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Reciprocal Effects Between Negative Parenting and Children’s Callous-Unemotional Traits From Mid to Late Childhood Am. J. Psychiatry (IF 17.7) Pub Date : 2024-03-13 Patrizia Pezzoli, Jean-Baptiste Pingault, Margherita Malanchini, Ivan Voronin, Eamon McCrory, Pasco Fearon, Essi Viding
Objective: The role of negative parenting in the development of callous-unemotional (CU) traits remains unclear. Both negative parenting and CU traits are influenced by genetic and environmental factors. The authors used genetically informed longitudinal cross-lagged models to examine the extent to which reciprocal effects between negative parenting and children’s CU traits in mid-to-late childhood
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Subcortico-Cortical Dysconnectivity in ADHD: A Voxel-Wise Mega-Analysis Across Multiple Cohorts Am. J. Psychiatry (IF 17.7) Pub Date : 2024-03-13 Luke J. Norman, Gustavo Sudre, Jolie Price, Philip Shaw
Objective: A large body of functional MRI research has examined a potential role for subcortico-cortical loops in the pathogenesis of attention deficit hyperactivity disorder (ADHD), but has produced inconsistent findings. The authors performed a mega-analysis of six neuroimaging data sets to examine associations between ADHD diagnosis and traits and subcortico-cortical connectivity. Methods: Group
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Neuromelanin-Sensitive MRI as Candidate Marker for Treatment Resistance in First-Episode Schizophrenia Am. J. Psychiatry (IF 17.7) Pub Date : 2024-03-13 Marieke van der Pluijm, Kenneth Wengler, Pascalle N. Reijers, Clifford M. Cassidy, Kaithlyn Tjong Tjin Joe, Olav R. de Peuter, Guillermo Horga, Jan Booij, Lieuwe de Haan, Elsmarieke van de Giessen
Objective: Markers for treatment resistance in schizophrenia are needed to reduce delays in effective treatment. Nigrostriatal hyperdopaminergic function plays a critical role in the pathology of schizophrenia, yet antipsychotic nonresponders do not show increased dopamine function. Neuromelanin-sensitive MRI (NM-MRI), which indirectly measures dopamine function in the substantia nigra, has potential
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Durability of Effects of Cognitive Remediation on Cognition and Psychosocial Functioning in Schizophrenia: A Systematic Review and Meta-Analysis of Randomized Clinical Trials Am. J. Psychiatry (IF 17.7) Pub Date : 2024-03-13 Antonio Vita, Stefano Barlati, Anna Ceraso, Gabriele Nibbio, Francesca Durante, Michele Facchi, Giacomo Deste, Til Wykes
Objective: Cognitive remediation provides substantial improvements in cognitive performance and real-world functioning for people living with schizophrenia, but the durability of these benefits needs to be reassessed and better defined. The aims of this study were to provide a comprehensive assessment of the durability of the benefits of cognitive remediation for cognition and functioning in people
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Irritability in Youths: A Critical Integrative Review Am. J. Psychiatry (IF 17.7) Pub Date : 2024-02-29 Ellen Leibenluft, Laura E. Allen, Robert R. Althoff, Melissa A. Brotman, Jeffrey D. Burke, Gabrielle A. Carlson, Daniel P. Dickstein, Lea R. Dougherty, Spencer C. Evans, Katharina Kircanski, Daniel N. Klein, Eleanor P. Malone, Carla A. Mazefsky, Joel Nigg, Susan B. Perlman, Daniel S. Pine, Amy Krain Roy, Giovanni A. Salum, Amy Shakeshaft, Jamilah Silver, Joel Stoddard, Anita Thapar, Wan-Ling Tseng
Irritability, defined as proneness to anger that may impair an individual’s functioning, is common in youths. There has been a recent upsurge in relevant research. The authors combine systematic and narrative review approaches to integrate the latest clinical and translational findings and provide suggestions for addressing research gaps. Clinicians and researchers should assess irritability routinely
