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‘I have to remind myself that everyone’s search is different’: experiences and outcomes of searching and not searching for donor connections among donor conceived adults Hum. Reprod. (IF 6.0) Pub Date : 2024-09-17 S Zadeh, C Jones, V Jadva
STUDY QUESTION What are the experiences and outcomes of donor conceived adults who are actively searching for, open to contact with, or not searching for donor connections? SUMMARY ANSWER Most participants were actively searching or open to contact, and 67% had found or been found by a connection; finding or not finding experiences were complex. WHAT IS KNOWN ALREADY There is variation among donor
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Embryonic size and growth and adverse birth outcomes: the Rotterdam Periconception Cohort Hum. Reprod. (IF 6.0) Pub Date : 2024-09-17 J A Roelants, M J Vermeulen, S P Willemsen, J V Been, A H Koning, A J Eggink, K F M Joosten, I K M Reiss, R P M Steegers-Theunissen
STUDY QUESTION Is early embryonic size and growth in the first trimester of pregnancy associated with adverse birth outcomes? SUMMARY ANSWER Larger embryonic crown–rump length (CRL) and embryonic volume (EV) are associated with lower odds of adverse birth outcomes, especially small for gestational age (SGA). WHAT IS ALREADY KNOWN Preterm birth, SGA, and congenital anomalies are the most prevalent adverse
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EuMAR stakeholder engagement: an analysis of medically assisted reproduction (MAR) data collection practices in EU countries Hum. Reprod. (IF 6.0) Pub Date : 2024-09-14 Elena Achótegui Sebastián, Carlos Calhaz-Jorge, Christian De Geyter, Thomas Ebner, Carlos E Plancha, Veerle Goossens, Anja Pinborg, Nikolaos P Polyzos, Laura Rossignoli, Ioana Adina Rugescu, Jesper Smeenk, Thomas Strowitzki, Johanna Tassot, Edgar V Mocanu, Nathalie Vermeulen, Christine Wyns, M Cristina Magli
STUDY QUESTION What are the current national medically assisted reproduction (MAR) data collection systems across EU Member States, and how can these countries contribute to a unique, cycle-by-cycle registry for the European Monitoring of Medically Assisted Reproduction (EuMAR) project? SUMMARY ANSWER The study identified significant variation in MAR data collection practices across Member States,
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Reply: Sticking to the facts instead of speculating: evidence against intensive luteal phase support in endometriosis patients undergoing HRT-FET cycles. Hum. Reprod. (IF 6.0) Pub Date : 2024-09-13 C Maignien,M Bourdon,C Chapron,P Santulli
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Permanently infertile couples and family building-a cross-sectional survey in Denmark. Hum. Reprod. (IF 6.0) Pub Date : 2024-09-13 M Tanderup,D Vassard,B B Nielsen,A Pande,C Kroløkke,P Humaidan,L Schmidt
STUDY QUESTION Which decision-making factors influence family building among permanently infertile couples? SUMMARY ANSWER Ethical, legal, and financial considerations outweigh genetic relatedness in decision-making, favouring domestic gestational surrogacy, if this were possible, over international options. WHAT IS KNOWN ALREADY Permanent infertility affects 4-5% of people in the fertile age. Their
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The experience of transfeminine adolescents and their parents regarding fertility preservation via testicular sperm extraction (TESE): a qualitative study. Hum. Reprod. (IF 6.0) Pub Date : 2024-09-13 T H R Stolk,N M van Mello,A Meißner,J A F Huirne,E van den Boogaard
STUDY QUESTION How do transfeminine adolescents and their parents experience fertility preservation via testicular sperm extraction (TESE)? SUMMARY ANSWER Participants experienced the TESE process positively when provided with appropriate guidance to navigate the decisional dilemma between preserving future biological parenthood and the pressure to start puberty suppression early. WHAT IS KNOWN ALREADY
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The devil lies in the detail-the role of intensive exogenous progesterone supplementation in the endometriosis patient undergoing HRT-FET. Hum. Reprod. (IF 6.0) Pub Date : 2024-09-13 P Humaidan,B Alsbjerg
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Assessment of male creatinine levels and fecundity in couples planning pregnancy: a national cohort study in China. Hum. Reprod. (IF 6.0) Pub Date : 2024-09-12 Yan Xuan,Jun Zhao,Xiang Hong,Yue Zhang,Rong Zhang,Hongguang Zhang,Tao Yan,Yuanyuan Wang,Zuoqi Peng,Ya Zhang,Kailei Jiao,Qiaomei Wang,Haiping Shen,Yiping Zhang,Donghai Yan,Xu Ma,Bei Wang
STUDY QUESTION Is there an association between male creatinine levels and time to pregnancy (TTP) in couples planning pregnancy? SUMMARY ANSWER Low and high male creatinine concentrations were associated with reduced couple fecundity. WHAT IS KNOWN ALREADY Abundant evidence suggests male creatinine dysfunction is associated with infertility in males with kidney diseases. However, the association of
