
样式: 排序: IF: - GO 导出 标记为已读
-
Executive Summary: International Clinical Practice Guidelines for Pediatric Ventilator Liberation, A PALISI Network Document. Am. J. Respir. Crit. Care Med. (IF 30.528) Pub Date : 2022-08-15 Samer Abu-Sultaneh,Narayan Prabhu Iyer,Analía Fernández,Michael Gaies,Sebastián González-Dambrauskas,Justin Christian Hotz,Martin C J Kneyber,Yolanda M López-Fernández,Alexandre T Rotta,David K Werho,Arun Kumar Baranwal,Bronagh Blackwood,Hannah J Craven,Martha A Q Curley,Sandrine Essouri,Jose Roberto Fioretto,Silvia Mm Hartmann,Philippe Jouvet,Steven Kwasi Korang,Gerrard F Rafferty,Padmanabhan Ramnarayan
RATIONALE Pediatric specific ventilator liberation guidelines are lacking despite the many studies exploring elements of extubation readiness testing. The lack of clinical practice guidelines has led to significant and unnecessary variation in methods used to assess pediatric patients' readiness for extubation. METHODS Twenty-six international experts comprised a multi-professional panel to establish
-
Syndrome of Combined Pulmonary Fibrosis and Emphysema: An Official ATS/ERS/JRS/ALAT Research Statement. Am. J. Respir. Crit. Care Med. (IF 30.528) Pub Date : 2022-08-15 Vincent Cottin,Moises Selman,Yoshikazu Inoue,Alyson W Wong,Tamera J Corte,Kevin R Flaherty,MeiLan K Han,Joseph Jacob,Kerri A Johannson,Masanori Kitaichi,Joyce S Lee,Alvar Agusti,Katerina M Antoniou,Pauline Bianchi,Fabian Caro,Matias Florenzano,Liam Galvin,Tae Iwasawa,Fernando J Martinez,Rebecca L Morgan,Jeffrey L Myers,Andrew G Nicholson,Mariaelena Occhipinti,Venerino Poletti,Margaret L Salisbury,Don
Background: The presence of emphysema is relatively common in patients with fibrotic interstitial lung disease. This has been designated combined pulmonary fibrosis and emphysema (CPFE). The lack of consensus over definitions and diagnostic criteria has limited CPFE research. Goals: The objectives of this task force were to review the terminology, definition, characteristics, pathophysiology, and research
-
Forgiveness Is the Attribute of the Strong: Nonadherence and Regimen-Shortening in Drug-Sensitive TB. Am. J. Respir. Crit. Care Med. (IF 30.528) Pub Date : 2022-08-11 Helen R Stagg,Jennifer A Thompson,Marc Ci Lipman,Derek J Sloan,Mary Flook,Katherine L Fielding,
RATIONALE 'Forgiveness' charts the ability of a drug or regimen to withstand non-adherence without negative clinical consequences. OBJECTIVES We aimed to determine the influence of regimen length, regimen drugs and dosing, and when during treatment non-adherence occurs on the forgiveness of anti-tuberculosis regimens. METHODS Using data from three randomised controlled trials comparing experimental
-
Expanding the Reach of Lung Cancer Screening: Risk Models for Individuals Who Never Smoked. Am. J. Respir. Crit. Care Med. (IF 30.528) Pub Date : 2022-08-11 Anil Vachani,Patrick Nana-Sinkam
-
Antifibrotics and Reduced Mortality in Idiopathic Pulmonary Fibrosis: Immortal Time Bias. Am. J. Respir. Crit. Care Med. (IF 30.528) Pub Date : 2022-08-11 Samy Suissa,Karine Suissa
-
Metatranscriptomics of Nasopharyngeal Microbiota and Host Distinguish between Pneumonia and Health. Am. J. Respir. Crit. Care Med. (IF 30.528) Pub Date : 2022-08-10 Priyanka Nannapaneni,John Sundh,Stefanie Prast-Nielsen,Samuel Rhedin,Åke Örtqvist,Pontus Naucler,Birgitta Henriques-Normark
