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Trajectories of Physical Resilience Among Older Veterans With Stage 4 CKD Am. J. Kidney Dis. (IF 13.2) Pub Date : 2024-03-12 C. Barrett Bowling MD MSPH, Theodore S.Z. Berkowitz MS, Brett T. Burrows PhD, Jessica E. Ma MD, Heather E. Whitson MD MHS, Battista Smith MPH, Steven D. Crowley MD, Virginia Wang PhD, Matthew L. Maciejewski PhD, Maren K. Olsen PhD
Although functional impairment is common among older adults with chronic kidney disease (CKD), functional reserve before an acute health event and physical resilience after have not been characterized in this population. The purpose of this study was to identify distinct patterns of physical function before and after an acute health event among older Veterans with Stage 4 CKD. Prospective cohort study
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Hereditary Transthyretin Amyloidosis: Impact of Classic and New Treatments on Kidney Function Am. J. Kidney Dis. (IF 13.2) Pub Date : 2024-03-12 Evelyn Meléndrez-Balcázar BM, Karla Aranda-Vela BM, Alberto Cervantes-Hernández BM, Samuel López-Cureño BM
Hereditary transthyretin amyloidosis (ATTRv) is a rare, progressive, and life-threatening disease caused by misfolded transthyretin (TTR) proteins that aggregate as abnormal amyloid fibrils and accumulate throughout the body. The kidney is one of the main organs affected in amyloid light chain (AL) amyloidosis and ATTRv amyloidosis. The most common clinical presentation is proteinuria, which consists
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EKFC Versus CKD-EPI Equation in Young Adults? No Definitive Answer Am. J. Kidney Dis. (IF 13.2) Pub Date : 2024-03-12 Pierre Delanaye MD PhD, Hans Pottel PhD
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Gestational Exposure to Maternal Systemic Glucocorticoids and Childhood Risk of CKD Am. J. Kidney Dis. (IF 13.2) Pub Date : 2024-03-11 You-Lin Tain, Lung-Chih Li, Hsiao-Ching Kuo, Chien-Ning Hsu
The potential effects of antenatal glucocorticoid exposure on the health of children are unclear. We examined the association of gestational exposure to maternal systemic glucocorticoids (SG) and the risk of developing chronic kidney disease (CKD) in childhood. Retrospective cohort study. Newborns cared for at the largest healthcare delivery system in Taiwan between 2004 and 2018. Maternal prescriptions
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Thiazides for Nephrolithiasis Prevention: Written in Stone? Am. J. Kidney Dis. (IF 13.2) Pub Date : 2024-03-08 Anna L. Zisman MD
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Designing an Implementable Clinical Prediction Model for Near-Term Mortality and Long-Term Survival in Patients on Maintenance Hemodialysis Am. J. Kidney Dis. (IF 13.2) Pub Date : 2024-02-21 Benjamin A. Goldstein, Chun Xu, Jonathan Wilson, Ricardo Henao, Patti L. Ephraim, Daniel E. Weiner, Tariq Shafi, Julia J. Scialla
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An Unusual Case of Bone Pain, Hypophosphatemia, and a Gastric Mass: A Quiz Am. J. Kidney Dis. (IF 13.2) Pub Date : 2024-02-21 Xiang Li, Dongsheng Cheng, Zhenkui Sun, Qiong Jiao, Chun Wang, Ying Fan
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Magnesium Disorders: Core Curriculum 2024 Am. J. Kidney Dis. (IF 13.2) Pub Date : 2024-02-17 Emmanuel A. Adomako, Alan S.L. Yu
Magnesium is ubiquitous in nature. It sits at the origin of the food chain, occupying the center of chlorophyl in plants. In humans, magnesium is critical to diverse molecular and catalytic processes, including energy transfer and maintenance of the genome. Despite its abundance, hypomagnesemia is common and often goes undiagnosed. This is in spite of epidemiologic data linking low magnesium with chronic
