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Professorships in child and adolescent psychiatry relative to a similarly sized medical specialty in the UK and Ireland: cross-sectional study Br. J. Psychiatry (IF 8.7) Pub Date : 2025-02-07 Ian Kelleher, Aleksandra Z. Poziemska, Valentina Kieseppä, Anita Thapar, Bernadka Dubicka, Elaine Lockhart, Tamsin Ford, Helen Minnis, Louise Gallagher, Fiona McNicholas, Kirstie O'Hare
Background A youth mental health crisis is considered one of the great challenges of our time, and research and clinical services in child and adolescent psychiatry have become a priority for governments and funders. Academic leadership is needed to drive forward research. It is not clear how many senior academic leadership posts (professorships) there are in child and adolescent psychiatry, nor how
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Is it now time to prepare psychiatry for a psychedelic future?: commentary, Breen et al. Br. J. Psychiatry (IF 8.7) Pub Date : 2025-02-06 Eugene G Breen,Faisal Al-Harbi
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Neural processes linking joint hypermobility and anxiety: key roles for the amygdala and insular cortex Br. J. Psychiatry (IF 8.7) Pub Date : 2025-02-03 Christina N. Kampoureli, Charlotte L. Rae, Cassandra Gould Van Praag, Neil A. Harrison, Sarah N. Garfinkel, Hugo D. Critchley, Jessica A. Eccles
Background Anxiety symptoms are elevated among people with joint hypermobility. The underlying neural mechanisms are attributed theoretically to effects of variant connective tissue on the precision of interoceptive representations contributing to emotions.Aim To investigate the neural correlates of anxiety and hypermobility using functional neuroimaging.Method We used functional magnetic resonance
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Impact of the COVID-19 pandemic on self-harm and self-harm/suicide ideation: population wide, data linkage study and time series analysis: Commentary, Patra et al Br. J. Psychiatry (IF 8.7) Pub Date : 2025-01-30 Bichitra Nanda Patra, Ananya Pant
The commentary raises important points like patients' actual availability of out- or in-patient services in the wake of pandemics and nationwide lockdowns. The focus is also drawn to missed opportunities to include data from hotlines and online services, a possible increase in death by suicides or changes in the factors that could add up to or protect a person from suicide.
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Alois Alzheimer and some of his lesser-known scientific contributions - Psychiatry in history. Br. J. Psychiatry (IF 8.7) Pub Date : 2025-01-30 Madhusudan Dalvi
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The dance of imperfection - Reflection. Br. J. Psychiatry (IF 8.7) Pub Date : 2025-01-30 Antonio Yaghy
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Prediction of suicidal behaviour as a three-body problem. Br. J. Psychiatry (IF 8.7) Pub Date : 2025-01-30 Philip J Batterham,Fiona Shand,Bridianne O'Dea
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Can liaison neurology add value to patient care within a mental health setting? Br. J. Psychiatry (IF 8.7) Pub Date : 2025-01-30 John H Ward,Brendan Sargent,Rob Bale,Johannes C Klein,Paul J Harrison,Belinda Lennox,Adam Al-Diwani,Adam E Handel
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Clozapine, relapse and adverse events: 10-year electronic cohort study in Canada: commentary, Kikuchi. Br. J. Psychiatry (IF 8.7) Pub Date : 2025-01-30 Yuki Kikuchi
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Clozapine, relapse, and adverse events: a 10-year electronic cohort study in Canada: commentary: author response. Br. J. Psychiatry (IF 8.7) Pub Date : 2025-01-30 Shawn Halayka,Lloyd Balbuena
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Evaluating Computerised Assessment of Motor Imitation (CAMI) for identifying autism-specific difficulties not observed for attention-deficit hyperactivity disorder or neurotypical development Br. J. Psychiatry (IF 8.7) Pub Date : 2025-01-28 Romila Santra, Carolina Pacheco, Deana Crocetti, René Vidal, Stewart H. Mostofsky, Bahar Tunçgenç
Background Reliable and specific biomarkers that can distinguish autism spectrum disorders (ASDs) from commonly co-occurring attention-deficit/hyperactivity disorder (ADHD) are lacking, causing misses and delays in diagnosis, and reducing access to interventions and quality of life.Aims To examine whether an innovative, brief (1-min), videogame method called Computerised Assessment of Motor Imitation
