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High-Intensity Interval Training vs Moderate-Intensity Continuous Training for Women Undergoing Cardiovascular Rehabilitation. JAMA Cardiol. (IF 30.154) Pub Date : 2022-06-15 Erik H Van Iterson,Luke J Laffin,Leslie Cho
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High-Intensity Interval Training vs Moderate-Intensity Continuous Training for Women Undergoing Cardiovascular Rehabilitation. JAMA Cardiol. (IF 30.154) Pub Date : 2022-06-15 Tasuku Terada,Sol Vidal-Almela,Jennifer L Reed
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Antithrombotic Therapy in Atrial Fibrillation and Coronary Artery Disease: Does Less Mean More? JAMA Cardiol. (IF 30.154) Pub Date : 2022-06-15 Ying X Gue,Diana A Gorog,Gregory Y H Lip
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Association of Sitting Time With Mortality and Cardiovascular Events in High-Income, Middle-Income, and Low-Income Countries. JAMA Cardiol. (IF 30.154) Pub Date : 2022-06-15 Sidong Li,Scott A Lear,Sumathy Rangarajan,Bo Hu,Lu Yin,Shrikant I Bangdiwala,Khalid F Alhabib,Annika Rosengren,Rajeev Gupta,Prem K Mony,Andreas Wielgosz,Omar Rahman,M Y Mazapuspavina,Alvaro Avezum,Aytekin Oguz,Karen Yeates,Fernando Lanas,Antonio Dans,Marc Evans M Abat,Afzalhussein Yusufali,Rafael Diaz,Patricio Lopez-Jaramillo,Lloyd Leach,P V M Lakshmi,Alicja Basiak-Rasala,Romaina Iqbal,Roya Kelishadi
Importance High amounts of sitting time are associated with increased risks of cardiovascular disease (CVD) and mortality in high-income countries, but it is unknown whether risks also increase in low- and middle-income countries. Objective To investigate the association of sitting time with mortality and major CVD in countries at different economic levels using data from the Prospective Urban Rural
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Rivaroxaban Monotherapy vs Combination Therapy With Antiplatelets on Total Thrombotic and Bleeding Events in Atrial Fibrillation With Stable Coronary Artery Disease: A Post Hoc Secondary Analysis of the AFIRE Trial. JAMA Cardiol. (IF 30.154) Pub Date : 2022-06-15 Ryo Naito,Katsumi Miyauchi,Satoshi Yasuda,Koichi Kaikita,Masaharu Akao,Junya Ako,Tetsuya Matoba,Masato Nakamura,Nobuhisa Hagiwara,Kazuo Kimura,Atsushi Hirayama,Kunihiko Matsui,Hisao Ogawa,
Importance Appropriate regimens of antithrombotic therapy for patients with atrial fibrillation (AF) and coronary artery disease (CAD) have not yet been established. Objective To compare the total number of thrombotic and/or bleeding events between rivaroxaban monotherapy and combined rivaroxaban and antiplatelet therapy in such patients. Design, Setting, and Participants This was a post hoc secondary
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High-Intensity Interval Training vs Moderate-Intensity Continuous Training for Women Receiving Cardiovascular Rehabilitation-Reply. JAMA Cardiol. (IF 30.154) Pub Date : 2022-06-15 Sherrie Khadanga,Patrick D Savage,Philip A Ades
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External Support for Saphenous Vein Grafts in Coronary Artery Bypass Surgery: A Randomized Clinical Trial. JAMA Cardiol. (IF 30.154) Pub Date : 2022-06-08 Daniel J Goldstein,John D Puskas,John H Alexander,Helena L Chang,James S Gammie,Mary E Marks,Alexander Iribarne,Yuliya Vengrenyuk,Samantha Raymond,Bradley S Taylor,Orit Yarden,Eyal Orion,François Dagenais,Gorav Ailawadi,Michael W A Chu,J Michael DiMaio,Jagat Narula,Ellen G Moquete,Karen O'Sullivan,Judson B Williams,Juan A Crestanello,Mariell Jessup,Eric A Rose,Vincent Scavo,Michael A Acker,Marc Gillinov
Importance Intimal hyperplasia and subsequent saphenous vein graft failure may have significant adverse clinical effects in patients undergoing coronary artery bypass surgery. External support of saphenous vein grafts has the potential to prevent vein graft dilation and hence slow the rate of intimal hyperplasia and increase long-term vein patency. Objective To determine efficacy, as measured by intimal
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Medicine, Writing, and the Limits of Language. JAMA Cardiol. (IF 30.154) Pub Date : 2022-05-25 Harold L Dauerman
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Antiabortion Laws and Implications for Patients With Cardiovascular Disease in Pregnancy. JAMA Cardiol. (IF 30.154) Pub Date : 2022-05-19 Verity N Ramirez,Melissa Ferraro-Borgida,Sarah Lindsay
