当前期刊: "检验"类期刊
显示样式:        排序: IF: - GO 导出
我的关注
我的收藏
您暂时未登录!
登录
  • Real-time volumetric MR thermometry using 3D echo-shifted sequence under an open source reconstruction platform
    Magn. Reson. Imaging (IF 2.112) Pub Date : 2020-04-04
    Rui Jiang; Sen Jia; Yangzi Qiao; Qiaoyan Chen; Jianhong Wen; Dong Liang; Xin Liu; Hairong Zheng; Chao Zou

    Purpose The aim of this work is to implement real-time 3D MR thermometry for high intensity focused ultrasound (HIFU) monitoring. Methods Volumetric MR thermometry was implemented based on a 3D echo-shifted sequence with short TR to improve temperature sensitivity. The 3D acquisition was accelerated in two phase encoding directions with controlled aliasing in volumetric parallel imaging (CAIPIRINHA)

    更新日期:2020-04-06
  • Performance of eight‐color dry antibody reagent in the detection of minimal residual disease in chronic lymphocytic leukemia samples
    Cytom. Part B Clin. Cytom. (IF 2.938) Pub Date : 2020-04-06
    Laiz Bento; Rodolfo Correia; Flávia de Sousa; Andressa Vaz; Eduardo Pedro; Daniela Schimidell; Nadila Millan; Marilia Passaro; Rodrigo Barroso; Nydia Bacal

    Minimal residual disease (MRD) in chronic lymphocytic leukemia (CLL) has prognostic and predictive significance. One of the approaches to detect MRD by flow cytometry (FC) is the use of dry antibody reagents such as DuraClone® RE CLB (Beckman Coulter—BC). The aim of this study was to evaluate the performance of the DuraClone® RE CLB in detecting MRD in CLL compared to liquid reagents.

    更新日期:2020-04-06
  • Optimized truncation to integrate multi‐channel MRS data using rank‐R singular value decomposition
    NMR Biomed. (IF 3.414) Pub Date : 2020-04-06
    Dongsuk Sung; Benjamin B. Risk; Maame Owusu‐Ansah; Xiaodong Zhong; Hui Mao; Candace C. Fleischer
    更新日期:2020-04-06
  • Judith James honored with the 2020 Stanley J. Korsmeyer Award
    J. Clin. Invest. (IF 12.282) Pub Date : 2020-04-01
    Sarah Jackson

    The American Society for Clinical Investigation has selected renowned lupus researcher and rheumatologist Judith James for the 2020 Stanley J. Korsmeyer Award, which is given annually in recognition of scientific excellence and outstanding mentorship of future researchers. Dr. James, member and chair of the Oklahoma Medical Research Foundation and Professor of Medicine at the University of Oklahoma

    更新日期:2020-04-03
  • The convalescent sera option for containing COVID-19
    J. Clin. Invest. (IF 12.282) Pub Date : 2020-03-13
    Arturo Casadevall; Liise-anne Pirofski

    As of early 2020, humanity is confronting a pandemic in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). SARS-CoV-2 causes coronavirus disease, abbreviated as COVID-19. At the time of this writing, SARS-CoV-2 is spreading in multiple countries, threatening a pandemic that will affect billions of people. This virus appears to be a new human pathogen. Currently there are no vaccines, monoclonal

    更新日期:2020-04-03
  • Alternative therapies in academic medical centers compromise evidence-based patient care
    J. Clin. Invest. (IF 12.282) Pub Date : 2020-03-16
    Donald M. Marcus

    During the past 20 years, integrative medicine centers that promote the use of alternative therapies were established in more than 70 medical and nursing schools. A survey of hospital websites and interviews with physicians, hospital administrators, and staff revealed that 15 research-intensive medical schools in the United States provide alternative therapies in their integrative medicine centers

    更新日期:2020-04-03
  • Immune escape and immunotherapy of acute myeloid leukemia
    J. Clin. Invest. (IF 12.282) Pub Date : 2020-04-01
    Luca Vago; Ivana Gojo

    In spite of the recent approval of new promising targeted therapies, the clinical outcome of patients with acute myeloid leukemia (AML) remains suboptimal, prompting the search for additional and synergistic therapeutic rationales. It is increasingly evident that the bone marrow immune environment of AML patients is profoundly altered, contributing to the severity of the disease but also providing

    更新日期:2020-04-03
  • Immunotherapy of multiple myeloma
    J. Clin. Invest. (IF 12.282) Pub Date : 2020-03-09
    Simone A. Minnie; Geoffrey R. Hill

    Multiple myeloma (MM), a bone marrow–resident hematological malignancy of plasma cells, has remained largely incurable despite dramatic improvements in patient outcomes in the era of myeloma-targeted and immunomodulatory agents. It has recently become clear that T cells from MM patients are able to recognize and eliminate myeloma, although this is subverted in the majority of patients who eventually

    更新日期:2020-04-03
  • Immunotherapy of lymphomas.
    J. Clin. Invest. (IF 12.282) Pub Date : 2020-02-10
    Stephen M Ansell,Yi Lin

    Lymphoid malignancies typically promote an infiltrate of immune cells at sites involved by the disease. While some of the immune cells present in lymphoma have effector function, the immune system is unable to eradicate the malignant clone. Therapies that optimize immune function therefore have the potential to improve the outcome of lymphoma patients. In this Review, we discuss immunologic approaches

    更新日期:2020-04-03
  • State of the art in CAR T cell therapy for CD19+ B cell malignancies
    J. Clin. Invest. (IF 12.282) Pub Date : 2020-04-01
    Matthew J. Frigault; Marcela V. Maus

    Cellular therapy for hematologic malignancies is a rapidly evolving field, with new iterations of novel constructs being developed at a rapid pace. Since the initial reports of chimeric antigen receptor T cell (CAR T cell)success in CD19+ B cell malignancies, multiple clinical trials of CAR T cell therapy directed to CD19 have led to the approval of this therapy by the FDA and the European Medicines