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Semen analysis and reproductive hormones in boys with classical Hodgkin lymphoma treated according to the EuroNet-PHL-C2 protocol Hum. Reprod. (IF 6.0) Pub Date : 2024-09-11 K C E Drechsel, S L Broer, H M K van Breda, F S Stoutjesdijk, E van Dulmen-den Broeder, A Beishuizen, W H Wallace, D Körholz, C Mauz-Körholz, D Hasenclever, M Cepelova, A Uyttebroeck, L Ronceray, J W R Twisk, G J L Kaspers, M A Veening
STUDY QUESTION What is the impact of the EuroNet-PHL-C2 treatment for boys with classical Hodgkin lymphoma (cHL) on semen parameters? SUMMARY ANSWER More than half of the patients (52%, n = 16/31) had oligozoospermia or azoospermia at 2 years from cHL diagnosis; particularly boys treated for advanced-stage cHL had low sperm counts and motility. WHAT IS KNOWN ALREADY Chemotherapy and radiotherapy to
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Single-cell RNA sequencing reveals transcriptomic landscape and potential targets for human testicular ageing Hum. Reprod. (IF 6.0) Pub Date : 2024-09-07 Kai Xia, Peng Luo, Jiajie Yu, Siyuan He, Lin Dong, Feng Gao, Xuren Chen, Yunlin Ye, Yong Gao, Yuanchen Ma, Cuifeng Yang, Yadong Zhang, Qiyun Yang, Dayu Han, Xin Feng, Zi Wan, Hongcai Cai, Qiong Ke, Tao Wang, Weiqiang Li, Xiang’an Tu, Xiangzhou Sun, Chunhua Deng, Andy Peng Xiang
STUDY QUESTION What is the molecular landscape underlying the functional decline of human testicular ageing? SUMMARY ANSWER The present study provides a comprehensive single-cell transcriptomic atlas of testes from young and old humans and offers insights into the molecular mechanisms and potential targets for human testicular ageing. WHAT IS KNOWN ALREADY Testicular ageing is known to cause male age-related
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Livebirth rates are influenced by an interaction between male and female partners’ age: analysis of 59 951 fresh IVF/ICSI cycles with and without male infertility Hum. Reprod. (IF 6.0) Pub Date : 2024-09-07 A K Datta, S Campbell, R Diaz-Fernandez, G Nargund
STUDY QUESTION Does advanced male partner’s age impact live birth rates (LBRs) in IVF treatment when female partner’s age is factored in? SUMMARY ANSWER In fresh IVF cycles LBRs decline with male partner’s age ≥40 years when the female partner is aged 35–39 years, irrespective of the presence or absence of male factor; but not when the female partner is <35 years or ≥40 years of age; this decline is
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Psychological characteristics and structural brain changes in women with endometriosis and endometriosis-independent chronic pelvic pain Hum. Reprod. (IF 6.0) Pub Date : 2024-09-07 L Maulitz, S Nehls, E Stickeler, A Ignatov, T Kupec, A T Henn, N Chechko, S N Tchaikovski
STUDY QUESTION Are there neurobiological changes induced by endometriosis? SUMMARY ANSWER Women with endometriosis demonstrate specific neurobiological changes distinct from those in patients with chronic pelvic pain (CPP) in the absence of endometriosis. WHAT IS KNOWN ALREADY Endometriosis is a chronic disease affecting women of reproductive age that presents with pain and infertility often accompanied
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Clinical pregnancy rates after blastocyst culture at a stable temperature of 36.6°C versus 37.1°C: a prospective randomized controlled trial Hum. Reprod. (IF 6.0) Pub Date : 2024-09-07 Koen Wouters, Ileana Mateizel, Ingrid Segers, Hilde Van de Velde, Lisbet Van Landuyt, Anick De Vos, Celine Schoemans, Danijel Jankovic, Christophe Blockeel, Panagiotis Drakopoulos, Herman Tournaye, Neelke De Munck
STUDY QUESTION Is there a difference in clinical pregnancy rates (CPRs) in good prognosis patients after single embryo transfer (SET) on Day 5, in case of stable culture at 36.6°C or 37.1°C? SUMMARY ANSWER CPR (with heartbeat at 7 weeks) after blastocyst transfer do not differ after culturing at 36.6°C or 37.1°C. WHAT IS KNOWN ALREADY Since the beginning of IVF, embryo culture has been performed at
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Optimized personalized management approach for moderate/severe OHSS: development and prospective validation of an OHSS risk assessment index. Hum. Reprod. (IF 6.0) Pub Date : 2024-09-05 Mingzhu Cao,Qiwang Lin,Zhi Liu,Yanshan Lin,Qing Huang,Yang Fu,Yang Zhang,Hang Shi,Chongyang Duan,Haiying Liu,Jianqiao Liu
STUDY QUESTION Can a simplified ovarian hyperstimulation syndrome (OHSS) risk assessment index be developed and validated with sufficient discrimination of moderate/severe OHSS from those without OHSS? SUMMARY ANSWER This easy-to-use OHSS risk assessment index shows good discriminative power and high calibration accuracy in internal and external validation cohorts. WHAT IS KNOWN ALREADY An early alert
