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CXCL7 enhances RANKL-induced osteoclastogenesis via the activation of ERK/NFATc1 signaling pathway in inflammatory arthritis Arthritis Res. Ther. (IF 4.4) Pub Date : 2025-02-15 Xinyu Wang, Lin Sun, Zhuo An, Changhong Li, Jinxia Zhao
Rheumatoid arthritis (RA) with anti-citrullinated protein/peptide antibodies (ACPA + RA) demonstrates more significant radiographic damage compared to ACPA-negative RA (ACPA- RA). Chemokine-activated signaling pathways contribute to the regulation of the bone formation and resorption. The potential role of C-X-C motif chemokine ligand 7 (CXCL7) in bone erosion and its viability as a therapeutic target
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Pulsed electromagnetic field ameliorates the progression of osteoarthritis via the Sirt1/NF-κB pathway Arthritis Res. Ther. (IF 4.4) Pub Date : 2025-02-14 Siqi Zhou, Haiyan Wen, Xiongwei He, Xiaotao Han, Haohuan Li
Pulsed electromagnetic field (PEMF) is a non-invasive treatment that utilizes electromagnetic fields to reduce inflammation and promote tissue repair. However, PEMFs’ anti-inflammatory effect on osteoarthritis (OA) and the potential mechanism has not been fully elucidated. Human chondrocytes (C28/I2) were stimulated with interleukin (IL)-1β with or without the treatment of PEMF. CCK-8 assay Kit was
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Clinical features and survival analysis of 40 cases of anti-MDA5 antibody-positive dermatomyositis complicated with interstitial lung disease Arthritis Res. Ther. (IF 4.4) Pub Date : 2025-02-13 Kaikai Zhao, Juan Zhang, Qunyu Kong, Yong Zhang, Cong Li, Kaikai Huo, Na Fan, Wenjing Deng, Jie Shi, Chunya Wang, Xueyi Li, Shuanying Yang, Ping Fang
Several studies have shown that patients with anti-MDA5 antibody-positive dermatomyositis (anti-MDA5 antibody + DM) have an increased risk of developing rapid progression of interstitial lung disease (RPILD), which is associated with poor prognosis and high mortality. However, diagnosis and treatment are often delayed due to atypical early clinical features and heterogeneity. Therefore, clinical features
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The conditions that patients with systemic lupus erythematosus should fulfill before pregnancy to optimize outcomes: a large-scale multicenter cohort study from China Arthritis Res. Ther. (IF 4.4) Pub Date : 2025-02-11 Xueyang Zhang, Lingshan Liu, Shudian Lin, Xinwang Duan, Hui Luo, Yongfu Wang, Zhenbiao Wu, Can Huang, Yin Long, Yixin Cui, Xiaohua Shi, Yijun Song, Juntao Liu, Xiaofeng Zeng, Jiuliang Zhao, Mengtao Li, Xinping Tian
Systemic lupus erythematosus (SLE) is frequently associated with a lower rate of live birth and a higher incidence of adverse pregnancy outcomes (APOs), and pregnancy can also increase the risk of SLE flares. Comprehensive preconception assessment is critical for improved pregnancy outcomes in patients with SLE. Unfortunately, no global consensus on the conditions that patients with SLE should fulfill
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Establishment of an ex vivo cartilage damage model by combined collagenase treatment and mechanical loading Arthritis Res. Ther. (IF 4.4) Pub Date : 2025-02-11 Liru Wen, Sibylle Grad, Laura B. Creemers, Martin J. Stoddart
There is a substantial need for ex vivo cartilage damage models to assess new emerging cartilage repair strategies. Ex vivo cartilage explant models have the advantages of achieving standardized and reproducible experimental conditions while maintaining the cells in their native tissue environment. This study aimed to establish a bovine cartilage damage model to evaluate the safety and efficacy of
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Asthma, social isolation and loneliness, and risk of incident osteoarthritis Arthritis Res. Ther. (IF 4.4) Pub Date : 2025-02-10 Ziyi Wu, Xukun Luo, Pengcheng Dou, Tang Liu, Jian Zhou
Incidence of osteoarthritis (OA) was increased in patients with asthma, while no prospective cohort study has tested the association of asthma with OA, and the modified effect of social isolation and loneliness remains unclear. This prospective cohort study included 448,920 participants without OA at baseline from UK Biobank cohort. The evaluation of asthma was based on diagnosis and self-reported
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Proteomic profiling of human plasma and intervertebral disc tissue reveals matrisomal, but not plasma, biomarkers of disc degeneration Arthritis Res. Ther. (IF 4.4) Pub Date : 2025-02-10 Christabel Thembela Dube, Hamish T. J. Gilbert, Niamh Rabbitte, Pauline Baird, Sonal Patel, Jeremy A. Herrera, Ivona Baricevic-Jones, Richard D. Unwin, Danny Chan, Kanna Gnanalingham, Judith A. Hoyland, Stephen M. Richardson
Intervertebral disc (IVD) degeneration is a common cause of low back pain, and the most symptomatic patients with neural compression need surgical intervention to relieve symptoms. Current techniques used to diagnose IVD degeneration, such as magnetic resonance imaging (MRI), do not detect changes in the tissue extracellular matrix (ECM) as degeneration progresses. Improved techniques, such as a combination
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Blood molecular subtypes to guide precision treatment strategies in systemic juvenile idiopathic arthritis Arthritis Res. Ther. (IF 4.4) Pub Date : 2025-02-08 In-Woon Baek, Jung Woo Rhim, Kyung-Su Park, Ki-Jo Kim
Systemic juvenile idiopathic arthritis (sJIA) is the most severe subtype of JIA, with a combination of diverse clinical manifestations and a variable clinical course. A comprehensive understanding of molecular signatures at the systems level and the discovery of molecular subtypes are the initial steps toward personalized medicine in sJIA. A blood transcriptomic dataset was collected from patients
