bourke

    Objective The optimal approach for removing large laterally spreading lesions at the anorectal junction (ARJ-LSLs) is unknown. Endoscopic mucosal resection (EMR) is a definitive therapy for colorectal LSLs. It is unclear whether it is an effective modality for ARJ-LSLs. Design EMR outcomes for ARJ-LSLs (distal margin of ≤20 mm from the dentate line) in comparison with rectal LSLs (distal margin of

    更新日期:2020-03-06
  • Artificial intelligence-guided tissue analysis combined with immune infiltrate assessment predicts stage III colon cancer outcomes in PETACC08 study
    Gut (IF 17.943) Pub Date : 2020-04-01
    Cynthia Reichling; Julien Taieb; Valentin Derangere; Quentin Klopfenstein; Karine Le Malicot; Jean-Marc Gornet; Hakim Becheur; Francis Fein; Oana Cojocarasu; Marie Christine Kaminsky; Jean Paul Lagasse; Dominique Luet; Suzanne Nguyen; Pierre-Luc Etienne; Mohamed Gasmi; Andre Vanoli; Hervé Perrier; Pierre-Laurent Puig; Jean-François Emile; Come Lepage; François Ghiringhelli

    Objective Diagnostic tests, such as Immunoscore, predict prognosis in patients with colon cancer. However, additional prognostic markers could be detected on pathological slides using artificial intelligence tools. Design We have developed a software to detect colon tumour, healthy mucosa, stroma and immune cells on CD3 and CD8 stained slides. The lymphocyte density and surface area were quantified

    更新日期:2020-03-06
  • High-dimensional cytometric analysis of colorectal cancer reveals novel mediators of antitumour immunity
    Gut (IF 17.943) Pub Date : 2020-04-01
    Natasja L de Vries; Vincent van Unen; Marieke E Ijsselsteijn; Tamim Abdelaal; Ruud van der Breggen; Arantza Farina Sarasqueta; Ahmed Mahfouz; Koen C M J Peeters; Thomas Höllt; Boudewijn P F Lelieveldt; Frits Koning; Noel F C C de Miranda

    Objective A comprehensive understanding of anticancer immune responses is paramount for the optimal application and development of cancer immunotherapies. We unravelled local and systemic immune profiles in patients with colorectal cancer (CRC) by high-dimensional analysis to provide an unbiased characterisation of the immune contexture of CRC. Design Thirty-six immune cell markers were simultaneously

    更新日期:2020-03-06
  • Kras and Lkb1 mutations synergistically induce intraductal papillary mucinous neoplasm derived from pancreatic duct cells
    Gut (IF 17.943) Pub Date : 2020-04-01
    Louis Collet; Elsa Ghurburrun; Nora Meyers; Mohamad Assi; Boris Pirlot; Isabelle A Leclercq; Anne Couvelard; Mina Komuta; Jérôme Cros; Pieter Demetter; Frédéric P Lemaigre; Ivan Borbath; Patrick Jacquemin

    Objective Pancreatic cancer can arise from precursor lesions called intraductal papillary mucinous neoplasms (IPMN), which are characterised by cysts containing papillae and mucus-producing cells. The high frequency of KRAS mutations in IPMN and histological analyses suggest that oncogenic KRAS drives IPMN development from pancreatic duct cells. However, induction of Kras mutation in ductal cells is

    更新日期:2020-03-06
  • Loss of Setd2 promotes Kras-induced acinar-to-ductal metaplasia and epithelia–mesenchymal transition during pancreatic carcinogenesis
    Gut (IF 17.943) Pub Date : 2020-04-01
    Ningning Niu; Ping Lu; Yanlin Yang; Ruizhe He; Li Zhang; Juanjuan Shi; Jinghua Wu; Minwei Yang; Zhi-Gang Zhang; Li-Wei Wang; Wei-Qiang Gao; Aida Habtezion; Gary Guishan Xiao; Yongwei Sun; Li Li; Jing Xue

