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Microbiota, not host origin drives ex vivo intestinal epithelial responses Gut Microbes (IF 10.245) Pub Date : 2022-06-26 Kaline Arnauts, Padhmanand Sudhakar, Sare Verstockt, Cynthia Lapierre, Selina Potche, Clara Caenepeel, Bram Verstockt, Jeroen Raes, Séverine Vermeire, João Sabino, Catherine Verfaillie, Marc Ferrante
ABSTRACT Microbial dysbiosis is an established finding in patients with inflammatory bowel disease (IBD), but host-microbial interactions are poorly understood. We aimed to unravel the effect of microbiota exposure on intestinal epithelial cells. Confluent Transwell® organoid monolayers of eight UC patients and eight non-IBD controls were co-cultured for six hours with microbiota (3x108 cells) of UC
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Intestinal accumulation of microbiota-produced succinate caused by loss of microRNAs leads to diarrhea in weanling piglets Gut Microbes (IF 10.245) Pub Date : 2022-06-26 Xihong Zhou, Yonghui Liu, Xia Xiong, Jingqing Chen, Wenjie Tang, Liuqin He, Zhigang Zhang, Yulong Yin, Fengna Li
ABSTRACT Diarrheal disease is a common health problem with complex causality. Although diarrhea is accompanied by disturbances in microbial diversity, how gut microbes are involved in the occurrence of diarrhea remains largely unknown. Here, using a pig model of post-weaning stress-induced diarrhea, we aim to elucidate and enrich the mechanistic basis of diarrhea. We found significant alterations in
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Interferon regulatory factor 1 (IRF1) controls the metabolic programmes of low-grade pancreatic cancer cells Gut (IF 23.059) Pub Date : 2022-06-24 Gabriele Alfarano, Matteo Audano, Pierluigi Di Chiaro, Chiara Balestrieri, Marta Milan, Sara Polletti, Paola Spaggiari, Alessandro Zerbi, Giuseppe Riccardo Diaferia, Nico Mitro, Gioacchino Natoli
Objective Pancreatic ductal adenocarcinomas (PDACs) include heterogeneous mixtures of low-grade cells forming pseudoglandular structures and compact nests of high-grade cells organised in non-glandular patterns. We previously reported that low-grade PDAC cells display high expression of interferon regulatory factor 1 (IRF1), a pivotal transcription factor of the interferon (IFN) system, suggesting
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Transcolonic natural orifice transluminal endoscopic surgery (NOTES) is a promising technique for but not limited to periappendiceal lesions Gut (IF 23.059) Pub Date : 2022-06-24 Tao Chen, Meidong Xu
We thank Shah S et al 1 for their interest in our study about a promising natural orifice transluminal endoscopic surgery (NOTES) technique, transcolonic endoscopic appendicectomy (TEA).2 We are happy to respond to their comments. With the development of flexible endoscope, endoscopic surgery is opening a door for NOTES. Similarly, TEA eliminates abdominal incisions and has several advantages.3 However
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Activation of NOTCH signaling via DLL1 is mediated by APE1-redox-dependent NF-κB activation in oesophageal adenocarcinoma Gut (IF 23.059) Pub Date : 2022-06-24 Lei Chen, Heng Lu, Dunfa Peng, Long Long Cao, Farah Ballout, Kannappan Srirmajayam, Zheng Chen, Ajaz Bhat, Timothy C Wang, Anthony Capobianco, Jianwen Que, Oliver Gene McDonald, Alexander Zaika, Shutian Zhang, Wael El-Rifai
Objective Oesophageal adenocarcinoma (EAC) arises in the setting of Barrett’s oesophagus, an intestinal metaplastic precursor lesion that can develop in patients with chronic GERD. Here, we investigated the role of acidic bile salts, the mimicry of reflux, in activation of NOTCH signaling in EAC. Design This study used public databases, EAC cell line models, L2-IL1β transgenic mouse model and human