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N2 Responses in Youths With Psychosis Risk Syndrome and Their Association With Clinical Outcomes: A Cohort Follow-Up Study Based on the Three-Stimulus Visual Oddball Paradigm Am. J. Psychiatry (IF 17.7) Pub Date : 2024-02-29 Yongqing Hou, Haishuo Xia, Tianbao He, Bohua Zhang, Guiping Qiu, Antao Chen
Objective: Schizophrenia often occurs during youth, and psychosis risk syndrome occurs before the onset of psychosis. The aim of this study was to determine whether the visual event-related potential responses in youths with psychosis risk syndrome were defective in the presence of interference stimuli and associated with their clinical outcomes. Methods: A total of 223 participants, including 122
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Current and Future Approaches to Pediatric Anxiety Disorder Treatment Am. J. Psychiatry (IF 17.7) Pub Date : 2024-03-01 Andre Zugman, Anderson M. Winkler, Purnima Qamar, Daniel S. Pine
This overview critically appraises the literature on the treatment of pediatric anxiety disorders. The two established treatments for these conditions comprise cognitive-behavioral therapy (CBT) and antidepressant medications. Many youths receiving these treatments fail to achieve remission, which creates a need for new treatments. After summarizing the literature on CBT and currently available medications
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Neural Responses to Intranasal Oxytocin in Youths With Severe Irritability Am. J. Psychiatry (IF 17.7) Pub Date : 2024-02-29 Soonjo Hwang, Ji-Woo Suk, Harma Meffert, Arica Lerdahl, William F. Garvey, Ryan Edwards, Alison Delizza, Brigette Soltis-Vaughan, Katrina Cordts, Ellen Leibenluft, R.J.R. Blair
Objective: The authors investigated the neural impact of intranasal oxytocin on emotion processing areas in youths with severe irritability in the context of disruptive mood and behavior disorders. Methods: Fifty-two participants with severe irritability, as measured by a score ≥4 on the Affective Reactivity Index (ARI), with diagnoses of disruptive behavior disorders (DBDs) and/or disruptive mood
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Pattern of Risks for Psychiatric and Substance Use Disorders in the Offspring of Parents With Alcohol Use Disorder Am. J. Psychiatry (IF 17.7) Pub Date : 2024-02-29 Kenneth S. Kendler, Linda Abrahamsson, Jan Sundquist, Kristina Sundquist
Objective: The authors sought to clarify the components of the familial liability to alcohol use disorder (AUD) by examining parent-offspring transmission in a large Swedish population sample. Methods: To this end, 1,244,516 offspring in intact families with a mean age at follow-up of 37.7 years (SD=6.8) were examined. Hazard ratios for offspring of parents with AUD were calculated using Cox models
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Cognitive Outcomes After Antidepressant Pharmacotherapy for Late-Life Depression: A Systematic Review and Meta-Analysis Am. J. Psychiatry (IF 17.7) Pub Date : 2024-02-07 Nicholas J. Ainsworth, Tulip Marawi, Marta M. Maslej, Daniel M. Blumberger, Mary Pat McAndrews, Argyrios Perivolaris, Bruce G. Pollock, Tarek K. Rajji, Benoit H. Mulsant
Objective: The authors evaluated whether treatment of late-life depression (LLD) with antidepressants leads to changes in cognitive function. Methods: A systematic review and meta-analysis of prospective studies of antidepressant pharmacotherapy for adults age 50 or older (or mean age of 65 or older) with LLD was conducted. MEDLINE, EMBASE, and PsycInfo were searched through December 31, 2022. The
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Treatment Response Prediction in Major Depressive Disorder Using Multimodal MRI and Clinical Data: Secondary Analysis of a Randomized Clinical Trial Am. J. Psychiatry (IF 17.7) Pub Date : 2024-02-07 Maarten G. Poirot, Henricus G. Ruhe, Henk-Jan M.M. Mutsaerts, Ivan I. Maximov, Inge R. Groote, Atle Bjørnerud, Henk A. Marquering, Liesbeth Reneman, Matthan W.A. Caan