    更新日期:2020-04-03
  • Personal tumor antigens in blood malignancies: genomics-directed identification and targeting.
    J. Clin. Invest. (IF 12.282) Pub Date : 2020-01-27
    Livius Penter,Catherine J Wu

    Hematological malignancies have long been at the forefront of the development of novel immune-based treatment strategies. The earliest successful efforts originated from the extensive body of work in the field of allogeneic hematopoietic stem cell transplantation. These efforts laid the foundation for the recent exciting era of cancer immunotherapy, which includes immune checkpoint blockade, personal

    更新日期:2020-04-03
  • A role for connexin-43 in Duchenne muscular dystrophy cardiomyopathy.
    J. Clin. Invest. (IF 12.282) Pub Date : 2020-02-24
    Robin M Shaw,Jeffrey E Saffitz

    The cardiomyopathy of Duchenne muscular dystrophy (DMD) is an important cause of morbidity and mortality in affected males with this dreaded muscle disease. Previous studies have implicated changes in expression and subcellular localization of connexin-43 (Cx43), the major ventricular gap junction protein, in DMD cardiomyopathy. In this issue of the JCI, Himelman et al. explore how hypophosphorylation

    更新日期:2020-04-03
  • The gift of a lifetime: analysis of HIV at autopsy.
    J. Clin. Invest. (IF 12.282) Pub Date : 2020-02-24
    Frank Maldarelli

    Currently, the incidence of HIV infection exceeds the death rate from HIV, and as a result, the prevalence of individuals living with the infection continues to increase. A critical limitation preventing the development of curative strategies is the lack of knowledge regarding mechanisms that allow HIV-infected cells to persist in individuals during combination antiviral therapy (ART). In this issue

    更新日期:2020-04-03
  • The microbiome adds to the complexity of parathyroid hormone action on bone.
    J. Clin. Invest. (IF 12.282) Pub Date : 2020-03-03
    Sundeep Khosla

    Parathyroid hormone (PTH) has complex effects on bone, including stimulating bone formation and regulating the hematopoietic stem cell (HSC) niche. In the current issue of the JCI, Li et al. demonstrated that the microbiome, through the production of short-chain fatty acids and in particular, butyrate, is necessary for the ability of PTH to increase osteoblast numbers and stimulate bone formation.

    更新日期:2020-04-03
  • CoRESTed development of regulatory T cells.
    J. Clin. Invest. (IF 12.282) Pub Date : 2020-03-03
    Luisa Morales-Nebreda,Kathryn A Helmin,Benjamin D Singer

    Tregs require specific epigenetic signatures to induce and maintain their suppressive function in the context of inflammation and cancer surveillance. In this issue of the JCI, Xiong and colleagues identify a critical role for the epigenetic repressor REST corepressor 1 (CoREST) in promoting Treg suppressive transcriptional and functional programs. Pharmacologic inhibition and genetic loss of CoREST

    更新日期:2020-04-03
  • Intrinsic antiviral immunity drives neurodegeneration in Alzheimer disease
    J. Clin. Invest. (IF 12.282) Pub Date : 2020-03-09
    Stefano Pluchino; Cory Willis

    β-Amyloid aggregates found in brain plaques are viewed as triggers of cytotoxicity and neuroinflammation in Alzheimer disease (AD). However, the main β-amyloid (Aβ) species and what imbues the aggregates with such toxic potential are still not yet understood. In this issue of the JCI, Roy et al. show that Aβ complexed with nucleic acids triggers an antiviral type I interferon response in neuroglia

    更新日期:2020-04-03
  • One-two punch injury to tolerance mechanisms in graft-versus-host disease
    J. Clin. Invest. (IF 12.282) Pub Date : 2020-03-09
    Léolène J. Carrington; Ivan Maillard

    Chronic graft-versus-host disease (GVHD) is a major complication of allogeneic hematopoietic cell transplantation that resembles autoimmunity, with unclear pathogenesis and few effective therapeutic options. In this issue of the JCI, Dertschnig et al. used mouse models to investigate the basis of T cell autoreactivity following GVHD. Notably, GVHD caused irreversible damage to a population of tolerogenic

    更新日期:2020-04-03
  • c-Maf: a bad influence in the education of macrophages
    J. Clin. Invest. (IF 12.282) Pub Date : 2020-03-16
    Jose R. Conejo-Garcia; Paulo C. Rodriguez

    Tumor-associated macrophages (TAMs) represent the most abundant hematopoietic cell type in the solid tumor microenvironment. TAMs drive T cell inhibition, promote angiogenesis, and produce tumor growth factors. Although they can paradoxically exert antitumor activity and prime protective immunity, the pathways driving this phenotype remain unclear. In this issue of the JCI, Liu and colleagues identified

    更新日期:2020-04-03
  • Platelets: inflammatory effector cells in the conflagration of cystic fibrosis lung disease
    J. Clin. Invest. (IF 12.282) Pub Date : 2020-03-16
    Guy A. Zimmerman

    Cystic fibrosis (CF) is a multisystem disorder, but progressive inflammatory lung disease causes the greatest burden of morbidity and death. Recent translational and mechanistic studies of samples from patients, and observations in animal models, indicate that platelets may drive lung injury and contribute to dysregulated host defense in CF lung disease. In this issue of the JCI, Ortiz-Muñoz and Yu

    更新日期:2020-04-03
  • HPV16 drives cancer immune escape via NLRX1-mediated degradation of STING
    J. Clin. Invest. (IF 12.282) Pub Date : 2019-12-24
    Xiaobo Luo; Christopher R. Donnelly; Wang Gong; Blake R. Heath; Yuning Hao; Lorenza A. Donnelly; Toktam Moghbeli; Yee Sun Tan; Xin Lin; Emily Bellile; Benjamin A. Kansy; Thomas E. Carey; J. Chad Brenner; Lei Cheng; Peter J. Polverini; Meredith A. Morgan; Haitao Wen; Mark E. Prince; Robert L. Ferris; Yuying Xie; Simon Young; Gregory T. Wolf; Qianming Chen; Yu L. Lei

