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Temporary Mechanical Cardiac Support Outcomes and Cardiogenic Shock-Reply. JAMA Cardiol. (IF 14.8) Pub Date : 2025-04-16 Jacob Eifer Møller,Nanna Louise Junker Udesen,Christian Hassager
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Temporary Mechanical Cardiac Support Outcomes and Cardiogenic Shock. JAMA Cardiol. (IF 14.8) Pub Date : 2025-04-16 Federico Pappalardo,Nicoletta D'Ettore,Andrea Montisci
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Artificial Intelligence–Enabled Prediction of Heart Failure Risk From Single-Lead Electrocardiograms JAMA Cardiol. (IF 14.8) Pub Date : 2025-04-16 Lovedeep S. Dhingra, Arya Aminorroaya, Aline F. Pedroso, Akshay Khunte, Veer Sangha, Daniel McIntyre, Clara K. Chow, Folkert W. Asselbergs, Luisa C. C. Brant, Sandhi M. Barreto, Antonio Luiz P. Ribeiro, Harlan M. Krumholz, Evangelos K. Oikonomou, Rohan Khera
ImportanceDespite the availability of disease-modifying therapies, scalable strategies for heart failure (HF) risk stratification remain elusive. Portable devices capable of recording single-lead electrocardiograms (ECGs) may enable large-scale community-based risk assessment.ObjectiveTo evaluate whether an artificial intelligence (AI) algorithm can predict HF risk from noisy single-lead ECGs.Design
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Automated Deep Learning Phenotyping of Tricuspid Regurgitation in Echocardiography JAMA Cardiol. (IF 14.8) Pub Date : 2025-04-16 Amey Vrudhula, Milos Vukadinovic, Christiane Haeffele, Alan C. Kwan, Daniel Berman, David Liang, Robert Siegel, Susan Cheng, David Ouyang
ImportanceAccurate assessment of tricuspid regurgitation (TR) is necessary for identification and risk stratification.ObjectiveTo design a deep learning computer vision workflow for identifying color Doppler echocardiogram videos and characterizing TR severity.Design, Setting, and ParticipantsAn automated deep learning workflow was developed using 47 312 studies (2 079 898 videos) from Cedars-Sinai
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Periconceptional Glucagon-Like Peptide-1 Receptor Agonist Use and Discontinuation JAMA Cardiol. (IF 14.8) Pub Date : 2025-04-16 Sadiya S. Khan, William A. Grobman, Dhruv S. Kazi
This Viewpoint describes the need for more studies on the best timing for dicontinuation of glucagon-like peptide-1 receptor agonists before pregnancy.
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Progressive Kidney Dysfunction After Left Atrial Appendage Closure. JAMA Cardiol. (IF 14.8) Pub Date : 2025-04-09 Shuaishuai Yuan,Chao Tao,Peijun Li
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Self-Administered Etripamil and Emergency Department Visits in Supraventricular Tachycardia JAMA Cardiol. (IF 14.8) Pub Date : 2025-04-09 Sean D. Pokorney, A. John Camm, Paul Dorian, James E. Ip, Bruce S. Stambler, David B. Bharucha, Jonathan P. Piccini
This secondary analysis of a randomized clinical trial describes the use of emergency care after self-administration of etripamil by patients experiencing paroxysmal supraventricular tachycardia episodes at home.
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Accountable Care Organization Participation and Cardiovascular Care Quality JAMA Cardiol. (IF 14.8) Pub Date : 2025-04-04 Erica S. Spatz, D. August Oddleifson, Jehanzeb Kayani, Kensey L. Gosch, Philip G. Jones, Rushabh H. Doshi, Thomas M. Maddox, Nihar R. Desai
ImportanceThe Medicare Shared Savings Program (MSSP) was introduced in 2012 to improve care quality and lower costs to Medicare. Under this program, accountable care organizations (ACOs) assumed responsibility for costs and care quality for a group of Medicare beneficiaries.ObjectiveTo compare changes in quality measures for patients at outpatient cardiology practices before and after their participation
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Hypertensive Disorders of Pregnancy and Long-Term Risk of Dilated Cardiomyopathy JAMA Cardiol. (IF 14.8) Pub Date : 2025-04-04 Upasana Tayal, Constantinos Kallis, Georgie M. Massen, Nora Rossberg, Emily L. Graul, Jennifer K. Quint
ImportanceThe impact of hypertensive disorders of pregnancy on developing dilated cardiomyopathy is unknown.ObjectiveTo determine whether hypertensive disorders of pregnancy are associated with long-term risk of dilated cardiomyopathy.Design, Setting, and ParticipantsThis population-based cohort study performed in England used the following linked electronic health records databases: Clinical Practice
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Adverse Pregnancy Outcomes and N-Terminal Pro-Brain Natriuretic Peptide Levels 2 to 7 Years After Delivery: The nuMoM2b Heart Health Study. JAMA Cardiol. (IF 14.8) Pub Date : 2025-04-02 Priya M Freaney,Xiaoning Huang,Lucia C Petito,William A Grobman,Janet Catov,Alisse Hauspurg,C Noel Bairey Merz,Natalie Bello,Jin Kyung Kim,Abbi Lane,David M Haas,Lisa D Levine,Rebecca B McNeil,Eliza Miller,George Saade,Lauren Theilen,Lynn M Yee,Jasmina Varagic,Brian Mercer,Uma Reddy,Donald M Lloyd-Jones,Philip Greenland,Sadiya S Khan,
