-
Differential Risks of Exposure to Acrylamide in Adult Asthma Clusters Allergy (IF 12.6) Pub Date : 2025-02-15 Yuan‐Ting Hsu, Chao‐Chien Wu, Chin‐Chou Wang, Chau‐Chyun Sheu, Yi‐Hsin Yang, Ming‐Yen Cheng, Ruay‐Sheng Lai, Meng‐Hsuan Cheng, Huang‐Chi Chen, Chih‐Jen Yang, Chien‐Jen Wang, Huei‐Ju Liu, Hua‐Ling Chen, Chih‐Hsing Hung, Chon‐Lin Lee, Ming‐Shyan Huang, Shau‐Ku Huang
-
Intralymphatic Administration of Naked mRNA Induces Allergen‐Specific IgG, Promotes Th1 Responses and Reduces Anaphylactic Potential Allergy (IF 12.6) Pub Date : 2025-02-13 Marta Paolucci, Frida A. M. Nilsson, Agathe Duda, Marina Tusup, Mustafa Diken, Thomas M. Kündig, Pål Johansen
-
Healthcare Resource Utilisation and Costs of Mepolizumab Initiation: A 5‐Year National Cohort Analysis Allergy (IF 12.6) Pub Date : 2025-02-12 Arnaud Bourdin, Erika Nogue, Carey M. Suehs, Nicolas Malafaye, Joana Pissarra, Isabelle Vachier, Engi Ahmed, Nicolas Molinari
-
Real‐World Efficacy and Safety of Abrocitinib in Chinese Atopic Dermatitis Patients: A Single‐Center Prospective Study Allergy (IF 12.6) Pub Date : 2025-02-11 Zheng Li, Yu Wang, Yuemeng Wu, Huibin Yin, Shangshang Wang, Hao Wu, Haihong Qin, Ce Wang, Xu Yao, Wei Li, Chaoying Gu
BackgroundPhase 3 trials have demonstrated the efficacy and safety of abrocitinib for atopic dermatitis (AD), but real‐world evidence remains limited.MethodsThis study prospectively enrolled 117 moderate‐to‐severe AD patients at Huashan Hospital, Shanghai, China. Physician‐ and patient‐reported outcomes were evaluated at multiple time points. Blood eosinophil counts, serum IgE, and 24 cytokines/chemokines
-
Correspondence: “Challenging the Frontier: Bridging Systemic Biomarkers and Small Airway Dynamics in Severe Asthma Management” Allergy (IF 12.6) Pub Date : 2025-02-11 Ourania S. Kotsiou, Paraskevi Kirgou, Dimitra Siachpazidou, Konstantinos Bartziokas, Konstantinos Tourlakopoulos, Foteini Malli, Maria Pinaka, Zoe Daniil, Konstantinos I. Gourgoulianis
-
A Distinct Genetic Signature Differentiates Inflamed and Noninflamed Fibrotic Tissues in Eosinophilic Esophagitis Patients. Allergy (IF 12.6) Pub Date : 2025-02-07 Emilie Gueguen,Yasser Morsy,Luc Biedermann,Alex Straumann,,Michael Scharl,Marcin Wawrzyniak
-
-
Almost Half of the Dupilumab-Treated Patients With Severe CRS With Nasal Polyps Achieve Remission in One Year. Allergy (IF 12.6) Pub Date : 2025-02-06 Josje J Otten,Hester E Elzinga,Rik J L van der Lans,Wytske J Fokkens,Sietze Reitsma,
-
Correlation Between N‐Glycan GnGnXF3 and the Allergic Immune Response Against Juniperus ashei Pollen Allergy (IF 12.6) Pub Date : 2025-02-06 Javier Álvarez, Nuria Parody, David Calzada, Tamara Aranda, Ana Renshaw, Sonia Serna, Niels Reichardt, Juan María Beitia, David González‐de‐Olano, Javier Dominguez‐Ortega, Jerónimo Carnés
BackgroundCupressaceae pollen increasingly causes respiratory allergies worldwide. Carbohydrates are abundant in extracts of these pollens, and the associated allergens are highly glycosylated. However, the contribution of saccharides to the allergenicity of these species remains unknown.MethodsJuniperus ashei pollen extract was deglycosylated and characterised using SDS‐PAGE and immunoblotting. Additionally
-
