
样式: 排序: IF: - GO 导出 标记为已读
-
Ambient air pollution is associated with graft failure/death in pediatric liver transplant recipients. Am. J. Transplant. (IF 8.8) Pub Date : 2023-10-28 Jared E Yalung,Holly P Shifman,Erika Rasnick Manning,Andrew Beck,John Bucuvalas,Jennifer C Lai,Sharad I Wadhwani
Children exposed to disproportionately higher levels of air pollution experience worse health outcomes. In this population-based, observational registry study, we examine the association between air pollution and graft failure/death in children following liver transplantation (LT) in the US. We modeled the associations between air pollution (PM2.5) levels localized to the patient's ZIP code at the
-
Opening a Door: Organ Donation, Transplantation, and Pediatricians. Am. J. Transplant. (IF 8.8) Pub Date : 2023-10-25 By Lara C Pullen
-
Banff 2022 pancreas transplantation multidisciplinary report: Refinement of guidelines for T cell-mediated rejection, antibody-mediated rejection and islet pathology. Assessment of duodenal cuff biopsies and noninvasive diagnostic methods. Am. J. Transplant. (IF 8.8) Pub Date : 2023-10-21 Cinthia B Drachenberg,Maike Buettner-Herold,Pedro Ventura Aguiar,Catherine Horsfield,Alexei V Mikhailov,John C Papadimitriou,Surya V Seshan,Marcelo Perosa,Ugo Boggi,Pablo Uva,Michael Rickels,Krzyztof Grzyb,Lois Arend,Miriam Cuatrecasas,Maria Fernanda Toniolo,Alton B Farris,Karine Renaudin,Lizhi Zhang,Candice Roufousse,Angelika Gruessner,Rainer Gruessner,Raja Kandaswamy,Steven White,George Burke,Diego
The Banff pancreas working schema for diagnosis and grading of rejection is widely used for treatment guidance and risk stratification in centers that perform pancreas allograft biopsies. Since the last update, various studies have provided additional insight regarding the application of the schema and enhanced our understanding of additional clinicopathologic entities. This update aims to clarify
-
Outcomes of early vs late treatment initiation in solid organ transplantation from HCV NAT+ donors to HCV-uninfected recipients: Results from the HCV-TARGET study. Am. J. Transplant. (IF 8.8) Pub Date : 2023-10-21 Wesam Aleyadeh,Elizabeth C Verna,Hany Elbeshbeshy,Mark S Sulkowski,Coleman Smith,Jama Darling,Richard K Sterling,Andrew Muir,Lucy Akushevich,Danie La,Norah Terrault,Michael W Fried,Jordan J Feld
Curative hepatitis C (HCV) therapy has increased transplantation from HCV-infected (NAT+) donors to HCV-uninfected recipients (D+/R-). We evaluated outcomes of early and late HCV-treatment among D+/R- non-liver organ transplants. Patients received HCV regimens per local standard (n=10 sites). Outcomes were compared between early and late treatment. Early treatment regimens (ETR) (n=56) were initiated
-
Photobiomodulation promotes the functionality and viability of human pancreatic islets in basal conditions and under cytokine stress conditions. Am. J. Transplant. (IF 8.8) Pub Date : 2023-10-20 Quentin Perrier,Emily Tubbs,Pierre-Yves Benhamou,Cécile Moro,Sandrine Lablanche
-
Clinical characteristics and outcomes of liver transplant recipients infected by Omicron during the opening up of the dynamic zero-coronavirus disease policy in China: A prospective, observational study. Am. J. Transplant. (IF 8.8) Pub Date : 2023-10-18 Wei Zhang,Rongrong Wang,Pingbo Jin,Xinyu Yu,Weili Wang,Yuntao Zhang,Xueli Bai,Tingbo Liang
We analyzed the characteristics, risk factors, outcomes, and post-coronavirus disease 2019 (COVID-19) symptoms in liver transplant recipients in China's late 2022 COVID-19 wave. Recipients with COVID-19 were enrolled from December 1, 2022, to January 31, 2023, and followed up until May 31, 2023. Baseline and characteristic data were collected. A total of 930 recipients were included, with a vaccination
-
Pathologic-genomic correlation identified a novel variant in FN1 and established the diagnosis of recurrent fibronectin glomerulopathy in the kidney allograft. Am. J. Transplant. (IF 8.8) Pub Date : 2023-10-16 Ibrahim Batal,Samih H Nasr,Surendra Dasari,Astrid Weins,Natalie Vena,Michael B Stokes,Krzysztof Kiryluk,Gerald B Appel
Fibronectin glomerulopathy is a rare inherited kidney disease, characterized by abnormal accumulation of fibronectin in the glomeruli. We report an exceptional case of recurrent fibronectin glomerulopathy first diagnosed in the kidney allograft. The presence of IgA staining in the native kidney biopsy and the reported family history of IgA nephropathy had led to initial pretransplant diagnosis of IgA
