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A Recurrent Orbital Hemorrhage in an Older Adult. JAMA Ophthalmol. (IF 8.253) Pub Date : 2022-08-11 Alexis Mathieu,Romain Nicot,Matthias Schlund
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Severe Familial Exudative Vitreoretinopathy, Congenital Hearing Loss, and Developmental Delay in a Child With Biallelic Variants in FZD4. JAMA Ophthalmol. (IF 8.253) Pub Date : 2022-08-11 Sarah R van der Ende,Benjamin S Meyers,Jenina E Capasso,Mario Sasongko,Yoshihiro Yonekawa,Matthew Pihlblad,Jennifer Huey,Emma C Bedoukian,Ian D Krantz,Michael H Ngo,Christopher R McMaster,Alex V Levin,Johane M Robitaille
Importance Familial exudative vitreoretinopathy (FEVR) is a nonsyndromic autosomal dominant retinal disorder commonly caused by variants in the FZD4 gene. This study investigates the potential role beyond ocular abnormalities for FZD4 gene variants in patients with FEVR. Objective To evaluate the role of FZD4 in symptoms beyond those associated with FEVR through a patient with biallelic variants in
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COVID-19 Vaccination Rates Among US Adults With Vision or Hearing Disabilities. JAMA Ophthalmol. (IF 8.253) Pub Date : 2022-08-11 Kea Turner,Oliver T Nguyen,Amir Alishahi Tabriz,Jessica Y Islam,Young-Rock Hong
Importance Despite persistent care delivery inequities, limited studies have assessed COVID-19 vaccination rates among adults with vision or hearing disabilities. Objective To estimate the prevalence of and factors in COVID-19 vaccination among US adults with vision or hearing disabilities. Design, Setting, and Participants This cross-sectional study assessed data from adults who participated in the
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Numerous White Retinal Lesions Following Cataract Surgery. JAMA Ophthalmol. (IF 8.253) Pub Date : 2022-08-04 Kurt Scavelli,William B Priester,Avni P Finn
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Effect of Modified Vertical Rectus Belly Transposition vs Augmented Superior Rectus Transposition Plus Medial Rectus Recession for Chronic Sixth Nerve Palsy: A Randomized Clinical Trial. JAMA Ophthalmol. (IF 8.253) Pub Date : 2022-08-04 Jing Yao,Chao Jiang,Xiying Wang,Weiyi Xia,Ling Ling,Wenqing Zhu,Lianqun Wu,Chen Zhao
Importance Both vertical rectus belly transposition (VRBT) and superior rectus transposition (SRT) can be performed simultaneously with ipsilateral medial rectus recession (MRc) and have been shown to be effective for chronic sixth nerve palsy. However, it is unclear whether VRBT is superior to SRT in correcting esotropia. Objective To compare the effectiveness of modified VRBT plus MRc (mVRBT-MRc)
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Plasma Levels of Vascular Endothelial Growth Factor After Low-Dose Bevacizumab Treatment for Retinopathy of Prematurity Study-More Questions Than Answers. JAMA Ophthalmol. (IF 8.253) Pub Date : 2022-08-04 Talkad S Raghuveer,Stephanie Binder
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A Pruritic Eyelid Lesion Followed by Conjunctival Swelling. JAMA Ophthalmol. (IF 8.253) Pub Date : 2022-08-04 Eun Young Choi,Alan D Proia,Kyle Kirkland
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Characteristics of Semiautomated Endothelial Cell-Density Measurements Among Corneal Donor Eyes. JAMA Ophthalmol. (IF 8.253) Pub Date : 2022-07-28 Wuqaas M Munir,Saleha Z Munir
Importance Endothelial cell density in corneal donor eyes remains a critical component in selecting tissue suitable for corneal transplant. Objective To describe an anomaly in endothelial cell density discovered in a large cohort of corneal donor eyes. Design, Setting, and Participants Donor information for this cross-sectional study was obtained from the CorneaGen eye bank for donors from June 1,
