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BMAL1 and HIF2α are key regulators of circadian-dependent variations in myocardial injury Nat. Rev. Cardiol. (IF 41.7) Pub Date : 2025-05-12 Karina Huynh
A new study published in Nature reveals the role of the interaction between the circadian transcription factor BMAL1 and hypoxia-inducible factor 2α in circadian-dependent cardioprotection after ischaemia–reperfusion injury, and highlights the potential of chronotherapeutic approaches for ischaemic heart disease.
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Endothelial cell metabolism in cardiovascular physiology and disease Nat. Rev. Cardiol. (IF 41.7) Pub Date : 2025-05-09 Alessandra Pasut, Eleonora Lama, Amaryllis H. Van Craenenbroeck, Jeffrey Kroon, Peter Carmeliet
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Social media in modern cardiology: a tool for building community, visibility and impact Nat. Rev. Cardiol. (IF 41.7) Pub Date : 2025-05-08 Ritu Thamman, Rafael Vidal-Perez
Digital communication increasingly shapes early-career cardiology. Social media offers powerful tools for education, networking and career growth, but also poses challenges such as misinformation and lack of professionalism. In this Comment article, we outline practical strategies for effectively navigating social media in the early stages of a cardiology career.
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Redefining respiratory sinus arrhythmia as respiratory heart rate variability: an international Expert Recommendation for terminological clarity Nat. Rev. Cardiol. (IF 41.7) Pub Date : 2025-05-06 Clément Menuet, Alona Ben-Tal, Ambre Linossier, Andrew M. Allen, Benedito H. Machado, Davi J. A. Moraes, David G. S. Farmer, David J. Paterson, David Mendelowitz, Edward G. Lakatta, Edwin W. Taylor, Gareth L. Ackland, Irving H. Zucker, James P. Fisher, James S. Schwaber, Julia Shanks, Julian F. R. Paton, Julie Buron, K. Michael Spyer, Kalyanam Shivkumar, Mathias Dutschmann, Michael J. Joyner, Neil
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Decongestion in heart failure: medical and device therapies Nat. Rev. Cardiol. (IF 41.7) Pub Date : 2025-04-28 Zachary L. Cox, Kevin Damman, Jeffrey M. Testani
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Sotatercept as add-on therapy for advanced PAH Nat. Rev. Cardiol. (IF 41.7) Pub Date : 2025-04-22 Xiulin Köhler
Sotatercept, an activin-signalling inhibitor, is a promising add-on treatment for patients with advanced pulmonary arterial hypertension and a high risk of death, according to data from the ZENITH trial.
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Pulsed field ablation non-inferior to cryoablation for paroxysmal AF Nat. Rev. Cardiol. (IF 41.7) Pub Date : 2025-04-16 Irene Fernández-Ruiz
In patients with symptomatic paroxysmal atrial fibrillation, pulsed field ablation is non-inferior to cryoballoon ablation for preventing the recurrence of atrial tachyarrhythmia, according to findings from the SINGLE SHOT CHAMPION trial.
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Expanding cardiovascular indications for semaglutide: results from the SOUL and STRIDE trials Nat. Rev. Cardiol. (IF 41.7) Pub Date : 2025-04-14 Karina Huynh
Two clinical trials presented at the ACC.25 describe the expanding indications for the glucagon-like peptide 1 receptor agonist semaglutide in patients with type 2 diabetes mellitus.
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Post-translational acylation of proteins in cardiac hypertrophy Nat. Rev. Cardiol. (IF 41.7) Pub Date : 2025-04-14 Ying-Qi Liu, Qin Yang, Guo-Wei He
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No effect of cerebral embolic protection devices on stroke risk after TAVI Nat. Rev. Cardiol. (IF 41.7) Pub Date : 2025-04-10 Irene Fernández-Ruiz
Findings from the BHF PROTECT-TAVI trial indicate that the routine use of cerebral embolic protection devices during transcatheter aortic valve implantation does not decrease the incidence of stroke within 72 h after the intervention.
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Development of a miniature, bioresorbable, light-activated pacemaker Nat. Rev. Cardiol. (IF 41.7) Pub Date : 2025-04-10 Gregory B. Lim
Researchers have engineered a millimetre-scale, bioresorbable, optoelectronic system that can be minimally invasively implanted into the heart and wirelessly controlled by a light source on the surface of the skin to provide temporary cardiac pacing.