Epigenome‐Wide Association Study of Asthma Exacerbations in Europeans Allergy (IF 12.6) Pub Date : 2025-02-05 Elena Martin‐Gonzalez, Javier Perez‐Garcia, Esther Herrera‐Luis, Mario Martin‐Almeida, Simon Kebede‐Merid, Natalia Hernandez‐Pacheco, Fabian Lorenzo‐Diaz, Ruperto González‐Pérez, Olaia Sardón, José M. Hernández‐Pérez, Paloma Poza‐Guedes, Inmaculada Sánchez‐Machín, Elena Mederos‐Luis, Paula Corcuera, Leyre López‐Fernández, Berta Román‐Bernal, Antoaneta A. Toncheva, Susanne Harner, Christine Wolff, Susanne
BackgroundAsthma exacerbations (AEs) represent the major contributor to the global asthma burden. Although genetic and environmental factors have been associated with AEs, the role of epigenetics remains uncovered.ObjectiveThis study aimed to identify whole blood DNA methylation (DNAm) markers associated with AEs in Europeans.MethodsDNAm was assessed in 406 blood samples from Spanish individuals using
-
Six Injections of Modified Adjuvanted PQ Grass Is Effective and Well-Tolerated in a Pivotal Phase III Trial. Allergy (IF 12.6) Pub Date : 2025-02-04 Stefan Zielen,Jonathan A Bernstein,Gunter J Sturm,Marek Jutel,Oliver Pfaar,,Mohamed H Shamji,Ralph Mösges,Markus Berger,Uwe E Berger,Lawrence DuBuske,Janice A Layhadi,Ludger Klimek,Markus Ollert,Murray A Skinner,Matthias F Kramer,Pieter-Jan de Kam
BACKGROUND PQ Grass 27600 SU (PQ Grass) cumulative dose is a pre-seasonal, six-injection, aluminium-free, modified subcutaneous immunotherapy product under development for the treatment of allergic rhinitis (AR). A pivotal Phase III randomised double-blind, placebo-controlled clinical trial was performed to evaluate the efficacy and safety of PQ Grass in subjects with seasonal AR. METHODS An adaptive
-
A Phenotypically Distinct Human Th2 Cell Subpopulation Is Associated With Development of Allergic Disorders in Infancy Allergy (IF 12.6) Pub Date : 2025-02-03 Catherine R. Pizzarello, Courtney M. Jackson, Katherine Herman, Antti E. Seppo, Jonathan Rebhahn, Tyler Scherzi, M. Cecilia Berin, R. John Looney, Tim R. Mosmann, Kirsi M. Järvinen
BackgroundLittle is known about the ontogeny of T cell immunity during infancy in farming and urban lifestyles due to the lack of immunophenotyping in such birth cohorts.MethodsTwo birth cohorts (farming and urban) at differing risks and rates of allergic diseases were compared. Blood mononuclear cells were collected from infants at birth, and 6 and 12 months of age. Full spectrum flow cytometry, followed
-
-
Association Between Heat Exposure and Anaphylaxis in Japan: A Time‐Stratified Case‐Crossover Study Allergy (IF 12.6) Pub Date : 2025-02-01 Nobutoshi Nawa, Hisaaki Nishimura, Kiyohide Fushimi, Takeo Fujiwara
-
Oral and Gut Microbial Hubs Associated With Reaction Threshold Interact With Circulating Immune Factors in Peanut Allergy Allergy (IF 12.6) Pub Date : 2025-01-31 Lingdi Zhang, Yoojin Chun, Galina Grishina, Tracy Lo, Kyle Reed, Julie Wang, Scott Sicherer, M. Cecilia Berin, Supinda Bunyavanich
BackgroundAmong peanut‐allergic individuals, there is high variability in the amount of peanut that triggers reactions (i.e., reaction threshold) that is not predictable or well‐understood. We conducted this study to characterize relationships between the oral and gut microbiomes and systemic processes associated with reaction threshold in peanut allergy (PA).MethodsIn a cohort of 120 children with
-
Dichotomous STAT5 and STAT6 Activation in T Cells Reflects Cytokine Shifts Between Blood and Skin in Atopic Dermatitis Allergy (IF 12.6) Pub Date : 2025-01-30 Andreas Boldt, Regina Treudler, Marie Rabe, Niklas Artz, Sabine Seiffert, Rachael Bogle, Xianying Xing, Louise Wilkens, Ariane Bialas, Lea Präger, Lam C. Tsoi, Ulrike Koehl, Sandra Franz, Sonja Grunewald, Jan C. Simon, J. Michelle Kahlenberg, Johann E. Gudjonsson, Benjamin Klein