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Integrated analysis of dermatomyositis reveals heterogeneous immune infiltration and interstitial lung disease-associated endotype Arthritis Res. Ther. (IF 4.4) Pub Date : 2025-02-08 Xinzhi Xu, Tianwen Qiu, Kexin Sun, Xue Han, Junxia Huang, Xiuyuan Wang, Jianchao Ge, Ji Yang
Dermatomyositis (DM) is an autoimmune disease with a high rate of disability and mortality especially in DM with concurrent interstitial lung disease (DM-ILD). Little is known about inflammatory signature and heterogeneous endotypes of DM. We aimed to illustrate the systemic inflammatory signature of DM and define an ILD-associated endotype. Olink proteomic analysis was performed on serum samples obtained
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Associations between age, red cell distribution width and 180-day and 1-year mortality in giant cell arteritis patients: mediation analyses and machine learning in a cohort study Arthritis Res. Ther. (IF 4.4) Pub Date : 2025-02-08 Si Chen, Rui Nie, Xiaoran Shen, Yan Wang, Haixia Luan, Xiaoli Zeng, Yanhua Chen, Hui Yuan
The aim of this study was to investigate the correlation between age, red cell distribution width (RDW) levels, and 180-day and 1-year mortality in giant cell arteritis (GCA) patients hospitalized or admitted to the ICU. Clinical data from GCA patients were extracted from the MIMIC-IV (3.0) database. Logistic and Cox regression analyses, Kaplan–Meier (KM) survival analysis, restricted cubic spline
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The rational use of glucocorticoids may reduce the risk of readmission in menopausal women with knee osteoarthritis: results from a five-year longitudinal study Arthritis Res. Ther. (IF 4.4) Pub Date : 2025-02-06 Huang Xi, Hao Huiqin, Liu Hongqi, Zhang Ruqi, Zhang Junfeng
To investigate the effect of glucocorticoids (GCs) on the risk of readmission in menopausal women with knee osteoarthritis (OA). The study cohort comprised 80 menopausal women with knee OA treated at a tertiary hospital affiliated with Shanxi Medical University and who underwent follow-up between September 2018 and September 2023. Then the collected longitudinal monitoring data were used to construct
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Upadacitinib in active non-radiographic axial spondyloarthritis: 2-year data from the phase 3 SELECT-AXIS 2 study Arthritis Res. Ther. (IF 4.4) Pub Date : 2025-02-04 Filip Van den Bosch, Atul Deodhar, Denis Poddubnyy, Walter P. Maksymowych, Désirée van der Heijde, Tae-Hwan Kim, Mitsumasa Kishimoto, Xenofon Baraliakos, Xianwei Bu, Ivan Lagunes-Galindo, In-Ho Song, Peter Wung, Koji Kato, Anna Shmagel
In SELECT-AXIS 2, upadacitinib improved the signs and symptoms of active non-radiographic axial spondyloarthritis (nr-axSpA) through 52 weeks versus placebo and was well tolerated. Here, we evaluated the efficacy and safety of upadacitinib through 2 years. The study enrolled eligible adult patients with a clinical diagnosis of nr-axSpA who met the 2009 Assessment of SpondyloArthritis international
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Long-term outcome of a treat-to-target strategy in late-onset rheumatoid arthritis with chronic lung disease: 5-year results of a prospective observational study Arthritis Res. Ther. (IF 4.4) Pub Date : 2025-02-03 Manami Nomura, Takahiko Sugihara, Hiroyuki Baba, Tadashi Hosoya, Mari Kamiya, Tatsuro Ishizaki, Takumi Matsumoto, Kanae Kubo, Fumio Hirano, Masayo Kojima, Nobuyuki Miyasaka, Shinsuke Yasuda, Masayoshi Harigai
Controlling disease activity and improving physical function would be more difficult in patients with late-onset rheumatoid arthritis (LORA) who have chronic lung disease (CLD) at baseline. Our aim was to evaluate 5-year outcomes of following a treat-to-target (T2T) strategy targeting low disease activity (LDA) in LORA with CLD. Data from 197 methotrexate (MTX)-naïve LORA patients (mean age 74.4 years)
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MiR-223 within neutrophil axis promotes Th17 expansion by PI3K-AKT pathway in systemic lupus erythematosus Arthritis Res. Ther. (IF 4.4) Pub Date : 2025-02-03 Chengzhong Zhang, Yan Lu
Further investigation is required to determine the etiology of systemic lupus erythematosus (SLE). The aim of this study is to assess the presence of miR-223 within neutrophils in SLE and investigate its impact on the expansion of Th17 cells. Experiments were performed in MRL/lpr mice, which were divided into control and miR-223 knockdown (miR-223-) group. We assessed miR-223 expression within neutrophils
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Predicting abatacept retention using machine learning Arthritis Res. Ther. (IF 4.4) Pub Date : 2025-02-01 Rieke Alten, Claire Behar, Pierre Merckaert, Ebenezer Afari, Virginie Vannier-Moreau, Anael Ohayon, Sean E. Connolly, Aurélie Najm, Pierre-Antoine Juge, Gengyuan Liu, Angshu Rai, Yedid Elbez, Karissa Lozenski
The incorporation of machine learning is becoming more prevalent in the clinical setting. By predicting clinical outcomes, machine learning can provide clinicians with a valuable tool for refining precision medicine approaches and improving treatment outcomes. This was a post hoc analysis of pooled patient-level data from the global, real-world ACTION and ASCORE trials in patients with rheumatoid arthritis
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Performance of the modified 2022 ACR/EULAR giant cell arteritis classification criteria without age restriction for discriminating from Takayasu arteritis Arthritis Res. Ther. (IF 4.4) Pub Date : 2025-01-31 Takahiko Sugihara, Masayoshi Harigai, Haruhito A. Uchida, Hajime Yoshifuji, Yasuhiro Maejima, Jun Ishizaki, Yoshiko Watanabe, Hiroaki Dobashi, Yoshinori Komagata, Naoto Tamura, Yoshikazu Nakaoka