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Apolipoprotein B100 revisited Nat. Rev. Cardiol. (IF 41.7) Pub Date : 2025-04-10 Mia S. Manojlovic, Melaku Taye Amogne
Mia Manojlovic and Melaku Taye Amogne highlight the 1986 study that unravelled the primary structure of apolipoprotein B100 and laid a foundation for subsequent studies on the role of this apolipoprotein.
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Primordial prevention of cardiovascular disease Nat. Rev. Cardiol. (IF 41.7) Pub Date : 2025-04-08 Hooi Min Lim
Hooi Min Lim describes how the Bogalusa Heart Study emphasized the importance of primordial prevention of cardiovascular disease and profoundly influenced subsequent cardiovascular research on children and adolescents.
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A turning point in cardiac remodelling in obesity Nat. Rev. Cardiol. (IF 41.7) Pub Date : 2025-04-07 Mariella R. Huaman, Carlos J. Toro-Huamanchumo
Mariella Huaman and Carlos Toro-Huamanchumo discuss the 2013 study that provided crucial insights into the cardiac structural changes associated with obesity and challenged previously established paradigms.
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Molecular gatekeepers of endogenous adult mammalian cardiomyocyte proliferation Nat. Rev. Cardiol. (IF 41.7) Pub Date : 2025-04-07 Tim Koopmans, Eva van Rooij
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Preserving the future of heart transplantation Nat. Rev. Cardiol. (IF 41.7) Pub Date : 2025-04-04 David M. Kaye, David C. McGiffin
Heart transplantation remains the optimal long-term treatment for appropriate patients with advanced heart failure. However, the donor heart shortage is a limiting factor, and the risk profile of transplant candidates is worsening. In this landscape, the utility of conventional cold static storage for donor hearts is increasingly limited. In this Clinical Outlook, we discuss new methods of donor heart
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Clonal haematopoiesis in cardiovascular disease: prognostic role and novel therapeutic target Nat. Rev. Cardiol. (IF 41.7) Pub Date : 2025-04-02 Art Schuermans, Michael C. Honigberg
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Tunnelling nanotube-like structures facilitate cell–cell communication during heart development Nat. Rev. Cardiol. (IF 41.7) Pub Date : 2025-04-02 Karina Huynh
A new study reports the presence of tunnelling nanotube-like structures in mouse embryonic hearts that have a crucial role in facilitating long-distance cell–cell communication during early heart morphogenesis.
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Factor XI inhibitors for the prevention and treatment of venous and arterial thromboembolism Nat. Rev. Cardiol. (IF 41.7) Pub Date : 2025-03-31 Davide Capodanno, John H. Alexander, M. Cecilia Bahit, John W. Eikelboom, C. Michael Gibson, Shaun G. Goodman, Vijay Kunadian, Gregory Y. H. Lip, Renato D. Lopes, Roxana Mehran, Shamir R. Mehta, Manesh R. Patel, Jonathan P. Piccini, Sunil V. Rao, Christian T. Ruff, P. Gabriel Steg, Jeffrey I. Weitz, Dominick J. Angiolillo
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Scientific journey from PSCK9 discovery in familial hypercholesterolaemia Nat. Rev. Cardiol. (IF 41.7) Pub Date : 2025-03-28 Marianne Abifadel
Countries globally face major challenges in the early diagnosis and treatment of hypercholesterolaemia and cardiovascular disease, with numerous health inequities by geography and income. Perseverance, hard work, integrity and commitment can transform aspiration into reality. My PCSK9 story, from the discovery of its implication in familial hypercholesterolemia to the development of life-saving drugs
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Ceramides aggravate atherosclerosis via G protein-coupled receptor signalling Nat. Rev. Cardiol. (IF 41.7) Pub Date : 2025-03-26 Irene Fernández-Ruiz
A study published in Nature has identified two transmembrane G protein-coupled receptors that mediate extracellular-to-intracellular ceramide signalling and shows that blocking these receptors alleviates the atherosclerosis that is induced by a high-fat diet or aggravated by chronic kidney disease in mice.