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CALR3 defects disrupt sperm-zona pellucida binding in humans: new insights into male factor fertilization failure and relevant clinical therapeutic approaches. Hum. Reprod. (IF 6.0) Pub Date : 2024-09-05 Yang Gao,Rufeng Xue,Rui Guo,Fan Yang,Xuan Sha,Yuqian Li,Rong Hua,Guotong Li,Qunshan Shen,Kuokuo Li,Wenwen Liu,Yuping Xu,Ping Zhou,Zhaolian Wei,Zhiguo Zhang,Yunxia Cao,Xiaojin He,Huan Wu
STUDY QUESTION Do biallelic deleterious variants of Calreticulin 3 (CALR3) cause fertilization failure (FF), resulting in male infertility in humans? SUMMARY ANSWER Biallelic mutations in CALR3 were identified in two infertile men from unrelated families and were shown to cause FF associated with failed sperm-zona pellucida (ZP) binding. WHAT IS KNOWN ALREADY In male mice, the Calr3-knockout has been
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Long-term culture of human Sertoli cells from adult Klinefelter patients as a first step to develop new tools for unravelling the testicular physiopathology. Hum. Reprod. (IF 6.0) Pub Date : 2024-09-05 Maria Grazia Giudice,Marc Kanbar,Jonathan Poels,Armelle Duquenne,Christine Wyns
STUDY QUESTION Are Sertoli cells (SCs) from adult Klinefelter men (47,XXY) capable of proliferating in vitro and maintaining their main phenotypical and functional characteristics as do SCs from adult 46,XY patients? SUMMARY ANSWER Isolated SCs from patients with Klinefelter syndrome (KS) can be expanded in vitro while maintaining their characteristics and a stable karyotype, similar to SCs from 46
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Biallelic RXFP2 variants lead to congenital bilateral cryptorchidism and male infertility, supporting a role of RXFP2 in spermatogenesis. Hum. Reprod. (IF 6.0) Pub Date : 2024-09-02 Hannes Syryn,Julie Van de Velde,Griet De Clercq,Hannah Verdin,Annelies Dheedene,Frank Peelman,Andrew Sinclair,Katie L Ayers,Ross A D Bathgate,Martine Cools,Elfride De Baere
STUDY QUESTION Does RXFP2 disruption impair male fertility? SUMMARY ANSWER We identified biallelic variants in RXFP2 in patients with male infertility due to spermatogenic arrest at the spermatid stage, supporting a role of RXFP2 in human spermatogenesis, specifically in germ cell maturation. WHAT IS KNOWN ALREADY Since RXFP2, the receptor for INSL3, plays a crucial role in testicular descent during
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No pain relief by virtual reality during hysterosalpingography (HSG): results from a randomized controlled trial. Hum. Reprod. (IF 6.0) Pub Date : 2024-09-01 K Rosielle,A P van Haaps,E A M Kuijper,N Tonch,D E N B Karim,M A Oskam,R van den IJssel,B W J Mol,C B Lambalk,K Dreyer,V Mijatovic
STUDY QUESTION Is virtual reality (VR) an effective non-pharmacological tool to reduce procedural pain during hysterosalpingography (HSG)? SUMMARY ANSWER An HSG with VR does not reduce procedural pain scores compared to an HSG without VR. WHAT IS KNOWN ALREADY An HSG is often experienced as painful and uncomfortable. VR has been proven successful to reduce acute procedural pain during a variety of
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Association between parity and female mortality: the mediative role of depressive symptoms Hum. Reprod. (IF 6.0) Pub Date : 2024-08-30 Zhimin Deng, Yiqiu Wei, Fangfang Dai, Dongyong Yang, Dongdong Tang, Jue Liu, Tailang Yin
STUDY QUESTION Is parity associated with all-cause and cause-specific mortality among women in a nationally representative cohort of the US population, and does depression mediate this association? SUMMARY ANSWER Nulliparous women have a higher risk of all-cause and cause-specific mortality, with depression partially mediating the relationship between parity and women’s all-cause and cause-specific
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Neurodevelopmental outcomes of school-age children conceived after hysterosalpingography with oil-based or water-based iodinated contrast: long-term follow-up of a nationwide randomized controlled trial Hum. Reprod. (IF 6.0) Pub Date : 2024-08-29 Sarai M Keestra, Nienke Van Welie, Kim Dreyer, Rik Van Eekelen, Tessa J Roseboom, Jaap Oosterlaan, Ben W Mol, Martijn J J Finken, Velja Mijatovic, Marsh Königs
STUDY QUESTION Does preconceptional exposure to oil-based iodinated contrast media during hysterosalpingography (HSG) impact children’s neurodevelopment compared with exposure to water-based alternatives? SUMMARY ANSWER Our study found no large-sized effects for neurodevelopment in children with preconceptional exposure to oil-based iodinated contrast media during HSG compared with water-based alternatives
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Empowering nurses and midwives: the evidence-base for the Nurses and Midwives Certification Programme of ESHRE Hum. Reprod. (IF 6.0) Pub Date : 2024-08-29 S Somers, H Cotton, H Kendrew, J Pomper, A Pinborg, I R Jorgensen, C Plas, E H Hanenberg, V L Peddie, E A F Dancet