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Life expectancy and years of life lost for adults with diagnosed ADHD in the UK: matched cohort study Br. J. Psychiatry (IF 8.7) Pub Date : 2025-01-23 Elizabeth O'Nions, Céline El Baou, Amber John, Dan Lewer, Will Mandy, Douglas G.J. McKechnie, Irene Petersen, Josh Stott
Background Nearly 3% of adults have attention-deficit and hyperactivity disorder (ADHD), although in the UK, most are undiagnosed. Adults with ADHD on average experience poorer educational and employment outcomes, worse physical and mental health and are more likely to die prematurely. No studies have yet used mortality data to examine the life expectancy deficit experienced by adults with diagnosed
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Burden of depressive and anxiety disorders in China and its provinces, 1990–2021: findings from the Global Burden of Disease Study 2021 Br. J. Psychiatry (IF 8.7) Pub Date : 2025-01-22 Wei Tian, Guangcan Yan, Shangzhi Xiong, Jing Zhang, Junyi Peng, Xinyi Zhang, Yuanzhong Zhou, Tao Liu, Yafeng Zhang, Pengpeng Ye, Wenran Zhao, Maoyi Tian
Background Depressive and anxiety disorders constitute a major component of the disease burden of mental disorders in China.Aims To comprehensively evaluate the disease burden of depressive and anxiety disorders in China.Method The raw data is sourced from the Global Burden of Disease, Injuries, and Risk Factors Study (GBD) 2021. This study presented the disease burden by prevalence and disability-adjusted
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Functional and effective connectivity between reward and inhibitory control networks underlying subclinical binge eating Br. J. Psychiatry (IF 8.7) Pub Date : 2025-01-21 Ximei Chen, Wei Li, Yijun Luo, Yong Liu, Xiaofei Xu, Xiao Gao, Hong Chen
Background Knowledge is growing on the essential role of neural circuits involved in aberrant cognitive control and reward sensitivity for the onset and maintenance of binge eating.Aims To investigate how the brain's reward (bottom-up) and inhibition control (top-down) systems potentially and dynamically interact to contribute to subclinical binge eating.Method Functional magnetic resonance imaging
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Associations of mental disorders in children with parents' subsequent mental disorders: nationwide cohort study from Finland and Denmark Br. J. Psychiatry (IF 8.7) Pub Date : 2025-01-15 Christian Hakulinen, Mai Gutvilig, Ripsa Niemi, Natalie C. Momen, Laura Pulkki-Råback, Petri Böckerman, Oleguer Plana-Ripoll, Kaisla Komulainen, Marko Elovainio
Background Intergenerational transmission of mental disorders has been well established, but it is unclear whether exposure to a child's mental disorder increases parents' subsequent risk of mental disorders.Aims We examined the association of mental disorders in children with their parents' subsequent mental disorders.Method In this population-based cohort study, we included all individuals with children
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Global, regional and national burden of depressive disorders and attributable risk factors, from 1990 to 2021: results from the 2021 Global Burden of Disease study Br. J. Psychiatry (IF 8.7) Pub Date : 2025-01-15 Jian Rong, Xueqin Wang, Pan Cheng, Dan Li, Dahai Zhao
Background Depressive disorders pose a significant global public health challenge, yet evidence on their burden remains insufficient.Aims To report the global, regional and national burden of depressive disorders and their attributable risk factors from 1990 to 2021.Methods Data from the Global Burden of Disease 2021 were analyzed for 204 countries and territories from 1990 to 2021. We explored the
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The history of biomarkers in psychiatry: lessons learned, lessons forgotten, lessons rediscovered Br. J. Psychiatry (IF 8.7) Pub Date : 2025-01-15 Michael Berk, Malcolm Forbes, Janardhanan Narayanaswamy
A quirky truth is that the oldest biomarker findings are largely metabolic. These had minimal impact on contemporary thought and research and were largely ignored. They have been rediscovered and validated almost 100 years later, informing our understanding of neurobiology and medical comorbidity and spurring contemporary treatment discovery efforts.
