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Robotic versus Laparoscopic Liver Resection in Various Settings: An International Multicenter Propensity Score Matched Study of 10.075 Patients. Ann. Surg. (IF 9.0) Pub Date : 2024-03-14 Jasper P Sijberden, Tijs J Hoogteijling, Davit Aghayan, Francesca Ratti, Ek-Khoon Tan, Victoria Morrison-Jones, Jacopo Lanari, Louis Haentjens, Kongyuan Wei, Stylianos Tzedakis, John Martinie, Daniel Osei Bordom, Giuseppe Zimmitti, Kaitlyn Crespo, Paolo Magistri, Nadia Russolillo, Simone Conci, Burak Görgec, Andrea Benedetti Cacciaguerra, Daniel D'Souza, Gabriel Zozaya, Cèlia Caula, David Geller, Ricardo
The aim of this study was to compare the perioperative outcomes of robotic liver surgery (RLS) and laparoscopic liver surgery (LLS) in various settings.
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Medicaid Insurance Predicts Increased Postoperative Care Encounters Among Patients on Long-Term Opioid Therapy. Ann. Surg. (IF 9.0) Pub Date : 2024-03-14 Limi Sharif, Caroline S Zubieta, Akul Arora, Vidhya Gunaseelan, Jennifer Waljee, Mark C Bicket, Michael Englesbe, Chad M Brummett
This study examined the association between insurance type and postoperative unplanned care encounters among patients on long-term opioid therapy prior to surgery.
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A Pilot Study Using Machine Learning Algorithms and Wearable Technology for the Early Detection of Postoperative Complications After Cardiothoracic Surgery. Ann. Surg. (IF 9.0) Pub Date : 2024-03-14 Jorind Beqari, Joseph Powell, Jacob Hurd, Alexandra L Potter, Meghan McCarthy, Deepti Srinivasan, Danny Wang, James Cranor, Lizi Zhang, Kyle Webster, Joshua Kim, Allison Rosenstein, Zeyuan Zheng, Tung Ho Lin, Jing Li, Zhengyu Fang, Yuhang Zhang, Alex Anderson, James Madsen, Jacob Anderson, Anne Clark, Margaret E Yang, Andrea Nurko, Areej R El-Jawahri, Thoralf M Sundt, Serguei Melnitchouk, Arminder
To evaluate whether a machine learning algorithm (i.e. the "NightSignal" algorithm) can be used for the detection of postoperative complications prior to symptom onset after cardiothoracic surgery.
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The Association of Preoperative Opioid Use with Post-Discharge Outcomes: A Cohort Study of the Michigan Surgical Quality Collaborative. Ann. Surg. (IF 9.0) Pub Date : 2024-03-14 Stephan G Frangakis, Bethany Kavalakatt, Vidhya Gunaseelan, Yenling Lai, Jennifer Waljee, Michael Englesbe, Chad M Brummett, Mark C Bicket
To examine the association of prescription opioid fills over the year prior to surgery with postoperative outcomes.
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Association Of Opioid Prescribing And Consumption With Patient-Reported Experiences And Satisfaction Following Emergency Surgery In Michigan. Ann. Surg. (IF 9.0) Pub Date : 2024-03-14 Lindsay Rosenthal, Vidhya Gunaseelan, Jennifer Waljee, Mark Bicket, Michael Englesbe, Ryan Howard
To investigate the relationships between opioid prescribing, consumption, and patient reported outcomes (PROs) in emergency surgery patients.
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Distinctive Pathology Associated With Focal Stenosis of the Main Pancreatic Duct Secondary to Remote Trauma: A Long-term Complication of Seat Belt Pancreatitis. Am. J. Surg. Pathol. (IF 5.6) Pub Date : 2024-03-14 Annie A Wu, Elizabeth D Thompson, John L Cameron, Jin He, Richard A Burkhart, William R Burns, Kelly J Lafaro, Christopher R Shubert, Marcia I Canto, Elliot K Fishman, Ralph H Hruban
The radiologic finding of focal stenosis of the main pancreatic duct is highly suggestive of pancreatic cancer. Even in the absence of a mass lesion, focal duct stenosis can lead to surgical resection of the affected portion of the pancreas. We present four patients with distinctive pathology associated with non-neoplastic focal stenosis of the main pancreatic duct. The pathology included stenosis
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Reappraisal of p16 for Determining HPV Status of Head and Neck Carcinomas Arising in HPV Hotspots. Am. J. Surg. Pathol. (IF 5.6) Pub Date : 2024-03-14 Swati Bhardwaj, Melissa Gitman, Juan D Ramirez, Alberto Paniz-Mondolfi, William H Westra
In an era of head and neck oncology where HPV status will soon dictate patient management, reliable HPV detection is critical. P16 immunohistochemistry (IHC) is currently recommended as the test of choice for oropharyngeal squamous cell carcinomas (OPSCCs). The purpose of this study was to determine the performance characteristics of p16 IHC based on a large clinical experience of squamous cell carcinomas
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Operative Volumes and Postoperative Outcomes After Elective Resection of Congenital Lung Malformations in Infants. Ann. Surg. (IF 9.0) Pub Date : 2024-03-13 Abigail J Engwall-Gill, Jennine H Weller, Pooja S Salvi, Anne M Sescleifer, Annalise B Penikis, Shelby R Sferra, Kyra M Halbert-Elliott, Daniel S Rhee, Daniel G Solomon, Shaun M Kunisaki
To determine whether hospital- and surgeon-level operative volumes are associated with differences in postoperative outcomes among infants undergoing elective lung surgery for a congenital lung malformation (CLM).