STUDY QUESTION How were the logbook and curriculum for the Nurses and Midwives Certification Programme of ESHRE developed? SUMMARY ANSWER The logbook and corresponding curriculum for the ESHRE Nurses and Midwives Certification Programme were based on an extensive literature review, an international expert panel, and a survey of Belgian and Dutch nurses and midwives (N&M) working in reproductive medicine
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Trophectoderm grade is associated with the risk of placenta previa in frozen-thawed single-blastocyst transfer cycles Hum. Reprod. (IF 6.0) Pub Date : 2024-08-29 Jiaan Huang, Yao Lu, Yaqiong He, Yuan Wang, Qinling Zhu, Jia Qi, Ying Ding, Xinyu Li, Ziyin Ding, Steven R Lindheim, Yun Sun
STUDY QUESTION Do obstetric and perinatal complications vary according to different blastocyst developmental parameters after frozen-thawed single-blastocyst transfer (SBT) cycles? SUMMARY ANSWER Pregnancies following the transfer of a blastocyst with a grade C trophectoderm (TE) were associated with an increased risk of placenta previa compared to those with a blastocyst of grade A TE. WHAT IS KNOWN
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Testicular mosaicism in non-mosaic postpubertal Klinefelter patients with focal spermatogenesis and in non-mosaic prepubertal Klinefelter boys Hum. Reprod. (IF 6.0) Pub Date : 2024-08-29 Semir Gül, Veerle Vloeberghs, Inge Gies, Ellen Goossens
STUDY QUESTION Do testis-specific cells have a normal karyotype in non-mosaic postpubertal Klinefelter syndrome (KS) patients with focal spermatogenesis and in non-mosaic prepubertal KS boys? SUMMARY ANSWER Spermatogonia have a 46, XY karyotype, and Sertoli cells surrounding these spermatogonia in postpubertal patients also have a 46, XY karyotype, whereas, in prepubertal KS boys, Sertoli cells surrounding
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Comparison of embryologist stress, somatization, and burnout reported by embryologists working in UK HFEA-licensed ART/IVF clinics and USA ART/IVF clinics Hum. Reprod. (IF 6.0) Pub Date : 2024-08-29 Anar Murphy, Mark S Lapczynski, Glenn Proctor, Timothy R Glynn, Alice D Domar, Sofia Gameiro, Giles A Palmer, Michael G Collins
STUDY QUESTION What is the prevalence of occupational stress, somatization, and burnout reported by UK and US, embryologists and the impact of work conditions on these well-being outcomes? SUMMARY ANSWER Surveyed UK and US embryologists reported moderate perceived stress, low somatic symptom severity, high levels of burnout, and overall stressful work conditions, but with differences that could be
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The effect of prior hysterosalpingo-foam sonography or hysterosalpingography on tubal patency: a secondary analysis of a randomized controlled trial. Hum. Reprod. (IF 6.0) Pub Date : 2024-08-27 Danah Kamphuis,Nienke van Welie,Joukje van Rijswijk,Marcel H A van Hooff,Jan-Peter de Bruin,Harold R Verhoeve,Femke Mol,Wilhelmina M van Baal,Cornelis B Lambalk,Jaap Stoker,Madelon van Wely,Patrick M M Bossuyt,Ben Willem J Mol,Kim Dreyer,Velja Mijatovic,
STUDY QUESTION Does hysterosalpingo-foam sonography (HyFoSy) prior to hysterosalpingography (HSG) or HSG prior to HyFoSy affect visible tubal patency when compared HSG or HyFoSy alone? SUMMARY ANSWER Undergoing either HyFoSy or HSG prior to tubal patency testing by the alternative method does not demonstrate a significant difference in visible tubal patency when compared to HyFoSy or HSG alone. WHAT
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Distribution of endometriosis phenotypes according to patients’ age in adult women with surgical evaluation Hum. Reprod. (IF 6.0) Pub Date : 2024-08-25 M Bourdon, C Maignien, L Marcellin, L Maitrot Mantelet, G Parpex, P Santulli, C Chapron
STUDY QUESTION What is the distribution of endometriosis phenotypes according to age in adult women undergoing surgery? SUMMARY ANSWER The phenotype of endometriosis did not significantly vary after 24 years old. WHAT IS KNOWN ALREADY The phenotypic evolution of endometriosis over time remains unclear. While adolescents can exhibit any type of endometriosis lesions, ovarian endometriosis (OMA) and/or
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Doppler ultrasound and first trimester pregnancy: not always a happy marriage. Hum. Reprod. (IF 6.0) Pub Date : 2024-08-24 Stefania Carlucci,Christoph Lees,Piero Miloro,Ioannis Papastefanou,Gail Ter Haar,Andrea Dall'Asta
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Reply: Doppler ultrasound and first trimester pregnancy: not always a happy marriage. Hum. Reprod. (IF 6.0) Pub Date : 2024-08-24 E S de Vos,A G M G J Mulders,A H J Koning,S P Willemsen,M Rousian,B B van Rijn,E A P Steegers,R P M Steegers-Theunissen