    Objective SETD2, the sole histone H3K36 trimethyltransferase, is frequently mutated or deleted in human cancer, including pancreatic ductal adenocarcinoma (PDAC). However, whether SETD2/H3K36me3 alteration results in PDAC remains largely unknown. Design TCGA(PAAD) public database and PDAC tissue array with SETD2/H3K36me3 staining were used to investigate the clinical relevance of SETD2 in PDAC. Furthermore

    更新日期:2020-03-06
  • CDK12 inhibition mediates DNA damage and is synergistic with sorafenib treatment in hepatocellular carcinoma
    Gut (IF 17.943) Pub Date : 2020-04-01
    Cun Wang; Hui Wang; Cor Lieftink; Aimee du Chatinier; Dongmei Gao; Guangzhi Jin; Haojie Jin; Roderick L Beijersbergen; Wenxin Qin; René Bernards

    Objectives Hepatocellular carcinoma (HCC) is one of the most frequent malignancies and a major leading cause of cancer-related deaths worldwide. Several therapeutic options like sorafenib and regorafenib provide only modest survival benefit to patients with HCC. This study aims to identify novel druggable candidate genes for patients with HCC. Design A non-biased CRISPR (clustered regularly interspaced

    更新日期:2020-03-06
  • Adeno-associated virus in the liver: natural history and consequences in tumour development
    Gut (IF 17.943) Pub Date : 2020-04-01
    Tiziana La Bella; Sandrine Imbeaud; Camille Peneau; Iadh Mami; Shalini Datta; Quentin Bayard; Stefano Caruso; Theo Z Hirsch; Julien Calderaro; Guillaume Morcrette; Catherine Guettier; Valerie Paradis; Giuliana Amaddeo; Alexis Laurent; Laurent Possenti; Laurence Chiche; Paulette Bioulac-Sage; Jean-Frederic Blanc; Eric Letouze; Jean-Charles Nault; Jessica Zucman-Rossi

    Objective Adeno-associated virus (AAV) is a defective mono-stranded DNA virus, endemic in human population (35%–80%). Recurrent clonal AAV2 insertions are associated with the pathogenesis of rare human hepatocellular carcinoma (HCC) developed on normal liver. This study aimed to characterise the natural history of AAV infection in the liver and its consequence in tumour development. Design Viral DNA

    更新日期:2020-03-06
  • Non-coding RNAs in GI cancers: from cancer hallmarks to clinical utility.
    Gut (IF 17.943) Pub Date : 2020-02-07
    Mihnea Paul Dragomir,Scott Kopetz,Jaffer A Ajani,George Adrian Calin

    One of the most unexpected discoveries in molecular oncology, in the last decades, was the identification of a new layer of protein coding gene regulation by transcripts that do not codify for proteins, the non-coding RNAs. These represent a heterogeneous category of transcripts that interact with many types of genetic elements, including regulatory DNAs, coding and other non-coding transcripts and

    更新日期:2020-03-06
  • Recent advances in alcohol-related liver disease (ALD): summary of a Gut round table meeting.
    Gut (IF 17.943) Pub Date : 2019-12-26
    Matias A Avila,Jean-François Dufour,Alexander L Gerbes,Fabien Zoulim,Ramon Bataller,Patrizia Burra,Helena Cortez-Pinto,Bin Gao,Ian Gilmore,Philippe Mathurin,Christophe Moreno,Vladimir Poznyak,Bernd Schnabl,Gyongyi Szabo,Maja Thiele,Mark R Thursz

    Alcohol-related liver disease (ALD), which includes a range of disorders of different severity and is one of the most prevalent types of liver disease worldwide, has recently regained increased attention. Among other reasons, the realisation that any alcohol intake, regardless of type of beverage represents a health risk, and the new therapeutic strategies tested in recently published or undergoing

    更新日期:2020-03-06
  • GI highlights from the literature
    Gut (IF 17.943) Pub Date : 2020-04-01
    Philip J Smith

