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Minimizing the risk of COVID-19 among patients on dialysis Nat. Rev. Nephrol. (IF 19.684) Pub Date : 2020-04-06 T. Alp Ikizler; Alan S. Kliger
Patients on haemodialysis or peritoneal dialysis are likely to be at increased risk of novel coronavirus disease (COVID-19). Preventive strategies must be implemented to minimize the risk of disease transmission in dialysis facilities, including education of staff and patients, screening for COVID-19 and separation of infected or symptomatic and non-infected patients.
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Controversies of renin–angiotensin system inhibition during the COVID-19 pandemic Nat. Rev. Nephrol. (IF 19.684) Pub Date : 2020-04-03 Andrew M. South; Laurie Tomlinson; Daniel Edmonston; Swapnil Hiremath; Matthew A. Sparks
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Regulatory approaches to stimulate innovative renal replacement therapies Nat. Rev. Nephrol. (IF 19.684) Pub Date : 2020-04-02 Fokko P. Wieringa; Murray I. Sheldon; Ana Hidalgo-Simon
Regulations for market access and reimbursement of medical devices vary across jurisdictions, complicating the development of innovative technologies for world-wide use; however, several converging regulatory principles are now emerging. Here we discuss approaches by which regulatory and related agencies can promote innovation and boost the effectiveness of regulatory processes to expedite patient
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eHealth in kidney care Nat. Rev. Nephrol. (IF 19.684) Pub Date : 2020-04-01 Chia-shi Wang; Elaine Ku
eHealth is gaining momentum in nephrology, although evidence for its efficacy remains unclear and challenges to its widespread adoption persist. Successful integration of eHealth into kidney care will require patient engagement to develop effective interventions and issues such as data validity, regulation, oversight and adequate infrastructure to be addressed.
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Mechanisms of cognitive dysfunction in CKD Nat. Rev. Nephrol. (IF 19.684) Pub Date : 2020-03-31 Davide Viggiano; Carsten A. Wagner; Gianvito Martino; Maiken Nedergaard; Carmine Zoccali; Robert Unwin; Giovambattista Capasso
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mGWAS: next generation genetic prediction in kidney disease Nat. Rev. Nephrol. (IF 19.684) Pub Date : 2020-03-30 Daniel Montemayor; Kumar Sharma
A recent metabolite genome-wide association study (mGWAS) investigated the relationship between genetic factors and the urine metabolome in kidney disease. The findings demonstrate that mGWAS hold promise for identifying novel genetic factors involved in adsorption, distribution, metabolism and excretion of metabolites and pharmaceuticals, as well as biomarkers for disease progression.
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Tools for the analysis of high-dimensional single-cell RNA sequencing data Nat. Rev. Nephrol. (IF 19.684) Pub Date : 2020-03-27 Yan Wu; Kun Zhang
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PEXIVAS challenges current ANCA-associated vasculitis therapy Nat. Rev. Nephrol. (IF 19.684) Pub Date : 2020-03-13 Adam Morris; Duvuru Geetha
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The evolving role of TonEBP as an immunometabolic stress protein Nat. Rev. Nephrol. (IF 19.684) Pub Date : 2020-03-10 Soo Youn Choi; Whaseon Lee-Kwon; Hyug Moo Kwon
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The tubular hypothesis of nephron filtration and diabetic kidney disease Nat. Rev. Nephrol. (IF 19.684) Pub Date : 2020-03-09 Volker Vallon; Scott C. Thomson
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The impact of chronic kidney disease on global health. Nat. Rev. Nephrol. (IF 19.684) Pub Date : 2020-03-06 Ellen F Carney
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Targeting angiogenesis and lymphangiogenesis in kidney disease. Nat. Rev. Nephrol. (IF 19.684) Pub Date : 2020-03-06 Katsuyuki Tanabe,Jun Wada,Yasufumi Sato
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Sensing of tubular flow and renal electrolyte transport. Nat. Rev. Nephrol. (IF 19.684) Pub Date : 2020-03-03 Eric H J Verschuren,Charlotte Castenmiller,Dorien J M Peters,Francisco J Arjona,René J M Bindels,Joost G J Hoenderop
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New insights into the obesity paradox in renal cell carcinoma. Nat. Rev. Nephrol. (IF 19.684) Pub Date : 2020-03-02 Chun Loo Gan,Daniel Y C Heng
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Targeting the progression of chronic kidney disease. Nat. Rev. Nephrol. (IF 19.684) Pub Date : 2020-02-14 Marta Ruiz-Ortega,Sandra Rayego-Mateos,Santiago Lamas,Alberto Ortiz,Raul R Rodrigues-Diez
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Long-term outcomes of acute kidney injury and strategies for improved care. Nat. Rev. Nephrol. (IF 19.684) Pub Date : 2020-02-12 Matthew T James,Meha Bhatt,Neesh Pannu,Marcello Tonelli
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Green nephrology. Nat. Rev. Nephrol. (IF 19.684) Pub Date : 2020-02-07 Katherine A Barraclough,John W M Agar
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The global epidemiology of hypertension. Nat. Rev. Nephrol. (IF 19.684) Pub Date : 2020-02-05 Katherine T Mills,Andrei Stefanescu,Jiang He
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Strategies to prevent kidney disease and its progression. Nat. Rev. Nephrol. (IF 19.684) Pub Date : 2020-01-31 Kamyar Kalantar-Zadeh,Philip K-T Li
The 2020 World Kidney Day campaign highlights the importance of prevention of chronic kidney disease. Various strategies and therapies are available to prevent disease before its onset (primary prevention), during early disease stages (secondary prevention) and for effective management of established disease to prevent dialysis (tertiary prevention).