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Exposure of antral follicles to medroxyprogesterone acetate during stimulation does not cause molecular perturbations in gonadotropin-responsiveness and steroidogenic function of granulosa cells in progestin-primed cycles Hum. Reprod. (IF 6.0) Pub Date : 2024-08-24 Ozgur Oktem, Yashar Esmaeilian, Ece İltumur, Sevgi Yusufoglu, Deniz Uğurlu Çimen, Said Incir, Kayhan Yakin, Baris Ata, Bulent Urman
STUDY QUESTION Does medroxyprogesterone acetate (MPA) exposure in progestin-primed ovarian stimulation (PPOS) cycles cause molecular perturbations in the steroidogenic function and gonadotropin responsiveness of the granulosa cells? SUMMARY ANSWER PPOS cycles are identical to traditional GnRH antagonist cycles not only for clinical IVF characteristics but also for gonadotropin receptor expression,
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Protective effects of engineered Lactobacillus crispatus strains expressing G-CSF on thin endometrium of mice. Hum. Reprod. (IF 6.0) Pub Date : 2024-08-23 Shuang Liu,Yingnan Zhang,Xin Ma,Chenglin Zhan,Ning Ding,Mai Shi,Wei Zhang,Shubao Yang
STUDY QUESTION Does recombinant Lactobacillus expressing granulocyte colony-stimulating factor (G-CSF) have a better protective effect than the current treatment of thin endometrium (TE)? SUMMARY ANSWER This study suggested that the intrauterine injection of Lactobacillus crispastus (L. crispastus)-pPG612-G-CSF has a positive effect on preventing TE induced by 95% alcohol in mice. WHAT IS KNOWN ALREADY
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A nomogram and risk stratification to predict subsequent pregnancy loss in patients with recurrent pregnancy loss. Hum. Reprod. (IF 6.0) Pub Date : 2024-08-23 Mingyang Li,Renyi Zhou,Daier Yu,Dan Chen,Aimin Zhao
STUDY QUESTION Could the risk of subsequent pregnancy loss be predicted based on the risk factors of recurrent pregnancy loss (RPL) patients? SUMMARY ANSWER A nomogram, constructed from independent risk factors identified through multivariate logistic regression, serves as a reliable tool for predicting the likelihood of subsequent pregnancy loss in RPL patients. WHAT IS KNOWN ALREADY Approximately
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Reply. Recurrent implantation failure in patients undergoing euploid embryo transfers are unlikely to be caused by unmodifiable extra-embryonic factors. Hum. Reprod. (IF 6.0) Pub Date : 2024-08-22 Baris Ata,Pavan Gill,Danilo Cimadomo,Filippo Maria Ubaldi,Juan A Garcia-Velasco,Emre Seli
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Exploring the impact of fertility-preserving treatment on pregnancy: key issues in patients with endometrial cancer and atypical hyperplasia. Hum. Reprod. (IF 6.0) Pub Date : 2024-08-22 Wei-Zhen Tang,Tai-Hang Liu
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Development of an IVF prediction model for donor oocytes: a retrospective analysis of 10 877 embryo transfers. Hum. Reprod. (IF 6.0) Pub Date : 2024-08-22 Oisin Fitzgerald,Jade Newman,Luk Rombauts,Alex Polyakov,Georgina M Chambers
STUDY QUESTION Can we develop a prediction model for the chance of a live birth following the transfer of an embryo created using donated oocytes? SUMMARY ANSWER Three primary models that included patient, past treatment, and cycle characteristics were developed using Australian data to predict the chance of a live birth following the transfer of an embryo created using donated oocytes; these models
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Testing an artificial intelligence algorithm to predict fetal heartbeat of vitrified-warmed blastocysts from a single image: predictive ability in different settings. Hum. Reprod. (IF 6.0) Pub Date : 2024-08-22 L Conversa,L Bori,F Insua,S Marqueño,A Cobo,M Meseguer
STUDY QUESTION Could an artificial intelligence (AI) algorithm predict fetal heartbeat from images of vitrified-warmed embryos? SUMMARY ANSWER Applying AI to vitrified-warmed blastocysts may help predict which ones will result in implantation failure early enough to thaw another. WHAT IS KNOWN ALREADY The application of AI in the field of embryology has already proven effective in assessing the quality
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Reply. Exploring the impact of fertility-preserving treatment on pregnancy: key issues in patients with endometrial cancer and atypical hyperplasia. Hum. Reprod. (IF 6.0) Pub Date : 2024-08-22 Radostina Vasileva,Martin Koskas
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Challenges ahead: catalyzing research for the 2% prevalence of repeated implantation failure. Hum. Reprod. (IF 6.0) Pub Date : 2024-08-22 Hossam Elzeiny
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Embryo multinucleation: detection, possible origins, and implications for treatment Hum. Reprod. (IF 6.0) Pub Date : 2024-08-22 Giovanni Coticchio, Cristina Lagalla, Marilena Taggi, Danilo Cimadomo, Laura Rienzi