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Immunosuppression Withdrawal in Living-donor Renal Transplant Recipients Following Induction with Anti-thymocyte Globulin and Rituximab: Results of a Prospective Clinical Trial Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-11 James F. Markmann, Bryna E. Burrell, Jonathan S. Bromberg, Choli Hartono, Dixon B. Kaufman, Andrew M. Possselt, Ali Naji, Nancy D. Bridges, Cynthia Breeden, Sai Kanaparthi, Jorge Pardo, Heather Kopetskie, Kristen Mason, Noha Lim, Sindhu Chandran
Durable tolerance in kidney transplant recipients remains an important but elusive goal. We hypothesized that adding B cell depletion to T cell depletion would generate an immune milieu post-reconstitution dominated by immature transitional B cells, favoring tolerance. The Immune Tolerance Network ITN039ST RESTARRT was a prospective multicenter pilot study of live donor kidney transplant recipients
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Banff 2022 liver group meeting report: monitoring long term allograft health Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-09 Christopher O.C. Bellamy, Jacqueline G. O'Leary, Oyedele Adeyi, Nahed Baddour, Ibrahim Batal, John Bucuvalas, Arnaud Del Bello, Mohamed El Hag, Magda El-Monayeri, Alton B. Farris III, Sandy Feng, Maria Isabel Fiel, Sandra E. Fischer, John Fung, Krzysztof Grzyb, Maha Guimei, Hironori Haga, John Hart, Annette M. Jackson, Elmar Jaeckel, Nigar A. Khurram, Stuart J. Knechtle, Drew Lesniak, Josh Levitsky
The Banff Working Group on Liver Allograft Pathology met in September 2022. Participants included hepatologists, surgeons, pathologists, immunologists and histocompatibility specialists. Presentations and discussions focused on the evaluation of long-term allograft health, including non-invasive and tissue monitoring, immunosuppression optimisation and long-term structural changes. Potential revision
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Letter to the Editor Living organ donation in polarized societies Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-08 Eytan Mor M.D.
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Morning Administration Enhances Humoral Response to SARS-CoV-2 Vaccination in Kidney Transplant Recipients Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-08 Ivan Zahradka, Filip Tichanek, Maria Magicova, Istvan Modos, Ondrej Viklicky, Vojtech Petr
Although SARS-CoV-2 mRNA vaccines are effective in kidney transplant recipients (KTRs), their immune response to vaccination is blunted by immunosuppression. Other tools enhancing vaccination response are therefore needed. Interestingly, aligning vaccine administration with circadian rhythms (chronovaccination) was shown to boost immune response. However, its applicability in KTRs, whose circadian
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Successful lung transplantation in genetic MARS-related alveolar proteinosis/lung fibrosis without recurrence under methionine supplementation:medium-term outcome in 4 cases. Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-08 Charlotte Roy, Nathalie Allou, Aurore Coulomb, Dominique Grenet, Raphaël Borie, Benjamin Zuber, Abdulmonem Hamid, Matthieu Glorion, Anne-Laure Brun, Elizabeth Longchamps, Alice Hadchouel, Olivier Brugiere
Pulmonary alveolar proteinosis (PAP) results from the accumulation of lipoproteinaceous material in the alveoli and alveolar macrophages, and can be associated with pulmonary fibrosis (PAP-PF), with a need for lung transplantation (LTx). Causes of PAP are autoimmune (90-95%), secondary (5%), or hereditary (<1%). Patients with hereditary PAP are generally not considered for isolated LTx, due to the
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Racism and tolerance in live kidney donation in Israel – response to Nesher et al Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-08 Ayelet Shai MD PhD
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Significance of Spread Through Air Spaces and Vascular Invasion in Early-stage Adenocarcinoma Survival: A Comprehensive Clinicopathologic Study of 427 Patients for Precision Management. Am. J. Surg. Pathol. (IF 5.6) Pub Date : 2024-03-05 Samuele Nicotra, Luca Melan, Federica Pezzuto, Alessandro Bonis, Stefano Silvestrin, Vincenzo Verzeletti, Giorgio Cannone, Alessandro Rebusso, Giovanni Maria Comacchio, Marco Schiavon, Andrea Dell'Amore, Fiorella Calabrese, Federico Rea
Spread through air spaces (STAS) is a novel invasive pattern of lung cancer associated with poor prognosis in non-small cell cancer (NSCLC). We aimed to investigate the incidence of STAS in a surgical series of adenocarcinomas (ADCs) resected in our thoracic surgery unit and to identify the association of STAS with other clinicopathological characteristics. We retrospectively enrolled patients with
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Functional maturation and longitudinal imaging of intraportal neonatal porcine islet grafts in genetically diabetic pigs Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-01 Johanna Pilz, Nicol Gloddek, Felix Lindheimer, Magdalena J. Lindner, Daniel Puhr-Westerheide, Muzzafer Ümütlü, Clemens Cyran, Max Seidensticker, Richard Lindner, Martin Kraetzl, Simone Renner, Daphne Merkus, Daniel Teupser, Peter Bartenstein, Sibylle I. Ziegler, Eckhard Wolf, Elisabeth Kemter
Allogeneic intraportal islet transplantation (ITx) has become an established treatment for patients with poorly controlled type 1 diabetes. However, the loss of viable beta-cell mass after transplantation remains a major challenge. Therefore, noninvasive imaging methods for long-term monitoring of the transplant fate are required. In this study, [Ga]Ga-DOTA-exendin-4 positron emission tomography/computed
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Factors Impacting Academic Productivity and Satisfaction of Surgeon-scientists: A Nationwide Survey. Ann. Surg. (IF 9.0) Pub Date : 2024-02-29 Paula Marincola Smith, Amy Martinez, Rebecca Irlmeier, Carmen C Solórzano, Deepa Magge, Fei Ye, James R Goldenring
To identify factors related to research success for academic surgeons.