    The incidence of human papillomavirus–positive (HPV+) head and neck squamous cell carcinoma (HNSCC) has surpassed that of cervical cancer and is projected to increase rapidly until 2060. The coevolution of HPV with transforming epithelial cells leads to the shutdown of host immune detection. Targeting proximal viral nucleic acid–sensing machinery is an evolutionarily conserved strategy among viruses

    更新日期:2020-04-03
  • Circulating tumor DNA profile recognizes transformation to castration-resistant neuroendocrine prostate cancer.
    J. Clin. Invest. (IF 12.282) Pub Date : 2020-02-24
    Himisha Beltran,Alessandro Romanel,Vincenza Conteduca,Nicola Casiraghi,Michael Sigouros,Gian Marco Franceschini,Francesco Orlando,Tarcisio Fedrizzi,Sheng-Yu Ku,Emma Dann,Alicia Alonso,Juan Miguel Mosquera,Andrea Sboner,Jenny Xiang,Olivier Elemento,David M Nanus,Scott T Tagawa,Matteo Benelli,Francesca Demichelis

    Loss of androgen receptor (AR) signaling dependence occurs in approximately 15%-20% of advanced treatment-resistant prostate cancers, and this may manifest clinically as transformation from a prostate adenocarcinoma histology to a castration-resistant neuroendocrine prostate cancer (CRPC-NE). The diagnosis of CRPC-NE currently relies on a metastatic tumor biopsy, which is invasive for patients and

    更新日期:2020-04-03
  • Distinct interferon signatures and cytokine patterns define additional systemic autoinflammatory diseases
    J. Clin. Invest. (IF 12.282) Pub Date : 2019-12-24
    Adriana A. de Jesus; Yangfeng Hou; Stephen Brooks; Louise Malle; Angelique Biancotto; Yan Huang; Katherine R. Calvo; Bernadette Marrero; Susan Moir; Andrew J. Oler; Zuoming Deng; Gina A. Montealegre Sanchez; Amina Ahmed; Eric Allenspach; Bita Arabshahi; Edward Behrens; Susanne Benseler; Liliana Bezrodnik; Sharon Bout-Tabaku; AnneMarie C. Brescia; Diane Brown; Jon M. Burnham; Maria Soledad Caldirola;

    BACKGROUND. Undifferentiated systemic autoinflammatory diseases (USAIDs) present diagnostic and therapeutic challenges. Chronic interferon (IFN) signaling and cytokine dysregulation may identify diseases with available targeted treatments.

    更新日期:2020-04-03
  • Protein arginine methyltransferase 5 promotes cholesterol biosynthesis-mediated Th17 responses and autoimmunity.
    J. Clin. Invest. (IF 12.282) Pub Date : 2020-02-24
    Lindsay M Webb,Shouvonik Sengupta,Claudia Edell,Zayda L Piedra-Quintero,Stephanie A Amici,Janiret Narvaez Miranda,Makenzie Bevins,Austin Kennemer,Georgios Laliotis,Philip N Tsichlis,Mireia Guerau-de-Arellano

    Protein arginine methyltransferase 5 (PRMT5) catalyzes symmetric dimethylation (SDM) of arginine, a posttranslational modification involved in oncogenesis and embryonic development. However, the role and mechanisms by which PRMT5 modulates Th cell polarization and autoimmune disease have not yet been elucidated. Here, we found that PRMT5 promoted SREBP1 SDM and the induction of cholesterol biosynthetic

    更新日期:2020-04-03
  • HIV persists throughout deep tissues with repopulation from multiple anatomical sources
    J. Clin. Invest. (IF 12.282) Pub Date : 2020-01-07
    Antoine Chaillon; Sara Gianella; Simon Dellicour; Stephen A. Rawlings; Timothy E. Schlub; Michelli Faria De Oliveira; Caroline Ignacio; Magali Porrachia; Bram Vrancken; Davey M. Smith

    BACKGROUND. Understanding HIV dynamics across the human body is important for cure efforts. This goal has been hampered by technical difficulties and the challenge of obtaining fresh tissues.

    更新日期:2020-04-03
  • Prevention of connexin-43 remodeling protects against Duchenne muscular dystrophy cardiomyopathy
    J. Clin. Invest. (IF 12.282) Pub Date : 2020-01-07
    Eric Himelman; Mauricio A. Lillo; Julie Nouet; J. Patrick Gonzalez; Qingshi Zhao; Lai-Hua Xie; Hong Li; Tong Liu; Xander H.T. Wehrens; Paul D. Lampe; Glenn I. Fishman; Natalia Shirokova; Jorge E. Contreras; Diego Fraidenraich

    Aberrant expression of the cardiac gap junction protein connexin-43 (Cx43) has been suggested as playing a role in the development of cardiac disease in the mdx mouse model of Duchenne muscular dystrophy (DMD); however, a mechanistic understanding of this association is lacking. Here, we identified a reduction of phosphorylation of Cx43 serines S325/S328/S330 in human and mouse DMD hearts. We hypothesized

    更新日期:2020-04-03
  • An endocannabinoid-regulated basolateral amygdala–nucleus accumbens circuit modulates sociability
    J. Clin. Invest. (IF 12.282) Pub Date : 2019-12-24
    Oakleigh M. Folkes; Rita Báldi; Veronika Kondev; David J. Marcus; Nolan D. Hartley; Brandon D. Turner; Jade K. Ayers; Jordan J. Baechle; Maya P. Misra; Megan Altemus; Carrie A. Grueter; Brad A. Grueter; Sachin Patel

    Deficits in social interaction (SI) are a core symptom of autism spectrum disorders (ASDs); however, treatments for social deficits are notably lacking. Elucidating brain circuits and neuromodulatory signaling systems that regulate sociability could facilitate a deeper understanding of ASD pathophysiology and reveal novel treatments for ASDs. Here we found that in vivo optogenetic activation of the