-
Particle Constituents and Oxidative Potential: Insights into Differential PM2.5 Toxicity. Am. J. Respir. Crit. Care Med. (IF 30.528) Pub Date : 2022-08-10 Ana M Rule,Kirsten A Koehler
-
New Insights into the Epigenomic Landscape of Small Cell Lung Cancer: a Game Changer? Am. J. Respir. Crit. Care Med. (IF 30.528) Pub Date : 2022-08-10 Poonam Sarode,Soni Savai Pullamsetti,Rajkumar Savai
-
Evidence for Early CFTR Modulator Treatment for Children with Cystic Fibrosis Keeps Growing. Am. J. Respir. Crit. Care Med. (IF 30.528) Pub Date : 2022-08-10 Jordana E Hoppe,Edith T Zemanick,Stacey L Martiniano
-
Breath of Fresh Air: Towards Unraveling the Molecular Underpinnings of Sleep Apnea. Am. J. Respir. Crit. Care Med. (IF 30.528) Pub Date : 2022-08-09 Brian E Cade,Sina A Gharib
-
Nav1.8 Dysregulates Na and Ca Leading to Arrhythmias in Patients with Sleep-disordered Breathing. Am. J. Respir. Crit. Care Med. (IF 30.528) Pub Date : 2022-08-09 Simon Lebek,Philipp Hegner,Rosa Hultsch,Jonas Rohde,Leopold Rupprecht,Christof Schmid,Samuel Sossalla,Lars Siegfried Maier,Michael Arzt,Stefan Wagner
-
MMP-12 Supports Pulmonary B Cell Follicle Formation and Local Antibody Responses During Asthma. Am. J. Respir. Crit. Care Med. (IF 30.528) Pub Date : 2022-08-09 Chloe J Pyle,Dhiren F Patel,Teresa Peiró,Régis Joulia,Aleksander M Grabiec,Tracy Hussell,Gael Tavernier,Angela Simpson,James Pease,James A Harker,Clare M Lloyd,Robert J Snelgrove
-
Validation of Proposed Criteria for Progressive Pulmonary Fibrosis. Am. J. Respir. Crit. Care Med. (IF 30.528) Pub Date : 2022-08-09 Janelle Vu Pugashetti,Ayodeji Adegunsoye,Zhe Wu,Cathryn T Lee,Anand Srikrishnan,Sahand Ghodrati,Vivian Vo,Elisabetta A Renzoni,Athol U Wells,Christine Kim Garcia,Felix Chua,Chad A Newton,Philip L Molyneaux,Justin M Oldham
RATIONALE Criteria for progressive pulmonary fibrosis (PPF) have been proposed, but their prognostic value beyond categorical decline in forced vital capacity (FVC) remains unclear. OBJECTIVE To determine whether proposed PPF criteria predict transplant-free survival (TFS) in patients with non-idiopathic pulmonary fibrosis (IPF) forms of interstitial lung disease (ILD). METHODS A retrospective, multi-center
-
In Utero and Childhood/Adolescence Exposure to Tobacco Smoke, Genetic Risk and Lung Cancer Incidence and Mortality in Adulthood. Am. J. Respir. Crit. Care Med. (IF 30.528) Pub Date : 2022-08-09 Heng He,Ming-Ming He,Haoxue Wang,Weihong Qiu,Lei Liu,Lu Long,Qian Shen,Shanshan Zhang,Shifan Qin,Zequn Lu,Yimin Cai,Ming Zhang,Siyuan Niu,Jiaoyuan Li,Na Shen,Ying Zhu,Jianbo Tian,Jiang Chang,Xiaoping Miao,Rong Zhong
RATIONALE The individual effects of early-life tobacco smoke exposure and its interactions with genetic factors on lung cancer in adulthood remain unclear. OBJECTIVES To investigate the associations between early-life tobacco exposures as well as their interactions with polygenic risk scores (PRSs) and lung cancer incidence and mortality. METHODS A total of 432,831 participants from the UK Biobank
-