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Survival and Quality of Life after Isolated Hepatic Perfusion with Melphalan as a Treatment for Uveal Melanoma Liver Metastases - Final Results from the Phase III Randomized Controlled Trial SCANDIUM. Ann. Surg. (IF 9.0) Pub Date : 2024-02-29 Roger Olofsson Bagge, Axel Nelson, Amir Shafazand, Charlotta All-Eriksson, Christian Cahlin, Nils Elander, Anders Gustavsson, Hildur Helgadottir, Jens Folke Kiilgaard, Sara Kinhult, Ingrid Ljuslinder, Jan Mattsson, Magnus Rizell, Malin Sternby Eilard, Gustav J Ullenhag, Jonas A Nilsson, Lars Ny, Per Lindnér
To investigate overall survival (OS) and health-related quality of life (HRQOL) of first-line isolated hepatic perfusion (IHP) compared to best alternative care (BAC) for patients with uveal melanoma liver metastases.
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Subsequent kidney transplant after pediatric heart transplant: Prevalence and risk factors Am. J. Transplant. (IF 8.8) Pub Date : 2024-02-29 Lucas D.G. Barrett, Kelli K. Ryckman, Amber M. Goedken, Emily Jane S. Steinbach, Ellen van der Plas, Gary Beasley, Rabia S. Khan, Vernat Exil, David A. Axelrod, Lyndsay A. Harshman
Pediatric heart failure and transplantation carry associated risks for kidney failure and potential need for kidney transplant following pediatric heart transplantation (KT/pHT). This retrospective, United Network of Organ Sharing study of 10 030 pediatric heart transplants (pHTs) from 1987 to 2020 aimed to determine the incidence of waitlisting for and completion of KT/pHT, risk factors for KT/pHT
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Challenging boundaries: Organ transplants from donors with listeria central nervous system infections Am. J. Transplant. (IF 8.8) Pub Date : 2024-02-29 Richard Lueking, Monica Fung, Elizabeth Ramos-Salazar, Sreelatha Katari, Geoffrey A. Funk, Cameron R. Wolfe, Ricardo M. La Hoz
Pretransplant mortality rates in the US remain high and are connected to effective organ donation and utilization. Thus, there is a need to maximize the utilization of available donors. In some cases, this has been safely achieved using organs from donors with infectious complications. For example, several studies describe the use of organs from donors with bacterial meningitis due to pathogens such
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Vasoplegic Syndrome during Heart Transplantation: A Systematic Review and Meta-analysis J. Heart Lung Transplant. (IF 8.9) Pub Date : 2024-02-28 Nicolas Kumar, Michael G. Fitzsimons, Manoj H. Iyer, Michael Essandoh, Julia E. Kumar, Adam A. Dalia, Asishana Osho, Tamara R. Sawyer, Amit Bardia
Vasoplegic syndrome (VS) is a common occurrence during heart transplantation (HT). It currently lacks a uniform definition between transplant centers, and its pathophysiology and treatment remain enigmatic. This systematic review summarizes the available published clinical data regarding VS during HT. We searched databases for all published reports on VS during HT. Data collected included the incidence
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Randomized Trial Of Routine Versus On-demand Intraoperative Extracorporeal Membrane Oxygenation In Lung Transplantation: A Feasibility Study J. Heart Lung Transplant. (IF 8.9) Pub Date : 2024-02-28 Basil Nasir, Jason Weatherald, Tim Ramsay, Marcelo Cypel, Laura Donahoe, Chris Durkin, Travis Schisler, Jayan Nagendran, Moishe Liberman, Caroline Landry, Charles Overbeek, Alex Moore, Pasquale Ferraro
In most centers, extracorporeal membrane oxygenation (ECMO) is the preferred means to provide cardiopulmonary support during lung transplantation. However, there is controversy about whether intraoperative venoarterial (VA) ECMO should be used routinely or selectively. A randomized controlled trial is the best way to address this controversy. In this publication, we describe a feasibility study to