    更新日期:2020-04-03
  • Genomics of lethal prostate cancer at diagnosis and castration resistance
    J. Clin. Invest. (IF 12.282) Pub Date : 2019-12-24
    Joaquin Mateo; George Seed; Claudia Bertan; Pasquale Rescigno; David Dolling; Ines Figueiredo; Susana Miranda; Daniel Nava Rodrigues; Bora Gurel; Matthew Clarke; Mark Atkin; Rob Chandler; Carlo Messina; Semini Sumanasuriya; Diletta Bianchini; Maialen Barrero; Antonella Petermolo; Zafeiris Zafeiriou; Mariane Fontes; Raquel Perez-Lopez; Nina Tunariu; Ben Fulton; Robert Jones; Ursula McGovern; Christy

    The genomics of primary prostate cancer differ from those of metastatic castration-resistant prostate cancer (mCRPC). We studied genomic aberrations in primary prostate cancer biopsies from patients who developed mCRPC, also studying matching, same-patient, diagnostic, and mCRPC biopsies following treatment. We profiled 470 treatment-naive prostate cancer diagnostic biopsies and, for 61 cases, mCRPC

    更新日期:2020-04-03
  • Suppression of the SLC7A11/glutathione axis causes synthetic lethality in KRAS-mutant lung adenocarcinoma
    J. Clin. Invest. (IF 12.282) Pub Date : 2019-12-24
    Kewen Hu; Kun Li; Jing Lv; Jie Feng; Jing Chen; Haigang Wu; Feixiong Cheng; Wenhao Jiang; Jieqiong Wang; Haixiang Pei; Paul J. Chiao; Zhenyu Cai; Yihua Chen; Mingyao Liu; Xiufeng Pang

    Oncogenic KRAS is a major driver in lung adenocarcinoma (LUAD) that has yet to be therapeutically conquered. Here we report that the SLC7A11/glutathione axis displays metabolic synthetic lethality with oncogenic KRAS. Through metabolomics approaches, we found that mutationally activated KRAS strikingly increased intracellular cystine levels and glutathione biosynthesis. SLC7A11, a cystine/glutamate

    更新日期:2020-04-03
  • Parathyroid hormone-dependent bone formation requires butyrate production by intestinal microbiota.
    J. Clin. Invest. (IF 12.282) Pub Date : 2020-01-09
    Jau-Yi Li,Mingcan Yu,Subhashis Pal,Abdul Malik Tyagi,Hamid Dar,Jonathan Adams,M Neale Weitzmann,Rheinallt M Jones,Roberto Pacifici

    Parathyroid hormone (PTH) is a critical regulator of skeletal development that promotes both bone formation and bone resorption. Using microbiota depletion by wide-spectrum antibiotics and germ-free (GF) female mice, we showed that the microbiota was required for PTH to stimulate bone formation and increase bone mass. Microbiota depletion lowered butyrate levels, a metabolite responsible for gut-bone

    更新日期:2020-04-03
  • Small molecule JQ1 promotes prostate cancer invasion via BET-independent inactivation of FOXA1
    J. Clin. Invest. (IF 12.282) Pub Date : 2019-12-24
    Leiming Wang; Mafei Xu; Chung-Yang Kao; Sophia Y. Tsai; Ming-Jer Tsai

    Recent findings have shown that inhibitors targeting bromodomain and extraterminal domain (BET) proteins, such as the small molecule JQ1, are potent growth inhibitors of many cancers and hold promise for cancer therapy. However, some reports have also revealed that JQ1 can activate additional oncogenic pathways and may affect epithelial-to-mesenchymal transition (EMT). Therefore, it is important to

    更新日期:2020-04-03
  • Bruton tyrosine kinase deficiency augments NLRP3 inflammasome activation and causes IL-1β–mediated colitis
    J. Clin. Invest. (IF 12.282) Pub Date : 2020-01-02
    Liming Mao; Atsushi Kitani; Eitaro Hiejima; Kim Montgomery-Recht; Wenchang Zhou; Ivan Fuss; Adrian Wiestner; Warren Strober

    Bruton tyrosine kinase (BTK) is present in a wide variety of cells and may thus have important non–B cell functions. Here, we explored the function of this kinase in macrophages with studies of its regulation of the NLR family, pyrin domain–containing 3 (NLRP3) inflammasome. We found that bone marrow–derived macrophages (BMDMs) from BTK-deficient mice or monocytes from patients with X-linked agammaglobulinemia

    更新日期:2020-04-03
  • Capsular glycan recognition provides antibody-mediated immunity against tuberculosis.
    J. Clin. Invest. (IF 12.282) Pub Date : 2020-01-14
    Tingting Chen,Caroline Blanc,Yanyan Liu,Elise Ishida,Sarah Singer,Jiayong Xu,Maju Joe,Elizabeth R Jenny-Avital,John Chan,Todd L Lowary,Jacqueline M Achkar

    A better understanding of all immune components involved in protecting against Mycobacterium tuberculosis infection is urgently needed to inform strategies for novel immunotherapy and tuberculosis (TB) vaccine development. Although cell-mediated immunity is critical, increasing evidence supports that antibodies also have a protective role against TB. Yet knowledge of protective antigens is limited

    更新日期:2020-04-03
  • Ubiquitous antigen-specific T regulatory type 1 cells variably suppress hepatic and extrahepatic autoimmunity.
    J. Clin. Invest. (IF 12.282) Pub Date : 2020-03-03
    Channakeshava Sokke Umeshappa,Jacques Mbongue,Santiswarup Singha,Saswat Mohapatra,Jun Yamanouchi,Justin A Lee,Roopa Hebbandi Nanjundappa,Kun Shao,Urs Christen,Yang Yang,Kristofor K Ellestad,Pere Santamaria

    Peptide MHC class II-based (pMHCII-based) nanomedicines trigger the formation of multicellular regulatory networks by reprogramming autoantigen-experienced CD4+ T cells into autoimmune disease-suppressing T regulatory type 1 (TR1) cells. We have shown that pMHCII-based nanomedicines displaying liver autoimmune disease-relevant yet ubiquitously expressed antigens can blunt various liver autoimmune disorders