Objective: Response to antidepressant treatment in major depressive disorder varies substantially between individuals, which lengthens the process of finding effective treatment. The authors sought to determine whether a multimodal machine learning approach could predict early sertraline response in patients with major depressive disorder. They assessed the predictive contribution of MR neuroimaging
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Intergenerational Effects of the Fast Track Intervention on Next-Generation Child Outcomes: A Preregistered Randomized Clinical Trial Am. J. Psychiatry (IF 17.7) Pub Date : 2024-02-07 W. Andrew Rothenberg, Jennifer E. Lansford, Jennifer W. Godwin, Kenneth A. Dodge, William E. Copeland, Candice L. Odgers, Robert J. McMahon, Anna Rybinska, Conduct Problems Prevention Research Group
Objective: The authors sought to determine whether the Fast Track mental health intervention delivered to individuals in childhood decreased mental health problems and the need for health services among the children of these individuals. Methods: The authors examined whether Fast Track assignment in one generation of children (generation 2; G2) from grades 1 through 10 reduced parent-reported mental
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Associations Between General and Specific Mental Health Conditions in Young Adulthood and Cardiometabolic Complications in Middle Adulthood: A 40-Year Longitudinal Familial Coaggregation Study of 672,823 Swedish Individuals Am. J. Psychiatry (IF 17.7) Pub Date : 2024-01-24 Cen Chen, Zheng Chang, Ralf Kuja-Halkola, Brian M. D’Onofrio, Henrik Larsson, Pontus Andell, Paul Lichtenstein, Erik Pettersson
Objective: Most mental disorders, when examined individually, are associated with an increased risk of cardiometabolic complications. However, these associations might be attributed to a general liability to psychopathology or confounded by unmeasured familial factors. The authors investigated the association between psychiatric conditions in young adulthood and the risk of cardiometabolic complications
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Normalization of Fronto-Parietal Activation by Cognitive-Behavioral Therapy in Unmedicated Pediatric Patients With Anxiety Disorders Am. J. Psychiatry (IF 17.7) Pub Date : 2024-01-24 Simone P. Haller, Julia O. Linke, Hannah L. Grassie, Emily L. Jones, David Pagliaccio, Anita Harrewijn, Lauren K. White, Reut Naim, Rany Abend, Ajitha Mallidi, Erin Berman, Krystal M. Lewis, Katharina Kircanski, Nathan A. Fox, Wendy K. Silverman, Ned H. Kalin, Yair Bar-Haim, Melissa A. Brotman
Objective: Anxiety disorders are prevalent among youths and are often highly impairing. Cognitive-behavioral therapy (CBT) is an effective first-line treatment. The authors investigated the brain mechanisms associated with symptom change following CBT. Methods: Unmedicated youths diagnosed with an anxiety disorder underwent 12 weeks of CBT as part of two randomized clinical trials testing the efficacy
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Mindfulness-Oriented Recovery Enhancement for Veterans and Military Personnel on Long-Term Opioid Therapy for Chronic Pain: A Randomized Clinical Trial Am. J. Psychiatry (IF 17.7) Pub Date : 2024-01-10 Eric L. Garland, Yoshio Nakamura, Craig J. Bryan, Adam W. Hanley, Anna Parisi, Brett Froeliger, William R. Marchand, Gary W. Donaldson
Objective: This randomized clinical trial evaluated the efficacy of Mindfulness-Oriented Recovery Enhancement (MORE) among past and present U.S. military personnel with prescriptions for long-term opioid therapy for chronic pain. Methods: In this clinical trial, 230 past and present military personnel with prescriptions for long-term opioid therapy were randomized in a 1:1 ratio to MORE or supportive
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Associations of Menstrual Cycle and Progesterone-to-Estradiol Ratio With Alcohol Consumption in Alcohol Use Disorder: A Sex-Separated Multicenter Longitudinal Study Am. J. Psychiatry (IF 17.7) Pub Date : 2024-01-10 Sabine Hoffmann, Sarah Gerhardt, Christiane Mühle, Iris Reinhard, Dominic Reichert, Patrick Bach, Rafat Boroumand-Jazi, Christine Kuehner, Alvaro Aguilera, Acelya Aslan, Nadja S. Bahr, Matthew Belanger, Friederike Deeken, Claudia Ebrahimi, Pascale C. Fischbach, Marvin Ganz, Maria Garbusow, Charlotte M. Großkopf, Marie Heigert, Angela Hentschel, Damian Karl, Shuyan Liu, Massimiliano Mazza, Patricia