-
COVID-19 Vaccine Mandates and the Owl of Minerva (editorial). Am. J. Transplant. (IF 8.8) Pub Date : 2023-10-13 Benjamin Hippen
-
Risk of cytomegalovirus infection and subsequent allograft failure after pancreas transplantation. Am. J. Transplant. (IF 8.8) Pub Date : 2023-10-13 Zachary A Yetmar,Yogish C Kudva,Maria Teresa Seville,Wendelyn Bosch,Janna L Huskey,Tambi Jarmi,Aleksandra Kukla,Patrick G Dean,Raymund R Razonable,Elena Beam
Cytomegalovirus (CMV) is a common cause of infection after transplantation, but few studies have evaluated its epidemiology, risk factors, and outcomes among pancreas transplant recipients. We performed a retrospective cohort study of adults who underwent pancreas transplantation from January 1, 2010, through December 31, 2020, at 3 sites in Arizona, Florida, and Minnesota. The primary outcome was
-
Combined Heart Liver Transplantation in the Patients with Advanced Liver Disease and/or Hepatocellular Carcinoma: Why Can't Liver Pull the Heart? Am. J. Transplant. (IF 8.8) Pub Date : 2023-10-13 Alexandra Shingina,Neha Bansal,Ari Cedars,Sharon Chen,Tami Daugherty,Juliet Emamaullee,Daniel Ganger,Jin Ge,Theo Heller,Dempsey Hughes,Joseph Kay,Juan Ortega Legaspi,Jonathan Menachem,Martin Montenovo,Jordan Sack,Leigh Reardon,Thomas Schiano,Kathleen Simpson,Jeffrey Teuteberg,Rose Tompkins,Irene Vodkin,Fred Wu,George Lui
-
Report of the 2022 Banff Heart Concurrent: Focus on non-human leukocyte antigen antibodies in rejection and the pathology of "mixed" rejection. Am. J. Transplant. (IF 8.8) Pub Date : 2023-10-12 Marny Fedrigo,Gerald J Berry,Guillaume Coutance,Elaine F Reed,Chieh-Yu Lin,Alessia Giarraputo,Evan Kransdorf,Olivier Thaunat,Martin Goddard,Annalisa Angelini,Desley A H Neil,Patrick Bruneval,Jean-Paul Duong Van Huyen,Alexandre Loupy,Dylan V Miller
The Banff Heart Concurrent Session, held as part of the 16th Banff Foundation for Allograft Pathology Conference at Banff, Alberta, Canada, on September 21, 2022, focused on 2 major topics: non-human leukocyte antigen (HLA) antibodies and mixed rejection. Each topic was addressed in a multidisciplinary fashion with clinical, immunological, and pathology perspectives and future developments and prospectives
-
Applying propensity methods to the United States transplant registry for external real-world evidence control arms for 5-year survival in the BENEFIT study. Am. J. Transplant. (IF 8.8) Pub Date : 2023-10-11 Amanda Klein,Alice Toll,Darren Stewart,William E Fitzsimmons
To address the challenges of assessing the impact of a reasonably likely surrogate endpoint on long-term graft survival in prospective kidney transplant clinical trials, the Transplant Therapeutics Consortium established a real-world evidence workgroup evaluating the scientific value of using transplant registry data as an external control to supplement the internal control group. The United Network
-
A scalable human islet 3D-culture platform maintains cell mass and function long-term for transplantation. Am. J. Transplant. (IF 8.8) Pub Date : 2023-10-07 Keiko Omori,Meirigeng Qi,Mayra Salgado,Nelson Gonzalez,Lauren T Hui,Kuan-Tsen Chen,Jeffrey Rawson,Lynn Miao,Hirotake Komatsu,Jeffrey S Isenberg,Ismail H Al-Abdullah,Yoko Mullen,Fouad Kandeel
Present-day islet culture methods provide short-term maintenance of cell viability and function, limiting access to islet transplantation. Attempts to lengthen culture intervals remain unsuccessful. A new method was developed to permit the long-term culture of islets. Human islets were embedded in polysaccharide 3D-hydrogel in cell culture inserts or gas-permeable chambers with serum-free CMRL 1066
-
Discretionary list diving optimizes kidney utilization. Am. J. Transplant. (IF 8.8) Pub Date : 2023-10-06 Robert J Stratta
-
Living donor liver transplantation for colorectal cancer liver metastases: Midterm outcomes at a single center in North America. Am. J. Transplant. (IF 8.8) Pub Date : 2023-10-06 Christof Kaltenmeier,David A Geller,Swaytha Ganesh,Samer Tohme,Michele Molinari,Amit Tevar,Christopher Hughes,Abhinav Humar
In recent years, liver transplantation has emerged as a treatment for patients with stage IV colorectal liver metastases (CRLM). Given the limited number of available deceased donor grafts, the use of living donor liver transplantation (LDLT) can be an important option. We performed a retrospective analysis of 10 patients that underwent LDLT for CRLM at our institution. A total of 90% of patients were
-
