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Clinical, Morphologic, and Molecular Features of Benign and Intermediate-grade Melanocytic Tumors With Activating Mutations in MAP2K1. Am. J. Surg. Pathol. (IF 5.6) Pub Date : 2023-09-29 Mónica Fumero-Velázquez, Michael Hagstrom, Soneet Dhillon, Tara Geraminejad, Shantel Olivares, Michele Donati, Daniel Nosek, Pia Waldenbäck, Dmitry Kazakov, Brandon S Sheffield, Victor A Tron, Pedram Gerami
Activating mutations in MAP2K1 can be seen in benign and intermediate-grade melanocytic neoplasms with spitzoid morphology. We analyzed the clinical, histopathologic, and genetic features for 16 cases of benign and intermediate-grade melanocytic tumors harboring activating MAP2K1 mutations. We compared them to Spitz neoplasms with characteristic Spitz fusions or HRAS mutation. We also compared the
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IRF8 in Conjunction With CD123 and CD20 to Distinguish Lupus Erythematosus Panniculitis From Subcutaneous Panniculitis-like T-Cell Lymphoma. Am. J. Surg. Pathol. (IF 5.6) Pub Date : 2023-09-28 Jahg Wong, Simon F Roy, Jennifer M McNiff, Mina L Xu
Distinguishing lupus erythematosus panniculitis (LEP) from subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a diagnostic challenge with important clinical implications. Immunohistochemical expression of interferon regulatory factor 8 (IRF8) has been shown to highlight cells with plasmacytoid dendritic cell differentiation. Considering that the presence of plasmacytoid dendritic cells highlighted
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The Spectrum of HPV-independent Penile Intraepithelial Neoplasia: A Proposal for Subclassification. Am. J. Surg. Pathol. (IF 5.6) Pub Date : 2023-09-28 Sigrid Regauer, Mikhail Ermakov, Karl Kashofer
Compared with vulva, precursor lesions of human papillomavirus (HPV)-independent invasive squamous cell carcinoma (SCC) of the penis are insufficiently characterized. We analyzed the histologic and immunohistochemical characteristics of 70 peritumoral precursor lesions and correlated them with the histology and mutational profile of the adjacent HPV-negative invasive penile SCC. Atypical basal keratinocyte
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Are Metastatic Central Lymph Nodes (D3 volume) in right-sided Colon Cancer a Sign of Systemic Disease? A sub-group Analysis of an Ongoing Multicenter Trial. Ann. Surg. (IF 9.0) Pub Date : 2023-09-27 Gurpreet Singh Banipal, Bojan Vladimir Stimec, Solveig Norheim Andersen, Bjorn Edwin, Jens Marius Nesgaard, Jurate Šaltytė Benth, Dejan Ignjatovic
Assess outcomes of patients with right-sided colon cancer with metastases in the D3 volume after personalized surgery.
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Rate of Emergency Lower Extremity Amputations in the United States among Medicare Beneficiaries. Ann. Surg. (IF 9.0) Pub Date : 2023-09-27 Shukri H A Dualeh, Chloe A Powell, Nicholas Kunnath, Matthew A Corriere, Andrew M Ibrahim
To determine the rate of emergency versus elective lower extremity amputations in the United States.
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Outcomes and Risk Factors for Liver Transplantation Using graft-to-Recipient Weight Ratio Less than 0.8 Graft from Living Donors: Multicentric Cohort Study. Ann. Surg. (IF 9.0) Pub Date : 2023-09-27 Deok-Gie Kim, Shin Hwang, Jong Man Kim, YoungRok Choi, Young Kyoung You, Donglak Choi, Je Ho Ryu, Bong-Wan Kim, Dong-Sik Kim, Jai Young Cho, Man Ki Ju, Tae-Seok Kim, Yang Won Nah, Jae Geun Lee, Myoung Soo Kim, Dong Jin Joo
To compare graft survival after LDLT in patients receiving GRWR<0.8 versus GRWR≥0.8 grafts and identify risk factors for graft loss using GRWR<0.8 grafts.
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TraumaICDBERT, A Natural Language Processing Algorithm to Extract Injury ICD-10 Diagnosis Code from Free Text. Ann. Surg. (IF 9.0) Pub Date : 2023-09-27 Jeff Choi, Yifu Chen, Alexander Sivura, Edward B Vendrow, Jenny Wang, David A Spain
To develop and validate TraumaICDBERT, a natural language processing algorithm to predict injury ICD-10 diagnosis codes from trauma tertiary survey notes.
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An Updated Systematic Review and Meta-Analysis of the Impact of Graduated Compression Stockings in Addition to Pharmacological Thromboprophylaxis for Prevention of Venous Thromboembolism in Surgical Inpatients. Ann. Surg. (IF 9.0) Pub Date : 2023-09-27 Benedict R H Turner, Matthew Machin, Marwah Salih, Sara Jasionowska, Rebecca Lawton, Francesca Siracusa, Adam M Gwozdz, Joseph Shalhoub, Alun H Davies
This systematic review and meta-analysis compares the rate of venous thromboembolism (VTE) in surgical inpatients with pharmacological thromboprophylaxis and additional graduated compression stockings (GCS) versus pharmacological thromboprophylaxis alone.
