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From Flawed to Fairer: Reducing Blood Type Bias in Lung Transplant Allocation. Am. J. Transplant. (IF 8.9) Pub Date : 2025-02-13 Isaac S Alderete,Matthew G Hartwig
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An Ethical Framework for Cost-Conscious Surgical Practice. Ann. Surg. (IF 7.5) Pub Date : 2025-02-13 Hannah M Phelps,Sean C Wightman,Baddr A Shakhsheer
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MEsh FIxation STudy in Laparoendoscopic Repair of M3 Inguinal Hernias: multicenter, double-blind, randomized controlled trial - MEFISTO Trial. Ann. Surg. (IF 7.5) Pub Date : 2025-02-13 Mateusz Zamkowski,Śmietański Maciej,Franczak Paula,Górski Dominik,Grabias Jacek,Janik Michał,Król Aleksander,Mitura Kryspin,Mędraś Olaf,Nawacki Łukasz,Romańczuk Michał,Rymkiewicz Przemysław,Saluk Sławomir,Sroczyński Przemysław,Sułkowski Leszek,Wieczorek Dominik,Włodarczyk Marcin
OBJECTIVE To evaluate the efficacy of non-fixation versus fixation of meshes in laparoendoscopic repair of M3 inguinal hernias in terms of recurrence, postoperative pain, and surgical complications. SUMMARY BACKGROUND DATA International guidelines recommend mesh fixation for large M3 inguinal hernias during laparoendoscopic repairs due to high recurrence rates. However, emerging experimental and registry
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Influence of the Surgeon's First Operation of the Day on Patient Outcomes. Ann. Surg. (IF 7.5) Pub Date : 2025-02-13 Filippo Dagnino,Tephanie Polazzi,Jean-Christophe Lifante,Tanujit Dey,Antoine Duclos,
OBJECTIVE To investigate whether the cumulative operative time spent by a surgeon operating on patients on the same day prior to starting a new procedure was associated with surgical outcomes. BACKGROUND The impact of daily operating room workload on a surgeon's performance and patient outcomes is uncertain. METHODS All elective patients, operated by attending surgeons across seven specialties in four
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Baicalein relieves lung graft ischemia-reperfusion injury by reducing advanced glycation endproducts: From screens to mechanisms. J. Heart Lung Transplant. (IF 6.4) Pub Date : 2025-02-13 Dong Tian,Xiang-Yun Zheng,Sen-Lin Hou,Zeng-Wei Yu,Ye Wu,Pei-Zhi Liu,Lin-Xi Liu,Yu-Xuan Chen,Yang Zhao,Yang Li,Hong-Tao Tang,Wei-Yang Chen,Ya-Ling Liu,Chuan-Fen Zhang,Yun Wang,Hong-Ying Wen,Qiang Pu,Masaaki Sato,Lun-Xu Liu
BACKGROUND The lack of effective drugs for treating ischemia-reperfusion injury (IRI) in lung transplants (LTx) remains an issue. Traditional Chinese medicine (TCM) ingredients are promising but poorly studied in LTx. This study aimed to identify potential ingredients and elucidate their mechanisms. METHODS Ten TCM ingredients, including (-)-epigallocatechin-3-gallate, quercetin, wogonin, triptolide
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Rediscovering the Clitoris-Sexual Function After Transvaginal Surgery. JAMA Surg. (IF 15.7) Pub Date : 2025-02-12 Neha G Gaddam,Bayley E Clarke,Cheryl B Iglesia
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Postoperative Sexual Function After Vaginal Surgery and Clitoral Size, Position, and Shape. JAMA Surg. (IF 15.7) Pub Date : 2025-02-12 Shaniel T Bowen,Pamela A Moalli,Rebecca G Rogers,Marlene M Corton,Uduak U Andy,Charles R Rardin,Michael E Hahn,Alison C Weidner,David R Ellington,Donna Mazloomdoost,Amaanti Sridhar,Marie G Gantz,
Importance Transvaginal surgery is commonly performed to treat pelvic organ prolapse. Little research focuses on how sexual function relates to clitoral anatomy after vaginal surgery despite the clitoris' role in the sexual response. Objective To determine how postoperative sexual function after vaginal surgery is associated with clitoral features (size, position, shape). Design, Setting, and Participants
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Quantifying Social Vulnerability and Its Impact on Health Care Delivery, Payment, and Performance JAMA Surg. (IF 15.7) Pub Date : 2025-02-12 Lisa M. McElroy, Caroline P. Thirukumaran, Catherine G. Velopulos
This Viewpoint advocates for the inclusion of social determinants of health and health-related social needs data into the electronic health record as a measure for improving provision of equitable surgical care.