Patient Characteristics and Survival for Progressive Pulmonary Fibrosis Using Different Definitions. Am. J. Respir. Crit. Care Med. (IF 30.528) Pub Date : 2022-08-09 Yet H Khor,Malik Farooqi,Nathan Hambly,Martin Kolb,Christopher J Ryerson,
-
Extracellular Vesicle-Encapsulated microRNAs as Novel Biomarkers of Lung Health. Am. J. Respir. Crit. Care Med. (IF 30.528) Pub Date : 2022-08-09 Christina M Eckhardt,Simone Gambazza,Tessa R Bloomquist,Peter De Hoff,Aishwarya Vuppala,Pantel S Vokonas,Augusto A Litonjua,David Sparrow,Faruque Parvez,Louise C Laurent,Joel Schwartz,Andrea A Baccarelli,Haotian Wu
RATIONALE Early detection of respiratory diseases is critical to facilitate delivery of disease-modifying interventions. Extracellular vesicle-enriched microRNAs (EV-miRNAs) may represent reliable markers of early lung injury. OBJECTIVE Evaluate associations of plasma EV-miRNAs with lung function. METHODS The prospective Normative Aging Study (NAS) collected plasma EV-miRNA measurements from 1996-2015
-
Dying with OSA, or From It: A Cautionary Note about Novel Hypoxia Metrics. Am. J. Respir. Crit. Care Med. (IF 30.528) Pub Date : 2022-08-08 Jonathan C Jun
-
Mucins MUC5AC and MUC5B in the airways: MUCing around together. Am. J. Respir. Crit. Care Med. (IF 30.528) Pub Date : 2022-08-08 Mehmet Kesimer
-
Understanding Sex-based Differences in ICU Mortality: Moving Beyond the Biology. Am. J. Respir. Crit. Care Med. (IF 30.528) Pub Date : 2022-08-08 Elizabeth M Viglianti,Christina Yek,Sameer S Kadri
-
Suspected Interstitial Lung Disease in COPDGene. Am. J. Respir. Crit. Care Med. (IF 30.528) Pub Date : 2022-08-05 Jonathan A Rose,Aravind A Menon,Takuya Hino,Akinori Hata,Mizuki Nishino,David A Lynch,Ivan O Rosas,Souheil El-Chemaly,Benjamin A Raby,Samuel Y Ash,Bina Choi,George R Washko,Edwin K Silverman,Michael H Cho,Hiroto Hatabu,Rachel K Putman,Gary M Hunninghake
RATIONALE While interstitial lung abnormalities (ILA), specific patterns of incidentally-detected abnormal density on computed tomography (CT), have been associated with abnormal lung function and increased mortality, it is unclear if a subset with incidental interstitial lung disease (ILD) accounts for these adverse consequences. OBJECTIVES To define the prevalence and risk factors of suspected ILD
-
Pulmonary Surfactant Proteins are Inhibited by IgA Autoantibodies in Severe COVID-19. Am. J. Respir. Crit. Care Med. (IF 30.528) Pub Date : 2022-08-04 Tobias Sinnberg,Christa Lichtensteiger,Omar Hasan Ali,Oltin T Pop,Ann-Kristin Jochum,Lorenz Risch,Silvio D Brugger,Ana Velic,David Bomze,Philipp Kohler,Pietro Vernazza,Werner C Albrich,Christian R Kahlert,Maire-Therese Abdou,Nina Wyss,Kathrin Hofmeister,Heike Niessner,Carl Zinner,Mara Gilardi,Alexandar Tzankov,Martin Röcken,Alex Dulovic,Srikanth Mairpady Shambat,Natalia Ruetalo,Philipp K Buehler,Thomas
RATIONALE Coronavirus disease 2019 (COVID-19) can lead to acute respiratory distress syndrome with fatal outcomes. Evidence suggests that dysregulated immune responses, including autoimmunity, are key pathogenic factors. OBJECTIVES To assess whether IgA autoantibodies target lung-specific proteins and contribute to disease severity. METHODS We collected 147 blood, 9 lung tissue, and 36 bronchoalveolar
-