Objective: Alcohol use disorder (AUD) constitutes a critical public health issue and has sex-specific characteristics. Initial evidence suggests that progesterone and estradiol might reduce or increase alcohol intake, respectively. However, there is a need for a better understanding of how the menstrual cycle in females and the ratio of progesterone to estradiol in females and males influence alcohol
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Psychotropic Drug–Related Weight Gain and Its Treatment Am. J. Psychiatry (IF 17.7) Pub Date : 2024-01-01 Roger S. McIntyre, Angela T.H. Kwan, Joshua D. Rosenblat, Kayla M. Teopiz, Rodrigo B. Mansur
Psychotropic drug–related weight gain (PDWG) is a common occurrence and is highly associated with non-initiation, discontinuation, and dissatisfaction with psychiatric drugs. Moreover, PDWG intersects with the elevated risk for obesity and associated morbidity that has been amply reported in the psychiatric population. Evidence indicates that differential liability for PDWG exists for antipsychotics
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Predicting Acute Changes in Suicidal Ideation and Planning: A Longitudinal Study of Symptom Mediators and the Role of the Menstrual Cycle in Female Psychiatric Outpatients With Suicidality Am. J. Psychiatry (IF 17.7) Pub Date : 2023-12-14 Jaclyn M. Ross, Jordan C. Barone, Hafsah Tauseef, Katja M. Schmalenberger, Anisha Nagpal, Natania A. Crane, Tory A. Eisenlohr-Moul
Objective: Cross-sectional and preliminary longitudinal findings suggest that cyclical ovarian hormone fluctuations influence acute suicide risk. The authors provide the first analyses in females with suicidality to investigate which daily symptoms covary with suicidal ideation and planning thoughts, the role of the menstrual cycle in daily symptom variation, how daily fluctuations in symptoms mediate
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Resilience Isn't Found in Trauma, But It May Be Found in Other Life Experiences. Am. J. Psychiatry (IF 17.7) Pub Date : 2023-12-01 Cavan V Bonner,Brent W Roberts
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Adversity and Resilience, Postpartum Depression, Suicide, and Racial/Ethnic Disparities. Am. J. Psychiatry (IF 17.7) Pub Date : 2023-12-01 Ned H Kalin
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The First Large GWAS Meta-Analysis for Postpartum Depression. Am. J. Psychiatry (IF 17.7) Pub Date : 2023-12-01 Jessica Ann May Adams,Prabha Chandra,Divya Mehta
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The STAR*D Data Remain Strong: Reply to Pigott et al. Am. J. Psychiatry (IF 17.7) Pub Date : 2023-12-01 A John Rush,Madhukar Trivedi,Maurizio Fava,Michael Thase,Stephen Wisniewski
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The Consolidated Appropriations Act, 2023: Implications for the Nation's Mental Health Crisis. Am. J. Psychiatry (IF 17.7) Pub Date : 2023-12-01 Joseph H Wu,Eli Y Adashi
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Substance Use Disorders Are Psychiatric Disorders. Am. J. Psychiatry (IF 17.7) Pub Date : 2023-12-01 Alëna A Balasanova
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Substance Use Disorders Are Psychiatric Disorders: Response to Balasanova. Am. J. Psychiatry (IF 17.7) Pub Date : 2023-12-01 Ned H Kalin
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A Mental Health Crisis and Call to Action: Increasing Trends in Suicide Among Black Women in the United States. Am. J. Psychiatry (IF 17.7) Pub Date : 2023-12-01 Ruth S Shim,Carolyn I Rodriguez
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Perinatal Mental Health: Advances and Opportunities. Am. J. Psychiatry (IF 17.7) Pub Date : 2023-12-01 Zachary N Stowe
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Recurrent Anti-NMDA Receptor Encephalitis After Mycoplasma Pneumonia Infection. Am. J. Psychiatry (IF 17.7) Pub Date : 2023-12-01 Katherine S Dickson,Donald L Rosenstein,Nathaniel A Sowa