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Management of Perforated Peptic Ulcer JAMA Surg. (IF 15.7) Pub Date : 2025-02-12 Seyed A. Arshad, Patrick Murphy, Jon C. Gould
ImportancePerforated peptic ulcer disease (PUD) affects 4 million people annually worldwide, with a lifetime prevalence of 5% to 10%. Of those affected, 5% will progress to the point of perforation. Despite advances in the understanding and treatment, perforated PUD continues to have a high rate of morbidity (50%) and mortality (30%). This review summarizes the current evidence on management of perforated
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The Role of High-Resolution Manometry Before and Following Antireflux Surgery: The Padova Consensus: Erratum. Ann. Surg. (IF 7.5) Pub Date : 2025-02-12
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The Relevance of Optimal Preoperative Glycemic Control for Outcomes of Patients with Diabetes Undergoing Surgery. Ann. Surg. (IF 7.5) Pub Date : 2025-02-12 Adriana C Panayi,Samuel Knoedler,Michael Alfertshofer,Dany Y Matar,Sarah Friedrich,Jasmin Rühl,Valentin Haug,Emre Gazyakan,Amir Khosrow Bigdeli,Ulrich Kneser,Dennis P Orgill,Gabriel Hundeshagen
OBJECTIVE To investigate the association between glycemic control, measured by glycated hemoglobin (HbA1c) levels, and post-operative complications across various procedures, identify the prevalence of patients with undiagnosed prediabetes or diabetes undergoing surgery, and explore whether better glycemic management is associated with reduced short-term postoperative complications. BACKGROUND The
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Living donor lobar lung transplantation in children: an impressive Japanese cohort and worldwide implications. J. Heart Lung Transplant. (IF 6.4) Pub Date : 2025-02-12 Nicholas Avdimiretz,Christian Benden
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In Memoriam - Professor Allan R Glanville, Past President ISHLT. J. Heart Lung Transplant. (IF 6.4) Pub Date : 2025-02-12 Peter Mark Anthony Hopkins
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Does a Changing Donor Pool Explain the Recent Rise in U.S. Kidney Non-Use Rate? Am. J. Transplant. (IF 8.9) Pub Date : 2025-02-11 Keighly Bradbrook,David Klassen,Allan B Massie,Darren E Stewart
The proportion of deceased donor kidneys recovered for transplantation that are not transplanted reached 28% in 2023. Past research demonstrated that >90% of the non-use rate increase in the 2000s could be explained by the broadening donor pool. We used OPTN data to study kidneys recovered 2010-2023, applying causal inference methods to assess the degree to which the recent, sharp rise in the non-use
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Evolving Epidemiology of Increasing Trauma Deaths in the UNITED STATES (2000-2020). Ann. Surg. (IF 7.5) Pub Date : 2025-02-11 Peter Rhee,John B Holcomb,Bardiya Zangbar
BACKGROUND Over the past two decades, the epidemiology of trauma has shifted significantly, driven primarily by demographic changes. Aim of our study was to illustrate the changing landscape of trauma mortality rates and compare them with other leading causes of death. METHODS We performed a cross-sectional study from 2000-2020, using data from the CDC and WISQARS™. Trauma deaths were defined according
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Right ventricular-pulmonary arterial coupling in schistosomiasis associated pulmonary arterial hypertension. J. Heart Lung Transplant. (IF 6.4) Pub Date : 2025-02-11 Jose Leonidas Alves-Jr,Eduardo Leite Vieira Costa,Susana Hoette,Caio Julio Cesar Dos Santos Fernandes,Henrique Barbosa Ribeiro,Alexandre Antonio Cunha Abizaid,Marcela Araújo Castro,Bruna Mamprim Piloto,Pedro Alves Lemos,Carlos Viana Poyares Jardim,Ryan J Tedford,Rogerio Souza
BACKGROUND Schistosomiasis associated pulmonary arterial hypertension (Sch-PAH) is a highly relevant form of pulmonary hypertension, particularly in developing countries. Compared with idiopathic pulmonary arterial hypertension (IPAH), Sch-PAH has a better prognosis, though without identified mechanisms that justify this clinical course. Right ventricular-arterial pulmonary (RV-PA) coupling, expressed
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Durable left ventricular assist device in donation after circulatory death heart transplantation. J. Heart Lung Transplant. (IF 6.4) Pub Date : 2025-02-11 Yeahwa Hong,Umar Nasim,Nidhi Iyanna,Ander Dorken-Gallastegi,Mary E Keebler,Edward T Horn,Gavin W Hickey,David J Kaczorowski