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Sodium/Glucose Cotransporter 2 Inhibitors and Magnesium Homeostasis Am. J. Kidney Dis. (IF 13.2) Pub Date : 2024-02-17 Chintan V. Shah, Matthew A. Sparks, Chien-Te Lee
Magnesium (Mg), also known as “the forgotten ion,” is the second most abundant intracellular cation and is essential in a broad range of intracellular physiological and biochemical reactions. Its deficiency, hypomagnesemia (Mg<1.8mg/dL), is a prevalent condition and routinely poses challenges in its management in clinical practice. Sodium/glucose cotransporter 2 (SGLT2) inhibitors have emerged as a
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Time-Varying Proteinuria and Progression of IgA Nephropathy: A Cohort Study Am. J. Kidney Dis. (IF 13.2) Pub Date : 2024-02-15 Chen Tang, Pei Chen, Feng-Lei Si, Ji-Cheng Lv, Su-Fang Shi, Xu-Jie Zhou, Li-Jun Liu, Hong Zhang
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Dialysis Catheter Tip Design and Dysfunction: An Unsolved Challenge Am. J. Kidney Dis. (IF 13.2) Pub Date : 2024-02-15 Pallavi Prasad, Tushar J. Vachharajani
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Continuous Kidney Replacement Therapy and Survival in Children and Young Adults: Findings From the Multi-National WE-ROCK Collaborative Am. J. Kidney Dis. (IF 13.2) Pub Date : 2024-02-15 Michelle C. Starr, Katja M. Gist, Huaiyu Zang, Nicholas J. Ollberding, Shanthi Balani, Andrea Cappoli, Eileen Ciccia, Catherine Joseph, Aadil Kakajiwala, Aaron Kessel, Melissa Muff-Luett, María J. Santiago Lozano, Matthew Pinto, Stephanie Reynaud, Sonia Solomon, Cara Slagle, Rachana Srivastava, Weiwen V. Shih, Tennille Webb, Shina Menon, Emily Ahern, Ayse Akcan Arikan, Issa Alhamoud, Rashid Alobaidi
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APOL1 Nephropathy Risk Variants Through the Life Course: A Review Am. J. Kidney Dis. (IF 13.2) Pub Date : 2024-02-09 Ai Itoku, Jaya Isaac, Scott Wilson, Kimberly Reidy, Frederick Kaskel
Two variant alleles of the gene , known as risk variants (RVs), are a major contributor to kidney disease burden in those of African descent. The protein contributes to innate immunity and may protect against trypanosoma, human immunodeficiency virus, salmonella, and leishmaniasis. However, the effects of carrying one or more RVs contribute to a variety of disease processes starting as early as and
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A “Fit for Purpose” Approach to CKD Classification? Am. J. Kidney Dis. (IF 13.2) Pub Date : 2024-02-02 Jin Ho Hwang, Chi-yuan Hsu
Abstract not available
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How Much Patient Autonomy Is Too Much? Am. J. Kidney Dis. (IF 13.2) Pub Date : 2024-01-30 Chia-Ter Chao
Abstract not available
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Aptamer-Based Proteomics in CKD Am. J. Kidney Dis. (IF 13.2) Pub Date : 2024-01-27 Taesoo Kim, Eugene P. Rhee
Abstract not available
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Association of Kidney Cysts With Progressive CKD After Radical Nephrectomy Am. J. Kidney Dis. (IF 13.2) Pub Date : 2024-01-26 Moldovan Sabov, Aleksandar Denic, Aidan F. Mullan, Anthony C. Luehrs, Timothy L. Kline, Bradley J. Erickson, Theodora A. Potretzke, R. Houston Thompson, Vidit Sharma, Peter C. Harris, Andrew D. Rule
Rationale & Objective Simple kidney cysts are common and usually considered of limited clinical relevance. They are associated with older age and lower glomerular filtration rate (GFR), but little is known of their association with progressive chronic kidney disease (CKD) which was the focus of this study. Study Design Observational cohort study. Setting & Participants Patients with pre-surgical CT