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Response to letter Gastroenterology (IF 22.682) Pub Date : 2022-06-26 Longlong Cao, Heng Lu, Wael El-Rifai
Abstract not available
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Reply: Challenging the dogma of ω-3 polyunsaturated fatty acids Gastroenterology (IF 22.682) Pub Date : 2022-06-26 Julian Schwärzler, Lisa Mayr, Timon E. Adolph
Abstract not available
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Western-style Diet, pks Island-Carrying Escherichia coli, and Colorectal Cancer: Analyses from Two Large Prospective Cohort Studies Gastroenterology (IF 22.682) Pub Date : 2022-06-24 Kota Arima, Rong Zhong, Tomotaka Ugai, Melissa Zhao, Koichiro Haruki, Naohiko Akimoto, Mai Chan Lau, Kazuo Okadome, Raaj S. Mehta, Juha P. Väyrynen, Junko Kishikawa, Tyler S. Twombly, Shanshan Shi, Kenji Fujiyoshi, Keisuke Kosumi, Yoko Ogata, Hideo Baba, Fenglei Wang, Shuji Ogino
BACKGROUND AND AIMS Evidence supports a carcinogenic role of Escherichia coli carrying the polyketide synthase (pks) island that encodes enzymes for colibactin biosynthesis. We hypothesized that the association of western-style diet (rich in red and processed meat) with colorectal cancer incidence might be stronger for tumors containing higher amounts of pks+ E. coli. METHODS Western diet score was
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Interactions among the mycobiome, bacteriome, inflammation, and diet in people living with HIV Gut Microbes (IF 10.245) Pub Date : 2022-06-23 María José Gosalbes, Nuria Jimenéz-Hernandéz, Elena Moreno, Alejandro Artacho, Xavier Pons, Sonia Ruíz-Pérez, Beatriz Navia, Vicente Estrada, Mónica Manzano, Alba Talavera-Rodriguez, Nadia Madrid, Alejandro Vallejo, Laura Luna, José A. Pérez-Molina, Santiago Moreno, Sergio Serrano-Villar
ABSTRACT While the intestinal microbiome seems a major driver of persistent immune defects in people with HIV (PWH), little is known about its fungal component, the mycobiome. We assessed the inter-kingdom mycobiome–bacteriome interactions, the impact of diet, and the association with the innate and adaptive immunity in PWH on antiretroviral therapy. We included 24 PWH individuals and 12 healthy controls
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Proactive Therapeutic Drug Monitoring vs. Conventional Management for Inflammatory Bowel Diseases: A Systematic Review and Meta-analysis Gastroenterology (IF 22.682) Pub Date : 2022-06-24 Nghia H. Nguyen, Virginia Solitano, Sudheer K. Vuyyuru, John K. MacDonald, Silje W. Syversen, Kristin Kaasen Jørgensen, Eileen Crowley, Christopher Ma, Vipul Jairath, Siddharth Singh
Background and Aims Proactive therapeutic drug monitoring (TDM) has been proposed to improve outcomes in patients with inflammatory bowel disease (IBD) treated with tumor necrosis factor (TNF)α antagonists. We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) comparing proactive TDM with conventional management in patients with IBD. Methods We identified RCTs in
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Ten steps to eliminating hepatitis C in hospitals Nat. Rev. Gastroenterol. Hepatol. (IF 46.802) Pub Date : 2022-06-23 José Luis Calleja, Antonio Aguilera, Maria Buti, Javier Crespo, Federico García, Francisco Jorquera, Luis Enrique Morano, Juan Macias, Jeffrey V. Lazarus
Only 12 high-income countries are on track to meet the World Health Organization’s goal of eliminating hepatitis C as a public health threat by 2030, and micro-elimination opportunities in high-risk populations in settings such as hospitals are often overlooked. We propose ten steps to eliminate hepatitis C in hospitals.
