RATIONALE Respiratory resistance (Rrs) and reactance (Xrs) measured by oscillometry and their intra-breath changes have emerged as sensitive parameters for detecting early pathological impairments during tidal breathing. OBJECTIVES This study evaluates the prevalence and association of abnormal oscillometry parameters with respiratory symptoms and respiratory diseases in a general adult population. METHODS 7560 participants of the Austrian LEAD (Lung, hEart, sociAl, boDy) study with oscillometry measurements (Resmon Pro FULL, Restech Srl) were included in this study. The presence of respiratory symptoms and doctor-diagnosed respiratory diseases was assessed by an interview-based questionnaire. Rrs and Xrs at 5 Hz, their inspiratory and expiratory components, the area above the Xrs curve, and the presence of tidal expiratory flow limitation were analyzed. Normality ranges for oscillometry parameters were defined according to Oostveen et al. (2013). MEASUREMENTS AND MAIN RESULTS The overall prevalence of abnormal oscillometry parameters was 20%. The incidence (CI) of abnormal oscillometry increased in the presence of symptoms and/or diagnoses (17% (16 - 18%) vs 27% (25 - 29%), p<0.0001). All abnormal oscillometry parameters except Rrs at 5 Hz were significantly associated with respiratory symptoms/diseases. Significant associations were found even in subjects with normal spirometry, with abnormal oscillometry incidence rate increasing by 6% (4 - 8%, p<0.0001) in subjects with symptoms or diagnoses. CONCLUSIONS Abnormal oscillometry parameters are present in 1/5 of this adult population and are significantly associated with respiratory symptoms and disease. Our findings underscore the potential of oscillometry as a tool for detecting and evaluating respiratory impairments, even in individuals with normal spirometry. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/).

中文翻译：

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示波法的诊断潜力：基于人群的方法。

基本原理 通过示波法测量的呼吸阻力 (Rrs) 和电抗 (Xrs) 及其呼吸内变化已成为检测潮式呼吸期间早期病理损伤的敏感参数。目的 本研究评估一般成年人群中异常示波参数与呼吸道症状和呼吸道疾病的患病率及其关联。方法 本研究纳入了奥地利 LEAD（肺、心脏、社会、身体）研究的 7560 名参与者，使用示波测量法（Resmon Pro FULL、Restech Srl）。通过访谈问卷评估是否存在呼吸道症状和医生诊断的呼吸道疾病。分析了 5 Hz 时的 Rrs 和 Xrs、它们的吸气和呼气分量、Xrs 曲线上方的面积以及潮气呼气流量限制的存在。示波参数的正态范围是根据 Oostveen 等人定义的。（2013）。测量和主要结果 示波参数异常的总体发生率为 20%。存在症状和/或诊断时，示波异常的发生率 (CI) 增加（17% (16 - 18%) vs 27% (25 - 29%)，p<0.0001）。除 5 Hz 的 Rrs 外，所有异常示波参数均与呼吸道症状/疾病显着相关。即使在肺量测定正常的受试者中也发现了显着的相关性，在有症状或诊断的受试者中，示波测定异常发生率增加了 6% (4 - 8%, p<0.0001)。结论 1/5 的成年人存在示波参数异常，并且与呼吸道症状和疾病显着相关。我们的研究结果强调了示波测量法作为检测和评估呼吸损伤的工具的潜力，即使对于肺量测定正常的个体也是如此。本文是开放获取的，并根据知识共享署名非商业性无衍生许可证 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/) 的条款进行分发。