    更新日期:2020-04-03
  • Inhibiting the coregulator CoREST impairs Foxp3+ Treg function and promotes antitumor immunity.
    J. Clin. Invest. (IF 12.282) Pub Date : 2020-01-09
    Yan Xiong,Liqing Wang,Eros Di Giorgio,Tatiana Akimova,Ulf H Beier,Rongxiang Han,Matteo Trevisanut,Jay H Kalin,Philip A Cole,Wayne W Hancock

    Foxp3+ Tregs are key to immune homeostasis, but the contributions of various large, multiprotein complexes that regulate gene expression remain unexplored. We analyzed the role in Tregs of the evolutionarily conserved CoREST complex, consisting of a scaffolding protein, Rcor1 or Rcor2, plus Hdac1 or Hdac2 and Lsd1 enzymes. Rcor1, Rcor2, and Lsd1 were physically associated with Foxp3, and mice with

    更新日期:2020-04-03
  • Enasidenib drives human erythroid differentiation independently of isocitrate dehydrogenase 2
    J. Clin. Invest. (IF 12.282) Pub Date : 2020-01-02
    Ritika Dutta; Tian Yi Zhang; Thomas Köhnke; Daniel Thomas; Miles Linde; Eric Gars; Melissa Stafford; Satinder Kaur; Yusuke Nakauchi; Raymond Yin; Armon Azizi; Anupama Narla; Ravindra Majeti

    Cancer-related anemia is present in more than 60% of newly diagnosed cancer patients and is associated with substantial morbidity and high medical costs. Drugs that enhance erythropoiesis are urgently required to decrease transfusion rates and improve quality of life. Clinical studies have observed an unexpected improvement in hemoglobin and RBC transfusion-independence in patients with acute myeloid

    更新日期:2020-04-03
  • High residual C-peptide likely contributes to glycemic control in type 1 diabetes
    J. Clin. Invest. (IF 12.282) Pub Date : 2020-01-02
    Michael R. Rickels; Carmella Evans-Molina; Henry T. Bahnson; Alyssa Ylescupidez; Kristen J. Nadeau; Wei Hao; Mark A. Clements; Jennifer L. Sherr; Richard E. Pratley; Tamara S. Hannon; Viral N. Shah; Kellee M. Miller; Carla J. Greenbaum; the T1D Exchange β-Cell Function Study Group

    BACKGROUND. Residual C-peptide is detected in many people for years following the diagnosis of type 1 diabetes; however, the physiologic significance of low levels of detectable C-peptide is not known.

    更新日期:2020-04-03
  • TYK2 inhibition reduces type 3 immunity and modifies disease progression in murine spondyloarthritis
    J. Clin. Invest. (IF 12.282) Pub Date : 2020-03-09
    Eric Gracey; Dominika Hromadová; Melissa Lim; Zoya Qaiyum; Michael Zeng; Yuchen Yao; Archita Srinath; Yuriy Baglaenko; Natalia Yeremenko; William Westlin; Craig Masse; Mathias Müller; Birgit Strobl; Wenyan Miao; Robert D. Inman

    Spondyloarthritis (SpA) represents a family of inflammatory diseases of the spine and peripheral joints. Ankylosing spondylitis (AS) is the prototypic form of SpA in which progressive disease can lead to fusion of the spine. Therapeutically, knowledge of type 3 immunity has translated into the development of IL-23– and IL-17A–blocking antibodies for the treatment of SpA. Despite being able to provide

    更新日期:2020-04-03
  • The Mir181ab1 cluster promotes KRAS-driven oncogenesis and progression in lung and pancreas
    J. Clin. Invest. (IF 12.282) Pub Date : 2019-12-24
    Karmele Valencia; Oihane Erice; Kaja Kostyrko; Simone Hausmann; Elizabeth Guruceaga; Anuradha Tathireddy; Natasha M. Flores; Leanne C. Sayles; Alex G. Lee; Rita Fragoso; Tian-Qiang Sun; Adrian Vallejo; Marta Roman; Rodrigo Entrialgo-Cadierno; Itziar Migueliz; Nerea Razquin; Puri Fortes; Fernando Lecanda; Jun Lu; Mariano Ponz-Sarvise; Chang-Zheng Chen; Pawel K. Mazur; E. Alejandro Sweet-Cordero; Silvestre

    Few therapies are currently available for patients with KRAS-driven cancers, highlighting the need to identify new molecular targets that modulate central downstream effector pathways. Here we found that the microRNA (miRNA) cluster including miR181ab1 is a key modulator of KRAS-driven oncogenesis. Ablation of Mir181ab1 in genetically engineered mouse models of Kras-driven lung and pancreatic cancer

    更新日期:2020-04-03
  • Graft-versus-host disease reduces lymph node display of tissue-restricted self-antigens and promotes autoimmunity.
    J. Clin. Invest. (IF 12.282) Pub Date : 2020-01-09
    Simone Dertschnig,Pamela Evans,Pedro Santos E Sousa,Teresa Manzo,Ivana R Ferrer,Hans J Stauss,Clare L Bennett,Ronjon Chakraverty

    Acute graft-versus-host disease (GVHD) is initially triggered by alloreactive T cells, which damage peripheral tissues and lymphoid organs. Subsequent transition to chronic GVHD involves the emergence of autoimmunity although the underlying mechanisms driving this process are unclear. Here, we tested the hypothesis that acute GVHD blocks peripheral tolerance of autoreactive T cells by impairing lymph

    更新日期:2020-04-03
  • Type I interferon response drives neuroinflammation and synapse loss in Alzheimer disease.
    J. Clin. Invest. (IF 12.282) Pub Date : 2020-01-09
    Ethan R Roy,Baiping Wang,Ying-Wooi Wan,Gabriel S Chiu,Allysa L Cole,Zhuoran Yin,Nicholas E Propson,Yin Xu,Joanna L Jankowsky,Zhandong Liu,Virginia My Lee,John Q Trojanowski,Stephen D Ginsberg,Oleg Butovsky,Hui Zheng,Wei Cao