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Learning From Racial Disparities in COVID-19-Related Stress. Am. J. Psychiatry (IF 17.7) Pub Date : 2023-12-01 Rachel Yehuda,Sidney H Hankerson
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Trends in Suicide Among Black Women in the United States, 1999-2020. Am. J. Psychiatry (IF 17.7) Pub Date : 2023-12-01 Victoria A Joseph,Gonzalo Martínez-Alés,Mark Olfson,Jeffrey Shaman,Madelyn S Gould,Catherine Gimbrone,Katherine M Keyes
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Trends in Prevalence of Cannabis Use Disorder Among U.S. Veterans With and Without Psychiatric Disorders Between 2005 and 2019 Am. J. Psychiatry (IF 17.7) Pub Date : 2023-11-29 Ofir Livne, Carol A. Malte, Mark Olfson, Melanie M. Wall, Katherine M. Keyes, Charles Maynard, Jaimie L. Gradus, Andrew J. Saxon, Silvia S. Martins, Salomeh Keyhani, Yoanna McDowell, David S. Fink, Zachary L. Mannes, Sarah Gutkind, Deborah S. Hasin
Objective: Cannabis use disorder diagnoses are increasing among U.S. adults and are more prevalent among people with comorbid psychiatric disorders. Recent changes in cannabis laws, increasing cannabis availability, and higher-potency cannabis may have placed people with cannabis use and psychiatric disorders at disproportionately increasing risk for cannabis use disorder. The authors used Veterans
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The Long-Term Relationship Between Cannabis and Heroin Use: An 18- to 20-year Follow-Up of the Australian Treatment Outcome Study (ATOS) Am. J. Psychiatry (IF 17.7) Pub Date : 2023-11-29 Jack Wilson, Katherine L. Mills, Matthew Sunderland, Tom P. Freeman, Maree Teesson, Paul S. Haber, Christina Marel
Objective: Cannabis use is common among individuals with opioid use disorder, but it remains unclear whether cannabis use is associated with an increase or a reduction in illicit opioid use. To overcome limitations identified in previous longitudinal studies with limited follow-ups, the authors examined a within-person reciprocal relationship between cannabis and heroin use at several follow-ups over
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Converging Evidence for Frontopolar Cortex as a Target for Neuromodulation in Addiction Treatment Am. J. Psychiatry (IF 17.7) Pub Date : 2023-11-29 Ghazaleh Soleimani, Juho Joutsa, Khaled Moussawi, Shan H. Siddiqi, Rayus Kuplicki, Marom Bikson, Martin P. Paulus, Michael D. Fox, Colleen A. Hanlon, Hamed Ekhtiari
Noninvasive brain stimulation technologies such as transcranial electrical and magnetic stimulation (tES and TMS) are emerging neuromodulation therapies that are being used to target the neural substrates of substance use disorders. By the end of 2022, 205 trials of tES or TMS in the treatment of substance use disorders had been published, with heterogeneous results, and there is still no consensus
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Adult Mental Health, Substance Use Disorders, and Functional Outcomes of Children Resilient to Early Adversity Am. J. Psychiatry (IF 17.7) Pub Date : 2023-11-09 William E. Copeland, Julia Halvorson-Phelan, Ellen McGinnis, Lilly Shanahan
Objective: Some children are unaffected by mental illness despite exposure to childhood adversity. These children are typically considered resilient. The objective of this study was to follow up such resilient children in adulthood to characterize mental health status, substance use, and functional outcomes. Methods: The analysis was based on the prospective, representative Great Smoky Mountains Study
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Racial and Ethnic Disparities in COVID-19-Related Stressor Exposure and Adverse Mental Health Outcomes Among Health Care Workers. Am. J. Psychiatry (IF 17.7) Pub Date : 2023-11-09 Aaron Samuel Breslow,Sherry Simkovic,Peter J Franz,Elizabeth Cavic,Qi Liu,Natalie Ramsey,Jonathan E Alpert,Benjamin Le Cook,Vilma Gabbay