To evaluate the ability to discriminate giant cell arteritis (GCA) from Takayasu arteritis (TAK) according to the modified 2022 American College of Rheumatology/European Alliance of Associations for Rheumatology (ACR/EULAR) GCA classification criteria. Patients enrolled in the Japanese nationwide retrospective registry were evaluated using the criteria with partial modification; wall thickening of
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Differences in the response to TNF inhibitors at distinct joint locations in patients with psoriatic arthritis: results from nine European registries Arthritis Res. Ther. (IF 4.4) Pub Date : 2025-01-31 Adrian Ciurea, Seraphina Kissling, Andrea Götschi, Lykke Midtbøll Ørnbjerg, Simon Horskjær Rasmussen, Bálint Tamási, Burkhard Möller, Michael J. Nissen, Bente Glintborg, Anne Gitte Loft, Almut Scherer, René Bräm, Karel Pavelka, Jakub Závada, Joao Madruga Dias, Paula Valente, Bjorn Gudbjornsson, Olafur Palsson, Vappu Rantalaiho, Ritva Peltomaa, Catalin Codreanu, Corina Mogosan, Florenzo Iannone, Marco
Efficacy of tumour necrosis factor inhibitors (TNFi) for peripheral arthritis in patients with psoriatic arthritis (PsA) has been established in randomized clinical trials that have used improvement in summated joint counts as an outcome. Whether joints at different anatomical locations might respond differentially to TNFi remains unknown. The aim of the study was to investigate potential variations
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Diagnostic performance of optical spectral transmission compared to magnetic resonance imaging in patients with inflammatory arthritis Arthritis Res. Ther. (IF 4.4) Pub Date : 2025-01-30 Konstantinos Triantafyllias, Mohammed Alhaddad, Andreas Schwarting, Veronika Balaklytska, Xenofon Baraliakos
Optical spectral transmission (OST) is a modern diagnostic method capable of quantifying inflammation in the finger and wrist joints of arthritis patients by assessing the blood-specific absorption of light transmitted through a tissue. The diagnostic performance of this modality has not been adequately examined and data regarding OST associations with magnetic resonance imaging (MRI) are limited.
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GPIHBP1 increase accounts for rheumatic arthritis-related hypotriglyceridemia by facilitating lipids uptake of white adipose tissues Arthritis Res. Ther. (IF 4.4) Pub Date : 2025-01-25 Meng-Ke Song, Meng-Fan Gu, Ling Liu, Lian-Jun He, Peng Ye, Kui Yang, Dan-Dan Wang, Opeyemi Joshua Olatunji, Qin Yin, Jian Zuo
Metabolism alteration is a common complication of rheumatic arthritis (RA). This work investigated the reason behind RA-caused triglyceride (TG) changes. Fresh RA patients’ whole blood was transfused into NOD-SCID mice. Metabolism-regulatory tissues were examined after sacrifice. To verify the findings, tissues of the rats with long-lasting adjuvant-induced arthritis (AIA) were analyzed. Some rats
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Exploring the therapeutic effect of human recombinant IL11 on lesioned OA human osteochondral explants Arthritis Res. Ther. (IF 4.4) Pub Date : 2025-01-24 Margo Tuerlings, Evelyn Houtman, Elisa J.H. Muusers, Janneke Simon, Maurice W. de Haan, Ilja Boone, Yolande F.M. Ramos, Rachid Mahdad, Ingrid Meulenbelt
To explore IL11 co-expression profiles in our previously reported RNA-sequencing dataset of OA articular cartilage, in interaction with IL6, and to investigate the effects of hrIL11 administration as potential therapeutic strategy for OA articular cartilage using our biomimetic aged human osteochondral explant model of OA. We used RNA-sequencing datasets of macroscopically preserved and lesioned OA
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Cancer incidence and the influence of immunosuppressive agents in Korean patients with systemic lupus erythematosus: a retrospective cohort study Arthritis Res. Ther. (IF 4.4) Pub Date : 2025-01-22 Soo-Kyung Cho, Jung-Yong Han, Yena Jeon, Seung-Hun You, Sun-Young Jung, Eun Jin Jang, Yoon-Kyoung Sung
To investigate cancer incidence and the potential influence of immunosuppressive agents in Korean systemic lupus erythematosus (SLE) patients. We conducted a retrospective analysis utilizing data from the Korea Healthcare Bigdata Linked Platform, which integrated the National Central Cancer Registry and National Health Insurance Service databases covering the period 2008–2017. Incidence rates (IRs)
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Do individuals with inflammatory arthritis receive minimally adequate treatment for incident depression and anxiety: A population-based study Arthritis Res. Ther. (IF 4.4) Pub Date : 2025-01-21 Alyssa Howren, Eric C. Sayre, J. Antonio Avina-Zubieta, Joseph H. Puyat, Deborah Da Costa, Hui Xie, Eileen Davidson, Amit Gupta, Mary A. De Vera
Describe patterns of pharmacotherapy and psychological treatment and evaluate receipt of minimally adequate treatment for incident depression and anxiety in individuals with inflammatory arthritis (IA). We used population-based linked administrative health databases from British Columbia, Canada to evaluate pharmacotherapy and psychological treatments for incident depression and/or anxiety among individuals
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Suberosin attenuates rheumatoid arthritis by repolarizing macrophages and inhibiting synovitis via the JAK/STAT signaling pathway Arthritis Res. Ther. (IF 4.4) Pub Date : 2025-01-21 Huan Liu, Qianwei Li, Yuehong Chen, Min Dong, Hongjiang Liu, Jiaqian Zhang, Leiyi Yang, Geng Yin, Qibing Xie
Rheumatoid arthritis (RA) is a systemic disease that primarily manifests as chronic synovitis of the symmetric small joints. Despite the availability of various targeted drugs for RA, these treatments are limited by adverse reactions, warranting new treatment approaches. Suberosin (SBR), isolated from Plumbago zeylanica—a medicinal plant traditionally used to treat RA in Asia—possesses notable biological