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Salmonella enterica subsp. II serovar 4,5,12:a:- may cause gastroenteritis infections in humans Gut Microbes (IF 10.245) Pub Date : 2022-06-22 Meiying Yan, Yongming Zhou, Yang Cao, Zhenpeng Li, Xin Lu, Bo Pang, Shukun Wang, Biao Kan
ABSTRACT Some serovars of Salmonella are not or rare found to cause salmonellosis in human. In our clinic-based surveillance, three rare Salmonella 4,5,12:a:- strains were recovered from three patients with diarrhea. To explore their genetic and epidemiological characteristics and pathogenesis, we conducted whole-genome sequencing, in vitro invasion assays in mammalian cells, and in vivo virulence
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Blockade of interleukin 10 potentiates antitumour immune function in human colorectal cancer liver metastases Gut (IF 23.059) Pub Date : 2022-06-23 Kevin M Sullivan, Xiuyun Jiang, Prajna Guha, Christopher Lausted, Jason A Carter, Cynthia Hsu, Kevin P Labadie, Karan Kohli, Heidi L Kenerson, Sara K Daniel, Xiaowei Yan, Changting Meng, Arezou Abbasi, Marina Chan, Y David Seo, James O Park, Ian Nicholas Crispe, Raymond S Yeung, Teresa S Kim, Taranjit S Gujral, Qiang Tian, Steven C Katz, Venu G Pillarisetty
Objective Programmed cell death protein 1 (PD-1) checkpoint inhibition and adoptive cellular therapy have had limited success in patients with microsatellite stable colorectal cancer liver metastases (CRLM). We sought to evaluate the effect of interleukin 10 (IL-10) blockade on endogenous T cell and chimeric antigen receptor T (CAR-T) cell antitumour function in CRLM slice cultures. Design We created
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Escape from cell-cell and cell-matrix adhesion dependence underscores disease progression in gastric cancer organoid models Gut (IF 23.059) Pub Date : 2022-06-22 Yin Tong, Priscilla S W Cheng, Chung Sze Or, Sarah S K Yue, Hoi Cheong Siu, Siu Lun Ho, Simon Y K Law, Wai Yin Tsui, Dessy Chan, Stephanie Ma, Siu Po Lee, Annie S Y Chan, April S Chan, Shui Wa Yun, Ho Sang Hui, Siu Tsan Yuen, Suet Yi Leung, Helen H N Yan
Objective Cell-cell (CC) and cell-matrix (CM) adhesions are essential for epithelial cell survival, yet dissociation-induced apoptosis is frequently circumvented in malignant cells. Design We explored CC and CM dependence in 58 gastric cancer (GC) organoids by withdrawing either ROCK inhibitor, matrix or both to evaluate their tumorigenic potential in terms of apoptosis resistance, correlation with
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Further research needed to determine first-line therapy for IBS in primary care Gut (IF 23.059) Pub Date : 2022-06-22 Anupam Rej, David S Sanders, Imran Aziz
We read with great interest the excellent study by Carbone et al ,1 which evaluated the role of a fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAP)-lowering diet versus otilonium bromide (OB) in patients with irritable bowel syndrome (IBS). The study is an important addition to the growing literature evaluating the role of diets in IBS,2 but is unique by being the first
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Dosing of Rifaximin Soluble Solid Dispersion Tablets in Adults With Cirrhosis: 2 Randomized, Placebo-Controlled Trials Clin. Gastroenterol. Hepatol. (IF 11.382) Pub Date : 2022-06-22 Jasmohan S. Bajaj, Tarek I. Hassanein, Nikolaos T. Pyrsopoulos, Arun J. Sanyal, Robert S. Rahimi, Zeev Heimanson, Robert J. Israel, Don C. Rockey
BACKGROUND & AIMS Cirrhosis-related complications are a major burden. Rifaximin soluble solid dispersion (SSD) tablets (immediate-release [IR]; sustained extended-release [SER]) were designed to increase rifaximin water solubility. These analyses evaluate dosing for prevention of cirrhosis complication-related hospitalizations/mortality and overt hepatic encephalopathy (OHE) treatment. METHODS Two
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On the Importance of Safe Access to Reproductive Options for Adolescents and Women with Liver Disease Gastroenterology (IF 22.682) Pub Date : 2022-06-22 Alexandra Shingina, Monika Sarkar, Lauren Feld