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Questions Regarding the 2019 Quality Payment Program Performance for Ophthalmologists. JAMA Ophthalmol. (IF 8.253) Pub Date : 2022-07-28 Flora Lum,David Glasser,Cathy G Cohen
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Questions Regarding the 2019 Quality Payment Program Performance for Ophthalmologists-Reply. JAMA Ophthalmol. (IF 8.253) Pub Date : 2022-07-28 Sean T Berkowitz,Shriji Patel
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Association Between Open Payments-Reported Industry Transfers of Value and Prostaglandin Analog Prescribing in the US. JAMA Ophthalmol. (IF 8.253) Pub Date : 2022-07-28 Andrew M Nguyen,Kelly E Anderson,Gerard Anderson,Thomas V Johnson
Importance Reported transfers of value (TOV) from pharmaceutical companies have been associated with greater use of branded anti-vascular endothelial growth factor agents by ophthalmologists, but payment under the Medicare Part B buy-and-bill model includes a financial incentive to choose costlier agents, potentially confounding analyses of pharmaceutical TOV and prescribing patterns. How these reported
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Association Between Myopic Refractive Error and Primary Open-Angle Glaucoma: A 2-Sample Mendelian Randomization Study. JAMA Ophthalmol. (IF 8.253) Pub Date : 2022-07-28 Hélène Choquet,Anthony P Khawaja,Chen Jiang,Jie Yin,Ronald B Melles,M Maria Glymour,Pirro G Hysi,Eric Jorgenson
Importance Refractive error (RE) is the most common form of visual impairment, and myopic RE is associated with an increased risk of primary open-angle glaucoma (POAG). Whether this association represents a causal role of RE in the etiology of POAG remains unknown. Objective To evaluate shared genetic influences and investigate the association of myopic RE with the risk for POAG. Design, Setting, and
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Adult Female Patient with Giant Periorbital Hidrocystomas. JAMA Ophthalmol. (IF 8.253) Pub Date : 2022-07-21 Rona Z Silkiss,Sarah E Eppley
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Congenital Lamellar and Sutural Cataract in a Patient With Type 2 Diabetes. JAMA Ophthalmol. (IF 8.253) Pub Date : 2022-07-21 Rupin N Parikh,Carolyn E Kloek
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Pseudorheumatoid Nodules of the Eyelid in a Boy Aged 4 Years. JAMA Ophthalmol. (IF 8.253) Pub Date : 2022-07-21 Samantha M Arsenault,Katherine Williams,Richard C Allen
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Retinopathy in Presumed Congenital Rubella Syndrome. JAMA Ophthalmol. (IF 8.253) Pub Date : 2022-07-21 Minsoo Kim,Amir H Kashani
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Globe and Adnexal Trauma Terminology Survey. JAMA Ophthalmol. (IF 8.253) Pub Date : 2022-07-21 Annette K Hoskin,Michael J Fliotsos,Andrés Rousselot,Sean Ming Sheng Ng,Grant A Justin,Richard Blanch,Marcus H Colyer,Bhartendu Shukla,Sundaram Natarajan,Ferenc Kuhn,Gangadhara Sundar,Fasika A Woreta,Stephanie L Watson,Rupesh Agrawal,
Importance Ocular trauma terminology should be periodically updated to enable comprehensive capturing and monitoring of ocular trauma in clinical and research settings. Objective To update terminology for globe and adnexal trauma. Design, Setting, and Participants A 2-round modified Delphi survey was conducted from January 1 to July 31, 2021, using an expert panel, including 69 ophthalmologists identified
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A Young Boy With Changes in the Retinal Pigment Epithelium. JAMA Ophthalmol. (IF 8.253) Pub Date : 2022-07-21 Ashley Lopez-Cañizares,Piero Carletti,Audina M Berrocal
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In Defense of Phosphodiesterase 5 Inhibitors. JAMA Ophthalmol. (IF 8.253) Pub Date : 2022-07-21 Federico Belladelli,Francesco Del Giudice,Michael L Eisenberg
