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Automated Urinary Chemokine Assays for Non-Invasive Detection of Kidney Transplant Rejection: A Prospective Cohort Study Am. J. Kidney Dis. (IF 13.2) Pub Date : 2023-09-29 Elisabet Van Loon, Claire Tinel, Henriette de Loor, Xavier Bossuyt, Jasper Callemeyn, Maarten Coemans, Katrien De Vusser, Virginia Sauvaget, Juliette Olivre, Priyanka Koshy, Dirk Kuypers, Ben Sprangers, Amaryllis H. Van Craenenbroeck, Thibaut Vaulet, Dany Anglicheau, Maarten Naesens
Rationale & Objective Prior studies have demonstrated the diagnostic potential of urinary chemokines CXCL9 and CXCL10 for kidney transplant rejection. However, their benefit in addition to clinical information has not been demonstrated. We evaluated the diagnostic performance for detecting acute rejection of urinary CXCL9 and CXCL10 when integrated with clinical information. Study Design Single-center
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Disparities in Gender Representation Among First and Senior Authors in High-Impact Nephrology RCTs, 2000-2022 Am. J. Kidney Dis. (IF 13.2) Pub Date : 2023-09-29 Subhash Chander, Roopa Kumari, F.N.U. Sadarat, Om Parkash, Deepak Kumar, Sindhu Luhana
Abstract not available
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Ofatumumab in Rituximab-Resistant and Rituximab-Intolerant Patients With Primary Membranous Nephropathy Am. J. Kidney Dis. (IF 13.2) Pub Date : 2023-09-29 Manuel Alfredo Podestà, Matias Trillini, Valentina Portalupi, Alessia Gennarini, Federica Tomatis, Alessandro Villa, Annalisa Perna, Nadia Rubis, Giuseppe Remuzzi, Piero Ruggenenti
Rationale & Objective Rituximab is the first-choice therapy for patients with primary membranous nephropathy (MN) and nephrotic syndrome (NS). However, approximately 30% of patients are treatment-resistant or become treatment-intolerant with hypersensitivity reactions upon repeated drug exposures. We aimed to assess whether ofatumumab, a fully human second-generation anti-CD20 antibody, could be a
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Kidney Function, Albuminuria and Risk of Incident Atrial Fibrillation: A Systematic Review and Meta-Analysis Am. J. Kidney Dis. (IF 13.2) Pub Date : 2023-09-29 Jeffrey T. Ha, S. Ben Freedman, Dearbhla M. Kelly, Brendon L. Neuen, Vlado Perkovic, Min Jun, Sunil V. Badve
Rationale & Objective Atrial fibrillation (AF) and chronic kidney disease (CKD) often coexist. However, it is not known whether CKD is an independent risk factor for incident AF. Therefore, we evaluated the association between markers of CKD, estimated glomerular filtration rate (eGFR) and albuminuria, and incident AF. Study Design Systematic review and meta-analysis of cohort studies and randomized
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The Treatment of Primary IgA Nephropathy: Change, Change, Change Am. J. Kidney Dis. (IF 13.2) Pub Date : 2023-09-23 Dawn J. Caster, Richard A. Lafayette
IgA nephropathy (IgAN) is the most common glomerular disease in the world. However, the approach to treatment remains controversial. There has been an explosion of clinical trials over the past decade both further examining corticosteroid use and ushering in additional treatment considerations, including two newly approved therapies for IgAN. Sodium glucose cotransporter-2 inhibitors are proving to
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Kidney Transplantation in Patients With AA Amyloidosis: Outcomes in a French Multicenter Cohort Am. J. Kidney Dis. (IF 13.2) Pub Date : 2023-09-22 Chloë Schwarz, Sophie Georgin-Lavialle, Yannis Lombardi, Olivier Marion, Frédéric Jambon, Christophe Legendre, David Marx, Charlène Levi, Fatouma Toure, Moglie Le Quintrec, Mickael Bobot, Marie Matignon, Amaury Dujardin, Mehdi Maanaoui, Sébastien Cuozzo, Arwa Jalal-Eddine, Kévin Louis, Inna Mohamadou, François Brazier, Tristan De Nattes, Yosu Luque