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Exosome miR-199a-5p modulated vascular remodeling and inflammatory infiltration of Takayasu’s arteritis Arthritis Res. Ther. (IF 4.4) Pub Date : 2025-01-20 Shuning Guo, Jiehan Li, Shurui Pang, Jing Li, Xinping Tian
Advances in treatment have swiftly alleviated systemic inflammation of Takayasu’s arteritis (TAK), while subclinical vascular inflammation and the ensuing arterial remodeling continue to present unresolved challenges in TAK. The phenotypic switching of vascular smooth muscle cells (VSMC) is regarded as the first step in vascular pathology and contributes to arterial remodeling. Exosomes facilitate
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The serum level of sclerostin decreases in radiographic axial spondyloarthritis patients with fatty lesions Arthritis Res. Ther. (IF 4.4) Pub Date : 2025-01-16 Xuegang Li, Haijian Jiang, Xu Wang, Shuping Zhong
Currently, the pathophysiology of new bone formation in radiographic axial spondyloarthritis (r-axSpA) remains unclear. Cellular elements and their secreted bone turnover markers might be one of the underlying mechanisms that drive the new bone formation. Our study aimed to investigate the role of bone turnover markers in r-axSpA patients with fatty lesions. 73 r-axSpA patients were enrolled in this
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The role of Anti-PAD4, Anti-CarP, and Anti-RA33 antibodies combined with RF and ACPA in predicting abatacept response in rheumatoid arthritis Arthritis Res. Ther. (IF 4.4) Pub Date : 2025-01-15 Alberto Floris, Maria Maddalena Angioni, Mattia Fadda, Micaela Rita Naitza, Mattia Congia, Elisabetta Chessa, Matteo Piga, Alberto Cauli
To explore the role of newly emerging autoantibodies (AAbs) - peptidyl-arginine deiminase 4 (aPAD4), carbamylated proteins (aCarP), and anti-RA33 (aRA33) - alongside the traditionally assessed rheumatoid factor (RF) and anti-citrullinated protein antibodies (ACPA), in predicting the response to abatacept (ABT) and its retention rate in rheumatoid arthritis (RA) patients. Data from 121 consecutive ABT-treated
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Distribution of spinal damage in patients with axial spondyloarthritis as assessed by MRI: a prospective and blinded study Arthritis Res. Ther. (IF 4.4) Pub Date : 2025-01-14 Andreas Haidmayer, Gabriel Adelsmayr, Christopher Spreizer, Eva Valentina Klocker, Franz Quehenberger, Michael Fuchsjaeger, Jens Thiel, Josef Hermann
Axial spondyloarthritis (SpA) leads to structural bone lesions in every part of the vertebral column. These lesions are only partially visualized on conventional radiographs, omitting posterior parts of the vertebral column and the thoracic spine, that may nevertheless contribute to impaired spinal mobility and function in patients with axial SpA. In this prospective and blinded investigation, we assessed
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Eltrombopag for the treatment of refractory connective tissue disease-related thrombocytopenia: a pilot study of 52 cases Arthritis Res. Ther. (IF 4.4) Pub Date : 2025-01-10 Siying Deng, Bei Wang, Ziwei Hu, Shaozhe Cai, Lingli Dong
The objective of this study was to investigate the therapeutic effectiveness and safety profile of Eltrombopag, a thrombopoietin receptor agonist, as prolonged therapy in refractory CTD-ITP patients. We conducted a pilot observational study of Eltrombopag in CTD-ITP patients who were unresponsive to or intolerant of conventional medications. Eltrombopag was administered orally at 25–75 mg/qd and adjusted
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Inhibition of macrophage polarization and pyroptosis in collagen-induced arthritis through MSC-exo and ginsenoside Rh2 Arthritis Res. Ther. (IF 4.4) Pub Date : 2025-01-09 Zhongsheng Zhou, Shuhui Wu, Yang Li, Pu Shao, Jinlan Jiang
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by joint inflammation, tissue damage, and fibrosis, significantly affecting the quality of life. While there are currently some effective treatments available, they often come with side effects. There is an urgent need to find new treatments that can further improve therapeutic outcomes and reduce side effects. Our study investigates
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Disease activity in patients with idiopathic inflammatory myopathy according to time since diagnosis and positivity to antisynthetase autoantibodies: data from the Myo-Spain registry Arthritis Res. Ther. (IF 4.4) Pub Date : 2025-01-08 Tatiana Cobo-Ibáñez, Ivan Castellví, Ana Pros, Marta Domínguez-Álvaro, Laura Nuño-Nuño, Julia Martínez-Barrio, Vega Jovaní, Fredeswinda Romero-Bueno, Esther Ruiz-Lucea, Eva Tomero, Ernesto Trallero-Araguás, Javier Narváez, Jordi Camins-Fàbregas, Alberto Ruiz-Román, Jesús Loarce-Martos, Susana Holgado-Pérez, V Miguel Flores-Rodríguez, Francisca Sivera, Carolina Merino-Argumanez, Antonio Juan-Mas, Irene
To evaluate the main outcomes of disease activity and their association with other measures of activity, damage, and quality of life in patients with idiopathic inflammatory myopathy (IIM) according to time since diagnosis and positivity to antisynthetase autoantibodies (ASAs). Cross-sectional multicenter study within the Spanish Myo-Spain registry. Cases were classified as incident (≤ 12 months since
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Mortality in patients with giant cell arteritis in Spain: results from the ARTESER registry Arthritis Res. Ther. (IF 4.4) Pub Date : 2025-01-07 Juan Molina-Collada, Marta Domínguez-Álvaro, Rafael B. Melero-González, Eugenio de Miguel, Maite Silva-Díaz, Jesús Alejandro Valero Jaimes, Ismael González, Julio Sánchez Martín, Javier Narváez, Joan Calvet, Ivette Casafont-Solé, Jose A Román Ivorra, Selene Labrada Arrabal, Margarida Vasques Rocha, Carlota L Iñiguez, María Sagrario Bustabad Reyes, Cristina Campos Fernández, María Alcalde Villar, Antonio