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Precision psychiatry: thinking beyond simple prediction models – enhancing causal predictions Br. J. Psychiatry (IF 8.7) Pub Date : 2025-01-15 Rajeev Krishnadas, Samuel P. Leighton, Peter B. Jones
Making informed clinical decisions based on individualised outcome predictions is the cornerstone of precision psychiatry. Prediction models currently employed in psychiatry rely on algorithms that map a statistical relationship between clinical features (predictors/risk factors) and subsequent clinical outcomes. They rely on associations that overlook the underlying causal structures within the data
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Self-harm in women in midlife: rates, precipitating problems and outcomes following hospital presentations in the multicentre study of self-harm in England Br. J. Psychiatry (IF 8.7) Pub Date : 2025-01-15 Caroline Clements, Harriet Bickley, Keith Hawton, Galit Geulayov, Keith Waters, Jennifer Ness, Samantha Kelly, Ellen Townsend, Louis Appleby, Nav Kapur
Background Suicide in women in the UK is highest among those in midlife. Given the unique changes in biological, social and economic risk factors experienced by women in midlife, more information is needed to inform care.Aim To investigate rates, characteristics and outcomes of self-harm in women in midlife compared to younger women and identify differences within the midlife age-group.Method Data
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Identifying genetic differences between bipolar disorder and major depression through multiple genome-wide association analyses Br. J. Psychiatry (IF 8.7) Pub Date : 2025-01-14 Georgia Panagiotaropoulou, Kajsa-Lotta Georgii Hellberg, Jonathan R. I. Coleman, Darsol Seok, Janos Kalman, the Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, the Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, the iPSYCH Study Consortium, Philip B. Mitchell, Peter R. Schofield, Andreas J. Forstner, Michael Bauer, Laura J. Scott, Carlos N. Pato
Background Accurate diagnosis of bipolar disorder (BPD) is difficult in clinical practice, with an average delay between symptom onset and diagnosis of about 7 years. A depressive episode often precedes the first manic episode, making it difficult to distinguish BPD from unipolar major depressive disorder (MDD).Aims We use genome-wide association analyses (GWAS) to identify differential genetic factors
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Antipsychotic continuation during pregnancy and risk of postpartum relapse in women with schizophrenia: nationwide register-based study Br. J. Psychiatry (IF 8.7) Pub Date : 2025-01-10 Sunghyuk Kang, Ji Su Yang, Bo Hyon Yun, Bizu Gelaye, Suk Kyoon An, Sun Jae Jung
Background Women with schizophrenia frequently discontinue antipsychotic medications during pregnancy. However, evidence on the risk of postpartum relapse associated with antipsychotic use during pregnancy is lacking.Aims To investigate the within-individual association between antipsychotic continuation during pregnancy and postpartum relapse in women with schizophrenia.Method This retrospective cohort
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Aberrant controllability of functional connectome during working memory tasks in patients with schizophrenia and unaffected siblings Br. J. Psychiatry (IF 8.7) Pub Date : 2025-01-07 Feiwen Wang, Zhening Liu, Ju Wang, Xiao Li, Yunzhi Pan, Jun Yang, Peng Cheng, Fuping Sun, Wenjian Tan, Danqing Huang, Jiamei Zhang, Xiawei Liu, Maoxing Zhong, Guowei Wu, Jie Yang, Lena Palaniyappan
Background Working memory deficit, a key feature of schizophrenia, is a heritable trait shared with unaffected siblings. It can be attributed to dysregulation in transitions from one brain state to another.Aims Using network control theory, we evaluate if defective brain state transitions underlie working memory deficits in schizophrenia.Method We examined average and modal controllability of the brain's
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Attitudes towards mental health professionals in social media: infodemiology study Br. J. Psychiatry (IF 8.7) Pub Date : 2025-01-07 Harriet Battle, Miguel Ángel Álvarez-Mon, Francisco J. Lara-Abelenda, Rafael Perez-Araluce, Mariana Pinto da Costa