-
Why Anti–IL‐17 Therapy Fails: The Role of Autonomous IL‐17R Signaling in Autoimmune Inflammation Allergy (IF 12.6) Pub Date : 2025-01-29 Fabio S. Ryser, Joseena Iype, Lisa Christ
-
The Complex Nomenclature of Allergic Diseases and Hypersensitivity Reactions: An Addendum to the EAACI Position Paper Allergy (IF 12.6) Pub Date : 2025-01-28 Andrea Szegedi, Zsolt I. Komlósi, Anikó Kapitány, Zsuzsanna Bata‐Csörgő, Gábor Koncz, Attila Bácsi
-
Prevalence of Mental Health Symptoms in Chronic Urticaria: A Systematic Review and Meta‐Analysis Allergy (IF 12.6) Pub Date : 2025-01-28 Daniel G. Rayner, David Gou, Laura Weiler, Lola Irelewuyi, Grace Xiong, Elaine Wang, Tresha Sivanesanathan
-
EAACI Clinical and Research Fellowship Program: Shaping the Future of Allergy and Clinical Immunology Allergy (IF 12.6) Pub Date : 2025-01-27 Ruben Fernandez Santamaria, Aspasia Karavelia, Mattia Giovannini, Leticia De Las Vecillas, Patrizia Bonadonna, Stefano Del Giacco, Oliver Pfaar, Jolanta Walusiak Skorupa, Andre Moreira, Maria Jose Torres, Mohamed Shamji, Oscar Palomares
-
MHC Class II‐Expressing Mucosal Mast Cells Promote Intestinal Mast Cell Hyperplasia in a Mouse Model of Food Allergy Allergy (IF 12.6) Pub Date : 2025-01-27 Kenji Oishi, Nobuhiro Nakano, Masamu Ota, Eisuke Inage, Kumi Izawa, Ayako Kaitani, Tomoaki Ando, Mutsuko Hara, Yoshikazu Ohtsuka, Chiharu Nishiyama, Hideoki Ogawa, Jiro Kitaura, Ko Okumura, Toshiaki Shimizu
BackgroundIgE‐mediated food allergy is accompanied by mucosal mast cell (MMC) hyperplasia in the intestinal mucosa. Intestinal MMC numbers correlate with the severity of food allergy symptoms. However, the mechanisms by which MMCs proliferate excessively are poorly understood. Here, we clarify the role of newly identified MHC class II (MHCII)‐expressing MMCs in the effector phase of IgE‐mediated food
-
GWAS Identifies CACNA2D3 Associated With Asthma and Atopic Dermatitis Multimorbidity in Children Allergy (IF 12.6) Pub Date : 2025-01-27 Dong Yun Kim, Soyeon Lee, Jae Hwa Jung, Yujin Sub, Sumin Lee, Eun Gyul Kim, Mi Na Kim, Soo Yeon Kim, Yoon Hee Kim, Myung Hyun Sohn, Heon Yung Gee, Kyung Won Kim
-
Association Between Long‐Term Exposure to Ambient Air Pollution and the Risk of Recurrent Asthma Hospitalizations Allergy (IF 12.6) Pub Date : 2025-01-24 Jin‐Lun Zhang, Chong‐Ye Zhao, Xiao‐Han Xu, Chen Shi, Hao‐Neng Huang, Yi‐Ming Tao, Li Li, Chun‐Quan Ou
-
A Silver (Birch) Bullet for Children With Tree Pollen Allergy: Single Allergen Immunotherapy With Birch Extract Protects Across the Birch Homologous Group Pollen Season Allergy (IF 12.6) Pub Date : 2025-01-23 Eve Denton, Mark Hew, Robyn E. O'Hehir
-
Recombinant IgE‐Reactive Functional Can f 5 Devoid of Cross‐Reactive Carbohydrate Determinants Allergy (IF 12.6) Pub Date : 2025-01-21 Evgenii Kozlov, Daria Trifonova, Alexandra Dubovets, Anastasia Usanova, Inna Tulaeva, Pia Gattinger, Daria Fomina, Wolfgang Hemmer, Neonila Gorokhovets, Rudolf Valenta, Alexander Karaulov
-
Roles of Interleukin‐24 in Epithelial Repair: Bridging Injury and Regeneration Allergy (IF 12.6) Pub Date : 2025-01-21 Morgan Bryant, Piotr P. Janas, Thibaut Sanchez
-