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Are electronic health records ready for clinical trial use? Nat. Rev. Nephrol. (IF 19.684) Pub Date : 2020-01-27 Lucy Plumb,Dorothea Nitsch
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Author Correction: Reappraising the spectrum of AKI and hepatorenal syndrome in patients with cirrhosis Nat. Rev. Nephrol. (IF 19.684) Pub Date : 2020-01-27 Juan Carlos Q. Velez; George Therapondos; Luis A. Juncos
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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One step closer to alleviating uraemic pruritus. Nat. Rev. Nephrol. (IF 19.684) Pub Date : 2020-01-27 Elke Weisshaar,Robert F Ofenloch
The KALM-1 randomized double-blind placebo-controlled phase III trial showed that intravenous difelikefalin, a selective κ-opioid receptor agonist, significantly reduces itch intensity in haemodialysis patients with uraemic pruritus. However, 49% of difelikefalin-treated patients showed no improvement. In light of the increasing number of patients with end-stage renal disease, additional treatments
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Endothelium adapts to survive dehydration. Nat. Rev. Nephrol. (IF 19.684) Pub Date : 2020-01-20 Monica Wang
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Innate immunity in diabetic kidney disease. Nat. Rev. Nephrol. (IF 19.684) Pub Date : 2020-01-15 Sydney C W Tang,Wai Han Yiu
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Artificial intelligence approaches to improve kidney care. Nat. Rev. Nephrol. (IF 19.684) Pub Date : 2019-12-23 Parisa Rashidi,Azra Bihorac
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ApoC3 fires up monocytes to promote tissue damage. Nat. Rev. Nephrol. (IF 19.684) Pub Date : 2019-12-18 Monica Wang
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Design and application of single-cell RNA sequencing to study kidney immune cells in lupus nephritis. Nat. Rev. Nephrol. (IF 19.684) Pub Date : 2019-12-18 Deepak A Rao,Arnon Arazi,David Wofsy,Betty Diamond
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Exciting developments in the field of acute kidney injury. Nat. Rev. Nephrol. (IF 19.684) Pub Date : 2019-12-17 Chun-Te Huang,Kathleen D Liu
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CUBN variants uncouple proteinuria from kidney function. Nat. Rev. Nephrol. (IF 19.684) Pub Date : 2020-03-01 Catherine Quinlan
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The landscape of diabetic kidney disease transformed. Nat. Rev. Nephrol. (IF 19.684) Pub Date : 2020-02-01 Katherine R Tuttle
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Using single-cell technologies to map the human immune system - implications for nephrology. Nat. Rev. Nephrol. (IF 19.684) Pub Date : 2019-12-12 Benjamin J Stewart,John R Ferdinand,Menna R Clatworthy
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The power of one: advances in single-cell genomics in the kidney. Nat. Rev. Nephrol. (IF 19.684) Pub Date : 2020-02-01 Abbe R Clark,Anna Greka
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Recreating, expanding and using nephron progenitor populations. Nat. Rev. Nephrol. (IF 19.684) Pub Date : 2020-02-01 Melissa H Little,Kynan T Lawlor
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Proteomic signatures of clear cell renal cell carcinoma. Nat. Rev. Nephrol. (IF 19.684) Pub Date : 2020-03-01 Chad J Creighton
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Contribution of dedifferentiated proximal tubule cells to repair in acute kidney injury. Nat. Rev. Nephrol. (IF 19.684) Pub Date : 2020-02-01 Susan J Allison
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Type IV collagen and diabetic kidney disease. Nat. Rev. Nephrol. (IF 19.684) Pub Date : 2020-01-01 Jeffrey H Miner
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Reappraising the spectrum of AKI and hepatorenal syndrome in patients with cirrhosis. Nat. Rev. Nephrol. (IF 19.684) Pub Date : 2019-11-13 Juan Carlos Q Velez,George Therapondos,Luis A Juncos
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Kidney disease trials for the 21st century: innovations in design and conduct. Nat. Rev. Nephrol. (IF 19.684) Pub Date : 2019-10-31 William G Herrington,Natalie Staplin,Richard Haynes
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NAD+ homeostasis in renal health and disease. Nat. Rev. Nephrol. (IF 19.684) Pub Date : 2019-10-31 Kenneth M Ralto,Eugene P Rhee,Samir M Parikh