    Type I interferon (IFN) is a key cytokine that curbs viral infection and cell malignancy. Previously, we have demonstrated a potent IFN immunogenicity of nucleic acid (NA)-containing amyloid fibrils in the periphery. Here, we investigated whether IFN is associated with β-amyloidosis inside the brain and contributes to neuropathology. An IFN-stimulated gene (ISG) signature was detected in the brains

    更新日期:2020-04-03
  • Pancreatic triglyceride lipase mediates lipotoxic systemic inflammation.
    J. Clin. Invest. (IF 12.282) Pub Date : 2020-01-09
    Cristiane de Oliveira,Biswajit Khatua,Pawan Noel,Sergiy Kostenko,Arup Bag,Bijinu Balakrishnan,Krutika S Patel,Andre A Guerra,Melissa N Martinez,Shubham Trivedi,Ann E McCullough,Dora M Lam-Himlin,Sarah Navina,Douglas O Faigel,Norio Fukami,Rahul Pannala,Anna Evans Phillips,Georgios I Papachristou,Erin E Kershaw,Mark E Lowe,Vijay P Singh

    Visceral adipose tissue plays a critical role in numerous diseases. While imaging studies often show adipose involvement in abdominal diseases, their outcomes may vary from being a mild self limited illness to one with systemic inflammation and organ failure. We therefore compared the pattern of visceral adipose injury during acute pancreatitis and acute diverticulitis to determine its role in organ

    更新日期:2020-04-03
  • Claudin-2 deficiency associates with hypercalciuria in mice and human kidney stone disease
    J. Clin. Invest. (IF 12.282) Pub Date : 2020-03-09
    Joshua N. Curry; Matthew Saurette; Masomeh Askari; Lei Pei; Michael B. Filla; Megan R. Beggs; Peter S.N. Rowe; Timothy Fields; Andre J. Sommer; Chizu Tanikawa; Yoichiro Kamatani; Andrew P. Evan; Mehdi Totonchi; R. Todd Alexander; Koichi Matsuda; Alan S.L. Yu

    The major risk factor for kidney stone disease is idiopathic hypercalciuria. Recent evidence implicates a role for defective calcium reabsorption in the renal proximal tubule. We hypothesized that claudin-2, a paracellular cation channel protein, mediates proximal tubule calcium reabsorption. We found that claudin-2–null mice have hypercalciuria due to a primary defect in renal tubule calcium transport

    更新日期:2020-04-03
  • Visceral adipose NLRP3 impairs cognition in obesity via IL1R1 on Cx3cr1+ cells.
    J. Clin. Invest. (IF 12.282) Pub Date : 2020-01-14
    De-Huang Guo,Masaki Yamamoto,Caterina M Hernandez,Hesam Khodadadi,Babak Baban,Alexis M Stranahan

    Induction of the inflammasome protein cryopyrin (NLRP3) in visceral adipose tissue (VAT) promotes release of the pro-inflammatory cytokine interleukin-1β (IL1β) in obesity. While this mechanism contributes to peripheral metabolic dysfunction, effects on the brain remain unexplored. These studies investigated whether visceral adipose NLRP3 impairs cognition by activating microglial interleukin-1 receptor

    更新日期:2020-04-03
  • Angiopoietin-2 blockade ameliorates autoimmune neuroinflammation by inhibiting leukocyte recruitment into the CNS
    J. Clin. Invest. (IF 12.282) Pub Date : 2020-03-09
    Zhilin Li; Emilia A. Korhonen; Arianna Merlini; Judith Strauss; Eleonoora Wihuri; Harri Nurmi; Salli Antila; Jennifer Paech; Urban Deutsch; Britta Engelhardt; Sudhakar Chintharlapalli; Gou Young Koh; Alexander Flügel; Kari Alitalo

    Angiopoietin-2 (Ang2), a ligand of the endothelial Tie2 tyrosine kinase, is involved in vascular inflammation and leakage in critically ill patients. However, the role of Ang2 in demyelinating central nervous system (CNS) autoimmune diseases is unknown. Here, we report that Ang2 is critically involved in the pathogenesis of experimental autoimmune encephalomyelitis (EAE), a rodent model of multiple

    更新日期:2020-04-03
  • Genome-wide plasma DNA methylation features of metastatic prostate cancer
    J. Clin. Invest. (IF 12.282) Pub Date : 2020-03-09
    Anjui Wu; Paolo Cremaschi; Daniel Wetterskog; Vincenza Conteduca; Gian Marco Franceschini; Dimitrios Kleftogiannis; Anuradha Jayaram; Shahneen Sandhu; Stephen Q. Wong; Matteo Benelli; Samanta Salvi; Giorgia Gurioli; Andrew Feber; Mariana Buongermino Pereira; Anna Maria Wingate; Enrique Gonzalez-Billalebeitia; Ugo De Giorgi; Francesca Demichelis; Stefano Lise; Gerhardt Attard

    Tumor DNA circulates in the plasma of cancer patients admixed with DNA from noncancerous cells. The genomic landscape of plasma DNA has been characterized in metastatic castration-resistant prostate cancer (mCRPC) but the plasma methylome has not been extensively explored. Here, we performed next-generation sequencing (NGS) on plasma DNA with and without bisulfite treatment from mCRPC patients receiving

    更新日期:2020-04-03
  • Leptin mediates postprandial increases in body temperature through hypothalamus–adrenal medulla–adipose tissue crosstalk
    J. Clin. Invest. (IF 12.282) Pub Date : 2020-03-09
    Rachel J. Perry; Kun Lyu; Aviva Rabin-Court; Jianying Dong; Xiruo Li; Yunfan Yang; Hua Qing; Andrew Wang; Xiaoyong Yang; Gerald I. Shulman

