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Dynamic Risk of Systemic Complement Activation With Time to Progression to Advanced Age-Related Macular Degeneration JAMA Ophthalmol. (IF 7.8) Pub Date : 2025-06-12 Anne M. Lynch, Nathan C. Grove, Brandie D. Wagner, Alan G. Palestine, V. Michael Holers, Ashley A. Frazer-Abel, Ramya Gnanaraj, Andres Lisker-Cervantes, Jennifer L. Patnaik, Talisa E. de Carlo Forest, Emily A. Auer, Arden J. McReynolds, Marc T. Mathias, Niranjan Manoharan, Santiago Rodriquez De Cordoba, Naresh Mandava
ImportanceUnderstanding the relationship between longitudinally measured systemic complement factors and intermediate AMD (iAMD) progression may enable the introduction of systemic therapeutics earlier in the disease course, before vision loss occurs.ObjectiveTo determine the contribution of longitudinal measures of systemic complement factors and ratios to time to progression to advanced AMD (geographic
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Capsular Tension Ring Implantation for Intraocular Lens Position JAMA Ophthalmol. (IF 7.8) Pub Date : 2025-06-12 Haowen Lin, Yu Zhang, Xiaohang Xie, Xuhua Tan, Ling Jin, Jiaqing Zhang, Lixia Luo, Yizhi Liu
ImportanceThere is currently no consensus regarding the association of capsular tension ring (CTR) on intraocular lens (IOL) position or the indications for its implantation.ObjectiveTo evaluate the association of CTR implantation on IOL position.Data SourcesPubMed, Embase, and Cochrane Library were searched from their inception to October 18, 2024.Study SelectionRandomized clinical trials (RCTs) or
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Should We Be Concerned About Glucagon-Like Peptide-1 Receptor Agonists? JAMA Ophthalmol. (IF 7.8) Pub Date : 2025-06-05 Brian L VanderBeek
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Beyond Spherical Equivalent and Axial Length in Myopia. JAMA Ophthalmol. (IF 7.8) Pub Date : 2025-06-05 Xiu Juan Zhang,Connie H Y Lai,Kendrick Co Shih
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Diagnosis of Primary Open-Angle Glaucoma and Mental Health Status. JAMA Ophthalmol. (IF 7.8) Pub Date : 2025-06-05 Mae O Gordon,Feng Gao,John Burkland,James D Brandt,Julia B Huecker,J Phillip Miller,Pradeep Ramulu,Michael A Kass,
Importance Some patients may become stressed when they are informed they have developed glaucoma. Clinicians should be aware that informing patients of the diagnosis of glaucoma might be associated with a reduction in the patient's mental health. Objective To test whether mental health status as assessed by the National Eye Institute's Visual Function Questionnaire-25 (VFQ) decreases in patients with
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Appreciating the Role of Mental Health in Glaucoma Diagnosis and Care. JAMA Ophthalmol. (IF 7.8) Pub Date : 2025-06-05 Gerald McGwin,Cynthia Owsley
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Fundus Refraction Offset as an Individualized Myopia Biomarker JAMA Ophthalmol. (IF 7.8) Pub Date : 2025-06-05 Fabian Yii, Ian J. C. MacCormick, Niall Strang, Miguel O. Bernabeu, Tom MacGillivray
ImportanceAs on-axis metrics, spherical equivalent refraction (SER) and axial length (AL) are limited in capturing individual-level differences in posterior segment anatomy.ObjectiveTo propose a fundus-level metric—fundus refraction offset (FRO)—and investigate its association with ocular parameters derived from optical coherence tomography (OCT).Design, Setting, and ParticipantsThis cross-sectional
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Glucagon-Like Peptide-1 Receptor Agonists and Risk of Neovascular Age-Related Macular Degeneration JAMA Ophthalmol. (IF 7.8) Pub Date : 2025-06-05 Reut Shor, Andrew Mihalache, Atefeh Noori, Renana Shor, Radha P. Kohly, Marko M. Popovic, Rajeev H. Muni
ImportanceGlucagon-like peptide-1 receptor agonists (GLP-1 RAs) are extensively used in treating diabetes and obesity, yet little is known about the long-term ocular effects of systemic prolonged exposure.ObjectiveTo evaluate the risk of developing neovascular age-related macular degeneration (nAMD) associated with the use of GLP-1 RAs in patients with diabetes.Design, Setting, and ParticipantsThis
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Contemplating the Laser Question for Primary Angle Closure Suspect. JAMA Ophthalmol. (IF 7.8) Pub Date : 2025-05-29 Steven J Gedde,Vikas Chopra,Kateki Vinod
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Bilateral Central Retinal Artery Occlusion After Paclitaxel in Breast Cancer JAMA Ophthalmol. (IF 7.8) Pub Date : 2025-05-29 Harsh H. Jain, Rabia Naaz, Tanya Sagar, Akshay Kothari, Aditya Kelkar, Sabyasachi Sengupta
This case report discusses development of central retinal artery occlusion in a patient undergoing chemotherapy for biopsy-proven stage 3 breast cancer with paclitaxel.