Effectiveness and Safety of Dupilumab for Prurigo Nodularis in China: A Multicentric and Observational Study Allergy (IF 12.6) Pub Date : 2025-01-21 Zuotao Zhao, Xiaoting Song, Yuanyuan Shang, Lijuan Liu, Rui Zheng, Jianxin Xia, Qiang Liu, Guodong Hao, Jie Li, Songmei Geng, Jingang An, Qiang Wang, Xiaoyan Liu, Jianping Tang, Yizhu Xiao, Litao Zhang
BackgroundThe efficacy and safety of dupilumab in patients with refractory prurigo nodularis (PN) is well established in clinical trials, but there is a lack of multicenter data regarding its effectiveness and safety in real‐world settings.MethodsPatients with moderate‐to‐severe PN who initiated dupilumab treatment between July 2023 and January 2024, with a follow‐up period of at least 16 weeks at
-
IL‐25 Enhances B Cell Responses in Type 2 Inflammation Through IL‐17RB Receptor Allergy (IF 12.6) Pub Date : 2025-01-20 Semah Abdu, Jiao Xia, Huihui Yuan, Tiak Ju Tan, Janice A. Layhadi, Mohamed H. Shamji, Andrew N. J. McKenzie, Nora Haloob, Claire Hopkins, Grzegorz Woszczek, Stephen J. Till
BackgroundAlarmin cytokine IL‐25 promotes type 2 inflammatory responses in disorders such as asthma and chronic rhinosinusitis with nasal polyps (CRSwNP) and known targets include ILC2 and Th2 cells. However, other cellular targets for IL‐25 remain poorly defined.ObjectiveTo investigate induction and expression of IL‐25 receptor (IL‐17RB) by B cells and evaluate responsiveness of IL‐17RB‐expressing
-
Stratum Corneum Interleukin‐2 in Facial Eczema at 1‐Month‐Old Predicts Later Atopic Dermatitis Allergy (IF 12.6) Pub Date : 2025-01-15 Eriko Maehara, Makiko Kido‐Nakahara, Yasuyuki Fujita, Kiyoko Kato, Saki Kido, Ryo Yamasaki, Satoshi Nagata, Junji Kishimoto, Hiroko Watanabe, Eri Harada, Yumiko Nagashima, Eisuke Umeno, Gaku Tsuji, Hitokazu Esaki, Takeshi Nakahara
-
Allergic Reactivity and Memory Occur Independently of Sequential Switching Through IgG1 Allergy (IF 12.6) Pub Date : 2025-01-13 Joshua F. E. Koenig, Adam K. Wade‐Vallance, Rodrigo Jiménez‐Saiz, Kelly Bruton, Siyon Gadkar, Emily Grydziuszko, Tina D. Walker, Melissa E. Gordon, Amy E. Gillgrass, Justin J. Taylor, Susan Waserman, Manel Jordana
Allergic reactions to foods are primarily driven by allergen‐binding immunoglobulin (Ig)E antibodies. IgE‐expressing cells can be generated through direct switching from IgM to IgE or a sequential class switching pathway where activated B cells first switch to an intermediary isotype, most frequently IgG1, and then to IgE. It has been proposed that sequential class switch recombination is involved
-
Evaluation of Intestinal Permeability Using Serum Biomarkers in Learning Early About Peanut Allergy Trial Allergy (IF 12.6) Pub Date : 2025-01-13 Ozge Nur Aktas, Allyson Mateja, Min (Jenny) Li, Lindsay Chatman, Megan C. Grieco, Carolyn H. Baloh, Michelle Huffaker, Lisa M. Wheatley, George du Toit, Gideon Lack, Erica Brittain, Pamela A. Frischmeyer‐Guerrerio
BackgroundIntestinal barrier dysfunction may lead to a break in tolerance and development of food allergy (FA). There is contradictory evidence on whether intestinal permeability (IP) is altered in IgE‐mediated FA. Thus, we sought to determine whether IP differed between children with eczema who did (FA group) or did not (atopic controls, ACs) develop FA and whether peanut sensitization, allergy, and
-
-
Early Puberty and Risk of Asthma: Meta‐Analysis and Systematic Review Allergy (IF 12.6) Pub Date : 2025-01-11 Fu‐Min Chang, Yung‐Feng Lin, Hsiao‐Chi Chuang, Jhih‐Wei Hsu, Yang‐Ching Chen