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Biliary complications after adult-to-adult living-donor liver transplantation: An international multicenter study of 3633 cases Am. J. Transplant. (IF 8.8) Pub Date : 2024-02-28 Zhihao Li, Ashwin Rammohan, Vasanthakumar Gunasekaran, Suyoung Hong, Itsuko Chih-Yi Chen, Jongman Kim, Kris Ann Hervera Marquez, Shih Chao Hsu, Elvan Onur Kirimker, Nobuhisa Akamatsu, Oren Shaked, Michele Finotti, Marcus Yeow, Lara Genedy, Philipp Dutkowski, Silvio Nadalin, Markus U. Boehnert, Wojciech G. Polak, Glenn K. Bonney, Abhishek Mathur, Benjamin Samstein, Jean C. Emond, Giuliano Testa, Kim
In living-donor liver transplantation, biliary complications including bile leaks and biliary anastomotic strictures remain significant challenges, with incidences varying across different centers. This multicentric retrospective study (2016-2020) included 3633 adult patients from 18 centers and aimed to identify risk factors for these biliary complications and their impact on patient survival. Incidences
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Post-transplant Survival after Normothermic Regional Perfusion vs Direct Procurement and Perfusion in Donation after Circulatory Determination of Death Heart Transplantation J. Heart Lung Transplant. (IF 8.9) Pub Date : 2024-02-27 Gege Ran, Anji E. Wall, Nikhil Narang, Kiran K. Khush, Jordan R.H. Hoffman, Kevin C Zhang, William F. Parker
Since 2019, the annual transplantation rate of hearts donated following circulatory death (DCD) has increased significantly in the United States. The two major heart procurement techniques following circulatory death are direct procurement and perfusion (DPP) and normothermic regional perfusion (NRP). Post-transplant survival for heart recipients has not been compared between these two techniques.
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Impact of a Positive Crossmatch on Pediatric Heart Transplant Outcomes J. Heart Lung Transplant. (IF 8.9) Pub Date : 2024-02-27 Caitlin Milligan, Ryan J. Williams, Tajinder P. Singh, Heather J. Bastardi, Paul Esteso, Christopher S.D. Almond, Kimberlee Gauvreau, Kevin P. Daly
Pediatric heart transplant (HT) candidates experience high waitlist mortality due to a limited donor pool that is constrained in part by anti-HLA sensitization. We evaluated the impact of CDC and Flow donor-specific crossmatch (XM) results on pediatric HT outcomes. All pediatric HT between 1999 and 2019 in the OPTN database were included. Donor-specific XM results were sub-categorized based on CDC
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Reevaluating severe acute respiratory syndrome coronavirus-2 donor testing policies: Balancing safety and efficiency in organ transplantation Am. J. Transplant. (IF 8.8) Pub Date : 2024-02-27 Stephanie M. Pouch, Ricardo M. La Hoz
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REDISCOVER International Guidelines on the Perioperative Care of Surgical Patients With Borderline-resectable and Locally Advanced Pancreatic Cancer. Ann. Surg. (IF 9.0) Pub Date : 2024-02-26 Ugo Boggi, Emanuele Kauffmann, Niccolò Napoli, S George Barreto, Marc G Besselink, Giuseppe K Fusai, Thilo Hackert, Mohammad Abu Hilal, Giovanni Marchegiani, Roberto Salvia, Shailesh Shrikhande, Mark Truty, Jens Werner, Christopher Wolfgang, Elisa Bannone, Giovanni Capretti, Alice Cattelani, Alessandro Coppola, Alessandro Cucchetti, Davide De Sio, Armando Di Dato, Giovanna Di Meo, Claudio Fiorillo
The REDISCOVER consensus conference aimed at developing and validate guidelines on the perioperative care of patients with borderline resectable (BR-) and locally advanced (LA) pancreatic ductal adenocarcinoma (PDAC).
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Disparities in Access, Quality, and Clinical Outcome for Latino Californians with Colon Cancer. Ann. Surg. (IF 9.0) Pub Date : 2024-02-26 Aaron J Dawes, Ganesh Rajasekar, Katherine D Arnow, Amber W Trickey, Alex H S Harris, Arden M Morris, Todd H Wagner
To compare access, quality, and clinical outcomes between Latino and non-Latino White Californians with colon cancer.