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Hypertriglyceridemia in the MESA Study JAMA Cardiol. (IF 30.154) Pub Date : 2022-04-01 Boris Hansel,Ronan Roussel,Philippe Giral
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Hypertriglyceridemia in the MESA Study—Reply JAMA Cardiol. (IF 30.154) Pub Date : 2022-04-01 Jaideep Patel,Roger S. Blumenthal,Mahmoud Al Rifai
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High-Throughput Precision Phenotyping of Left Ventricular Hypertrophy With Cardiovascular Deep Learning JAMA Cardiol. (IF 30.154) Pub Date : 2022-04-01 Grant Duffy,Paul P. Cheng,Neal Yuan,Bryan He,Alan C. Kwan,Matthew J. Shun-Shin,Kevin M. Alexander,Joseph Ebinger,Matthew P. Lungren,Florian Rader,David H. Liang,Ingela Schnittger,Euan A. Ashley,James Y. Zou,Jignesh Patel,Ronald Witteles,Susan Cheng,David Ouyang
Importance Early detection and characterization of increased left ventricular (LV) wall thickness can markedly impact patient care but is limited by under-recognition of hypertrophy, measurement error and variability, and difficulty differentiating causes of increased wall thickness, such as hypertrophy, cardiomyopathy, and cardiac amyloidosis. Objective To assess the accuracy of a deep learning workflow
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A Man in His 60s With Pneumonia and Multiple Reintubation Attempts. JAMA Cardiol. (IF 30.154) Pub Date : 2022-03-09 Meng-Ko Tsai,Chao-Hung Lai,Li-Chien Chang
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Coronary Artery Calcium Testing in the Prevention of Atherosclerotic Cardiovascular Disease JAMA Cardiol. (IF 30.154) Pub Date : 2022-02-01 Philip Greenland, Donald M. Lloyd-Jones
This narrative review provides an overview of coronary artery calcium testing as a tool for risk assessment in the prevention of atherosclerotic cardiovascular disease.
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Addressing Imaging Pitfalls to Reduce Cardiovascular Disease Misdiagnosis in Patients With Breast Cancer Following Reconstruction JAMA Cardiol. (IF 30.154) Pub Date : 2022-02-01 Ohad Oren, Ron Blankstein, Deepak L. Bhatt
This Viewpoint discusses the challenges of cardiovascular imaging in patients with breast cancer after reconstruction.
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Evaluation of Quality of Care for Veterans With Recent-Onset HFrEF JAMA Cardiol. (IF 30.154) Pub Date : 2022-02-01 Alexander T. Sandhu, Shun Kohsaka, Mintu P. Turakhia, Eldrin F. Lewis, Paul A. Heidenreich
This cohort study evaluates the use of guideline-directed medical therapy and implantable cardioverter-defibrillator as well as mortality rates over a 6-year period among patients with heart failure with reduced ejection fraction in the US Department of Veterans Affairs health care system.
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Outcomes Associated With Catheter Ablation of VT in Patients With Cardiac Sarcoidosis JAMA Cardiol. (IF 30.154) Pub Date : 2022-02-01 Konstantinos C. Siontis, Pasquale Santangeli, Daniele Muser, Francis E. Marchlinski, Katja Zeppenfeld, Jarieke C. Hoogendoorn, Calambur Narasimhan, William H. Sauer, Matthew M. Zipse, Suraj Kapa, Vasanth Vedantham, David G. Rosenthal, Melissa R. Robinson, Kristen K. Patton, Francis Murgatroyd, Alexandru B. Chicos, Kyoko Soejima, Henri Roukoz, Frederic Sacher, Adarsh Bhan, Jason Appelbaum, Timm Dickfeld
This cohort study investigates outcomes associated with ventricular tachycardia ablation in patients with cardiac sarcoidosis.
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Racial, Ethnic, and Socioeconomic Disparities in Access to Transcatheter Aortic Valve Replacement in Metro Areas JAMA Cardiol. (IF 30.154) Pub Date : 2022-02-01 Ashwin S. Nathan, Lin Yang, Nancy Yang, Lauren A. Eberly, Sameed Ahmed M. Khatana, Elias J. Dayoub, Sreekanth Vemulapalli, Howard Julien, David J. Cohen, Brahmajee K. Nallamothu, Suzanne J. Baron, Nimesh D. Desai, Wilson Y. Szeto, Howard C. Herrmann, Peter W. Groeneveld, Jay Giri, Alexander C. Fanaroff
This national cross-sectional analysis examines the association between zip code–level racial, ethnic, and socioeconomic composition and rates of transcatheter aortic valve replacement among Medicare patients living within large metropolitan areas in the US.