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Rural America-Expanding the Lens of Health Disparities: Endorsing the Need for Health Equity Research. JAMA Cardiol. (IF 14.8) Pub Date : 2025-03-31 Sadiya S Khan,Clyde W Yancy
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Mining the Electronic Medical Record for Hypertension Treatment-Hope or Hype? JAMA Cardiol. (IF 14.8) Pub Date : 2025-03-31 Sadiya S Khan
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Cardiovascular Health Among Rural and Urban US Adults—Healthcare, Lifestyle, and Social Factors JAMA Cardiol. (IF 14.8) Pub Date : 2025-03-31 Michael Liu, Lucas X. Marinacci, Karen E. Joynt Maddox, Rishi K. Wadhera
ImportanceImproving cardiovascular health in rural areas is a national priority in the US. However, little is known about the current state of rural cardiovascular health and the underlying drivers of any rural-urban disparities.ObjectiveTo compare rates of cardiometabolic risk factors and cardiovascular diseases between rural and urban US adults and to evaluate the extent to which health care access
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Leveraging Preexisting Cardiovascular Data to Improve the Detection and Treatment of Hypertension JAMA Cardiol. (IF 14.8) Pub Date : 2025-03-31 Adam N. Berman, Michael K. Hidrue, Curtis Ginder, Linnea Shirkey, Japneet Kwatra, Anna C. O’Kelly, Sean P. Murphy, Jennifer M. Searl Como, Danielle Daly, Yee-Ping Sun, William T. Curry, Marcela G. del Carmen, Ron Blankstein, John A. Dodson, David A. Morrow, Benjamin M. Scirica, Niteesh K. Choudhry, James L. Januzzi, Jason H. Wasfy
ImportanceHypertension is often underrecognized, leading to preventable morbidity and mortality. Tailored data systems combined with care augmented by trained nonphysicians have the potential to improve cardiovascular care.ObjectiveTo determine whether previously collected cardiovascular imaging data could be harnessed to improve the detection and treatment of hypertension through a system-level intervention
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Mode of Death in Patients With Heart Failure With Mildly Reduced or Preserved Ejection Fraction JAMA Cardiol. (IF 14.8) Pub Date : 2025-03-30 Akshay S. Desai, Pardeep S. Jhund, Muthiah Vaduganathan, Brian L. Claggett, Jonathan W. Cunningham, Maria A. Pabon, Carolyn S. P. Lam, Michele Senni, Sanjiv Shah, Adriaan A. Voors, Faiez Zannad, Bertram Pitt, Flaviana Amarante, James Lay-Flurrie, Markus F. Scheerer, Andrea Lage, John J. V. McMurray, Scott D. Solomon
ImportanceThe mode of death in patients with heart failure with mildly reduced ejection fraction (HFmrEF) or heart failure with preserved ejection fraction (HFpEF) remains poorly understood and may vary by EF.ObjectiveTo evaluate the mode of death according to EF and the treatment effect of finerenone on cause-specific mortality in patients with HFmrEF/HFpEF.Design, Setting, and ParticipantsThis was
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Finerenone and Atrial Fibrillation in Heart Failure JAMA Cardiol. (IF 14.8) Pub Date : 2025-03-29 Shingo Matsumoto, Alasdair D. Henderson, Pardeep S. Jhund, Johann Bauersachs, Ovidiu Chioncel, Brian L. Claggett, Josep Comin-Colet, Akshay S. Desai, Gerasimos Filippatos, Carolyn S. P. Lam, Bertram Pitt, Markus Florian Scheerer, James Lay-Flurrie, Flaviana Amarante, Meike Brinker, Morten Schou, Michele Senni, Sanjiv J. Shah, Adriaan A. Voors, Faiez Zannad, Shelley Zieroth, Muthiah Vaduganathan, Scott
ImportanceHeart failure (HF) with mildly reduced or preserved ejection fraction and atrial fibrillation (AF) are closely intertwined.ObjectiveTo examine the efficacy and safety of the nonsteroidal mineralocorticoid receptor antagonist finerenone in patients with HF with mildly reduced or preserved ejection fraction according to the absence or presence of AF and the type of AF (paroxysmal vs persistent
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Aortic Valve Intervention for Asymptomatic Aortic Stenosis. JAMA Cardiol. (IF 14.8) Pub Date : 2025-03-26 Rick A Nishimura,Patrick T O'Gara,Robert O Bonow
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Asundexian or Apixaban in Patients With Atrial Fibrillation According to Prior Oral Anticoagulant Use JAMA Cardiol. (IF 14.8) Pub Date : 2025-03-26 John H. Alexander, Elizabeth J. Lydon, Jonathan P. Piccini, Thomas Viethen, Jonas Oldgren, Shaun G. Goodman, Jan Steffel, Andrea M. Russo, Isabelle C. van Gelder, Keith C. Ferdinand, Renato D. Lopes, Hardi Mundl, Bela Benczur, Juan José Gómez-Doblas, Michael Glikson, Assen Goudev, Erik L. Grove, Sigrun Halvorsen, Tuomas Kiviniemi, Anne-Céline Martin, Roopinder K. Sandhu, Dragos Vinereanu, Frank W.