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Short-Term Ocular Biometric Changes as Predictors of Long-Term Angle Closure Progression JAMA Ophthalmol. (IF 7.8) Pub Date : 2025-05-29 Kendra L. Hong, Benjamin Y. Xu, Wei Wang, Austin Cho, Natalie M. Kistler, Paul J. Foster, Yuzhen Jiang, Tin Aung, David S. Friedman, Mingguang He
ImportanceBaseline ocular biometrics of the anterior segment forecast progression from primary angle closure suspect (PACS) to primary angle closure (PAC). As ocular biometrics change with aging, it is also important to understand the progression risk associated with these longitudinal anatomical changes.ObjectiveTo assess 18-month ocular biometric changes as risk factors for progression from PACS
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Malignant Transformation of Choroidal Indeterminate Melanocytic Tumors JAMA Ophthalmol. (IF 7.8) Pub Date : 2025-05-22 Arun D. Singh, Yehonatan Weinberger, Emily C. Zabor
ImportanceThe accuracy of the predicted risk of malignant transformation of a large choroidal nevus or indeterminate melanocytic tumor (IMT) is not known.ObjectiveTo estimate the risk of malignant transformation (predicted risk) in a cohort of patients with IMT of known outcomes (observed status; benign [large nevus] or malignant [small melanoma]).Design, Setting, and ParticipantsThis was a cohort
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A New Vision for Site-Neutral Policy JAMA Ophthalmol. (IF 7.8) Pub Date : 2025-05-22 Taylor Hall, Brian J. Miller, Fasika A. Woreta, Catherine L. Chen
This Viewpoint reviews the history of innovation in cataract surgery and site-neutral policies and suggests changes that could propel clinical innovation, reduce costs, and expand access to cataract care.