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Potentially Inappropriately Medication Prescriptions Among Medicare Patients Receiving Hemodialysis Am. J. Kidney Dis. (IF 13.2) Pub Date : 2024-01-23 Armando Silva Almodovar, Macarius Donneyong, Eric Seiber, Milap C. Nahata
Abstract not available
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Quantity Versus Quality of Anti–Phospholipase A2 Receptor 1 Autoantibodies in the Assessment of Clinical Outcome in Membranous Nephropathy: The Debate Continues Am. J. Kidney Dis. (IF 13.2) Pub Date : 2024-01-22 Laurence H. Beck
Abstract not available
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Metabolites Associated With Uremic Symptoms in Patients With CKD: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study Am. J. Kidney Dis. (IF 13.2) Pub Date : 2024-01-23 Kendra E. Wulczyn, Tariq Shafi, Amanda Anderson, Hernan Rincon-Choles, Clary B. Clish, Michelle Denburg, Harold I. Feldman, Jiang He, Chi-yuan Hsu, Tanika Kelly, Paul L. Kimmel, Rupal Mehta, Robert G. Nelson, Vasan Ramachandran, Ana Ricardo, Vallabh O. Shah, Anand Srivastava, Dawei Xie, Eugene P. Rhee, Sahir Kalim, Tracy Rankin
Rationale & Objective The toxins contributing to uremic symptoms in patients with CKD are unknown. We sought to apply complementary statistical modeling approaches to data from untargeted plasma metabolomic profiling to identify solutes associated with uremic symptoms in patients with CKD. Study Design Cross-sectional. Setting & Participants 1,761 Chronic Renal Insufficiency Cohort (CRIC) participants
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Monoclonal Immunoglobulin Crystalline Membranous Nephropathy Am. J. Kidney Dis. (IF 13.2) Pub Date : 2024-01-23 Salvatore E. Mignano, Virginie Pascal, Nnaemezie E. Odioemene, William Forehand, Vincent Javaugue, Samar M. Said, Sanjeev Sethi, Christophe Sirac, Samih H. Nasr
Monoclonal immunoglobulin (MIg) crystalline nephropathies are rare lesions resulting from precipitation of MIgs in the kidney as intracellular or extracellular crystals. We describe a patient with multiple myeloma (IgGλ) and diabetes who presented with nephrotic range proteinuria. Kidney biopsy revealed membranous nephropathy superimposed on diabetic glomerulosclerosis. Glomeruli were negative for
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Reducing Elevated Parathyroid Hormone to Protect Bone Strength in End-Stage Kidney Disease Am. J. Kidney Dis. (IF 13.2) Pub Date : 2024-01-25 Tamara Isakova, Thomas L. Nickolas
Abstract not available
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Improvements in Kidney Outcomes Over the Years: Reason for Optimism but a Challenge for Trialists Am. J. Kidney Dis. (IF 13.2) Pub Date : 2024-01-23 Doreen Zhu, Parminder K. Judge, Richard Haynes
Abstract not available
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Implantation Biopsy in Living-Donor Kidney Transplantation: Expectations, Utility, and Limitations Am. J. Kidney Dis. (IF 13.2) Pub Date : 2024-01-20 Junji Yamauchi, Isaac E. Hall, Divya Raghavan
Abstract not available
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Toxic Nephropathies of the Tubulointerstitium: Core Curriculum 2024 Am. J. Kidney Dis. (IF 13.2) Pub Date : 2024-01-19 Namrata Krishnan, Dennis G. Moledina, Mark A. Perazella
Toxic nephropathies are a clinically common group of disorders characterized by toxin-induced renal injury that can affect the glomerulus, vasculature, or tubulointerstitium. Various endogenous (eg, myoglobin, hemoglobin, monoclonal light chains, and lysozymes) and exogenous toxins (eg, therapeutic drugs, herbal medications, heavy metals, radiocontrast, intoxicants, and environmental exposures) have
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Navigating Living Kidney Donation and Transplantation Among South Asian Canadians: The ACTION Project Am. J. Kidney Dis. (IF 13.2) Pub Date : 2024-01-18 Reetinder Kaur, Kara Schick-Makaroff, Phuc Dang, Ayumi Sasaki, Paula Neves, Istvan Mucsi, Jagbir Gill