Background Negative perceptions of mental health professionals can deter individuals from seeking mental healthcare. Given the high burden of mental health globally, it is essential to understand attitudes towards mental health professionals. Social media platforms like Twitter/X provide valuable insights into the views of the general population.Aims This study aimed to use social media to investigate
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Effect of ketamine on anxiety: findings from the Ketamine for Adult Depression Study Br. J. Psychiatry (IF 8.7) Pub Date : 2025-01-07 Natalie T Mills, Stevan Nikolin, Nick Glozier, David Barton, Bernhard T Baune, Paul B Fitzgerald, Paul Glue, Shanthi Sarma, Anthony Rodgers, Dusan Hadzi-Pavlovic, Angelo Alonzo, Vanessa Dong, Donel Martin, Philip B Mitchell, Michael Berk, Gregory Carter, Maree L Hackett, Andrew A. Somogyi, Cathrine Mihalopoulos, Mary Lou Chatterton, Sean Hood, Colleen K. Loo
Background Anxiety disorders and treatment-resistant major depressive disorder (TRD) are often comorbid. Studies suggest ketamine has anxiolytic and antidepressant properties.Aims To investigate if subcutaneous racemic ketamine, delivered twice weekly for 4 weeks, reduces anxiety in people with TRD.Method The Ketamine for Adult Depression Study was a multisite 4-week randomised, double-blind, active
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Self-harm in children and young people who die by suicide: UK-wide consecutive case series Br. J. Psychiatry (IF 8.7) Pub Date : 2025-01-06 Shilpa Aggarwal, Su-Gwan Tham, Saied Ibrahim, Pauline Turnbull, Roger T. Webb, Louis Appleby, Nav Kapur, Cathryn Rodway
Background An improved understanding of the factors associated with self-harm in young people who die by suicide can inform suicide prevention measures.Aims To describe sociodemographic and clinical characteristics and service utilisation related to self-harm in a national sample of young people who died by suicide.Method We carried out a descriptive study of self-harm in a national consecutive case
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Cost-effectiveness of ten commonly used antipsychotics in first-episode schizophrenia in the UK: economic evaluation based on a de novo discrete event simulation model Br. J. Psychiatry (IF 8.7) Pub Date : 2024-12-26 Junwen Zhou, Aurelie Millier, Samuel Aballea, Clement Francois, Huajin Jin, Ryan Williams, Belinda Lennox, Apostolos Tsiachristas, Mondher Toumi
Background Previous economic evidence about interventions for schizophrenia is outdated, non-transparent and/or limited to a specific clinical context.Aims We developed a de novo discrete event simulation (DES) model for estimating the cost-effectiveness of interventions in schizophrenia in the UK.Method The DES model was developed based on the structure of previous models, populated with demographic
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Triangulating evidence from the GALENOS living systematic review on trace amine-associated receptor 1 (TAAR1) agonists in psychosis Br. J. Psychiatry (IF 8.7) Pub Date : 2024-12-23 Katharine A. Smith, Niall Boyce, Astrid Chevance, Virginia Chiocchia, Christoph U. Correll, Kim Donoghue, Nikita Ghodke, Tatenda Kambeu, Gin S. Malhi, Malcolm Macleod, Lea Milligan, Jamie Morgan, Jennifer Potts, Emma S. J. Robinson, Spyridon Siafis, Iris E. C. Sommer, Bernhard Voelkl, Georgia Salanti, Andrea Cipriani, Julian P. T. Higgins
Background Trace amine-associated receptor 1 (TAAR1) agonists offer a new approach, but there is uncertainty regarding their effects, exact mechanism of action and potential role in treating psychosis.Aims To evaluate the available evidence on TAAR1 agonists in psychosis, using triangulation of the output of living systematic reviews (LSRs) of animal and human studies, and provide recommendations for
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Scaling up mental health interventions for people living with HIV in Zimbabwe: evidence for integration into differentiated service delivery programmes. Br. J. Psychiatry (IF 8.7) Pub Date : 2024-12-23 Walter Mangezi,Munyaradzi Mapingure,Tafadzwa Dzinamarira,Innocent Chingombe,Tatenda Makoni,Amon Mpofu,Godfrey Musuka
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The phenomenology within Cézanne's work: a reflection - Psychiatry in art. Br. J. Psychiatry (IF 8.7) Pub Date : 2024-12-23 João Martins-Correia
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Mythopsychopharmacology: definition and differential diagnosis - Miscellaneous. Br. J. Psychiatry (IF 8.7) Pub Date : 2024-12-23 George Ikkos,Dickon Bevington,Daniel McQueen,Daniel Shears