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Artificial Intelligence-Based Detection of Diabetic Retinopathy-Reply. JAMA Ophthalmol. (IF 7.8) Pub Date : 2025-05-22 Shreya A Shah,Prithvi Mruthyunjaya,Ravi Parikh
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Flying Babies and Swept-Source OCT-An Innovative Technique to Detect Childhood Glaucoma. JAMA Ophthalmol. (IF 7.8) Pub Date : 2025-05-22 Sylvia L Groth,Rachel W Kuchtey
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Utility of Swept-Source Anterior-Segment OCT as an In-Office Biomarker for Early Childhood Glaucoma JAMA Ophthalmol. (IF 7.8) Pub Date : 2025-05-22 Sushmita Kaushik, Ashok Kumar Singh, Faisal Thattaruthody, Vyshak Suresh, Anchal Gera, Shivangi Yadav, Surinder Singh Pandav
ImportanceEarly-onset childhood glaucoma usually is diagnosed based on signs and symptoms (such as a cloudy cornea, buphthalmos, or excessive lacrimation). However, the signs and symptoms can overlap with other congenital conditions, making differentiation important. Swept-source anterior-segment optical coherence tomography (SS-ASOCT) may offer a rapid, noninvasive alternative to assess the trabecular
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Artificial Intelligence-Based Detection of Diabetic Retinopathy. JAMA Ophthalmol. (IF 7.8) Pub Date : 2025-05-22 Flora Lum
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Visual Acuity and Complications at Age 7 Years Following Bilateral Secondary Intraocular Lens Implantation at 2 to Younger Than 6 Years for Pediatric Aphakia JAMA Ophthalmol. (IF 7.8) Pub Date : 2025-05-15 Kun Hu, Yu Zhang, Wan Chen, Hui Chen, Qiwei Wang, Anqi He, Tingfeng Qin, Xin Li, Ling Xia, Yizhi Liu, Weirong Chen
ImportanceThe optimal timing for secondary intraocular lens (IOL) implantation in children with bilateral aphakia remains uncertain, with important implications for long-term visual outcomes and the risk of complications such as glaucoma. Determining when to implant to achieve the best visual outcomes while minimizing complications is critical for improving clinical decision-making in pediatric cataract
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Child With Ruptured Soemmering Ring and Visual Axis Reopacification JAMA Ophthalmol. (IF 7.8) Pub Date : 2025-05-15 Jiaxing Wang, Ramsey Yusuf, Ta Chen Chang
This case report describes a diagnosis of ruptured Soemmering ring and visual axis reopacification 14 months after cataract surgery in a child aged 2 years.
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Drusen Regression After Macular Hole Surgery. JAMA Ophthalmol. (IF 7.8) Pub Date : 2025-05-15 Shannan Berzack,Prashant K Parekh
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Growing Congenital Simple Hamartoma of the Retinal Pigment Epithelium. JAMA Ophthalmol. (IF 7.8) Pub Date : 2025-05-15 Giorgio Gaspari,Gaspare Monaco,Giuseppe Casalino
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Bilateral Paracentral Corneal Opacity in a Man Aged 22 Years JAMA Ophthalmol. (IF 7.8) Pub Date : 2025-05-15 Keli Mao, Zixiang Zhao, Man Yu
This case report describes a diagnosis of Schnyder crystalline corneal dystrophy in a man aged 22 years with progressive bilateral corneal opacification over 5 years and no visual symptoms.
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Encouraging News for Children With Aphakia. JAMA Ophthalmol. (IF 7.8) Pub Date : 2025-05-15 William V Good
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Application of Artificial Intelligence to Deliver Healthcare From the Eye JAMA Ophthalmol. (IF 7.8) Pub Date : 2025-05-08 Robert N. Weinreb, Aaron Y. Lee, Sally L. Baxter, Richard W. J. Lee, Theodore Leng, Michael V. McConnell, Nevin W. El-Nimri, David C. Rhew