Need for Functional Validation of B Cell Trajectory in Transplant Tolerance. Am. J. Transplant. (IF 8.8) Pub Date : 2023-10-03 Hemant Sharma,Zaid Al-Almeidy,Sanjay Mehra
Guinn et al. reveal a shift from T cell to B cell dominance with regulatory B cell signatures in accepted allografts in mice. However, single-cell RNA sequencing has limitations in rare transcript detection that may introduce biases. Claims of a T to B cell transition require cautious interpretation. While early B cell infiltration was higher in accepted grafts, whether this is an outcome or driver
-
Kidney transplantation in a patient with anomalous iliofemoral vasculature. Am. J. Transplant. (IF 8.8) Pub Date : 2023-10-01 Wesley Dixon,Kyle Sheetz,Sandy Feng
-
Belatacept with Time-limited Tacrolimus Co-immunosuppression Modifies the 3-year Risk of Eplet Mismatch in Kidney Transplantation. Am. J. Transplant. (IF 8.8) Pub Date : 2023-09-29 Aileen C Johnson,Joan Zhang,Loren Gragert,Vicki Hertzberg,Christian P Larsen
Solid organ transplant donor-recipient eplet mismatch has been correlated with donor specific antibody (DSA) formation, antibody mediated rejection (AMR), and overall rejection rates. However, studies have been predominantly in patients on tacrolimus-based immunosuppression regimens and have not fully explored differences in ethnically and racially diverse populations. Evidence indicates patients on
-
Association of state Medicaid expansion policies with pediatric liver transplant outcomes. Am. J. Transplant. (IF 8.8) Pub Date : 2023-09-28 Holly Payton Shifman,Chiung-Yu Huang,Andrew F Beck,John Bucuvalas,Emily R Perito,Evelyn K Hsu,Noelle H Ebel,Jennifer C Lai,Sharad I Wadhwani
Children from minoritized/socioeconomically deprived backgrounds suffer disproportionately high rates of uninsurance and graft failure/death after liver transplant. Medicaid expansion was developed to expand access to public insurance. Our objective was to characterize the impact of Medicaid expansion policies on long-term graft/patient survival after pediatric liver transplantation. All pediatric
-
Recurrent atypical antiglomerular basement membrane nephritis in the kidney transplant. Am. J. Transplant. (IF 8.8) Pub Date : 2023-09-27 Salvatore E Mignano,Samih H Nasr,Mary E Fidler,Loren P Herrera Hernandez,Mariam P Alexander,Sanjeev Sethi,Nidia Messias,Tarek Alhamad,Louai Alrata,Sam T Albadri,Lynn D Cornell
Atypical antiglomerular basement membrane (anti-GBM) nephritis can be defined as linear GBM staining for monotypic or polytypic immunoglobulin (Ig) by immunofluorescence (IF) without a diffuse crescentic pattern. We describe the clinicopathologic features of 6 patients (18 biopsies) in this first series of recurrent atypical anti-GBM nephritis after kidney transplantation. Recurrent glomerulonephritis
-
Festina lente-to advance we need to make haste slowly. Living donor liver transplant for colorectal cancer liver metastases. Am. J. Transplant. (IF 8.8) Pub Date : 2023-09-26 Roberto Hernandez-Alejandro,Mariana Chávez-Villa,Pål-Dag Line,Gonzalo Sapisochin
-
First-in-human liver transplantation from a centenarian deceased donor after brain death. Am. J. Transplant. (IF 8.8) Pub Date : 2023-09-25 Paolo De Simone,Davide Ghinolfi,Simona Palladino,Gabriele Catalano,Caterina Martinelli,Juri Ducci,Jessica Bronzoni,Giovanni Tincani,Emanuele Balzano,Paola Carrai,Stefania Petruccelli,Daniela Campani,Laura Crocetti,Chiara Lazzeri,Giandomenico Biancofiore,Adriano Peris
Liver transplantation from elderly donors is expanding due to demand for liver grafts, aging of recipients and donors, and introduction of machine perfusion. We report on a liver transplant from a 100-year-old deceased donor after brain death. The liver was transplanted after the use of hypothermic machine perfusion to a 60-year-old recipient with advanced hepatocellular carcinoma undergoing neoadjuvant
-
Network Modernization Begins: The government's newly announced Organ Procurement and Transplantation Network Modernization Initiative heralds highly needed change. Am. J. Transplant. (IF 8.8) Pub Date : 2023-09-25 Lara C Pullen
-
Harnessing mixed chimerism and programmed cell death protein 1/programmed death ligand 1 signaling for transplant tolerance. Am. J. Transplant. (IF 8.8) Pub Date : 2023-09-25 Shuang Li,Dawei Zou
-
Pretransplantation coronavirus disease 2019 vaccination requirements: A matched case-control study of factors associated with waitlist inactivation. Am. J. Transplant. (IF 8.8) Pub Date : 2023-09-24 Anya L Edwards,Mehdi M Tavakol,Anna Mello,Jennifer Kerney,John P Roberts