ImportanceIn patients with atrial fibrillation (AF), oral anticoagulants (OACs) reduce the risk of stroke.ObjectiveTo investigate if patients with less prior OAC exposure respond differently to a new OAC than patients with more OAC exposure.Design, Setting, and ParticipantsIn this prespecified exploratory subgroup analysis of the Oral Factor 11a Inhibitor Asundexian as Novel Antithrombotic–Atrial Fibrillation
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Encouraging Pharmacist Referrals for Evidence-Based Statin Initiation JAMA Cardiol. (IF 14.8) Pub Date : 2025-03-26 Alexander C. Fanaroff, Qian Huang, Kayla Clark, Laurie A. Norton, Wendell E. Kellum, Dwight Eichelberger, John C. Wood, Zachary Bricker, Andrea G. Dooley Wood, Greta Kemmer, Jennifer I. Smith, Srinath Adusumalli, Mary E. Putt, Kevin G. Volpp
ImportanceDespite statins’ benefit in preventing major adverse cardiovascular events, most patients with an indication for statin therapy are not appropriately treated. Clinicians’ limited time and lack of systematic efforts to address preventive care likely contribute to gaps in statin prescribing.ObjectiveTo determine the effect on statin prescribing of 2 interventions to refer appropriate patients
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Peak Oxygen Uptake vs Ventilatory Efficiency. JAMA Cardiol. (IF 14.8) Pub Date : 2025-03-19 Jiawei Du,Jinghua Hou
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Peak Oxygen Uptake Vs Ventilatory Efficiency-In Reply. JAMA Cardiol. (IF 14.8) Pub Date : 2025-03-19 Matthew M Y Lee,Gregory D Lewis
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A Man in His 30s With Ponytail Coronary Artery Anomaly. JAMA Cardiol. (IF 14.8) Pub Date : 2025-03-19 Leizhi Ku,Xiaojing Ma
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Joint Associations of APOC3 and LDL-C–Lowering Variants With the Risk of Coronary Heart Disease JAMA Cardiol. (IF 14.8) Pub Date : 2025-03-19 Wenxiu Wang, Rui Li, Zimin Song, Ninghao Huang, Tao Huang, Xinwei Hua, Yi-Da Tang
ImportanceDespite substantial progress in low-density lipoprotein cholesterol (LDL-C)–lowering strategies, residual cardiovascular risk remains. Apolipoprotein C3 (APOC3) has emerged as a novel target for lowering triglycerides. Multiple clinical trials of small-interfering RNA therapeutics targeting APOC3 are currently underway.ObjectiveTo investigate whether genetically predicted lower APOC3 is associated
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Concomitant Mechanical Aspiration and Appendage Closure for Recalcitrant Left Atrial Appendage Thrombi JAMA Cardiol. (IF 14.8) Pub Date : 2025-03-19 Maryam Saleem, Abhishek Maan, Daniel R. Musikantow, Chi Zhang, Yury Malyshev, Marc A. Miller, Srinivas R. Dukkipati, Parasuram M. Krishnamoorthy, Martin Goldman, Prakash Krishnan, Vivek Y. Reddy
ImportanceIt is well appreciated that a small yet high-risk subset of patients with atrial fibrillation (AF) develops persistent left atrial appendage (LAA) thrombus despite optimal oral anticoagulation (OAC). In patients with either a heightened risk of bleeding precluding enhanced doses of OAC to dissolve the thrombus, or thromboembolism despite optimal OAC, there are limited nonsurgical options
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FFR-Guided Percutaneous Coronary Intervention vs Coronary Artery Bypass Grafting in Patients With Diabetes. JAMA Cardiol. (IF 14.8) Pub Date : 2025-03-12 Kuniaki Takahashi,Hisao Otsuki,Frederik M Zimmermann,Victoria Y Ding,Thomas Engstrøm,Hans Gustav Hørsted Thyregod,Branko Beleslin,Svetozar Putnik,Luke Tapp,Thomas Barker,Simon Redwood,Christopher Young,G Jan-Willem Bech,Gerard J F Hoohenkerk,Bernard De Bruyne,Nico H J Pijls,William F Fearon,