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A Modified Trocar and Cannula System With Lateral Micropores for 1-Step Drainage of Suprachoroidal Fluid During Primary Vitrectomy. JAMA Ophthalmol. (IF 8.253) Pub Date : 2022-07-21 Wen-Wen Zhang,Feng Jiang,Zheng-Gao Xie
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In Defense of Phosphodiesterase 5 Inhibitors-Reply. JAMA Ophthalmol. (IF 8.253) Pub Date : 2022-07-21 Mohit Sodhi,Frederick S Mikelberg,Mahyar Etminan
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Predicted vs Observed Metastasis-Free Survival in Individuals With Uveal Melanoma. JAMA Ophthalmol. (IF 8.253) Pub Date : 2022-07-21 Arun D Singh,Elaine M Binkley,Jacquelyn M Wrenn,James F Bena,Connie Hinz,H Culver Boldt
Importance Accuracy of the predicted metastasis-free survival (MFS) by a commercially available gene expression profiling (GEP) test is not known. Objective To compare the predicted MFS with the observed MFS in patients in this cohort and with those in published studies (published MFS, meta-analysis). Design, Setting, and Participants This cohort study included consecutive patients from the University
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Association of Optical Coherence Tomography and Optical Coherence Tomography Angiography Retinal Features With Visual Function in Older Adults. JAMA Ophthalmol. (IF 8.253) Pub Date : 2022-07-14 Yanan Dong,Xinxing Guo,Lubaina T Arsiwala-Scheppach,A Richey Sharrett,Pradeep Y Ramulu,Aleksandra Mihailovic,Nathan Pan-Doh,Thomas Mosley,Josef Coresh,Alison G Abraham
Importance Although there is abundant evidence relating neuronal and vascular optical coherence tomography (OCT) and OCT angiography (OCTA) measures to retinal disease, data on the normative distribution of retinal features and their associations with visual function in a healthy, older, community-based population are sparse. Objectives To characterize the normative OCT and OCTA measures in older adults
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A White Retinal Lesion With Calcification in an 11-Year-Old Boy. JAMA Ophthalmol. (IF 8.253) Pub Date : 2022-07-14 Leonardo Lando,Ashwin Mallipatna,Brenda Gallie
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Promises and Pitfalls of Retinal Biomarkers in Systemic Health and Disease. JAMA Ophthalmol. (IF 8.253) Pub Date : 2022-07-14 Amir H Kashani
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Ranibizumab Injection (Susvimo) Implant Septum Dislodgement in a Patient With Neovascular Age-Related Macular Degeneration. JAMA Ophthalmol. (IF 8.253) Pub Date : 2022-07-14 Kaitlyn Timmons,Luke C Heckmann,Yong Ren,Ivana Gunderson,Fuad Makkouk,Brian B Berger
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The Pursuit of Generalizability and Equity Through Artificial Intelligence-Based Risk Prediction Models. JAMA Ophthalmol. (IF 8.253) Pub Date : 2022-07-07 Isdin Oke
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External Validation of a Retinopathy of Prematurity Screening Model Using Artificial Intelligence in 3 Low- and Middle-Income Populations. JAMA Ophthalmol. (IF 8.253) Pub Date : 2022-07-07 Aaron S Coyner,Minn A Oh,Parag K Shah,Praveer Singh,Susan Ostmo,Nita G Valikodath,Emily Cole,Tala Al-Khaled,Sanyam Bajimaya,Sagun K C,Tsengelmaa Chuluunbat,Bayalag Munkhuu,Prema Subramanian,Narendran Venkatapathy,Karyn E Jonas,Joelle A Hallak,R V Paul Chan,Michael F Chiang,Jayashree Kalpathy-Cramer,J Peter Campbell
Importance Retinopathy of prematurity (ROP) is a leading cause of preventable blindness that disproportionately affects children born in low- and middle-income countries (LMICs). In-person and telemedical screening examinations can reduce this risk but are challenging to implement in LMICs owing to the multitude of at-risk infants and lack of trained ophthalmologists. Objective To implement an ROP
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Persistent Vascular Lesion in a Young Boy. JAMA Ophthalmol. (IF 8.253) Pub Date : 2022-07-07 Tonya Lee,Mansoor Movaghar,Catherine Y Liu