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Trust-Building: Why Virtual Formats Threaten the Moral Ends of Surgical Informed Consent. Ann. Surg. (IF 9.0) Pub Date : 2024-02-26 John H Lee, Katherine E Neff, Christian J Vercler
The COVID-19 pandemic forced a wide range of medical practices to virtual formats, including the preoperative informed consent practice. However, virtual informed consent persists despite the pandemic largely considered resolved. The continued use of virtual formats relies on a problematic "information-transfer" model of informed consent. We suggest that a "trust-building" model of consent as a better
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Primary Pulmonary Myxoid Sarcoma and Thoracic Angiomatoid Fibrous Histiocytoma: Two Sides of the Same Coin? Am. J. Surg. Pathol. (IF 5.6) Pub Date : 2024-02-26 Allison L Kerper, Brandon T Larsen, Andrew L Folpe, Anja C Roden, Jorge Torres-Mora, Ying-Chun Lo, Marie-Christine Aubry, Jennifer M Boland
Primary pulmonary myxoid sarcoma (PPMS) and thoracic angiomatoid fibrous histiocytoma (AFH) are rare neoplasms with EWSR1 fusions and overlapping morphology. Both tumor types often show epithelial membrane antigen expression, but AFH characteristically co-expresses desmin. We encountered a case of PPMS with the unexpected finding of patchy, strong anaplastic lymphoma kinase (ALK) (previously reported
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COVID-19 infection is mild and has minimal impact on lung function in well vaccinated and widely treated lung transplant recipients J. Heart Lung Transplant. (IF 8.9) Pub Date : 2024-02-24 Samantha L. Ennis, Bronwyn J. Levvey, Helen V. Shingles, Sue J. Lee, Gregory I. Snell, Bradley J. Gardiner
COVID-19 has become a common infection affecting lung transplant recipients (LTR), who are at high risk for poor outcomes. Outcomes early in the pandemic were poor, but since the rollout of vaccination and novel COVID-19 treatments, outcomes of LTR have not been well described. Our aim was to evaluate the effect of COVID-19 on the clinical course and lung function trajectory in an Australian cohort
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Influence of socioeconomic status on rates of advanced heart failure therapies J. Heart Lung Transplant. (IF 8.9) Pub Date : 2024-02-24 Johan E. Larsson, Søren Lund Kristensen, Tania Deis, Peder E. Warming, Peter L. Graversen, Morten Schou, Lars Køber, Kasper Rossing, Finn Gustafsson
Socioeconomic deprivation is associated with a lower likelihood of referral for advanced heart failure (HF) evaluation, but it is not known whether it influences rates of advanced HF therapies independently of key hemodynamic measures and comorbidity following advanced HF evaluation in a universal healthcare system. We linked data from a single-center Danish clinical registry of consecutive patients
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Excess waitlist mortality among candidates for multivisceral liver-intestine transplant in acuity circle allocation Am. J. Transplant. (IF 8.8) Pub Date : 2024-02-24 Allison J. Kwong, Erin Schnellinger, Julia Foutz, Matt Cafarella, Shunji Nagai, Scott W. Biggins, James Pomposelli, James Trotter
Candidates for multivisceral transplant (MVT) have experienced decreased access to transplant in recent years. Using Organ Procurement and Transplantation Network data, transplant and waiting list outcomes for MVT (ie, liver-intestine, liver-intestine-pancreas, and liver-intestine-kidney-pancreas) candidates listed between February 4, 2018, and February 3, 2022, were analyzed, including model for end-stage
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Privacy-proof Live Surgery Streaming: Development and Validation of a low-cost, Real-time Robotic Surgery Anonymization Algorithm. Ann. Surg. (IF 9.0) Pub Date : 2024-02-23 Pieter De Backer, Jente Simoens, Kenzo Mestdagh, Jasper Hofman, Jennifer A Eckhoff, Mateusz Jobczyk, Ellen Van Eetvelde, Mathieu D'Hondt, Marcio Covas Moschovas, Vipul Patel, Charles Van Praet, Hans F Fuchs, Charlotte Debbaut, Karel Decaestecker, Alexandre Mottrie
Develop a pioneer surgical anonymization algorithm for reliable and accurate real-time removal of out-of-body images, validated across various robotic platforms.
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Impact of Change in Sizing Protocol on Outcome of Magnetic Sphincter Augmentation. Ann. Surg. (IF 9.0) Pub Date : 2024-02-23 Inanc S Sarici, Sven E Eriksson, Ping Zheng, Olivia Moore, Blair A Jobe, Shahin Ayazi
To evaluate and compare magnetic sphincter augmentation (MSA) device sizing protocols on postoperative outcomes and dysphagia.
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Distinguishing Clinical from Statistical Significances in Contemporary Comparative Effectiveness Research. Ann. Surg. (IF 9.0) Pub Date : 2024-02-23 Ajami Gikandi, Julie Hallet, Bas Groot Koerkamp, Clancy J Clark, Keith D Lillemoe, Raja R Narayan, Harvey J Mamon, Marco A Zenati, Nabil Wasif, Dana Gelb Safran, Marc G Besselink, David C Chang, Lara N Traeger, Joel S Weissman, Zhi Ven Fong
To determine the prevalence of clinical significance reporting in contemporary comparative effectiveness research (CER).
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Trends in End-of-Life Care and Satisfaction Among Veterans Undergoing Surgery. Ann. Surg. (IF 9.0) Pub Date : 2024-02-23 Shukri H A Dualeh, Maia S Anderson, Paul Abrahamse, Neil Kamdar, Emily Evans, Pasithorn A Suwanabol
To examine trends in end-of-life care services and satisfaction among Veterans undergoing any inpatient surgery.