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Mitochondrial quality control in cardiomyocytes: safeguarding the heart against disease and ageing Nat. Rev. Cardiol. (IF 41.7) Pub Date : 2025-03-20 Rishith Ravindran, Åsa B. Gustafsson
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Extracellular vesicles in cardiovascular homeostasis and disease: potential role in diagnosis and therapy Nat. Rev. Cardiol. (IF 41.7) Pub Date : 2025-03-05 Junjie Xiao, Joost P. G. Sluijter
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The brain–heart axis: integrative cooperation of neural, mechanical and biochemical pathways Nat. Rev. Cardiol. (IF 41.7) Pub Date : 2025-03-03 Gaetano Valenza, Zoran Matić, Vincenzo Catrambone
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Epigenetic editing in cardiovascular medicine: moving beyond the hype Nat. Rev. Cardiol. (IF 41.7) Pub Date : 2025-02-28 Luca Chiapperino, Michelle Habets, Francesco Paneni
Epigenetic editing holds great promise for the treatment of many diseases, including cardiovascular disease. However, realizing this potential requires more than developing robust technology and demands a steadfast focus on patient needs and inclusion, to ensure that access to epigenetic medicine will be equitable and will benefit diverse populations worldwide.
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Endomyocardial fibrosis: recent advances and future therapeutic targets Nat. Rev. Cardiol. (IF 41.7) Pub Date : 2025-02-26 Ana O. Mocumbi, Viviane Tiemi Hotta, Gene Bukhman, Ntobeko Ntusi, Magdi H. Yacoub, Paulo Correia-de-Sá
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Salt sensitivity of blood pressure: mechanisms and sex-specific differences Nat. Rev. Cardiol. (IF 41.7) Pub Date : 2025-02-21 Sepiso K. Masenga, Nelson Wandira, Giuliana Cattivelli-Murdoch, Mohammad Saleem, Heather Beasley, Antentor Hinton, Lale A. Ertuglu, Naome Mwesigwa, Thomas R. Kleyman, Annet Kirabo
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Roadmap for alleviating the manifestations of ageing in the cardiovascular system Nat. Rev. Cardiol. (IF 41.7) Pub Date : 2025-02-19 Luca Liberale, Simon Tual-Chalot, Simon Sedej, Stefano Ministrini, Georgios Georgiopoulos, Myriam Grunewald, Magnus Bäck, Marie-Luce Bochaton-Piallat, Reinier A. Boon, Gustavo Campos Ramos, Menno P. J. de Winther, Konstantinos Drosatos, Paul C. Evans, Jane F. Ferguson, Sofia K. Forslund-Startceva, Claudia Goettsch, Mauro Giacca, Judith Haendeler, Marinos Kallikourdis, Daniel F. J. Ketelhuth, Rory R
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Wearable blood pressure sensors for cardiovascular monitoring and machine learning algorithms for blood pressure estimation Nat. Rev. Cardiol. (IF 41.7) Pub Date : 2025-02-18 Seongwook Min, Jaehun An, Jae Hee Lee, Ji Hoon Kim, Daniel J. Joe, Soo Hwan Eom, Chang D. Yoo, Hyo-Suk Ahn, Jin-Young Hwang, Sheng Xu, John A. Rogers, Keon Jae Lee
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Clinical implications of perioperative and periprocedural myocardial infarction Nat. Rev. Cardiol. (IF 41.7) Pub Date : 2025-02-12 Konstantin A. Krychtiuk, Christopher B. Granger, Bernard J. Gersh
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Author Correction: Traction force microscopy of cardiomyocytes Nat. Rev. Cardiol. (IF 41.7) Pub Date : 2025-02-11 Maia Lyall
Correction to: Nature Reviews Cardiology https://doi.org/10.1038/s41569-025-01123-4, published online 21 January 2025.
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Remuscularizing the failing heart in primates Nat. Rev. Cardiol. (IF 41.7) Pub Date : 2025-02-10 Gregory B. Lim
Tissue engineered heart muscle implanted on to the epicardium can structurally and functionally remuscularize the failing hearts of rhesus macaques, with no major adverse effects; a clinical trial of this approach is now underway in patients with heart failure.