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Regional Social Vulnerability is Associated with Geographic Disparity in Waitlist Outcomes for Patients with Non-HCC MELD Exceptions in the United States. Ann. Surg. (IF 9.0) Pub Date : 2023-09-27 Robert M Cannon, David S Goldberg, Saulat S Sheikh, Douglas J Anderson, Marcos Pozo, Umaid Rabbani, Jayme E Locke
This study was undertaken to evaluate the role of regional social vulnerability in geographic disparity for patients listed for liver transplant with non-HCC MELD exceptions.
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Evaluating the Impact of Operative Team Familiarity on Cardiac Surgery Outcomes: A Retrospective Cohort Study of Medicare Beneficiaries. Ann. Surg. (IF 9.0) Pub Date : 2023-09-27 Jake A Awtry, James H Abernathy, Xiaoting Wu, Jie Yang, Min Zhang, Hechuan Hou, Tsuyoshi Kaneko, Kim I de la Cruz, Korana Stakich-Alpirez, Steven Yule, Joseph C Cleveland, Douglas C Shook, Michael G Fitzsimons, Steven D Harrington, Francis D Pagani, Donald S Likosky
To associate surgeon-anesthesiologist team familiarity with cardiac surgery outcomes.
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New Sarculator Prognostic Nomograms for Patients with Primary Retroperitoneal Sarcoma: Case Volume Does Matter. Ann. Surg. (IF 9.0) Pub Date : 2023-09-27 Dario Callegaro, Francesco Barretta, Chandrajit P Raut, Wendy Johnston, Dirk C Strauss, Charles Honoré, Sylvie Bonvalot, Mark Fairweather, Piotr Rutkowski, Winan J van Houdt, Rebecca A Gladdy, Fabio Tirotta, Dimitiri Tzanis, Jacek Skoczylas, Rick L Haas, Rosalba Miceli, Carol J Swallow, Alessandro Gronchi
To update the current Sarculator retroperitoneal sarcoma (RPS) prognostic nomograms considering the improvement in patient prognosis and the case volume effect.
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Preoperative Prediction of Postoperative Infections Using Machine Learning and Electronic Health Record Data. Ann. Surg. (IF 9.0) Pub Date : 2023-09-27 Yaxu Zhuang, Adam Dyas, Robert A Meguid, William Henderson, Michael Bronsert, Helen Madsen, Kathryn Colborn
Estimate preoperative risk of postoperative infections using structured electronic health record (EHR) data.
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Circulating Tumor HPV DNA in Patients With Head and Neck Carcinoma: Correlation With HPV Genotyping. Am. J. Surg. Pathol. (IF 5.6) Pub Date : 2023-09-27 Kevin Mijares, Rocco Ferrandino, Raymond Chai, Scott Roof, Swati Bhardwaj, Marshall Posner, William H Westra
Circulating tumor human papillomavirus DNA (ctHPVDNA) testing using digital-droplet polymerase chain reaction (PCR) detects fragments of tumor-modified human papillomavirus (HPV) in the plasma of patients with HPV-associated head and neck squamous cell carcinomas (HNSCCs). Its impact on tumor surveillance and primary diagnosis is limited by unresolved issues relating to sensitivity and specificity
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Changing Patterns in Lung Transplant for Respiratory Failure Due to COVID-19 in the U.S. J. Heart Lung Transplant. (IF 8.9) Pub Date : 2023-09-26 Kemarut Laothamatas, Luke Benvenuto, Frank D’Ovidio, Selim M. Arcasoy
Many patients with severe COVID-19 have been affected by acute respiratory distress syndrome, which has been associated with increased mortality, and up to 31% of these survivors had persistent interstitial lung abnormalities with impaired lung function and quality of life even after 6 to 24 months after initial disease. Lung transplantation quickly emerged as a viable therapy for select patients with
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Papillary Hemangioma Harbors Somatic GNA11 and GNAQ mutations. Am. J. Surg. Pathol. (IF 5.6) Pub Date : 2023-09-26 Catherine K Gestrich, Mathew P Vivero, Dennis J Konczyk, Jeremy A Goss, Brian I Labow, Gregory D Pearson, Catherine E Cottrell, Mariam T Mathew, Vinay Prasad, Harry P Kozakewich, Christopher D M Fletcher, Arin K Greene, Alyaa Al-Ibraheemi
Papillary hemangioma (PH) is a small, primarily dermal lesion occurring predominantly in the head and neck in both children and adults. Its signature characteristics are dilated thin-walled channels containing papillary clusters of mainly capillary-sized vessels and endothelial cytoplasmic eosinophilic inclusions. Given certain histopathologic similarities to congenital hemangioma which harbor mutations
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Information for Readers J. Heart Lung Transplant. (IF 8.9) Pub Date : 2023-09-22
Abstract not available
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Short Postoperative Intravenous Versus Oral Antibacterial Therapy in Complicated Acute Appendicitis - A Pilot Non-Inferiority Randomized Trial. Ann. Surg. (IF 9.0) Pub Date : 2023-09-25 Edgar Lipping, Sten Saar, Arvo Reinsoo, Artjom Bahhir, Ülle Kirsimägi, Urmas Lepner, Peep Talving
The purpose of this study is to investigate noninferiority of postoperative oral administration of antibiotics in complicated appendicitis.