Numerous United States transplant centers require solid organ transplantation candidates to be vaccinated against the coronavirus disease of 2019 to be active on the United Network for Organ Sharing waiting list. This study examined characteristics of adult patients on one center's kidney transplantation waiting list whose status was inactivated due to a lack of coronavirus disease 2019 vaccination
-
Model for End-Stage Liver Disease 3.0: One step forward to mitigate sex and gender disparities in liver transplant. Am. J. Transplant. (IF 8.8) Pub Date : 2023-09-24 Tzu-Hao Lee,Sonali Paul,Jeffrey Kahn
-
Characterizing the risk of human leukocyte antigen-incompatible living donor kidney transplantation in older recipients. Am. J. Transplant. (IF 8.8) Pub Date : 2023-09-23 Jane J Long,Jennifer D Motter,Kyle R Jackson,Jennifer Chen,Babak J Orandi,Robert A Montgomery,Mark D Stegall,Stanley C Jordan,Enrico Benedetti,Ty B Dunn,Lloyd E Ratner,Sandip Kapur,Ronald P Pelletier,John P Roberts,Marc L Melcher,Pooja Singh,Debra L Sudan,Marc P Posner,Jose M El-Amm,Ron Shapiro,Matthew Cooper,Jennifer E Verbesey,George S Lipkowitz,Michael A Rees,Christopher L Marsh,Bashir R Sankari
Older compatible living donor kidney transplant (CLDKT) recipients have higher mortality and death-censored graft failure (DCGF) compared to younger recipients. These risks may be amplified in older incompatible living donor kidney transplant (ILDKT) recipients who undergo desensitization and intense immunosuppression. In a 25-center cohort of ILDKT recipients transplanted between September 24, 1997
-
Temporal trends in kidney paired donation in the United States: 2006-2021 UNOS/OPTN database analysis. Am. J. Transplant. (IF 8.8) Pub Date : 2023-09-20 Neetika Garg,Carrie Thiessen,Peter P Reese,Matthew Cooper,Ruthanne Leishman,John Friedewald,Asif A Sharfuddin,Angie G Nishio Lucar,Darshana M Dadhania,Vineeta Kumar,Amy D Waterman,Didier A Mandelbrot
Kidney paired donation (KPD) is a major innovation that is changing the landscape of kidney transplantation in the United States. We used the 2006-2021 United Network for Organ Sharing data to examine trends over time. KPD is increasing, with 1 in 5 living donor kidney transplants (LDKTs) in 2021 facilitated by KPD. The proportion of LDKT performed via KPD was comparable for non-Whites and Whites.
-
Maintaining the permanence principle of death during normothermic regional perfusion in controlled donation after the circulatory determination of death: Results of a prospective clinical study. Am. J. Transplant. (IF 8.8) Pub Date : 2023-09-20 Mario Royo-Villanova,Eduardo Miñambres,José Moya Sánchez,Eduardo Torres,Clara Manso,María Ángeles Ballesteros,Guillermo Parrilla,Gonzalo de Paco Tudela,Elisabeth Coll,Alicia Pérez-Blanco,Beatriz Domínguez-Gil
One concern about the use of normothermic regional perfusion (NRP) in controlled donation after the circulatory determination of death (cDCD) is that the brain may be perfused. We aimed to demonstrate that certain technical maneuvers preclude such brain perfusion. A nonrandomized trial was performed on cDCD donors. In abdominal normothermic regional perfusion (A-NRP), the thoracic aorta was blocked
-
Aging exacerbates murine lung ischemia-reperfusion injury by excessive inflammation and impaired tissue repair response. Am. J. Transplant. (IF 8.8) Pub Date : 2023-09-19 Kazuki Hayasaka,Shinya Ohkouchi,Ryoko Saito-Koyama,Yamato Suzuki,Keito Okazaki,Hiroki Sekine,Tatsuaki Watanabe,Hozumi Motohashi,Yoshinori Okada
Donor shortage is a major problem in lung transplantation (LTx), and the use of lungs from elderly donors is one of the possible solutions in a rapidly aging population. However, the utilization of organs from donors aged >65 years has remained infrequent and may be related to a poor outcome. To investigate the molecular events in grafts from elderly donors early after LTx, the left lungs of young
-
Qualifying a novel clinical trial endpoint (iBOX) predictive of long-term kidney transplant outcomes. Am. J. Transplant. (IF 8.8) Pub Date : 2023-09-18 Amanda Klein,Alexandre Loupy,Mark Stegall,Ilkka Helanterä,Luke Kosinski,Eric Frey,Olivier Aubert,Gillian Divard,Kenneth Newell,Herwig-Ulf Meier-Kriesche,Roslyn B Mannon,Thomas Dumortier,Varun Aggarwal,Jagdeep T Podichetty,Inish O'Doherty,Ahmed Osama Gaber,William E Fitzsimmons,