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Tracing the roots of cardiac fibrosis: role of endothelial-to-mesenchymal transition Nat. Rev. Cardiol. (IF 41.7) Pub Date : 2025-02-07 Elizabeth Figueroa-Juárez
Elizabeth Figueroa-Juárez describes the study that demonstrated that fibroblasts derived from endothelial cells through endothelial-to-mesenchymal transition contribute to cardiac fibrosis.
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Novel pharmacological approaches to lowering blood pressure and managing hypertension Nat. Rev. Cardiol. (IF 41.7) Pub Date : 2025-02-07 Matthew Sayer, David J. Webb, Neeraj Dhaun
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Vagal circuits in the heart and gut can regulate cardiometabolism and stress responses Nat. Rev. Cardiol. (IF 41.7) Pub Date : 2025-02-07 Karina Huynh
A new study shows that activation of vagal sensory neurons expressing the oxytocin receptor in the cardiovascular and gastrointestinal tissues of mice mediates cardiometabolic changes resembling those from a hibernation-like, hypometabolic state.
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Predictive cardio-omics: translating single-cell multiomics into tools for personalized medicine Nat. Rev. Cardiol. (IF 41.7) Pub Date : 2025-02-03 Kami Pekayvaz, Matthias Heinig, Konstantin Stark
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Anthracycline-induced cardiomyopathy: risk prediction, prevention and treatment Nat. Rev. Cardiol. (IF 41.7) Pub Date : 2025-01-28 Iacopo Fabiani, Michela Chianca, Carlo Maria Cipolla, Daniela Maria Cardinale
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Colchicine in acute coronary syndromes: the present and the possible future Nat. Rev. Cardiol. (IF 41.7) Pub Date : 2025-01-28 Massimo Imazio, Federico Ballacci, Federica Giordano
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Obesity alters cholesterol homeostasis in regulatory T cells of visceral adipose tissue Nat. Rev. Cardiol. (IF 41.7) Pub Date : 2025-01-28 Irene Fernández-Ruiz
A new study shows how obesity can disrupt a cholesterol metabolism in a particular subset of metabolically protective regulatory T cells in visceral adipose tissue.
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The molecular structure of LDL has finally been elucidated Nat. Rev. Cardiol. (IF 41.7) Pub Date : 2025-01-28 Gilles C. Lambert, Simon G. Pfisterer
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The relationship between cannabis and cardiovascular disease: clearing the haze Nat. Rev. Cardiol. (IF 41.7) Pub Date : 2025-01-23 Mark Chandy, Nerea Jimenez-Tellez, Joseph C. Wu
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AI-driven evolution of precision population cardiovascular health in cities Nat. Rev. Cardiol. (IF 41.7) Pub Date : 2025-01-21 Ann Aerts, Michelle A. Williams
New research shows how the social determinants of cardiovascular health vary locally within cities. Artificial intelligence makes it possible to quantify the relative importance of these social determinants at a hyper-local level, which can inform interventions. To realize these opportunities, new partnership models are needed that pay special attention to data quality and governance.
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Traction force microscopy of cardiomyocytes Nat. Rev. Cardiol. (IF 41.7) Pub Date : 2025-01-21 Maia Lyall
In this Tools of the Trade article, Lyall discusses the use of traction force microscopy to assess the contractile function of individual cardiomyocytes.
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Interventions for adult congenital heart disease Nat. Rev. Cardiol. (IF 41.7) Pub Date : 2025-01-20 Pedro Cepas-Guillén, Eduardo Flores-Umanzor, Eric Horlick, Jamil Aboulhosn, Lee Benson, Xavier Freixa, Christine Houde, Josep Rodés-Cabau
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Mind the gap: sex-related differences in cardiovascular disease Nat. Rev. Cardiol. (IF 41.7) Pub Date : 2025-01-14 Anju Loveridge
Anju Loveridge discusses the Framingham Heart Study report that described the link between diabetes mellitus and cardiovascular disease as well as sex-related differences in cardiovascular disease.
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Effective CRISPR modulation of complex non-coding RNA loci Nat. Rev. Cardiol. (IF 41.7) Pub Date : 2025-01-14 Francesca Vacante, Andrew H. Baker
In this Tools of the Trade article, Francesca Vacante and Andrew Baker describe a CRISPR-based approach to target the regulatory regions of non-coding RNAs.