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Race Bias in Transcatheter Aortic Valve Replacement Are We Sure? JAMA Cardiol. (IF 30.154) Pub Date : 2022-02-01 Clyde W. Yancy, Ajay Kirtane
Despite breakthrough science and innovative procedures, cardiovascular disease is rife with evidence-based racial disparities. Adopting quality initiatives, raising awareness, and inciting discussions about unconscious bias are recommended steps intended to narrow cardiovascular disease disparities. Progress is noted but a new challenge emerges. The implementation of transcatheter aortic valve replacement
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Individualized Studies of Triggers of Paroxysmal Atrial Fibrillation JAMA Cardiol. (IF 30.154) Pub Date : 2022-02-01 Gregory M. Marcus, Madelaine Faulkner Modrow, Christopher H. Schmid, Kathi Sigona, Gregory Nah, Jiabei Yang, Tzu-Chun Chu, Sean Joyce, Shiffen Gettabecha, Kelsey Ogomori, Vivian Yang, Xochitl Butcher, Mellanie True Hills, Debbe McCall, Kathleen Sciarappa, Ida Sim, Mark J. Pletcher, Jeffrey E. Olgin
This randomized clinical trial tests the hypothesis that n-of-1 trials of self-selected atrial fibrillation triggers would enhance atrial fibrillation–related quality of life.
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Metabolomic Analysis of Coronary Heart Disease in an African American Cohort JAMA Cardiol. (IF 30.154) Pub Date : 2022-02-01 Daniel E. Cruz, Usman A. Tahir, Jie Hu, Debby Ngo, Zsu-Zsu Chen, Jeremy M. Robbins, Daniel Katz, Raji Balasubramanian, Bennet Peterson, Shuliang Deng, Mark D. Benson, Xu Shi, Lucas Dailey, Yan Gao, Adolfo Correa, Thomas J. Wang, Clary B. Clish, Kathryn M. Rexrode, James G. Wilson, Robert E. Gerszten
This cohort study examines metabolites associated with incident coronary heart disease and coronary artery calcium among African American participants in the Jackson Heart Study and seeks to replicate coronary heart disease findings among multiethnic participants in the Women’s Health Initiative.
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Treating Severe Hypercholesterolemia—If Not Now, When? JAMA Cardiol. (IF 30.154) Pub Date : 2022-02-01 Neil J. Stone
Clinical guideline evidence matters. Recent 2018 American Heart Association/American College of Cardiology/Multisociety guidelines present strong evidence to support maximally tolerated statin therapy as a first step in patients aged 20 to 75 years with primary severe elevations of low-density lipoprotein cholesterol (LDL-C) of 190 mg/dL (to convert to millimoles per liter, multiply by 0.0259) or greater
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Economic Outcomes of Rehabilitation Therapy in Older Patients With Acute Heart Failure JAMA Cardiol. (IF 30.154) Pub Date : 2022-02-01 Derek S. Chew, Yanhong Li, Michel Zeitouni, David J. Whellan, Dalane Kitzman, Robert J. Mentz, Pamela Duncan, Amy M. Pastva, Gordon R. Reeves, M. Benjamin Nelson, Haiying Chen, Shelby D. Reed
This secondary analysis of a randomized clinical trial’s economic outcomes reports the cumulative medical resource use and costs during the 6-month follow-up period for patients randomized to an intervention or control condition for acute decompensated heart failure.
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Prevalence and Disease Spectrum of Extracoronary Arterial Abnormalities in Coronary Artery Dissection JAMA Cardiol. (IF 30.154) Pub Date : 2022-02-01 Alexandre Persu, Marilucy Lopez-Sublet, Abtehale Al-Hussaini, Marco Pappaccogli, Ibtissem Radhouani, Patricia Van der Niepen, William Adair, Christophe Beauloye, Pierre-Yves Brillet, Nathan Chan, Patrick Chenu, Hannes Devos, Javier Escaned, Marcos Garcia-Guimaraes, Frank Hammer, Robert Jackson, Salma Jebri, Deevia Kotecha, Fernando Macaya, Ciara Mahon, Nalin Natarajan, Kandiyil Neghal, Edward D. Nicol
This case series examines the prevalence of fibromuscular dysplasia and other extracoronary events in patients who develop spontaneous coronary artery dissection.