Rationale & Objective Outcomes of kidney transplantation for patients with renal AA amyloidosis are uncertain, with reports of poor survival and high rates of disease recurrence. However, data are inconclusive and mostly based on studies from the early 2000s and earlier. Study Design Retrospective multicenter cohort study. Setting & Participants We searched the French national transplant database to
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Apathy Symptoms, Physical and Cognitive Function, Health-Related Quality of Life, and Mortality in Older Patients With CKD: A Longitudinal Observational Study Am. J. Kidney Dis. (IF 13.2) Pub Date : 2023-09-22 Carlijn GN. Voorend, Marjolijn van Buren, Noeleen C. Berkhout-Byrne, Angèle PM. Kerckhoffs, Mathijs van Oevelen, Jacobijn Gussekloo, Edo Richard, Willem Jan W Bos, Simon P. Mooijaart
Rationale & Objective Apathy reflects diminished motivation, goal-directed behavior, and emotions, as well as less engagement in social interactions. Apathy overlaps with depression and is associated with cognitive decline. In the older individuals with chronic kidney disease (CKD), both depression and cognitive impairments are common, but apathy symptoms have been underreported. We investigated the
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OpenAI’s ChatGPT and Its Potential Impact on Narrative and Scientific Writing in Nephrology Am. J. Kidney Dis. (IF 13.2) Pub Date : 2023-09-22 John T. Daugirdas
Abstract not available
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Brain Natriuretic Peptide Monitoring in CKD: Ready for Prime Time? Am. J. Kidney Dis. (IF 13.2) Pub Date : 2023-09-21 Alexander J. Kula, Nisha Bansal
Abstract not available
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Frailty and Cardiovascular Outcomes in Adults With CKD: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study Am. J. Kidney Dis. (IF 13.2) Pub Date : 2023-09-21 Mary Hannan, Jinsong Chen, Jesse Hsu, Xiaoming Zhang, Milda R. Saunders, Julia Brown, Mara McAdams-DeMarco, Madhumita Jena Mohanty, Rahul Vyas, Zahraa Hajjiri, Eunice Carmona-Powell, Natalie Meza, Anna C. Porter, Ana C. Ricardo, James P. Lash
Rationale & Objective Frailty is common in individuals with chronic kidney disease (CKD) and increases the risk of adverse outcomes in adults with kidney failure requiring dialysis. However, this relationship has not been thoroughly evaluated among those with non-dialysis dependent CKD. Study Design Prospective cohort study. Setting & Participants: 2,539 adults in the Chronic Renal Insufficiency Cohort
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The Association of Class I and II Human Leukocyte Antigen Serotypes With End-Stage Kidney Disease Due to Membranoproliferative Glomerulonephritis and Dense Deposit Disease Am. J. Kidney Dis. (IF 13.2) Pub Date : 2023-09-20 Halimat Afolabi, Bing M. Zhang, Michelle O’Shaughnessy, Glenn M. Chertow, Richard Lafayette, Vivek Charu
Rationale & Objective Membranoproliferative glomerulonephritis (MPGN), encompassing several distinct diseases, is a rare but significant cause of kidney failure in the US. Potential etiologies of MPGN are unclear, but prior studies have suggested dysregulation of the alternative complement pathway, and recently, autoimmunity as potential mechanisms driving MPGN pathogenesis. In this study, we examined
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Processes of Care After Hospital Discharge for Survivors of Acute Kidney Injury: A Population-Based Cohort Study Am. J. Kidney Dis. (IF 13.2) Pub Date : 2023-09-19 Sandeep Brar, Feng Ye, Matthew T. James, Tyrone G. Harrison, Neesh Pannu