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Malpractice Trends Involving Active Surveillance Across Cancers. Ann. Surg. (IF 9.0) Pub Date : 2023-09-25 Samuel Chang, Timothy J Daskivich, Missael Vasquez, Wendy L Sacks, Zachary S Zumsteg, Allen S Ho
To characterize malpractice trends related to active surveillance (AS) as a treatment strategy across cancers.
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Emergency Department and Inpatient Utilization Reductions and Cost Savings Associated with Trauma Center Mental Health Intervention: Results from a 5-year Longitudinal Randomized Clinical Trial Analysis. Ann. Surg. (IF 9.0) Pub Date : 2023-09-25 Laura Prater, Eileen Bulger, Ronald V Maier, Evan Goldstein, Peter Thomas, Joan Russo, Jin Wang, Allison Engstrom, Khadija Abu, Lauren Whiteside, Tanya Knutzen, Matt Iles-Shih, Patrick Heagerty, Doug Zatzick
The American College of Surgeons Committee on Trauma (ACS/COT) now requires that trauma centers have in place protocols to identify and refer patients at high risk for the psychological sequelae of traumatic injury. No investigations have documented reductions in utilization and associated potential cost savings associated with trauma center mental health interventions.
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Relationship Between Blood and Tissue-Based Rejection-Related Transcripts in Heart Transplantation J. Heart Lung Transplant. (IF 8.9) Pub Date : 2023-09-18 Dae Hyun Lee, Ahsan Usmani, Vani Ravichandran, Tammi Wicks, Robby Wu, Theresa Wolf-Doty, Ioana Dumitru, Peter Berman, Guilherme H. Oliveira, Benjamin Mackie
Purpose The purpose of the study is to investigate the relationship between blood and tissue-derived rejection-related transcripts from blood gene expression profiling (GEP) and molecular microscope in the setting of allograft rejection in heart transplant. Methods All heart transplant patients from August 2021 to May 2022 with both circulating blood GEP (AlloMap; CareDx) and endomyocardial biopsy
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Aortic Root Thrombosis in Patients with HeartMate 3 Left Ventricular Assist Device Support J. Heart Lung Transplant. (IF 8.9) Pub Date : 2023-09-20 Matthew R. Carey, Dylan Marshall, Kevin Clerkin, Ronald Laracuente, Joseph Sanchez, Sneha S. Jain, Jayant K. Raikhelkar, Jay S. Leb, Yuji Kaku, Melana Yuzefpolskaya, Yoshifumi Naka, Paolo C. Colombo, Gabriel T. Sayer, Koji Takeda, Nir Uriel, Veli K. Topkara, Justin A. Fried
Background Aortic root thrombus (ART) formation is a complication of continuous flow left ventricular assist device (LVAD) therapy. However, the incidence and related complications of ART in HeartMate 3 (HM3) patients remains unknown. Methods Patients who underwent HM3 implantation from November 2014 through August 2020 at a quaternary academic medical center were included. Demographics and outcomes
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Spiradenoma With Adenoid Cystic Carcinoma-like Changes: A Case Series of This Rare Variant With a Potential Diagnostic Pitfall. Am. J. Surg. Pathol. (IF 5.6) Pub Date : 2023-09-22 Jose A Plaza, Liubov Kastnerova, Alejandro A Gru, Brittany Dulmage, Martin J Sangueza, Dmitry V Kazakov
Spiradenomas are benign cutaneous adnexal neoplasms with sweat gland differentiation that can manifest a broad spectrum of histomorphologic appearances. While they show a characteristic histopathologic phenotype and clinical management involves surgical excision with a low risk of recurrence, there have been unusual histopathologic variants of spiradenoma reported, including cases with adenoid cystic
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A Novel Type of IDH Wild-type Glioma Characterized by Gliomatosis Cerebri-like Growth Pattern, TERT Promoter Mutation, and Distinct Epigenetic Profile. Am. J. Surg. Pathol. (IF 5.6) Pub Date : 2023-09-22 Amos Muench, Daniel Teichmann, Dorothee Spille, Peter Kuzman, Eilis Perez, Sven-Axel May, Wolf C Mueller, Theodoros Kombos, Shokufe Nazari-Dehkordi, Julia Onken, Peter Vajkoczy, Georgios Ntoulias, Conceição Bettencourt, Andreas von Deimling, Werner Paulus, Frank L Heppner, Arend Koch, David Capper, David Kaul, Christian Thomas, Leonille Schweizer