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Optimizing Training Response for Women in Cardiac Rehabilitation JAMA Cardiol. (IF 30.154) Pub Date : 2022-02-01 Sherrie Khadanga, Patrick D. Savage, Anton Pecha, Jason Rengo, Philip A. Ades
This randomized clinical trial evaluates the effect of high-intensity interval training and intensive lower extremity resistance training compared with standard moderate intensity continuous training on peak oxygen uptake among women in cardiac rehabilitation.
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Association of Health Care Processes With Racial or Ethnic Disparities in Blood Pressure Control JAMA Cardiol. (IF 30.154) Pub Date : 2022-02-01 Valy Fontil, Lucia Pacca, Brandon K. Bellows, Elaine Khoong, Charles E. McCulloch, Mark Pletcher, Kirsten Bibbins-Domingo
This cohort study assesses whether and to what extent differences in treatment intensification, scheduled follow-up interval, and missed visits are associated with racial and ethnic disparities in blood pressure control among adults with hypertension.
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Inclusion of Smoking Data in Cardiovascular Disease Risk Estimation JAMA Cardiol. (IF 30.154) Pub Date : 2022-02-01 Meredith S. Duncan, Robert A. Greevy, Hilary A. Tindle, Ramachandran S. Vasan, Loren Lipworth, Melinda C. Aldrich, Donald M. Lloyd-Jones, Matthew S. Freiberg
This cohort study evaluates the predictive utility of adding former smoking status, pack-years smoked, and years since quitting to the American College of Cardiology/American Heart Association 2013 pooled cohort equations for more accurate atherosclerotic cardiovascular disease risk prediction.
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Error in the First Paragraph JAMA Cardiol. (IF 30.154) Pub Date : 2022-02-01
In the Editorial titled, “The Potential and Pitfalls of Coronary Artery Calcium Scoring,” which published online October 27, 2021, the following sentence is incorrect: “Beyond this recommendation, however, some investigators have called for even more aggressive de-risking of patients with a CAC score of 0, suggesting that even those with familial hypercholesterolemia and a CAC score of 0 may not need
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Role of Income-Lifting Social Programs in Reducing Years of Life Lost to Myocardial Infarction and Sudden Death—Reply JAMA Cardiol. (IF 30.154) Pub Date : 2022-02-01 Adam N. Berman, Ersilia M. DeFilippis, Ron Blankstein
In Reply We appreciate the letter by Senter and colleagues highlighting the important implications of socioeconomic deprivation on clinical outcomes. As our research highlighted, neighborhood-level socioeconomic disadvantage is associated with increasing all-cause and cardiovascular mortality in individuals 50 years and younger who experienced a first myocardial infarction over an 11-year follow-up
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Role of Income-Lifting Social Programs in Reducing Years of Life Lost to Myocardial Infarction and Sudden Death JAMA Cardiol. (IF 30.154) Pub Date : 2022-02-01 Elizabeth Senter, Hannah Vrooman, Kaitlin Shartle
To the Editor We appreciate the work of Berman and colleagues, who investigated the association between socioeconomic disadvantage and mortality after a myocardial infarction (MI). The authors found that among people who had an MI before age 50 years, patients who lived in the most disadvantaged neighborhoods had a higher risk of all-cause and cardiovascular mortality. These findings suggest that addressing
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Hereditary Transthyretin Amyloid Cardiomyopathy JAMA Cardiol. (IF 30.154) Pub Date : 2022-02-01 Quentin R. Youmans, Sanjiv J. Shah, Sadiya S. Khan
This Patient Page describes the causes, symptoms, diagnosis, genetic testing, and treatment of amyloidogenic transthyretin.
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Lifestyle Modification Is Appropriate as Primary Prevention JAMA Cardiol. (IF 30.154) Pub Date : 2022-02-01 Harry A. Conte, Sok-Ja Janket, Eleftherios P. Diamandis
To do nothing is sometimes a good remedy.Hippocrates
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A Man With Left Ventricular Hypertrophy JAMA Cardiol. (IF 30.154) Pub Date : 2022-02-01 Nana Hiraki, Toshikazu D. Tanaka, Michihiro Yoshimura
A man in his 40s with a 20-year history of bilateral sensorineural hearing loss was referred for evaluation of left ventricular hypertrophy detected by echocardiography. On physical examination, he was 154 cm tall and weighed 38 kg and neurological examination showed mild cognitive impairment, poor coordination, and muscle weakness of the bilateral lower limbs. What would you do next?