OBJECTIVE Racial and ethnic disparities in exposure to COVID-19-related stressors, pandemic-related distress, and adverse mental health outcomes were assessed among health care workers in the Bronx, New York, during the first wave of the pandemic. METHODS The authors analyzed survey data from 992 health care workers using adjusted logistic regression models to assess differential prevalence of outcomes
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An Avenue for Optimization of Theta Burst Stimulation Protocols? Comments on the FOUR-D Randomized Noninferiority Clinical Trial. Am. J. Psychiatry (IF 17.7) Pub Date : 2023-11-02 Jean-Marie V Batail,Michael T Feyder,Brandon S Bentzley,Nolan R Williams
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Recapitulation of Perturbed Striatal Gene Expression Dynamics of Donor’s Brains With Ventral Forebrain Organoids Derived From the Same Individuals With Schizophrenia Am. J. Psychiatry (IF 17.7) Pub Date : 2023-11-02 Tomoyo Sawada, André R. Barbosa, Bruno Araujo, Alejandra E. McCord, Laura D’Ignazio, Kynon J.M. Benjamin, Bonna Sheehan, Michael Zabolocki, Arthur Feltrin, Ria Arora, Anna C. Brandtjen, Joel E. Kleinman, Thomas M. Hyde, Cedric Bardy, Daniel R. Weinberger, Apuã C.M. Paquola, Jennifer A. Erwin
Objective: Schizophrenia is a brain disorder that originates during neurodevelopment and has complex genetic and environmental etiologies. Despite decades of clinical evidence of altered striatal function in affected patients, studies examining its cellular and molecular mechanisms in humans are limited. To explore neurodevelopmental alterations in the striatum associated with schizophrenia, the authors
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Structural Racism and Risk of Schizophrenia. Am. J. Psychiatry (IF 17.7) Pub Date : 2023-11-01 Els van der Ven,Ezra Susser
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Predicting Conversion to Psychosis Using Machine Learning: Are We There Yet? Am. J. Psychiatry (IF 17.7) Pub Date : 2023-11-01 Tyrone D Cannon
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Points that Need Attention in Early Auditory Information Processing Research in Schizophrenia: Response to Lin and Hsieh. Am. J. Psychiatry (IF 17.7) Pub Date : 2023-11-01 Yash Joshi,Neal Swerdlow,Gregory Light
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Another Step Toward the Prediction of Antipsychotic Treatment Response Using Functional Connectivity. Am. J. Psychiatry (IF 17.7) Pub Date : 2023-11-01 Donald C Goff,Joshua Roffman,Daphne J Holt
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Dissecting the Genetic Relationship Between Schizophrenia and Cardiovascular Disease. Am. J. Psychiatry (IF 17.7) Pub Date : 2023-11-01 Rona J Strawbridge,Nicholas Graham
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Rethinking the First Episode of Schizophrenia: Identifying Convergent Mechanisms During Development and Moving Toward Prediction. Am. J. Psychiatry (IF 17.7) Pub Date : 2023-11-01 Jennifer K Forsyth,Carrie E Bearden
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Meta-Analyses of Genome-Wide Association Studies for Postpartum Depression Am. J. Psychiatry (IF 17.7) Pub Date : 2023-10-18 Jerry Guintivano, Enda M. Byrne, Jacqueline Kiewa, Shuyang Yao, Anna E. Bauer, Karolina A. Aberg, Mark J. Adams, Archie Campbell, Megan L. Campbell, Karmel W. Choi, Elizabeth C. Corfield, Alexandra Havdahl, Donald Hucks, Nastassja Koen, Yi Lu, Merete L. Mægbæk, Jimmy Mullaert, Roseann E. Peterson, Laura M. Raffield, Hannah M. Sallis, Julia M. Sealock, Alicia Walker, Hunna J. Watson, Ying Xiong, Jessica
Objective: Postpartum depression (PPD) is a common subtype of major depressive disorder (MDD) that is more heritable, yet is understudied in psychiatric genetics. The authors conducted meta-analyses of genome-wide association studies (GWASs) to investigate the genetic architecture of PPD. Method: Meta-analyses were conducted on 18 cohorts of European ancestry (17,339 PPD cases and 53,426 controls)