Importance Outcomes in patients with diabetes after fractional flow reserve (FFR)-guided percutaneous coronary intervention (PCI) using current-generation drug-eluting stents (DES) compared with coronary artery bypass grafting (CABG) are unknown. Objectives To investigate the relative treatment effect of PCI vs CABG according to diabetes status with respect to major adverse cardiac and cerebrovascular
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Food Insecurity and Incident Cardiovascular Disease Among Black and White US Individuals, 2000-2020 JAMA Cardiol. (IF 14.8) Pub Date : 2025-03-12 Jenny Jia, Mercedes R. Carnethon, Mandy Wong, Cora E. Lewis, Pamela J. Schreiner, Namratha R. Kandula
ImportanceFood insecurity is associated with prevalent cardiovascular disease (CVD), but studies have been limited to cross-sectional data.ObjectivesTo study whether food insecurity is associated with incident CVD and to determine whether this association varies by sex, education, or race.Design, Setting, and ParticipantsThis prospective cohort study was conducted among US adults without preexisting
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Exercise-Induced Dyspnea in an Older Woman With a History of Coronary Artery Disease JAMA Cardiol. (IF 14.8) Pub Date : 2025-03-12 Soundous M’Rabet, Jean-Christophe Eicher, Charles Guenancia
An older woman with a history of coronary artery disease presents with dyspnea upon exertion. A transthoracic echocardiogram reveals severe mitral regurgitation, and an electrocardiogram reveals sinus tachycardia with left bundle branch block. What would you do next?
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Novel Controlled Metabolic Accelerator for Obesity-Related HFpEF JAMA Cardiol. (IF 14.8) Pub Date : 2025-03-12 Ambarish Pandey, Gregory D. Lewis, Barry A. Borlaug, Sanjiv J. Shah, Andrew J. Sauer, Sheldon Litwin, Kavita Sharma, Diane K. Jorkasky, Elizabeth A. Tarka, Shaharyar M. Khan, Dalane W. Kitzman
ImportanceExcess body fat plays a pivotal role in the pathogenesis of heart failure with preserved ejection fraction (HFpEF). HU6 is a novel, controlled metabolic accelerator that enhances mitochondrial uncoupling resulting in increased metabolism and fat-specific weight loss.ObjectiveTo assess efficacy and safety of HU6 in reducing body weight, improving peak volume of oxygen consumption (VO2) and
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Filling the Evidence Gaps Toward a Coronary Artery Calcium-Guided Primary Prevention Strategy. JAMA Cardiol. (IF 14.8) Pub Date : 2025-03-05 Michael J Blaha
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Valsartan and Cardiac Remodeling in Early-Stage Hypertrophic Cardiomyopathy: The VANISH Randomized Clinical Trial Cardiac Magnetic Resonance Substudy. JAMA Cardiol. (IF 14.8) Pub Date : 2025-03-05 John W Ostrominski,Brian L Claggett,Michael Jerosch-Herold,Anna Axelsson Raja,Sharlene M Day,Mark W Russell,Kenneth Zahka,Alexandre C Pereira,Steven D Colan,Anne M Murphy,Charles Canter,Richard G Bach,Matthew T Wheeler,Joseph W Rossano,Anjali T Owens,Luisa Mestroni,Matthew R G Taylor,Amit R Patel,Ivan Wilmot,Jonathan H Soslow,Jason R Becker,Neal K Lakdawala,Henning Bundgaard,Jose D Vargas,Carolyn Y
Importance Valsartan has been shown to attenuate phenotypic progression among individuals with early-stage sarcomeric hypertrophic cardiomyopathy (HCM). Myocardial tissue characterization by cardiac magnetic resonance (CMR) imaging may enhance mechanistic insights, but whether valsartan influences these parameters remains uncertain. Objective To evaluate the treatment effects of valsartan on myocardial
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Finerenone for Heart Failure and Risk Estimated by the PREDICT-HFpEF Model JAMA Cardiol. (IF 14.8) Pub Date : 2025-03-05 Kirsty McDowell, Kieran F. Docherty, Ross T. Campbell, Alasdair D. Henderson, Pardeep S. Jhund, Brian L. Claggett, Akshay S. Desai, James Lay-Flurrie, Lucas Hofmeister, Andrea Scalise, Carolyn S. P. Lam, Mark C. Petrie, Morten Schou, Michele Senni, Sanjiv J. Shah, Jacob A. Udell, Faiez Zannad, Bertram Pitt, Muthiah Vaduganathan, Scott D. Solomon, John J. V. McMurray