Rationale & Objective South Asian (SA) Canadians with kidney failure have a 50-77% lower likelihood of kidney transplantation and are less likely to identify potential living kidney donors (LDs). This study aimed to identify, health system, patient, and community level barriers and facilitators for accessing living donor kidney transplantation (LDKT) in the SA community to inform the development of
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Rapidly Rising Serum Creatinine in a Patient With Colorectal Adenocarcinoma and Eosinophilia: A Quiz Am. J. Kidney Dis. (IF 13.2) Pub Date : 2024-01-19 Athiphat Banjongjit, Vorachai Ratanatharathorn, Piyanut Mahanupap, Winyou Mitarnun
Abstract not available
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Anticoagulation for Atrial Fibrillation in Advanced CKD: Can Observational Studies Provide the Answer? Am. J. Kidney Dis. (IF 13.2) Pub Date : 2024-01-17 Daniel E. Weiner, Mark J. Sarnak
Abstract not available
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Cystatin C to Creatinine Ratio and Measured GFR in Hospitalized Older Adults Am. J. Kidney Dis. (IF 13.2) Pub Date : 2024-01-13 Morten Baltzer Houlind, Ove Andersen, Esben Iversen
Abstract not available
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In Reply to “Cystatin C to Creatinine Ratio and Measured GFR in Hospitalized Older Adults” Am. J. Kidney Dis. (IF 13.2) Pub Date : 2024-01-13 Anders O. Grubb, Anna Åkesson, Anders Christensson
Abstract not available
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Patients’ Perspectives on Health-Related Social Needs and Recommendations for Interventions: A Qualitative Study Am. J. Kidney Dis. (IF 13.2) Pub Date : 2024-01-11 Tessa K. Novick, Michelle Osuna, Caroline Emery, Francisco Barrios, Daniel Ramirez, Deidra C. Crews, Elizabeth A. Jacobs
Rationale & Objective People with low socioeconomic status are disproportionately affected by kidney failure, and their adverse outcomes may stem from unmet health-related social needs. This study explored hemodialysis patient perspectives on health-related social needs and recommendations for intervention. Study Design Qualitative study using semi-structured interviews. Settings & Participants Thirty-two
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Challenges to Informed, Patient-Centered, and Shared Decision Making for Treatment of Kidney Failure in Older Adults Am. J. Kidney Dis. (IF 13.2) Pub Date : 2024-01-11 Elizabeth Kiernan, Susan P.Y. Wong
Abstract not available
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A Deep Intronic PKHD1 Variant Identified by SpliceAI in a Deceased Neonate With Autosomal Recessive Polycystic Kidney Disease Am. J. Kidney Dis. (IF 13.2) Pub Date : 2024-01-10 Felix Richter, Kayleigh D. Rutherford, Anisha J. Cooke, Malorie Meshkati, Vanessa Eddy-Abrams, Daniel Greene, Jordana Kosowsky, Yeaji Park, Surabhi Aggarwal, Rebecca J. Burke, Weili Chang, Jillian Connors, Peter J. Giannone, Thomas Hays, Divya Khattar, Mark Polak, Liana Senaldi, Matthew Smith-Raska, Shanthy Sridhar, Laurie Steiner, Ernest Turro
The etiologies of newborn deaths in neonatal intensive care units usually remain unknown, even following genetic testing. Whole-genome sequencing, combined with artificial intelligence-based methods for predicting the effects of non-coding variants, provide an avenue for resolving these deaths. Using one such method, SpliceAI, we identified a maternally inherited deep intronic PKHD1 splice variant
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Hospital Garden Am. J. Kidney Dis. (IF 13.2) Pub Date : 2024-01-10 Tarek Zieneldien BS
Abstract not available