ImportanceOculomics is the science of analyzing ocular data to identify, diagnose, and manage systemic disease. This article focuses on prescreening, its use with retinal images analyzed by artificial intelligence (AI), to identify ocular or systemic disease or potential disease in asymptomatic individuals. The implementation of prescreening in a coordinated care system, defined as Healthcare From
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DNA Assays to Detect and Characterize RB1 Mosaicism in Retinoblastoma. JAMA Ophthalmol. (IF 7.8) Pub Date : 2025-05-08 Patricia Chévez-Barrios,Sharon E Plon,Zejuan Li
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Detection and Characterization of RB1 Mosaicism in Patients With Retinoblastoma Receiving cfDNA Test JAMA Ophthalmol. (IF 7.8) Pub Date : 2025-05-08 Chuan Gao, Juber Patel, Melissa Robbins, Erika Gedvilaite, Anita S. Bowman, Kanika Arora, Chad Vanderbilt, A. Rose Brannon, Danielle N. Friedman, Jennifer Kennedy, Elise Fiala, Ozge Ceyhan-Birsoy, Ira J. Dunkel, Britta Weigelt, Jasmine H. Francis, Jorge S. Reis-Filho, David H. Abramson, Diana Mandelker
ImportancePlasma cell-free DNA (cfDNA) testing is increasingly used for disease diagnosis and monitoring in retinoblastoma, with RB1 allele fraction in cfDNA actively corresponding to disease status and treatment response. However, while RB1 mosaicism has been reported in retinoblastoma, its clinical implications and potential impact on cfDNA testing remain unclear.ObjectivesTo identify RB1 mosaicism
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Characterization of Belantamab Mafodotin–Induced Corneal Changes in Patients With Multiple Myeloma JAMA Ophthalmol. (IF 7.8) Pub Date : 2025-05-08 Vivian Lee, Malin Hultcrantz, Stephanie Petrone, Eric W. Lewis, Hussam Banna, Eben Lichtman, Praneetha Thulasi, Anjulie A. Quick, Bennie H. Jeng, Sarah B. Sunshine, Jasmine H. Francis, Julia Canestraro, Asim V. Farooq, Peter Clements, Nicola Robertson, Mark Burman, Tom McKevitt, Herbert Struemper, Lucinda Weir
ImportanceOcular surface events are a class effect of microtubule-inhibitor payload-containing antibody-drug conjugates (ADCs); the mechanism underlying these events has not been fully elucidated.ObjectiveTo characterize corneal epithelial changes in patients with relapsed or refractory multiple myeloma (RRMM) treated with belantamab mafodotin, a maleimidocaproyl monomethyl auristatin-F (MMAF)–containing
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Noninfectious Intraocular Inflammation After Intravitreal Aflibercept JAMA Ophthalmol. (IF 7.8) Pub Date : 2025-05-01 Karoline E. Binder, Nathalie Bleidißel, Peter Charbel Issa, Mathias Maier, Leonard M. Coulibaly
ImportanceAflibercept, 8 mg, is an anti–vascular endothelial growth factor (VEGF) formulation for neovascular age-related macular degeneration (nAMD) and diabetic macular edema (DME). While clinical trials report a comparable safety profile as aflibercept, 2 mg, clinical practice setting (so-called real-world) data on the incidence of intraocular inflammation (IOI) should be of value.ObjectiveTo determine
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Gender Differences in Case Volume Among Ophthalmology Resident Graduates, 2014-2023 JAMA Ophthalmol. (IF 7.8) Pub Date : 2025-05-01 Susan M. Culican, Misha F. Syed, Yoon Soo Park, Sean O. Hogan
ImportanceA previous multisite study found gender differences in cataract and total surgical volume among US residency programs. Whether that was representative of all ophthalmology residents in the US is unclear.ObjectiveTo determine whether reported surgical volume among US ophthalmology resident graduates varied by self-reported gender or by underrepresented in medicine (URiM) status.Design, Setting
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Training Inequities in Ophthalmology-Insights From Educators. JAMA Ophthalmol. (IF 7.8) Pub Date : 2025-05-01 Fasika Woreta,Laura K Green,Grace Sun
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Repeated Low-Level Red Light-More Than Meets the Eye? JAMA Ophthalmol. (IF 7.8) Pub Date : 2025-04-24 Jacque L Duncan