Cell cycle regulation is crucial to assure expansion of a cell population, while preserving genome integrity. This notion is especially relevant to fertilization and early embryo development, a time when the cell cycle transforms from meiotic into mitotic cycles. Zygote-to-embryo transition is acutely error-prone, causing major developmental perturbations, including cleavage delays, tri- and multi-chotomous
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Road to in vitro maturation (IVM), from basic science to an informed clinical practice. Hum. Reprod. (IF 6.0) Pub Date : 2024-08-07 Sofia Makieva,Juan J Fraire-Zamora,Omar Farhan Ammar,George Liperis,Flor Sanchez,Christian C Kramme,Lan N Vuong,Robert B Gilchrist,Pietro Bortoletto,Claudia Massarotti
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Is AMH a promising predictive biomarker for mTESE success in iNOA patients? Hum. Reprod. (IF 6.0) Pub Date : 2024-08-07 Julia Uraji,Juan J Fraire-Zamora,Claudia Massarotti,Sofia Makieva,George Liperis,Kashish Sharma,Sarah Martins da Silva,Raevti Bole,Jackson C Kirkman-Brown,Omar Farhan Ammar
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The importance of the 'uterine factor' in recurrent pregnancy loss: a retrospective cohort study on women screened through 3D transvaginal ultrasound. Hum. Reprod. (IF 6.0) Pub Date : 2024-08-01 Andrea Busnelli,Greta Barbaro,Federica Pozzati,Silvia D'Ippolito,Martina Cristodoro,Elena Nobili,Giovanni Scambia,Nicoletta Di Simone
STUDY QUESTION What is the prevalence of congenital and acquired anomalies of the uterus in women with recurrent pregnancy loss (RPL) of unknown etiology examined using 3D transvaginal ultrasound (US)? SUMMARY ANSWER Depending on the adopted diagnostic criteria, the prevalence of partial septate uterus varies between 7% and 14% and a T-shaped uterus is 3% or 4%, while adenomyosis is 23%, at least one
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What protocol should not be adopted, and which patients should not be suggested double stimulation in the same ovarian cycle? A randomized controlled trial answers. Hum. Reprod. (IF 6.0) Pub Date : 2024-08-01 Carlo Alviggi,Hakan Yarali,Danilo Cimadomo,Laura Rienzi,Filippo Maria Ubaldi,Alberto Vaiarelli
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Unveiling the role of chronic inflammation in ovarian aging: insights into mechanisms and clinical implications. Hum. Reprod. (IF 6.0) Pub Date : 2024-08-01 Yutian Zeng,Chun Wang,Cuiting Yang,Xudong Shan,Xiang-Qian Meng,Ming Zhang
Ovarian aging, a natural process in women and various other female mammals as they age, is characterized by a decline in ovarian function and fertility due to a reduction in oocyte reserve and quality. This phenomenon is believed to result from a combination of genetic, hormonal, and environmental factors. While these factors collectively contribute to the shaping of ovarian aging, the substantial
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Cervical intraepithelial neoplasia and fecundability: a prospective cohort study. Hum. Reprod. (IF 6.0) Pub Date : 2024-08-01 Mette L Kristensen,Marianne Waldstrøm,Anne Sofie D Laursen,Katrine Eriksen,Sinna P Ulrichsen,Elizabeth E Hatch,Lauren A Wise,Kenneth J Rothman,Henrik T Sørensen,Ellen M Mikkelsen
STUDY QUESTION Is cervical intraepithelial neoplasia (CIN) associated with reduced fecundability, defined as the probability of conceiving per menstrual cycle? SUMMARY ANSWER Overall, we observed no meaningful association between CIN and fecundability, regardless of surgical status, although a recent diagnosis of moderate or severe CIN might be associated with slightly reduced fecundability for 2 years
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Questionnaire-based screening of adolescents and young adult women can identify markers associated with endometriosis. Hum. Reprod. (IF 6.0) Pub Date : 2024-08-01 Charles Chapron,Louis Marcellin,Lorraine Maitrot-Mantelet,Mathilde Bourdon,Chloé Maignien,Guillaume Parpex,Pietro Santulli
STUDY QUESTION Do adolescents and young adult women (YAW) with histologically proven endometriosis present a specific clinical history? SUMMARY ANSWER Questionnaire screening of adolescents and YAW can identify clinical markers associated with histologically proven endometriosis. WHAT IS KNOWN ALREADY Some validated questionaries can contribute to an earlier endometriosis diagnosis in adults. None
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Fertility clinics have a duty of care towards patients who do not have children with treatment. Hum. Reprod. (IF 6.0) Pub Date : 2024-08-01 S Gameiro,D Leone,H Mertes
In medically assisted reproduction (MAR) success has mostly been measured in terms of achieving (healthy) livebirths. We argue this focus is too narrow and that success should be measured in terms of alleviating patient suffering caused by an unfulfilled child wish. The major implication is that clinics must better tailored care to effectively support patients who do not have child(ren) with treatment