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Impact of deceased organ donor marijuana use on donor culture positivity and solid organ transplant recipient outcomes Am. J. Transplant. (IF 8.8) Pub Date : 2024-02-23 Krista Moore, Ebbing Lautenbach, Emily A. Blumberg, Jennifer Han, Dong Heun Lee, Heather Clauss, Richard Hasz, Warren B. Bilker, Esther Molnar, Darcy Alimenti, Sharon West, Pam Tolomeo, Judith A. Anesi
With the increasing prevalence of marijuana use in the US, many deceased organ donors have a history of marijuana use, raising concerns about infectious risks to transplant recipients. We performed a multicenter retrospective cohort study in which exposed donors were those with recent marijuana use (in the prior 12 months) and unexposed donors were those with no recent marijuana use. Primary outcomes
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Fibrotic progression from acute cellular rejection is dependent on secondary lymphoid organs in a mouse model of chronic lung allograft dysfunction Am. J. Transplant. (IF 8.8) Pub Date : 2024-02-23 Katsutaka Mineura, Satona Tanaka, Yasufumi Goda, Yuriko Terada, Akihiko Yoshizawa, Keisuke Umemura, Atsuyasu Sato, Yoshito Yamada, Yojiro Yutaka, Akihiro Ohsumi, Daisuke Nakajima, Masatsugu Hamaji, Toshi Mennju, Daniel Kreisel, Hiroshi Date
Chronic lung allograft dysfunction (CLAD) remains one of the major limitations to long-term survival after lung transplantation. We modified a murine model of CLAD and transplanted left lungs from BALB/c donors into B6 recipients that were treated with intermittent cyclosporine and methylprednisolone postoperatively. In this model, the lung allograft developed acute cellular rejection on day 15 which
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Application of HLA molecular level mismatching in ethnically diverse kidney transplant recipients receiving a steroid-sparing immunosuppression protocol Am. J. Transplant. (IF 8.8) Pub Date : 2024-02-23 Eva Santos, Katrina Spensley, Nicola Gunby, Judith Worthington, Candice Roufosse, Arthi Anand, Michelle Willicombe
Defining HLA mismatch at the molecular compared with the antigen level has been shown to be superior in predicting alloimmune responses, although data from across different patient populations are lacking. Using HLA-Matchmaker, HLA-EMMA and PIRCHE-II, this study reports on the association between molecular mismatch (MolMM) and de novo donor-specific antibody (dnDSA) in an ethnically diverse kidney
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Utility of a Benchmarking Report for Balancing Infection Prevention and Antimicrobial Stewardship in Children with Complicated Appendicitis. Ann. Surg. (IF 9.0) Pub Date : 2024-02-22 Shannon L Cramm, Dionne A Graham, Martin L Blakely, Robert A Cowles, Shaun M Kunisaki, Aaron M Lipskar, Robert T Russell, Matthew T Santore, Jennifer R DeFazio, Cornelia L Griggs, Danielle I Aronowitz, Myron Allukian, Brendan T Campbell, Nicole M Chandler, Devon T Collins, Sarah J Commander, Katerina Dukleska, Justice C Echols, Joseph R Esparaz, Christina Feng, Claire Gerall, David N Hanna, Olivia
To develop a severity-adjusted, hospital-level benchmarking comparative performance report for postoperative organ space infection and antibiotic utilization in children with complicated appendicitis.
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The Effect of Perioperative Dexamethasone on Postoperative Complications after Pancreaticoduodenectomy: A Multicenter Randomized Controlled Trial. Ann. Surg. (IF 9.0) Pub Date : 2024-02-22 Haoda Chen, Ying Wang, Kuirong Jiang, Zhiwei Xu, Yu Jiang, Zhichong Wu, Xiaojian Lu, Chao Wang, Yuanchi Weng, Weishen Wang, Rui Ding, Shifan Zheng, Yilong Li, Xu Fu, Guodong Shi, Jiancheng Wang, Hao Chen, Chenghong Peng, Xiaxing Deng, Yudong Qiu, Yan Luo, Bei Sun, Baiyong Shen
This study aimed to evaluate the effect of perioperative dexamethasone on postoperative complications after pancreaticoduodenectomy.
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Anatomic Lung Resection Outcomes After Implementation of a Universal Thoracic ERAS Protocol Across a Diverse Healthcare System. Ann. Surg. (IF 9.0) Pub Date : 2024-02-22 Adam R Dyas, Christina M Stuart, Michael R Bronsert, Alyson D Kelleher, Kyle E Bata, Ethan U Cumbler, Crystal J Erickson, Matthew G Blum, Annette S Vizena, Alison R Barker, Lauren Funk, Karishma Sack, Benjamin A Abrams, Simran K Randhawa, Elizabeth A David, John D Mitchell, Michael J Weyant, Christopher D Scott, Robert A Meguid
We sought to evaluate how implementing a thoracic Enhanced Recovery After Surgery (ERAS) protocol impacted surgical outcomes after elective anatomic lung resection.