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Scientific Data Fabrication and AI-Pandora's Box. JAMA Ophthalmol. (IF 7.8) Pub Date : 2025-04-24 Hong-Uyen Hua
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Human Papillomavirus and Thyroid Eye Disease JAMA Ophthalmol. (IF 7.8) Pub Date : 2025-04-24 Ishita Garg, Benjamin I. Meyer, Ryan A. Gallo, Sara T. Wester, Daniel Pelaez
ImportanceThyroid eye disease (TED) is an autoimmune disease characterized by orbital inflammation and tissue remodeling. TED pathogenesis is poorly understood but is linked to autoantibodies to thyroid-stimulating hormone receptor (TSHR) and insulinlike growth factor-1 receptor (IGF-1R).ObjectiveTo explore the potential involvement of viral infections in TED pathogenesis.Design, Setting, and ParticipantsIn
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Cone Density Changes After Repeated Low-Level Red Light Treatment in Children With Myopia JAMA Ophthalmol. (IF 7.8) Pub Date : 2025-04-24 Xinyi Liao, Jifeng Yu, Yuzhuo Fan, Yixuan Zhang, Yan Li, Xuewei Li, Hongxin Song, Kai Wang
ImportanceRepeated low-level red light (RLRL) therapy has emerged as a potential intervention for controlling myopia progression in children. However, its long-term effects on retinal photoreceptors remain relatively unknown.ObjectiveTo evaluate changes associated with RLRL therapy on cone photoreceptor density in children with myopia using high-resolution adaptive optics scanning laser ophthalmoscopy
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Exploring Detection Methods for Synthetic Medical Datasets Created With a Large Language Model JAMA Ophthalmol. (IF 7.8) Pub Date : 2025-04-24 Andrea Taloni, Giulia Coco, Marco Pellegrini, Matthias Wjst, Niccolò Salgari, Giovanna Carnovale-Scalzo, Vincenzo Scorcia, Massimo Busin, Giuseppe Giannaccare
ImportanceRecently, it was proved that the large language model Generative Pre-trained Transformer 4 (GPT-4; OpenAI) can fabricate synthetic medical datasets designed to support false scientific evidence.ObjectiveTo uncover statistical patterns that may suggest fabrication in datasets produced by large language models and to improve these synthetic datasets by attempting to remove detectable marks
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Retinal Proliferative Membrane Caused by Picosecond Laser. JAMA Ophthalmol. (IF 7.8) Pub Date : 2025-04-17 Jingyuan Yang,Shan Wu,Youxin Chen
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Golden Eye on Diabetic Retinopathy Screening. JAMA Ophthalmol. (IF 7.8) Pub Date : 2025-04-17 Jason A W Giger,Maximilian Pfau,Hanna Zuche
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Swept-Source Anterior-Segment OCT of Lens Subluxation in Marfan Syndrome JAMA Ophthalmol. (IF 7.8) Pub Date : 2025-04-17 Junru Yan, Simon S. M. Fung, Edmund Tsui
This case report highlights a case of lens subluxation in Marfan syndrome diagnosed using swept-source anterior-segment optical coherence tomography (OCT).
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Bilateral Fundus Hypopigmentation in a Patient With Glaucoma JAMA Ophthalmol. (IF 7.8) Pub Date : 2025-04-17 Zhonghua Luo, Shanshan Yu, Jingjing Huang
This case report discusses a diagnosis of bilateral fundus hypopigmentation in a patient with glaucoma and a history of COVID-19 infection 1 year prior.
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Two-Year Outcomes of Phacogoniotomy vs Phacotrabeculectomy for Advanced Primary Angle-Closure Glaucoma With Cataract: A Noninferiority Randomized Clinical Trial. JAMA Ophthalmol. (IF 7.8) Pub Date : 2025-04-17 Yunhe Song,Sujie Fan,Li Tang,Fengbin Lin,Fei Li,Aiguo Lv,Xiaoyan Li,Tingli Wen,Lan Lu,Meichun Xiao,Lin Xie,Xiaomin Zhu,Guangxian Tang,Hengli Zhang,Xiaowei Yan,Huiping Yuan,Wulian Song,Yangfan Yang,Jiangang Xu,Fengqi Zhou,Zhenyu Wang,Ling Jin,Xiaohong Liang,Minwen Zhou,Xiaohuan Zhao,Weirong Chen,Ki-Ho Park,Keith Barton,Tin Aung,Clement C Tham,Dennis S C Lam,Robert N Weinreb,Ningli Wang,Xiulan Zhang