Understanding Genotype-Phenotype Correlations in Patients with TBX4 Mutations: New Views Inside and Outside the Box. Am. J. Respir. Crit. Care Med. (IF 30.528) Pub Date : 2022-08-04 Mary P Mullen
-
Prognostic Value of Exercise- as Compared to Resting Pulmonary Hemodynamics in Patients with Normal or Mildly Elevated Pulmonary Arterial Pressure. Am. J. Respir. Crit. Care Med. (IF 30.528) Pub Date : 2022-08-04 Philipp Douschan,Alexander Avian,Vasile Foris,Teresa Sassmann,Gerhard Bachmaier,Piet Rosenstock,Katarina Zeder,Horst Olschewski,Gabor Kovacs
-
The Exposome Applied: A Step Toward Defining the Totality of Environmental Exposures in Asthma. Am. J. Respir. Crit. Care Med. (IF 30.528) Pub Date : 2022-08-04 Fenna C M Sillé,Meredith McCormack,Thomas Hartung
-
New Tools for Old Problems: Gastroesophageal Reflux Disease and the Lung Allograft Microbiome. Am. J. Respir. Crit. Care Med. (IF 30.528) Pub Date : 2022-08-04 Allan R Glanville,Alicia B Mitchell
-
Taking for Granted Conclusions from Studies that Cannot Prove Causality of Respiratory Symptoms and Vaping. Am. J. Respir. Crit. Care Med. (IF 30.528) Pub Date : 2022-08-03 Davide Campagna,Grazia Caci
-
Xie and Stokes Reply to: "Taking for Granted Conclusions from Studies that Cannot Prove Causality of Respiratory Symptoms and Vaping." Am. J. Respir. Crit. Care Med. (IF 30.528) Pub Date : 2022-08-03 Wubin Xie,Andrew Stokes
-
Anti-Acid Therapies in Idiopathic Pulmonary Fibrosis: Premature to Dismiss? Am. J. Respir. Crit. Care Med. (IF 30.528) Pub Date : 2022-08-03 Louise E Crowley,Andrew Wilson,David R Thickett
-
Care Quality for Patients with Chronic Obstructive Pulmonary Disease in the Readmission Penalty Era. Am. J. Respir. Crit. Care Med. (IF 30.528) Pub Date : 2022-08-02 Juan C Rojas,Sukarn Chokkara,Mengqi Zhu,Peter K Lindenauer,Valerie G Press
RATIONALE COPD is the 5th-leading cause of admissions and third-leading cause of readmissions among US adults. Recent policies instituted financial penalties for excessive COPD readmissions. OBJECTIVES To evaluate changes in the quality of care for patients hospitalized for COPD following implementation of the Hospital Readmissions Reduction Program (HRRP). METHODS Retrospective cohort study of patients
-
Definition and Nomenclature of Chronic Obstructive Pulmonary Disease: Time for its Revision. Am. J. Respir. Crit. Care Med. (IF 30.528) Pub Date : 2022-08-01 Bartolome Celli,Leonardo Fabbri,Gerard Criner,Fernando J Martinez,David Mannino,Claus Vogelmeier,Maria Montes de Oca,Alberto Papi,Don D Sin,MeiLan K Han,Alvar Agusti
-
Using Real-world Data to Understand who has Cardiovascular Benefits from CPAP: The Importance of Male Sex, Excessive Sleepiness and Primary Prevention. Am. J. Respir. Crit. Care Med. (IF 30.528) Pub Date : 2022-08-01 Brendan T Keenan,Raphael Heinzer
-
Rare Genetic Variants Provide Protection for Obstructive Sleep Apnea. Am. J. Respir. Crit. Care Med. (IF 30.528) Pub Date : 2022-07-29 Allan I Pack,Brendan T Keenan
-
HFNC Oxygen Therapy for Stable Hypercapnic COPD: Just Good Enough?. Am. J. Respir. Crit. Care Med. (IF 30.528) Pub Date : 2022-07-29 Yi Wang,Yong Jie Ding,Qing Yun Li
-
Cognitive Dysfunction in Patients with Pulmonary Hypertension. Am. J. Respir. Crit. Care Med. (IF 30.528) Pub Date : 2022-07-29 Ping Yuan,Jinling Li,Jianhui Liu,Hongting Liu,Sugang Gong,Lan Wang,Jinming Liu,Congcong Li,Yi Wang,Xiaohuan Xia,Jialin C Zheng