Rationale & Objective Survivors of acute kidney injury (AKI) are at high risk of adverse outcomes. Monitoring of kidney function, screening for proteinuria, use of statins and renin-angiotensin-aldosterone system inhibitors (RAASi), and nephrology follow-up among survivors have not been fully characterized. We sought to examine these processes of care after discharge in survivors of hospitalized AKI
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A Case of Autosomal Dominant Polycystic Kidney Disease With Resolution of Massive Pericardial Effusion After Renal Transcatheter Artery Embolization Am. J. Kidney Dis. (IF 13.2) Pub Date : 2023-09-20 Kumi Nitta, Yuki Oba, Daisuke Ikuma, Hiroki Mizuno, Akinari Sekine, Eiko Hasegawa, Masayuki Yamanouchi, Tatsuya Suwabe, Masahide Tokue, Masanori Shiba, Naoki Sawa, Yoshifumi Ubara
A 68-year-old woman with autosomal dominant polycystic kidney disease (ADPKD) on hemodialysis was admitted for progressive dyspnea over 6 months. On chest X-ray, her cardiothoracic ratio (CTR) had increased from 52.2% 6 months prior, to 71%, and echocardiography revealed diffuse pericardial effusion and right ventricular diastolic insufficiency. A resultant pericardial tamponade was thought to be the
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Etiologic and Diagnostic Implications of Morbidity and Mortality Associations When Cystatin C–Based Estimated GFR Is Lower Than Creatinine-Based Estimated GFR Am. J. Kidney Dis. (IF 13.2) Pub Date : 2023-09-20 Anders O. Grubb, Martin Magnusson, Anders Christensson
Abstract not available
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Advance Care Planning and Palliative Care Consultation in Kidney Transplantation Am. J. Kidney Dis. (IF 13.2) Pub Date : 2023-09-20 Marlena C. Fisher, Xiaomeng Chen, Deidra C. Crews, Lyndsay DeGroot, Nwamaka D. Eneanya, Nidhi Ghildayal, Marshall Gold, Yi Liu, Justin J. Sanders, Jennifer S. Scherer, Dorry L. Segev, Mara A. McAdams-DeMarco
Rationale & Objective Due to the high risk of waitlist mortality and post-transplant complications, kidney transplant (KT) patients may benefit from advance care planning (ACP) and palliative care consultation (PCC). We quantified the prevalence and racial disparities in ACP and PCC among KT candidates and recipients. Study Design Prospective cohort study Setting & Participants 2,575 adult KT candidates
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Cryoglobulinemic Vasculitis in Disguise: Cryofibrinogenemia as Variant of Monoclonal Gammopathy of Renal Significance Am. J. Kidney Dis. (IF 13.2) Pub Date : 2023-09-19 Christina M. Gant, Carin A. Koelman, Tri Q. Nguyen TQ, Alferso C. Abrahams, Jack F.M. Wetzels, Caroline Duineveld, Margot Jak, Monique C. Minnema, Saskia K. Klein, Joannes F.M. Jacobs, Renate J. Bosma
Monoclonocal gammopathy with cryoactivity (i.e. cryoglobulins) that causes glomerulonephritis is considered within the spectrum of monoclonal gammopathy of renal significance (MGRS). Cryofibrinogenemia (cryoactivity of coagulation factors) is very rarely associated with glomerulonephritis. We present a 39 year old woman with a relapsing nephrotic syndrome. Laboratory investigation detected cryofibrinogen
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Experiences of Indigenous Patients Receiving Dialysis: Systematic Review of Qualitative Studies Am. J. Kidney Dis. (IF 13.2) Pub Date : 2023-09-18 Marianne Kerr, Allison Jaure, Jacqueline H. Stephens, Siah Kim, Richard Cutler, Brydee Cashmore, Michelle Dickson, Nicole Evangelidis, Jaquelyne T. Hughes, Ieyesha Roberts, Nicole Scholes-Robertson, Victoria Sinka, GradDip, Jonathan C. Craig