To compare mortality rates between GCA patients and the general population in Spain, and to identify associated factors influencing mortality. ARTESER, a multicenter registry by the Spanish Society of Rheumatology, includes GCA patients from June 2013 to March 2019. Demographic, clinical, imaging, histological and mortality data were collected retrospectively. Only patients with at least one year of
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Gastrointestinal lesions of eosinophilic granulomatosis with polyangiitis: a prediction model and clinical patterns Arthritis Res. Ther. (IF 4.4) Pub Date : 2025-01-04 Suying Liu, Yunjiao Yang, Linna Han, Chengmei He, Mengtao Li, Xinping Tian, Juan Meng, Li Wang, Fengchun Zhang
Severe gastrointestinal lesions are associated with a poor prognosis in eosinophilic granulomatosis with polyangiitis (EGPA). The goal of this study was to develop an effective predictive model for gastrointestinal lesions and to examine clinical patterns, associated factors, treatment, and outcomes of gastrointestinal lesions in EGPA. We retrospectively enrolled 165 EGPA patients. The independent
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Obesity and fibromyalgia are associated with Difficult-to-Treat Rheumatoid Arthritis (D2T-RA) independent of age and gender Arthritis Res. Ther. (IF 4.4) Pub Date : 2025-01-03 Nicoletta Luciano, Elisa Barone, Enrico Brunetta, Alessio D’Isanto, Maria De Santis, Angela Ceribelli, Marta Caprioli, Giacomo M. Guidelli, Daniela Renna, Carlo Selmi
There is still a significant proportion of patients with rheumatoid arthritis (RA) in whom multiple therapeutic lines are ineffective. These cases are defined by the EULAR criteria as Difficult-to-Treat RA (D2T-RA) for which there is limited knowledge of predisposing factors. To identify the clinical features associated with D2T-RA in real-life practice. We retrospectively collected demographic, clinical
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Predicting autoimmune thyroiditis in primary Sjogren’s syndrome patients using a random forest classifier: a retrospective study Arthritis Res. Ther. (IF 4.4) Pub Date : 2025-01-02 Jia-yun Wu, Jing-yu Zhang, Wen-qi Xia, Yue-ning Kang, Ru-yi Liao, Yu-ling Chen, Xiao-min Li, Ya Wen, Fan-xuan Meng, Li-ling Xu, Sheng-hui Wen, Hui-fen Liu, Yuan-qing Li, Jie-ruo Gu, Qing Lv, Yong Ren
Primary Sjogren’s syndrome (pSS) and autoimmune thyroiditis (AIT) share overlapping genetic and immunological profiles. This retrospective study evaluates the efficacy of machine learning algorithms, with a focus on the Random Forest Classifier, to predict the presence of thyroid-specific autoantibodies (TPOAb and TgAb) in pSS patients. A total of 96 patients with pSS were included in the retrospective
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Comparative analysis of arterial involvement in predominant cranial and isolated extracranial phenotypes of giant cell arteritis using 18F-FDG PET-CT Arthritis Res. Ther. (IF 4.4) Pub Date : 2024-12-28 Javier Narvaez, Paola Vidal-Montal, Iván Sánchez-Rodríguez, Aida Sabaté-Llobera, Montserrat Cortés-Romera, Judith Palacios-Olid, Pol Maymó-Paituvi, Joan Miquel Nolla
To investigate differences in arterial involvement patterns on 18F-FDG PET-CT between predominant cranial and isolated extracranial phenotypes of giant cell arteritis (GCA). A retrospective review of 18F-FDG PET-CT findings was conducted on 140 patients with confirmed GCA. The patients were divided into two groups: the cranial group, which presented craniofacial ischemic symptoms either at diagnosis
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Risk prediction of new-onset thrombocytopenia in patients with systemic lupus erythematosus: a multicenter prospective cohort study based on Chinese SLE treatment and research group (CSTAR) registry Arthritis Res. Ther. (IF 4.4) Pub Date : 2024-12-27 Yupei Zhang, Nan Jiang, Xinwang Duan, Jian Xu, Lijun Wu, Wei Wei, Weiguo Xiao, Li Luo, Zhenyu Jiang, Yanhong Wang, Jiuliang Zhao, Qian Wang, Xinping Tian, Mengtao Li, Xiaofeng Zeng
Thrombocytopenia (TP) is a hematological manifestation of systemic lupus erythematosus (SLE) and is associated with unfavorable prognostic outcomes. This study aimed to develop a risk prediction model for new-onset TP in SLE patients. Based on the multicenter prospective Chinese SLE Treatment and Research Group (CSTAR) registry, newly diagnosed SLE patients without TP at registration were enrolled
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High leptin levels in blood are associated with chronic widespread pain in rheumatoid arthritis Arthritis Res. Ther. (IF 4.4) Pub Date : 2024-12-23 M. Aronsson, S. Bergman, E. Lindqvist, M. L. E. Andersson
High body mass index (BMI) has been shown to have an association with chronic widespread pain (CWP), both in Rheumatoid arthritis (RA) and in other pain conditions such as fibromyalgia. Research on the adipose tissue and it’s adipokines, for example the well described leptin, is emerging. The objective of this study was to determine if there is an association between leptin levels in blood and CWP
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Integrative metabolomic-proteomic analysis uncovers a new therapeutic approach in targeting rheumatoid arthritis Arthritis Res. Ther. (IF 4.4) Pub Date : 2024-12-23 Prachi Agnihotri, Mohd Saquib, Lovely Joshi, Swati Malik, Debolina Chakraborty, Ashish Sarkar, Uma Kumar, Sagarika Biswas
Rheumatoid arthritis (RA) is a chronic inflammatory condition that, despite available approaches to manage the disease, lacks an efficient treatment and timely diagnosis. Using the most advanced omics technique, metabolomics and proteomics approach, we explored varied metabolites and proteins to identify unique metabolite-protein signatures involved in the disease pathogenesis of RA. Untargeted metabolomics