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County-Level Variation in the Prevalence of Visual Acuity Loss or Blindness in the US. JAMA Ophthalmol. (IF 8.253) Pub Date : 2022-07-07 Elizabeth A Lundeen,Abraham D Flaxman,John S Wittenborn,Zeb Burke-Conte,Rohit Gulia,Jinan Saaddine,David B Rein
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Association Between Ganglion Cell Complex Thinning and Vision-Related Quality of Life in Glaucoma. JAMA Ophthalmol. (IF 8.253) Pub Date : 2022-06-30 Takashi Nishida,Sasan Moghimi,Vahid Mohammadzadeh,Jo-Hsuan Wu,Maya L M Yamane,Alireza Kamalipour,Golnoush Mahmoudinezhad,Eleonora Micheletti,Jeffrey M Liebmann,Massimo A Fazio,Christopher A Girkin,Linda M Zangwill,Robert N Weinreb
Importance Faster structural changes may be associated with worse vision-related quality of life in patients with glaucoma. Objectives To evaluate the association between the rate of ganglion cell complex thinning and the Vision Function Questionnaire in glaucoma. Design, Setting, and Participants This retrospective analysis of a longitudinal cohort was designed in October 2021. Patients were enrolled
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Pigmented Corneal Mass in a 59-Year-Old Man With Cutaneous Melanoma. JAMA Ophthalmol. (IF 8.253) Pub Date : 2022-06-23 Nita G Valikodath,Abdulrahman Rageh,Miguel A Materin
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Repeatability and Discriminatory Power of Chart-Based Visual Function Tests in Individuals With Age-Related Macular Degeneration: A MACUSTAR Study Report. JAMA Ophthalmol. (IF 8.253) Pub Date : 2022-06-23 Hannah M P Dunbar,Charlotte Behning,Amina Abdirahman,Bethany E Higgins,Alison M Binns,Jan H Terheyden,Nadia Zakaria,Stephen Poor,Robert P Finger,Sergio Leal,Frank G Holz,Matthias Schmid,David P Crabb,Gary S Rubin,Ulrich F O Luhmann,
Importance There is a need for validated clinical end points that are reliably able to quantify potential therapeutic effects of future treatments targeting age-related macular degeneration (AMD) before the onset of serious visual impairment. Objective To assess the reliability and discriminatory power of 5 simple chart-based visual function (VF) tests as potential measures for clinical trial end points
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Furthering the Adoption of Digital Imaging and Communications in Medicine Standards in Ophthalmology. JAMA Ophthalmol. (IF 8.253) Pub Date : 2022-06-23 Dinah Chen,Andrew Wronka,Lama A Al-Aswad
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Cost of Ranibizumab Port Delivery System vs Intravitreal Injections for Patients With Neovascular Age-Related Macular Degeneration. JAMA Ophthalmol. (IF 8.253) Pub Date : 2022-07-01 Shefali Sood,Jordan Mandell,Arjun Watane,Scott Friedman,Ravi Parikh
Importance The study team investigated costs associated with the ranibizumab port delivery system (PDS) for neovascular age-related macular (nAMD), an alternative to conventional intravitreal anti-vascular endothelial growth factor (VEGF) injections. Objective To investigate costs of intravitreal anti-VEGF injections vs ranibizumab PDS for patients with neovascular AMD (nAMD). Design, Setting, and
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Is There a Cost Benefit to the Ranibizumab Port Delivery System? JAMA Ophthalmol. (IF 8.253) Pub Date : 2022-07-01 Shriji Patel,Paul Sternberg
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Inadvertent Ocular Perforation Caused by Traditional Acupuncture. JAMA Ophthalmol. (IF 8.253) Pub Date : 2022-06-16 Peng Wu,Na Li,Lei Gao
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Extensive Myelination of the Retinal Nerve Fiber Layer. JAMA Ophthalmol. (IF 8.253) Pub Date : 2022-06-16 Deepthi Slesser,Divya Deepthi Syamala,Pratyusha Ganne
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Orbital Rhabdomyosarcoma With Unusual Histopathology in a Young Adult. JAMA Ophthalmol. (IF 8.253) Pub Date : 2022-06-16 Tessnim R Ahmad,Meleha Ahmad,Robert Kersten