Abstract not available
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Depression and anxiety in inflammatory bowel disease: epidemiology, mechanisms and treatment Nat. Rev. Gastroenterol. Hepatol. (IF 46.802) Pub Date : 2022-06-22 Tania H. Bisgaard, Kristine H. Allin, Laurie Keefer, Ashwin N. Ananthakrishnan, Tine Jess
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Association of Statin Usage and the Development of Diabetes Mellitus after Acute Pancreatitis. Clin. Gastroenterol. Hepatol. (IF 11.382) Pub Date : 2022-06-21 Nikhil R. Thiruvengadam, Douglas E. Schaubel, Kimberly Forde, Peter Lee, Monica Saumoy, Michael L. Kochman
Background Patients with Acute Pancreatitis (AP) have at least a two-fold higher risk for developing post-pancreatitis diabetes mellitus (PPDM). No therapies have prevented PPDM. Statins were demonstrated to possibly lower the incidence and severity of AP but have not been studied to prevent PPDM. Methods Data from a commercial insurance claim database (Optum Clinformatics) was used to assess the impact
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Hepatic events associated with sodium-glucose cotransporter-2 inhibitors in patients with type 2 diabetes: a nationwide cohort study Gut (IF 23.059) Pub Date : 2022-06-20 Sungho Bea, Han Eol Jeong, Sohee Park, Oriana H Y Yu, Yoosoo Chang, Juhee Cho, Dong Hyun Sinn, Young Min Cho, Ju-Young Shin
We read with great interest the report on risk of incident diabetes mellitus among patients with non-alcoholic fatty liver disease by Mantovani et al .1 The bidirectional relationship between type 2 diabetes (T2D) and liver disease has been largely evaluated.2–4 However, optimal therapeutic options for T2D in patients with metabolic syndrome remain unclear. Several randomised trials have shown that
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Kyoto international consensus report on anatomy, pathophysiology and clinical significance of the gastro-oesophageal junction Gut (IF 23.059) Pub Date : 2022-06-20 Kentaro Sugano, Stuart Jon Spechler, Emad M El-Omar, Kenneth E L McColl, Kaiyo Takubo, Takuji Gotoda, Mitsuhiro Fujishiro, Katsunori Iijima, Haruhiro Inoue, Takashi Kawai, Yoshikazu Kinoshita, Hiroto Miwa, Ken-ichi Mukaisho, Kazunari Murakami, Yasuyuki Seto, Hisao Tajiri, Shobna Bhatia, Myung-Gyu Choi, Rebecca C Fitzgerald, Kwong Ming Fock, Khean-Lee Goh, Khek Yu Ho, Varocha Mahachai, Maria O'Donovan
Objective An international meeting was organised to develop consensus on (1) the landmarks to define the gastro-oesophageal junction (GOJ), (2) the occurrence and pathophysiological significance of the cardiac gland, (3) the definition of the gastro-oesophageal junctional zone (GOJZ) and (4) the causes of inflammation, metaplasia and neoplasia occurring in the GOJZ. Design Clinical questions relevant
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Global, regional, and national burden of hepatitis B, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019 Gastroenterol. Hepatol. (IF 18.486) Pub Date : 2022-06-21
Background Combating viral hepatitis is part of the UN Sustainable Development Goals (SDGs), and WHO has put forth hepatitis B elimination targets in its Global Health Sector Strategy on Viral Hepatitis (WHO-GHSS) and Interim Guidance for Country Validation of Viral Hepatitis Elimination (WHO Interim Guidance). We estimated the global, regional, and national prevalence of hepatitis B virus (HBV), as
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What Is the Prevalence of Clinically Significant Endoscopic Findings in Subjects with Dyspepsia? Updated Systematic Review and Meta-analysis Clin. Gastroenterol. Hepatol. (IF 11.382) Pub Date : 2022-06-20 Siavosh Nasseri-Moghaddam, Amir-Hossein Mousavian, Amir Kasaeian, Takeshi Kanno, Yuhong Yuan, Alex C. Ford, Paul Moayyedi