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Alias Grace - Psychiatry in television. Br. J. Psychiatry (IF 8.7) Pub Date : 2024-12-23 Katherine Elizabeth Witter
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Doughnut psychiatry as a living community model for sustainable development of children. Br. J. Psychiatry (IF 8.7) Pub Date : 2024-12-23 H Bruining,J Bakker
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The Patna Lunatic Asylum and Dr Hutchinson's lunar observations - Psychiatry in history. Br. J. Psychiatry (IF 8.7) Pub Date : 2024-12-23 Madhusudan Dalvi
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Prescribing of antipsychotics for people diagnosed with severe mental illness in UK primary care 2000–2019: 20-year investigation of who receives treatment, with which agents and at what doses Br. J. Psychiatry (IF 8.7) Pub Date : 2024-12-18 Alvin Richards-Belle, Naomi Launders, Sarah Hardoon, Kenneth K.C. Man, Elvira Bramon, David P.J. Osborn, Joseph F. Hayes
Background Contemporary data relating to antipsychotic prescribing in UK primary care for patients diagnosed with severe mental illness (SMI) are lacking.Aims To describe contemporary patterns of antipsychotic prescribing in UK primary care for patients diagnosed with SMI.Method Cohort study of patients with an SMI diagnosis (i.e. schizophrenia, bipolar disorder, other non-organic psychoses) first
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Improving dementia prognostication in cognitively normal older adults: conventional versus novel approaches to modelling risk associated with neuropsychiatric symptoms Br. J. Psychiatry (IF 8.7) Pub Date : 2024-12-16 Maryam Ghahremani, Eric E. Smith, Zahinoor Ismail
Background Studies in cognitively normal individuals on associations between psychiatric symptomatology and incident dementia have not reliably differentiated psychiatric syndromes from neuropsychiatric symptoms (NPS) that represent neurodegeneration. Conventional modelling often overlooks symptom natural history. Mild behavioural impairment (MBI) is a syndrome that leverages later-life emergent and
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Unravelling Stendhal syndrome: the intersection of art, emotion and neuroscience Br. J. Psychiatry (IF 8.7) Pub Date : 2024-12-11 Lien-Chung Wei
Stendhal syndrome represents a compelling psychosomatic response, characterised by intense emotional and physiological reactions to viewing art, that intersects the fields of psychiatry, neurology and aesthetics. Despite lacking formal diagnostic recognition, a confluence of historical anecdotes and contemporary research underscores its validity as a unique neuropsychiatric phenomenon. This review
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Transient patterns of advanced brain ageing in female adolescents with anorexia nervosa Br. J. Psychiatry (IF 8.7) Pub Date : 2024-12-11 Tatiana Stratton, Klaas Bahnsen, Daniel Geisler, Fabio Bernardoni, Christian Gaser, Stefan Ehrlich, Esther Walton
Background Anorexia nervosa is a psychiatric disorder characterised by undernutrition, significantly low body weight and large, although possibly transient, reductions in brain structure. Advanced brain ageing tracks accelerated age-related changes in brain morphology that have been linked to psychopathology and adverse clinical outcomes.Aim The aim of the current case–control study was to characterise
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Efficacy and safety of a 4-week course of repeated subcutaneous ketamine injections for treatment-resistant depression (KADS study): commentary, Joks et al Br. J. Psychiatry (IF 8.7) Pub Date : 2024-12-11 Gero Joks, Steve Su, Jarrad King
Regarding the article, ‘Efficacy and safety of a 4-week course of repeated subcutaneous ketamine injections for treatment-resistant depression (KADS study): randomised double-blind active-controlled trial’, we commend Loo et al1 for undertaking the Ketamine for Adult Depression Study (KADS). In the interest of ensuring that accurate and balanced information is presented to healthcare professionals
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Early antibiotic exposure and risk of psychiatric and neurocognitive outcomes: systematic review and meta-analysis Br. J. Psychiatry (IF 8.7) Pub Date : 2024-12-11 Jessica Emily Green, Anna Wrobel, Emma Todd, Wolfgang Marx, Michael Berk, Mojtaba Lotfaliany, David Castle, John F. Cryan, Eugene Athan, Christopher Hair, Andrew A. Nierenberg, Felice N. Jacka, Samantha Dawson