Diffuse gliomas in adults encompass a heterogenous group of central nervous system neoplasms. In recent years, extensive (epi-)genomic profiling has identified several glioma subgroups characterized by distinct molecular characteristics, most importantly IDH1/2 and histone H3 mutations. A group of 16 diffuse gliomas classified as "adult-type diffuse high-grade glioma, IDH-wildtype, subtype F (HGG-F)"
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International Society of Urological Pathology (ISUP) Consensus Conference on Current Issues in Bladder Cancer: Working Group 3: Subcategorization of T1 Bladder Cancer. Am. J. Surg. Pathol. (IF 5.6) Pub Date : 2023-09-22 Antonio Lopez-Beltran, Maria R Raspollini, Donna Hansel, Eva Compérat, Sean R Williamson, Fredrik Liedberg, Kenneth A Iczkowski, Lukas Bubendorf, Theodorus H van der Kwast, Liang Cheng
Emerging data on T1 bladder cancer subcategorization (aka substaging) suggests a correlation with oncological outcomes. The International Society of Urological Pathology (ISUP) organized the 2022 consensus conference in Basel, Switzerland to focus on current issues in bladder cancer and tasked working group 3 to make recommendations for T1 subcategorization in transurethral bladder resections. For
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Subcutaneous Leiomyosarcoma: An Aggressive Malignancy Portending a Significant Risk of Metastasis and Death. Am. J. Surg. Pathol. (IF 5.6) Pub Date : 2023-09-19 Scott C Bresler, Hailey L Gosnell, Jennifer S Ko, Christina V Angeles, Shira Ronen, Steven D Billings, Rajiv M Patel
Subcutaneous leiomyosarcoma (LMS) is a rare, poorly understood variant. The current literature on the subject is sparse, consisting of isolated case reports and small clinicopathologic studies compromised by the inclusion of both its more common and indolent counterpart, cutaneous LMS (atypical intradermal smooth muscle neoplasm), as well as highly aggressive deep-seated tumors. Thus, precise clinicopathologic
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PRAME Expression Is a Useful Tool in the Diagnosis of Primary and Metastatic Dedifferentiated and Undifferentiated Melanoma. Am. J. Surg. Pathol. (IF 5.6) Pub Date : 2023-09-19 Jason L Hornick, Jose A Plaza, Thomas Mentzel, Alejandro A Gru, Thomas Brenn
Although mostly recognized in the metastatic setting dedifferentiated and undifferentiated melanomas are increasingly recognized as cutaneous and, less commonly, mucosal primary tumors. Their diagnosis is challenging and dependent on sampling and recognition of a conventional melanoma precursor and/or detection of a mutation in a conventional melanoma driver gene. PRAME immunohistochemistry has recently
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Perioperative Extracorporeal Membrane Oxygenation Support for Pulmonary Endarterectomy: A 17-year Experience from the UK National Cohort J. Heart Lung Transplant. (IF 8.9) Pub Date : 2023-09-18 Alicia X.F. CHIA, Kamen VALCHANOV, Choo NG, Steven TSUI, John TAGHAVI, Alain VUYLSTEKE, Jo-anne FOWLES, David P. JENKINS
Background Pulmonary endarterectomy(PEA) is the guideline recommended treatment for patients with chronic thromboembolic pulmonary hypertension(CTEPH). However, some patients develop severe cardiopulmonary compromise either prior to surgery, intraoperatively or early postoperatively. This may result from advanced CTEPH, reperfusion pulmonary oedema, massive endobronchial bleeding or right ventricular(RV)
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Acute Rejection In Donation After Circulatory Death (DCD) Heart Transplants J. Heart Lung Transplant. (IF 8.9) Pub Date : 2023-09-17 Selena S. Li, Masaki Funamoto, Asishana A. Osho, Seyed A. Rabi, Dane Paneitz, Ruby Singh, Eriberto Michel, Gregory D. Lewis, David A. D’Alessandro
Background Donation after circulatory death (DCD) heart transplantation has promising early survival, but effects on rejection remain unclear. Methods The United Network for Organ Sharing (UNOS) database was queried for adult heart transplants from 12/01/2019 to 12/31/2021. Multiorgan transplants and loss to follow-up were excluded. Primary outcome was acute rejection, comparing DCD and donation after