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A Young Man With Chronic Refractory Hypokalemia: A Quiz Am. J. Kidney Dis. (IF 13.2) Pub Date : 2023-09-20 Mohamad Hanouneh, Carmen Elena Cervantes
Abstract not available
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Performance of GFR Estimating Equations in Young Adults Am. J. Kidney Dis. (IF 13.2) Pub Date : 2023-09-17 Lesley A. Inker, Hocine Tighiouart, Ogechi M. Adingwupu, Derek K. Ng, Michelle M. Estrella, David Maahs, Wei Yang, Marc Froissart, Michael Mauer, Roberto Kalil, Vicente Torres, Martin de Borst, Goran Klintmalm, Emilio D. Poggio, Jesse C. Seegmiller, Peter Rossing, Susan L. Furth, Bradley A. Warady, George J. Schwartz, Ruben Velez, Andrew Levey
Abstract not available
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Urinary Biomarkers and Kidney Injury in VA NEPHRON-D: Phenotyping Acute Kidney Injury in Clinical Trials Am. J. Kidney Dis. (IF 13.2) Pub Date : 2023-09-17 Elizabeth A. Kiernan, David Hu, Heather Thiessen Philbrook, Joachim H. Ix, Joseph V. Bonventre, Steven G. Coca, Dennis G. Moledina, Linda F. Fried, Michael G. Shlipak, Chirag R. Parikh
Rationale & Objective Urinary biomarkers of injury, inflammation and repair may help phenotype observed AKI in clinical trials. We evaluated differences in biomarkers between those randomized to monotherapy or to combination RAAS blockade in VA NEPHRON-D, acknowledging an increased proportion of observed AKI in the combination arm. Study Design Longitudinal analysis. Setting & Participants: A sub-study
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Kidney Transplant Clinicians’ Perceptions of Palliative Care for Patients With Failing Allografts in the US: A Mixed Methods Study Am. J. Kidney Dis. (IF 13.2) Pub Date : 2023-09-17 Naoka Murakami, Amanda J. Reich, Katherine He, Samantha L. Gelfand, Richard E. Leiter, Kate Sciacca, Joel T. Adler, Emily Lu, Song C. Ong, Beatrice P. Concepcion, Neeraj Singh, Haris Murad, Prince Anand, Sarah J. Ramer, Darshana Dadhania, Krista L. Lentine, Joshua R. Lakin, Tarek Alhamad
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Factors Associated With Non-Vaccination for Influenza Among Patients With CKD: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study Am. J. Kidney Dis. (IF 13.2) Pub Date : 2023-09-17 Junichi Ishigami, Bernard G. Jaar, Jeanne B. Charleston, James P. Lash, Julia Brown, Jing Chen, Katherine T. Mills, Jonathan Taliercio, Sheru Kansal, Deidra C. Crews, Kristin A. Riekert, David W. Dowdy, Lawrence J. Appel, Kunihiro Matsushita
Rationale & Objective Vaccination for influenza is strongly recommended for people with chronic kidney disease (CKD) due to their immunocompromised state. Identifying risk factors for not receiving an influenza vaccine (“non-vaccination”) could inform strategies for improving vaccine uptake in this high-risk population. Study Design Longitudinal observational study. Setting & Participants: 3,692 Chronic
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The Status of Kidney Transplant Fellowship in the United States: A Survey of Program Directors Am. J. Kidney Dis. (IF 13.2) Pub Date : 2023-09-17 Shilpi Shah, Vishnu S. Potluri, Roy D. Bloom, Mary Ann Lim
Abstract not available
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Vitamin D in CKD: An Unfinished Story Am. J. Kidney Dis. (IF 13.2) Pub Date : 2023-09-16 Simon Hsu, Marc G. Vervloet, Ian H. de Boer
Abstract not available
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Genetic Markers Among the Israeli Druze Minority Population With End-Stage Kidney Disease Am. J. Kidney Dis. (IF 13.2) Pub Date : 2023-09-15 Omer Shlomovitz, Danit Atias-Varon, Dina Yagel, Ortal Barel, Hadas Shasha-Lavsky, Karl Skorecki, Aviva Eliyahu, Younes Bathish, Victor Frajewicki, Daniel Kushnir, Rinat Zaid, Tamar Paperna, Ayala Ofir, Marina Tchirkov, Kamal Hassan, Etty Kruzel, Khaled Khazim, Ronit Geron, Irit Weisman, Anaam Hanut, Asaf Vivante