-
Type 2 IgG Memory B Cells as Precursors of IgE Plasma Cells Allergy (IF 12.6) Pub Date : 2025-01-11 Larissa Nogueira de Almeida, Janina Petry, Christopher C. Udoye
-
Early‐Life Diet and Persistent Atopic Dermatitis: A Nationwide Cohort Study Allergy (IF 12.6) Pub Date : 2025-01-10 Ji Su Lee, Seong Rae Kim, Dong Hyo Kim, Soo Ick Cho, Dong Hun Lee
-
CT‐P39 Compared With Reference Omalizumab in Chronic Spontaneous Urticaria: Results From a Double‐Blind, Randomized, Active‐Controlled, Phase 3 Study Allergy (IF 12.6) Pub Date : 2025-01-09 Sarbjit S. Saini, Marcus Maurer, Yevgeniya Dytyatkovska, Ewa Springer, Maria Ratkova, Borislava Krusheva, Chun Wook Park, Grazyna Pulka, Marta Chełmińska, Adam Reich, Sunghyun Kim, Keumyoung Ahn, Suyoung Kim, Sewon Lee, Jieun Ka, Jongho Kim, Clive Grattan
BackgroundThis study compared the therapeutic equivalence of CT‐P39 (an omalizumab biosimilar) and EU‐approved reference omalizumab (ref‐OMA) in patients with chronic spontaneous urticaria.MethodsThis double‐blind, randomized, active‐controlled Phase 3 study (NCT04426890) included two 12‐week treatment periods (TPs). In TP1, patients received CT‐P39 300 mg, ref‐OMA 300 mg, CT‐P39 150 mg, or ref‐OMA
-
Algorithms in Allergy: Organ‐Specific Allergen Challenges for the Phenotyping of Chronic Respiratory Diseases Allergy (IF 12.6) Pub Date : 2025-01-08 Dulce Sanchez‐Torralvo, Almudena Testera‐Montes, Guillermo Bentabol‐Ramos, Ibon Eguiluz‐Gracia, Ralph Mösges, Maria J. Torres
-
Comorbid Bronchial Asthma, Atopic Dermatitis and Hashimoto's Thyroiditis Are Risk Factors for Early‐Onset, Severe and Prolonged Alopecia Areata Allergy (IF 12.6) Pub Date : 2025-01-08 Annika Friedrich, Marie‐Therese Schmitz, Yasmina Gossmann, Silke Redler, Bettina Blaumeiser, Gerhard Lutz, Ulrike Blume‐Peytavi, Markus M. Nöthen, Regina C. Betz, F. Buket Basmanav
-
Real‐World Impact of COVID‐19 on Subcutaneous Immunotherapy Persistence and Efficacy in Allergic Rhinitis Allergy (IF 12.6) Pub Date : 2025-01-06 Xuan Yuan, Liyuan Liu, Benjian Zhang, Shaobing Xie, Lai Meng, Wei Zhong, Jiaxin Jia, Hua Zhang, Weihong Jiang, Zhihai Xie
-
Skin Tape Stripping Reveals Distinct Biomarker Profiles in Chronic Hand Eczema of Patients With and Without Comorbid Atopic Dermatitis Allergy (IF 12.6) Pub Date : 2025-01-06 Jonathan Bar, Ester Del Duca, Eden David, Swaroop Bose, Gabriella Chefitz, Patrick M. Brunner, Robert Bissonnette, Emma Guttman‐Yassky
IntroductionChronic hand eczema (CHE) is a highly prevalent inflammatory skin condition which is often resistant to conventional treatments. Molecular insights of CHE remain limited. Tape stripping combined with high‐throughput RNA sequencing can now provide a better insight into CHE pathogenesis in a minimally invasive fashion.MethodsWe collected tape strip samples from lesional and non‐lesional skin
-
Hypereosinophilia and Hypereosinophilic Syndromes: First Findings From a Nationwide Multicenter Cohort. Allergy (IF 12.6) Pub Date : 2025-01-05 Guillaume Lefèvre,Séverine Bleuse,Mathieu Puyade,Guillaume Moulis,Antoine Néel,Noémie Abisror,Antoine Baudet,Bernard Bonnotte,Jérémie Dion,Antoine Dossier,Maximilien Grall,François Lifermann,Nicolas Limal,Bertrand Lioger,Irène Machelart,Catherine Mohr,Roderau Outh,Viviane Queyrel-Moranne,Borhane Slama,Ludovic Tréfond,Wadih Abou Chahla,Félix Ackerman,Nabil Belfeki,Alice Berezne,Jean-Sébastien Blade