Importance Intraocular pressure (IOP) reduction with phacogoniotomy (phacoemulsification plus goniosynechialysis plus goniotomy) was not less than that of phacotrabeculectomy for advanced primary angle-closure glaucoma (PACG) with cataract at 1-year follow-up, but longer-term outcomes are needed. Objective To investigate if phacogoniotomy is noninferior to phacotrabeculectomy for advanced PACG with
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Is Phacogoniotomy the Best Surgery for PACG and Cataract? JAMA Ophthalmol. (IF 7.8) Pub Date : 2025-04-17 David S Friedman,Gus Gazzard,Paul J Foster
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Peripheral Iridectomy With Goniosynechialysis and Goniotomy vs Trabeculectomy for Advanced PACG: A Randomized Clinical Trial. JAMA Ophthalmol. (IF 7.8) Pub Date : 2025-04-17 Fengbin Lin,Aiguo Lv,Fei Li,Yunhe Song,Lin Xie,Xiaomin Zhu,Li Tang,Yao Zhang,Jingjing Huang,Guangxian Tang,Hengli Zhang,Lan Lu,Meichun Xiao,Jiangang Xu,Xin Nie,Mengfei Liao,Yangfan Yang,Kai Gao,Huiping Yuan,Wulian Song,Chengguo Zuo,Ping Lu,Xiaowei Yan,Fengqi Zhou,Zhenyu Wang,Ling Jin,Yuying Peng,Weirong Chen,Keith Barton,Ki Ho Park,Tin Aung,Dennis S C Lam,Robert N Weinreb,Ningli Wang,Clement C Tham
Importance The safety and effectiveness of combining surgical peripheral iridectomy (SPI) with goniosynechialysis (GSL) and goniotomy (GT) vs trabeculectomy for intraocular pressure (IOP) reduction remains unknown. Objective To investigate the safety and effectiveness at 1 year of SPI + GSL + GT vs trabeculectomy in advanced primary angle-closure glaucoma (PACG) without cataract. Design, Setting, and
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Telehealth for Children With Congenital Ectopia Lentis? JAMA Ophthalmol. (IF 7.8) Pub Date : 2025-05-01 Raymond T Kraker
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Race and Vision Outcomes in Ranibizumab-Treated Participants With Diabetic Macular Edema JAMA Ophthalmol. (IF 7.8) Pub Date : 2025-04-10 M. Ali Khan, Lauren Hill, Ivaylo Stoilov, Julia A. Haller
ImportanceVision outcomes in response to anti–vascular endothelial growth factor therapy for diabetic macular edema (DME) may differ between races. This meta-analysis investigated whether vision outcomes differed among racial subgroups treated with ranibizumab for DME in a clinical trial setting.ObjectiveTo assess the impact of race on vision outcomes in participants with DME treated with ranibizumab
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Social Media Interventions and Postoperative Follow-Up in Congenital Ectopia Lentis JAMA Ophthalmol. (IF 7.8) Pub Date : 2025-04-10 Yiyuan Ma, Xinyu Zhang, Ling Jin, Siyuan Liu, Xiaolin Liang, Qian Ye, Xinxin Liu, Nathan Congdon, Danying Zheng, Guangming Jin
ImportanceCongenital ectopia lentis (CEL), often associated with systemic diseases such as Marfan syndrome, requires rigorous postoperative follow-up to reduce the risk of severe complications. However, follow-up rates are frequently suboptimal, indicating an urgent need for effective interventions to improve adherence.ObjectiveTo assess the effect of WeChat (Tencent Holdings Ltd), a social media smartphone
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Evaluation of AI Summaries on Interdisciplinary Understanding of Ophthalmology Notes JAMA Ophthalmol. (IF 7.8) Pub Date : 2025-04-04 Prashant D. Tailor, Haley S. D’Souza, Clara M. Castillejo Becerra, Heidi M. Dahl, Neil R. Patel, Tyler M. Kaplan, Darrell Kohli, Erick D. Bothun, Brian G. Mohney, Andrea A. Tooley, Keith H. Baratz, Raymond Iezzi, Andrew J. Barkmeier, Sophie J. Bakri, Gavin W. Roddy, David Hodge, Arthur J. Sit, Matthew R. Starr, John J. Chen