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Real-World Evidence on Clinical Outcomes of Commonly Used Antidepressants in Older Adults Initiating Antidepressants for Depression: A Nationwide Cohort Study in Denmark Am. J. Psychiatry (IF 17.7) Pub Date : 2023-10-18 Kazi Ishtiak-Ahmed, Katherine L. Musliner, Kaj Sparle Christensen, Erik Lykke Mortensen, Andrew A. Nierenberg, Christiane Gasse
Objective: The authors investigated the clinical outcomes of commonly used antidepressants among older adults who initiated first-time antidepressants for depression by analyzing the 1-year risk of selected clinically relevant outcomes. Methods: This cohort study used nationwide Danish registry data and included all older adults who redeemed a first-time (since 1995) antidepressant prescription with
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Are We There Yet? Predicting Conversion to Psychosis Using Machine Learning. Am. J. Psychiatry (IF 17.7) Pub Date : 2023-10-04 Jason Smucny,Ian Davidson,Cameron S Carter
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Inequalities in the Incidence of Psychotic Disorders Among Racial and Ethnic Groups Am. J. Psychiatry (IF 17.7) Pub Date : 2023-10-04 Winston Chung, Sheng-Fang Jiang, Michael P. Milham, Kathleen R. Merikangas, Diana Paksarian
Objective: The authors examined recent trends in incidence of psychotic disorders, demographic characteristics, and comorbid psychiatric and medical conditions among six racial/ethnic groups. Method: A retrospective cohort study design was used to examine the incidence of psychotic disorders across race/ethnicity groups and comorbid psychiatric and medical conditions among members of Kaiser Permanente
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Effects of Bundling Medication for Opioid Use Disorder With an mHealth Intervention Targeting Addiction: A Randomized Clinical Trial Am. J. Psychiatry (IF 17.7) Pub Date : 2023-10-04 David H. Gustafson, Sr., Gina Landucci, Olivia J. Vjorn, Rachel E. Gicquelais, Simon B. Goldberg, Darcie C. Johnston, John J. Curtin, Genie L. Bailey, Dhavan V. Shah, Klaren Pe-Romashko, David H. Gustafson, Jr.
Objective: Medication for opioid use disorder (MOUD) improves treatment retention and reduces illicit opioid use. A-CHESS is an evidence-based smartphone intervention shown to improve addiction-related behaviors. The authors tested the efficacy of MOUD alone versus MOUD plus A-CHESS to determine whether the combination further improved outcomes. Methods: In an unblinded parallel-group randomized controlled
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GWAS Meta-Analysis of Suicide Attempt: Identification of 12 Genome-Wide Significant Loci and Implication of Genetic Risks for Specific Health Factors. Am. J. Psychiatry (IF 17.7) Pub Date : 2023-10-01 Anna R Docherty,Niamh Mullins,Allison E Ashley-Koch,Xuejun Qin,Jonathan R I Coleman,Andrey Shabalin,JooEun Kang,Balasz Murnyak,Frank Wendt,Mark Adams,Adrian I Campos,Emily DiBlasi,Janice M Fullerton,Henry R Kranzler,Amanda V Bakian,Eric T Monson,Miguel E Rentería,Consuelo Walss-Bass,Ole A Andreassen,Chittaranjan Behera,Cynthia M Bulik,Howard J Edenberg,Ronald C Kessler,J John Mann,John I Nurnberger
OBJECTIVE Suicidal behavior is heritable and is a major cause of death worldwide. Two large-scale genome-wide association studies (GWASs) recently discovered and cross-validated genome-wide significant (GWS) loci for suicide attempt (SA). The present study leveraged the genetic cohorts from both studies to conduct the largest GWAS meta-analysis of SA to date. Multi-ancestry and admixture-specific meta-analyses
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Stress, Heritability, and Genetic Factors Influencing Depression, PTSD, and Suicidal Behavior. Am. J. Psychiatry (IF 17.7) Pub Date : 2023-10-01 Ned H Kalin
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Maternal Perinatal Stress Associated With Offspring Negative Emotionality, But the Underlying Mechanisms Remain Elusive. Am. J. Psychiatry (IF 17.7) Pub Date : 2023-10-01 Alexander J Shackman,Dylan G Gee
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New Insights Into Suicidal Behavior From Large Multi-Ancestry Genetic Meta-Analysis. Am. J. Psychiatry (IF 17.7) Pub Date : 2023-10-01 Elisabeth B Binder