BACKGROUND Hypereosinophilic syndromes (HES) are a heterogenous group of eosinophilic disorders. To date, only retrospective studies of limited sample-size and/or follow-up duration are available. METHODS The COHESion study is a national prospective multicenter multidisciplinary cohort recruiting both adults or children with the spectrum of eosinophilic disorders (including reactive HE/HES [HE/HES-R]
-
Organic Food Consumption Might Protect Against Sensitisation to Inhalant Allergens at School Age: The PARIS Cohort Allergy (IF 12.6) Pub Date : 2025-01-03 Maëlys Pernin‐Schneider, Hélène Amazouz, Guillaume Lezmi, Mélisande Bourgoin‐Heck, Jocelyne Just, Isabelle Momas, Fanny Rancière
BackgroundInterest has grown recently in childhood diet's role in allergy development. However, the studies focusing on organic food consumption are scarce. We address the relationships between such consumption and respiratory/allergic morbidity at school age in the PARIS (Pollution and asthma risk: An infant study) cohort.MethodsDiet was assessed using a food frequency questionnaire completed by the
-
The Role of WNT5a and TGF‐β1 in Airway Remodelling and Severe Asthma Allergy (IF 12.6) Pub Date : 2025-01-03 Tariq Daud, Sheree Roberts, Nazanin Zounemat Kermani, Matthew Richardson, Liam G. Heaney, Ian M. Adcock, Yassine Amrani, Peter Bradding, Salman Siddiqui
BackgroundAirway remodelling is a feature of severe asthma with airway epithelial damage observed frequently. We evaluated the role of WNT5a and TGF‐β1 in asthmatic airway biopsies and in sputum and bronchial brushings assessed their role in remodelling.MethodsWNT5a and TGF‐β1 protein expression were assessed in the lamina propria epithelium of people with asthma (GINA 1–3, n‐8 and GINA 4–5, n‐14)
-
BLOC1S1 Control of Vacuolar Organelle Fidelity Modulates Murine TH2 Cell Immunity and Allergy Susceptibility Allergy (IF 12.6) Pub Date : 2024-12-31 Rahul Sharma, Kaiyuan Wu, Kim Han, Anna Chiara Russo, Pradeep K. Dagur, Christian A. Combs, Xianglan Yao, Stewart J. Levine, Michael N. Sack
BackgroundThe levels of biogenesis of lysosome organelles complex 1 subunit 1 (BLOC1S1) control mitochondrial and endolysosome organelle homeostasis and function. Reduced fidelity of these vacuolar organelles is increasingly being recognized as important in instigating cell‐autonomous immune cell activation. We reasoned that exploring the role of BLOC1S1 in CD4+ T cells may further advance our understanding
-
What Is the Next Step for Patients With Aspirin‐Exacerbated Respiratory Disease: Biologics With or Without Aspirin Therapy? Allergy (IF 12.6) Pub Date : 2024-12-31 Piotr Szatkowski, Lucyna Mastalerz
-
Soybean Oil in Propofol Is Not Able to Induce Allergic Reactions Allergy (IF 12.6) Pub Date : 2024-12-30 Deniz Eyice Karabacak, Lisa Arzt‐Gradwohl, Barbara Binder, Eva Schadelbauer, Christina Vallant, Karin Laipold, Gunter J. Sturm
-
-
Exhaled Nitric Oxide and Sputum Eosinophils Are Complementary Tools for Diagnosing Occupational Asthma. Allergy (IF 12.6) Pub Date : 2024-12-27 Virginie Doyen,Nicolas Migueres,Vera van Kampen,Hille Suojalehto,Paola Mason,Xavier Munoz,Joaquin Sastre,Santiago Quirce,Cecilie Svanes,Gareth Walters,Vicky Moore,Iben Brock Jacobsen,Ilenia Folletti,Alexandra M Preiser,Jolanta Walusiak-Skorupa,Catherine Rifflart,Frédéric de Blay,Olivier Vandenplas,