BACKGROUND & AIMS The prevalence of clinically significant endoscopic findings in people with dyspepsia and understanding how symptoms can predict endoscopic pathology can help inform dyspepsia guidelines. We evaluated this in an updated systematic review and meta-analysis. METHODS We searched MEDLINE, EMBASE and Cochrane CENTRAL and the Cochrane Database of Systematic Reviews from 2010 through to
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Exhaustion of CD39-expressing CD8+ T cells in Crohn’s disease is linked to clinical outcome Gastroenterology (IF 22.682) Pub Date : 2022-06-20 Anna-Maria Globig, Lena Sophie Mayer, Maximilian Heeg, Geoffroy Andrieux, Manching Ku, Patricia Otto-Mora, Anna Hipp, Katharina Zoldan, Ajinkya Pattekar, Nisha Rana, Christoph Schell, Melanie Boerries, Maike Hofmann, Christoph Neumann-Haefelin, Armin Kuellmer, Arthur Schmidt, Tobias Boettler, Vesselin Tomov, Bertram Bengsch
Background and Aims Exhaustion of CD8 T cells has been suggested to inform different clinical outcomes in Crohn’s disease (CD) but detailed analyses are lacking. This study aimed to identify the role of exhaustion on a single-cell level and identify relevant CD8 T cell populations in CD. Methods Blood and intestinal tissue from 58 CD patients (active disease or remission) were assessed for CD8 T cell
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Elsewhere in The AGA Journals Gastroenterology (IF 22.682) Pub Date : 2022-06-20
Abstract not available
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AGA Clinical Practice Guideline on the Pharmacological Management of Irritable Bowel Syndrome With Constipation Gastroenterology (IF 22.682) Pub Date : 2022-06-20 Lin Chang, Shahnaz Sultan, Anthony Lembo, G. Nicholas Verne, Walter Smalley, Joel J. Heidelbaugh
Background & Aims Irritable bowel syndrome (IBS) is a common disorder of gut–brain interaction associated with significant disease burden. This American Gastroenterological Association guideline is intended to support practitioners in decisions about the use of medications for the pharmacological management of IBS-C and is an update of a prior technical review and guideline. Methods The Grading of
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AGA Clinical Practice Guideline on the Pharmacological Management of Irritable Bowel Syndrome With Diarrhea Gastroenterology (IF 22.682) Pub Date : 2022-06-20 Anthony Lembo, Shahnaz Sultan, Lin Chang, Joel J. Heidelbaugh, Walter Smalley, G. Nicholas Verne
Background & Aims Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder associated with significant disease burden. This American Gastroenterological Association Guideline is intended to support practitioners in decisions about the use of medications for the pharmacological management of IBS with predominant diarrhea (IBS-D) and is an update of a prior technical review and
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Clinical Decision Support Tool: IBS Treatment Gastroenterology (IF 22.682) Pub Date : 2022-06-20
Abstract not available
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Spotlight: IBS Treatment Gastroenterology (IF 22.682) Pub Date : 2022-06-20 Lin Chang, Anthony Lembo, Shahnaz Sultan
Abstract not available
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CME Exam 1: American Gastroenterological Association Clinical Practice Guidelines on the Pharmacological Management of Irritable Bowel Syndrome with Constipation (IBS-C) and American Gastroenterological Association Clinical Practice Guidelines on the Pharmacological Management of Irritable Bowel Syndrome with Diarrhea (IBS-D) Gastroenterology (IF 22.682) Pub Date : 2022-06-20
Abstract not available
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A retrospective cohort study: pre-operative oral enteral nutritional optimisation for Crohnʼs disease in a UK tertiary IBD Centre Aliment. Pharm. Ther. (IF 8.171) Pub Date : 2022-06-20 Susanna Meade, Kamal V. Patel, Raphael P. Luber, Dearbhaile O'Hanlon, Andra Caracostea, Polychronis Pavlidis, Sailish Honap, Cheran Anandarajah, Nyree Gryffin, Sebastian Zeki, Shuvra Ray, Joel Mawdsley, Mark A. Samaan, Simon H. Anderson, Amir Darakhshan, Katie Adams, Andrew Williams, Jeremy D. Sanderson, Miranda Lomer, Peter M. Irving