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COVID-19 outcomes in heart transplant recipients: a large Australian cohort. J. Heart Lung Transplant. (IF 8.9) Pub Date : 2023-09-14 C Cherrett, J Cao, C Adams, PS Macdonald
Heart transplant recipients have been reported to be at a significantly elevated risk of poor outcomes from COVID-19 infection owing to their underlying comorbidities and immunosuppression. We conducted a single-centre retrospective cohort of all heart transplant recipients who were known to have contracted COVID-19 between January 2020 to September 2022. Electronic medical records were used to collect
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Cardiac Allograft Vasculopathy and Survival in Pediatric Heart Transplant Recipients Transitioned to Adult Care J. Heart Lung Transplant. (IF 8.9) Pub Date : 2023-09-11 Eduard Rodenas-Alesina, Natasha Aleksova, Michael Stubbs, Farid Foroutan, Stella Kozuszko, Juan Duero Posada, Michael McDonald, Yasbanoo Moayedi, Heather Ross, Anne Dipchand
Background Cardiac allograft vasculopathy (CAV) is an important cause of mortality after pediatric heart transplantation (HT) but there is a paucity of data regarding its incidence and impact on survival in pediatric recipients transitioned to adult care. Methods We conducted a retrospective review of consecutive pediatric HT patients from 1989-2017 at the Hospital for Sick Children who transitioned
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Living-Donor Lobar Lung Transplantation J. Heart Lung Transplant. (IF 8.9) Pub Date : 2023-09-11 Hiroshi Date
Living-donor lobar lung transplantation (LDLLT) is indicated for critically ill patients who would not survive the waiting period in the case of severe brain-dead donor shortage. It is essential to confirm that potential donors are willing to donate without applying psychological pressure from others. In standard LDLLT, the right and left lower lobes donated by two healthy donors are implanted into
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Incidence and Clinicopathologic Characteristics of Human Papillomavirus-independent Invasive Squamous Cell Carcinomas of the Cervix: A Morphologic, Immunohistochemical, and Human Papilloma-Virologic Study of 670 Cases. Am. J. Surg. Pathol. (IF 5.6) Pub Date : 2023-09-13 Simona Stolnicu, Douglas Allison, Aaron M Praiss, Basile Tessier-Cloutier, Amir Momeni Boroujeni, Jessica Flynn, Alexia Iasonos, Rene Serrette, Lien Hoang, Andrei Patrichi, Cristina Terinte, Anna Pesci, Claudia Mateoiu, Ricardo R Lastra, Takako Kiyokawa, Rouba Ali-Fehmi, Mira Kheil, Esther Oliva, Kyle M Devins, Nadeem R Abu-Rustum, Robert A Soslow
We aimed to determine the frequency of human papillomavirus-independent (HPVI) cervical squamous cell carcinoma (SCC) and to describe clinicopathologic characteristics. Among 670 patients with surgically treated SCCs in an established multi-institutional cohort, 447 had available tissue. Tissue microarrays were constructed and studied by in situ hybridization (ISH) for high-risk and low-risk human
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2 days versus 5 days of Postoperative Antibiotics for Complex Appendicitis: Cost Analysis of a Randomized, Non-inferiority Trial. Ann. Surg. (IF 9.0) Pub Date : 2023-09-12 Elisabeth M L de Wijkerslooth, Evert-Jan G Boerma, Charles C van Rossem, Marc A Koopmanschap, Coen I M Baeten, Frédérique H Beverdam, Joanna W A M Bosmans, Esther C J Consten, Jan Willem T Dekker, Marloes Emous, Anna A W van Geloven, Anton F Gijsen, Luc A Heijnen, An P Jairam, Augustinus P T van der Ploeg, Pascal Steenvoorde, Boudewijn R Toorenvliet, Maarten Vermaas, Bas Wiering, Bas P L Wijnhoven
To compare costs for 2 days versus 5 days of postoperative antibiotics within the Antibiotics following aPPendectomy In Complex appendicitis (APPIC) trial.Summary Background Data:Recent studies suggest that restrictive antibiotic use leads to a significant reduction in hospital stay without compromising patient safety. Its potential effect on societal costs remains underexplored.