ImportancePatients with heart failure (HF) and mildly reduced ejection fraction (HFmrEF) or preserved ejection fraction (HFpEF) have a spectrum of risk, and the effect of therapies may vary by risk.ObjectivesTo validate the Prognostic Models for Mortality and Morbidity in HFpEF (PREDICT-HFpEF) in the phase 3 randomized clinical trial Finerenone Trial to Investigate Efficacy and Safety Superior to Placebo
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Coronary Artery Calcium Testing—Too Early, Too Late, Too Often JAMA Cardiol. (IF 14.8) Pub Date : 2025-03-05 Alexander R. Zheutlin, Anuj K. Chokshi, John T. Wilkins, Neil J. Stone
ImportanceTraditional risk factors, enhancing factors, and risk scores help clinicians assess atherosclerotic cardiovascular disease (ASCVD) risk for primary prevention. The latest cholesterol guidelines suggest measuring coronary artery calcium (CAC) score by computed tomography (CT) in those at intermediate risk when there is uncertainty about statin initiation for primary prevention. CAC testing
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Importance of Age and Sex in Carotid Artery Plaque Detection and Cardiovascular Disease Risk JAMA Cardiol. (IF 14.8) Pub Date : 2025-03-05 Matthew C. Tattersall, Spencer L. Hansen, Robyn L. McClelland, Claudia E. Korcarz, Kristin M. Hansen, Wendy S. Post, Michael D. Shapiro, James H. Stein
ImportanceCarotid artery plaque (CAP) is commonly encountered in clinical practice. Presence of CAP predicts future atherosclerotic cardiovascular disease (ASCVD) events; however, CAP prevalence increases with age, and it is unknown how age and sex affect the association of CAP presence and ASCVD risk.ObjectivesTo describe CAP prevalence by age, sex, race, and ethnicity in a multiethnic population
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Simultaneous or Rapid Initiation of Combination Therapy for Heart Failure With Preserved Ejection Fraction JAMA Cardiol. (IF 14.8) Pub Date : 2025-03-05 Stephen J. Greene, Javed Butler, Gregg C. Fonarow
This Viewpoint recommends simultaneous or rapid sequence initiation of combination therapy with 3 specific classes of medication for heart failure with mildly reduced ejection fraction or preserved ejection fraction.
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Finerenone and Outpatient Worsening Heart Failure With Mildly Reduced or Preserved Ejection Fraction JAMA Cardiol. (IF 14.8) Pub Date : 2025-02-26 Jonathan W. Cunningham, Safia Chatur, Brian L. Claggett, Muthiah Vaduganathan, Akshay S. Desai, Pardeep S. Jhund, Guillermo Llamas Esperón, Carolyn S. P. Lam, Naoki Sato, Michele Senni, Sanjiv Shah, Adriaan Voors, Faiez Zannad, Bertram Pitt, Shelley Zieroth, Meike Brinker, Katja Rohwedder, So-Young Kim, James Lay-Flurrie, Prabhakar Viswanathan, John J. V. McMurray, Scott D. Solomon
ImportanceWorsening heart failure (HF) is commonly managed in the outpatient setting with adjustments in oral diuretic therapy. The effect of the nonsteroidal mineralocorticoid receptor antagonist finerenone on outpatient worsening HF events in patients with mildly reduced or preserved ejection fraction is unknown.ObjectiveTo evaluate the effect of finerenone on outpatient worsening HF events requiring
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New Right Atrial Image After Coronary Revascularization Surgery JAMA Cardiol. (IF 14.8) Pub Date : 2025-02-26 Clara Nuevo-Gallardo, María Reyes González-Fernández, María Yuste-Domínguez
This case report describes a saphenous vein graft simulating an intracardiac structure on echocardiography of a patient after coronary revascularization surgery.