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Salivary microbiota composition may discriminate between patients with eosinophilic oesophagitis (EoE) and non-EoE subjects Aliment. Pharm. Ther. (IF 8.171) Pub Date : 2022-06-17 Sonia Facchin, Matteo Calgaro, Mattia Pandolfo, Federico Caldart, Matteo Ghisa, Eliana Greco, Eleonora Sattin, Giorgio Valle, Evan Dellon, Nicola Vitulo, Edoardo Vincenzo Savarino
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Counting calories, hours or both: Is time-restricting eating efficient for weight loss? Gastroenterology (IF 22.682) Pub Date : 2022-06-20 Marianna Arvanitakis
Abstract not available
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The Utility of Esophageal Transit Scintigraphy in the Diagnosis of Dysphagia Lusoria Gastrointest. Endosc. (IF 9.427) Pub Date : 2022-06-18 June Tome, Amrit K. Kamboj, Cadman L. Leggett
Abstract not available
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Endoscopic mucosal resection combined with hybrid argon plasma coagulation to prevent recurrence of large nonpedunculated colorectal polyps Gastrointest. Endosc. (IF 9.427) Pub Date : 2022-06-18 Leslie Motchum, John M. Levenick, Roupen Djinbachian, Matthew T. Moyer, Simon Bouchard, Mahsa Taghiakbari, Alessandro Repici, Erik Deslandres, Daniel von Renteln
Background and Aims Endoscopic mucosal resection (EMR) is the mainstay of therapy for large colorectal polyps. Local recurrence after EMR is common and can be reduced using margin ablation. Our aim was to evaluate recurrence rates when using hybrid argon plasma coagulation - HybridAPC® (h-APC) -ablation after EMR. Methods Adult patients (18–89 years) undergoing EMR of nonpedunculated colorectal polyps
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Biopsy channel of the endoscope as a potential source of infectious droplets during gastrointestinal endoscopy Gastrointest. Endosc. (IF 9.427) Pub Date : 2022-06-18 Mark F. Coughlan, Mandeep S. Sawhney, Douglas K. Pleskow, Umar Khan, Andy Silva-Santisteban, Awais Ahmed, Xuejun Zhang, Maria Glyavina, Liming Chen, Paul K. Upputuri, Yuri N. Zakharov, Lei Zhang, Le Qiu, Lev T. Perelman
Background and aims During endoscopy, droplets with the potential to transmit COVID-19 are known to emanate from a patient’s mouth and anus, but they may also be expelled from the biopsy channel of the endoscope. The main goal of our study was to quantify droplets emerging from the biopsy channel during clinical endoscopy. Methods A novel light scattering device was used to measure droplets emanating
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Endoscopic Resection of Upper Gastrointestinal Extraluminal Tumors Gastrointest. Endosc. (IF 9.427) Pub Date : 2022-06-18 Li-Yun Ma, Zu-Qiang Liu, Lu Yao, Mei-Dong Xu, Shi-Yao Chen, Yun-Shi Zhong, Yi-Qun Zhang, Wei-Feng Chen, Li-Li Ma, Wen-Zheng Qin, Jian-Wei Hu, Ming-Yan Cai, Li-Qing Yao, Quan-Lin Li, Ping-Hong Zhou
Background and Aims Endoscopic resection is a feasible treatment for gastrointestinal extraluminal tumors, but remains a challenging procedure with limited data. In this study, we assessed the safety and efficacy of endoscopic resection for extraluminal tumors in the upper gastrointestinal tract. Methods From May 2016 to December 2021, 109 patients undergoing endoscopic resection for extraluminal tumors
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Comparison of focal cryoballoon ablation with 10 and 8 second dose for treatment of Barrett’s esophagus related neoplasia: results from a prospective European multicenter study Gastrointest. Endosc. (IF 9.427) Pub Date : 2022-06-18 Charlotte N. Frederiks, Anouk Overwater, Lorenza Alvarez Herrero, Alaa Alkhalaf, Boudewijn E. Schenk, Alessandro Repici, Jacques J.G.H.M. Bergman, Roos E. Pouw, Raf Bisschops, Rehan J. Haidry, Torsten Beyna, Horst Neuhaus, Bas L.A.M. Weusten