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The central role of ubiquitin-specific protease 8 in leptin signaling pathway in pulmonary arterial hypertension J. Heart Lung Transplant. (IF 8.9) Pub Date : 2023-09-11 Etienne-Marie JUTANT, Mustapha K. CHELGHAM, Mina OTTAVIANI, Raphaël THUILLET, Benjamin LE VELY, Marc HUMBERT, Christophe GUIGNABERT, TU Ly, Alice HUERTAS
Aims Leptin receptor (ObR-b) is overexpressed in pulmonary artery smooth muscle cells (PA-SMCs) from pulmonary arterial hypertension (PAH) patients and is implicated in both mechanisms that contribute to pulmonary vascular remodeling: hyperproliferation and inflammation. Our aim was to investigate the role of ubiquitin-specific peptidase 8 (USP8) in ObR-b overexpression in PAH. Methods and Results
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Comprehensive Clinical-Pathologic Assessment of Malignant Phyllodes Tumors: Proposing Refined Diagnostic Criteria. Am. J. Surg. Pathol. (IF 5.6) Pub Date : 2023-09-11 Gulisa Turashvili, Qingqing Ding, Yi Liu, Limin Peng, Miralem Mrkonjic, Haider Mejbel, Yihong Wang, Huina Zhang, Gloria Zhang, Jigang Wang, Shi Wei, Xiaoxian Li
The latest World Health Organization classification of breast tumors recommends diagnosing malignant phyllodes tumors (MPTs) when all 5 morphologic features are present: permeative borders, marked stromal cellularity, marked stromal cytologic atypia, ≥10 mitoses per 10 high-power fields (HPF), and stromal overgrowth. We assessed the performance of this recommendation to capture MPTs and features predictive
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Critical Appraisal of Histologic Grading for Mucoepidermoid Carcinoma of Salivary Gland: Is an Objective Prognostic 2-tiered Grading System Possible? Am. J. Surg. Pathol. (IF 5.6) Pub Date : 2023-09-11 Bin Xu, Bayan Alzumaili, Karina C Furlan, German H Martinez, Marc Cohen, Ian Ganly, Ronald A Ghossein, Nora Katabi
Multiple 3-tiered grading systems exist for mucoepidermoid carcinoma (MEC), leading to controversial results on the frequency and prognostic values of each grade. We aimed to identify prognostic histologic factors and to evaluate grading schemes in this retrospective study of 262 resected primary head and neck MECs. The rate of nodal metastasis was 8.4%. Large tumor size, tumor fibrosis, infiltrative
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Early Detection of Cardiac Allograft Vasculopathy: Searching for a Better Beginning? J. Heart Lung Transplant. (IF 8.9) Pub Date : 2023-09-09 Jaime A. Hernandez-Montfort
Abstract not available
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Not little adults - outcomes in pediatric intra-corporeal LVAD patients J. Heart Lung Transplant. (IF 8.9) Pub Date : 2023-09-06 Martin Schweiger, Oliver Miera
Abstract not available
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Cerebral Blood Flow After Thoracoabdominal Normothermic Regional Perfusion: Fundamental Yet Underexplored J. Heart Lung Transplant. (IF 8.9) Pub Date : 2023-09-06 Christos Lazaridis
Abstract not available
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Surveillance of Individuals at High Risk of Developing Pancreatic Cancer: A Prevalence meta-analysis to Estimate the Rate of low-yield Surgery. Ann. Surg. (IF 9.0) Pub Date : 2023-09-08 Salvatore Paiella, Erica Secchettin, Gabriella Lionetto, Livia Archibugi, Danila Azzolina, Fabio Casciani, Diane M Simeone, Kasper A Overbeek, Michael Goggins, James Farrell, Ruggero Ponz de Leon Pisani, Maddalena Tridenti, Maria Assunta Corciulo, Giuseppe Malleo, Paolo Giorgio Arcidiacono, Massimo Falconi, Dario Gregori, Claudio Bassi, Roberto Salvia, Gabriele Capurso
To quantify the rate of low-yield surgery, defined as no high-grade dysplastic precursor lesions or T1N0M0 pancreatic cancer at pathology, during pancreatic cancer surveillance.
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Infantile Sinonasal Myxoma Is Clinically and Genetically Distinct From Other Myxomas of the Craniofacial Bones and From Desmoid Fibromatosis. Am. J. Surg. Pathol. (IF 5.6) Pub Date : 2023-09-07 Igor Odintsov, Fei Dong, Jeffrey P Guenette, Karen J Fritchie, Vickie Y Jo, Christopher D M Fletcher, David J Papke
Sinonasal myxomas are rare benign tumors of the maxillary bone and sinus. There is published evidence that sinonasal myxomas occurring in children up to 3 years of age ("infantile sinonasal myxomas") are clinically distinctive and harbor Wnt signaling pathway alterations. Here, we characterized 16 infantile sinonasal myxomas and compared them to 19 maxillary myxomas and 11 mandibular myxomas in older
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Extracorporeal driveline vibrations to detect left ventricular assist device thrombosis – a porcine model study J. Heart Lung Transplant. (IF 8.9) Pub Date : 2023-09-04 Didrik Lilja, Itai Schalit, Andreas Espinoza, Tom Nilsen Hoel, Guttorm Larsen, Fred-Johan Pettersen, Per Steinar Halvorsen
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Treatment of Staphylococcus aureus infection with sphingosine in ex vivo perfused and ventilated lungs J. Heart Lung Transplant. (IF 8.9) Pub Date : 2023-09-04 Yongjie Liu, Yuqing Wu, Lydia Leukers, Kristin Schimank, Jonathan Wilker, Andreas Wissmann, Ursula Rauen, Nikolaus Pizanis, Christian Taube, Achim Koch, Erich Gulbins, Markus Kamler
Background Ex vivo lung perfusion (EVLP) has expanded the donor pool for lung transplantation. Pulmonary Staphylococcus aureus infection, especially that caused by multidrug resistant strains, is a severe threat to post-transplantation outcomes. Sphingosine is a lipid compound that exhibits broad-spectrum antibacterial activity. Therefore, we aimed to evaluate the effects of S. aureus infection on
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Unlocking LVAD Access: A Fresh Outlook on Social Support J. Heart Lung Transplant. (IF 8.9) Pub Date : 2023-09-03 Maya Guglin
Abstract not available
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How Does Omitting Additional Surgery after Local Excision Affect the Prognostic Outcome of Patients with High-risk T1 Colorectal Cancer? Ann. Surg. (IF 9.0) Pub Date : 2023-09-05 Akira Ouchi, Koji Komori, Tajika Masahiro, Kazuhiro Toriyama, Yoshiki Kajiwara, Shiro Oka, Yosuke Fukunaga, Kinichi Hotta, Hiroaki Ikematsu, Shunsuke Tsukamoto, Shinji Nagata, Kazutaka Yamada, Maki Konno, Soichiro Ishihara, Yusuke Saitoh, Kenji Matsuda, Kazutomo Togashi, Megumi Ishiguro, Toshio Kuwai, Takashi Okuyama, Akihiro Ohuchi, Shinobu Ohnuma, Kazuhiro Sakamoto, Tamotsu Sugai, Kenji Katsumata
To investigate how omitting additional surgery after local excision (LE) affects patient outcomes in high-risk T1 colorectal cancer (CRC).