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The Gig Economy Worker—A New Social Determinant of Health? JAMA Cardiol. (IF 30.154) Pub Date : 2022-02-01 Fatima Rodriguez, Ashish Sarraju, Mintu P. Turakhia
This Viewpoint discusses how the rapid rise of the gig economy has resulted in a fast-growing workforce segment with unique health vulnerabilities.
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A Combined Echocardiography Approach for the Diagnosis of Cancer Therapy-Related Cardiac Dysfunction in Women With Early-Stage Breast Cancer. JAMA Cardiol. (IF 30.154) Pub Date : 2022-03-01 Maryam Esmaeilzadeh,Camila M Urzua Fresno,Emily Somerset,Tamar Shalmon,Eitan Amir,Chun-Po Steve Fan,Christine Brezden-Masley,Babitha Thampinathan,Yobiga Thevakumaran,Kibar Yared,C Anne Koch,Husam Abdel-Qadir,Anna Woo,Paul Yip,Thomas H Marwick,Rosanna Chan,Bernd J Wintersperger,Paaladinesh Thavendiranathan
IMPORTANCE Diagnosis of cancer therapy-related cardiac dysfunction (CTRCD) remains a challenge. Cardiovascular magnetic resonance (CMR) provides accurate measurement of left ventricular ejection fraction (LVEF), but access to repeated scans is limited. OBJECTIVE To develop a diagnostic model for CTRCD using echocardiographic LVEF and strain and biomarkers, with CMR as the reference standard. DESIGN
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A 49-Year-Old Woman With Progressive Dyspnea. JAMA Cardiol. (IF 30.154) Pub Date : 2022-02-09 Hai-Long Dai,Wei-Hua Zhang,Xue-Feng Guang
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Consequences of Inaccurate Assumptions in Coronary Stent Noninferiority Trials: A Systematic Review and Meta-analysis. JAMA Cardiol. (IF 30.154) Pub Date : 2022-03-01 Matheus Simonato,Ori Ben-Yehuda,Flavien Vincent,Zixuan Zhang,Björn Redfors
IMPORTANCE The outcome and interpretation of noninferiority trials depend on the magnitude of the noninferiority margin and whether a relative or absolute noninferiority margin is used and may be affected by imprecision in event rate estimation. OBJECTIVE To assess the consequence of imprecise event rate estimations on interpretation of peer-reviewed randomized clinical trials. DATA SOURCES PubMed/MEDLINE
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Noninferiority Margins in Clinical Trials-A Moving Target? JAMA Cardiol. (IF 30.154) Pub Date : 2022-03-01 Li Wang,Rebecca Torguson,Andrew Farb
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Leadless Pacing-Uncertainties Remain About Safety and Efficacy. JAMA Cardiol. (IF 30.154) Pub Date : 2022-03-01 Linh Ngo,Russell Denman,Isuru Ranasinghe
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Association of Plaque Location and Vessel Geometry Determined by Coronary Computed Tomographic Angiography With Future Acute Coronary Syndrome-Causing Culprit Lesions. JAMA Cardiol. (IF 30.154) Pub Date : 2022-03-01 Donghee Han,Andrew Lin,Keiichiro Kuronuma,Evangelos Tzolos,Alan C Kwan,Eyal Klein,Daniele Andreini,Jeroen J Bax,Filippo Cademartiri,Kavitha Chinnaiyan,Benjamin J W Chow,Edoardo Conte,Ricardo C Cury,Gudrun Feuchtner,Martin Hadamitzky,Yong-Jin Kim,Jonathon A Leipsic,Erica Maffei,Hugo Marques,Fabian Plank,Gianluca Pontone,Todd C Villines,Mouaz H Al-Mallah,Pedro de Araújo Gonçalves,Ibrahim Danad,Heidi
IMPORTANCE Distinct plaque locations and vessel geometric features predispose to altered coronary flow hemodynamics. The association between these lesion-level characteristics assessed by coronary computed tomographic angiography (CCTA) and risk of future acute coronary syndrome (ACS) is unknown. OBJECTIVE To examine whether CCTA-derived adverse geometric characteristics (AGCs) of coronary lesions
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Leadless Pacing-Uncertainties Remain About Safety and Efficacy-Reply. JAMA Cardiol. (IF 30.154) Pub Date : 2022-03-01 Mikhael F El-Chami,Jonathan P Piccini,Lindsay Bockstedt
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Wide Complex QRS During Sotalol Administration. JAMA Cardiol. (IF 30.154) Pub Date : 2022-03-01 Albert J Rogers,Paul J Wang,Nitish Badhwar
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Updated USPSTF Guidelines for Screening for Atrial Fibrillation: Same as It Ever Was? JAMA Cardiol. (IF 30.154) Pub Date : 2022-03-01 Rod Passman,Ben Freedman
