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Continuous Monitoring for Atrial Fibrillation in Individuals at Increased Risk of Acute Exacerbations of COPD. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2025-02-07 David M MacDonald,Trent Fischer,Selcuk Adabag,Shakeel Amanullah,Jose Diaz,Philip Diaz,Ken M Kunisaki,Pamela L Lutsey,Christine H Wendt
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Mucoid Staphylococcus aureus - Prevalence and Association with Lung Function in People with Cystic Fibrosis. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2025-02-07 Christine H Rumpf,Timo Janssen,Robert Jonathan Hait,Karin Romme,Clemens Decker,Janne Peters,Corinna Czowalla,Susanne Deiwick,Dennis Görlich,Angelika Dübbers,Jörg Große-Onnebrink,Christina Kessler,Peter Küster,Holger Schültingkemper,Helge Hebestreit,Ute Graepler-Mainka,Silke van Koningsbruggen-Rietschel,Tom Schildberg,Sabine Renner,Susanne Nährig,Bettina Wollschläger,Anne Schlegtendal,Sivagurunathan
RATIONALE The mucoid phenotype of Staphylococcus aureus is caused by adaptation. Excessive biofilm formation associated with a protective effect for mucoid S. aureus was observed in isolates from respiratory samples of people with cystic fibrosis (pwCF). However, there is little knowledge about the prevalence of mucoid S. aureus in pwCF and a potential association with CF lung disease. METHODS A prospective
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Real-World Smoking History Documentation and Identification of Lung Cancer Screening Candidates. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2025-02-07 Kyle M Koster,Abigail Feinberg,Keith Sigel,Juan Wisnivesky,Cardinale Smith,Minal Kale
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Long-Term Fine Particulate Matter Exposure on Lung Cancer Incidence and Mortality in Chinese Nonsmokers. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2025-02-07 Meng Zhu,Yuting Han,Yuanlin Mou,Xia Meng,Chen Ji,Xia Zhu,Canqing Yu,Dianjianyi Sun,Ling Yang,Qiufen Sun,Yiping Chen,Huaidong Du,Juncheng Dai,Zhengming Chen,Zhibin Hu,Jun Lv,Guangfu Jin,Hongxia Ma,Haidong Kan,Liming Li,Hongbing Shen
Rationale: The association between fine particulate matter (PM2.5) and lung cancer incidence in non-smokers (LCINS) remains inconsistent. Objectives: To investigate the association between long-term PM2.5 exposure and LCINS in a Chinese population and to assess the modifying effect of genetic factors. Methods: Time-dependent Cox proportional hazard models were employed to evaluate the hazard ratios
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Charting a Path Toward Diagnostic Excellence and Equity in Thoracic Oncology: The Critical Role of Interventional and Onco-Pulmonologists. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2025-02-03 Roger Y Kim,Christopher M Kapp,Jeffrey Thiboutot,M Patricia Rivera,A Christine Argento
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Sleep Problems in Sickle Cell Disease. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2025-02-01 Krista Reiling,Sonal Malhotra
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C-reactive Protein for TB Triage Testing Is Not the Answer for Some Populations-Did We Ask the Right Question? Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2025-01-29 Adrienne E Shapiro,Ronit R Dalmat
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Moving Away from Segregated Lung Function Equations: Effects of Transitioning to Race-neutral References in Children. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2025-01-29 Nadia L Krupp,Erick Forno
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Echocardiographic Endophenotypes of Chronic Obstructive Pulmonary Disease: A Step Towards Personalized Medicine. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2025-01-29 Benjamin H Freed,Thenappan Thenappan
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Reply to Hua et al.: The Driving Pressure Setting of ARDS: Beyond the Age. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2025-01-23 Eleni Papoutsi,Ilias I Siempos
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The Driving Pressure Setting of ARDS: Beyond the Age. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2025-01-23 Zi Xuan Hua,Hong Peng Li,Xin Xin Ran,Qing Yun Li
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Effect of Normobaric Hypoxia on Invasive Exercise Hemodynamics in Patients with Pulmonary Vascular Disease: A Randomized Controlled Trial. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2025-01-23 Mona Lichtblau,Simon R Schneider,Julian Müller,Meret Bauer,Arcangelo F Carta,Laura Mayer,Esther I Schwarz,Michael Furian,Stéphanie Saxer,Silvia Ulrich