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Safety, Feasibility, and Diagnostic Yield of Invasive Coronary Function Testing: Netherlands Registry of Invasive Coronary Vasomotor Function Testing. JAMA Cardiol. (IF 14.8) Pub Date : 2025-04-01 Caïa Crooijmans,Tijn P J Jansen,Joan G Meeder,Janneke Woudstra,Martijn Meuwissen,Annemiek M J De Vos,Valeria Paradies,Els G M Olde Bijvank,Patty Winkler,Nicola S Vos,Karin Arkenbout,Pier Woudstra,Martin G Stoel,Tim P Van de Hoef,Stijn C H Van den Oord,Jos W M G Widdershoven,Wouter Remkes,Aysun Cetinyurek-Yavuz,Hester M Den Ruijter,N Charlotte Onland-Moret,Eric Boersma,Marcel A M Beijk,Yolande Appelman
Importance Patients with angina and no obstructive coronary artery disease frequently have coronary vasomotor dysfunction as underlying pathophysiological mechanism, comprising epicardial spasm, microvascular spasm, and/or microcirculatory dysfunction. These endotypes can be diagnosed by invasive coronary function testing which has previously shown to be safe in tertiary and expert centers. Objective
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Donning the Hijab-A Cardiology Fellow's Journey With Advocacy and Inclusion. JAMA Cardiol. (IF 14.8) Pub Date : 2025-04-01 Najah Ali Khan
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Sex-Specific Association of Myocardial Fibrosis With Mortality in Patients With Aortic Stenosis JAMA Cardiol. (IF 14.8) Pub Date : 2025-02-19 Soongu Kwak, Anvesha Singh, Russell J. Everett, Thomas A. Treibel, Jaehyun Lim, Sungho Won, Michelle C. Williams, Krithika Loganathan, Rong Bing, Neil Craig, Trisha Singh, Shruti Joshi, Heesun Lee, Whal Lee, Yong-Jin Kim, Calvin W. L. Chin, Miho Fukui, Tarique Al Musa, Marzia Rigolli, Lionel Tastet, Laura E. Dobson, Stephanie Wiesemann, Vanessa M. Ferreira, Gabriella Captur, Sahmin Lee, Jeanette Schulz-Menger
ImportanceMyocardial fibrosis in aortic stenosis (AS) may exhibit sex differences. However, its prognostic significance in women with AS remains unclear.ObjectiveTo investigate sex differences in myocardial fibrosis assessed by cardiovascular magnetic resonance (CMR) and evaluate its prognostic value in women and men with AS.Design, Setting, and ParticipantsPatients with severe AS who underwent CMR
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Intensive Blood Pressure Control in Older Adults-Reply. JAMA Cardiol. (IF 14.8) Pub Date : 2025-04-01 Xiaofan Guo,Guozhe Sun,Yingxian Sun
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Intensive Blood Pressure Control in Older Adults. JAMA Cardiol. (IF 14.8) Pub Date : 2025-04-01 Yuxian Huang,Xiangmin Tan
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Arrhythmic Risk Stratification of Carriers of Filamin C Truncating Variants. JAMA Cardiol. (IF 14.8) Pub Date : 2025-04-01 ,Marta Gigli,Davide Stolfo,Giulia Barbati,Sharon Graw,Suet Nee Chen,Marco Merlo,Kristen Medo,Caterina Gregorio,Matteo Dal Ferro,Alessia Paldino,Maria Perotto,J Peter van Tintelen,Anneline S J M Te Riele,Annette F Baas,Arthur M Wilde,Ahmad S Amin,Arjan C Houweling,Perry Elliott,Douglas Cannie,Michelle Michels,Stephan A C Schoonvelde,Sanjay Prasad,Paz Upasana Tayal,Momina Yazdani,Deborah Morris-Rosendahl
Importance Filamin C truncating variants (FLNCtv) are a rare cause of cardiomyopathy with heterogeneous phenotypic presentations. Despite a high incidence of life-threatening ventricular arrhythmias and sudden cardiac death (SCD), reliable risk predictors to stratify carriers of FLNCtv are lacking. Objective To determine factors predictive of SCD/major ventricular arrhythmias (MVA) in carriers of FLNCtv
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Patient Enrollment for Cardiovascular Clinical Trials in the United States. JAMA Cardiol. (IF 14.8) Pub Date : 2025-03-01 Muhammad Shahzeb Khan,Adeena Jamil,Muteia Shakoor,Stephen J Greene,Gregg C Fonarow,Deepak L Bhatt,J Michael DiMaio,Michael J Mack,Javed Butler
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Olpasiran, Oxidized Phospholipids, and Systemic Inflammatory Biomarkers: Results From the OCEAN(a)-DOSE Trial. JAMA Cardiol. (IF 14.8) Pub Date : 2025-02-12 Robert S Rosenson,J Antonio G López,Daniel Gaudet,Seth J Baum,Elmer Stout,Norman E Lepor,Jeong-Gun Park,Sabina A Murphy,Beat Knusel,Jingying Wang,Tomaz Wilmanski,Huei Wang,You Wu,Helina Kassahun,Marc S Sabatine,Michelle L O'Donoghue,
Importance Lipoprotein(a) (Lp[a]) is thought to be the major carrier of oxidized phospholipids (OxPL). OxPL are believed to be a potent driver of inflammation and atherosclerosis. Olpasiran, a small interfering RNA, blocks Lp(a) production by inducing degradation of apolipoprotein(a) messenger RNA. Olpasiran's effects on OxPL and systemic markers of inflammation are not well described. Objective To
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Aortic Valve Replacement for Asymptomatic Severe Aortic Stenosis—The Time Has Come JAMA Cardiol. (IF 14.8) Pub Date : 2025-02-12 Brian R. Lindman, Eugene Braunwald, Patricia A. Pellikka
This Viewpoint advocates for prompt aortic valve replacement (rather than clinical surveillance) as the default strategy for patients with asymptomatic severe aortic stenosis.