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Obesity is associated with a higher incidence of rejection in patients on belatacept: A pooled analysis from the BENEFIT/BENEFIT-EXT clinical trials Am. J. Transplant. (IF 8.8) Pub Date : 2024-02-21 Nicholas W. Lange, Kristen King, Syed Ali Husain, David M. Salerno, Demetra S. Tsapepas, Jessica Hedvat, Miko Yu, Sumit Mohan
Though belatacept is administered with a weight-based dosing schema, there has been higher clearance reported in obese patients. Therefore, we evaluated the association between body mass index (BMI) and transplant outcomes in kidney transplant recipients who were randomized to cyclosporine- or belatacept-based immunosuppression in the BENEFIT and BENEFIT-EXT randomized clinical trials. A total of 666
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Do children with Osteosarcoma benefit from Pulmonary Metastasectomy? - A Systematic Review Of Published Studies and 'Real world' Outcomes. Ann. Surg. (IF 9.0) Pub Date : 2024-02-20 Tristan Boam, Bethan G Rogoyski, Wajid Jawaid, Paul D Losty
To critically examine the evidence-base for survival benefit of Pulmonary metastasectomy (PM) for Osteosarcoma (OS) in the paediatric population.
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Looking Across the Drape: A Novel Quality Improvement Approach to Understanding Surgeon and Anesthesiologist Burnout. Ann. Surg. (IF 9.0) Pub Date : 2024-02-20 Jina L Sinskey, Rachel Schwartz, Christy K Boscardin, Joyce M Chang, Sandhya B Kumar, Carter C Lebares
To identify well-being threats for surgeons and anesthesiologists and develop interventions using the Quality of Life Improvement (QOLI) approach.
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Body Contouring Surgery after Bariatric Surgery Improves Long-term Health-related Quality of Life and Satisfaction with Appearance: An International Longitudinal Cohort Study Using the BODY-Q. Ann. Surg. (IF 9.0) Pub Date : 2024-02-20 Farima Dalaei, Claire E E de Vries, Lotte Poulsen, Sören Möller, Manraj N Kaur, Phillip J Dijkhorst, Jørn Bo Thomsen, Maarten Hoogbergen, Dennis J S Makarawung, Aebele B Mink van der Molen, Jussi P Repo, Marek Adam Paul, Kay-Hendrik Busch, Annalisa Cogliandro, Jakub Opyrchal, Michael Rose, Claus B Juhl, Alin M Andries, Andreas Printzlau, René K Støving, Anne F Klassen, Andrea L Pusic, Jens A Sørensen
To examine health-related quality of life (HRQL) and satisfaction with appearance in patients who have undergone bariatric surgery (BS) with or without subsequent body contouring surgery (BCS) in relation to the general population normative for the BODY-Q.
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Assessment of Laparoscopic Indocyanine Green Tracer-Guided Lymphadenectomy After Neoadjuvant Chemotherapy for Locally Advanced Gastric Cancer: A Randomized Controlled Trial. Ann. Surg. (IF 9.0) Pub Date : 2024-02-20 Ze-Ning Huang, Yi-Hui Tang, Qing Zhong, Ping Li, Jian-Wei Xie, Jia-Bin Wang, Jian-Xian Lin, Jun Lu, Long-Long Cao, Mi Lin, Ru-Hong Tu, Chao-Hui Zheng, Qi-Yue Chen, Chang-Ming Huang
To assess the effectiveness of indocyanine green (ICG)-guided lymph node (LN) dissection during laparoscopic radical gastrectomy after neoadjuvant chemotherapy (NAC) in patients with LAGC.
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IDEAL Phase 2a Results: Posterior Rectus Sheath Flap for Hiatal Augmentation in Complex Paraesophageal Hernias. Ann. Surg. (IF 9.0) Pub Date : 2024-02-20 Yalini Vigneswaran, Mustafa Hussain, M Alyssa Varsanik, Chase Corvin, Lawrence J Gottlieb, John C Alverdy
To report the developmental phase results of posterior rectus sheath hiatal flap augmentation (PoRSHA), a promising surgical innovation for large and recurrent paraesophageal hernias.
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Outcomes in solid organ transplant recipients with a pretransplant diagnosis of melanoma Am. J. Transplant. (IF 8.8) Pub Date : 2024-02-20 Fiona O. Zwald, Michael R. Sargen, April A. Austin, Mei-Chin Hsieh, Karen Pawlish, Jie Li, Charles F. Lynch, Kelly J. Yu, Eric A. Engels
Melanoma causes significant morbidity in solid organ transplant recipients (SOTRs). Melanomas diagnosed before transplantation can recur with intensive immunosuppression, but outcomes have not been well studied. We evaluated 901 non-Hispanic White SOTRs with a pretransplant melanoma identified using linked transplant and cancer registry data in the United States. Most pretransplant melanomas were invasive
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Private Equity Investment in Surgical Care. Ann. Surg. (IF 9.0) Pub Date : 2024-02-19 Maxwell T Sievers, Andrew Neevel, Adrian Diaz, Eva Rouanet, Kyle Sheetz, David Brophy, Justin B Dimick, Karan R Chhabra
To characterize the extent of private equity investment affecting surgical care.