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Navigating the Nuances Around Extubation Decisions and Observational Evidence. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2025-01-23 Craig A Willamson,Andrew J Admon
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Decoding Sepsis Globally: Towards Precision Medicine Through Clustering in Sub-Saharan Africa. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2025-01-23 Aleksandra Leligdowicz,W Joost Wiersinga
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Nasal High Flow to Modulate Dyspnea in Orally Intubated Weanable Patients. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2025-01-23 Lara Pisani,Massimo Antonelli
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Unlocking the Therapeutic Code of Mesenchymal Stromal Cells. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2025-01-23 Krithika Lingappan,Michael A Matthay
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Bone-Specific Manifestations of Spondylothoracic Dysostosis in Jarcho-Levin Syndrome. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2025-01-21 Huajian Shan,Peixin Liu,Xiao Wang
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Reply to Shan et al.: Bone-Specific Manifestations of Spondylothoracic Dysostosis in Jarcho-Levin Syndrome. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2025-01-21 Wilfredo De Jesús-Rojas,Alberto Santiago Cornier
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Insights into Pulmonary Heart Disease at High Altitude: Hypoxia and PM2.5 Interactions. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2025-01-21 Ya Xiao,Runxue Ma,Ce Liu,Huanhuan Wei,Baofeng Zhou,Chunyan Gui,Bo Yang,Yunshan Cao,Kai Zhang,Bin Luo
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Stop the Asthma Treatment Elevator, We Need to Get Off! Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2025-01-21 Andy Bush,Ian D Pavord
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Novel Therapies for Sleep Disorder Breathing. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2025-01-21 Gonzalo Labarca,Dana Saleh,Anunya Hiranrattana,Eric Heckman
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Dynamics of Subphenotypes in Critical Illness: When the Tick-Tock of the Clock Counts. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2025-01-21 Adrian Ceccato,Oscar Peñuelas,Antonio Artigas
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Location of Care Delivery for Pulmonary Arterial Hypertension in the United States. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2025-01-21 Peter J Leary,Rachel J Le,Sumeet Panjabi,John Hartney,Amit Goyal,Charlotte Ward,Dwaipayan Mukherjee,Nathan Hatton,Samuel G Rayner,Hayley D Germack,John J Ryan
RATIONALE Guidelines recommend patients with pulmonary arterial hypertension (PAH) be referred to pulmonary hypertension (PH) centers, but little is known about where care is actually delivered in the United States (US). OBJECTIVES To use prescription patterns to estimate the proportion of PAH care delivered at US PH centers and explore factors associated with location of care. METHODS This retrospective
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Early vs. Delayed Switching from Controlled to Assisted Ventilation: A Target Trial Emulation. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2025-01-21 Carmen A T Reep,Evert-Jan Wils,Lucas M Fleuren,Alexander Breskin,Giacomo Bellani,John G Laffey,Laurent Brochard,Tài Pham,Leo Heunks
RATIONALE In critically ill patients receiving invasive mechanical ventilation, switching from controlled to assisted ventilation is a crucial milestone towards ventilator liberation. The optimal timing for switching to assisted ventilation has not been studied. OBJECTIVES Our objective was to determine whether a strategy of early as compared to delayed switching affects the duration of invasive mechanical
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Is Achieving a Fully Race-Neutral Approach to Lung Function Classification Even Possible? Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2025-01-21 Amin Adibi,Mohsen Sadatsafavi,Emily P Brigham,Surya P Bhatt
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NSCLC to SCLC Transformation: A Clinical Challenge. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2025-01-16 Kostas A Papavassiliou,Amalia A Sofianidi,Vassiliki A Gogou,Georgios Marinos,Athanasios G Papavassiliou