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The Cardiovascular Disease Divide-A Tale of 2 High-Income Nations. JAMA Cardiol. (IF 14.8) Pub Date : 2025-04-01 Sadiya S Khan
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Dietary Sodium- and Potassium-Enriched Salt Substitutes-The Tipping Point? JAMA Cardiol. (IF 14.8) Pub Date : 2025-04-01 Daniel W Jones,Brent M Egan,Daniel Thomas Lackland
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Salt Substitution and Recurrent Stroke and Death JAMA Cardiol. (IF 14.8) Pub Date : 2025-02-05 Xiong Ding, Xinyi Zhang, Liping Huang, Shangzhi Xiong, Zhifang Li, Yi Zhao, Bo Zhou, Xuejun Yin, Bingqing Xu, Yanfeng Wu, Bruce Neal, Maoyi Tian, Lijing L. Yan
ImportanceThe direct effect of consumption of salt substitutes on recurrent stroke and mortality among patients with stroke remains unclear.ObjectiveTo evaluate the effects of salt substitutes vs regular salt on the incidence of recurrent stroke and mortality among patients with stroke.Design, Setting, and ParticipantsThe Salt Substitute and Stroke Study (SSaSS), an open-label, cluster randomized clinical
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Cardiovascular Hospitalizations Among Older Adults in the US and Denmark JAMA Cardiol. (IF 14.8) Pub Date : 2025-02-05 Frederikke Held Berg, Mats C. Højbjerg Lassen, Muthiah Vaduganathan, Gregg C. Fonarow, Robert W. Yeh, ZhaoNian Zheng, Gunnar H. Gislason, Tor Biering-Sørensen, Rishi K. Wadhera
ImportanceCardiovascular disease is the leading cause of death in the US. However, it remains unclear how the burden of cardiovascular events in the US compares with that of other high-income countries with distinct health care systems like Denmark, both overall and by income.ObjectiveTo compare cardiovascular hospitalization rates (acute myocardial infarction [MI], heart failure [HF], ischemic stroke)
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Recognition of the Large Ambulatory C2D Stage of Advanced Heart Failure—A Call to Action JAMA Cardiol. (IF 14.8) Pub Date : 2025-02-05 Shannon M. Dunlay, Sean P. Pinney, Anuradha Lala, Garrick C. Stewart, Colleen McIlvennan, Renee P. Wong, Alanna A. Morris, Francis D. Pagani, Larry A. Allen, Khadijah Breathett, Rebecca Cogswell, Monica M. Colvin, Jennifer A. Cowger, Stavros G. Drakos, Laura P. Gelfman, Manreet K. Kanwar, Michael S. Kiernan, Michelle M. Kittleson, Eldrin F. Lewis, Nader Moazami, Modele O. Ogunniyi, Ambarish Pandey
ImportanceThe advanced ambulatory heart failure (HF) population comprises patients who have progressed beyond the pillars of recommended stage C HF therapies but can still find meaningful life-years ahead. Although these patients are commonly encountered in practice, national databases selectively capture the small groups accepted for heart transplant listing or left ventricular assist devices. The
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Sodium Reduction Legislation and Urinary Sodium and Blood Pressure in South Africa JAMA Cardiol. (IF 14.8) Pub Date : 2025-02-05 Thomas Gaziano, David Kapaon, Jacques D. du Toit, Nigel J. Crowther, Alisha N. Wade, June Fabian, Carlos Riumallo-Herl, F. Carla Roberts-Toler, Xavier Gómez-Olivé, Stephen Tollman
ImportanceReductions in dietary salt are associated with blood pressure reductions; however, national governments that have passed laws to reduce sodium intake have not measured these laws’ impact.ObjectiveTo determine if South African regulations restricting sodium content in processed foods were associated with reductions in sodium consumption and blood pressure.Design, Setting, and ParticipantsThe
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Blood Pressure Control-Many Paths, 1 Goal. JAMA Cardiol. (IF 14.8) Pub Date : 2025-04-01 Erica S Spatz,Jeremy I Schwartz,Thomas R Frieden
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Treatment Strategies to Control Blood Pressure in People With Hypertension in Tanzania and Lesotho JAMA Cardiol. (IF 14.8) Pub Date : 2025-01-29 Herry Mapesi, Martin Rohacek, Fiona Vanobberghen, Ravi Gupta, Herieth Ismael Wilson, Blaise Lukau, Alain Amstutz, Aza Lyimo, Josephine Muhairwe, Elizabeth Senkoro, Theonestina Byakuzana, Jacqueline Nkouabi, Geofrey Mbunda, Jamali Siru, Ayesha Tarr, Elsie Ramapepe, Madavida Mphunyane, Johanna Oehri, Valeriya Nemtsova, Xiaohan Yan, Moniek Bresser, Tracy Renée Glass, Daniel Henry Paris, Günther Fink,
ImportanceHypertension is the primary cardiovascular risk factor in Africa. Recently revised World Health Organization guidelines recommend starting antihypertensive dual therapy; clinical efficacy and tolerability of low-dose triple combination remain unclear.ObjectivesTo compare the effect of 3 treatment strategies on blood pressure control among persons with untreated hypertension in Africa.Design