    Meal ingestion increases body temperature in multiple species, an effect that is blunted by obesity. However, the mechanisms responsible for these phenomena remain incompletely understood. Here we show that refeeding increases plasma leptin concentrations approximately 8-fold in 48-hour-fasted lean rats, and this normalization of plasma leptin concentrations stimulates adrenomedullary catecholamine

    更新日期:2020-04-03
  • Targeting AML-associated FLT3 mutations with a type I kinase inhibitor
    J. Clin. Invest. (IF 12.282) Pub Date : 2020-03-09
    LaQuita M. Jones; Katelyn Melgar; Lyndsey Bolanos; Kathleen Hueneman; Morgan M. Walker; Jian-Kang Jiang; Kelli M. Wilson; Xiaohu Zhang; Jian Shen; Fan Jiang; Patrick Sutter; Amy Wang; Xin Xu; Gregory J. Tawa; Scott B. Hoyt; Mark Wunderlich; Eric O’Brien; John P. Perentesis; Daniel T. Starczynowski; Craig J. Thomas

    Tyrosine kinase domain (TKD) mutations contribute to acquired resistance to FMS-like tyrosine kinase 3 (FLT3) inhibitors used to treat FLT3-mutant acute myeloid leukemia (AML). We report a cocrystal structure of FLT3 with a type I inhibitor, NCGC1481, that retained potent binding and activity against FLT3 TKD and gatekeeper mutations. Relative to the current generation of advanced FLT3 inhibitors,

    更新日期:2020-04-03
  • Profilin1 delivery tunes cytoskeleton dynamics towards CNS axon regeneration.
    J. Clin. Invest. (IF 12.282) Pub Date : 2020-01-16
    Rita Pinto-Costa,Sara Castro Sousa,Sérgio C Leite,Joana Nogueira-Rodrigues,Tiago Ferreira da Silva,Diana Machado,Joana Beatriz Moreira Marques,Ana Catarina Costa,Márcia A Liz,Francesca Bartolini,Pedro Brites,Mercedes Costell,Reinhard Fässler,Monica M Sousa

    After trauma, regeneration of adult CNS axons is abortive causing devastating neurologic deficits. Despite progress in rehabilitative care, there is no effective treatment stimulating axon growth following injury. Using models with different regenerative capacities, followed by gain- and loss-of-function analysis, we identified profilin1 (Pfn1) as a coordinator of actin and microtubules (MTs), powering

    更新日期:2020-04-03
  • Cystic fibrosis transmembrane conductance regulator dysfunction in platelets drives lung hyperinflammation.
    J. Clin. Invest. (IF 12.282) Pub Date : 2020-01-21
    Guadalupe Ortiz-Munoz,Michelle A Yu,Emma Lefrançais,Benat Mallavia,Colin Valet,Jennifer J Tian,Serena Ranucci,Kristin M Wang,Zhe Liu,Nicholas Kwaan,Diana Dawson,Mary Ellen Kleinhenz,Fadi T Khasawneh,Peter M Haggie,Alan S Verkman,Mark R Looney

    Cystic fibrosis (CF) lung disease is characterized by an inflammatory response that can lead to terminal respiratory failure. The cystic fibrosis transmembrane regulator (CFTR) is mutated in CF and we hypothesized that dysfunctional CFTR in platelets, which are key participants in immune responses, is a central determinant of CF inflammation. We found that deletion of CFTR in platelets produced exaggerated

    更新日期:2020-04-03
  • Neogenin neutralization prevents photoreceptor loss in inherited retinal degeneration
    J. Clin. Invest. (IF 12.282) Pub Date : 2020-03-16
    Jason Charish; Alireza P. Shabanzadeh; Danian Chen; Patrick Mehlen; Santhosh Sethuramanujam; Hidekiyo Harada; Vera L. Bonilha; Gautam Awatramani; Rod Bremner; Philippe P. Monnier

    Inherited retinal degenerations (IRDs) are characterized by the progressive loss of photoreceptors and represent one of the most prevalent causes of blindness among working-age populations. Cyclic nucleotide dysregulation is a common pathological feature linked to numerous forms of IRD, yet the precise mechanisms through which this contributes to photoreceptor death remain elusive. Here we demonstrate

    更新日期:2020-04-03
  • Plasminogen as a prognostic biomarker for HBV-related acute-on-chronic liver failure
    J. Clin. Invest. (IF 12.282) Pub Date : 2020-03-16
    Daxian Wu; Sainan Zhang; Zhongyang Xie; Ermei Chen; Qunfang Rao; Xiaoli Liu; Kaizhou Huang; Jing Yang; Lanlan Xiao; Feiyang Ji; Zhengyi Jiang; Yalei Zhao; Xiaoxi Ouyang; Danhua Zhu; Xiahong Dai; Zhouhua Hou; Bingjie Liu; Binbin Deng; Ning Zhou; Hainv Gao; Zeyu Sun; Lanjuan Li

    BACKGROUND. HBV-related acute-on-chronic liver failure (HBV-ACLF) is hallmarked by high short-term mortality rates, calling for accurate prognostic biomarkers for initial risk stratification.

    更新日期:2020-04-03
  • Transcription factor c-Maf is a checkpoint that programs macrophages in lung cancer.
    J. Clin. Invest. (IF 12.282) Pub Date : 2020-01-16
    Min Liu,Zan Tong,Chuanlin Ding,Fengling Luo,Shouzhen Wu,Caijun Wu,Sabrin Albeituni,Liqing He,Xiaoling Hu,David Tieri,Eric C Rouchka,Michito Hamada,Satoru Takahashi,Andrew A Gibb,Goetz Kloecker,Huang-Ge Zhang,Michael Bousamra,Bradford G Hill,Xiang Zhang,Jun Yan

    Macrophages have been linked to tumor initiation, progression, metastasis and treatment resistance. However, the transcriptional regulation of macrophages driving the pro-tumor function remains elusive. Here, we demonstrate that the transcription factor c-Maf is a critical controller for immunosuppressive macrophage polarization and function in cancer. c-Maf controls many M2-related genes and has direct