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Negotiated Rates for Surgical Cancer Care in the Era of Price Transparency-Prices Reflect Market Competition. Ann. Surg. (IF 9.0) Pub Date : 2023-09-04 Danielle H Rochlin, Nada M Rizk, Evan Matros, Todd H Wagner, Clifford C Sheckter
To measure commercial price variation for cancer surgery within and across hospitals.
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Short Airway Telomeres are Associated with Primary Graft Dysfunction and Chronic Lung Allograft Dysfunction J. Heart Lung Transplant. (IF 8.9) Pub Date : 2023-08-28 John R Greenland, Ruyin Guo, Seoyeon Lee, Lily Tran, Bhavya Kapse, Jasleen Kukreja, Steven R Hays, Jeffrey A Golden, Daniel R Calabrese, Jonathan P Singer, Paul J Wolters
Primary graft dysfunction (PGD) is a major risk factor for chronic lung allograft dysfunction (CLAD) following lung transplantation, but the mechanisms linking these pathologies are poorly understood. We hypothesized that the replicative stress induced by PGD would lead to erosion of telomeres, and that this telomere dysfunction could potentiate CLAD. In a longitudinal cohort of 72 lung transplant
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Impact of Community Socioeconomic Distress on Survival Following Heart Transplantation. Ann. Surg. (IF 9.0) Pub Date : 2023-08-29 Sara Sakowitz, Syed Shahyan Bakhtiyar, Saad Mallick, Joanna Curry, Nameer Ascandar, Peyman Benharash
To assess the impact of community-level socioeconomic deprivation on survival outcomes following heart transplantation.
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Quality of Life and Real-Time Patient Experience During Neoadjuvant Therapy: A Prospective Cohort Study. Ann. Surg. (IF 9.0) Pub Date : 2023-08-29 Alexander H Shannon, Angela Sarna, Luke Bressler, Christina Monsour, Marilly Palettas, Emily Huang, Desmond M D'Souza, Peter J Kneuertz, Aslam Ejaz, Timothy M Pawlik, Heena Santry, Jordan M Cloyd
Neoadjuvant therapy (NT) is increasingly used for patients with localized gastrointestinal (GI) cancers. There is little data assessing patient experience and quality of life (QOL) during NT for GI cancers.
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Safety, Efficacy, and Cost-effectiveness of Outpatient Surgery for Uncomplicated Acute Appendicitis. The PENDI-CSI Randomized Clinical Trial. Ann. Surg. (IF 9.0) Pub Date : 2023-08-29 Virgina Durán Muñoz-Cruzado, Laura Navarro Morales, Felipe Pareja Ciuró, Daniel Aparicio Sánchez, Luis Tallón Aguilar, Javier Padillo-Ruiz
To evaluate the safety, efficacy, and cost-effectiveness of outpatient appendectomy in patients with uncomplicated acute appendicitis.