Background The prenatal and early-life periods pose a crucial neurodevelopmental window whereby disruptions to the intestinal microbiota and the developing brain may have adverse impacts. As antibiotics affect the human intestinal microbiome, it follows that early-life antibiotic exposure may be associated with later-life psychiatric or neurocognitive outcomes.Aims To explore the association between
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Personality disorders, violence and antisocial behaviour: updated systematic review and meta-regression analysis Br. J. Psychiatry (IF 8.7) Pub Date : 2024-12-11 Rachel T.S. Chow, Rongqin Yu, John R. Geddes, Seena Fazel
Background Links between personality disorders and antisocial outcomes has not examined individual personality disorders, and the contribution of comorbidities remain uncertain. Previous systematic reviews are dated.Aims To synthesise evidence from observational studies on the risk of antisocial outcomes and recidivism associated with personality disorders.Method We searched six bibliographic databases
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Violence and schizophrenia: let us take a deep breath and gain a meta-perspective. Br. J. Psychiatry (IF 8.7) Pub Date : 2024-12-11 Natalia Tesli,Anja Vaskinn
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Inside Out 2: the adolescent mind and the role of anxiety - Psychiatry in movies. Br. J. Psychiatry (IF 8.7) Pub Date : 2024-12-11 Harry Barker
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Dyce Sombre - Psychiatry in history. Br. J. Psychiatry (IF 8.7) Pub Date : 2024-12-11 Chaitanya V Haldipur
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Psychiatry in children's literature: guess how much I hate you - Extra. Br. J. Psychiatry (IF 8.7) Pub Date : 2024-12-11 Frederick Arthur Jack Simon
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Divinities of suicide in ancient mythologies - Psychiatry in sacred texts. Br. J. Psychiatry (IF 8.7) Pub Date : 2024-12-11 Luca Cambioli,Michele Augusto Riva
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Ethnic inequalities in involuntary admission under the Mental Health Act: commentary, Coid. Br. J. Psychiatry (IF 8.7) Pub Date : 2024-12-11 Jeremy Coid
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The Velvet Underground's performance for the New York Society for Clinical Psychiatry in 1966 - Psychiatry in music. Br. J. Psychiatry (IF 8.7) Pub Date : 2024-12-11 Nicholas Griffin,Alexander Smith,Michael Liebrenz
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Exceptional racism at the dawn of scientific psychiatry in Brazil: the curious case of Juliano Moreira: commentary. Br. J. Psychiatry (IF 8.7) Pub Date : 2024-12-11 Peter Tyrer
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Portable ultra-low-field MRI: scanning new horizons in dementia detection. Br. J. Psychiatry (IF 8.7) Pub Date : 2024-12-11 Joanne Rodda,James Dobrzanski,Sukhi Shergill
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Mental health classifications in primary care: commentary, Dowrick. Br. J. Psychiatry (IF 8.7) Pub Date : 2024-12-11 Christopher Dowrick
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Genetic identification of undiagnosed benign ethnic neutropenia in patients receiving clozapine treatment Br. J. Psychiatry (IF 8.7) Pub Date : 2024-12-09 Helena Aziri, Kalliopi Vallianatou, Bhirundra Balgobin, David Taylor
Background Clozapine therapy presents a risk of agranulocytosis, necessitating monitoring of white blood cell count. The detection of benign ethnic neutropenia (BEN), in which neutropenia can be present without an increased risk of infection, is particularly important in preventing unnecessary withdrawal of clozapine. BEN is strongly linked to the CC homozygote of the single nucleotide polymorphism
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Personality disorders Br. J. Psychiatry (IF 8.7) Pub Date : 2024-12-09 Roger T. Mulder
An overview of changes in the classification of personality disorders from ICD-10 to ICD-11 is presented. The new classification incorporates a dimensional approach centred on severity with five domains available to describe personality pathology. The potential clinical utility of the new approach is discussed.