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Association of N-Terminal Pro-Brain Natriuretic Peptide Concentration in Early Pregnancy With Development of Hypertensive Disorders of Pregnancy and Future Hypertension. JAMA Cardiol. (IF 30.154) Pub Date : 2022-03-01 Alisse Hauspurg,Derek J Marsh,Rebecca B McNeil,C Noel Bairey Merz,Philip Greenland,Adam C Straub,Caroline E Rouse,William A Grobman,Victoria L Pemberton,Robert M Silver,Yii-Der Ida Chen,Brian M Mercer,Lisa D Levine,Afshan Hameed,Matthew K Hoffman,Hyagriv N Simhan,Janet M Catov,
IMPORTANCE Hypertensive disorders of pregnancy are associated with future cardiovascular disease, perhaps because of subclinical cardiac dysfunction before pregnancy leading to impaired adaptation to pregnancy. Natriuretic peptides are promising biomarkers for detecting subclinical cardiac dysfunction outside of pregnancy. OBJECTIVE To investigate whether higher concentrations of N-terminal pro-brain
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Center-Level Variation in Transplant Rates Following the Heart Allocation Policy Change. JAMA Cardiol. (IF 30.154) Pub Date : 2022-03-01 Zachary Tran,Roland Hernandez,Josef Madrigal,Samuel T Kim,Arjun Verma,David G Rabkin,Peyman Benharash
IMPORTANCE Wide state-level variability in waiting list outcomes have been noted for patients listed for heart transplant in the US, but little is known regarding center-level transplant rates since the heart allocation policy change. OBJECTIVE To evaluate center-level transplant rates following the recent allocation policy change for heart transplant. DESIGN, SETTING, AND PARTICIPANTS This cohort
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Combined Cardiac Fluorodeoxyglucose–Positron Emission Tomography/Magnetic Resonance Imaging Assessment of Myocardial Injury in Patients Who Recently Recovered From COVID-19 JAMA Cardiol. (IF 30.154) Pub Date : 2022-01-12 Kate Hanneman, Christian Houbois, Alice Schoffel, Dakota Gustafson, Robert M. Iwanochko, Bernd J. Wintersperger, Rosanna Chan, Jason E. Fish, Kathryn L. Howe, Paaladinesh Thavendiranathan
Importance Although myocardial injury can occur with acute COVID-19, there is limited understanding of changes with myocardial metabolism in recovered patients. Objective To examine myocardial metabolic changes early after recovery from COVID-19 using fluorodeoxyglucose–positron emission tomography (PET) and associate these changes to abnormalities in cardiac magnetic resonance imaging (MRI)–based
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Effect of Treatment With Sacubitril/Valsartan in Patients With Advanced Heart Failure and Reduced Ejection Fraction: A Randomized Clinical Trial JAMA Cardiol. (IF 30.154) Pub Date : 2022-01-01 Douglas L. Mann, Michael M. Givertz, Justin M. Vader, Randall C. Starling, Palak Shah, Steven E. McNulty, Kevin J. Anstrom, Kenneth B. Margulies, Michael S. Kiernan, Claudius Mahr, Divya Gupta, Margaret M. Redfield, Anuradha Lala, Gregory D. Lewis, Adam D. DeVore, Patrice Desvigne-Nickens, Adrian F. Hernandez, Eugene Braunwald, LIFE Investigators, Selma F. Mohammed, Hellina Birru, Etsubdink Aboye,
Importance The use of sacubitril/valsartan is not endorsed by practice guidelines for use in patients with New York Heart Association class IV heart failure with a reduced ejection fraction because of limited clinical experience in this population. Objective To compare treatment with sacubitril/valsartan treatment with valsartan in patients with advanced heart failure and a reduced ejection fraction
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Assessment of Omecamtiv Mecarbil for the Treatment of Patients With Severe Heart Failure: A Post Hoc Analysis of Data From the GALACTIC-HF Randomized Clinical Trial JAMA Cardiol. (IF 30.154) Pub Date : 2022-01-01 G. Michael Felker, Scott D. Solomon, Brian Claggett, Rafael Diaz, John J. V. McMurray, Marco Metra, Inder Anand, Marisa G. Crespo-Leiro, Ulf Dahlström, Eva Goncalvesova, Jonathan G. Howlett, Peter MacDonald, Alexander Parkhomenko, János Tomcsányi, Siddique A. Abbasi, Stephen B. Heitner, Thomas Hucko, Stuart Kupfer, Fady I. Malik, John R. Teerlink
Importance Heart failure with reduced ejection fraction is a progressive clinical syndrome, and many patients’ condition worsen over time despite treatment. Patients with more severe disease are often intolerant of available medical therapies. Objective To evaluate the efficacy and safety of omecamtiv mecarbil for the treatment of patients with severe heart failure (HF) enrolled in the Global Approach