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Non-Neoplastic Thoracic Cysts: A Clinicopathologic Study of 136 Cases. Am. J. Surg. Pathol. (IF 5.6) Pub Date : 2023-08-29 Annikka Weissferdt
Benign cysts of the thoracic cavity represent a group of rare lesions, the spectrum of which is expanding. Most of these are congenital in nature, secondary to abnormal development during embryogenesis while a smaller subset represents acquired lesions. We retrospectively reviewed the clinicopathologic features of 136 patients with thoracic cysts that were treated in our institution over a span of
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Increased disparities in waitlist and post-heart transplantation outcomes according to socioeconomic status with the new heart transplant allocation system J. Heart Lung Transplant. (IF 8.9) Pub Date : 2023-08-27 Catherine E. Kelty, Michael Dickinson, Marzia Leacche, Milena Jani, Nabin K. Shrestha, Sangjin Lee, Deepak Acharya, Indranee Rajapreyar, Richard C. Sadler, Erin McNeely, Renzo Loyaga-Rendon
Background The study objective was to assess disparities in outcomes in the waitlist and post-heart transplantation (HT) according to socioeconomic status (SES) in the old and new U.S. HT allocation systems. Methods Adult HT candidates in the UNOS database from 2014 through 2021 were included. Old or new system classification was according to listing before or after October 18, 2018. SES was stratified
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Characteristics and Outcomes of Lung Transplants Performed with Ex-situ Lung Perfusion J. Heart Lung Transplant. (IF 8.9) Pub Date : 2023-08-27 Yu Xia, Samuel T. Kim, Michael Dacey, David Sayah, Reshma Biniwale, Abbas Ardehali
Background Ex-situ lung perfusion (ESLP) can be used to assess and rehabilitate donor lungs, potentially expanding the donor pool. We examined the characteristics and outcomes of lung transplants performed with ESLP in the United States. Methods Retrospective review of the United Network for Organ Sharing (UNOS) registry of primary adult lung transplant recipients from February 28, 2018 to June 30
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Surgery for fibrosing mediastinitis with severe pulmonary hypertension due to pulmonary venous stenosis J. Heart Lung Transplant. (IF 8.9) Pub Date : 2023-08-26 Jing-Ren Ye, Szu-Yen Hu, Yen-Hung Lin, Chi-Hsiang Huang, Hsao-Hsun Hsu, Shu-Chien Huang
A 21-year-old woman with severe pulmonary hypertension and circulatory collapse was referred to our hospital for possible lung transplantation with extracorporeal membrane oxygenation support. Computed tomography revealed severe stenosis of all four pulmonary veins, and fibrosing mediastinitis was suspected. Surgical reconstruction of the pulmonary veins was performed, and extracorporeal membrane oxygenation
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Favorable effect of CD26/DPP-4 inhibitors on postoperative outcomes after lung transplantation: a propensity-weighted analysis J. Heart Lung Transplant. (IF 8.9) Pub Date : 2023-08-25 Yoshito Yamada, Tosiya Sato, Hiromi Oda, Norio Harada, Akihiko Yoshizawa, Shigeto Nishikawa, Hidenao Kayawake, Satona Tanaka, Yojiro Yutaka, Masatsugu Hamaji, Daisuke Nakajima, Akihiro Ohsumi, Hiroshi Date
Background We have shown the efficacy of CD26/dipeptidyl peptidase 4 (CD26/DPP-4) inhibitors, antidiabetic agents, in allograft protection after experimental lung transplantation (LTx). We aimed to elucidate whether CD26/DPP-4 inhibitors effectively improve postoperative outcomes after clinical LTx. Methods We retrospectively reviewed the records of patients undergoing LTx at our institution between
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Host CD34+ Cells Are Replacing Donor Endothelium of Transplanted Heart J. Heart Lung Transplant. (IF 8.9) Pub Date : 2023-08-25 Ting Chen, Xiaotong Sun, Hui Gong, Mengjia Chen, Yaning Li, Ting Wang, Xueyin Huang, Zuoshi Wen, Jianing Xue, Peng Teng, Yanhua Hu, Li Zhang, Jun Yang, Qingbo Xu, Weidong Li
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The Reality of DCD Donor Use in Pediatric Thoracic Transplantation in The United States J. Heart Lung Transplant. (IF 8.9) Pub Date : 2023-08-22 Hosam F. Ahmed, Amalia Guzman-Gomez, Kevin Kulshrestha, Eashwar C. Kantemneni, Clifford Chin, Awais Ashfaq, Farhan Zafar, David L.S. Morales
In the US, the first pediatric donation after circulatory death (DCD) thoracic transplant was done in 2004; however, ethical controversy led to minimal utilization of these donors. The present study was performed to characterize the current state of pediatric DCD heart and lung transplantation (HTx, LTx). Children (<18yo) who underwent HTx or LTx using DCD donors from June 2004-June 2022 were identified
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CT-derived Lung Vessel Morphology Correlates with Prognostic Markers in Pre-capillary Pulmonary Hypertension J. Heart Lung Transplant. (IF 8.9) Pub Date : 2023-08-22 Michael Pienn, Roman J. Gertz, Felix Gerhardt, Jan R. Kröger, Hasan Zaytoun, Robert P. Reimer, Anil Kaplan, Max Wissmüller, Gabor Kovacs, Stephan Rosenkranz, Horst Olschewski, Alexander C. Bunck
Background While computed tomography pulmonary angiography (CTPA) is an integral part of the work-up in patients with suspected pulmonary hypertension (PH), there is no established CTPA-derived prognostic marker. We aimed to assess whether quantitative readouts of lung vessel morphology correlate with established prognostic indicators in PH. Methods We applied a fully-automatic in-house developed algorithm