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Compartment-specific remodeling patterns in end-stage chronic obstructive pulmonary disease with and without severe pulmonary hypertension J. Heart Lung Transplant. (IF 8.9) Pub Date : 2024-02-19 Katarina Zeder, Leigh Matthew Marsh, Alexander Avian, Luka Brcic, Anna Birnhuber, Philipp Douschan, Vasile Foris, Teresa Sassmann, Konrad Hoetzenecker, Panja Böhm, Grazyna Kwapiszewska, Andrea Olschewski, Horst Olschewski, Gabor Kovacs
In end-stage COPD patients, severe pulmonary hypertension (PH) is frequently associated with less severe airway obstruction as compared to mild or no PH. However, the histologic correlate of this finding is not clear. To quantify remodeling of pulmonary arteries, airways and parenchyma in random samples of explanted end-stage COPD lungs. We quantified thickening of small pulmonary arteries, remodeling
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Ki-67 Proliferation Index Is Associated With Tumor Grade and Survival in Pleural Epithelioid Mesotheliomas. Am. J. Surg. Pathol. (IF 5.6) Pub Date : 2024-02-19 Belinda Galeano, Caleb J Smith, Eunhee S Yi, Anja C Roden, Sarah Jenkins, Jenna Capelle, Mary Kittle-Francis, Aaron S Mansfield, Marie Christine Aubry
Pleural epithelioid mesothelioma (PEM) is divided into low and high grades based on nuclear atypia, mitoses, and necrosis in the tumor. Assessing mitoses and nuclear atypia tend to be labor-intensive with limited reproducibility. Ki-67 proliferation index was shown to be a prognostic factor in PEM, but its performance has not been directly correlated with tumor grade or mitotic score. This study evaluated
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Pan-cancer Genomic Analysis of AXL Mutations Reveals a Novel, Recurrent, Functionally Activating AXL W451C Alteration Specific to Myxofibrosarcoma. Am. J. Surg. Pathol. (IF 5.6) Pub Date : 2024-02-19 Erik A Williams, Isabella Vegas, Fardous F El-Senduny, Jessica Zhang, Douglas A Mata, Matthew C Hiemenz, Sarah R Hughes, Brianna C Sa, Garrett P Kraft, Nicole Gorbatov, Kathleen Foley-Peres, Edward Z Sanchez, Clara Milikowski, Kevin Jon Williams, Jeffrey S Ross, Razelle Kurzrock, Elizabeth A Montgomery, David B Lombard, Surinder Kumar
Myxofibrosarcoma (MFS) is a common soft tissue sarcoma of the elderly that typically shows low tumor mutational burden, with mutations in TP53 and in genes associated with cell cycle checkpoints (RB1, CDKN2A). Unfortunately, no alterations or markers specific to MFS have been identified and, as a consequence, there are no effective targeted therapies. The receptor tyrosine kinase AXL, which drives
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Donor heart preservation with controlled hypothermic technology: insights into the data J. Heart Lung Transplant. (IF 8.9) Pub Date : 2024-02-17 Michele Gallo, Mark S. Slaughter, Jaimin R. Trivedi
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Relationship Between Donor Derived Cell-Free DNA and Tissue-Based Rejection-Related Transcripts In Heart Transplantation J. Heart Lung Transplant. (IF 8.9) Pub Date : 2024-02-17 Dae Hyun Lee, Ahsan Usmani, Robby Wu, Tammi Wicks, Caroline Y Noh, Ryan Burke, Vani Ravichandran, Theresa Wolf-Doty, Ioana Dumitru, Guilherme H. Oliveira, Peter Berman, Benjamin Mackie
Endomyocardial biopsy (EMB)-based traditional microscopy remains the gold standard for the detection of cardiac allograft rejection, despite its limitation of inherent subjectivity leading to inter-reader variability. Alternative techniques now exist to surveil for allograft injury and classify rejection. Donor-derived cell-free DNA (dd-cfDNA) testing is now a validated blood-based assay used to surveil
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Liver stiffness is associated with right heart dysfunction, cardiohepatic syndrome, and prognosis in pulmonary hypertension J. Heart Lung Transplant. (IF 8.9) Pub Date : 2024-02-17 Zvonimir A. Rako, Athiththan Yogeswaran, Selin Yildiz, Peter Weidemann, Daniel Zedler, Bruno Brito da Rocha, Vitalii Kryvenko, Simon Schäfer, Hossein Ardeschir Ghofrani, Werner Seeger, Nils C. Kremer, Khodr Tello
Pulmonary hypertension (PH) can lead to congestive hepatopathy, known as cardiohepatic syndrome (CHS). Hepatic congestion is associated with increased liver stiffness, which can be quantified using shear wave elastography. We aimed to investigate whether hepatic shear wave elastography detects patients at risk in the early stages of PH. Sixty-three prospectively enrolled patients undergoing right heart