Background and aims Focal cryoballoon ablation (FCBA) is currently investigated for the treatment of Barrett’s esophagus (BE) related neoplasia in a European multicenter study (Euro-Coldplay study). After inclusion of 28/107 patients, the initial dose of 10 seconds (s) was lowered to 8s. The current study aimed to compare the efficacy and safety of a single FCBA treatment session with 10s versus 8s
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Implementation of optical diagnosis with a ‘resect and discard strategy’ in clinical practice: DISCARD3 study Gastrointest. Endosc. (IF 9.427) Pub Date : 2022-06-18 Ahmir Ahmad, Morgan Moorghen, Ana Wilson, Ioannis Stasinos, Adam Haycock, Adam Humphries, Kevin Monahan, Noriko Suzuki, Siwan Thomas-Gibson, Margaret Vance, Kowshika Thiruvilangam, Angad Dhillon, Brian P. Saunders
Background and Aims Optical diagnosis (OD) of polyps can be performed with advanced endoscopic imaging. For high confidence diagnoses, a “resect and discard” strategy could offer significant histopathology time and cost savings. The implementation threshold is a ≥90% OD-histology surveillance interval concordance. Aims: assess OD learning curve and feasibility of “resect and discard” strategy for ≤5mm
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No Tube Left Behind: Feeding Tube Failure and Endoscopic Retrieval Gastrointest. Endosc. (IF 9.427) Pub Date : 2022-06-18 Alexander H. Yang, Melissa Abel, Anita J. Stokes, Theo Heller, Scott M. Norberg, Louis Y. Korman
Abstract not available
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Development of a Deep Learning Model for the Histological Diagnosis of Dysplasia in Barrett’s Esophagus Gastrointest. Endosc. (IF 9.427) Pub Date : 2022-06-17 Shahriar Faghani, D. Chamil Codipilly, David Vogelsang, Mana Moassefi, Pouria Rouzrokh, Bardia Khosravi, Siddharth Agarwal, Lovekirat Dhaliwal, David A. Katzka, Catherine Hagen, Jason Lewis, Cadman L. Leggett, Bradley J. Erickson, Prasad G. Iyer
Background and aims The risk of progression in Barrett’s esophagus (BE) increases with development of dysplasia. There is a critical need to improve the diagnosis of BE dysplasia, given substantial interobserver disagreement among expert pathologists and overcalls of dysplasia by community pathologists. We developed a deep learning model to predict dysplasia grade on whole slide imaging. Methods We
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Environmental and Health Outcomes of Single-Use versus Reusable Duodenoscopes Gastrointest. Endosc. (IF 9.427) Pub Date : 2022-06-17 Nguyen Nhat Thu Le, Lyndon Hernandez, Nimish Vakil, Nalini Guda, Casey Patnode, Olivier Jolliet
Background and Aims The large-scale effects of duodenoscopes on the environment and public health have not been quantified. Our aim was to perform an exploratory Life Cycle Assessment (LCA) comparing environmental and human health effects of single-use (SD) and reusable duodenoscopes (RD). Methods We evaluated three duodenoscopes: 1) conventional RD; 2) RD with disposable endcaps; and 3) SD. The primary
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Bacterial contamination and organic residue after reprocessing in duodenoscopes with disposable distal caps compared to duodenoscopes with fixed distal caps: a randomized trial Gastrointest. Endosc. (IF 9.427) Pub Date : 2022-06-17 Wiriyaporn Ridtitid, Tiwaporn Thummongkol, Tanittha Chatsuwan, Panida Piyachaturawat, Santi Kulpatcharapong, Phonthep Angsuwatcharakon, Parit Mekaroonkamol, Pradermchai Kongkam, Rungsun Rerknimitr
Background and Aims Newly designed duodenoscopes with disposable distal caps have been developed for better cleaning and preprocessing to reduce the risk of bacterial contamination (BC). We compared BC and organic residue of duodenoscopes with disposable distal caps and duodenoscopes with fixed distal caps after manual cleaning and high-level disinfection (HLD). Methods 400 duodenoscopes were randomized
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New global strategies for HIV, viral hepatitis, and STIs Gastroenterol. Hepatol. (IF 18.486) Pub Date : 2022-06-17 Udani Samarasekera