ImportanceSpecialized ophthalmology terminology limits comprehension for nonophthalmology clinicians and professionals, hindering interdisciplinary communication and patient care. The clinical implementation of large language models (LLMs) into practice has to date been relatively unexplored.ObjectiveTo evaluate LLM–generated plain language summaries (PLSs) integrated into standard ophthalmology notes
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Risk of Developing Pediatric Uveitis Among Patients With Early-Onset Atopic Dermatitis JAMA Ophthalmol. (IF 7.8) Pub Date : 2025-04-04 Yung-Yu Chu, Cheng-Hao Sung, Yu-Shiuan Lin, Chung-Han Ho, Yi-Chen Chen, Wan-Ju Annabelle Lee, Shu-Chun Kuo
ImportanceThe relationship between atopic dermatitis (AD) and pediatric uveitis may be underexplored, warranting large-scale, multicenter studies.ObjectiveTo evaluate the risk of pediatric uveitis among children with early-onset AD compared with a matched control population.Design, Setting, and ParticipantsThis cohort study used aggregated electronic health records of US patients with early-onset AD
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Plain Language Summaries to Bolster Team-Based Care. JAMA Ophthalmol. (IF 7.8) Pub Date : 2025-05-01 Patrice M Hicks,Rithambara Ramachandran,Paula Anne Newman-Casey
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Cocoa Flavanol Supplementation and Risk of Age-Related Macular Degeneration: An Ancillary Study of the COSMOS Randomized Clinical Trial. JAMA Ophthalmol. (IF 7.8) Pub Date : 2025-05-01 William G Christen,Pamela M Rist,M Vinayaga Moorthy,Douglas C Smith,Beth Holman,Allison Clar,Robert J Glynn,Julie A Mares,Lucia Sobrin,Aladdin H Shadyab,Matthew A Allison,Amy E Millen,JoAnn E Manson,Howard D Sesso,
Importance Abnormalities of choroidal blood flow in the eye are associated with occurrence of age-related macular degeneration (AMD). Cocoa flavanols show beneficial effects on vascular risk factors in small and short-term trials and may help reduce AMD risk. Objective To examine whether daily supplementation with cocoa extract, a source of flavanols, prevents the development or progression of AMD
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Conflicting Results-Need for More Transparent and Reproducible Research. JAMA Ophthalmol. (IF 7.8) Pub Date : 2025-05-01 Cindy X Cai,Michelle Hribar,Akihiko Nishimura
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Conjunctival Melanoma With Invasion of a LASIK Flap Interface JAMA Ophthalmol. (IF 7.8) Pub Date : 2025-03-27 Tyler Bahr, Jenna Krivit, Diva R. Salomao, Keith H. Baratz, Lauren A. Dalvin
This case report describes invasion of a laser-assisted in situ keratomileusis (LASIK) flap interface by conjunctival malignant melanoma in a male patient aged 71 years.
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Semaglutide and Nonarteritic Anterior Ischemic Optic Neuropathy Risk Among Patients With Diabetes JAMA Ophthalmol. (IF 7.8) Pub Date : 2025-03-27 Alan Y. Hsu, Hou-Ting Kuo, Yu-Hsun Wang, Chun-Ju Lin, Yi-Ching Shao, Chun-Chi Chiang, Ning-Yi Hsia, Chun-Ting Lai, Hsin Tseng, Bing-Qi Wu, Huan-Sheng Chen, Yi-Yu Tsai, Min-Yen Hsu, James Cheng-Chung Wei
ImportanceRecent studies have suggested an association between nonarteritic anterior ischemic optic neuropathy (NAION) with semaglutide usage. However, the limitations of those analyses warrant further investigation, given the frequency of use of these medications in people with and without diabetes.ObjectiveTo investigate the association between semaglutide use and the risk of NAION among patients
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The OHDSI Network in Ophthalmology—The Promise of Observational Health Data JAMA Ophthalmol. (IF 7.8) Pub Date : 2025-03-27 Michelle R. Hribar, Cindy X. Cai, Kerry E. Goetz, George Hripcsak
This Viewpoint discusses how the Observational Health Data Sciences and Informatics community’s health data network supports biomedical research in ophthalmology by providing access to a large, standardized dataset.