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Blood Eosinophil Count Stability in COPD and the Eosinophilic Exacerbator Phenotype. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2025-01-15 Federico Baraldi,Samuel Bartlett-Pestle,James P Allinson,Mairi Macleod,Jordina Mah,Chloe Bloom,Aaron Brady-Green,Apolline Marion,Alberto Papi,Jadwiga A Wedzicha,Lydia J Finney
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Rise in Lung Transplantation for Coal Workers' Pneumoconiosis and Silicosis. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2025-01-13 David J Blackley,Noemi B Hall,Jennifer Flattery,Drew A Harris,Kristin J Cummings,A Scott Laney
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Why Molecular Subphenotyping Is Needed in Cardiogenic Shock, and How to Accomplish This? Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2025-01-13 Sabri Soussi,Susanna Price,Alastair Proudfoot,Alexandre Mebazaa,Patrick R Lawler
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Effect of Individualized PEEP Titrated by EIT in Patients with Acute Respiratory Distress Syndrome. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2025-01-09 Xueyan Yuan,Dongyu Chen,Yali Chao,Rui Zhang,Lanqi Guo,Jianfeng Xie,Songqiao Liu,Zhanqi Zhao,Yingzi Huang,Yi Yang,Tommaso Mauri,Haibo Qiu,Ling Liu
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Status of Sepsis Care in European Hospitals: Results from an International Cross-Sectional Survey. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2025-01-09 Christian S Scheer,Evangelos J Giamarellos-Bourboulis,Ricard Ferrer,Evgeny A Idelevich,Djillali Annane,Antonio Artigas,Abdullah Tarik Aslan,Gabriella Bottari,Hjalmar R Bouma,Vladimir Černy,Renata Curić Radivojević,Konstantina Dakou,Ken Dewitte,Mohamed Elbahnasawy,Matthias Gründling,Mohan Gurjar,Johanna Hästbacka,Miltiadis Kyprianou,Said Laribi,Annmarie Lassen,Konstantin Lebedinskii,Jan Máca,Manu L
RATIONALE Early detection, standardized therapy, adequate infrastructure and strategies for quality improvement should constitute essential components of every hospital's sepsis plan. OBJECTIVES To investigate the extent to which recommendations from the sepsis guidelines are implemented and the availability of infrastructure for the care of patients with sepsis in acute hospitals. METHODS A multidisciplinary
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Blowing in the Wind: The Uncertain Impact of Inspiratory Muscle Strength Training in ICU Patients. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2025-01-07 Leo Heunks,Martin Dres
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Lung Ultrasound to Detect Overdistension in Mechanically Ventilated Patients: A Pilot Study. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2025-01-02 Paolo Persona,Ilaria Valeri,Francesco Zarantonello,Edoardo Forin,Emanuele Pivetta,Tommaso Antonio Giacon,Tommaso Pettenuzzo,Giovanni Volpicelli,Paolo Navalesi,
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Deadly Countertops: An Urgent Need to Eliminate Silicosis among Engineered Stone Workers. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2025-01-02 Amy Heinzerling,Robert Harrison,Jennifer Flattery,Jane C Fazio,Sheiphali Gandhi,Kristin J Cummings
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Standard Risk Scores Inadequately Estimate Subclinical Coronary Artery Disease in COPD. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2025-01-02 Ashraf Fawzy,Claus F Vogelmeier
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Impact of Environmental Exposures on the Development and Progression of Fibrotic Interstitial Lung Disease. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2025-01-02 Kerri A Johannson,Ayodeji Adegunsoye,Jürgen Behr,Vincent Cottin,Allan R Glanville,Marilyn K Glassberg,Gillian C Goobie,R Gisli Jenkins,John S Kim,Cathryn T Lee,Carrie A Redlich,Luca Richeldi,Margaret L Salisbury,Terry Tetley,Tamera J Corte
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Impact of the CAPTURE COPD Screening Tool in US Primary Care: A Cluster Randomized Trial. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2024-12-23 Fernando J Martinez,Barbara P Yawn,Daniela Angulo,Camden Lopez,Susan Murray,David Mannino,Stacey Anderson,Rowena Dolor,Nancy Elder,Min Joo,Irfan Khan,Lyndee M Knox,Catherine Meldrum,Elizabeth Peters,Cathie Spino,Hazel Tapp,Byron Thomashow,Linda Zittleman,Randall Brown,Barry Make,MeiLan K Han,
Rationale: The impact of COPD screening on US primary care clinician behavior and patient outcomes is unclear. Objectives: Assess the impact of receiving CAPTURE (COPD Assessment in Primary Care to Identify Undiagnosed Respiratory Disease and Exacerbation Risk) screening scores on clinical and patient outcomes. Methods: Cluster randomized trial included 49 usual care (COPD education only) and 51 intervention