Abstract not available
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Use of cidofovir in recent outbreak of adenovirus-associated acute liver failure in children Gastroenterol. Hepatol. (IF 18.486) Pub Date : 2022-06-17 Anita Verma, Sunitha Vimalesvaran, Temi Lampejo, Akash Deep, Anil Dhawan
Abstract not available
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Hemostatic Powder Monotherapy in the Initial Endoscopic Treatment of Nonvariceal Upper Gastrointestinal Bleeding Gastroenterology (IF 22.682) Pub Date : 2022-06-18 Nauzer Forbes
Abstract not available
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A Rare Complication of Percutaneous Transhepatic Gallbladder Drainage Gastroenterology (IF 22.682) Pub Date : 2022-06-18 Yang-Yuan Chen, Chih-Hsuan Chen, Yung-Fang Chen
Abstract not available
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Incidental Finding During Colonoscopy Gastroenterology (IF 22.682) Pub Date : 2022-06-18 John Hanson, Kyle Kreitman, Leonard Baidoo
Abstract not available
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Environmental protective and risk factors in an at-risk population of subsequent Crohn’s Disease Gastroenterology (IF 22.682) Pub Date : 2022-06-18 Daniele Noviello, Federica Facciotti, Flavio Caprioli
Abstract not available
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Recent Advances in the Study of Extracellular Vesicles in Colorectal Cancer Gastroenterology (IF 22.682) Pub Date : 2022-06-18 Sarah E. Glass, Robert J. Coffey
There has been significant progress in the study of extracellular vesicles (EVs) since the 2017 American Gastroenterological Association-sponsored Freston conference Extracellular Vesicles: Biology, Translation and Clinical Application in GI Disorders. The burgeoning interest in this field stems from the increasing recognition that EVs represent an understudied form of cell-to-cell communication and
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Disrupting polarized trafficking in intestinal epithelial cells: Insights from a novel congenital enteropathy gene. Gastroenterology (IF 22.682) Pub Date : 2022-06-18 Jay R. Thiagarajah
Abstract not available
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A Rare Cause Of Chronic Abdominal Pain And Weight Loss Gastroenterology (IF 22.682) Pub Date : 2022-06-18 Sih-Ruei Chen, Ming-Chang Tsai, Chi-Chih Wang
Abstract not available
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Novel hot and cold spots of young-onset colorectal cancer mortality in United States counties Gastroenterology (IF 22.682) Pub Date : 2022-06-18 R. Blake Buchalter, Suneel D. Kamath, Kanika G. Nair, David Liska, Alok A. Khorana, Stephanie L. Schmit
Abstract not available
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Potential effects of FGFR4 in the Helicobacter pylori-induced inflammatory carcinoma transformation Gastroenterology (IF 22.682) Pub Date : 2022-06-18 Yanfei Jia, Zhiming Lu, Duanrui Liu
Abstract not available
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Altered mycobiota signatures and enriched pathogenic Aspergillus rambellii are associated with colorectal cancer based on multi-cohort fecal metagenomic analyses Gastroenterology (IF 22.682) Pub Date : 2022-06-18 Yufeng Lin, Harry Cheuk-Hay Lau, Yali Liu, Xing Kang, Yiwei Wang, Nick Lung-Ngai Ting, Thomas Ngai-Yeung Kwong, Jing Han, Weixin Liu, Changan Liu, Junjun She, Sunny Hei Wong, Joseph Jao-Yiu Sung, Jun Yu
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Ketogenic diet as a chemopreventative and therapeutic strategy for colon cancer. Gastroenterology (IF 22.682) Pub Date : 2022-06-18 David J. Pinato
Abstract not available
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Esophageal grape-like lesion in a 41-year-old man with a history of gastroesophageal junction adenocarcinoma Gastroenterology (IF 22.682) Pub Date : 2022-06-18 Puo-Hsien Le, Yung-Kuan Tsou, Ren-Chin Wu
Abstract not available