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Characterizing the Shared Genetic Underpinnings of Schizophrenia and Cardiovascular Disease Risk Factors Am. J. Psychiatry (IF 17.7) Pub Date : 2023-09-27 Linn Rødevand, Zillur Rahman, Guy F.L. Hindley, Olav B. Smeland, Oleksandr Frei, Tahir Filiz Tekin, Gleda Kutrolli, Shahram Bahrami, Eva Z. Hoseth, Alexey Shadrin, Aihua Lin, Srdjan Djurovic, Anders M. Dale, Nils Eiel Steen, Ole A. Andreassen
Objective: Schizophrenia is associated with increased risk of cardiovascular disease (CVD), although there is variation in risk among individuals. There are indications of shared genetic etiology between schizophrenia and CVD, but the nature of the overlap remains unclear. The aim of this study was to fill this gap in knowledge. Methods: Overlapping genetic architectures between schizophrenia and CVD
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Recent Secular Trends of Body Mass Index in Individuals With Bipolar Disorders and in the General Population Am. J. Psychiatry (IF 17.7) Pub Date : 2023-09-20 Hemen Najar, Erik Joas, Viktor Jonsson, Erik Pålsson, Mikael Landén
Objective: The aims of this study were to investigate secular trends and distribution of body mass index (BMI) among individuals with bipolar disorders and the general population between 2008 and 2019. Methods: Data were from the Swedish National Quality Register for Bipolar Disorder, where 24,423 adults with bipolar disorders were identified, and from the national Swedish Living Conditions Surveys
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Long-Term Use of Benzodiazepines and Benzodiazepine-Related Drugs: A Register-Based Danish Cohort Study on Determinants and Risk of Dose Escalation Am. J. Psychiatry (IF 17.7) Pub Date : 2023-09-20 Thomas Wolff Rosenqvist, Marie Kim Wium-Andersen, Ida Kim Wium-Andersen, Martin Balslev Jørgensen, Merete Osler
Objective: The authors investigated the frequency and determinants of long-term use and risk of dose escalation of benzodiazepines and benzodiazepine-related drugs (benzodiazepine receptor agonists, or BZRAs). Methods: All adults ages 20–80 years living in Denmark on January 1, 2000 (N=4,297,045) were followed for redeemed prescriptions of BZRAs in the Danish National Prescription Registry from January
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Maternal Perinatal Stress Trajectories and Negative Affect and Amygdala Development in Offspring Am. J. Psychiatry (IF 17.7) Pub Date : 2023-09-06 Mollie C. Marr, Alice M. Graham, Eric Feczko, Saara Nolvi, Elina Thomas, Darrick Sturgeon, Emma Schifsky, Jerod M. Rasmussen, John H. Gilmore, Martin Styner, Sonja Entringer, Pathik D. Wadhwa, Riikka Korja, Hasse Karlsson, Linnea Karlsson, Claudia Buss, Damien A. Fair
Objective: Maternal psychological stress during pregnancy is a common risk factor for psychiatric disorders in offspring, but little is known about how heterogeneity of stress trajectories during pregnancy affect brain systems and behavioral phenotypes in infancy. This study was designed to address this gap in knowledge. Methods: Maternal anxiety, stress, and depression were assessed at multiple time
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Subcortical Anatomy in Neurogenetic Disorders: New Findings and Future Questions. Am. J. Psychiatry (IF 17.7) Pub Date : 2023-09-01 Konrad Wagstyl,Armin Raznahan
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Seeking New Solutions Addressing Structural Racism, Childhood Trauma, Suicidal Behaviors Across Sexual Orientations, and Postpartum Depression. Am. J. Psychiatry (IF 17.7) Pub Date : 2023-09-01 Ned H Kalin
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Through a Developmental Lens: Emerging Insights to Understand and Treat Pediatric PTSD. Am. J. Psychiatry (IF 17.7) Pub Date : 2023-09-01 Justin D Russell,Sara A Heyn,Ryan J Herringa
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Sexual Orientation and Suicidal Behavior: Is It Getting Better? Am. J. Psychiatry (IF 17.7) Pub Date : 2023-09-01 Gregory E Simon