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The association between reproductive history and abdominal adipose tissue among postmenopausal women: results from the Women's Health Initiative. Hum. Reprod. (IF 6.0) Pub Date : 2024-08-01 Hailey R Banack,Claire E Cook,Sonia M Grandi,Natalie V Scime,Rana Andary,Shawna Follis,Matthew Allison,JoAnn E Manson,Su Yong Jung,Robert A Wild,Leslie V Farland,Aladdin H Shadyab,Jennifer W Bea,Andrew O Odegaard
STUDY QUESTION What is the association between reproductive health history (e.g. age at menarche, menopause, reproductive lifespan) with abdominal adiposity in postmenopausal women? SUMMARY ANSWER Higher visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) tissue levels were observed among women with earlier menarche, earlier menopause, and greater parity. WHAT IS KNOWN ALREADY Postmenopausal
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Effect of intraovarian PRP injection in woman with poor ovarian reserve is still open to debate. Hum. Reprod. (IF 6.0) Pub Date : 2024-08-01 Zaher Merhi
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Overview of crosstalk between stromal and epithelial cells in the pathogenesis of adenomyosis and shared features with deep endometriotic nodules. Hum. Reprod. (IF 6.0) Pub Date : 2024-08-01 Margherita Zipponi,Luciana Cacciottola,Marie-Madeleine Dolmans
Since the first description of adenomyosis more than 150 years ago, multiple hypotheses have attempted to explain its pathogenesis. Indeed, research over recent years has greatly enhanced our knowledge of the underlying causes. This has opened up avenues for the development of strategies for both disease prevention and treatment of its main symptoms, such as pelvic pain, heavy menstrual bleeding, and
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Variation of sperm quality and circular RNA content in men exposed to environmental contamination with heavy metals in 'Land of Fires', Italy. Hum. Reprod. (IF 6.0) Pub Date : 2024-08-01 Vincenza Grazia Mele,Teresa Chioccarelli,Nadia Diano,Donato Cappetta,Bruno Ferraro,Marialucia Telesca,Martina Moggio,Veronica Porreca,Antonella De Angelis,Liberato Berrino,Silvia Fasano,Gilda Cobellis,Rosanna Chianese,Francesco Manfrevola
STUDY QUESTION Can illegal discharge of toxic waste into the environment induce a new condition of morpho-epigenetic pathozoospermia in normozoospermic young men? SUMMARY ANSWER Toxic environmental contaminants promote the onset of a new pathozoospermic condition in young normozoospermic men, consisting of morpho-functional defects and a sperm increase of low-quality circular RNA (circRNA) cargo, tightly
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Eggsurance? A randomized controlled trial of a decision aid for elective egg freezing. Hum. Reprod. (IF 6.0) Pub Date : 2024-08-01 Sherine Sandhu,Martha Hickey,Digsu N Koye,Sabine Braat,Raelia Lew,Roger Hart,Robert J Norman,Karin Hammarberg,Richard A Anderson,Michelle Peate,
STUDY QUESTION Does a purpose-designed Decision Aid for women considering elective egg freezing (EEF) impact decisional conflict and other decision-related outcomes? SUMMARY ANSWER The Decision Aid reduces decisional conflict, prepares women for decision-making, and does not cause distress. WHAT IS ALREADY KNOWN Elective egg-freezing decisions are complex, with 78% of women reporting high decisional
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Assessment of active translation in cumulus-enclosed and denuded oocytes during standard in vitro maturation and early embryo development. Hum. Reprod. (IF 6.0) Pub Date : 2024-08-01 M Dvoran,R Iyyappan,T Masek,M Pospisek,M Kubelka,A Susor
STUDY QUESTION Which actively translated maternal transcripts are differentially regulated between clinically relevant in vitro and in vivo maturation (IVM) conditions in mouse oocytes and zygotes? SUMMARY ANSWER Our findings uncovered significant differences in the global transcriptome as well as alterations in the translation of specific transcripts encoding components of energy production, cell
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Arrangement into layers and mechanobiology of multi-cell co-culture models of the uterine wall. Hum. Reprod. (IF 6.0) Pub Date : 2024-08-01 Yael Shlomo,Mark Gavriel,Ariel J Jaffa,Dan Grisaru,David Elad
STUDY QUESTION Can a co-culture of three cell types mimic the in vivo layers of the uterine wall? SUMMARY ANSWER Three protocols tested for co-culture of endometrial epithelial cells (EEC), endometrial stromal cells (ESC), and myometrial smooth muscle cells (MSMC) led to formation of the distinct layers that are characteristic of the structure of the uterine wall in vivo. WHAT IS KNOWN ALREADY We previously
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Morphological quality on Day 3 affects the pregnancy outcomes of low-quality euploid blastocysts: a retrospective cohort study. Hum. Reprod. (IF 6.0) Pub Date : 2024-08-01 Wanjun Zhang,Hao Shi,Wenbin Niu,Bo Sun,Yile Zhang,Fang Wang