    ### Manipulation of the gut microbiome to treat alcoholic hepatitis Duan Y, Llorente C, Lang S, et al . Bacteriophage targeting of gut bacterium attenuates alcoholic liver disease. Nature 2019;575:505–511. Alcoholic hepatitis (AH) is a severe manifestation of alcohol-associated liver disease with limited therapeutic options and a high associated mortality. While perturbation of the gut microbiota and

    更新日期:2020-03-06
  • Reducing the number of surveillance colonoscopies with faecal immunochemical tests
    Gut (IF 17.943) Pub Date : 2020-04-01
    Erin L Symonds; Kathryn Cornthwaite; Robert J L Fraser; Peter Bampton; Charles Cock; Graeme P Young

    We read with interest the article by Cross et al ,1 which examined the use of FIT in intermediate risk patients undergoing 3 yearly surveillance colonoscopies. The investigators assessed the diagnostic accuracy of this approach, together with the number of advanced adenomas and colorectal cancers missed, and the potential cost savings. The results indicate that replacing 3 yearly colonoscopy with annual

    更新日期:2020-03-06
  • Most unambiguous loss-of-function CPA1 mutations are unlikely to predispose to chronic pancreatitis
    Gut (IF 17.943) Pub Date : 2020-04-01
    Jin-Huan Lin; Arnaud Boulling; Emmanuelle Masson; David N Cooper; Zhao-Shen Li; Claude Férec; Zhuan Liao; Jian-Min Chen

    We have read with interest the recent publication of Hegyi and Sahin-Tóth1 reporting that chronic pancreatitis (CP)-predisposing CPA1 mutations function through the misfolding pathway rather than through loss of CPA1 protein/activity. Herein, we explore an additional insight gleaned from this study beyond those discussed in an accompanying Editorial.2 In the original study reporting the association

    更新日期:2020-03-06
  • Hepatitis D: not a rare disease anymore: global update for 2017–2018
    Gut (IF 17.943) Pub Date : 2020-04-01
    Dan-Ting Shen; Dong-Ze Ji; Hai-Yan Chen; Hemant Goyal; Shiyang Pan; Hua-Guo Xu

    We sincerely appreciate Stockdale and colleagues1 for their critical consideration of our article. Herein, we tried to answer their concerns about the methodology of our meta-analysis.2 We used hepatitis D virus (HDV) antibody (both IgM and IgG) seropositivity as a measure of overall burden of HDV seroprevalence. Although anti-HDV IgM Ab assays may fail to detect low titres of antibodies and underestimate

    更新日期:2020-03-06
  • Scoring endoscopic disease activity in IBD: artificial intelligence sees more and better than we do
    Gut (IF 17.943) Pub Date : 2020-04-01
    Peter Bossuyt; Séverine Vermeire; Raf Bisschops

    With great interest we read the review article of Iacucci et al on advanced endoscopic techniques in IBD.1 The authors clearly recognise the current limitations of the different endoscopic scoring tools for disease activity in IBD and provide potential solutions with new advanced techniques. We fully agree that interobserver variability is problematic for treatment planning and IBD drug development

    更新日期:2020-03-06
  • Response to: ‘Circulating microbiome in blood of different circulatory compartments’ by Schierwagen et al
    Gut (IF 17.943) Pub Date : 2020-04-01
    Bastian Volker Helmut Hornung; Romy Danielle Zwittink; Quinten Raymond Ducarmon; Ed J Kuijper

    We read with interest the article by Schierwagen et al ,1 who reported on their findings regarding the blood microbiome. Since our research group is working in a hospital setting, recently, we have also considered investigating the blood microbiome using collected blood samples that are potentially available. However, based on recent literature,2 3 we considered the presence of a blood microbiome very

    更新日期:2020-03-06
  • Novel p.K374E variant of CPA1 causes misfolding-induced hereditary pancreatitis with autosomal dominant inheritance
    Gut (IF 17.943) Pub Date : 2020-04-01
    Balázs Csaba Németh; Anna Orekhova; Wenying Zhang; Shannon A Nortman; Tyler Thompson; Péter Hegyi; Maisam Abu-El-Haija