Rationale & Objective Genetic etiologies have been identified among approximately 10% of adults with chronic kidney disease. However, data are lacking regarding the prevalence of monogenic etiologies especially among members of minority groups. The objective of this study was to characterize the genetic markers among members of an Israeli minority group with end-stage kidney disease (ESKD). Study Design
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Building Towards Clinical Translation: New Study Refines Genetic Architecture of IgA Nephropathy Am. J. Kidney Dis. (IF 13.2) Pub Date : 2023-09-15 Andrew O. Kearney, Edgar Lerma, Jennie Lin
Abstract not available
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An Unusual Case of Anti–Glomerular Basement Membrane Disease and PLA2R-Associated Membranous Nephropathy After Exposure to Hydrocarbons Am. J. Kidney Dis. (IF 13.2) Pub Date : 2023-09-14 Samuel Eley, Martha Catalina Morales-Alvarez, Vijay K. Vanguri, Bhavna Chopra
We present a rare case of a patient with toluene exposure manifesting as anti-GBM disease on a background of PLA2R-associated membranous nephropathy. A 23-year-old man presented to the emergency department with hypertension, headache, hemoptysis, anemia, acute kidney injury, glomerular hematuria, and proteinuria. He endorsed repeated exposure to toluene-containing products while repairing dirt bikes
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Lost in Translation: Why Are Rates of Hypertension Control Getting Worse Over Time? Am. J. Kidney Dis. (IF 13.2) Pub Date : 2023-09-14 Dena E. Rifkin
Treatment of hypertension to decrease rates of cardiovascular disease is the most well studied and most broadly applicable treatment in cardiovascular prevention. Blood pressure can be measured anywhere, not just in a physician’s office; medications are readily available, inexpensive, and have highly favorable benefit/harm ratios with relatively minimal side effects; stepped medication regimens can
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Associations of Baseline and Longitudinal Serum Uromodulin With Kidney Failure and Mortality: Results From the African American Study of Kidney Disease and Hypertension (AASK) Trial Am. J. Kidney Dis. (IF 13.2) Pub Date : 2023-09-09 Teresa K. Chen, Michelle M. Estrella, Lawrence J. Appel, Aditya L. Surapaneni, Anna Köttgen, Wassim Obeid, Chirag R. Parikh, Morgan E. Grams
Rational & Objective Uromodulin (UMOD) is the most abundant protein found in urine and has emerged as a promising biomarker of tubule health. Circulating UMOD is also detectable, but at lower levels. We evaluated whether serum UMOD levels were associated with risk of incident kidney failure with replacement therapy (KFRT) and mortality. Study Design Prospective cohort. Setting & Participants: Participants
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Using Relative Survival to Estimate the Burden of Kidney Failure Am. J. Kidney Dis. (IF 13.2) Pub Date : 2023-09-09 Margaret R. Stedman, Manjula Kurella Tamura, Glenn M. Chertow
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In Reply to “Comparison of Measured and Estimated GFR for Rivaroxaban Dosing in Hospitalized Older Adults” Am. J. Kidney Dis. (IF 13.2) Pub Date : 2023-09-09 Beini Lyu, Lesley A. Inker, Jung-Im Shin
Abstract not available
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Nuclear Magnetic Resonance–Based Metabolomics and Risk of CKD Am. J. Kidney Dis. (IF 13.2) Pub Date : 2023-09-09 Ting-Ting Geng, Jun-Xiang Chen, Qi Lu, Pei-Lu Wang, Peng-Fei Xia, Kai Zhu, Yue Li, Kun-Quan Guo, Kun Yang, Yun-Fei Liao, Yan-Feng Zhou, Gang Liu, An Pan