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Chronic Hyponatremia and Brain Structure and Function Before and After Treatment Am. J. Kidney Dis. (IF 13.2) Pub Date : 2024-01-04 Victor Suárez, Rosanne Picotin, Ronja Faßbender, Hannes Gramespacher, Stefan Haneder, Thorsten Persigehl, Polina Todorova, Matthias Johannes Hackl, Oezguer A. Onur, Nils Richter, Volker Burst
Rationale & Objective Hyponatremia is the most common electrolyte disorder and is associated with significant morbidity and mortality. This study investigated neurocognitive impairment, brain volume, and alterations in MRI-based measures of cerebral function in patients before and after treatment for hyponatremia. Study Design Prospective cohort study. Setting & Participants Patients with presumed
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Difference Between Estimated GFR Based on Cystatin C Versus Creatinine and Incident Atrial Fibrillation: A Cohort Study of the UK Biobank Am. J. Kidney Dis. (IF 13.2) Pub Date : 2024-01-01 Ga Young Heo, Hee Byung Koh, Chan-Young Jung, Jung Tak Park, Seung Hyeok Han, Tae-Hyun Yoo, Shin-Wook Kang, Hyung Woo Kim
Rationale & Objective The difference between cystatin C-based and creatinine-based estimated glomerular filtration rate (eGFRdiff) has been suggested to reflect factors distinct from kidney function that are associated with cardiovascular risk. However, the association between eGFRdiff and atrial fibrillation (AF) risk has not been extensively evaluated. Study Design Prospective cohort study. Setting
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Atypical Anti-Glomerular Basement Membrane Nephritis: A Case Series From the French Nephropathology Group Am. J. Kidney Dis. (IF 13.2) Pub Date : 2024-01-01 Bertrand Chauveau, Jean-Baptiste Gibier, Jérôme Olagne, Antoine Morel, Selda Aydin, Stephen P. McAdoo, Nicolas Viallet, Hélène Perrochia, Emilie Pambrun, Virginie Royal, Nathalie Demoulin, Jean-Louis Kemeny, Carole Philipponnet, Alexandre Hertig, Jean-Jacques Boffa, Emmanuelle Plaisier, Camille Domenger, Isabelle Brochériou, Clément Deltombe, Jean-Paul Duong Van Huyen, Vincent Vuiblet
Rationale & Objective Atypical anti-glomerular basement membrane (GBM) nephritis is characterized by a bright linear immunoglobulin staining along the GBM by immunofluorescence without a diffuse crescentic glomerulonephritis nor serum anti-GBM antibodies by conventional ELISA. We characterized a series of patients with atypical anti-GBM disease. Study Design Case series. Setting & Participants Patients
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Infections Following Kidney Transplantation After Exposure to Immunosuppression for Treatment of Glomerulonephritis Am. J. Kidney Dis. (IF 13.2) Pub Date : 2023-12-30 David Massicotte-Azarniouch, Randal K. Detwiler, Yichun Hu, Ronald J. Falk, Manish K. Saha, David van Duin, Susan L. Hogan, Vimal K. Derebail
Rationale & Objective Kidney transplant patients with glomerulonephritis (GN) as their native disease commonly have received pre-transplant immunosuppression (PTI). This may contribute to the immunosuppression burden potentially increasing the risk for infections following transplantation. Study Design Single-center, retrospective cohort study. Setting & Participants: Recipients of a kidney transplant
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Diabetes Insipidus in Deceased Donors and Outcomes in Kidney Transplant Recipients Am. J. Kidney Dis. (IF 13.2) Pub Date : 2023-12-30 Miguel Nunez, James Gardner, Shareef Syed, Allison Webber, Jun Shoji, Timothy P. Copeland, Charles E. McCulloch, Elaine Ku, Garrett R. Roll
Abstract not available
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Disparities in Kidney Transplant Waitlisting Among Young Patients Without Medical Comorbidities Am. J. Kidney Dis. (IF 13.2) Pub Date : 2023-12-26 Kelsey M. Drewry, Jade Buford, Rachel E. Patzer