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"Probable Chronic Lung Allograft Dysfunction" Is Definitely Good Enough. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2025-02-01 Michael P Combs,Daniel F Dilling
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Leveraging Peer-Driven Social Support to Improve Care Delivery and Outcomes in Obstructive Sleep Apnea. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2025-02-01 Emerson M Wickwire,Amy M Sawyer
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In Asthma, Change Is the Only Constant. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2025-02-01 Karl J Staples
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Prophylactic Noninvasive Ventilation after Extubation of Obese Patients. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2025-02-01 Arnaud W Thille,Sylvain Le Pape
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Timing for Initiating Home Noninvasive Ventilation in Italy: Beyond Clinical Parameters. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2024-12-19 Claudia Crimi,Annalisa Carlucci
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Atorvastatin in Severity-stratified Pulmonary Sarcoidosis: A Phase II Randomized Controlled Trial. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2024-12-19 Joseph R Fontana,Joel Moss,Dong-Yun Kim,Mario Stylianou,Stewart J Levine,Amisha V Barochia,Nargues Weir,Les R Folio,Huy Michael Do,Vincent Manganiello
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Diaphragm Pacing in Early Critical Illness? A Plea for a Super-relaxed Approach. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2024-12-19 Leo Heunks,Dirk W Donker,Eline Oppersma,Coen A C Ottenheijm,Jonne Doorduin
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Limitations in the Study of Vitamin D Supplementation and Severe Asthma Exacerbations. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2024-12-16 Kuan-Po Cheng,James Cheng-Chung Wei
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The Struggle Continues: Improving Outcomes for Surrogate Decision-Makers after the Intensive Care Unit. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2024-12-16 Katherine R Courtright,James Downar
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Reply to Cheng and Wei: Limitations in the Study of Vitamin D Supplementation and Severe Asthma Exacerbations. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2024-12-16 Franziska J Rosser,Yueh-Ying Han,Juan C Celedón
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Is Disease Stability an Attainable COPD Treatment Goal? Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2024-12-16 Dave Singh,MeiLan K Han,Surya P Bhatt,Marc Miravitlles,Chris Compton,Stefanie Kolterer,Tharishini Mohan,Suneal K Sreedharan,Lee Tombs,David M G Halpin
Chronic obstructive pulmonary disease (COPD) is a heterogenous lung condition characterized by progressive airflow obstruction. Despite advancements in diagnosis and treatment, the disease burden remains high; although clinical trials have shown improvements in outcomes such as exacerbations, quality of life, and lung function, improvement may not be attainable for many patients. For patients who do
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Air Hunger Far Exceeds Dyspnea Sense of Effort During Mechanical Ventilation and a Weaning Trial. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2024-12-16 Amal Jubran,Franco Laghi,Brydon J B Grant,Martin J Tobin
RATIONALE No systematic investigation into dyspnea in patients receiving prolonged ventilation (>21 days) after recovering from critical-illness has been published. OBJECTIVES To determine magnitude, nature and pathophysiological basis of dyspnea during an unassisted-breathing trial in prolonged-ventilation patients. METHODS Dyspnea intensity and descriptor selection were investigated in 27 prolonged-ventilation
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Nasal High Flow to Modulate Dyspnea in Orally Intubated Patients. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2024-12-16 Valentine Le Stang,Mélodie Graverot,Antoine Kimmoun,Marie-Cécile Niérat,Maxens Decavèle,Thomas Similowski,Alexandre Demoule,Martin Dres
RATIONALE High flow therapy reduces dyspnea in acute respiratory failure but the underlying mechanisms are not fully elucidated. OBJECTIVES To compare dyspnea, airway occlusion pressure (P0.1) and inspiratory work with and without nasal high flow (NHF, FiO2 21%, temperature 31°C) in intubated patients under pressure support ventilation and during a spontaneous breathing trial (SBT). METHODS Dyspnea