    We read the publication written by Lin et al 1 with great interest. The authors suggest that the majority of functionally defective carboxypeptidase A1 ( CPA1) mutations can elicit reduced expression due to nonsense-mediated decay (NMD) and therefore, only a small subset of the earlier reported CPA1 variants2 will predispose to chronic pancreatitis (CP) via the misfolding-dependent pathway.3 This paper

    更新日期:2020-03-06
  • Concerns regarding the recommendations of the British Society of Gastroenterology’s lower GI bleeding guidelines
    Gut (IF 17.943) Pub Date : 2020-04-01
    Ajay M Verma; Neeraj Bhala; Andrew Chilton; Benjamin R Disney

    We are writing with regard to the recently published British Society of Gastroenterology (BSG) lower GI bleeding (LGIB) guidelines.1 We have significant concerns about some of the recommendations. The quick reference flowchart suggests that patients with stable LGIB (shock index <1), classed as having a major (risk scored) bleed, should be admitted for a lower GI endoscopy on the next available list

    更新日期:2020-03-06
  • Degree of STING activation is associated with disease outcomes
    Gut (IF 17.943) Pub Date : 2020-04-01
    Qiongyuan Hu; Jie Wu; Yanhan Ren; Xiuwen Wu; Lin Gao; Gefei Wang; Guosheng Gu; Huajian Ren; Zhiwu Hong; Dominic A Slade; Jianan Ren

    We read with interest the recent paper by Zhao et al ,1 which reported that stimulator of interferon genes (STING) signalling alleviated chronic pancreatitis (CP)-induced inflammation and fibrosis. There is increasing evidence that STING activation could lead to inflammatory response and fibrosis. In our opinion, this contention is associated with three major issues: the form of stimulators that activate

    更新日期:2020-03-06
  • Recurrent bacteraemia following variceal haemorrhage
    Gut (IF 17.943) Pub Date : 2020-04-01
    Rooshi Nathwani; Benjamin H Mullish; David Kockerling; Nikil Rajani; Ameet Dhar

    A 43-year-old man presented to the hospital with septic shock. Eight weeks prior, he had experienced recurrent gastric variceal bleeding (figure 1), treated initially with cyanoacrylate glue injection. Abdominal CT scan suggested features of chronic liver disease, with non-alcoholic fatty liver disease being the presumed aetiology. Despite endoscopic therapy, he had further variceal haemorrhage, and

    更新日期:2020-03-06
  • TGF-β2 silencing to target biliary-derived liver diseases.
    Gut (IF 17.943) Pub Date : 2020-01-28
    Anne Dropmann,Steven Dooley,Bedair Dewidar,Seddik Hammad,Tatjana Dediulia,Julia Werle,Vanessa Hartwig,Shahrouz Ghafoory,Stefan Woelfl,Hanna Korhonen,Michel Janicot,Katja Wosikowski,Timo Itzel,Andreas Teufel,Detlef Schuppan,Ana Stojanovic,Adelheid Cerwenka,Stefanie Nittka,Albrecht Piiper,Timo Gaiser,Naiara Beraza,Malgorzata Milkiewicz,Piotr Milkiewicz,John G Brain,David E J Jones,Thomas S Weiss,Ulrich

    OBJECTIVE TGF-β2 (TGF-β, transforming growth factor beta), the less-investigated sibling of TGF-β1, is deregulated in rodent and human liver diseases. Former data from bile duct ligated and MDR2 knockout (KO) mouse models for human cholestatic liver disease suggested an involvement of TGF-β2 in biliary-derived liver diseases. DESIGN As we also found upregulated TGFB2 in liver tissue of patients with

    更新日期:2020-03-06
  • Characterisation of innate lymphoid cell subsets infiltrating colorectal carcinoma
    Gut (IF 17.943) Pub Date : 2020-03-05
    Paolo Carrega; Paola Orecchia; Linda Quatrini; Nicola Tumino; Roberta Venè; Roberto Benelli; Alessandro Poggi; Stefano Scabini; Maria Cristina Mingari; Lorenzo Moretta; Paola Vacca