Abstract not available
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Anti–Phospholipase A2 Receptor 1 and Anti–Cysteine Rich Antibodies, Domain Recognition and Rituximab Efficacy in Membranous Nephropathy: A Prospective Cohort Study Am. J. Kidney Dis. (IF 13.2) Pub Date : 2023-12-25 Piero Ruggenenti, Linda Reinhard, Barbara Ruggiero, Annalisa Perna, Luca Perico, Tobia Peracchi, Diego Fidone, Alessia Gennarini, Ariela Benigni, Monica Cortinovis, Elion Hoxha, Giuseppe Remuzzi
Rationale & Objective Proteinuria and anti-phospholipase A2 receptor 1 (anti-PLA2R1) antibody titers are associated with primary membranous nephropathy (MN) outcomes. We evaluated the association of antibodies against the cysteine-rich (CysR) and C-type lectin 1, 7, and 8 (CTLD1, CTLD7, and CTLD8) domains of PLA2R1 with MN outcomes. Study Design Prospective cohort study. Setting & Participants One-hundred-thirteen
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Kidney Function Measures and Mortality: A Mendelian Randomization Study Am. J. Kidney Dis. (IF 13.2) Pub Date : 2023-12-25 Ying Shan, Jingwen Zhang, Yueqi Lu, Jinlan Liao, Yuyang Liu, Liang Dai, Jing Li, Congying Song, Guobin Su, Sara Hägg, Zuying Xiong, Dorothea Nitsch, Juan Jesus Carrero, Xiaoyan Huang
Rationale & Objective Individuals with a low estimated glomerular filtration rate (eGFR) are at a high risk of death. Yet, the causes underpinning this association are largely uncertain. This study aimed to assess the causal relationship of low eGFR with all-cause and cause-specific mortality. Study Design Retrospective cohort study incorporating Mendelian randomization (MR). Setting & Participants
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Tips for Testing Adults With Suspected Genetic Kidney Disease Am. J. Kidney Dis. (IF 13.2) Pub Date : 2023-12-24 Judy Savige
Genetic kidney disease is common but often unrecognized. It accounts for most cystic kidney diseases and tubulopathies, many forms of CAKUT, and some glomerulopathies. Genetic kidney disease is typically suspected where the disease usually has a genetic basis, or there is another affected family member, a young age at onset, or extra- renal involvement, but there are also many exceptions to these guidelines
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Recent Advances in Kidney Replacement Therapy in Infants: A Review Am. J. Kidney Dis. (IF 13.2) Pub Date : 2023-12-24 Cara Slagle, David Askenazi, Michelle Starr
Kidney replacement therapy (KRT) is used to treat children and adults with acute kidney injury (AKI), fluid overload, kidney failure, inborn errors of metabolism, and severe electrolyte abnormalities. Peritoneal dialysis and extracorporeal hemodialysis/filtration can be performed for different durations (intermittent, prolonged intermittent, and continuous) through either adaptation of adult devices
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KDOQI Commentary on the KDIGO 2022 Update to the Clinical Practice Guideline for Diabetes Management in CKD Am. J. Kidney Dis. (IF 13.2) Pub Date : 2023-12-21 Amy K. Mottl, Susanne B. Nicholas
The Kidney Disease: Improving Global Outcomes (KDIGO) guideline for diabetes management in chronic kidney disease (CKD) was updated in 2022, just 2 years after the previous update. The need for this rapid update is reflective of the recent and unprecedented positive results of numerous clinical trials aimed at reducing kidney and cardiovascular morbidity and mortality in people with diabetes. The Kidney
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My Road to Advocacy as a Person Living With Kidney Failure Am. J. Kidney Dis. (IF 13.2) Pub Date : 2023-12-21 Shanthi Rajmohan
Abstract not available
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