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Association of Age With the Diagnostic Value of Coronary Artery Calcium Score for Ruling Out Coronary Stenosis in Symptomatic Patients JAMA Cardiol. (IF 30.154) Pub Date : 2022-01-01 Martin Bødtker Mortensen, Sara Gaur, Attila Frimmer, Hans Erik Bøtker, Henrik Toft Sørensen, Kristian Hay Kragholm, Sand Rønnow Niels Peter, Flemming Hald Steffensen, Rebekka Vibjerg Jensen, Michael Mæng, Helle Kanstrup, Michael J. Blaha, Leslee J. Shaw, Omar Dzaye, Jonathon Leipsic, Bjarne Linde Nørgaard, Jesper Møller Jensen
Importance The diagnostic value is unclear of a 0 coronary artery calcium (CAC) score to rule out obstructive coronary artery disease (CAD) and near-term clinical events across different age groups. Objective To assess the diagnostic value of a CAC score of 0 for reducing the likelihood of obstructive CAD and to assess the implications of such a CAC score and obstructive CAD across different age groups
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Association of Smoking With Postprocedural Complications Following Open and Endovascular Interventions for Intermittent Claudication JAMA Cardiol. (IF 30.154) Pub Date : 2022-01-01 Katherine M. Reitz, Andrew D. Althouse, Joseph Meyer, Shipra Arya, Philip P. Goodney, Paula K. Shireman, Daniel E. Hall, Edith Tzeng
Importance Smoking is a key modifiable risk factor in the development and progression of peripheral artery disease, which often manifests as intermittent claudication (IC). Smoking cessation is a first-line therapy for IC, yet a minority of patients quit smoking prior to elective revascularization. Objective To assess if preprocedural smoking is associated with an increased risk of early postprocedural
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Long-term Benefits and Harms Associated With Genetic Cholesteryl Ester Transfer Protein Deficiency in the General Population JAMA Cardiol. (IF 30.154) Pub Date : 2022-01-01 Liv Tybjærg Nordestgaard, Mette Christoffersen, Bo Kobberø Lauridsen, Shoaib Afzal, Børge Grønne Nordestgaard, Ruth Frikke-Schmidt, Anne Tybjærg-Hansen
Importance The balance between the potential long-term clinical benefits and harms associated with genetic cholesteryl ester transfer protein (CETP) deficiency, mimicking pharmacologic CETP inhibition, is unknown. Objective To assess the relative benefits and harms associated with genetic CETP deficiency. Design, Setting, and Participants This study examined 2 similar prospective cohorts of the Danish
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Preterm Delivery and Long-term Risk of Hypertension in Women JAMA Cardiol. (IF 30.154) Pub Date : 2022-01-01 Casey Crump, Jan Sundquist, Kristina Sundquist
Importance Preterm delivery has been associated with future cardiometabolic disorders in women. However, the long-term risks of chronic hypertension associated with preterm delivery and whether such risks are attributable to familial confounding are unclear. Such knowledge is needed to improve long-term risk assessment, clinical monitoring, and cardiovascular prevention strategies in women. Objective
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Analysis of Respiratory Fluoroquinolones and the Risk of Sudden Cardiac Death Among Patients Receiving Hemodialysis JAMA Cardiol. (IF 30.154) Pub Date : 2022-01-01 Magdalene M. Assimon, Patrick H. Pun, Lily (Chin-Hua) Wang, Sana M. Al-Khatib, M. Alan Brookhart, David J. Weber, Wolfgang C. Winkelmayer, Jennifer E. Flythe
Importance Respiratory fluoroquinolone antibiotics are some of the most common medications with QT interval–prolonging potential prescribed to patients with hemodialysis-dependent kidney failure—individuals who have a very high risk of sudden cardiac death (SCD). To date, there have been no large-scale, population-specific studies evaluating the cardiac safety of respiratory fluoroquinolones in the
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Clinical and Functional Characterization of Ryanodine Receptor 2 Variants Implicated in Calcium-Release Deficiency Syndrome JAMA Cardiol. (IF 30.154) Pub Date : 2022-01-01 Thomas M. Roston, Jinhong Wei, Wenting Guo, Yanhui Li, Xiaowei Zhong, Ruiwu Wang, John Paul Estillore, Puck J. Peltenburg, Ferran Rosés I. Noguer, Jan Till, Lee L. Eckhardt, Kate M. Orland, Robert Hamilton, Martin J. LaPage, Andrew D. Krahn, Rafik Tadros, Jeffrey M. Vinocur, Dania Kallas, Sonia Franciosi, Jason D. Roberts, Arthur A. M. Wilde, Henrik K. Jensen, Shubhayan Sanatani, S. R. Wayne Chen