BACKGROUND This study evaluates outcomes following donation after circulatory death (DCD) heart transplantation in recipients with a durable left ventricular assist device (LVAD). METHODS UNOS registry was queried to analyze adult recipients of isolated DCD heart transplantation between 1/1/2019-3/31/2023. The recipients were stratified by durable LVAD use as a bridge to transplantation. The primary
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Cost-analysis of Implementing robot-assisted Versus Open Pancreatoduodenectomy. Ann. Surg. (IF 7.5) Pub Date : 2025-02-10 Julia E Menso,Michiel F G Francken,Nine de Graaf,Alessandro M Bonomi,Riccardo Guastella,Dylan Balaban,Mahsoem Ali,H Jaap Bonjer,Susan van Dieren,Marcel G W Dijkgraaf,Jony van Hilst,Gabriela Pilz da Cunha,Joris Erdmann,Geert Kazemier,Rutger-Jan Swijnenburg,Barbara M Zonderhuis,Freek Daams,Sebastiaan Festen,Olivier R Busch,Marc G Besselink,
OBJECTIVE To perform a cost-analysis during the implementation of robot-assisted pancreatoduodenectomy (RPD) in a high-volume center. BACKGROUND Many high-volume centers are implementing RPD as alternative to open pancreatoduodenectomy (OPD) but the persevering concerns about increased costs of RPD versus OPD have not been addressed by large studies. METHODS Post-hoc cost-analysis of consecutive RPD
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Recurrence Following Operative vs. Non-Operative Management of Adhesive Small Bowel Obstruction in Children: A Multi-center Prospective Observational Study. Ann. Surg. (IF 7.5) Pub Date : 2025-02-10 Utsav M Patwardhan,Romeo C Ignacio,Kaci Pickett-Nairne,Katie W Russell,Justin Lee,Ben Padilla,Caroline Melhado,Lorraine I Kelley-Quon,David H Rothstein,Hariharan Thangarajah,Ana Ibarra-Meraz,Rabab M Barq,Kezlyn E Larsen,Kathryn L Fowler,Zebediah Hunteman,Maria Valencia-Bradd,Katrine Lofberg,Aaron Jensen,Samir Pandya,Shannon N Acker,
OBJECTIVE Data on the incidence of recurrent adhesive small bowel obstruction (ASBO) following index admission for ASBO in children are limited. We sought to determine if operative management was associated with a lower rate of recurrence compared to non-operative management (NOM). METHODS We conducted a prospective observational study of children with ASBO admitted to nine hospitals from 10/2020 to
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Predictors of Neurodevelopmental Impairment After Intestinal Resection for Necrotizing Enterocolitis: A Multicenter Retrospective Study. Ann. Surg. (IF 7.5) Pub Date : 2025-02-10 Utsav M Patwardhan,Alex Gonzalez,Insiyah Campwala,Erin E West,Madeline Goldfarb,Daniel B Gehle,Lauren Camp,Krishna Manohar,Brooke E Allen,Mary E Moya-Mendez,Isabel DeLaura,Kathryn Maselli,Grant Gershner,Alena Golubkova,Georgi Mladenov,Amanda Witte,Gabriella Grisotti,Troy A Markel,Rebeccah L Brown,Henry E Rice,Jose H Salazar,Catherine J Hunter,Tim Jancelewicz,Samir Gadepalli,Andrei Radulescu,Paul Waltz
OBJECTIVE The aim of this study was to evaluate pre-resection risk factors for neurodevelopmental impairment (NDI) in infants with necrotizing enterocolitis (NEC) that might better inform the timing of intestinal resection. SUMMARY BACKGROUND DATA Surgical NEC is associated with a 57% risk for NDI. METHODS A retrospective study of patients with NEC who underwent intestinal resection within 10 days
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The Association Between Surgical Margin Status, Recurrence Patterns, and Oncologic Outcomes in Patients with Colorectal Liver Metastases. Ann. Surg. (IF 7.5) Pub Date : 2025-02-10 Thomas Perrin,Sarah M McIntyre,Fiona Ehrich,Jon Heiselman,Eric P van der Stok,Megan Fiasconaro,Mithat Gönen,Jinru Shia,T Peter Kingham,Vinod P Balachandran,Jeffrey A Drebin,Alice C Wei,William R Jarnagin,Michael I D'Angelica
OBJECTIVE To enhance understanding of the relationships between margin width, recurrence patterns, recurrence-free survival, and salvage therapy following initial hepatectomy for colorectal liver metastases (CRLM). BACKGROUND The prognostic implications of the technical aspects of CRLM have not been well-characterized. METHODS A prospective database of 1776 patients who underwent complete resection
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Temporary Portal Vein Bypass for Resection of Pancreatic Neoplasms. Ann. Surg. (IF 7.5) Pub Date : 2025-02-10 Max Heckler,Souhaylah Abdallah,Benedict Kinny-Köster,Christoph Berchtold,Mohammed Al-Saeedi,Arianeb Mehrabi,Thilo Hackert,Ulf Hinz,Thomas Hank,Christoph W Michalski,Markus W Büchler,Martin Loos