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Ketosis slows the progression of PKD Nat. Rev. Nephrol. (IF 19.684) Pub Date : 2019-10-25 Ellen F. Carney
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Molecular stratification of idiopathic nephrotic syndrome. Nat. Rev. Nephrol. (IF 19.684) Pub Date : 2019-10-25 Moin A Saleem
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Oncometabolites in renal cancer. Nat. Rev. Nephrol. (IF 19.684) Pub Date : 2019-10-21 Cissy Yong,Grant D Stewart,Christian Frezza
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Immune topology of the human kidney. Nat. Rev. Nephrol. (IF 19.684) Pub Date : 2019-12-01 Susan J Allison
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Artificial intelligence in nephropathology Nat. Rev. Nephrol. (IF 19.684) Pub Date : 2019-10-09 Peter Boor
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Sex and the kidneys: current understanding and research opportunities. Nat. Rev. Nephrol. (IF 19.684) Pub Date : 2019-10-04 C Noel Bairey Merz,Laura M Dember,Julie R Ingelfinger,Amanda Vinson,Joel Neugarten,Kathryn L Sandberg,Jennifer C Sullivan,Christine Maric-Bilkan,Tracy L Rankin,Paul L Kimmel,Robert A Star,
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The multifaceted role of iron in renal health and disease. Nat. Rev. Nephrol. (IF 19.684) Pub Date : 2019-09-25 Rachel P L van Swelm,Jack F M Wetzels,Dorine W Swinkels
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Treating the kidneys - a new era in the United States (and beyond). Nat. Rev. Nephrol. (IF 19.684) Pub Date : 2019-12-01 William H Fissell,Shuvo Roy
Kidney disease is one of the leading causes of death and its prevalence continues to increase worldwide. However, the pace at which new treatments have become available has been excruciatingly slow over the past 30 years. A new White House directive promises to focus the spotlight on accelerating innovations for patients with kidney disease.
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Measured and estimated glomerular filtration rate: current status and future directions Nat. Rev. Nephrol. (IF 19.684) Pub Date : 2019-09-16 Andrew S. Levey, Josef Coresh, Hocine Tighiouart, Tom Greene, Lesley A. Inker
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STING activation by cytoplasmic mtDNA triggers renal inflammation and fibrosis. Nat. Rev. Nephrol. (IF 19.684) Pub Date : 2019-11-01 Susan J Allison
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FGF23 at the crossroads of phosphate, iron economy and erythropoiesis Nat. Rev. Nephrol. (IF 19.684) Pub Date : 2019-09-13 Daniel Edmonston, Myles Wolf
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Prognostic and predictive enrichment in sepsis Nat. Rev. Nephrol. (IF 19.684) Pub Date : 2019-09-11 Natalja L. Stanski, Hector R. Wong
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A new approach to treating renal anaemia. Nat. Rev. Nephrol. (IF 19.684) Pub Date : 2019-12-01 Patrick H Maxwell
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Artificial intelligence to predict AKI: is it a breakthrough? Nat. Rev. Nephrol. (IF 19.684) Pub Date : 2019-11-01 John A Kellum,Azra Bihorac
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The structure of Na+-K+-Cl- cotransporter 1. Nat. Rev. Nephrol. (IF 19.684) Pub Date : 2019-12-01 Alexandre P Garneau,Paul Isenring
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The pathobiology of polycystic kidney disease from a metabolic viewpoint. Nat. Rev. Nephrol. (IF 19.684) Pub Date : 2019-09-05 Luis Fernando Menezes,Gregory G Germino
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Mechanisms of hypoxia signalling: new implications for nephrology. Nat. Rev. Nephrol. (IF 19.684) Pub Date : 2019-09-05 Johannes Schödel,Peter J Ratcliffe
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PAX8: a candidate oncogene in RCC. Nat. Rev. Nephrol. (IF 19.684) Pub Date : 2019-11-01 Susan J Allison
Research Highlight
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Tolerogenic cell therapy for glomerulonephritis. Nat. Rev. Nephrol. (IF 19.684) Pub Date : 2019-11-01 Ellen F Carney
Research Highlight
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Immunology of the ageing kidney. Nat. Rev. Nephrol. (IF 19.684) Pub Date : 2019-09-02 Yuki Sato,Motoko Yanagita
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Disparities between trial cohorts and real-life patients. Nat. Rev. Nephrol. (IF 19.684) Pub Date : 2019-11-01 Andrew Davenport
News & Views
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