Rationale & Objective Chronic kidney disease (CKD) leads to lipid and metabolic abnormalities, but a comprehensive investigation of lipids, lipoprotein particles, and circulating metabolites associated with the risk of CKD is lacking. We examined the associations of nuclear magnetic resonance (NMR)-based metabolomics data with CKD risk in the UK Biobank study. Study Design Observational cohort study
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Comparison of Measured and Estimated GFR for Rivaroxaban Dosing in Hospitalized Older Adults Am. J. Kidney Dis. (IF 13.2) Pub Date : 2023-09-09 Esben Iversen, Mads Hornum, Morten Baltzer Houlind
Abstract not available
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Comparative Effectiveness of Alternative Treatment Approaches to Secondary Hyperparathyroidism in Patients Receiving Maintenance Hemodialysis: An Observational Trial Emulation Am. J. Kidney Dis. (IF 13.2) Pub Date : 2023-09-09 Alyssa Platt, Jonathan Wilson, Rasheeda Hall, Patti L. Ephraim, Sarah Morton, Tariq Shafi, Daniel E. Weiner, L. Ebony Boulware, Jane Pendergast, Julia J. Scialla
Rationale & Objective Optimal approaches to treat secondary hyperparathyroidism (SHPT) in patients on maintenance hemodialysis (HD) are not established in randomized controlled trials (RCTs). Study Design Two observational clinical trial emulations. Setting & Participants: Both emulations included adults receiving in-center HD from a national dialysis organization. Included patients had SHPT in the
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Association of COVID-19 Versus COVID-19 Vaccination With Kidney Function and Disease Activity in Primary Glomerular Disease: A Report of the Cure Glomerulonephropathy Study Am. J. Kidney Dis. (IF 13.2) Pub Date : 2023-08-31 Chia-shi Wang, Dorey A. Glenn, Margaret Helmuth, Abigail R. Smith, Andrew S. Bomback, Pietro A. Canetta, Gaia M. Coppock, Myda Khalid, Katherine R. Tuttle, Raed Bou-Matar, Larry A. Greenbaum, Bruce M. Robinson, Lawrence B. Holzman, William E. Smoyer, Michelle N. Rheault, Debbie Gipson, Laura H. Mariani
Rationale & Objective Patients with glomerular disease (GN) may be at increased risk of severe COVID-19, yet concerns over vaccines causing disease relapse may lead to vaccine hesitancy. We examined the associations of COVID-19 with longitudinal kidney function and proteinuria and compared these to similar associations with COVID-19 vaccination. Study Design Observational cohort study from July 1,
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Best Practice for Induction of Immunosuppression In Daratumumab Treated Patients Is To Be Determined. Am. J. Kidney Dis. (IF 13.2) Pub Date : 2023-08-30 Hatem Amer, Nelson Leung
Abstract not available
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Use of Analog and Human Insulin in a European Hemodialysis Cohort With Type 2 Diabetes: Associations With Mortality, Hospitalization, MACE, and Hypoglycemia Am. J. Kidney Dis. (IF 13.2) Pub Date : 2023-08-30 Thomas Ebert, Nosheen SattarMD, Marni Greig, Claudia Lamina, Marc Froissart, Kai-Uwe Eckardt, Jürgen Floege, Florian Kronenberg, Peter Stenvinkel, David C. Wheeler, James Fotheringham
Rationale & Objective Poor glycemic control may contribute to the high mortality rate in patients with type 2 diabetes receiving hemodialysis. Insulin type may influence glycemic control and its choice may be an opportunity to improve outcomes. This study assessed if treatment with analog insulin compared to human insulin is associated with different outcomes in people with type 2 diabetes and kidney