Importance Calcium-release deficiency syndrome (CRDS), which is caused by loss-of-function variants in cardiac ryanodine receptor 2 (RyR2), is an emerging cause of ventricular fibrillation. However, the lack of complex polymorphic/bidirectional ventricular tachyarrhythmias during exercise stress testing (EST) may distinguish it from catecholaminergic polymorphic ventricular tachycardia (CPVT). Recently
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Association of Myocardial Blood Flow Reserve With Adverse Left Ventricular Remodeling in Patients With Aortic Stenosis: The Microvascular Disease in Aortic Stenosis (MIDAS) Study JAMA Cardiol. (IF 30.154) Pub Date : 2022-01-01 Wunan Zhou, Yee-Ping Sun, Sanjay Divakaran, Navkaranbir S. Bajaj, Ankur Gupta, Alvin Chandra, Victoria Morgan, Leanne Barrett, Laurel Martell, Courtney F. Bibbo, Jon Hainer, Eldrin F. Lewis, Viviany R. Taqueti, Sharmila Dorbala, Ron Blankstein, Piotr Slomka, Pinak B. Shah, Tsuyoshi Kaneko, Dale S. Adler, Patrick O’Gara, Marcelo F. Di Carli
Importance Impaired myocardial flow reserve (MFR) and stress myocardial blood flow (MBF) on positron emission tomography (PET) myocardial perfusion imaging may identify adverse myocardial characteristics, including myocardial stress and injury in aortic stenosis (AS). Objective To investigate whether MFR and stress MBF are associated with LV structure and function derangements, and whether these parameters
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A Simplified Method for the Diagnosis of Constrictive Pericarditis in the Cardiac Catheterization Laboratory JAMA Cardiol. (IF 30.154) Pub Date : 2022-01-01 C. Charles Jain, William R. Miranda, Abdallah El Sabbagh, Rick A. Nishimura
Importance Enhanced ventricular interdependence is a highly sensitive and specific criterion for the diagnosis of constrictive pericarditis (CP), but simultaneous ventricular measurements can be challenging at cardiac catheterization. Ejection times (ETs) correlate with stroke volumes and can be easily measured from arterial pressure tracings. Objective To assess respirophasic changes in pulmonary
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Pulmonary Circulation Discovery Before Ibn Nafis—Ancient Persian and Greek Theories: A Narrative Review JAMA Cardiol. (IF 30.154) Pub Date : 2022-01-01 Arman Zargaran
Importance The recognition of the pulmonary circulation is a complex evolution in medical history and draws on theories across eras and cultures. Observations This narrative review summarizes evidence suggesting that the recognition of pulmonary circulation is older than the time of Ibn Nafis. The theory of pulmonary circulation originated in ancient Persia (ad 224-637), was overshadowed by Greek theory
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Error in Figure JAMA Cardiol. (IF 30.154) Pub Date : 2022-01-01
In the Original Investigation titled “Long-term Benefits and Harms Associated With Genetic Cholesteryl Ester Transfer Protein Deficiency in the General Population,”1 published online October 6, 2021, 3 of the 8 bars in the left graph of Figure 4 representing myocardial infarction, age-related macular degeneration (AMD), and dry AMD, respectively, and all 3 bars in the right graph of Figure 4 representing
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Omitted Affiliation JAMA Cardiol. (IF 30.154) Pub Date : 2022-01-01
In the Original Investigation titled “Effect of a Self-care Intervention on 90-Day Outcomes in Patients With Acute Heart Failure Discharged From the Emergency Department: A Randomized Clinical Trial,”1 published in the February 2021 issue, an affiliation was omitted. A second affiliation for Sean P. Collins, MD, MSc, and Jin H. Han, MD, should have been given as “Geriatric Research, Education, and
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JAMA Cardiology JAMA Cardiol. (IF 30.154) Pub Date : 2022-01-01
Mission Statement: JAMA Cardiology publishes exceptional original research, state-of-the-art reviews, and informative opinions that advance the science and practice of cardiology, enhance cardiovascular health, and inform health care policy. JAMA Cardiology is the definitive journal for clinical investigators, clinicians, and trainees in cardiovascular medicine worldwide. JAMA Cardiology focuses on