OBJECTIVE We analyzed perioperative outcomes of patients undergoing pancreatectomy with portal vein resection for pancreatic cancer using temporary intraoperative mesoportal or mesocaval bypass. SUMMARY BACKGROUND DATA Pancreatectomy for advanced pancreatic cancer with long-segment involvement or complete occlusion of the mesoportal venous axis and cavernous transformation represents a major technical
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The Steep Cliff of Renal Failure after Heart Transplant: Is a Safety Net Enough to Rescue Those Who Fall? J. Heart Lung Transplant. (IF 6.4) Pub Date : 2025-02-10 Amrut V Ambardekar,Laura L Peters
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Reply to: Comment on "Immunomodulatory soluble HLA-G and HLA-E are associated with rapidly deteriorating CLAD and HCMV viremia after lung transplantation". J. Heart Lung Transplant. (IF 6.4) Pub Date : 2025-02-10 Hannes Vietzen
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Octo- and nonagenarian donors in lung transplantation: a dual center experience. J. Heart Lung Transplant. (IF 6.4) Pub Date : 2025-02-10 Cedric Vanluyten,Charlotte Schoenaers,René Novysedlák,Jan Van Slambrouck,Christelle Vandervelde,Hanne Beeckmans,Jan Havlin,Arne P Neyrinck,Piet Lormans,Karen Denaux,Dirk E Van Raemdonck,Robin Vos,Robert Lischke,Laurens J Ceulemans
The maximal donor age for lung transplantation (LTx) remains controversial, despite favorable outcomes with donors ≥70 years. We report our experience with LTx from donors ≥80 years. Donor/recipient characteristics and short-term postoperative outcome were retrospectively analyzed across two centers between 2016 and 2023. Seventeen patients underwent single (n=2) or double (n=15) LTx from octo- or
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Developing Approaches to Incorporate Donor Lung CT Images into Machine Learning Models to Predict Severe Primary Graft Dysfunction after Lung Transplantation. Am. J. Transplant. (IF 8.9) Pub Date : 2025-02-07 Weiwei Ma,Inez Oh,Yixuan Luo,Sayantan Kumar,Aditi Gupta,Albert M Lai,Varun Puri,Daniel Kreisel,Andrew E Gelman,Ruben Nava,Chad A Witt,Derek E Byers,Laura Halverson,Rodrigo Vazquez-Guillamet,Philip Ro Payne,Aristeidis Sotiras,Hao Lu,Khalid Niazi,Metin N Gurcan,Ramsey R Hachem,Andrew P Michelson
Primary graft dysfunction (PGD) is a common complication after lung transplantation associated with poor outcomes. Although risk factors have been identified, the complex interactions between clinical variables affecting PGD risk are not well understood, which can complicate decisions about donor lung acceptance. Previously, we developed a machine learning (ML) model to predict grade 3 PGD using donor
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Oropouche virus disease-region of the Americas. Am. J. Transplant. (IF 8.9) Pub Date : 2025-02-07 Marcus R Pereira
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Implications of Neoadjuvant Therapy on Prognostic Factors in Pancreatic Ductal Adenocarcinoma: A Path Towards Personalized Prognostication. Ann. Surg. (IF 7.5) Pub Date : 2025-02-07 Ammar A Javed,Joseph R Habib,Paul C M Andel,Brady A Campbell,Ingmar F Rompen,Omar Mahmud,Asad Fatimi,Iris W J M van Goor,Thijs J Schouten,Thomas F Stoop,Camila Hidalgo Salinas,Hjalmar C van Santvoort,Bas Groot Koerkam,I Quintus Molenaar,Christopher L Wolfgang,Marc G Besselink,Jin He,Lois A Daamen,
OBJECTIVE The aim of the study was to investigate prognostic factors in context of neoadjuvant therapy (NAT) and develop tools that can allow for accurate and personalized patient prognostication. SUMMARY OF BACKGROUND DATA NAT might impact the prognostic ability of well-established clinicopathological factors in resected pancreatic ductal adenocarcinoma (PDAC). METHODS Patients after resection for
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ACS NSQIP Surgical Risk Calculator Accuracy When Operative Risk is Represented by the Principal CPT® code Versus Many Codes. Ann. Surg. (IF 7.5) Pub Date : 2025-02-07 Mark E Cohen,Yaoming Liu,Bruce L Hall,Clifford Y Ko
OBJECTIVE To determine whether ACS NSQIP risk calculator (RC) accuracy can be improved by incorporating CPT codes beyond the principal code. BACKGROUND Because of technical limitations, past and current RC algorithms have relied only on the principal CPT code, represented as a logit score, to adjust for procedure-related risk. RC performance was evaluated when using a new machine learning (ML) algorithm
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Opinions vs. Evidence: Data-Driven Insights into the Organ Yield and Cost of Normothermic Regional Perfusion in Donation After Circulatory Death. Am. J. Transplant. (IF 8.9) Pub Date : 2025-02-06 Syed Shahyan Bakhtiyar,Tiffany E Maksimuk,Michael T Cain,Jordan R H Hoffman