    We read with great interest the paper by de Vries et al 1 which provides an interesting and unbiased characterisation of the immune contexture of colorectal cancer (CRC), the third most common cancer worldwide.2 By mass cytometric analysis together with single cell RNA sequencing, the authors identified several clusters of immune cells infiltrating CRC. They show that natural killer (NK) cells (identified

    更新日期:2020-03-05
  • Microbiome alterations in IBS
    Gut (IF 17.943) Pub Date : 2020-03-05
    Ian B Jeffery; Eileen O'Herlihy; Fergus Shanahan; Paul W O' Toole

    We commend the editors of Gut for publishing the article by Hugerth et al 1 given that negative results are conspicuously missing from the microbiome literature. The paper reports that in a randomly recruited Swedish cohort of individuals meeting Rome IV criteria for irritable bowel syndrome (IBS), there was marked heterogeneity of the gut microbiota, but no distinct ‘signature’ was evident. However

    更新日期:2020-03-05
  • Substantial and sustained improvement of serrated polyp detection after a simple educational intervention: results from a prospective controlled trial
    Gut (IF 17.943) Pub Date : 2020-03-05
    Arne G C Bleijenberg; Monique E van Leerdam; Marloes Bargeman; Jan Jacob Koornstra; Yasmijn J van Herwaarden; Manon CW Spaander; Silvia Sanduleanu; Barbara A J Bastiaansen; Erik J Schoon; Niels van Lelyveld; Evelien Dekker; Joep E G IJspeert

    Objective Serrated polyps (SPs) are an important cause of postcolonoscopy colorectal cancers (PCCRCs), which is likely the result of suboptimal SP detection during colonoscopy. We assessed the long-term effect of a simple educational intervention focusing on optimising SP detection. Design An educational intervention, consisting of two 45 min training sessions (held 3 years apart) on serrated polyp

    更新日期:2020-03-05
  • Cirrhosis as new indication for statins
    Gut (IF 17.943) Pub Date : 2020-03-05
    Jaime Bosch; Jordi Gracia-Sancho; Juan G Abraldes

    In the recent years, there have been an increasing number of reports on favourable effects of statins in patients with advanced chronic liver disease. These include reduction in portal pressure, improved liver sinusoidal endothelial and hepatic microvascular dysfunction, decreased fibrogenesis, protection against ischaemia/reperfusion injury, safe prolongation of ex vivo liver graft preservation, reduced

    更新日期:2020-03-05
  • Transjugular intrahepatic portosystemic stent-shunt in the management of portal hypertension.
    Gut (IF 17.943) Pub Date : 2020-02-29
    Dhiraj Tripathi,Adrian J Stanley,Peter C Hayes,Simon Travis,Matthew J Armstrong,Emmanuel A Tsochatzis,Ian A Rowe,Nicholas Roslund,Hamish Ireland,Mandy Lomax,Joanne A Leithead,Homoyon Mehrzad,Richard J Aspinall,Joanne McDonagh,David Patch

    These guidelines on transjugular intrahepatic portosystemic stent-shunt (TIPSS) in the management of portal hypertension have been commissioned by the Clinical Services and Standards Committee (CSSC) of the British Society of Gastroenterology (BSG) under the auspices of the Liver Section of the BSG. The guidelines are new and have been produced in collaboration with the British Society of Interventional

    更新日期:2020-03-02
  • Efficient acute and chronic infection of stem cell-derived hepatocytes by hepatitis C virus.
    Gut (IF 17.943) Pub Date : 2020-02-29
    Arnaud Carpentier,Julie Sheldon,Florian W R Vondran,Richard Jp Brown,Thomas Pietschmann

    OBJECTIVE AND DESIGN Human stem cell-derived hepatocyte-like cells (HLCs) have shown high potential as authentic model for dissection of the HCV life cycle and virus-induced pathogenesis. However, modest HCV replication, possibly due to robust innate immune responses, limits their broader use. To overcome these limitations and to dissect the mechanisms responsible for control of HCV, we analysed expression

    更新日期:2020-03-02
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