    更新日期:2020-04-03
  • Steroid-resistance in Diamond Blackfan anemia associates with p57Kip2 dysregulation in erythroid progenitors.
    J. Clin. Invest. (IF 12.282) Pub Date : 2020-01-21
    Ryan J Ashley,Hongxia Yan,Nan Wang,John Hale,Brian M Dulmovits,Julien Papoin,Meagan E Olive,Namrata D Udeshi,Steven A Carr,Adrianna Vlachos,Jeffrey M Lipton,Lydie Da Costa,Christopher D Hillyer,Sandrina Kinet,Naomi Taylor,Narla Mohandas,Anupama Narla,Lionel Blanc

    Despite the effective clinical use of steroids for the treatment of Diamond Blackfan anemia (DBA), the mechanistic bases via which glucocorticoids regulate human erythropoiesis remain poorly understood. Here, we report that the sensitivity of erythroid differentiation to dexamethasone (Dex) is dependent on the developmental origin of human CD34+ progenitor cells, specifically increasing the expansion

    更新日期:2020-04-03
  • Gut epithelial TSC1/mTOR controls RIPK3-dependent necroptosis in intestinal inflammation and cancer.
    J. Clin. Invest. (IF 12.282) Pub Date : 2020-01-21
    Yadong Xie,Yifan Zhao,Lei Shi,Wei Li,Kun Chen,Min Li,Xia Chen,Haiwei Zhang,Tiantian Li,Matsuzawa-Ishimoto Yu,Xiaomin Yao,Dianhui Shao,Zunfu Ke,Jian Li,Yan Chen,Xiaoming Zhang,Jun Cui,Shuzhong Cui,Qibin Leng,Ken Cadwell,Xiaoxia Li,Hong Wei,Haibing Zhang,Huabin Li,Hui Xiao

    While the Western-diet and dysbiosis are the most prominent environmental factors associated with inflammatory bowel diseases (IBDs), the corresponding host factors and cellular mechanisms remain poorly defined. Here we report that the TSC1-mTOR pathway in the gut epithelium represents a metabolic and innate immune checkpoint for intestinal dysfunction and inflammation. mTOR hyperactivation triggered

    更新日期:2020-04-03
  • Epithelial splicing regulatory protein 2-mediated alternative splicing reprograms hepatocytes in severe alcoholic hepatitis.
    J. Clin. Invest. (IF 12.282) Pub Date : 2020-01-16
    Jeongeun Hyun,Zhaoli Sun,Ali Reza Ahmadi,Sushant Bangru,Ullas V Chembazhi,Kuo Du,Tianyi Chen,Hidekazu Tsukamoto,Ivan Rusyn,Auinash Kalsotra,Anna Mae Diehl

    Severe alcoholic hepatitis (SAH) is a deadly liver disease without an effective medical therapy. Although SAH mortality is known to correlate with hepatic accumulation of immature liver cells, why this occurs, and how it causes death is unclear. Here, we demonstrated that expression of epithelial splicing regulatory protein-2 (ESRP2), an RNA splicing factor that maintains the non-proliferative, mature

    更新日期:2020-04-03
  • 更新日期:2020-03-31
  • The independent indicators for differentiating renal cell carcinoma from renal angiomyolipoma by contrast-enhanced ultrasound
    BMC Med. Imaging (IF 1.622) Pub Date : 2020-03-30
    Hongli Cao; Liang Fang; Lin Chen; Jia Zhan; Xuehong Diao; Yingchun Liu; Chen Lu; Zhengwang Zhang; Yue Chen

    The value of contrast-enhanced ultrasound (CEUS) in differentiating between renal cell carcinoma (RCC) and angiomyolipoma (AML) was analyzed. The purpose of this study was to identify the independent indicators of CEUS for predicting RCC. A total of 172 renal tumors (150 RCCs, 22 AMLs) in 165 patients underwent conventional ultrasound (CUS) and CEUS examinations before radical or partial nephrectomy

    更新日期:2020-03-31
  • Feasibility of real‐time cardiac MRI in mice using tiny golden angle radial sparse
    NMR Biomed. (IF 3.414) Pub Date : 2020-03-29
    Hao Li; Patrick Metze; Alireza Abaei; Wolfgang Rottbauer; Steffen Just; Qinghua Lu; Volker Rasche
    更新日期:2020-03-30
  • Demonstration and suppression of respiration‐related artifacts in Bloch–Siegert shift‐based B1+ maps of the human brain
    NMR Biomed. (IF 3.414) Pub Date : 2020-03-26
    Omer F. Oran; L. Martyn Klassen; Hacene Serrai; Ravi S. Menon
    更新日期:2020-03-27
  • A comparison study of inhomogeneous magnetization transfer (ihMT) and magnetization transfer (MT) in multiple sclerosis based on whole brain acquisition at 3.0 T
    Magn. Reson. Imaging (IF 2.112) Pub Date : 2020-03-26
    Lei Zhang; Baohong Wen; Tao Chen; Hongzhe Tian; Hongqiang Xue; Huipeng Ren; Li Li; Qing Fan; Zhuanqin Ren

    Introduction Multiple sclerosis (MS) is a central nervous system disorder that may eventually affect its function. The clinical standard for MS severity is based on a clinical scale, which lacks lesion specific information. Magnetic resonance imaging of MS faces the challenge of myelin specificity, and in this work a new method inhomogeneous magnetization transfer (ihMT) is investigated as new biomarker

    更新日期:2020-03-27
Contents have been reproduced by permission of the publishers.
导出
全部期刊列表>>
宅家赢大奖
向世界展示您的会议墙报和演示文稿
全球疫情及响应:BMC Medicine专题征稿
新版X-MOL期刊搜索和高级搜索功能介绍
化学材料学全球高引用
ACS材料视界
x-mol收录
自然科研论文编辑服务
南方科技大学
南方科技大学
西湖大学
中国科学院长春应化所于聪-4-8
复旦大学
课题组网站
X-MOL
香港大学化学系刘俊治
中山大学化学工程与技术学院
试剂库存
天合科研
down
wechat
bug