BACKGROUND Exposure-related changes in exhaled nitric oxide (FeNO) and sputum eosinophils have not been thoroughly compared in the investigation of occupational asthma. OBJECTIVE This study aimed at comparing the accuracies of the changes in FeNO concentrations and sputum eosinophil counts in identifying asthmatic reactions induced by occupational agents during specific inhalation challenges (SICs)
-
The Relationship Between Dietary Patterns and the Epidemiology of Food Allergy Allergy (IF 12.6) Pub Date : 2024-12-26 Agnes Sze‐Yin Leung, Yuhan Xing, Montserrat Fernández‐Rivas, Gary Wing‐Kin Wong
Food allergies are increasing globally, particularly in Asia; however, the etiologies of allergic diseases remain poorly understood despite comprehensive studies conducted across a variety of populations. Epidemiological research demonstrates that food allergy is more prevalent in Westernized or urbanized societies than in rural or developing ones. As such, comparing the distribution and patterns of
-
Genotype‐Guided Asthma Treatment Reduces Exacerbations in Children: Meta‐Analysis of Two RCTs Allergy (IF 12.6) Pub Date : 2024-12-26 Elise M. A. Slob, Susanne J. H. Vijverberg, Tom Ruffles, Lieke C. E. Noij, Jacqueline Biermann, Alwin F. J. Brouwer, Kristel van den Brink, Annette de Bruin‐Kok, Bart E. Van Ewijk, Eric Haarman, Sanne C. Hammer, Simone Hashimoto, Fiona Hogarth, Christina J. Jones, Arvid W. A. Kamps, Elin T. G. Kersten, Ismé de Kleer, Brian J. Lipworth, Roberta Littleford, Marieke Mérelle, Alexander Moeller, Colin N
BackgroundLong‐acting beta2‐agonists (LABA) in combination with inhaled corticosteroids (ICS) are commonly used to treat asthma, however, some children lack response to the addition of LABA. This might be partially due to the presence of the Arg16Gly polymorphism, encoded by rs1042713 G>A in the ADRB2 gene. Carrying the A allele (Arg16) at this variant has been associated with an increased risk of
-
Maternal Allergic Disease Phenotype and Infant Birth Season Influence the Human Milk Microbiome Allergy (IF 12.6) Pub Date : 2024-12-26 Jie Ma, Debra J. Palmer, Donna Geddes, Ching Tat Lai, Alethea Rea, Susan L. Prescott, Nina D'Vaz, Lisa F. Stinson
Early infancy is a critical period for immune development. In addition to being the primary food source during early infancy, human milk also provides multiple bioactive components that shape the infant gut microbiome and immune system and provides a constant source of exposure to maternal microbiota. Given the potential interplay between allergic diseases and the human microbiome, this study aimed
-
Allergen Specific IgE is a Stronger Predictor of Remission Following Peanut Oral Immunotherapy Than Age in Children Aged 1–10 Years Allergy (IF 12.6) Pub Date : 2024-12-26 Sarah E. Ashley, Melanie Lloyd, Paxton Loke, Francesca Orsini, Adriana C. Lozinsky, Michael D. O'Sullivan, Patrick Quinn, Michael Gold, Mimi L. K. Tang
BackgroundRemission is the desired outcome following OIT as it allows individuals to discontinue treatment and eat the allergen freely. Early initiation of OIT in infants and toddlers has been embraced as an approach to increase the likelihood of remission. However, there is no high‐quality evidence supporting younger age as an independent factor driving remission; available studies are limited by
-
Assessing Risk Factors for Relapse Following Omalizumab Discontinuation in Chronic Urticaria Allergy (IF 12.6) Pub Date : 2024-12-26 Melek Cihanbeylerden, João Teixeira, Hazal Kayıkçı, Çise Tüccar, Ali Fuat Kalyoncu, Ebru Damadoglu, Margarida Gonçalo, Gül Karakaya