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Consistent evidence that brain serotonin 2A receptor binding is positively associated with personality-based risk markers of depression Br. J. Psychiatry (IF 8.7) Pub Date : 2024-12-05 Emma S. Høgsted, Vincent Beliveau, Brice Ozenne, Martin K. Madsen, Claus Svarer, Vibeke H. Dam, Annette Johansen, Patrick Fisher, Gitte M. Knudsen, Vibe G. Frokjaer, Anjali Sankar
Background Using [18F]altanserin, a serotonin 2A receptor (5-HT2AR) antagonist Positron Emission Tomography (PET) tracer, a positive association between cortical 5-HT2AR binding and the inward-directed facets of neuroticism has been demonstrated in healthy individuals. Psilocybin, a 5-HT2AR agonist, shows promise for the treatment of depression, reducing neuroticism and mood symptoms potentially via
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Real-world effects of antidepressants for depressive disorder in primary care: population-based cohort study Br. J. Psychiatry (IF 8.7) Pub Date : 2024-12-05 Franco De Crescenzo, Riccardo De Giorgi, Cesar Garriga, Qiang Liu, Seena Fazel, Orestis Efthimiou, Julia Hippisley-Cox, Andrea Cipriani
Background Antidepressants’ effects are established in randomised controlled trials (RCTs), but not in the real world.Aims To investigate real-world comparative effects of antidepressants for depression and compare them with RCTs.Method We performed a cohort study based on the QResearch database. We included people with a newly recorded diagnosis of depression, exposed to licensed antidepressants in
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Time-out under scrutiny: examining the relationships among the discipline strategy time-out, child well-being and attachment and exposure to adversity Br. J. Psychiatry (IF 8.7) Pub Date : 2024-12-05 Alex Roach, Rebecca McLean, Antonio Mendoza Diaz, David Hawes, Mark Dadds
Background Discipline is a crucial aspect of parenting, shaping child development and behaviour. Time-out, a widely used disciplinary strategy with a strong evidence-base, has recently come under scrutiny with concerns about potential adverse effects on children's emotional development and attachment, particularly for those with a history of adversity.Aims To contribute critical empirical insights
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Accelerometer-derived movement behaviours and risk of mortality among individuals with pre-existing depression: prospective cohort study Br. J. Psychiatry (IF 8.7) Pub Date : 2024-12-04 Tingshan Duan, Zhi Cao, Xuemei Wang, Jiahao Min, Tao Sun, Hong Luo, Chenjie Xu
Background Evidence is largely limited regarding the extent to which abnormal behavioural profiles, including physical inactivity, sedentary behaviour and inadequate sleep duration, impact long-term health conditions in individuals with pre-existing depression.Aims To investigate the associations between accelerometer-derived daily movement behaviours and mortality in individuals with pre-existing
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The changing doctor–patient relationship in psychiatry: observations on recent trends in autism, attention-deficit hyperactivity disorder, gender dysphoria and mental distress Br. J. Psychiatry (IF 8.7) Pub Date : 2024-12-04 Ben Beaglehole, Bridgette Thwaites, Bess Kew, Roger Mulder
This editorial highlights increasing prevalence and treatment rates of apparently disparate disorders. We ask whether cross-disorder factors including greater mental health literacy, social media and a shift to psychiatric explanations for distress contribute to these trends. We highlight a consequence: the changing doctor–patient relationship and its impacts.
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Intervening early across the lifespan: going beyond youth-focused psychosis care to meet the needs of women Br. J. Psychiatry (IF 8.7) Pub Date : 2024-12-04 Sean Naughton, Grainne McGinty, Niall Duffy, David Marshall, Judith Corrigan, Mary Clarke
Psychotic disorders have sex-specific differences in their onset, symptoms and course. The early intervention in psychosis model represented the first step toward personalised psychosis care, recognising stage-specific care needs. Incorporating knowledge about sex-specific differences in care programmes should be the next evolution of personalised psychosis care.
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Parsing stigma's relationship with the psychosocial functioning of youth identified as at clinical high risk for psychosis: evaluating whether symptom stigma or labelling stigma is stronger Br. J. Psychiatry (IF 8.7) Pub Date : 2024-12-04 Lawrence H. Yang, Margaux M. Grivel, Drew Blasco, Ragy R. Girgis, Debbie Huang, Kristen A. Woodberry, Cheryl M. Corcoran, William R. McFarlane, Bruce G. Link
Background The clinical high risk for psychosis (CHR-p) syndrome enables early identification of individuals at risk of schizophrenia and related disorders. We differentiate between the stigma associated with the at-risk identification itself (‘labelling-related’ stigma) versus stigma attributed to experiencing mental health symptoms (‘symptom-related’ stigma) and examine their relationships with key