New immunosuppressive therapies that improve long-term graft survival are needed in kidney transplant. Critical Path Institute's Transplant Therapeutics Consortium received a qualification opinion for the iBOX Scoring System as a novel secondary efficacy endpoint for kidney transplant clinical trials through European Medicines Agency's qualification of novel methodologies for drug development. This
-
Incomplete tissue product tracing during an investigation of a tissue-derived tuberculosis outbreak. Am. J. Transplant. (IF 8.8) Pub Date : 2023-09-15 Kristen E Marshall,Rebecca J Free,Thomas D Filardo,Noah G Schwartz,Alfonso C Hernandez-Romieu,Tyler C Thacker,Kimberly A Lehman,Pallavi Annambhotla,Peter B Dupree,Janet Burton Glowicz,Ann M Scarpita,Scott A Brubaker,Christopher A Czaja,Sridhar V Basavaraju
In the United States, there is currently no system to track donated human tissue products to individual recipients. This posed a challenge during an investigation of a nationwide tuberculosis outbreak that occurred when bone allograft contaminated with Mycobacterium tuberculosis (Lot A) was implanted into 113 patients in 18 US states, including 2 patients at 1 health care facility in Colorado. A third
-
Augmenting the Unites States transplant registry with external mortality data: A moving target ripe for further improvement. Am. J. Transplant. (IF 8.8) Pub Date : 2023-09-12 Samantha M Noreen,Rachel E Patzer,Sumit Mohan,Jesse D Schold,Grace R Lyden,Jonathan Miller,Scott Verbeke,Darren Stewart,Amber R Fritz,Maureen McBride,Jon J Snyder
The Organ Procurement and Transplantation Network conducts a robust death verification process when augmenting the United States transplant registry with external sources of data. Process enhancements added over 35,000 externally verified deaths across waitlist candidates and transplant recipients for all organs beginning in April 2022. Ninety-four percent of added posttransplant deaths occurred beyond
-
Impact of simultaneous heart procurement on outcomes of donation after circulatory death lung transplantation. Am. J. Transplant. (IF 8.8) Pub Date : 2023-09-04 Qimeng Gao,Arya Pontula,Isaac S Alderete,Isabel DeLaura,Riley Kahan,Kentaro Nakata,John C Haney,Jacob A Klapper,Matthew G Hartwig
Donation after circulatory death (DCD) heart procurement is done using either direct procurement (DP) or thoracoabdominal normothermic machine perfusion (TA-NRP). Both approaches could impact lung transplant outcomes with combined heart and lung procurements from the same donor. The impact of such practice on DCD lung transplant remains unstudied. We performed a retrospective analysis using the United
-
Personalizing kidney transplant donor-specific antibody surveillance: The devil is in the details. Am. J. Transplant. (IF 8.8) Pub Date : 2023-09-03 Nicole M Valenzuela,Roslyn B Mannon
-
International consensus recommendations on face transplantation: A 2-step Delphi study. Am. J. Transplant. (IF 8.8) Pub Date : 2023-09-02 Benedetto Longo,Fay Bound Alberti,Bohdan Pomahac,Julian Joseph Pribaz,Jean-Paul Meningaud,Benoît Lengelé,Ömer Özkan,Özlenen Özkan,Juan Pere Barret,Patrik Lassus,Phillip Blondeel,Nathalie Roche,Raffi Gurunian,Pedro Infante-Cossio,Andrew Lindford,Gerald Brandacher,Pietro Giovanoli,Jan Plock,Vijay S Gorantla,Emily Ruppel Herrington,Daniel Saleh,Ibrahim Natalwala,Massimo Cardillo,Sheila Jowsey-Gregoire
Face transplantation is a viable reconstructive approach for severe craniofacial defects. Despite the evolution witnessed in the field, ethical aspects, clinical and psychosocial implications, public perception, and economic sustainability remain the subject of debate and unanswered questions. Furthermore, poor data reporting and sharing, the absence of standardized metrics for outcome evaluation,
-
Supercooling Halts Biological Time: New technologies can multiply the number of hours that an organ remains viable for transplant. Am. J. Transplant. (IF 8.8) Pub Date : 2023-09-01 Lara C Pullen
-
Chronic gastrointestinal bleeding and anemia in a pancreas transplant recipient: A creative solution to a previously uncharacterized complication. Am. J. Transplant. (IF 8.8) Pub Date : 2023-09-01 Mario M Matabele,Laura Wolf,Juan S Danobeitia,Jon S Odorico
-
Sexual and gender minority relevant policies in Canadian and United States organ and tissue donation and transplantation systems: An opportunity to improve equity and safety. Am. J. Transplant. (IF 8.8) Pub Date : 2023-09-01 Murdoch Leeies,David Collister,Emily Christie,Karen Doucette,Carmen Hrymak,Tzu-Hao Lee,Ken Sutha,Julie Ho
