Background Psoriasis confers elevated risk of coronary-artery disease. Objective Do patients with severe psoriasis have larger epicardial adipose tissue volumes (EAT-V) that are associated with cardiovascular risk? Methods For this cross-sectional study, we recruited dermatology patients with severe psoriasis and control patients without psoriasis or rheumatologic disease themselves or in a first-degree

Background Cutaneous squamous cell carcinoma (cSCC) represents the most serious form of keratinocyte cancers due to its metastatic potential. Studies on nationwide incidence and disease-specific survival rates of metastatic cSCC (mcSCC) are lacking. Objective To investigate the cumulative incidence and disease-specific survival of mcSCC patients in the Dutch population and assess patient-based risk

Dermatologists diagnose and treat many immune-mediated inflammatory diseases (IMID). Understanding the inherent immune dysregulation of these diseases as well as the additional disruption that comes as a result of IMID treatments has been important during the COVID-19 pandemic. With vaccines becoming widely available, dermatologists need to be familiar with the risks and benefits of vaccination in

Itch pathogenesis is broadly characterized into histaminergic and nonhistaminergic pathways and transmitted via two main receptor families – G-protein coupled receptors and transient receptor potential channels. In the skin, itch is primarily transmitted by unmyelinated type C and thinly myelinated type Aδ nerve fibers. Crosstalk between the immune and neural systems modulates itch transmission at

Background Clinical trials report occurrence of non-melanoma skin cancers (NMSC) with ruxolitinib in polycythemia (PV) or myelofibrosis (MF) patients, however the level of risk and effect of covariates are not known in the real-world setting. Objective To systematically assess the risk of developing non-melanoma skin cancer (NMSC) after ruxolitinib exposure in PV or MF patients. Methods A 10-year retrospective

Background Accurate diagnosis of epidermolysis bullosa (EB) has significant implications for prognosis, management, and genetic counseling. Objective To describe diagnostic testing patterns and assess diagnostic concordance of transmission electron microscopy (TEM), immunofluorescence mapping (IFM), and genetic analysis for EB. Methods A retrospective cohort of patients enrolled in the Epidermolysis

Background There is limited literature regarding potential disparities in nonmelanoma skin cancer for patients with skin of color. Objective Use the sizes of Mohs micrographic surgery defects to examine disparities in nonmelanoma skin cancer among Hispanic/Latino patients with a secondary aim to examine the effect of insurance type. Methods We conducted a multicenter retrospective study using data

Background Psoriasis affects 0.13–2.1% of children and adolescents. Despite high unmet need, the current treatment options approved for pediatric psoriasis are limited. Objective Evaluate the efficacy and safety of two secukinumab dosage regimens (low dose: 75/75/150 mg and high dose: 75/150/300 mg) stratified and randomized by weight (<25kg, 25–<50kg, ≥50kg) and disease severity (moderate, severe)

Background Mohs micrographic surgery or wide local excision is the treatment of choice for fibrohistiocytic tumors with metastatic potential, including atypical fibroxanthoma (AFX) and cutaneous undifferentiated pleomorphic sarcoma (cUPS). Since margin clearance is the strongest predictor of clinical recurrence, improved recommendations for appropriate surgical margins help delineate uniform excision

Antibiotic resistance is a growing health concern that has attracted increasing attention from clinicians and scientists in recent years. While resistance is an inevitable consequence of bacterial evolution and natural selection, misuse and overuse of antibiotics plays a significant role in its acceleration. Antibiotics are the mainstay of therapy for common dermatoses, including acne and rosacea,

Background Lower socioeconomic position usually portends worse health outcomes, but multiple studies have found that atopic dermatitis is associated with higher socioeconomic position, but the nature of this relationship remains unclear. Objective To systematically review the literature on socioeconomic position and atopic dermatitis and determine if the association varies by patient or study characteristics

Background Limited data exist on the incidence and prevalence of psoriatic arthritis (PsA) among US patients with psoriasis (PsO) based on disease severity. Objective To assess the incidence, prevalence, and predictors of PsA among patients with PsO stratified by PsO severity using treatment type. Methods From the Optum electronic health records database, incidence of PsA per 100 PsO patient-years