STUDY QUESTION Does the morphological quality on Day 3 influence the pregnancy outcomes of euploid blastocysts? SUMMARY ANSWER The morphological quality on Day 3 affects the clinical pregnancy rate (CPR) and live birth rate (LBR) of low-quality euploid blastocysts. WHAT IS KNOWN ALREADY The morphological grading of Day 3 embryos affects the pregnancy outcome of cleavage-stage embryos and is an excellent
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Progesterone levels do not differ between patients with or without endometriosis/adenomyosis both in those who conceive after hormone replacement therapy-frozen embryo transfer cycles and those who do not. Hum. Reprod. (IF 6.0) Pub Date : 2024-08-01 M Bourdon,M Sorel,C Maignien,J Guibourdenche,C Patrat,L Marcellin,T Jobin,C Chapron,P Santulli
STUDY QUESTION Do women with endometriosis who achieve a live birth (LB) after HRT-frozen embryo transfer (HRT-FET) have different progesterone levels on the day of transfer compared to unaffected women? SUMMARY ANSWER In women achieving a LB after HRT-FET, serum progesterone levels on the day of the transfer did not differ between patients with endometriosis and unaffected patients. WHAT IS KNOWN
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Recent decline in sperm motility among donor candidates at a sperm bank in Denmark. Hum. Reprod. (IF 6.0) Pub Date : 2024-08-01 Emilie Lassen,Allan Pacey,Anne-Bine Skytte,Robert Montgomerie
STUDY QUESTION Has there been variation in semen quality among men applying to be sperm donors (i.e. donor candidates) in Denmark in recent years (2017-2022)? SUMMARY ANSWER The motile sperm concentration and total motile sperm count (TMSC) in ejaculates-both measures of sperm quality-declined by as much as 22% from 2019 to 2022. WHAT IS KNOWN ALREADY Questions remain about whether human semen quality
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The nexus of fertility and politics: exploring the influence of social tolerance, religiosity, and political conservatism on the acceptance of assisted reproduction in Spain. Hum. Reprod. (IF 6.0) Pub Date : 2024-09-01 Maite Aurrekoetxea-Casaus,Lorena Ronda
STUDY QUESTION How do individual religious, political, and social tolerance orientations influence the acceptance of ART among Spanish citizens? SUMMARY ANSWER Social tolerance and religiosity are predictive factors for the acceptance of ART, with more tolerant individuals and those with lower levels of religiosity being more accepting of ART; political conservatism mediates the relationship between
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Women’s interest, knowledge, and attitudes relating to anti-Mullerian hormone testing: a randomized controlled trial Hum. Reprod. (IF 6.0) Pub Date : 2024-07-29 T Copp, T van Nieuwenhoven, K J McCaffery, K Hammarberg, E Cvejic, J Doust, S Lensen, M Peate, L Augustine, F van der Mee, B W Mol, D Lieberman, J Jansen
STUDY QUESTION What is the impact of co-designed, evidence-based information regarding the anti-Mullerian hormone (AMH) test on women’s interest in having the test? SUMMARY ANSWER Women who viewed the evidence-based information about the AMH test had lower interest in having an AMH test than women who viewed information produced by an online company selling the test direct-to-consumers. WHAT IS KNOWN
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Mothers of twins had higher old-age survival than mothers of singletons in Estonian 19th-century birth cohorts. Hum. Reprod. (IF 6.0) Pub Date : 2024-09-01 R Meitern,M Gortfelder,A Puur,P Hõrak
STUDY QUESTION Do the mothers of twins and singletons differ regarding post-partum and old-age mortality? SUMMARY ANSWER Twin deliveries were associated with higher post-partum maternal mortality than singleton deliveries, but the lifetime post-partum mortality risk was similar for mothers of twins and singletons; survival of twinners was higher than survival of the mothers of singletons after the
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The impact of implementing a non-invasive preimplantation genetic testing for aneuploidies (niPGT-A) embryo culture protocol on embryo viability and clinical outcomes. Hum. Reprod. (IF 6.0) Pub Date : 2024-09-01 Denny Sakkas,Luis Navarro-Sánchez,Goli Ardestani,Gerardo Barroso,Claudio Bisioli,Kubra Boynukalin,Danilo Cimadomo,Nilo Frantz,Laura Kopcow,Gabriella Mamede Andrade,Bilgen Ozturk,Laura Rienzi,Ariane Weiser,Diana Valbuena,Carlos Simón,Carmen Rubio
STUDY QUESTION Are modifications in the embryo culture protocol needed to perform non-invasive preimplantation genetic testing for aneuploidies (niPGT-A) affecting clinical reproductive outcomes, including blastocyst development and pregnancy outcomes? SUMMARY ANSWER The implementation of an embryo culture protocol to accommodate niPGT-A has no impact on blastocyst viability or pregnancy outcomes.