Current policies in organ and tissue donation and transplantation (OTDT) systems in Canada and the United States unnecessarily restrict access to donation for sexual and gender minorities (SGMs) and pose safety risks to transplant recipients. We compare SGM-relevant policies between the Canadian and United States systems. Policy domains include the risk assessment of living and deceased organ and tissue
-
Neonatal islets from human PD-L1 transgenic pigs reduce immune cell activation and cellular rejection in humanized nonobese diabetic-scid IL2rγnull mice. Am. J. Transplant. (IF 8.8) Pub Date : 2023-08-31 Yutian Lei,Lelia Wolf-van Buerck,Mohsen Honarpisheh,Yichen Zhang,Reinhard Schwinzer,Bjoern Petersen,Jochen Seissler
Strong xenorejection limits the clinical application of porcine islet transplantation in type 1 diabetes. Targeting T cell-mediated rejection is one of the main approaches to improve long-term graft survival. Here we study engraftment and survival of porcine islet cells expressing human programmed cell death ligand-1 (hPD-L1) in a humanized mouse model. Neonatal islet-like clusters (NPICCs) from transgenic
-
What is visible is fixable: Visual dashboards for multi-domain assessment of organ procurement organization performance. Am. J. Transplant. (IF 8.8) Pub Date : 2023-08-30 Brianna L Doby,Kylie Casey,Katie Ross-Driscoll,Musaddiqur Rahman Ovi,Md Shabbir Hossain Bhuiyea,Istiak Ahmed Isty,Raymond J Lynch
With stakeholder focus on the United States organ procurement system, there is a need for tools that permit comparative assessment of organ procurement providers. We developed a public-facing dashboard for organ procurement organizations (OPOs), using data from multiple sources, to create an online, readily accessible visualization of OPO practice conditions and performance for the period 2010-2020
-
Risk factors, management, and clinical outcomes of invasive Mycoplasma and Ureaplasma infections after lung transplantation. Am. J. Transplant. (IF 8.8) Pub Date : 2023-08-30 Patrick C K Tam,Rochelle Hardie,Barbara D Alexander,Michael E Yarrington,Mark J Lee,Chris R Polage,Julia A Messina,Eileen K Maziarz,Jennifer L Saullo,Rachel Miller,Cameron R Wolfe,Sana Arif,John M Reynolds,John C Haney,John R Perfect,Arthur W Baker
Mollicute infections, caused by Mycoplasma and Ureaplasma species, are serious complications after lung transplantation; however, understanding of the epidemiology and outcomes of these infections remains limited. We conducted a single-center retrospective study of 1156 consecutive lung transplants performed from 2010-2019. We used log-binomial regression to identify risk factors for infection and
-
Predicting graft survival in pediatric kidney transplantation: Does the Box fit? Am. J. Transplant. (IF 8.8) Pub Date : 2023-08-29 Matthew Sypek,Anna Francis,Steve Chadban
-
Utilizing kidneys from a donor with bile-cast nephropathy. Am. J. Transplant. (IF 8.8) Pub Date : 2023-08-25 Hay Me Me,Pooja Budhiraja,Sumi Nair,Lavanya Kodali,Margaret Ryan,Hasan Khamash,Raymond Heilman,Josiah Wagler,Brianna Ruch,Caroline C Jadlowiec,Adyr Moss,Kunam S Reddy
Here we discuss the successful utilization of a pair of deceased donor kidneys with bile-cast nephropathy. The donor had a kidney donor profile index of 48% and an acute kidney injury requiring continuous renal replacement therapy. Peak donor bilirubin was 40.5 mg/dL, and renal wedge biopsies showed bile-cast nephropathy. Both recipients had delayed graft function lasting up to 4 weeks. The 4-month
-
De novo membranous nephropathy in a pig-to-baboon kidney xenograft: A new xenograft glomerulopathy. Am. J. Transplant. (IF 8.8) Pub Date : 2023-08-25 Ivy A Rosales,Kohei Kinoshita,Akihiro Maenaka,Ira Doressa Anne L How,Martin K Selig,Christina M Laguerre,A Bernard Collins,David Ayares,David K C Cooper,Robert B Colvin
De novo membranous nephropathy (dnMN) is an uncommon immune complex-mediated late complication of human kidney allografts that causes proteinuria. We report here the first case of dnMN in a pig-to-baboon kidney xenograft. The donor was a double knockout (GGTA1 and β4GalNT1) genetically engineered pig with a knockout of the growth hormone receptor and addition of 6 human transgenes (hCD46, hCD55, hTBM
-
Deacetylase sirtuin 2 negatively regulates myeloid-derived suppressor cell functions in allograft rejection. Am. J. Transplant. (IF 8.8) Pub Date : 2023-08-25 Yufei Wang,Yejin Cao,Linian Han,Likun Wang,Yijin Huang,Longhao Zhao,Yujing Bi,Guangwei Liu