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Response to Daungsupawong and Wiwanitkit's Editorial Comment on "Using Machine Learning for Personalized Prediction of Longitudinal COVID-19 Vaccine Responses in Transplant Recipients". Am. J. Transplant. (IF 8.9) Pub Date : 2025-02-06 Victor H Ferreira,Mamatha Bhat
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Induction of Immune Tolerance in Living Related HLA-Matched Kidney Transplantation: A Phase 3 Randomized Clinical Trial. Am. J. Transplant. (IF 8.9) Pub Date : 2025-02-06 Dixon B Kaufman,Sanjeev K Akkina,Mark D Stegall,James B Piper,A Osama Gaber,William S Asch,Stephan Busque,Erik Stites,Michael De Vera,Titte R Srinivas,Diane Alonso,Ashesh Shah,Anup Patel,Martin L Mai,Kenneth D Chavin,Meelie DebRoy,Arksarapuk Jittirat,Nadiesda Costa,Matthew Cooper,Gayle Vranic,Mark R Laftavi,Reza F Saidi,Suzon Collette,Daniel C Brennan,
This Phase 3 multi-center, randomized, controlled clinical trial evaluated investigational cellular product (MDR-101) to produce immune tolerance vs standard of care, in kidney transplant recipients. Adult recipients of kidneys from 2-haplotype HLA-matched living siblings were randomized 2:1 to Treatment (n=20) or Control (n=10). The MDR-101 product was from the same kidney donor. Treatment recipients
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Precise Monitoring of Transpulmonic Resistance in Bridge to Transplant Patients Supported by The Aeson Total Artificial Heart. J. Heart Lung Transplant. (IF 6.4) Pub Date : 2025-02-06 Yuriy Pya,Makhabbat Bekbossynova,Assel Medressova,Christian Latremouille,Piet Jansen,Ainur Tauyekelova,Rymbay Kaliyev,Saltanat Jetybayeva,Luke A Ziegler,Indranee Rajapreyar,J Eduardo Rame
The Aeson Total Artificial Heart (TAH) features embedded pressure sensors for flow autoregulation, which can also be used to estimate pressure gradients. In this bridge-to-transplant study, right and left ventricular pressure data and pump output from the TAH were analyzed to estimate trans-pulmonic resistance (eTPR) every 30 days. Three patients (aged 60, 35, and 54) with pre-implant pulmonary vascular
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Tumor Deposits-A Blind Spot in Colon Cancer Staging. JAMA Surg. (IF 15.7) Pub Date : 2025-02-05 Alizeh Abbas,Daniel I Chu
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The Morbidity of a Perineal Wound. JAMA Surg. (IF 15.7) Pub Date : 2025-02-05 Traci L Hedrick,Christopher A Campbell
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Generative Artificial Intelligence in Surgical Publishing JAMA Surg. (IF 15.7) Pub Date : 2025-02-05 Ben Li, Ahmed Kayssi, Lianne J. McLean
This Viewpoint discusses the role of generative artificial intelligence in surgical publishing, including idea generation, study conduct, manuscript preparation, and manuscript review.
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Validated Integration of Tumor Deposits in N Staging for Prognostication in Colon Cancer JAMA Surg. (IF 15.7) Pub Date : 2025-02-05 Richard Sassun, Annaclara Sileo, Jyi Cheng Ng, Tommaso Violante, Ibrahim Gomaa, Jay Mandrekar, Kristen K. Rumer, Nicholas P. McKenna, David W. Larson
ImportanceTumor deposits have prognostic value in colon cancer, but the current American Joint Committee on Cancer (AJCC) staging only considers them if there are no concurrent positive lymph nodes.ObjectiveTo devise a staging system for colon cancer by integrating counts of tumor deposits with positive lymph nodes while retaining the current AJCC staging framework.Design, Setting, and ParticipantsThis
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Perineal Wound Closure Using Gluteal Turnover Flap After Abdominoperineal Resection for Rectal Cancer JAMA Surg. (IF 15.7) Pub Date : 2025-02-05 Saskia I. Kreisel, Sarah Sharabiany, Jurriaan Tuynman, Eric H. J. Belgers, Baljit Singh, Sanjay Chaudhri, Anna A. W. van Geloven, Ronald J. C. L. M. Vuylsteke, Johannes H. W. de Wilt, Jarno Melenhorst, Jeroen W. A. Leijtens, Maarten Vermaas, Joost Rothbarth, Cornelis Verhoef, Johannes W. A. Burger, Fatih Polat, Hans F. J. Fabry, Arend G. J. Aalbers, Jan H. Wijsman, Bas Lamme, Jarmila D. W. van der
ImportancePerineal wound complications are common following abdominoperineal resection for rectal cancer and might have substantial and long-lasting implications for patients’ recovery.ObjectiveTo evaluate the superiority of gluteal turnover flap closure compared to primary closure in patients with rectal cancer undergoing abdominoperineal resection.Design, Setting, and ParticipantsThe BIOPEX-2 study