-
Identification of Gut Biomarkers of FPIES in a Longitudinal Comparative Pediatric Study Allergy (IF 12.6) Pub Date : 2024-12-26 A. Lemoine, N. Kapel, I. Nicolis, P. Tounian, A. Bruneau, N. Kapandji, K. Adel‐Patient, M. Thomas
BackgroundFood protein‐induced enterocolitis syndrome (FPIES) is a non‐IgE‐mediated allergy without known biomarkers. We aimed to compare fecal biomarkers related to gut inflammation and immunity in children with FPIES, with resolved FPIES (tolerant), and in matched controls.MethodsStools were collected from FPIES children on elimination diet, before and after an oral food challenge (OFC) performed
-
Exposure Profiles for the Long‐Term Use of Disinfectants and Cleaning Products and Asthma Allergy (IF 12.6) Pub Date : 2024-12-26 Emilie Pacheco Da Silva, Tobias Weinmann, Jessica Gerlich, Gudrun Weinmayr, Jon Genuneit, Dennis Nowak, Erika von Mutius, Christian Vogelberg, Katja Radon, Felix Forster
BackgroundUsing disinfectants and cleaning products (DCPs) at home and work is known to influence both the onset and course of asthma, but most epidemiological studies did not consider the multiplicity and correlations of exposures to DCPs. We aimed to identify exposure profiles for the long‐term weekly use of DCPs by latent class analysis (LCA) and assess their associations with asthma.MethodsLCA
-
Transcriptomic Profiles of the Nasal Mucosa Following Birch Pollen Provocation Differ Between Birch Pollen‐Allergic and Non‐Allergic Individuals Allergy (IF 12.6) Pub Date : 2024-12-24 Srinidhi Sudharson, Julia Eckl‐Dorna, Anastasia Meshcheryakova, José Basílio, Sophia Derdak, Tanja Kalic, Nina Lengger, Nina Schweitzer, Diana Mechtcheriakova, Heimo Breiteneder, Christine Hafner
BackgroundBirch pollen (BP) interacts with airway epithelial cells to cause allergic sensitization and allergy in predisposed individuals. However, the basic mechanisms underlying the clinical effects are poorly understood. Changes in gene expression and cytokine secretion in nasal mucosal cells upon BP exposure were determined in BP‐allergic and non‐allergic individuals.MethodsBP‐allergic (n = 11)
-
A Differentiated Epithelial Layer Graft Improves Fibrosis and Survival in Airway Stenosis via IL‐37 Allergy (IF 12.6) Pub Date : 2024-12-23 Roza Khalmuratova, Yi Sook Kim, Dae Woo Kim, Hyun‐Woo Shin
-
Allergen‐Specific B Cell Responses Following Desensitisation and Natural Tolerance to Cow's Milk Allergy Allergy (IF 12.6) Pub Date : 2024-12-23 Mohamed H. Shamji, Edwin H. Kim, Marta Vazquez‐Ortiz, Paul J. Turner, Janice A. Layhadi
-
Salivary Metabolomic Signatures in Pediatric Eosinophilic Esophagitis Allergy (IF 12.6) Pub Date : 2024-12-21 Girish Hiremath, Simona G. Codreanu, Stacy D. Sherrod, Regina Tyree, Hernan Correa, Yash Choksi, John A. McLean, Andrea Locke
-
Oncostatin‐M Is Produced by Human Eosinophils and Expression Is Increased in Uncontrolled Severe Asthma Allergy (IF 12.6) Pub Date : 2024-12-21 Stephane Esnault, Ksenija Bernau, Heather L. Floerke, Arnaud Dendooven, Emeline Delaunay, Kimberly A. Dill‐McFarland, Matthew C. Altman, William W. Busse, Melissa A. Rosenkranz, Matthew C. Tattersall, Mats W. Johansson, Julien Labreuche, Delphine Beury, Shéhérazade Sebda, Frédéric Dezoteux, Baptiste Segard, Geoffrey Mortuaire, Delphine Staumont‐Sallé, Thomas Stoup, Cécile Chenivesse, Nathan Sandbo