Although myeloid-derived suppressor cells (MDSCs) are critical for allograft survival, their regulatory mechanism remains unclear. Herein, our results showed that metabolism sensor sirtuin 2 (SIRT2) negatively regulates the functions of MDSCs in inducing allogeneic skin graft rejection. Genetic deletion of SIRT2 in myeloid cells (Sirt2Δmye) increased the number of CD11b+Gr1+ MDSCs in bone marrow, spleens
-
Center variability in the prognostic value of a cumulative acute cellular rejection 'A-score' for long term lung transplant outcomes. Am. J. Transplant. (IF 8.8) Pub Date : 2023-08-23 N Belousova,E Huszti,Q Li,A Vasileva,R Ghany,R Gabarin,M El Sanharawi,C Picard,D Hwang,L Levy,S Keshavjee,C W Chow,A Roux,T Martinu
The Acute Rejection Score (A-score) in lung transplant recipients, calculated as the average of acute cellular rejection A-grades across transbronchial biopsies, summarises the cumulative burden of rejection over time. We assessed the association between A-score and transplant outcomes in two geographically distinct cohorts. The primary cohort included 772 double lung transplant recipients. The analysis
-
Smoking exposure-induced bronchus-associated lymphoid tissue in donor lungs does not prevent tolerance induction after transplantation. Am. J. Transplant. (IF 8.8) Pub Date : 2023-08-23 Yuriko Terada,Wenjun Li,Hailey M Shepherd,Tsuyoshi Takahashi,Yuhei Yokoyama,Amit I Bery,Katsutaka Mineura,Yun Zhu Bai,Jon H Ritter,Ramsey R Hachem,Ankit Bharat,Kory J Lavine,Ruben G Nava,Varun Puri,Alexander S Krupnick,Andrew E Gelman,Hasina Outtz Reed,Brian W Wong,Daniel Kreisel
The presence of bronchus-associated lymphoid tissue (BALT) in donor lungs has been suggested to accelerate graft rejection after lung transplantation. Although chronic smoke exposure can induce BALT formation, the impact of donor cigarette use on alloimmune responses after lung transplantation is not well understood. Here, we show that smoking-induced BALT in mouse donor lungs contains Foxp3+ T cells
-
Understanding the mechanisms and implications of the association between community distress and organ nonutilization. Am. J. Transplant. (IF 8.8) Pub Date : 2023-08-22 Kimberly Jacob Arriola
-
Pure laparoscopic donor hepatectomy: A nearly finished product. Am. J. Transplant. (IF 8.8) Pub Date : 2023-08-22 Benjamin Samstein,Daniel Cherqui
-
Clarification on the 6-month abdominal transplant recipient outcomes from donation after circulatory death heart donors: A retrospective analysis by procurement technique. Am. J. Transplant. (IF 8.8) Pub Date : 2023-08-19 Anji Elizabeth Wall,Matthew Rosenzweig,Gregory J McKenna,Tsung-Wei Ma,Sumeet K Asrani,Giuliano Testa
-
Risk for graft loss in pediatric and young adult kidney transplant recipients due to recurrent IgA nephropathy. Am. J. Transplant. (IF 8.8) Pub Date : 2023-08-16 Rachel M Engen,Sharon M Bartosh,Jodi M Smith,James D Perkins,Lyndsay A Harshman
IgA nephropathy (IgAN) is associated with a risk for posttransplant recurrence. Data are limited regarding graft loss attributable to recurrence of IgAN among pediatric and young adult kidney transplant (KT) recipients. This was a retrospective cohort study of patients aged 0 to 25 years from the Scientific Registry of Transplant Recipients who received a primary KT for IgAN. Patients with history
-
Novel 4-way simultaneous liver paired exchange: Is it generalizable? Am. J. Transplant. (IF 8.8) Pub Date : 2023-08-15 Dhiraj Agrawal,Kishore Kumar Ariga,Sanjiv Saigal
-
Impact of donor-specific anti-HLA antibody on cardiac hemodynamics and graft function 3 years after pediatric heart transplantation: First results from the CTOTC-09 multi-institutional study. Am. J. Transplant. (IF 8.8) Pub Date : 2023-08-12 Steven A Webber,Hyunsook Chin,James D Wilkinson,Brian D Armstrong,Charles E Canter,Anne I Dipchand,Debra A Dodd,Brian Feingold,Jacqueline M Lamour,William T Mahle,Tajinder P Singh,Warren A Zuckerman,Joseph W Rossano,Yvonne Morrison,Helena Diop,Anthony J Demetris,Carol Bentlejewski,Thalachallour Mohanakumar,Jonah Odim,Adriana Zeevi,
The aim of this study (CTOTC-09) was to assess the impact of "preformed" (at transplant) donor-specific anti-HLA antibody (DSA) and first year newly detected DSA (ndDSA) on allograft function at 3 years after pediatric heart transplantation (PHTx). We enrolled children listed at 9 North American centers. The primary end point was pulmonary capillary wedge pressure (PCWP) at 3 years posttransplant.