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Association Between Transplant Center Continuity and Access to a Second Kidney Transplant in Patients With Allograft Failure Am. J. Kidney Dis. (IF 13.2) Pub Date : 2023-08-30 David Emanuels, Timothy Copeland, Kirsten L. Johansen, Sandeep Brar, Charles E. McCulloch, Matthew Kadatz, John S. Gill, Elaine Ku
Abstract not available
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Impact of Using the Race-Free 2021 CKD-EPI Creatinine Equation on Treatment Effects on GFR-Based Endpoints in Clinical Trials Am. J. Kidney Dis. (IF 13.2) Pub Date : 2023-08-30 Juhi Chaudhari, Shiyuan Miao, Julia B. Lewis, Hiddo J.L. Heerspink, Andrew S. Levey, Lesley A. Inker
Abstract not available
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Outcomes of Integrated Home Dialysis Care: Results From the Canadian Organ Replacement Register Am. J. Kidney Dis. (IF 13.2) Pub Date : 2023-08-30 Louis-Charles Desbiens, Karthik K. Tennankore, Rémi Goupil, Jeffrey Perl, Emilie Trinh, Christopher T. Chan, Annie-Claire Nadeau-Fredette
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Best Practice for Induction of Immunosuppression in Patients Treated With Daratumumab Is To Be Determined Am. J. Kidney Dis. (IF 13.2) Pub Date : 2023-08-29 Hatem Amer, Nelson Leung
Abstract not available
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It’s All Relative: Donor-Recipient Relationships, Disease Heritability, and Kidney Transplant Outcomes Am. J. Kidney Dis. (IF 13.2) Pub Date : 2023-08-26 S. Ali Husain, R. John Crew
Abstract not available
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Erratum Regarding “Prediction of Mortality and Major Adverse Kidney Events in Critically Ill Patients With Acute Kidney Injury” [Am J Kidney Dis. 2023;81(1):36-47] Am. J. Kidney Dis. (IF 13.2) Pub Date : 2023-08-21
Abstract not available
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Erratum Regarding “A New Panel-Estimated GFR, Including β2-Microglobulin and β-Trace Protein and Not Including Race, Developed in a Diverse Population” [Am J Kidney Dis. 2021;77(5):673-683] Am. J. Kidney Dis. (IF 13.2) Pub Date : 2023-08-21
Abstract not available
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Predicting Kidney Failure With the Kidney Failure Risk Equation: Time to Rethink Probabilities Am. J. Kidney Dis. (IF 13.2) Pub Date : 2023-08-17 Roemer J. Janse, Merel van Diepen, Chava L. Ramspek
Abstract not available
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Pruritus in Hemodialysis Patients: Longitudinal Associations With Clinical and Patient-Reported Outcomes Am. J. Kidney Dis. (IF 13.2) Pub Date : 2023-08-16 Nidhi Sukul, Junhui Zhao, Ronald L. Pisoni, Sebastian Walpen, Thilo Schaufler, Elham Asgari, Fitsum Guebre-Egziabher, Li Zho, Mohammed Abdulrahman Al-Ghonaim, Kosaku Nitta, Bruce M. Robinson, Angelo Karaboyas
Rationale & Objective Cross-sectional studies have reported an association of chronic kidney disease-associated pruritus (CKD-aP) with adverse clinical events and patient-reported outcomes (PROs). We studied the longitudinal associations between changes in CKD-aP and clinical outcomes among patients receiving maintenance hemodialysis. Study Design Prospective cohort study. Setting & Participants 7976
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Pandemic Preparedness: Let’s Be Ready for the Patient and Their Caregiver Am. J. Kidney Dis. (IF 13.2) Pub Date : 2023-08-13 Suzanne Watnick
Abstract not available
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Kidney Stone Pathophysiology, Evaluation and Management: Core Curriculum 2023 Am. J. Kidney Dis. (IF 13.2) Pub Date : 2023-08-09 Shani Shastri, Jiten Patel, Kamalanathan K. Sambandam, Eleanor D. Lederer