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Blue Sclera and Retinal Hyperpigmentation in a Patient With Long-term Minocycline Use. JAMA Ophthalmol. (IF 8.253) Pub Date : 2022-06-16 Marissa Patel,Andreas M Wingert,Jayanth Sridhar
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Patient Preference and Treatment Satisfaction With a Port Delivery System for Ranibizumab vs Intravitreal Injections in Patients With Neovascular Age-Related Macular Degeneration: A Randomized Clinical Trial. JAMA Ophthalmol. (IF 8.253) Pub Date : 2022-06-16 Margaret A Chang,Audrey Kapre,Derrick Kaufman,David R Kardatzke,Melvin Rabena,Shienal Patel,Ashwini Bobbala,Shamika Gune,Anne Fung,Gene Wallenstein
Importance The port delivery system (PDS) with ranibizumab has demonstrated noninferior and equivalent efficacy compared with monthly intravitreal injections of ranibizumab, an anti-vascular endothelial growth factor (VEGF) agent, in patients with neovascular age-related macular degeneration (nAMD), but evaluating patient preference is important to help inform clinical decision-making. Objective Evaluate
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Patient-Reported Outcome Measures in a Clinical Trial of the Port Delivery System With Ranibizumab. JAMA Ophthalmol. (IF 8.253) Pub Date : 2022-06-16 Wesley T Beaulieu,Adam R Glassman
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Middle-aged Woman With Atypical Upper Eyelid Retraction. JAMA Ophthalmol. (IF 8.253) Pub Date : 2022-06-16 Natalie A Homer,Morgan Darrow
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Changes in Optic Nerve Head and Retinal Morphology During Spaceflight and Acute Fluid Shift Reversal. JAMA Ophthalmol. (IF 8.253) Pub Date : 2022-06-16 Laura P Pardon,Brandon R Macias,Connor R Ferguson,Scott H Greenwald,Robert Ploutz-Snyder,Irina V Alferova,Doug Ebert,Scott A Dulchavsky,Alan R Hargens,Michael B Stenger,Steven S Laurie
Importance Countermeasures that reverse the headward fluid shift experienced in weightlessness have the potential to mitigate spaceflight-associated neuro-ocular syndrome. This study investigated whether use of the countermeasure lower-body negative pressure during spaceflight was associated with changes in ocular structure. Objective To determine whether changes to the optic nerve head and retina
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Early-Onset TIMP3-Related Retinopathy Associated With Impaired Signal Peptide. JAMA Ophthalmol. (IF 8.253) Pub Date : 2022-07-01 Bin Guan,Laryssa A Huryn,Andrew B Hughes,Zhiyu Li,Chelsea Bender,Delphine Blain,Amy Turriff,Catherine A Cukras,Robert B Hufnagel
Importance Sorsby fundus dystrophy is a typically adult-onset maculopathy with high risk for choroidal neovascularization. Sorsby fundus dystrophy, inherited as an autosomal dominant fully penetrant trait, is associated with TIMP3 variants that cause protein aggregation in the extracellular matrix. Objective To evaluate the phenotype and underlying biochemical mechanism of disease-causing TIMP3 variants
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Another Disappointment for ω-3 Fatty Acid and Dry Eye Disease. JAMA Ophthalmol. (IF 8.253) Pub Date : 2022-07-01 Penny A Asbell,Maureen G Maguire
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Associations Between the Global Cognitive Performance and the Optical Coherence Tomography Optic-Nerve Measurements-Reply. JAMA Ophthalmol. (IF 8.253) Pub Date : 2022-07-01 Ashleigh Barrett-Young,Richie Poulton
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Efficacy of Marine ω-3 Fatty Acid Supplementation vs Placebo in Reducing Incidence of Dry Eye Disease in Healthy US Adults: A Randomized Clinical Trial. JAMA Ophthalmol. (IF 8.253) Pub Date : 2022-07-01 William G Christen,Nancy R Cook,JoAnn E Manson,Julie E Buring,I-Min Lee,Vadim Bubes,Georgina Friedenberg,Rimma Dushkes,Douglas Smith,Debra A Schaumberg,