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Impact of continuous distribution as the allocation strategy on lung transplantation. Am. J. Transplant. (IF 8.9) Pub Date : 2025-02-05 Amit Banga,Christine Hartley,Zeynep Tulu,J W MacArthur,Gundeep Dhillon
In March 2023, the allocation strategy for lung transplantation (LT) underwent significant changes with the introduction of the new system, referred to as the continuous distribution (CD). The current paper describes the early impact of CD implementation on the mechanics of LT at a large tertiary care medical center. This was a retrospective study conducted across nine months before (March 2022 to
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Effects of Peripheral Nerve Block on Perioperative Recovery Following Major Thoracic and Abdominal Surgery: A Retrospective Cohort Study With Propensity-score Matching. Ann. Surg. (IF 7.5) Pub Date : 2025-02-05 Zhen Zhang,Chen Li,Zhen-Zhen Xu,Jia-Hui Ma,Dong-Xin Wang
OBJECTIVE To test the hypothesis that peripheral nerve block (PNB) use might be associated with improved perioperative outcomes following major surgery. SUMMARY BACKGROUND DATA PNB has been used to improve postoperative analgesia. METHODS This was a retrospective cohort study with propensity score matching. We included patients aged ≥65 years who underwent major (≥2 h) non-cardiac thoracic and abdominal
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Reconsidering Abdominal Drainage After Left Pancreatectomy - The Randomized Controlled PANDRA II Trial. Ann. Surg. (IF 7.5) Pub Date : 2025-02-05 Joerg Kaiser,Willem Niesen,Ulf Hinz,Markus K Diener,Frank Pianka,Rosa Klotz,Oliver Strobel,Arianeb Mehrabi,Christoph Berchtold,Beat Müller,Martin Schneider,Martin Loos,Christoph Michalski,Markus W Büchler,Thilo Hackert,Pascal Probst
OBJECTIVE Intraabdominal drainage following left pancreatectomy (LP) has been a longstanding practice to mitigate postoperative complications, particularly postoperative pancreatic fistulas (POPF). SUMMARY BACKGROUND DATA Recent studies challenge the necessity of routine drainage, suggesting potential benefits in omitting drains. METHODS The PANDRA II trial was a randomized controlled non-inferiority
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Multimodality Therapy Including Pleurectomy/Decortication in Pleural Mesothelioma: Long-Term Outcomes in 152 Consecutive Patients A Retrospective Cohort Study. Ann. Surg. (IF 7.5) Pub Date : 2025-02-05 Loïc Lang-Lazdunski,Yu Zhi Zhang,Andrew G Nicholson
OBJECTIVE Evaluate the long-term outcomes of pleurectomy decortication, systemic chemotherapy and prophylactic radiotherapy in pleural mesothelioma (PM). SUMMARY BACKGROUND DATA There is no known cure for PM and cytoreductive surgery remains controversial. METHODS Retrospective analysis of a cohort of patients treated consecutively between October 2004 and October 2019. Patients with PM were referred
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Volume Matters: Examining The Management Of Necrotizing Pancreatitis In The United States. Ann. Surg. (IF 7.5) Pub Date : 2025-02-04 Ikemsinachi C Nzenwa,Vahe S Panossian,Michael P DeWane,Katherine H Albutt,Yasmin G Hernandez-Barco,Carlos F Fernandez-Del Castillo,Keith D Lillemoe,Andrew L Warshaw,Peter J Fagenholz,Casey M Luckhurst
OBJECTIVE To examine the impact of hospital volume on mortality and healthcare utilization in patients admitted with necrotizing pancreatitis (NP). BACKGROUND Over 20% of patients with acute pancreatitis develop NP, which has been associated with higher rates of procedural intervention, morbidity, and mortality. METHODS Adult patients admitted with NP were identified in the 2016-2019 Nationwide Readmissions
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KRAS Mutations in Duodenal Lavage Fluid after Secretin Stimulation for Detection of Pancreatic Cancer. Ann. Surg. (IF 7.5) Pub Date : 2025-02-04 Shinichi Yachida,Shigetaka Yoshinaga,Satoshi Shiba,Makiko Urabe,Hidenori Tanaka,Yohei Takeda,Akinori Shimizu,Yuri Sakamoto,Susumu Hijioka,Shin Haba,Reiko Ashida,Yoshinori Kushiyama,Kento Asano,Makiko Kobayashi,Yoshiyuki Murawaki,Kouji Onishi,Taro Yamashita,Hirokazu Kimura,Yasushi Totoki,Hideki Kamada,Hajime Isomoto,Satoshi Hattori,Chigusa Morizane,Kazuyoshi Ohkawa,Masayuki Kitano,Kazuo Hara,Kenji Ikezawa
OBJECTIVE Although pancreatic ductal adenocarcinoma (PDAC) is still a devastating disease, the survival rate for surgically removed PDACs has significantly improved in recent years. Early detection is essential in managing PDAC. SUMMARY BACKGROUND DATA The presence of KRAS mutations in PDAC leads to the initial genetic abnormality and offers a significant timeframe for identifying resectable PDACs