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Lung Function in the Second Decade of Life in Children after Early HIV Diagnosis and ART Initiation. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2024-12-16 Andre G Gie,Marieke M van der Zalm,Eric D McCollum,Sara Browne,Mark F Cotton,Pierre Goussard,Steve Innes
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Inbuilt Errors: A Call for Standardized Definitions. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2024-12-16 Aman Pande,Philppe Haouzi
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Editorial Position of the American Thoracic Society Journal Family on the Evolving Role of Artificial Intelligence in Scientific Research and Review. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2024-12-16 Nitin Seam,Sanjay H Chotirmall,Fernando J Martinez,Andrew J Halayko,Michael O Harhay,Stephanie D Davis,Paul T Schumacker,Robert M Tighe,Kristin M Burkart,Colin Cooke
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Prevalence and Clinical Correlates of Radiologically Detected Coronary Artery Disease in COPD: A Cross-Sectional Observational Study. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2024-12-16 Mairi A MacLeod,Kristopher D Knott,James P Allinson,Lydia J Finney,Dexter J Wiseman,Andrew I Ritchie,Aaron Braddy-Green,Sam Barlett-Pestell,Ralph Lopez,Logan Sun,Philippa Webb,Paras Dalal,Michael Rubens,Simon Davies,Dorian O Haskard,Anand Devaraj,Gavin C Donaldson,Ramzi Y Khamis,Edward D Nicol,Jadwiga A Wedzicha
RATIONALE Unrecognised coronary artery disease (CAD) may contribute to adverse outcomes in chronic obstructive pulmonary disease (COPD). Improved identification of at-risk groups could inform better preventative care. We aimed to evaluate the burden and relationships of radiologically detectable CAD in COPD, establish frequency of occult disease, and examine potential cardiovascular screening methods
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Pulmonary Arterial Inflammatory Myofibroblastic Tumor in an Adult. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2024-12-11 Ling Zhang,Ling Zhao,Min Liu
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C-reactive Protein-based Screening of People with Tuberculosis Symptoms: A Diagnostic Accuracy Study. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2024-12-06 Brigitta Derendinger,Tessa K Mochizuki,Danaida Marcelo,Deepa Shankar,Wilson Mangeni,Hanh Nguyen,Seda Yerlikaya,William Worodria,Charles Yu,Nhung Viet Nguyen,Devasahayam Jesudas Christopher,Grant Theron,Patrick Pj Phillips,Payam Nahid,Claudia M Denkinger,Adithya Cattamanchi,Christina Yoon
Rationale: C-reactive protein (CRP)-based tuberculosis (TB) screening is recommended for people with HIV (PWH). However, its performance among people without HIV and in diverse settings is unknown. Objectives: In a multi-country study, we aimed to determine whether CRP meets the minimum accuracy targets (sensitivity ≥90%, specificity ≥70%) for an effective TB screening test. Methods/Measurements: Consecutive
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From Liver Insights to Lung Innovations: FGF21 and Idiopathic Pulmonary Fibrosis. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2024-12-06 Andres J Gonzalez Coba,Jarrod W Barnes,Stefanie Krick
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Fluids Matter in Lung Injury but Not Where We Thought. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2024-12-06 Bhushan H Katira,Laurent J Brochard
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Temporal Transitions of the Hyperinflammatory and Hypoinflammatory Phenotypes in Critical Illness. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2024-12-06 Rombout B E van Amstel,Brian Bartek,Alexander P J Vlaar,Elizabeth Gay,Lonneke A van Vught,Olaf L Cremer,Tom Van der Poll,Nathan I Shapiro,Michael A Matthay,Carolyn S Calfee,Pratik Sinha,Lieuwe D J Bos
RATIONALE Systemic molecular phenotypes of critical illness are prognostically informative, yet their temporal kinetics and implications of changing phenotypes remain incompletely understood. OBJECTIVES To determine the temporal nature of the Hyperinflammatory and Hypoinflammatory phenotypes and assess the impact of transition between the phenotypes on mortality. METHODS We used data from one prospective
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Adenolipoma of the Bronchus: An Extremely Rare Benign Tumor. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2024-12-06 Hao Tang,Xin He,Ying Chen,Wenyan Wang,Xianyun Li,Deyu Guo