-
A Case of Catathrenia Captured on Polysomnography with Audio-Visual Recording. Am. J. Respir. Crit. Care Med. (IF 30.528) Pub Date : 2022-07-28 Anusha Devarajan,Miranda R Roderick,Bernie W Miller,Chad M Ruoff
-
A Risk-Stratifieed Approach for Never- and Ever-Smokers in Lung Cancer Screening: A Prospective Cohort Study in China. Am. J. Respir. Crit. Care Med. (IF 30.528) Pub Date : 2022-07-28 Fei Wang,Fengwei Tan,Sipeng Shen,Zheng Wu,Wei Cao,Yiwen Yu,Xuesi Dong,Changfa Xia,Wei Tang,Yongjie Xu,Chao Qin,Meng Zhu,Jibin Li,Zhuoyu Yang,Yadi Zheng,Zilin Luo,Liang Zhao,Jiang Li,Jiansong Ren,Jufang Shi,Yao Huang,Ning Wu,Hongbing Shen,Wanqing Chen,Ni Li,Jie He
RATIONALE Over 40% lung cancer cases occurred in never-smokers in China. However, high-risk never-smokers were precluded benefiting from the lung cancer screening as most screening guidelines did not consider them. OBJECTIVES We sought to develop and validate prediction models for three-year lung cancer risks for never- and ever-smokers (China NCC-LCm2021 models). METHODS 425 626 never-smokers and
-
Reply to: Extracorporeal membrane oxygenation transport for severe COVID-19 - why we can and should! Am. J. Respir. Crit. Care Med. (IF 30.528) Pub Date : 2022-07-26 Whitney D Gannon,John W Stokes,Sean A Francois,Yatrik J Patel,Meredith E Pugh,Clayne Benson,Todd W Rice,Matthew Bacchetta,Matthew W Semler,Jonathan D Casey
-
Heatwaves and Air Pollution - A Deadly Combination. Am. J. Respir. Crit. Care Med. (IF 30.528) Pub Date : 2022-07-25 Patrick L Kinney,Kent E Pinkerton
NA.
-
Creatine Kinase is Decreased in Childhood Asthma. Am. J. Respir. Crit. Care Med. (IF 30.528) Pub Date : 2022-07-23 Stefano Guerra,Julie G Ledford,Erik Melén,Iris Lavi,Anne-Elie Carsin,Debra A Stern,Jing Zhai,Marta Vidal,Mariona Bustamante,Kenneth J Addison,Renata G Vallecillo,Dean Billheimer,Gerard H Koppelman,Judith Garcia-Aymerich,Nathanaël Lemonnier,Montserrat Fitó,Carlota Dobaño,Simon Kebede Merid,Inger Kull,Rosemary R C McEachan,John Wright,Leda Chatzi,Manolis Kogevinas,Daniela Porta,Silvia Narduzzi,Ferran
RATIONALE The identification of novel molecules associated with asthma may provide insights into mechanisms of disease and their potential clinical implications. OBJECTIVES To conduct a screening of circulating proteins in childhood asthma and to study proteins emerged from human studies in a mouse model of asthma. METHODS We included 2,264 children from eight birth cohorts from the MeDALL project
-
Statistical Concern Regarding the Relationship of Change in Mucus Plug Score with Airflow Over Time. Am. J. Respir. Crit. Care Med. (IF 30.528) Pub Date : 2022-07-23 Tokunori Ikeda,Yusuke Tomita
-
The Recruitment-to-Inflation Ratio is Correlated with EIT-Derived Collapse and Overdistention in COVID-19 ARDS. Am. J. Respir. Crit. Care Med. (IF 30.528) Pub Date : 2022-07-23 Tommaso Pettenuzzo,Nicolò Sella,Giulia Lorenzoni,Alvise Calore,Francesco Zarantonello,Giulio Andreatta,Alessandro De Cassai,Dario Gregori,Annalisa Boscolo,Paolo Navalesi
-