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The comprehensive relationship between combined anti-inflammatory and healthy diets and all-cause mortality in rheumatoid arthritis: results from NHANES 2003–2018 Arthritis Res. Ther. (IF 4.4) Pub Date : 2024-12-23 Penghe Wang, Dongni Wang, Jiayu Sui, Shuang Liu, Yingjing Kong, Hongwei Lei, Maomao Zhang
Rheumatoid arthritis (RA) is a chronic, systemic autoimmune inflammatory disorder. Diet is recognized as a modifiable factor that may influence inflammation and potentially accelerate RA progression. Nevertheless, the effects of diverse dietary patterns and their combined impact on RA progression and long-term mortality remain inadequately understood. This study examined the association between dietary
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Comparing immunogenicity and safety following transition from reference rituximab to biosimilar rituximab (DRL_RI) in patients with rheumatoid arthritis: a randomized, double-blind, phase 3 study Arthritis Res. Ther. (IF 4.4) Pub Date : 2024-12-21 Narendra Maharaj, Dharma Rao Uppada, Naveen Reddy, Pramod Reddy, Anastas Batalov, Delina lvanova, Nedyalka Staykova, Asta Baranauskaite, Laila Amirali Hassan
To assess immunogenicity and safety in patients with active rheumatoid arthritis (RA) transitioning from rituximab [US-licensed rituximab: Reference Product (RP); EU-approved rituximab: Reference Medicinal Product (RMP)] to DRL_RI (proposed rituximab biosimilar), in comparison to those continuing on RP/RMP. This double-blind, randomized, Phase 3 study included 140 RA patients having prior exposure
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Acute systemic macrophage depletion in osteoarthritic mice alleviates pain-related behaviors and does not affect joint damage Arthritis Res. Ther. (IF 4.4) Pub Date : 2024-12-20 Terese Geraghty, Shingo Ishihara, Alia M. Obeidat, Natalie S. Adamczyk, Rahel S. Hunter, Jun Li, Lai Wang, Hoomin Lee, Frank C. Ko, Anne-Marie Malfait, Rachel E. Miller
Osteoarthritis (OA) is a painful degenerative joint disease and a leading source of years lived with disability globally due to inadequate treatment options. Neuroimmune interactions reportedly contribute to OA pain pathogenesis. Notably, in rodents, macrophages in the DRG are associated with onset of persistent OA pain. Our objective was to determine the effects of acute systemic macrophage depletion
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Integrated bioinformatic analysis of the shared molecular mechanisms between ANCA-associated vasculitis and atherosclerosis Arthritis Res. Ther. (IF 4.4) Pub Date : 2024-12-19 Xun Hu, Inmaculada Xu Lou, Qilan Chen
Accumulated evidence supports the tendency of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis(AAV) to coexist with atherosclerosis (AS). However, the common etiology of these two diseases remains unclear. This study aims to explore the mechanisms underlying the concurrent occurrence of ANCA and AS. Microarray data of AAV and AS were examined in a comprehensive gene expression database
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KLF2 controls the apoptosis of neutrophils and is associated with disease activity of systemic lupus erythematosus Arthritis Res. Ther. (IF 4.4) Pub Date : 2024-12-19 Hongshuai Zhao, Zaichuan Lin, Peiwen Zhang, Jiayue Rao, Shumin Xu, Qing Luo, Junming Li
Neutropenia is more common in patients with systemic lupus erythematosus (SLE) and is a major cause of life-threatening infections. The increased apoptosis of neutrophils is likely to be an essential cause of neutropenia in SLE. However, the detailed mechanisms of increased neutrophil apoptosis in SLE remain unknown. This study focused on the role of Krüppel-like factor 2 (KLF2) in the regulation of
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Poor prognostic factors for relapse of interstitial lung disease in microscopic polyangiitis: the Japanese multicentre REVEAL cohort study Arthritis Res. Ther. (IF 4.4) Pub Date : 2024-12-19 Shogo Matsuda, Takuya Kotani, Ayana Okazaki, Daisuke Nishioka, Yuichi Masuda, Mayu Shiomi, Ryu Watanabe, Tomoki Taniguchi, Atsushi Manabe, Keiichiro Kadoba, Tsuneyasu Yoshida, Ryosuke Hiwa, Wataru Yamamoto, Motomu Hashimoto, Tohru Takeuchi
This study investigated poor prognostic factors for the relapse of interstitial lung disease (ILD) in patients with microscopic polyangiitis (MPA) after remission induction therapy. We enrolled patients diagnosed with MPA complicated by ILD according to the Chapel Hill Consensus definition from 2001 to 2023 in multiple institutions in the REVEAL cohort. All patients who were treated with immunosuppressive
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Neutrophil extracellular traps and oxidative stress in systemic lupus erythematosus patients with and without renal involvement Arthritis Res. Ther. (IF 4.4) Pub Date : 2024-12-19 Lu Liu, Karina de Leeuw, Harry van Goor, Berber Doornbos-van der Meer, Suzanne Arends, Johanna Westra
To investigate the levels of plasma neutrophil extracellular traps (NETs) and free thiols, the latter reflecting systemic oxidative stress (OS), and to explore the relationship between NETs and OS in quiescent systemic lupus erythematosus (SLE) patients with and without renal involvement. Plasma levels of NETs and free thiols were measured cross-sectionally in 100 SLE patients with low disease activity
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Quantitative 18F-FDG PET-CT can assess presence and extent of interstitial lung disease in early severe diffuse cutaneous systemic sclerosis Arthritis Res. Ther. (IF 4.4) Pub Date : 2024-12-19 Bo Broens, Esther J. Nossent, Lilian J. Meijboom, Gerben J. C. Zwezerijnen, Julia Spierings, Jeska K. de Vries-Bouwstra, Jacob M. van Laar, Conny J. van der Laken, Alexandre E. Voskuyl