-
Response to: The expanded role of the transplant pharmacist: A 10-year follow-up by Lichvar et al. Am. J. Transplant. (IF 8.8) Pub Date : 2023-08-11 Angela Q Maldonado,Bharath Ravichandran,Timothy Horwedel,Kimi Ueda,Christin Rogers Marks,Matthew Everly,Erika Aldag,James Fleming
-
Disulfide-HMGB1 signals through TLR4 and TLR9 to induce inflammatory macrophages capable of innate-adaptive crosstalk in human liver transplantation. Am. J. Transplant. (IF 8.8) Pub Date : 2023-08-09 Allyson Q Terry,Hidenobu Kojima,Rebecca A Sosa,Fady M Kaldas,Jackson L Chin,Ying Zheng,Bita V Naini,Daisuke Noguchi,Jessica Nevarez-Mejia,Yi-Ping Jin,Ronald W Busuttil,Aaron S Meyer,David W Gjertson,Jerzy W Kupiec-Weglinski,Elaine F Reed
Ischemia-reperfusion injury (IRI) during orthotopic liver transplantation (OLT) contributes to graft rejection and poor clinical outcomes. The disulfide form of high mobility group box 1 (diS-HMGB1), an intracellular protein released during OLT-IRI, induces pro-inflammatory macrophages. How diS-HMGB1 differentiates human monocytes into macrophages capable of activating adaptive immunity remains unknown
-
T regulatory cell therapy: The price of specificity. Am. J. Transplant. (IF 8.8) Pub Date : 2023-08-09 Moritz Muckenhuber,Thomas Wekerle
-
Results of a multicenter cluster-randomized controlled clinical trial testing the effectiveness of a bioinformatics-enabled pharmacist intervention in transplant recipients. Am. J. Transplant. (IF 8.8) Pub Date : 2023-08-09 David J Taber,Ralph C Ward,Casey H Buchanan,Robert Neal Axon,Sherry Milfred-LaForest,Kelsey Rife,Rebecca Felkner,Danielle Cooney,Nicholas Super,Samantha McClelland,Domenica McKenna,Elizabeth Santa,Mulugeta Gebregziabher
An ambulatory medication safety dashboard was developed to identify missing labs, concerning labs, drug interactions, nonadherence, and transitions in care. This system was tested in a 2-year, prospective, cluster-randomized, controlled multicenter study. Pharmacists at 5 intervention sites used the dashboard to address medication safety issues, compared with usual care provided at 5 control sites
-
Theseus and the search for an antibody-mediated rejection molecular state in lung transplant biopsies. Am. J. Transplant. (IF 8.8) Pub Date : 2023-08-09 Daniel R Calabrese,John R Greenland
-
Sex as a biological variable: Mechanistic insights and clinical relevance in solid organ transplantation. Am. J. Transplant. (IF 8.8) Pub Date : 2023-08-04 Yao Xiao,Andreas Schroeter,Friederike Martin,Tomohisa Matsunaga,Keita Nakamori,Maximilian J Roesel,Marlena Habal,Anita S Chong,Hao Zhou,Stefan G Tullius
Biological sex affects immunity broadly, with recognized effects on the incidence and severity of autoimmune diseases, infections, and malignancies. Consequences of sex on alloimmunity and outcomes in solid organ transplantation are less well defined. Clinical studies have shown that donor and recipient sex independently impact transplant outcomes, which are further modified by aging. Potential mechanisms