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Engineering extracellular vesicles for therapeutic delivery in ischaemic stroke Nat. Rev. Cardiol. (IF 41.7) Pub Date : 2025-01-14 Lara Anne Birch
In this Tools of the Trade article, Birch describes how extracellular vesicles can be engineered to deliver therapeutic microRNAs for the treatment of ischaemic stroke.
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Cardiac optogenetics: controlling the heart with light Nat. Rev. Cardiol. (IF 41.7) Pub Date : 2025-01-13 Sasha B. Forbes
Sasha Forbes discusses the study that demonstrated that the electrical activity of the heart could be regulated with light with the use of optogenetics.
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Atherosclerosis in diabetes mellitus: novel mechanisms and mechanism-based therapeutic approaches Nat. Rev. Cardiol. (IF 41.7) Pub Date : 2025-01-13 Abdul Waheed Khan, Karin A. M. Jandeleit-Dahm
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The rapid delayed-rectifier potassium current: a biophysical basis for cardiac repolarization and arrhythmia Nat. Rev. Cardiol. (IF 41.7) Pub Date : 2025-01-10 Joseph E. Carr
Joseph Carr highlights the study that described the rapid component of the delayed-rectifier potassium current and laid the groundwork for later studies into the fundamental biophysics of ion channels.
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The spleen in ischaemic heart disease Nat. Rev. Cardiol. (IF 41.7) Pub Date : 2025-01-02 Gerd Heusch, Petra Kleinbongard
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Extracellular matrix in vascular homeostasis and disease Nat. Rev. Cardiol. (IF 41.7) Pub Date : 2025-01-02 Lu Zhang, Jing Zhou, Wei Kong
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Phenotyping atherosclerotic plaque and perivascular adipose tissue: signalling pathways and clinical biomarkers in atherosclerosis Nat. Rev. Cardiol. (IF 41.7) Pub Date : 2025-01-02 Kajetan Grodecki, Jolien Geers, Jacek Kwiecinski, Andrew Lin, Leandro Slipczuk, Piotr J. Slomka, Marc R. Dweck, Nitesh Nerlekar, Michelle C. Williams, Daniel Berman, Thomas Marwick, David E. Newby, Damini Dey
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Haematometabolism rewiring in atherosclerotic cardiovascular disease Nat. Rev. Cardiol. (IF 41.7) Pub Date : 2025-01-02 Laurent Yvan-Charvet, Thibault Barouillet, Coraline Borowczyk
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Apolipoprotein B-containing lipoproteins in atherogenesis Nat. Rev. Cardiol. (IF 41.7) Pub Date : 2025-01-02 Jan Borén, Chris J. Packard, Christoph J. Binder
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Renal denervation for hypertension Nat. Rev. Cardiol. (IF 41.7) Pub Date : 2025-01-02 Naomi D. L. Fisher, Ajay J. Kirtane
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Functional diversity of cardiac macrophages in health and disease Nat. Rev. Cardiol. (IF 41.7) Pub Date : 2025-01-02 Steven Yang, Vinay Penna, Kory J. Lavine
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Targeting macrophage–fibroblast interactions in the failing heart Nat. Rev. Cardiol. (IF 41.7) Pub Date : 2024-12-16 Nikolaos G. Frangogiannis
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Left atrial appendage closure after ablation: the best OPTION for patients with AF? Nat. Rev. Cardiol. (IF 41.7) Pub Date : 2024-12-11 Karina Huynh
Two studies presented at AHA 2024 Scientific Sessions describe the efficacy and safety of left atrial appendage closure after catheter ablation for atrial fibrillation and the 5-year outcomes of the largest randomized left atrial appendage closure trial to date comparing the safety and efficacy of two devices.
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Pro-arrhythmic potential of proton-pump inhibitors Nat. Rev. Cardiol. (IF 41.7) Pub Date : 2024-12-09 Pietro Enea Lazzerini, Riccardo Accioli, Pier Leopoldo Capecchi, Maurizio Acampa
Population studies have reported that proton-pump inhibitors (PPIs) increase cardiovascular mortality, at least in part owing to an increased propensity for life-threatening arrhythmias, but these findings have largely been ignored. We propose a series of recommendations for prescribers of PPIs to ensure a balance of the benefits against the potential arrhythmic risks.