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Aflibercept With vs Without Reduced-Fluence Photodynamic Therapy for Polypoidal Choroidal Vasculopathy JAMA Ophthalmol. (IF 7.8) Pub Date : 2025-03-27 Yu Jeat Chong, Kelvin Yi Chong Teo, Wendy Wong, Anna C. S. Tan, Xinyi Su, Noa Gilead, Hiok Hong Chan, Farah Ibrahim, Beau Fenner, Charles Ong, Christopher Sun, Shaun Sim, Caroline Chee, Usha Chakravarthy, Chui Ming Gemmy Cheung
IMPORTANCEThe potential benefit of adding photodynamic therapy (PDT) to intravitreal aflibercept injection (IAI) in eyes with polypoidal choroidal vasculopathy (PCV) remains unclear.OBJECTIVETo compare the functional and anatomical benefit of combination therapy using reduced-fluence PDT (RF-PDT) plus IAI vs IAI monotherapy in participants with PCV.DESIGN, SETTING, AND PARTICIPANTSThis double-masked
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Cardiovascular Morbidity and Mortality After Amaurosis Fugax. JAMA Ophthalmol. (IF 7.8) Pub Date : 2025-05-01 Karen M Wai,Deanne K Loube,Nathan H Pham,Chase A Ludwig,Euna Koo,Prithvi Mruthyunjaya,Ehsan Rahimy
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High Myopia and Capsular Tension Rings-To Be or Not To Be? JAMA Ophthalmol. (IF 7.8) Pub Date : 2025-05-01 Eubee B Koo
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Importance of Population-Based Studies in Childhood Eye Disease-Seeing the Bigger Picture. JAMA Ophthalmol. (IF 7.8) Pub Date : 2025-05-01 Jonathan R Morse,Jeremy D Keenan,Julius T Oatts
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JAMA Ophthalmology-The Year in Review 2024: The Power of the JAMA Network. JAMA Ophthalmol. (IF 7.8) Pub Date : 2025-05-01 Neil M Bressler
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Prevalence and Severity of Astigmatism in Children After COVID-19 JAMA Ophthalmol. (IF 7.8) Pub Date : 2025-03-20 Ka Wai Kam, Erica Shing, Yuzhou Zhang, Xiu Juan Zhang, Arnold S. H. Chee, Mandy P. H. Ng, Patrick Ip, Wei Zhang, Alvin L. Young, Amanda French, Ian Morgan, Kathyrn Rose, Clement C. Tham, Chi Pui Pang, Li Jia Chen, Jason C. Yam
ImportanceAstigmatism can cause blurred vision at near and distance. It is common among schoolchildren and associated with ametropia. Although the COVID-19 pandemic generated a surge in myopia prevalence in children, the association with child astigmatism remains unknown.ObjectiveTo report the prevalence of refractive astigmatism and corneal astigmatism in schoolchildren from 2015 to 2023 and explore
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Capsular Tension Ring Implantation for Intraocular Lens Power Calculation in Highly Myopic Eyes JAMA Ophthalmol. (IF 7.8) Pub Date : 2025-03-20 Haowen Lin, Jiaqing Zhang, Aixia Jin, Yifan Zhang, Yu Zhang, Ling Jin, Yifan Xu, Xiaohang Xie, Xiaozhang Qiu, Boyufei Dai, Xuhua Tan, Lixia Luo, Yizhi Liu
ImportanceCapsular tension ring (CTR) implantation has been shown to reduce intraocular lens (IOL) decentration and tilt in high myopia. However, the effect of CTR implantation in highly myopic eyes on IOL power calculation remains unclear, particularly in new-generation formulas.ObjectiveTo evaluate the influence of CTR implantation on IOL power calculation in highly myopic eyes.Design, Setting, and