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The Diabetes Remission Index (DRI): A Novel Prognostic Calculator Model Predicting Diabetes Remission Before and After Metabolic Procedures. Ann. Surg. (IF 7.5) Pub Date : 2025-02-04 Wissam Ghusn,Pearl Ma,Robert A Vierkant,Manpreet Mundi,Matyas Fehervari,Kayla Ikemiya,Karl Hage,Andres Acosta,Michael Camilleri,Barham Abu Dayyeh,Kelvin Higa,Omar M Ghanem
OBJECTIVE To develop and validate two predictive models, the Diabetes Remission Index (DRI) and the Weight Loss-Adjusted Diabetes Remission Index (W-DRI), for assessing type 2 diabetes (T2D) remission following metabolic and bariatric surgery (MBS). SUMMARY BACKGROUND DATA Metabolic and bariatric surgery, including Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG), is highly effective in
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Surveillance donor-specific antibody and pathologic antibody-mediated rejection testing in heart transplant patients in the contemporary era. J. Heart Lung Transplant. (IF 6.4) Pub Date : 2025-02-04 Vincenzo Cusi,Ashley Cardenas,Yuko Tada,Florin Vaida,Nicholas Wettersten,Jennifer Chak,Victor Pretorius,Marcus Anthony Urey,Gerald P Morris,Grace Lin,Paul J Kim
BACKGROUND Surveillance donor-specific antibody (DSA) and pathologic antibody-mediated rejection (pAMR) testing is recommended in the first year after heart transplantation (HTx) in adult patients. Whether pAMR testing adds prognostic information to contemporary DSA testing has not been fully studied. METHODS This was a single-center study of consecutive endomyocardial biopsies (EMB) performed between
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Detecting residual disease after neoadjuvant chemoradiotherapy for oesophageal squamous cell carcinoma: The prospective multicentre preSINO trial. Br. J. Surg. (IF 8.6) Pub Date : 2025-02-01 Yang Yang,Zhichao Liu,Ian Wong,Xing Gao,Hong Zhang,Jun Liu,Ben M Eyck,Jinchen Shao,Yuchen Han,Berend J van der Wilk,Yinkai Chao,Simon Law,Bas P L Wijnhoven,J Jan B van Lanschot,Zhigang Li
BACKGROUND Neoadjuvant chemoradiotherapy (nCRT) in patients with oesophageal squamous cell carcinoma (OSCC) may lead to clinical complete response (cCR). It is important to know the accuracy of clinical response evaluations (CREs) before advocating active surveillance instead of oesophagectomy. METHODS This was a prospective, multicentre study of patients with locally advanced OSCC. They received the
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Endoscopic appendix opening sphincter incision to remove faecolith. Br. J. Surg. (IF 8.6) Pub Date : 2025-02-01 Lili Dong,Suli Jiang,Pengmeng Li,Lin Fan,Yang Han,Shanling Zhang,Gang Bian
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YAP/TAZ overexpression activates mTOR and Erk1/2 signalling and is associated with worse outcomes for patients with pancreatic neuroendocrine neoplasms. Br. J. Surg. (IF 8.6) Pub Date : 2025-02-01 Yuta Shiraishi,Hiromitsu Hayashi,Zhao Liu,Jörg Schrader,Daisuke Ogawa,Sun Yuxuan,Xiaohan Wu,Shigeki Nakagawa,Kosuke Mima,Masaaki Iwatsuki
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The changing landscape of multimodal treatment for locally advanced oesophageal and junctional adenocarcinoma. Br. J. Surg. (IF 8.6) Pub Date : 2025-02-01 Sander J M van Hootegem,Bas P L Wijnhoven,
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Laparoscopic left hemihepatectomy using the Arantius-first approach after 90Y transarterial radioembolization and immunotherapy in a cirrhotic patient. Br. J. Surg. (IF 8.6) Pub Date : 2025-02-01 William Kawahara,Belen Rivera,Jeffrey Roberts,Cathleen Huang,Aishatu Ladu,George P Sorescu,Dmitry J Rabkin,Olga Kozyreva,Fernando Rotellar,Eduardo A Vega
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Utility of New Injury Severity Score (NISS) in assessing bullfighting trauma: experience from a level I hospital. Br. J. Surg. (IF 8.6) Pub Date : 2025-02-01 Manuel José Torres-Jurado,Juan Ramón Gómez-López,Jeancarlos Jhosmer Trujillo-Díaz,Francesco Schenone,Ana Benítez-Riesco,María Pilar Concejo-Cutoli,Laura Vicente-González,Carlos Vaquero Puerta,Juan Carlos Martín-Del Olmo
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Care of neuroendocrine tumours: the Collaborative of sUrgical Teams for NeuroEndocrine Tumors (CUTNETs). Br. J. Surg. (IF 8.6) Pub Date : 2025-02-01 Julie Hallet,Joel Shapiro,Andreas Pascher,Sébastien Gaujoux,Alexandra Gangi,Ismael Dominguez-Rosado,Massimo Falconi,Stefano Partelli,