This study aimed to assess the quantitative uptake of 18F-FDG PET-CT in the lungs of patients with early severe diffuse cutaneous systemic sclerosis (SSc) with and without interstitial lung disease (ILD), compared to controls. In patients with SSc-ILD, 18F-FDG uptake was correlated to high-resolution computed tomography (HRCT) and pulmonary function test (PFT) parameters. A prospective, cross-sectional
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Efficacy and safety of tofacitinib in an open-label, long-term extension study in patients with psoriatic arthritis who received adalimumab or tofacitinib in a Phase 3 randomized controlled study: a post hoc analysis Arthritis Res. Ther. (IF 4.4) Pub Date : 2024-12-19 Dafna D. Gladman, Peter Nash, Philip J. Mease, Oliver FitzGerald, Stephanie Duench, Mary Jane Cadatal, Karim R. Masri
Data on treatment switching directly from tumor necrosis factor inhibitors to tofacitinib in psoriatic arthritis (PsA) are limited. This post hoc analysis assessed efficacy and safety outcomes in patients with PsA who directly switched to tofacitinib in a long-term extension (LTE) study after receiving adalimumab (ADA) in a Phase 3 study, compared with those who continued to receive tofacitinib. Patients
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A non-invasive model for diagnosis of primary Sjogren’s disease based on salivary biomarkers, serum autoantibodies, and Schirmer’s test Arthritis Res. Ther. (IF 4.4) Pub Date : 2024-12-19 Xinwei Zhang, Zhangdi Liao, Yangchun Chen, Huiqin Lu, Aodi Wang, Yingying Shi, Qi Zhang, Ying Wang, Yan Li, Jingying Lan, Chubing Chen, Chaoqiong Deng, Wuwei Zhuang, Lingyu Liu, Hongyan Qian, Shiju Chen, Zhibin Li, Guixiu Shi, Yuan Liu
Minor salivary gland (MSG) biopsy is a critical but invasive method for the classification of primary Sjögren’s disease (pSjD). Here we aimed to identify salivary proteins as potential biomarkers and to establish a non-invasive prediction model for pSjD. Liquid chromatography-tandem mass spectrometry was conducted on whole saliva samples from patients with pSjD and non-Sjögren control subjects (non-pSjD)
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Therapeutic potential of antibody-drug conjugates possessing bifunctional anti-inflammatory action in the pathogenies of rheumatoid arthritis Arthritis Res. Ther. (IF 4.4) Pub Date : 2024-12-19 Tanu Dixit, Anuradha Vaidya, Selvan Ravindran
In an age where there is a remarkable upsurge in developing precision medicines, antibody-drug conjugates (ADCs) have emerged as a progressive therapeutic strategy. ADCs typically consist of monoclonal antibodies (mAb) conjugated to the cytotoxic payloads by utilizing a linker, combining the benefits of definitive target specificity of mAbs and potent killing impact of payload to achieve precise and
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Development of differential diagnostic models for distinguishing between limb-girdle muscular dystrophy and idiopathic inflammatory myopathy Arthritis Res. Ther. (IF 4.4) Pub Date : 2024-12-19 Guangyu Wang, Lijun Fu, Lining Zhang, Kai Shao, Ying Hou, Tingjun Dai, Pengfei Lin, Chuanzhu Yan, Bing Zhao
Limb-girdle muscular dystrophy (LGMD) is usually confused with idiopathic inflammatory myopathy (IIM) in clinical practice. Our study aimed to establish convenient and reliable diagnostic models for distinguishing between LGMD and IIM. A total of 71 IIM patients, 24 LGMDR2 patients and 22 LGMDR1 patients diagnosed at our neuromuscular center were enrolled. Differences in clinical, laboratory and histopathological
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Proteoglycan 4 (Lubricin) and regulation of xanthine oxidase in synovial macrophage as a mechanism of controlling synovitis Arthritis Res. Ther. (IF 4.4) Pub Date : 2024-12-19 Khaled A. Elsaid, Ling X. Zhang, Thomas Zhao, Ava Marks, Derek Jenkins, Tannin A. Schmidt, Gregory D. Jay
Synovial macrophages (SMs) are important effectors of joint health and disease. A novel Cx3CR1 + TREM2 + SM population expressing the tight junction protein claudin-5, was recently discovered in synovial lining. Ablation of these SMs was associated with onset of arthritis. Proteoglycan 4 (PRG4) is a mucinous glycoprotein that fulfills lubricating and homeostatic roles in the joint. The aim of this
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XGBoost-SHAP-based interpretable diagnostic framework for knee osteoarthritis: a population-based retrospective cohort study Arthritis Res. Ther. (IF 4.4) Pub Date : 2024-12-19 Zijuan Fan, Wenzhu Song, Yan Ke, Ligan Jia, Songyan Li, Jiao Jiao Li, Yuqing Zhang, Jianhao Lin, Bin Wang
To use routine demographic and clinical data to develop an interpretable individual-level machine learning (ML) model to diagnose knee osteoarthritis (KOA) and to identify highly ranked features. In this retrospective, population-based cohort study, anonymized questionnaire data was retrieved from the Wu Chuan KOA Study, Inner Mongolia, China. After feature selections, participants were divided in
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Role of TLR4 activation and signaling in bone remodeling, and afferent sprouting in serum transfer arthritis Arthritis Res. Ther. (IF 4.4) Pub Date : 2024-12-18 Gilson Goncalves dos Santos, Juan Miguel Jiménez-Andrade, Enriqueta Muñoz-Islas, Mariana E. Candanedo-Quiroz, Andrea Gonzalez Cardenas, Bronwen Drummond, Peter Pham, Gwendalynn Stilson, Chao-Chin Hsu, Lauriane Delay, Juliana M. Navia-Pelaez, Julia Paes Lemes, Yury I. Miller, Tony L. Yaksh, Maripat Corr
In the murine K/BxN serum transfer rheumatoid arthritis (RA) model, tactile allodynia persists after resolution of inflammation in male and partially in female wild type (WT) mice, which is absent in Toll-like receptor (TLR)4 deficient animals. We assessed the role of TLR4 on allodynia, bone remodeling and afferent sprouting in this model of arthritis. K/BxN sera were injected into male and female