Lung Allograft Microbiome Association with Gastroesophageal Reflux, Inflammation, and Allograft Dysfunction. Am. J. Respir. Crit. Care Med. (IF 30.528) Pub Date : 2022-07-23 Pierre H H Schneeberger,Chen Yang Kevin Zhang,Jessica Santilli,Bo Chen,Wei Xu,Youngho Lee,Zonelle Wijesinha,Elaine Reguera-Nuñez,Noelle Yee,Musawir Ahmed,Kristen Boonstra,Rayoun Ramendra,Courtney W Frankel,Scott M Palmer,Jamie L Todd,Tereza Martinu,Bryan Coburn
RATIONALE It remains unclear how gastroesophageal reflux disease (GERD) affects allograft microbial community composition in lung transplant recipients, and its impact on lung allograft inflammation and function. OBJECTIVES Our objective was to compare the allograft microbiota in lung transplant recipients with or without clinically diagnosed GERD in the first post-transplant year, and assess associations
-
Reply to: Statistical Concern Regarding the Relationship of Change in Mucus Plug Score with Airflow Over Time. Am. J. Respir. Crit. Care Med. (IF 30.528) Pub Date : 2022-07-23 Monica Tang,David T Mauger,John V Fahy,Eleanor M Dunican
-
Progressive Pulmonary Fibrosis: Putting the Cart Before the Horse. Am. J. Respir. Crit. Care Med. (IF 30.528) Pub Date : 2022-07-22 Kerri A Johannson,Martin Kolb,Jolene H Fisher,Simon Lf Walsh
-
Comment on "Idiopathic Pulmonary Fibrosis (an Update) and Progressive Pulmonary Fibrosis in Adults". Am. J. Respir. Crit. Care Med. (IF 30.528) Pub Date : 2022-07-22 Mary Beth Scholand,Athol U Wells
-
Progressive Pulmonary Fibrosis: Should the Timelines be Taken Out of the Definition? Am. J. Respir. Crit. Care Med. (IF 30.528) Pub Date : 2022-07-22 Vincent Cottin,Kevin K Brown,Kevin Flaherty,Athol U Wells
-
Reply to: Microbial Burden-Associated Cytokine Storm May Explain Non-Resolving ARDS in COVID-19 Patients. Am. J. Respir. Crit. Care Med. (IF 30.528) Pub Date : 2022-07-22 Robert F J Kullberg,Justin de Brabander,Leonoor S Boers,Lieuwe D J Bos,W Joost Wiersinga
-
Microbial Burden-Associated Cytokine Storm May Explain Non-Resolving ARDS in COVID-19 Patients. Am. J. Respir. Crit. Care Med. (IF 30.528) Pub Date : 2022-07-22 Taro Yasuma,Corina N D'Alessandro-Gabazza,Tetsu Kobayashi,Esteban C Gabazza,Hajime Fujimoto
-
Reply to: Heart Rate Response in OSA: A Clue to Reveal Cardiovascular Benefit from CPAP? Am. J. Respir. Crit. Care Med. (IF 30.528) Pub Date : 2022-07-21 Ali Azarbarzin,Andrey Zinchuk,Yüksel Peker,Scott A Sands,
-
Heart Rate Response in OSA: A Clue to Reveal Cardiovascular Benefit from CPAP? Am. J. Respir. Crit. Care Med. (IF 30.528) Pub Date : 2022-07-21 Zhihua Huang,Qin Luo,Jiyan Chen,Ling Wang,Zhihong Liu
-
The MI-PICC Score: A Risk-Prediction Model for PICC-Associated Complications in the ICU. Am. J. Respir. Crit. Care Med. (IF 30.528) Pub Date : 2022-07-21 Sushant Govindan,Megan E O'Malley,Scott A Flanders,Vineet Chopra
-
Intrapulmonary Bronchopulmonary Anastomoses in Severe COVID-19-related Acute Respiratory Failure. Am. J. Respir. Crit. Care Med. (IF 30.528) Pub Date : 2022-07-20 Jenna Bodmer,Alice Levin,Christian Westöö,Oscar van der Have,Niccolò Peruzzi,Karin Tran-Lundmark,Steven H Abman,Csaba Galambos
-
Rare Case of Isolated Systemic Arterial Supply to Upper Lobe of Left Lung. Am. J. Respir. Crit. Care Med. (IF 30.528) Pub Date : 2022-07-20 Navjot Kaur,Swathi Raman,Vruksha Upadhyay,Maruti Kumaran,Parth Rali,Massa Zantah
-