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Preoperative stereotactic radiotherapy to prevent pancreatic fistula in high-risk patients undergoing pancreatoduodenectomy (FIBROPANC): prospective multicentre phase II single-arm trial. Br. J. Surg. (IF 8.6) Pub Date : 2025-02-01 Leonoor V Wismans,Tessa E Hendriks,J Annelie Suurmeijer,Joost J Nuyttens,Anna M Bruynzeel,Martijn P Intven,Lydi M van Driel,Roel Haen,Roeland F de Wilde,Bas Groot Koerkamp,Olivier R Busch,Jaap Stoker,Joanne Verheij,Arantza Farina,Onno J de Boer,Michail Doukas,Ignace H de Hingh,Daan J Lips,Erwin van der Harst,Geertjan van Tienhoven,Casper H van Eijck,Marc G Besselink,
BACKGROUND Postoperative pancreatic fistula is the main driver of morbidity and mortality after pancreatoduodenectomy. In high-risk patients, the rate of postoperative pancreatic fistula approaches 50%, whereas it is below 5% in patients with pancreatic cancer who receive neoadjuvant chemoradiotherapy. The aim of this study was to evaluate the safety, feasibility, and efficacy of preoperative stereotactic
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The Dynamics of Deceased Donor Kidney Transplant Decision-Making: Insights from Studying Individual Clinicians' Offer Decisions. Am. J. Transplant. (IF 8.9) Pub Date : 2025-01-31 Ellen Green,E Glenn Dutcher,Jesse D Schold,Darren Stewart
Despite the high demand, over 7,500 recovered kidneys annually go unused, with transplant centers showing significant variation in their offer acceptance practices. However, it remains unclear how much of this variation occurs between individual clinicians within the same center and its impact on allocation efficiency and equity. This study quantified the variability in kidney offer acceptance decisions
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Response to "The under-reporting of liver machine perfusion in US national data". Am. J. Transplant. (IF 8.9) Pub Date : 2025-01-31 Stalin Canizares,David D Lee
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Clinical predictors for restrictive allograft syndrome: a nested case-control study Am. J. Transplant. (IF 8.9) Pub Date : 2025-01-31 Hanne Beeckmans, Pieterjan Kerckhof, Acet Öztürk Nilufer, Andrea Zajacova, Jan Van Slambrouck, Saskia Bos, Marie Vermant, Lyne O. Van Dieren, Tessa Goeminne, Christelle Vandevelde, Josephine Bardyn, Elisabeth Willems, Sam Lauriers, Marius Brusselmans, Leen Van Langenhoven, Marie Paule Emonds, Steffi De Pelsmaeker, Johan Kerkhofs, Laurens De Sadeleer, Laurent Godinas, Lieven J. Dupont, Dirk E.Van Raemdonck
Risk factors for restrictive allograft syndrome (RAS), a severe phenotype of chronic lung allograft dysfunction (CLAD) after lung transplantation, are currently not well known. In this retrospective nested case-control-study, we analyzed 69 patients with RAS and 69 matched non-CLAD controls to identify clinical risk factors for RAS. Patients with RAS demonstrated overall higher blood eosinophils (P
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Validation of the PANAMA-Score for Survival and Benefit of Adjuvant Therapy in Patients with Resected Pancreatic Cancer After Neoadjuvant FOLFIRINOX. Ann. Surg. (IF 7.5) Pub Date : 2025-01-31 Ingmar F Rompen,Thomas F Stoop,Stijn van Roessel,Eran van Veldhuisen,Quisette P Janssen,Adnan Alseidi,Alberto Balduzzi,Gianpaolo Balzano,Frederik Berrevoet,Morgan Bonds,Olivier R Busch,Giovanni Butturini,Ammar A Javed,Marco Del Chiaro,Kevin C Conlon,Massimo Falconi,Isabella Frigerio,Giuseppe K Fusai,Johan Gagnière,Oonagh Griffin,Thilo Hackert,Ernesto Sparrelid,Asif Halimi,Knut J Labori,Giuseppe Malleo
AIM To validate the prognostic value of the PAncreatic NeoAdjuvant MAssachusetts (PANAMA)-score and to determine its predictive ability for survival benefit derived from adjuvant treatment in patients after resection of pancreatic ductal adenocarcinoma (PDAC) following neoadjuvant FOLFIRINOX. BACKGROUND The PANAMA-score was developed to guide prognostication in patients after neoadjuvant therapy and
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International Medical Graduates in Academic Cardiothoracic Surgery. Ann. Surg. (IF 7.5) Pub Date : 2025-01-31 Simar S Bajaj,Hanjay Wang,Kiah M Williams,Jack H Boyd
OBJECTIVE To assess the research productivity, career advancement, grant funding, and scholarly impact of international medical graduates (IMGs) in academic cardiothoracic surgery. SUMMARY BACKGROUND DATA Physician shortages undermine patient care and risk exacerbating inequities, especially in cardiothoracic surgery, which may lose a quarter of its workforce by 2050-the most substantial reduction