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Immunological effects of CD19.CAR-T cell therapy in systemic sclerosis: an extended case study Arthritis Res. Ther. (IF 4.4) Pub Date : 2024-12-13 Maren Claus, Merle Freitag, Meike Ewald, Lea Rodon, Franca Deicher, Carsten Watzl, Philipp Kolb, Hanns-Martin Lorenz, Michael Schmitt, Wolfgang Merkt
The high potential of CD19.CAR-T cells to treat autoimmune diseases such as Systemic Sclerosis (SSc) supposedly relies on the disappearance of autoantibodies. Here we investigated effects of CAR-T cells on the innate immune system which is an important contributor to pathology in SSc. Longitudinal analysis of peripheral blood mononuclear cells from an Scl70 + SSc patient treated with CAR-T cells sampled
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Clonal T cell populations scarcely impair patients with rheumatic diseases: a prospective long-term follow up study Arthritis Res. Ther. (IF 4.4) Pub Date : 2024-12-11 Michael Gernert, Tobias Müller, Lukas Schweiker, Marc Schmalzing, Matthias Fröhlich, Lea-Kristin Nagler, Patrick-Pascal Strunz, Hannah Labinsky, Eva Christina Schwaneck
Clonal T cell populations are frequently detected in patients with rheumatic diseases. The relevance of this finding is often uncertain, as the clinical spectrum can range from being asymptomatic to T cell leukemia. Former studies suggested that certain anti-rheumatic drugs might influence the course of the clonal T cell populations. A prospective long-term follow up study was performed including patients
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Impact of systemic inflammation and disease activity on the incidence of interstitial lung disease in patients with rheumatoid arthritis – a nested case-control study within the German biologics register RABBIT Arthritis Res. Ther. (IF 4.4) Pub Date : 2024-12-05 Ronja Ramien, Tatjana Rudi, Rieke Alten, Andreas Krause, Matthias Schneider, Martin Schaefer, Anja Strangfeld, Yvette Meissner
To investigate the association between the development of incident interstitial lung disease (ILD) in patients with rheumatoid arthritis (RA) and the disease activity of RA with its various components, especially C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR). We analysed data from RA patients, observed in the German biologics register RABBIT between 2001 and 2021. In a nested case-control
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Impact of the digital health application ViViRA on spinal mobility, physical function, quality of life and pain perception in spondyloarthritides patients: a randomized controlled trial Arthritis Res. Ther. (IF 4.4) Pub Date : 2024-12-03 Paloma Palm von Alten Blaskowitz, Anna-Maria Liphardt, Claudia Bouzas, Birte Coppers, Pascal Petit, Nicolas Vuillerme, Vanessa Bundle, Sebastian Rudolf, Johannes Knitza, Maria Gabriella Raimondo, Hannah Labinsky, Lukas Hatscher, Andreas Wirsching, Daniela Bohr, Elizabeth Araujo, Andreas Ramming, Alina Ramming, Georg Schett, Harriet Morf
Spondyloarthritides (SpAs) are a group of common rheumatic diseases that often cause limited mobility and lower back pain. Physiotherapy is an integral part of treatment, but access to physiotherapy limits treatment success. Digital health applications (DHAs) enable home-based physiotherapy and could significantly improve access for SpAs patients. The aim is to investigate the clinical effects of the
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Genetically predicted metabolite mediates the causal relationship between immune cells and autoimmune diseases Arthritis Res. Ther. (IF 4.4) Pub Date : 2024-12-02 Jinpeng Wei, Jian Li, Tianyang Li, Tao Xu, Yingchi Zhang, Shuhan Yang, Hua Wu, Haihu Hao
This study investigates the causal role of metabolites mediating immune cells in rheumatoid arthritis (RA) and ankylosing spondylitis (AS) through a Mendelian randomization (MR) study. The two-sample and two-step MR methods were used for the current analysis: (1) causal effects of immune cells on RA and AS; (2) mediation effects of metabolites. Inverse variance weighted (IVW) is the main method to
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Correction: Longitudinal assessment of reactivity and affinity profile of anti-Jo1 autoantibodies to distinct HisRS domains and a splice variant in a cohort of patients with myositis and anti-synthetase syndrome Arthritis Res. Ther. (IF 4.4) Pub Date : 2024-12-02 Antonella Notarnicola, Charlotta Preger, Susanna L. Lundström, Nuria Renard, Edvard Wigren, Eveline Van Gompel, Angeles S. Galindo-Feria, Helena Persson, Maryam Fathi, Johan Grunewald, Per-Johan Jakobsson, Susanne Gräslund, Ingrid E. Lundberg, Cátia Fernandes-Cerqueira
Correction: Arthritis Res Ther 24, 62 (2022) https://doi.org/10.1186/s13075-022-02745-6 Following publication of the original article [1], we have recently received a comment by PubPeer that has found a mistake in our Figure 1 D. The western blot image uploaded for patient P16 was by mistake the same as for patient P15. It was only when putting together the image that the error occurred and all calculations
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Gout-associated SNP at the IL1RN-IL1F10 region is associated with altered cytokine production in PBMCs of patients with gout and controls Arthritis Res. Ther. (IF 4.4) Pub Date : 2024-11-20 Orsolya I. Gaal, Megan Leask, Valentin Nica, Georgiana Cabău, Medeea Badii, Ioana Hotea, Dennis M de Graaf, Zhenhua Zhang, Yang Li, Cristina Pamfil, Simona Rednic, Tony R. Merriman, Tania O. Crișan, Leo A.B. Joosten
Gout is caused by the response of the innate immune system to monosodium urate (MSU) crystals. A recent gout GWAS identified a signal of genetic association at a locus encompassing IL1RN-IL1F10. Colocalisation analysis using Genotype Tissue Expression Database (GTEx) eQTL data showed that the signal overlaps with genetic control of IL1RN/IL1F10 gene expression. We assess the functional implications