An Experimental Human Colonization Model with Pneumococcal Serotype 3 has the Potential to be Used for Vaccine Studies. Am. J. Respir. Crit. Care Med. (IF 30.528) Pub Date : 2022-07-20 Birgitta Henriques-Normark,Ana Rita Narciso
-
A New Era for Cystic Fibrosis and CFTR Modulator Trials in Infants. Am. J. Respir. Crit. Care Med. (IF 30.528) Pub Date : 2022-07-20 Claire E Wainwright
-
Science-Based Policy Recommendations for PM2.5 in the United States. Am. J. Respir. Crit. Care Med. (IF 30.528) Pub Date : 2022-07-20 Kevin R Cromar,Alison G Lee,Jack R Harkema,Isabella Annesi-Maesano
-
High Flow Nasal Oxygen at Home to Prevent COPD Exacerbations? Am. J. Respir. Crit. Care Med. (IF 30.528) Pub Date : 2022-07-19 Jean-Pierre Frat,Arnaud W Thille
-
High-Flow Versus VenturiMask Oxygen Therapy to Prevent Re-Intubation in Hypoxemic Patients After Extubation: A Multicenter, Randomized Clinical Trial. Am. J. Respir. Crit. Care Med. (IF 30.528) Pub Date : 2022-07-18 Salvatore Maurizio Maggiore,Samir Jaber,Domenico Luca Grieco,Jordi Mancebo,Spyros Zakynthinos,Alexandre Demoule,Jean-Damien Ricard,Paolo Navalesi,Rosanna Vaschetto,Sami Hraiech,Kada Klouche,Jean-Pierre Frat,Virginie Lemiale,Vito Fanelli,Gerald Chanques,Daniele Natalini,Eleni Ischaki,Danielle Reuter,Indalecio Morán,Béatrice La Combe,Federico Longhini,Andrea De Gaetano,V Marco Ranieri,Laurent J Brochard
RATIONALE When compared to VenturiMask after extubation, high-flow nasal oxygen provides physiological advantages. OBJECTIVE To establish whether high-flow oxygen prevents endotracheal re-intubation in hypoxemic patients after extubation, as compared to VenturiMask. METHODS In this multicentre randomized trial, 494 patients exhibiting PaO2:FiO2 ratio≤300 mmHg after extubation were randomly assigned
-
Performance of Early Capillary Refill Time Measurement on Outcomes in Cardiogenic Shock: An Observational, Prospective Multicentric Study. Am. J. Respir. Crit. Care Med. (IF 30.528) Pub Date : 2022-07-18 Hamid Merdji,Anais Curtiaud,Antoine Aheto,Antoine Studer,Veli-Pekka Harjola,Alexandra Monnier,Kevin Duarte,Nicolas Girerd,Marion Kibler,Hafid Ait-Oufella,Julie Helms,Alexandre Mebazaa,Bruno Levy,Antoine Kimmoun,Ferhat Meziani
BACKGROUND Identification of cardiogenic shock severity is a critical step to adapt the management level upon admission. Peripheral tissue perfusion signs, simple and reliable markers of tissue hypoperfusion have never been extensively assessed during cardiogenic shock. METHODS All consecutive patients admitted in ICU for cardiogenic shock of two tertiary teaching hospitals were included in a prospective
-
Sex Differences in Mortality of ICU Patients According to Diagnosis-Related sex Balance. Am. J. Respir. Crit. Care Med. (IF 30.528) Pub Date : 2022-07-18 Lucy J Modra,Alisa M Higgins,David V Pilcher,Michael J Bailey,Rinaldo Bellomo
RATIONALE Women have worse outcomes than men in several conditions more common in men, including cardiac surgery and burns. OBJECTIVES To describe the relationship between sex balance within each diagnostic group of ICU admissions; defined as the percentage of patients who were women; and hospital mortality of women compared to men with that same diagnosis. METHODS We studied ICU patients in the Australia