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Default Bulk Ordering and Text Messaging to Enhance Outreach for Lipid Screening JAMA Cardiol. (IF 14.8) Pub Date : 2025-01-29 Catherine Pollak, Andrew Parambath, Samantha Coratti, Laurie Norton, Anthony Girard, Catherine Reitz, Christopher K. Snider, Lin Xu, Zakiya Walker, Aileen John, Mary E. Putt, Kevin G. Volpp, Shivan J. Mehta
ImportanceA comprehensive lipid panel is recommended by guidelines to evaluate atherosclerotic cardiovascular disease risk, but uptake is low.ObjectiveTo evaluate whether direct outreach including bulk orders with and without text messaging increases lipid screening rates.Design, Setting, and ParticipantsPragmatic randomized clinical trial conducted from June 6, 2023, to September 6, 2023, at 2 primary
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Yellowish Nodules on a Man Consuming a Carnivore Diet. JAMA Cardiol. (IF 14.8) Pub Date : 2025-03-01 Konstantinos Marmagkiolis,Jaime Caballero,Cezar Iliescu
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Supine Blood Pressure and Risk of Cardiovascular Disease and Mortality JAMA Cardiol. (IF 14.8) Pub Date : 2025-01-22 Duc M. Giao, Hannah Col, Fredrick Larbi Kwapong, Ruth-Alma Turkson-Ocran, Long H. Ngo, Jennifer L. Cluett, Lynne Wagenknecht, B. Gwen Windham, Elizabeth Selvin, Pamela L. Lutsey, Stephen P. Juraschek
ImportanceNocturnal hypertension while asleep is associated with substantial increases in risk of cardiovascular disease (CVD) and death. Whether hypertension while supine is a risk factor associated with CVD independent of seated hypertension remains unknown.ObjectiveTo investigate the association between supine hypertension and CVD outcomes and by hypertension treatment status.Design, Setting, and
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Clinical Phenotype and Prognosis of Asymptomatic Patients With Transthyretin Cardiac Amyloid Infiltration JAMA Cardiol. (IF 14.8) Pub Date : 2025-01-22 Aldostefano Porcari, Yousuf Razvi, Francesco Cappelli, Christian Nitsche, Matteo Serenelli, Simone Longhi, Giulio Sinigiani, Alberto Cipriani, Alberto Aimo, Daniela Tomasoni, Mattia Zampieri, Anna Cantone, Valentina Allegro, Giuseppe Vergaro, Ahmad Masri, Marcus Urey, Adam Ioannou, Aviva Petrie, Navid Noory, Finn Gustafsson, Michael Poledniczek, Michele Emdin, Marco Metra, Gianfranco Sinagra, Ana Martinez-Naharro
ImportancePatients with transthyretin (ATTR) cardiac amyloid infiltration are increasingly diagnosed at earlier disease stages with no heart failure (HF) symptoms and a wide range of cardiac amyloid infiltration.ObjectiveTo characterize the clinical phenotype and natural history of asymptomatic patients with ATTR cardiac amyloid infiltration.Design, Setting, and ParticipantsThis cohort study analyzed
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Artificial Intelligence–Guided Lung Ultrasound by Nonexperts JAMA Cardiol. (IF 14.8) Pub Date : 2025-01-15 Cristiana Baloescu, John Bailitz, Baljash Cheema, Ravi Agarwala, Madeline Jankowski, Onyinyechi Eke, Rachel Liu, Jason Nomura, Lori Stolz, Luna Gargani, Eren Alkan, Tyler Wellman, Nripesh Parajuli, Andrew Marra, Yngvil Thomas, Daven Patel, Evelyn Schraft, James O’Brien, Christopher L. Moore, Michael Gottlieb
ImportanceLung ultrasound (LUS) aids in the diagnosis of patients with dyspnea, including those with cardiogenic pulmonary edema, but requires technical proficiency for image acquisition. Previous research has demonstrated the effectiveness of artificial intelligence (AI) in guiding novice users to acquire high-quality cardiac ultrasound images, suggesting its potential for broader use in LUS.ObjectiveTo
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Genetic Predisposition to Low-Density Lipoprotein Cholesterol and Incident Type 2 Diabetes JAMA Cardiol. (IF 14.8) Pub Date : 2025-01-15 Akshaya Ravi, Satoshi Koyama, So Mi Jemma Cho, Sara Haidermota, Whitney Hornsby, Patrick T. Ellinor, Pradeep Natarajan
ImportanceTreatment to lower high levels of low-density lipoprotein cholesterol (LDL-C) reduces incident coronary artery disease (CAD) risk but modestly increases the risk for incident type 2 diabetes (T2D). The extent to which genetic factors across the cholesterol spectrum are associated with incident T2D is not well understood.ObjectiveTo investigate the association of genetic predisposition to
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Genius and the CVD Polypill-A Step Toward Achieving Health Equity? JAMA Cardiol. (IF 14.8) Pub Date : 2025-03-01 Clyde W Yancy,Gregg C Fonarow