Kidney stone disease, also known as nephrolithiasis or urolithiasis, is a disorder in which urinary solutes precipitate to form aggregates of crystalline material in the urinary space. The incidence of nephrolithiasis has been increasing, and the demographics have been evolving. Once viewed as a limited disease with intermittent exacerbations that are simply managed by urologists, nephrolithiasis is
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Microscopic Kidney Disease in Tuberous Sclerosis Complex and Treatment With mTOR Inhibition Am. J. Kidney Dis. (IF 13.2) Pub Date : 2023-07-31 Jami Kronick, Manal Y. Gabril, Andrew A. House
Declining kidney function in Tuberous Sclerosis Complex (TSC) is often attributed to large lesions, including angiomyolipomas (AMLs) and cysts, that encroach on the normal parenchyma or that require intervention and loss of parenchyma from surgical debulking or embolization. Consequently, research on inhibitors of the mammalian target of rapamycin (mTOR), a protein complex implicated in TSC pathophysiology
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Novel Therapies in Diabetic Kidney Disease and Risk of Hyperkalemia: A Review of the Evidence From Clinical Trials Am. J. Kidney Dis. (IF 13.2) Pub Date : 2023-07-29 Rehab B. Albakr, Vikas S. Sridhar, David Z.I. Cherney
Concerns about hyperkalemia may result in the under-utilization of established and novel therapies that improve kidney and/or cardiovascular outcomes in patients with type 2 diabetes (T2D) and chronic kidney disease (CKD). Hyperkalemia-related issues are of particular relevance in patients with CKD who are commonly on other hyperkalemia-inducing agents such as renin-angiotensin-aldosterone system inhibitors
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Incidence of and Risk Factors for Active Tuberculosis Disease in Individuals With Glomerular Disease: A Canadian Cohort Study Am. J. Kidney Dis. (IF 13.2) Pub Date : 2023-07-28 Mark Canney, Heather M. Gunning, James C. Johnston, Dilshani Induruwage, Yuyan Zheng, Sean J. Barbour
Rationale & Objective Kidney failure is an established risk factor for active tuberculosis (TB) but the risk of TB has not been reported in specific kidney diseases. We sought to determine the incidence of and risk factors for active TB in patients with glomerular disease. Study Design Observational cohort study. Setting & Participants A provincial kidney pathology registry (2000-2012) was used to
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Shared Decision Making in Health Care Visits for CKD: Patients’ Decisional Role Preferences and Experiences Am. J. Kidney Dis. (IF 13.2) Pub Date : 2023-07-28 Dorinde E.M. van der Horst, Nieneke Hofstra, Cornelia F. van Uden-Kraan, Anne M. Stiggelbout, Marinus A. van den Dorpel, Arwen H. Pieterse, Willem Jan W. Bos
Rationale & Objective Research on shared decision making (SDM) in chronic kidney disease (CKD) has focused almost exclusively on the modality of kidney replacement treatment. We aimed to explore what other CKD decisions are recognized by patients, what their preferences and experiences are regarding these decisions, and how decisions are made during their interactions with medical care professionals
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Role of Anemia in Dementia Risk Among Veterans With Incident CKD Am. J. Kidney Dis. (IF 13.2) Pub Date : 2023-07-28 Alain K. Koyama, Robert Nee, Wei Yu, Devasmita Choudhury, Fei Heng, Alfred K. Cheung, Keith C. Norris, Monique E. Cho, Guofen Yan
Rationale & Objective While some evidence exists of increased dementia risk from anemia, it is unclear if this association persists among adults with CKD. Anemia may be a key marker for dementia among adults with CKD. We therefore evaluated if anemia is associated with an increased risk of dementia among adults with CKD. Study Design Retrospective cohort study. Setting & Participants The study included