Importance Results of several small randomized clinical trials have suggested that supplements of marine ω-3 fatty acids may be beneficial in treating signs and symptoms of dry eye disease (DED). However, randomized clinical trial data to examine whether ω-3 fatty acid supplements can prevent DED are lacking. Objective To evaluate whether long-term daily supplementation with marine ω-3 fatty acids
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Associations Between the Global Cognitive Performance and the Optical Coherence Tomography Optic-Nerve Measurements. JAMA Ophthalmol. (IF 8.253) Pub Date : 2022-07-01 Muhammad Z Chauhan,Abdelrahman M Elhusseiny
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Sudden-Onset Monocular Blurry Vision in a Young Woman. JAMA Ophthalmol. (IF 8.253) Pub Date : 2022-07-01 Ines Lains,Mohammad Dahrouj,Dean Eliott
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Associations Between the Global Cognitive Performance and the Optical Coherence Tomography Optic-Nerve Measurements. JAMA Ophthalmol. (IF 8.253) Pub Date : 2022-07-01 Zhiqiang Guan,Kunliang Qiu,Mingzhi Zhang
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Association Between Retinal Microanatomy in Preterm Infants and 9-Month Visual Acuity. JAMA Ophthalmol. (IF 8.253) Pub Date : 2022-07-01 Kai R Seely,Shwetha Mangalesh,Liangbo L Shen,Brendan McGeehan,Gui-Shuang Ying,Neeru Sarin,Lejla Vajzovic,S Grace Prakalapakorn,Sharon F Freedman,Cynthia A Toth,
Importance Preterm infants are at risk for poor visual acuity (VA) outcomes, even without retinal problems on ophthalmoscopy. Infant retinal microanatomy may provide insight as to potential causes. Objective To evaluate the association between preterm infant retinal microanatomy and VA at 9 months' corrected age. Design, Setting, and Participants This prospective observational study took place from
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Long-term Outcomes of Adding Lutein/Zeaxanthin and ω-3 Fatty Acids to the AREDS Supplements on Age-Related Macular Degeneration Progression: AREDS2 Report 28. JAMA Ophthalmol. (IF 8.253) Pub Date : 2022-07-01 Emily Y Chew,Traci E Clemons,Elvira Agrón,Amitha Domalpally,Tiarnán D L Keenan,Susan Vitale,Claire Weber,Douglas C Smith,William Christen,
Importance After the Age-Related Eye Disease Study 2 (AREDS2) study, the beta carotene component was replaced by lutein/zeaxanthin for the development of the revised AREDS supplement. However, it is unknown if the increased risk of lung cancer observed in those assigned beta carotene persists beyond the conclusion of the AREDS2 trial and if there is a benefit of adding lutein/zeaxanthin to the original
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Progressive Vision Loss in a Child With Cognitive Impairments. JAMA Ophthalmol. (IF 8.253) Pub Date : 2022-06-02 Ashley Lopez-Cañizares,Piero Carletti,Audina M Berrocal
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Integrated Visualization Highlighting Retinal Changes in Retinopathy of Prematurity From 3-Dimensional Optical Coherence Tomography Data. JAMA Ophthalmol. (IF 8.253) Pub Date : 2022-07-01 Shwetha Mangalesh,Kai R Seely,Du Tran-Viet,Vincent Tai,Xi Chen,S Grace Prakalapakorn,Sharon F Freedman,Cynthia A Toth,
Importance Early diagnosis of plus disease is critical in the management of retinopathy of prematurity (ROP). However, there is substantial interexpert disagreement in the diagnosis of plus disease based on vascular changes alone. Information derived from optical coherence tomography (OCT) may help characterize the severity of vascular and structural abnormalities in ROP. Objective To describe integrated
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Elevated Intraocular Pressure With Visual Deterioration in a Pseudophakic Eye. JAMA Ophthalmol. (IF 8.253) Pub Date : 2022-07-01 Thomas Falb,Ewald Lindner